35,422 results match your criteria Trematode Infection


Progenesis and facultative life cycle abbreviation in trematode parasites: are there more constraints than costs?

Int J Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, University of Alberta, Edmonton T6G 2E9, Alberta, Canada. Electronic address:

Complex life cycles provide advantages to parasites (longer life span, higher fecundity, etc.), but also represent a series of unlikely events for which many adaptations have evolved (asexual multiplication, host finding mechanisms, etc.). Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.11.009DOI Listing
February 2019
1 Read

Fresh water snails as intermediate host of trematodes in Iran: A systematic.

Epidemiol Health 2019 Jan 7:e2019001. Epub 2019 Jan 7.

Associate Professor, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari,, Sari, Iran.

Objectives: Freshwater snails, as first intermediate hosts of trematodes, can cause health hazards in animals and humans. Recently, WHO has included Iran among six countries known to have a serious problem with fascioliasis. In addition, Cercarial dermatitis is a job-related disease that is seen often in paddy workers and swimmers of Iran particularly in the Mazandaran province. Read More

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http://dx.doi.org/10.4178/epih.e2019001DOI Listing
January 2019
1 Read

Results of a national school-based deworming programme on soil-transmitted helminths infections and schistosomiasis in Kenya: 2012-2017.

Parasit Vectors 2019 Feb 7;12(1):76. Epub 2019 Feb 7.

Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

Background: Soil-transmitted helminth (STH) and schistosome infections are among the most prevalent neglected tropical diseases (NTDs) in the world. School-aged children are particularly vulnerable to these chronic infections that can impair growth, nutritional status and cognitive ability. Mass drug administration (MDA) delivered either once or twice annually is a safe and effective approach recommended by the World Health Organization (WHO) to reduce worm burden. Read More

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http://dx.doi.org/10.1186/s13071-019-3322-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367841PMC
February 2019

Pooled population pharmacokinetic analysis of tribendimidine for the treatment of infections.

Antimicrob Agents Chemother 2019 Feb 4. Epub 2019 Feb 4.

Swiss Tropical & Public Health Institute, Basel, Switzerland

Opisthorchiasis, caused by the food-borne trematode , affects more than 8 million people in Southeast Asia. In the framework of a phase 2b clinical trial conducted in Lao PDR, pharmacokinetic samples from 125 adult and adolescent patients treated with 400 mg tribendimidine were obtained following the design of an sparse sampling scheme at 20 min, 2, 7.75, 8 and 30 h after treatment, using dried blood spot sampling. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01391-18
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http://dx.doi.org/10.1128/AAC.01391-18DOI Listing
February 2019
2 Reads

Effectiveness of as a controller of in experimental infections of .

Trop Parasitol 2018 Jul-Dec;8(2):88-93. Epub 2018 Dec 27.

Regional Parasitology Research Center Inka (CIPRI), Cusco, Peru.

Background: is an annelid symbiotically associated with lymnaeid snails as . This association is considered a preventive mechanism against trematode miracidia infection, including . The objective of this study was to determine the effectiveness of as a natural controller of in laboratory conditions. Read More

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http://dx.doi.org/10.4103/tp.TP_24_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329262PMC
December 2018
1 Read

Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23.

Parasit Vectors 2019 Jan 28;12(1):63. Epub 2019 Jan 28.

Janssen Diagnostics, Janssen R&D, Turnhoutseweg 30, 2340, Beerse, Belgium.

Background: Ov16 serology is considered a reference method for Onchocerca volvulus epidemiological mapping. Given the suboptimal sensitivity of this test and the fact that seroconversion takes more than a year after infection, additional serological tests might be needed to guide onchocerciasis elimination programmes. Recently, two linear epitopes encoded in OvMP-1 and OvMP-23 peptides were introduced as serological markers, but the observed antibody cross-reactivity in samples originating from Onchocerca volvulus non-endemic areas required further investigation. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350367PMC
January 2019
8 Reads

Population genetic structure of Schistosoma bovis in Cameroon.

Parasit Vectors 2019 Jan 24;12(1):56. Epub 2019 Jan 24.

Université de Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Université de Montpellier, F-66860, Perpignan, France.

Background: Schistosomiasis is neglected tropical parasitic disease affecting both humans and animals. Due to the human health impact, population genetic studies have focused on the three main human-infecting schistosome species: Schistosoma mansoni, S. haematobium and S. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3307-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346511PMC
January 2019
4 Reads

Immunological Parameters of the Pomacea lineata Spix, 1827 (Mollusca: Caenogastropoda) Exposed to Schistosoma mansoni Sambon, 1907.

Acta Parasitol 2019 Jan 22. Epub 2019 Jan 22.

Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, UFRPE-DMFA, Av. Dom Manoel de Medeiros s/n Dois, s/n, Dois Irmãos District, Recife, PE, 52171-900, Brazil.

Introduction: Pomacea lineata acts as the natural biological controller of Biomphalaria glabrata, the intermediate host of Schistosoma mansoni, as they are found in the same environment. However, there are no studies reporting an infection in P. lineata due to S. Read More

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http://dx.doi.org/10.2478/s11686-018-00005-9DOI Listing
January 2019

A Biomphalaria glabrata peptide that stimulates significant behaviour modifications in aquatic free-living Schistosoma mansoni miracidia.

PLoS Negl Trop Dis 2019 01 22;13(1):e0006948. Epub 2019 Jan 22.

School of Science and Education, Genecology Research Centre, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia.

The human disease schistosomiasis (or bilharzia) is caused by the helminth blood fluke parasite Schistosoma mansoni, which requires an intermediate host, the freshwater gastropod snail Biomphalaria glabrata (the most common intermediate host). The free-swimming parasite miracidia utilise an excellent chemosensory sense to detect and locate an appropriate host. This study investigated the biomolecules released by the snail that stimulate changes in the behaviour of the aquatic S. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006948DOI Listing
January 2019
1 Read

Prevalence of bovine fascioliasis and economic impact associated with liver condemnation in abattoirs in Mongu district of Zambia.

BMC Vet Res 2019 Jan 21;15(1):33. Epub 2019 Jan 21.

Department of Veterinary Services, Mulungushi House, Lusaka, Zambia.

Background: Fascioliasis is a trematode zoonotic snail-borne disease of public health and economic importance. The disease causes liver damage and is hardly recognized by medical personnel hence, is rarely considered as the differential diagnosis. In animals, the disease leads to mortalities, growth retardation, drop in livestock production and condemnation of the infected livers during meat inspection. Read More

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http://dx.doi.org/10.1186/s12917-019-1777-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341647PMC
January 2019
7 Reads

Transcriptomic analysis of reduced sensitivity to praziquantel in Schistosoma mansoni.

Mol Biochem Parasitol 2019 Mar 15;228:6-15. Epub 2019 Jan 15.

Dept. of Biology, University of New Mexico, Albuquerque, NM, USA. Electronic address:

Schistosomiasis is an intravascular parasitic infection estimated to affect over 206 million people, the majority of whom live in Africa where the trematode worms Schistosoma mansoni and Schistosoma haematobium are the major causative agents. While a number of drugs have been used to treat schistosomiasis, praziquantel (PZQ) is the only one that is widely available, relatively cheap, and easy to use. The reliance on a single drug for the treatment of such a prevalent disease is a cause for concern due to the potential for resistance to render PZQ ineffective. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01666851183020
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http://dx.doi.org/10.1016/j.molbiopara.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372308PMC
March 2019
3 Reads

The cost of a disease targeted for elimination in Brazil: the case of schistosomiasis mansoni.

Mem Inst Oswaldo Cruz 2019 Jan 14;114:e180347. Epub 2019 Jan 14.

Universidade de Brasília, Núcleo de Medicina Tropical, Brasília, DF, Brasil.

Background: Schistosomiasis mansoni is a poverty-related parasitic infection that has a variety of clinical manifestations. We consider the disability and deaths caused by schistosomiasis unacceptable for a tool-ready disease. Its condition in Brazil warrants an analysis that will enable better understanding of the local health losses and contribute to the complex decision-making process. Read More

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http://dx.doi.org/10.1590/0074-02760180347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340134PMC
January 2019
1 Read

A new genus and species of the Dasybatotreminae Bychowsky, 1957 (Monogenea: Monocotylidae), parasitic on Hypanus dipterurus (Jordan Gilbert) (Myliobatiformes: Dasyatidae) in the Southeastern Pacific Ocean off Peru.

Zootaxa 2018 Dec 6;4527(3):347-356. Epub 2018 Dec 6.

Programa de Pós-Graduação em Biologia Animal da Universidade Federal Rural do Rio de Janeiro, BR 465, Km 7, CEP 23890-000, Seropédica, Rio de Janeiro, Brazil. Laboratorio de Parasitología General y Especializada, Facultad de Ciencias Naturales y Matemática, Universidad Nacional Federico Villarreal (UNFV), Código postal 15007, El Agustino, Lima, Perú..

Peruanocotyle n. gen. is proposed to accommodate Peruanocotyle chisholmae n. Read More

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http://dx.doi.org/10.11646/zootaxa.4527.3.4DOI Listing
December 2018
1 Read

Fasciola gigantica: Comparison of the tegumental ultrastructure in newly excysted metacercariae and in vitro penetrated juvenile flukes indicates intracellular sources of molecules with vaccinal and immunomodulatory potential.

Vet Parasitol 2019 Jan 7;265:38-47. Epub 2018 Dec 7.

School of Biological Sciences, The Queen's University of Belfast, Belfast, BT9 7BL, United Kingdom.

Using in vitro procedures to prepare newly excysted metacercariae and gut-penetrated juvenile Fasciola gigantica, the ultrastructural features of the tegumental syncytium and perikarya of these ephemeral stages in the host-invasion process were compared. The T0-type tegumental cells in newly excysted metacercariae are packed with stored T0 granules which, following transport to the surface membrane of the syncytium, discharge by exocytosis to maintain the glycocalyx. The T0 cells become depleted of T0 granules during the penetration process, shrink in size, and initiate autophagy in the cytoplasm to facilitate metamorphosis from a storage function to active biosynthesis. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.019DOI Listing
January 2019
3 Reads

NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB.

Parasit Vectors 2019 Jan 11;12(1):29. Epub 2019 Jan 11.

Department of Parasitology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, Hubei, People's Republic of China.

Background: NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inflammasome inhibitor, MCC950, to investigate whether it inhibited liver fibrosis, and explored the preliminary molecular mechanism.

Methods: BALB/c mice were infected with 15 cercariae through the abdominal skin. Read More

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http://dx.doi.org/10.1186/s13071-018-3223-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330481PMC
January 2019
2 Reads

A study of tribendimidine effects in vitro and in vivo on the liver fluke Opisthorchis felineus.

Parasit Vectors 2019 Jan 11;12(1):23. Epub 2019 Jan 11.

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (SB RAS), 10 Lavrentiev Ave, Novosibirsk, 630090, Russia.

Background: The food-borne liver fluke Opisthorchis felineus is an epidemiologically important species and the causative agent of opisthorchiasis across an extensive territory of Eurasia. For decades, treatment of opisthorchiasis has been based on praziquantel. Tribendimidine could be an alternative drug that has been successfully tested for Opisthorchis viverrini and Clonorchis sinensis infections. Read More

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http://dx.doi.org/10.1186/s13071-019-3288-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329057PMC
January 2019
1 Read

Infection Status of Isthmiophora hortensis Metacercariae in Dark Sleepers, Odontobutis Species, from Some Water Systems of the Republic of Korea.

Korean J Parasitol 2018 Dec 31;56(6):633-637. Epub 2018 Dec 31.

Division of Vectors and Parasitic Diseases, Centers for Disease Control and Prevention, Osong 28159, Korea.

Present study was performed to survey on infection status of Isthmiophora hortensis (formerly Echinostoma hortense) metacercariae (IhMc) in dark sleepers, Odontobutis spp., from some water systems of the Republic of Korea. A total of 237 Odontobutis spp. Read More

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http://dx.doi.org/10.3347/kjp.2018.56.6.633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327203PMC
December 2018
1 Read

Impact of Single Dose Praziquantel Treatment on Schistosoma haematobium Infection among School Children in an Endemic Nigerian Community.

Korean J Parasitol 2018 Dec 31;56(6):577-581. Epub 2018 Dec 31.

Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Kaduna State, Nigeria.

Schistosomiasis is prevalent in Nigeria, and the foremost pathogen is Schistosoma haematobium, which affects about 29 million people. Single dose of the drug praziquantel is often recommended for treatment but the efficacy has not been documented in certain regions. Therefore, this study was designed to assess the impact of single dose praziquantel treatment on S. Read More

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http://dx.doi.org/10.3347/kjp.2018.56.6.577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327198PMC
December 2018
2 Reads

Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.

PLoS Negl Trop Dis 2019 01 10;13(1):e0007086. Epub 2019 Jan 10.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Introduction: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343929PMC
January 2019
5 Reads

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly.

Acta Cir Bras 2018 Dec;33(12):1103-1109

PhD, Associate Professor, Department of Surgery, School of Medicine, UFMG, Belo Horizonte-MG, Brazil. Scientific, intellectual, conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis; manuscript preparation and writing; critical revision.

Purpose: To evaluate a possible relationship between the size of the spleen and values of circulating blood elements in patients with schistosomatic splenomegaly.

Methods: ixty one patients with hepatosplenic schistosomiasis mansoni underwent a clinical exam and peripheral venous blood was collected for a hemogram. The erythrocyte, hemoglobin, hematocrit, leukocyte, and platelet values were determined. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000008DOI Listing
December 2018
3 Reads

The anthelmintic drug praziquantel promotes human Tr1 differentiation.

Immunol Cell Biol 2019 Jan 8. Epub 2019 Jan 8.

The MRC Centre for Inflammation Research, Edinburgh Centre for MS research, University of Edinburgh, Edinburgh, UK.

Praziquantel (PZQ) is an anthelminthic human and veterinary drug used to treat trematode and cestode worms. Changes in immune responses have been demonstrated in humans following curative PZQ treatment of schistosome infections. These changes have been attributed to the removal of immunosupressive worms and immune responses to parasite antigens exposed from dying worms. Read More

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http://doi.wiley.com/10.1111/imcb.12229
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http://dx.doi.org/10.1111/imcb.12229DOI Listing
January 2019
2 Reads

Clonorchiasis sinensis detected by laparoscopic exploration of biliary tracts in two patients with obstructive jaundice.

BMC Infect Dis 2019 Jan 8;19(1):33. Epub 2019 Jan 8.

Department of Hepatobiliary, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.

Background: Hepatic clonorchiasis is one of the most prevalent food-borne parasitic diseases worldwide. Clonorchis sinensis, the pathogen, is the major parasitic trigger contributing to cholangitis, cholelithiasis, and even cholangiocarcinoma. Unfortunately, unspecific clinical manifestations of patients with hepatic clonorchiasis tend to mislead clinicians to neglect or misdiagnose them, following ignorance of appropriate therapy. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3679-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325787PMC
January 2019
9 Reads

Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Infection.

Front Immunol 2018 20;9:3019. Epub 2018 Dec 20.

Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Eosinophils have been long associated with helminthic infections, although their functions in these diseases remain unclear. During schistosomiasis caused by the trematode , eosinophils are specifically recruited and migrate to sites of granulomatous responses where they degranulate. However, little is known about the mechanisms of eosinophil secretion during this disease. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306457PMC
December 2018
2 Reads

Systemic Cytokine and Chemokine Profiles in Individuals With Infection and Low Parasite Burden.

Front Immunol 2018 18;9:2975. Epub 2018 Dec 18.

Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.

Intestinal schistosomiasis, caused by the parasitic trematode , is a chronic disease and the prolonged and continuous exposure to antigens results in a deviation of the host's immune response. For diagnosis, the Kato-Katz (KK) method is recommended, however, this method showed low accuracy in areas of low endemicity. This study aimed to characterize the cytokine and chemokine profile of individuals with an extremely low parasite load (<4 eggs per gram of feces), e. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305627PMC
December 2018
1 Read

Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship.

J Vector Borne Dis 2018 Jul-Sep;55(3):245

Visiting Professor, Hainan Medical University, China.

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http://dx.doi.org/10.4103/0972-9062.249485DOI Listing
February 2019
1 Read

Spatial risk analysis on occurrences and dispersal of in and endemic area for schistosomiasis.

J Vector Borne Dis 2018 Jul-Sep;55(3):208-214

Laboratory and Reference Service in Schistosomiasis, Department of Parasitology, Aggeu Magalhães Institute, Fiocruz-Ministry of Health, Recife, Pernambuco, Brazil.

Background & Objectives: : Schistosomiasis is a rural endemic disease that has been expanding to urban and coastal areas in the state of Pernambuco, Brazil. The aim of this study was to characterize the distribution of breeding sites of the causative vector, Biomphalaria straminea in an endemic municipality for schistosomiasis and to present the predictive models for occurrences and dispersal of this vector snail to new areas.

Methods: : A malacological survey was conducted during January to December 2015 in the municipality of São Lourenço da Mata, Pernambuco, Brazil to identify the breeding sites of Biomphalaria. Read More

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http://dx.doi.org/10.4103/0972-9062.249142DOI Listing
February 2019
2 Reads

Prevalence and risk factors of bovine schistosomiasis in Northwestern Ethiopia.

BMC Vet Res 2019 Jan 7;15(1):12. Epub 2019 Jan 7.

Department of Biology, Jigjiga University, P.O. Box- 1020, Jijiga, Ethiopia.

Background: Parasitic diseases remain major bottle neck to livestock development in developing nations. The objective of this study was to determine the prevalence and associated risk factors of Bovine Schistosomiasis (BS) in South Achefer District, northwestern Ethiopia.

Methods: A cross-sectional copro-parasitological and observational study was conducted in South Achefer district from October, 2015 to April, 2016. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1757-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322276PMC
January 2019
11 Reads

Evolution, phylogenetic distribution and functional ecology of division of labour in trematodes.

Parasit Vectors 2019 Jan 4;12(1). Epub 2019 Jan 4.

Department of Biological Sciences, University of Alberta, Edmonton, Canada.

Division of labour has evolved in many social animals where colonies consist of clones or close kin. It involves the performance of different tasks by morphologically distinct castes, leading to increased colony fitness. Recently, a form of division of labour has been discovered in trematodes: clonal rediae inside the snail intermediate host belong either to a large-bodied reproductive caste, or to a much smaller and morphologically distinct 'soldier' caste which defends the colony against co-infecting trematodes. Read More

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http://dx.doi.org/10.1186/s13071-018-3241-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320615PMC
January 2019
1 Read

Assessing the performance of a Fasciola gigantica serum antibody ELISA to estimate prevalence in cattle in Cameroon.

BMC Vet Res 2019 Jan 3;15(1). Epub 2019 Jan 3.

Veterinary Parasitology, Institute of Infection and Global Health, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool, L3 5RF, UK.

Background: Cattle rearing in Cameroon is both economically and culturally important, however parasitic diseases detrimentally impact cattle productivity. In sub-Saharan Africa bovine fasciolosis is generally attributed to F. gigantica, although understanding of Fasciola species present and local epidemiology in individual countries is patchy. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1762-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318879PMC
January 2019
5 Reads

Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice.

BMC Complement Altern Med 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

Background: Considerable morbidity, mortality, and economic loss result from schistosomiasis infection. Deposition of Schistosoma eggs in the hepatic portal vein is considered as the main causative agent for the development of liver fibrosis and subsequent liver cirrhosis. Probiotics are exogenous and beneficial microorganisms to living hosts against the harmful effect of many parasites. Read More

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http://dx.doi.org/10.1186/s12906-018-2406-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318950PMC
January 2019
3 Reads
2.020 Impact Factor

Patterns of Fasciola hepatica infection in Danish dairy cattle: implications for on-farm control of the parasite based on different diagnostic methods.

Parasit Vectors 2018 Dec 29;11(1):674. Epub 2018 Dec 29.

Research Group for Veterinary Parasitology, Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlægevej 100, DK-1871, Frederiksberg C, Denmark.

Background: Bovine fasciolosis is an economically important livestock disease in Europe, and represents a particular challenge for organic farms, where cattle are grazed extensively and the use of anthelmintic is limited. A two-year longitudinal study was conducted on two conventional and two organic Danish dairy farms to examine the current temporal trend of F. hepatica infection on-farm, and to gather data of practical relevance for parasite control. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-018-3248-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310998PMC
December 2018
4 Reads

Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study.

PLoS Negl Trop Dis 2018 12 27;12(12):e0007002. Epub 2018 Dec 27.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston MA, United States of America.

Background: Neglected tropical diseases (NTDs) account for a large disease burden in sub-Saharan Africa. While the general cost-effectiveness of NTD interventions to improve health outcomes has been assessed, few studies have also accounted for the financial and education gains of investing in NTD control.

Methods: We built on extended cost-effectiveness analysis (ECEA) methods to assess the health gains (e. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007002
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http://dx.doi.org/10.1371/journal.pntd.0007002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307713PMC
December 2018
11 Reads

Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis.

PLoS Negl Trop Dis 2018 12 27;12(12):e0007000. Epub 2018 Dec 27.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health, China; National Center for International Research on Tropical Diseases, China; WHO Collaborating Center for Tropical Diseases, Shanghai, China.

Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the functional polarization of macrophages and the associated underlying molecular mechanisms during the pathogenesis of schistosomiasis remains unknown. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307705PMC
December 2018
2 Reads

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production.

Parasit Vectors 2018 Dec 27;11(1):668. Epub 2018 Dec 27.

National Research Council, Institute of Cell Biology and Neurobiology, Campus A. Buzzati-Traverso, Monterotondo (Roma), Italy.

Background: Novel anti-schistosomal multi-stage drugs are needed because only a single drug, praziquantel, is available for the treatment of schistosomiasis and is poorly effective on larval and juvenile stages of the parasite. Schistosomes have a complex life-cycle and multiple developmental stages in the intermediate and definitive hosts. Acetylation and deacetylation of histones play pivotal roles in chromatin structure and in the regulation of transcription in eukaryotic cells. Read More

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http://dx.doi.org/10.1186/s13071-018-3268-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307185PMC
December 2018
2 Reads

Effects of Parasite Infection and Host Body Size on Habitat Associations of Invasive Aquatic Snails: Implications for Environmental Monitoring.

J Aquat Anim Health 2018 Dec 23. Epub 2018 Dec 23.

Department of Geography, King's College London, Strand, London, WC2R 2LS, UK.

The Comal River, a spring-fed system in central Texas, was invaded in the 1960s by two Asian aquatic snails (Thiaridae: red-rimmed melania Melanoides tuberculata and quilted melania Tarebia granifera) and subsequently by three of their trematode parasites (the avian eye-fluke Philophthalmus gralli in the 1960s; the gill trematode Centrocestus formosanus in the 1990s; and the intestinal fluke Haplorchis pumilio in the 2000s). Previous snail collections (2001-2002) established that habitat conditions significantly affect the distribution of both snail species. However, the effects of snail size (known to influence infection prevalence) and habitat conditions (known to influence snail size) on trematode infection patterns in this system were not evaluated. Read More

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http://dx.doi.org/10.1002/aah.10059DOI Listing
December 2018
1 Read

General contextual effects on neglected tropical disease risk in rural Kenya.

PLoS Negl Trop Dis 2018 12 21;12(12):e0007016. Epub 2018 Dec 21.

International Livestock Research Institute, Nairobi, Kenya.

The neglected tropical diseases (NTDs) are characterized by their tendency to cluster within groups of people, typically the poorest and most marginalized. Despite this, measures of clustering, such as within-group correlation or between-group heterogeneity, are rarely reported from community-based studies of NTD risk. We describe a general contextual analysis that uses multi-level models to partition and quantify variation in individual NTD risk at multiple grouping levels in rural Kenya. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007016
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http://dx.doi.org/10.1371/journal.pntd.0007016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342328PMC
December 2018
6 Reads

Translating preventive chemotherapy prevalence thresholds for Schistosoma mansoni from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test.

PLoS Negl Trop Dis 2018 12 14;12(12):e0006941. Epub 2018 Dec 14.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. The point-of-care circulating cathodic antigen (POC-CCA) is a promising rapid diagnostic test detecting antigen output of living worms in urine and results are reported as trace, 1+, 2+, and 3+. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006941
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http://dx.doi.org/10.1371/journal.pntd.0006941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310297PMC
December 2018
7 Reads

Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis.

Parasit Vectors 2018 Dec 14;11(1):640. Epub 2018 Dec 14.

Animal Health Department (Parasitology and Parasitic Diseases), Faculty of Veterinary Medicine, University of Córdoba, Campus de Rabanales, Ctra. Madrid-Cádiz, km 396, 14014, Córdoba, Spain.

Background: The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal cavity (PC) towards the liver. In this study, we aimed to determine the immunophenotypes of the PCP and to analyse the dynamics of the recruitment of the PCP during the early and late stage of the infection in sheep infected with F. hepatica. Read More

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http://dx.doi.org/10.1186/s13071-018-3250-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295066PMC
December 2018

Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.

BMC Infect Dis 2018 Dec 14;18(1):662. Epub 2018 Dec 14.

Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.

Background: Large scale administration of the anthelminthic drug praziquantel (PZQ) to at-risk populations is the cornerstone of schistosomiasis control, although persisting high prevalence of infections in some areas and growing concerns of PZQ resistance have revealed the limitations of this strategy. Most studies assessing PZQ efficacy have used relatively insensitive parasitological diagnostics, such as the Kato-Katz (KK) and urine-filtration methods, thereby overestimating cure rates (CRs). This study aims to determine the efficacy of repeated PZQ treatments against Schistosoma mansoni infection in school-aged children in Côte d'Ivoire using the traditional KK technique, as well as more sensitive antigen- and DNA-detection methods. Read More

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http://dx.doi.org/10.1186/s12879-018-3554-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295059PMC
December 2018

Schistosomiasis is associated with incident HIV transmission and death in Zambia.

PLoS Negl Trop Dis 2018 12 13;12(12):e0006902. Epub 2018 Dec 13.

Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.

Background: We examined relationships between schistosome infection, HIV transmission or acquisition, and all-cause death.

Methods: We retrospectively tested baseline sera from a heterosexual HIV-discordant couple cohort in Lusaka, Zambia with follow-up from 1994-2012 in a nested case-control design. Schistosome-specific antibody levels were measured by ELISA. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006902
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http://dx.doi.org/10.1371/journal.pntd.0006902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292564PMC
December 2018
9 Reads

Unresolved Splenomegaly in Recently Resettled Congolese Refugees - Multiple States, 2015-2018.

MMWR Morb Mortal Wkly Rep 2018 12 14;67(49):1358-1362. Epub 2018 Dec 14.

In 2014, panel physicians from the International Organization for Migration (IOM), who conduct Department of State-required predeparture examinations for U.S.-bound refugees at resettlement sites in Uganda, noticed an unusually high number of Congolese refugees with enlarged spleens, or splenomegaly. Read More

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http://dx.doi.org/10.155850/mmwr.mm6749a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300079PMC
December 2018
3 Reads

Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: A phase 3 randomized, controlled trial in Senegalese children.

PLoS Negl Trop Dis 2018 12 7;12(12):e0006968. Epub 2018 Dec 7.

Académie des Sciences, 23 Quai de Conti, Paris, France.

Background: Urinary schistosomiasis, the result of infection by Schistosoma haematobium (Sh), remains a major global health concern. A schistosome vaccine could represent a breakthrough in schistosomiasis control strategies, which are presently based on treatment with praziquantel (PZQ). We report the safety and efficacy of the vaccine candidate recombinant 28-kDa glutathione S-transferase of Sh (rSh28GST) designated as Bilhvax, in a phase 3 trial conducted in Senegal. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300301PMC
December 2018
2 Reads

Ultrastructure of mature spermatozoa of three Bucephalidae (Prosorhynchus longisaccatus, Rhipidocotyle khalili and Bucephalus margaritae) and phylogenetic implications.

Parasite 2018 7;25:65. Epub 2018 Dec 7.

UMR 6134 SPE, CNRS - Università di Corsica, Campus Grimaldi, 20250 Corte, Corsica, France.

We describe here the mature spermatozoa of three species of bucephalids, namely Bucephalus margaritae, Rhipidocotyle khalili and Prosorhynchus longisaccatus. This study provides the first ultrastructural data on the genera Bucephalus and Rhipidocotyle and enabled us to confirm the model of the mature spermatozoon in the Bucephalinae. The spermatozoon exhibits two axonemes with the 9 + "1" pattern of the Trepaxonemata, one of which is very short, lateral expansion, external ornamentation of the plasma membrane located in the anterior extremity of the spermatozoon and associated with cortical microtubules, spine-like bodies, a mitochondrion, and a nucleus. Read More

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http://dx.doi.org/10.1051/parasite/2018065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284405PMC
January 2019
1 Read

Six new dactylogyrid species (Platyhelminthes, Monogenea) from the gills of cichlids (Teleostei, Cichliformes) from the Lower Congo Basin.

Parasite 2018 7;25:64. Epub 2018 Dec 7.

Research Group Zoology: Biodiversity, & Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Belgium - Laboratory of Biodiversity and Evolutionary Genomics, University of Leuven, Charles Deberiotstraat 42, 3000 Leuven, Belgium - Department of Botany and Zoology, Faculty of Science, Masaryk University, Kamenice 735/5, 625 00 Brno, Czech Republic - Zoology Unit, Finnish Museum of Natural History, University of Helsinki, Pohjoinen Rautatiekatu 13, 00100 Helsinki, Finland.

The Lower Congo Basin is characterized by a mangrove-lined estuary at its mouth and, further upstream, by many hydrogeographical barriers such as rapids and narrow gorges. Five localities in the mangroves and four from (upstream) left bank tributaries or pools were sampled. On the gills of Coptodon tholloni, Coptodon rendalli, Hemichromis elongatus, Hemichromis stellifer and Tylochromis praecox, 17 species of parasites (Dactylogyridae & Gyrodactylidae, Monogenea) were found, eight of which are new to science. Read More

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http://dx.doi.org/10.1051/parasite/2018059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284406PMC
January 2019
2 Reads

Morphological and molecular characterization of invasive Biomphalaria straminea in southern China.

Infect Dis Poverty 2018 Dec 8;7(1):120. Epub 2018 Dec 8.

National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.

Background: Schistosomiasis is a common parasitic disease designated as a neglected tropical disease by the World Health Organization. Schistosomiasis mansoni is a form of the disease that is caused by the digenean trematode Schistosoma mansoni, transmitted through Biomphalaria spp. as an intermediate host. Read More

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http://dx.doi.org/10.1186/s40249-018-0505-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286595PMC
December 2018
1 Read

Whole-genome sequence of the oriental lung fluke Paragonimus westermani.

Gigascience 2019 01 1;8(1). Epub 2019 Jan 1.

The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, 37 Kent St, Translational Research Institute (TRI), Wooloongabba, QLD 4102.

Background: Foodborne infections caused by lung flukes of the genus Paragonimus are a significant and widespread public health problem in tropical areas. Approximately 50 Paragonimus species have been reported to infect animals and humans, but Paragonimus westermani is responsible for the bulk of human disease. Despite their medical and economic importance, no genome sequence for any Paragonimus species is available. Read More

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https://academic.oup.com/gigascience/advance-article/doi/10.
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http://dx.doi.org/10.1093/gigascience/giy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329441PMC
January 2019
10 Reads

TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.

Int J Parasitol Drugs Drug Resist 2018 12 20;8(3):571-586. Epub 2018 Nov 20.

Center for Discovery and Innovation in Parasitic Diseases, University of California, 1700 4th St, San Francisco, CA, 94158, USA; Department of Pathology, University of California, 1700 4th St, San Francisco, CA, 94158, USA. Electronic address:

Treatment of schistosomiasis relies precariously on just one drug, praziquantel (PZQ). In the search for alternatives, 15 S-[2-(alkylamino)alkane] thiosulfuric acids were obtained from a previous research program and profiled in mice for efficacy against both mature (>42-day-old) and juvenile (21-day-old) Schistosoma mansoni using a screening dose of 100 mg/kg PO QDx4. One compound, S-[2-(tert-butylamino)-1-phenylethane] thiosulfuric acid (TPT sulfonate), was the most effective by decreasing female and male worm burdens by ≥ 90% and ≥46% (mature), and ≥89% and ≥79% (juvenile), respectively. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287543PMC
December 2018
1 Read

Oxfendazole: a promising agent for the treatment and control of helminth infections in humans.

Expert Rev Anti Infect Ther 2019 Jan 10;17(1):51-56. Epub 2018 Dec 10.

e Department of International Health , Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.

Introduction: Oxfendazole (methyl [5-(phenylsulphinyl)-1H benzimidazole-2-yl] carbamate) has a particularly long metabolic half-life in ruminants, and its metabolite fenbendazole also has anthelminthic action. A very limited number of drugs are available for the treatment of some zoonotic helminth infections, such as neurocysticercosis and echinococcosis. More recent work has expanded oxfendazole's nonclinical safety profile and demonstrated its safety and bioavailability in healthy human volunteers, thus advancing the possibility of a new and greatly needed option for antiparasitic treatment of geohelminths and tissue parasites. Read More

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http://dx.doi.org/10.1080/14787210.2018.1555241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376865PMC
January 2019
2 Reads
3.461 Impact Factor

Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):795-801

Laboratório Avançado de Saúde Pública, Instituto Gonçalo Moniz, Salvador, BA, Brasil.

Introduction: Portal hypertension and periportal fibrosis commonly occur in severe Schistosoma mansoni infection. Changes in lipid profile and elevated levels of circulating liver enzymes have also been described in infected individuals. The present study sought to assess the alterations in laboratory parameters associated with liver disorder in individuals infected by S. Read More

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http://dx.doi.org/10.1590/0037-8682-0113-2018DOI Listing
February 2019
2 Reads

A survey of freshwater and terrestrial snails in a predominantly urban municipality of Rio de Janeiro State, Brazil, with emphasis on human parasites vectors.

Rev Inst Med Trop Sao Paulo 2018 Nov 29;60:e76. Epub 2018 Nov 29.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Rio de Janeiro, Rio de Janeiro, Brazil.

Many snail species act as intermediate hosts of helminths that transmit diseases to humans and animals, such as schistosomiasis and angiostrongyliasis. São Gonçalo, a mostly urban municipality in Rio de Janeiro State, Brazil, has undergone fundamental environmental impacts, which favor the establishment of a range of diseases, for which snails act as the intermediate hosts of the etiological agents. In the present study, freshwater and terrestrial snail populations were surveyed in different environments within five city districts, and the presence of helminths was determined in the collected specimens. Read More

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http://dx.doi.org/10.1590/S1678-9946201860076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282505PMC
November 2018
2 Reads