38,560 results match your criteria Trematode Infection

A case of cerebral paragonimiasis misdiagnosed as eosinophilic granulomatosis with polyangiitis.

Neuropathology 2022 Jun 20. Epub 2022 Jun 20.

Department of Neurorogical Surgery, Nihon University School of Medicine, Tokyo, Japan.

Paragonimiasis is a parasitic disease caused by Paragonimus westermani infection, and migration to the brain results in cerebral paragonimiasis. Cerebral paragonimiasis is now extremely rare, but a few cases are still reported. A 48-year-old Japanese woman presented with right-hand convulsion, right-hand numbness, sputum, and fatigue. Read More

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Opisthorchis felineus infection is a risk factor for cholangiocarcinoma in Western Siberia: a hospital-based case-control study.

Clin Infect Dis 2022 Jun 20. Epub 2022 Jun 20.

Swiss Tropical and Public Health Institute, Allschwil, Switzerland.

Background: Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus (O. felineus), a bile duct dwelling trematode liver fluke is highly endemic. Read More

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Pneumatosis cystoides intestinalis accompanied by schistosomiasis: a case report.

J Int Med Res 2022 Jun;50(6):3000605221105160

Department of Pathology, Minhang Hospital, Fudan University, Shanghai, P. R. China.

Pneumatosis cystoides intestinalis (PCI) is a rare disease that most frequently occurs in the large and small intestine and has no obvious clinical symptoms. The main pathological feature is the presence of air-filled cysts in the intestinal submucosa, intermuscular wall, and subserous membrane. Conservative treatment is the first choice when no serious complications are present, whereas timely surgical treatment is needed for serious and life-threatening complications. Read More

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Molecular evidence on the presence of Schistosoma japonicum infection in snails along the Yangtze River, 2015-2019.

Infect Dis Poverty 2022 Jun 18;11(1):70. Epub 2022 Jun 18.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai, 200025, People's Republic of China.

Background: Due to sustained control activities, the prevalence of Schistosoma japonicum infection in humans, livestock and snails has decreased significantly in P. R. China, and the target has shifted from control to elimination according to the Outline of Healthy China 2030 Plan. Read More

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Multi-stage transcriptome profiling of the neglected food-borne echinostome Artyfechinostomum sufrartyfex reveal potential diagnostic and drug targets.

Acta Trop 2022 Jun 15;233:106564. Epub 2022 Jun 15.

Department of Zoology, School of Life sciences, Sikkim University, Gangtok, Sikkim, India. Electronic address:

Lack of effective surveillance and control methods for neglected helminth diseases particularly in context of rural areas in India is a serious concern in terms of public health. With regard to the emerging food-borne echinostomid Artyfechinostomum sufrartyfex infection in the country, the current study is an in silico attempt to screen for plausible diagnostic and drug targets against the trematode. Transcriptome of adult, encysted and excysted metacercaria stages of the parasite was generated using Illumina sequencing platform. Read More

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Bovine schistosomiasis in some selected areas of South Wollo and Oromia Zones of Amhara Region, North-East Ethiopia.

PLoS One 2022 17;17(6):e0259787. Epub 2022 Jun 17.

School of Veterinary Medicine, Wollo University, Dessie, Ethiopia.

A cross-sectional coprological and pathological study was conducted in five districts of South Wollo and Oromia Administrative Zones, Amhara regional state, Ethiopia from November 2020 to June 2021 to determine the prevalence and associated risk factors of Bovine Schistosomiasis and to characterize pathological lesions induced by the adult worm of Schistosoma bovis. For coprological examination, a total of 768 fecal samples were collected both from the field (384) and the abattoirs (384). An abattoir survey was carried out on 384 cattle to evaluate the performance of the sedimentation method. Read More

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Plant-derived compounds for the treatment of schistosomiasis: Improving efficacy via nano-drug delivery.

Niger J Clin Pract 2022 Jun;25(6):747-764

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

Schistosomiasis is a neglected infectious tropical disease that is second in occurrence only to hookworm infection in sub-Saharan Africa. Presently, chemotherapy is the main method of control and treatment of this disease due to the absence of a vaccine. However, Praziquantel, which is the only chemotherapeutic option, lacks efficacy against the early developmental stages of schistosomes. Read More

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Dynamic transcriptome landscape of pulmonary tissues of rats infected with .

Am J Transl Res 2022 15;14(5):3395-3406. Epub 2022 May 15.

School of Basic Medicine, Kunming Medical University Kunming 650504, Yunnan, China.

Paragonimiasis (pulmonary fluke disease) is a foodborne parasitic disease caused by trematode infections. is a characteristic species that was first identified in Yunnan Province of China. No direct evidence has yet proven that can infect humans. Read More

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The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models.

Front Public Health 2022 27;10:848633. Epub 2022 May 27.

Laboratory of Innovations in Therapies, Teaching and Bioproducts, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (LITEB/IOC/FIOCRUZ), Rio de Janeiro, Brazil.

Schistosomiasis is a widely distributed parasitic disease and one of the most important neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available treatment. In this context, tests with new PZQ formulations become relevant for disease control. This study evaluated the effects of PZQ treatment in the prepatent phase of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active pharmaceutical ingredient (PZQ-API). Read More

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High schistosomiasis-related mortality in Northeast Brazil: trends and spatial patterns.

Rev Soc Bras Med Trop 2022 6;55:e0431. Epub 2022 Jun 6.

Universidade Federal do Ceará, Faculdade de Medicina, Pós-Graduação em Saúde Pública, Fortaleza, CE, Brasil.

Background: We analyzed the trends and spatial patterns of schistosomiasis-related mortality in Northeast Brazil in 2000-2019.

Methods: A mixed population-based ecological study was conducted, using information on the underlying or associated causes of death. We used Joinpoint regression analysis to calculate the trends. Read More

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Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol.

BMC Infect Dis 2022 Jun 7;22(1):528. Epub 2022 Jun 7.

Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia, MR-6 Rm 2207, 345 Crispell Dr, Charlottesville, VA, 22908, USA.

Background: Deworming programs aimed at reducing morbidity and mortality from geohelminth infections are common in many countries where these infections are endemic, but data demonstrating increasing levels of resistance to albendazole and mebendazole are causes for concern. Studies to evaluate the clinical efficacy of deworming programs are critical to maintain high infection control goals.

Methods: We propose to assess the clinical efficacy of Peruvian national guidelines for deworming programs in a prospective observational study conducted in the Amazon River basin area near Iquitos, Peru. Read More

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Serological evaluation of the schistosome's secretory enzyme phytochelatin synthase and phosphoglycerate mutase for the detection of human Schistosoma japonicum infection.

Parasitol Res 2022 Jun 8. Epub 2022 Jun 8.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

Secretory enzymes from Schistosoma japonicum are promising candidate antigens in the diagnosis of schistosomiasis. Our previous studies have proven that thioredoxin peroxidase-1 (SjTPx-1) is useful for the detection of this parasitic disease in humans, water buffaloes, and dogs. In this study, we evaluated two more secretory enzymes namely phosphoglycerate mutase (SjPGM) and phytochelatin synthase (SjPCS) with SjTPx-1 as the reference antigen. Read More

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Bithyniid snails as hosts of Opisthorchiidae and Notocotylidae in the south of Western Siberia, Russia.

E A Serbina

Parasitol Res 2022 Jun 8. Epub 2022 Jun 8.

Institute of Systematics and Ecology of Animals Siberian Branch, Russian Academy of Sciences, Frunze, St. 11, Novosibirsk, 630091, Russia.

Opisthorchiasis and related infections are persistent and substantial public health burdens from eastern Europe to southeastern and northern Asia. Snails of the family Bithyniidae act as first intermediate hosts not only for the trematodes of the family Opisthorchiidae but also for those of the family Notocotylidae. There are certain morphological similarities between the aforementioned trematode cercariae. Read More

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Immunodiagnosis of cystic echinococcosis in livestock: Development and validation dataset of an ELISA test using a recombinant B8/2 subunit of .

Data Brief 2022 Jun 11;42:108255. Epub 2022 May 11.

London Centre for Neglected Tropical Disease Research and MRC Centre for Global Infectious Disease Analysis, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.

The accuracy of screening tests for detecting cystic echinococcosis (CE) in livestock depends on characteristics of the host-parasite interaction and the extent of serological cross-reactivity with other taeniid species. The AgB8 kDa protein is considered to be the most specific native or recombinant antigen for immunodiagnosis of ovine CE. A particular DNA fragment coding for rAgB8/2 was identified, that provides evidence of specific reaction in the serodiagnosis of metacestode infection. Read More

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Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice.

PLoS Pathog 2022 06 6;18(6):e1010596. Epub 2022 Jun 6.

Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.

Schistosomiasis is caused by parasitic flatworms known as schistosomes and affects over 200 million people worldwide. Prevention of T cell exhaustion by blockade of PD-1 results in clinical benefits to cancer patients and clearance of viral infections, however it remains largely unknown whether loss of PD-1 could prevent or cure schistosomiasis in susceptible mice. In this study, we found that S. Read More

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Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole.

Exp Parasitol 2022 Jul 30;238:108285. Epub 2022 May 30.

Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. Electronic address:

Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. Read More

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n. sp. (Digenea: Haploporidae) from the killifish (Cyprinodontiformes: Poeciliidae) from Argentina, morphological and molecular description.

J Helminthol 2022 May 31;96:e37. Epub 2022 May 31.

Aquatic Parasitology Laboratory, School of Fisheries, Aquaculture, and Aquatic Sciences, College of Agriculture, Auburn University, Auburn, Alabama, USA.

This paper presents a new haploporid digenean that expands the number of species of Saccoccoelioides to 27. The new species, Saccocoelioides kirchneri n. sp. Read More

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Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.

J Enzyme Inhib Med Chem 2022 Dec;37(1):1479-1494

NEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Florence, Italy.

The almost empty armamentarium to treat schistosomiasis, a neglected parasitic disorder caused by trematode flatworms of the genus , except Praziquantel (PZQ), urged to find new alternatives to fight this infection. Carbonic Anhydrase from (SmCA) is a possible new target against this nematode. Here, we propose new PZQ derivatives bearing a primary sulphonamide group in order to obtain hybrid drugs. Read More

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December 2022

Performance of a rapid immuno-chromatographic test (Schistosoma ICT IgG-IgM) for detecting Schistosoma-specific antibodies in sera of endemic and non-endemic populations.

PLoS Negl Trop Dis 2022 05 27;16(5):e0010463. Epub 2022 May 27.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Schistosomiasis, an acute and chronic parasitic disease caused by human pathogenic Schistosoma species, is a neglected tropical disease affecting more than 220 million people worldwide. For diagnosis of schistosomiasis, stool and urine microscopy for egg detection is still the recommended method, however sensitivity of these methods is limited. Therefore, other methods like molecular detection of DNA in stool, detection of circulating cathodic antigen in urine or circulating anodic antigen in urine and serum, as well as serological tests have gained more attention. Read More

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A new ferritin SjFer0 affecting the growth and development of Schistosoma japonicum.

Parasit Vectors 2022 May 24;15(1):177. Epub 2022 May 24.

State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, 2005 Song Hu Road, Shanghai, 200438, People's Republic of China.

Background: Schistosomiasis, an acute and chronic parasitic disease, causes substantial morbidity and mortality in tropical and subtropical regions of the world. Iron is an essential constituent of numerous macromolecules involving in important cellular reactions in virtually all organisms. Trematodes of the genus Schistosoma live in iron-rich blood, feed on red blood cells and store abundant iron in vitelline cells. Read More

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Human tumor necrosis factor alpha affects the egg-laying dynamics and glucose metabolism of Schistosoma mansoni adult worms in vitro.

Parasit Vectors 2022 May 24;15(1):176. Epub 2022 May 24.

Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Several studies have described the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni. hTNF-α affects the worm's development, metabolism, egg-laying, gene expression and protein phosphorylation. The available data on the influence of hTNF-α on egg-laying in S. Read More

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Fasciolopsis buski Detected in Humans in Bihar and Pigs in Assam, India.

Emerg Infect Dis 2022 06;28(6):1265-1268

The foodborne intestinal trematode Fasciolopsis buski causes the neglected zoonotic disease fasciolopsiasis. We detected F. buski infection in 14 pediatric patients in Sitamarhi, Bihar, and in pigs in Sivasagar, Assam, India. Read More

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Cost-effectiveness evaluation of different control strategies for Clonorchis sinensis infection in a high endemic area of China: A modelling study.

PLoS Negl Trop Dis 2022 05 23;16(5):e0010429. Epub 2022 May 23.

Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China.

Clonorchiasis is an important food-borne parasitic disease caused by Clonorchis sinensis infection. The evaluation of long-term cost-effectiveness of control strategies is important for disease control and prevention. The present study aimed to assess the cost-effectiveness of the three recommended strategies (i. Read More

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Potential Utility of Systemic Plasma Biomarkers for Evaluation of Pediatric Schistosomiasis in Western Kenya.

Front Immunol 2022 6;13:887213. Epub 2022 May 6.

Global Development, Elegance Biotechnologies, Wayne, PA, United States.

Introduction: Current diagnostic tools for schistosomiasis are limited, and new tests are necessary to enhance disease diagnosis and surveillance. Identification of novel disease-specific biomarkers may facilitate the development of such tests. We evaluated a panel of biomarkers used in sepsis and parasitic diseases for their potential suitability in the diagnosis of schistosomiasis. Read More

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Trematode Infection in a Freshwater Snail (Gastropoda: Bithyniidae) in Thailand.

Helminthologia 2022 Mar 4;59(1):111-116. Epub 2022 May 4.

Walai Rukhavej Botanical Research Institute, Mahasarakham University, Maha Sarakham 44150, Thailand.

1,024 individuals of were collected from 12 different localities in eight provinces from north, west, and central regions of Thailand. The infection of parasitic trematodes was investigated using shedding and crushing methods to search for cercariae and metacercariae. Trematode infection was found at a relatively low prevalence of 5. Read More

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The prophylactic and anti-fibrotic activity of phthalimido-thiazole derivatives in schistosomiasis mansoni.

Parasitol Res 2022 Jul 23;121(7):2111-2120. Epub 2022 May 23.

Department of Pharmaceutical Sciences, Federal University of Pernambuco (UFPE), S/N, Recife, PE, CEP 50740-525, Brazil.

Schistosomiasis mansoni is considered a serious public health problem. As praziquantel is the only drug recommended by the World Health Organization for the treatment and control of schistosomiasis, the development of new drugs is of great significance. In this work, we present the antischistosomal activity of a small set of phthalimido-thiazole derivatives against Schistosoma mansoni. Read More

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Implication of serum Nitric oxide and IgE in urinary schistosomiasis: The case of Bamendjing, Cameroon.

Acta Trop 2022 Aug 19;232:106504. Epub 2022 May 19.

Department of Biological Sciences, Faculty of Science, University of Bamenda, P.O Box 39 Bambili, Bamenda, North west, Cameroon. Electronic address:

Background: Urinary schistosomiasis (US), also known as bilharziasis is a waterborne parasitic infection most common in rural areas of developing countries. The infection is associated with haematuria but little or nothing is known about its association with other urinary parameters, induction of Nitric Oxide (NO) and IgE production around the Bamendjing Dam an area highly suspected of Schistosoma haematobium infections. The study sought to address this problem for possible future interventions and control. Read More

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Behavioral effects and inflammatory markers in the brain and periphery after repeated social defeat stress burdened by Opisthorchis felineus infection in mice.

Physiol Behav 2022 08 17;252:113846. Epub 2022 May 17.

Department of Medicinal Chemistry, Laboratory of Pharmacological Research, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, Novosibirsk, Russia.

The combination of 4-week repeated social defeat stress (RSDS) and Opisthorchis felineus infection was modeled in C57BL/6 mice. Various parameters were compared between three experimental groups of male mice (SS: mice subjected to RSDS, OF: mice infected with O. felineus, and OF + SS: mice subjected to both adverse factors) and behavior-tested and intact (INT) controls. Read More

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The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game.

Front Immunol 2022 3;13:846108. Epub 2022 May 3.

Department of Tropical and Infectious Diseases, Institute of Primate Research, Nairobi, Kenya.

The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of schistosomiasis as a public health problem. To date, control strategies have focused on effective diagnostics, mass drug administration, complementary and integrative public health interventions. Non-mammalian intermediate hosts and other vertebrates promote transmission of schistosomiasis and have been utilized as experimental model systems. Read More

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