35,545 results match your criteria Trematode Infection


A fine-scale phylogenetic assessment of digenean trematodes in central Alberta reveals we have yet to uncover their total diversity.

Ecol Evol 2019 Mar 28;9(6):3153-3238. Epub 2019 Feb 28.

School of Public Health University of Alberta Edmonton Alberta Canada.

Despite over 100 years of digenean trematode parasite species descriptions, from a wide diversity of vertebrate and invertebrate host species, our ability to recognize the diversity of trematode species within a single lake remains an incredible challenge. The most challenging aspect is the identification of species from larval stages derived from intermediate hosts, due to the disjointed data of adult worm morphological descriptions, from which species are named, and links to corresponding molecular identifiers in depauperate databases. Cryptic species also play a significant role in the challenge of linking trematode larvae to adults, species identifications, and estimating diversity. Read More

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http://dx.doi.org/10.1002/ece3.4939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434566PMC
March 2019
1 Read

The study of (): species-specific detection and phylogenetic relationship of , (Froelich, 1802).

J Parasit Dis 2019 Mar 20;43(1):66-74. Epub 2018 Nov 20.

Korean Association of Health Promotion, Seoul, South Korea.

is known as a significant intestinal trematode in various species of animals and humans. It presents complexities in terms of both the morphological and molecular biological data. This is the first study of the application of gene () as a target for studying the phylogeny and designing species-specific primer of . Read More

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http://link.springer.com/10.1007/s12639-018-1057-0
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http://dx.doi.org/10.1007/s12639-018-1057-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423160PMC
March 2019
6 Reads

Improving the specific diagnosis of trematode, cestode and nematode infections by a multiplex single-tube real-time PCR assay.

J Clin Pathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Aims: Helminth infections are becoming uncommon in high-income countries and laboratory staff may lose expertise in their morphological identification, especially in histological sections where speciation of helminths is challenging. Commercially available molecular diagnostic panels for faecal specimens only offer tests for protozoa but not helminths. We aim to improve the identification accuracy of helminths using a multiplex PCR assay. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205590DOI Listing
April 2019
2 Reads

IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase.

Rev Soc Bras Med Trop 2019 Mar 28;52:e20180139. Epub 2019 Mar 28.

Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.

Introduction: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase and Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence of particular epitopes shared between these proteins.

Methods: Potato apyrase was employed using ELISA, western blot, and mouse immunization methods to verify IgE reactivity.

Results: Most of the schistosomiasis patient's (75%) serum was seropositive for potato apyrase and this protein was recognized using western blotting, suggesting that parasite and plant proteins share IgE-binding epitopes. Read More

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http://dx.doi.org/10.1590/0037-8682-0139-2018DOI Listing
March 2019
3 Reads

A case report of human gastrodiscoidiasis in Nepal.

Parasitol Int 2019 Mar 26;71:56-58. Epub 2019 Mar 26.

Area de Parasitología, Departamento de Farmacia, Tecnología Farmacéutica y Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.

Gastrodiscoidiasis is a snail-transmitted zoonotic infection caused by the digenean trematode Gastrodiscoides hominis, which is the only species in the genus Gastrodiscoides infecting humans. We report a case of human gastrodiscoidiasis in a 66 years-old Nepali man without history of travels outside of Nepal who was admitted in the hospital with pain in upper abdomen for 4 months with history of passage of black-tarry stools, anemia and eosinophilia. During upper endoscopy a living trematode worm was seen in the antrum of the stomach. Read More

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http://dx.doi.org/10.1016/j.parint.2019.03.014DOI Listing
March 2019
1 Read
2.111 Impact Factor

Effects of pesticides on exposure and susceptibility to parasites can be generalised to pesticide class and type in aquatic communities.

Ecol Lett 2019 Mar 21. Epub 2019 Mar 21.

Department of Biological Sciences, Eck Institute for Global Health, and Environmental Change Initiative, University of Notre Dame, Notre Dame, IN, USA.

Pesticide pollution can alter parasite transmission, but scientists are unaware if effects of pesticides on parasite exposure and host susceptibility (i.e. infection risk given exposure) can be generalised within a community context. Read More

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http://dx.doi.org/10.1111/ele.13253DOI Listing
March 2019
2 Reads

Chance or choice? Understanding parasite selection and infection in multi-host communities.

Int J Parasitol 2019 Apr 17;49(5):407-415. Epub 2019 Mar 17.

Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.

Ongoing debate over the relationship between biodiversity and disease risk underscores the need to develop a more mechanistic understanding of how changes in host community composition influence parasite transmission, particularly in complex communities with multiple hosts. A key challenge involves determining how motile parasites select among potential hosts and the degree to which this process shifts with community composition. Focusing on interactions between larval amphibians and the pathogenic trematode Ribeiroia ondatrae, we designed a novel, large-volume set of choice chambers to assess how the selectivity of free-swimming infectious parasites varied among five host species and in response to changes in assemblage composition (four different permutations). Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456413PMC
April 2019
1 Read

In vivo fluorescent cercariae reveal the entry portals of Cardiocephaloides longicollis (Rudolphi, 1819) Dubois, 1982 (Strigeidae) into the gilthead seabream Sparus aurata L.

Parasit Vectors 2019 Mar 12;12(1):92. Epub 2019 Mar 12.

Cavanilles Institute for Biodiversity and Evolutionary Biology, Science Park, University of Valencia, P.O. Box 22 085, 46071, Valencia, Spain.

Background: Despite their complex life-cycles involving various types of hosts and free-living stages, digenean trematodes are becoming recurrent model systems. The infection and penetration strategy of the larval stages, i.e. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3351-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417200PMC
March 2019
6 Reads

Resistance and tolerance: A hierarchical framework to compare individual versus family-level host contributions in an experimental amphibian-trematode system.

Exp Parasitol 2019 Apr 9;199:80-91. Epub 2019 Mar 9.

Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, 80309, USA.

Hosts have two general strategies for mitigating the fitness costs of parasite exposure and infection: resistance and tolerance. The resistance-tolerance framework has been well developed in plant systems, but only recently has it been applied to animal-parasite interactions. However, difficulties associated with estimating fitness, controlling parasite exposure, and quantifying parasite burden have limited application of this framework to animal systems. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.03.001DOI Listing
April 2019
2 Reads

Morphology and molecules resolve the identity and life cycle of an eye trematode, Philophthalmus attenuatus n. sp. (Trematoda: Philophthalmidae) infecting gulls in New Zealand.

Parasitol Res 2019 Mar 12. Epub 2019 Mar 12.

Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand.

Trematodes of the genus Philophthalmus are cosmopolitan parasites that infect the eyes of birds and mammals. They have the potential to affect the survival of their hosts and a few cases of human philophthalmiasis have occurred worldwide. Adults of known Philophthalmus species have never been recorded from bird hosts in New Zealand, despite their cercarial stage being a focus of various studies. Read More

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http://dx.doi.org/10.1007/s00436-019-06289-8DOI Listing
March 2019
1 Read

An outbreak of schistosomiasis in a primary school in Omusati region, Namibia, March, 2016.

Pan Afr Med J 2018 16;30(Suppl 1). Epub 2018 May 16.

African Field Epidemiology Network, Accra, Ghana vc.

Schistosomiasis is endemic in some parts of northern Namibia and there is a control program in the country with the use of mass drug administration to control and prevent the disease. On the 1st March, 2016, there was a report of bloody urine among primary school pupils in a school in Omusati region, Namibia. A team of health professionals was dispatched to investigate. Read More

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http://www.panafrican-med-journal.com/content/series/30/1/5/
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http://dx.doi.org/10.11604/pamj.supp.2018.30.1.15263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379558PMC
March 2019
5 Reads

Within-host interactions shape virulence-related traits of trematode genotypes.

J Evol Biol 2019 Mar 9. Epub 2019 Mar 9.

Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland.

Within-host interactions between co-infecting parasites can significantly influence the evolution of key parasite traits, such as virulence (pathogenicity of infection). The type of interaction is expected to predict the direction of selection, with antagonistic interactions favouring more virulent genotypes and synergistic interactions less virulent genotypes. Recently, it has been suggested that virulence can further be affected by the genetic identity of co-infecting partners (G × G interactions), complicating predictions on disease dynamics. Read More

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http://doi.wiley.com/10.1111/jeb.13438
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http://dx.doi.org/10.1111/jeb.13438DOI Listing
March 2019
3 Reads

Professor Seung-Yull Cho (1943-2019).

Authors:
Yoon Kong

Korean J Parasitol 2019 Feb 26;57(1):77-78. Epub 2019 Feb 26.

Department of Molecular Parasitology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.

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http://dx.doi.org/10.3347/kjp.2019.57.1.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409226PMC
February 2019
4 Reads

Effect of Temperature on the Killing of Opisthorchis viverrini Eggs In Vitro.

Korean J Parasitol 2019 Feb 26;57(1):49-53. Epub 2019 Feb 26.

Department of Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Contaminated liver fluke egg in the environment has led to the high prevalence of human opisthorchiasis associated with cholangiocarcinoma in Southeast Asia. To find the effective lessening methods of Opisthorchis viverrini eggs in the contaminated environment, we investigated the temperature conditions for killing of these trematode eggs in vitro. Numerous O. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2019.57
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http://dx.doi.org/10.3347/kjp.2019.57.1.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409225PMC
February 2019
7 Reads

Necrotizing Enteritis Caused by Pharyngostomum cordatum Infection in a Stray Cat.

Korean J Parasitol 2019 Feb 26;57(1):17-20. Epub 2019 Feb 26.

Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.

A stray female cat of unknown age, presenting bright red watery diarrhea, was submitted to the Animal and Plant Quarantine Agency for diagnosis. In the small intestines extracted from the necropsied cat, numerous white oval-shaped organisms were firmly embedded in the mucosa and there was thickening of intestinal wall. Histopathological analysis revealed severe necrotizing enteritis, together with atrophied intestinal villi, exfoliated enterocytes, and parasitic worms. Read More

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http://dx.doi.org/10.3347/kjp.2019.57.1.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409222PMC
February 2019
6 Reads

MALDI-TOF mass spectrometry: a new tool for rapid identification of cercariae (Trematoda, Digenea).

Parasite 2019 6;26:11. Epub 2019 Mar 6.

EA 7510, ESCAPE, Laboratoire de Parasitologie-Mycologie, Université de Reims Champagne-Ardenne, 51 rue Cognacq Jay, 51092 Reims CEDEX, France - Laboratoire de Parasitologie Mycologie, CHU de Reims, Hôpital Maison Blanche, 45 rue Cognacq Jay, 51092 Reims CEDEX, France - USC ANSES Transmission vectorielle et épidémiosurveillance de maladies parasitaires (VECPAR), Reims, France.

Identification of cercariae was long based on morphological and morphometric features, but these approaches remain difficult to implement and require skills that have now become rare. Molecular tools have become the reference even though they remain relatively time-consuming and expensive. We propose a new approach for the identification of cercariae using MALDI-TOF mass spectrometry. Read More

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http://dx.doi.org/10.1051/parasite/2019011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402365PMC
March 2019
2 Reads

Benefits of annual chemotherapeutic control of schistosomiasis on the development of protective immunity.

BMC Infect Dis 2019 Mar 4;19(1):219. Epub 2019 Mar 4.

School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: Schistosomiasis is a devastating parasitic disease. The mainstay of schistosomiasis control is by praziquantel treatment. The study aimed to determine benefits of annual chemotherapy of schistosomiasis on development of protective immunity in school children in a selected endemic rural area in Zimbabwe. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3811-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398226PMC
March 2019
3 Reads
2.613 Impact Factor

Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales.

Vet Rec 2019 Apr 1;184(16):502. Epub 2019 Mar 1.

University of Liverpool Institute of Infection and Global Health, Liverpool, UK.

The liver fluke is a parasitic trematode that has a major impact on livestock production and human health. Control of is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. Read More

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http://dx.doi.org/10.1136/vr.105209DOI Listing
April 2019
1 Read

No limit in interspecific hybridization in schistosomes: observation from a case report.

Parasite 2019 1;26:10. Epub 2019 Mar 1.

Département de Parasitologie-Mycologie, Hôpital Avicenne AP-HP, Bobigny, France - Unité des Virus Emergents (Université Aix-Marseille- IRD 190 - Inserm 1207 - IHU Méditerranée infection), Marseille, France.

Schistosomiasis is one of the most significant parasitic diseases of humans. The hybridization of closely related Schistosoma species has already been documented. However, hybridization between phylogenetically distant species is unusual. Read More

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http://dx.doi.org/10.1051/parasite/2019010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396650PMC
March 2019
2 Reads

Survey of husbandry practices for bovidae in zoos: the importance of parasite management for reintroduction programmes.

Vet Rec 2019 Mar;184(9):282

Departamento de Ecología Funcional y Evolutiva, Estación Experimental de Zonas Áridas, Consejo Superior de Investigaciones Científicas, Almeria, Spain.

Animals from zoological institutions may be used for reintroductions. These individuals are considered healthy, but they are not necessarily free of parasites, despite the minimum husbandry standards required of zoological institutions as described in the European Association of Zoos and Aquaria guidelines. In this sense, parasitism has been identified as the cause of failure, or has added difficulties, in some reintroduction programmes. Read More

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http://dx.doi.org/10.1136/vr.104985DOI Listing
March 2019
1 Read

Spatiotemporal Patterns of Infection for Emerging Larval Liver Fluke ( Dicrocoelium dendriticum) in Three Species of Land Snail in Southern Alberta, Canada.

J Parasitol 2019 Feb;105(1):155-161

Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4.

The control of emerging parasites requires a fundamental knowledge of where and when rates of transmission are high. Data on spatiotemporal patterns of infection are challenging to obtain, particularly for complex life cycle parasites that involve transmission into multiple obligate hosts. The lancet liver fluke, Dicrocoelium dendriticum, has a long history of colonization outside its native host and geographical range in continental Europe. Read More

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February 2019
1 Read

Cumulative effects of municipal effluent and parasite infection in yellow perch: A field study using high-throughput RNA-sequencing.

Sci Total Environ 2019 May 13;665:797-809. Epub 2019 Feb 13.

Aquatic Contaminants Research Division, Water Science and Technology Directorate, Environment and Climate Change Canada, 105 McGill St., Montreal, QC H2E 2E7, Canada.

Multiple metabolic, immune and reproductive effects have been reported in fish residing in effluent-impacted sites. Natural stressors such as parasites also have been shown to impact the responses of organisms to chronic exposure to municipal effluent in the St. Lawrence River (Quebec, Canada). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.155DOI Listing

Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase.

Eur J Med Chem 2019 Apr 8;167:357-366. Epub 2019 Feb 8.

Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040-903, Brazil. Electronic address:

Schistosomiasis ranks second only to malaria as the most common parasitic disease worldwide. 700 million people are at risk and 240 million are already infected. Praziquantel is the anthelmintic of choice but decreasing efficacy has already been documented. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.018DOI Listing
April 2019
1 Read

Progenesis and facultative life cycle abbreviation in trematode parasites: Are there more constraints than costs?

Int J Parasitol 2019 Apr 14;49(5):347-354. Epub 2019 Feb 14.

Department of Biological Sciences, University of Alberta, Edmonton T6G 2E9, Alberta, Canada. Electronic address:

Complex life cycles provide advantages to parasites (longer life span, higher fecundity, etc.), but also represent a series of unlikely events for which many adaptations have evolved (asexual multiplication, host finding mechanisms, etc.). Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.11.009DOI Listing
April 2019
3 Reads

In vitro anthelmintic effect of biologically synthesized silver nanoparticles on liver amphistome, Gigantocotyle explanatum.

Exp Parasitol 2019 Mar 12;198:95-104. Epub 2019 Feb 12.

Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, India.

In order to ensure global food security a rationale approach is required to control all those factors which directly or indirectly affect the food productivity. The neglected helminthic diseases alone are responsible for huge economic losses to the agrarian stakeholders. The problem is further compounded by the emerging drug resistance in flukes against the commonly used anthelmintics like triclabendazole. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.02.005DOI Listing
March 2019
2 Reads

Schistosomiasis infection in pre-school aged children in Uganda: a qualitative descriptive study to identify routes of exposure.

BMC Infect Dis 2019 Feb 14;19(1):165. Epub 2019 Feb 14.

Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Prevalence of schistosomiasis is high among children under five years in Uganda. Schistosomiasis control efforts over time have included periodic mass treatments in endemic areas for adults and school going children aged 5 years and above. This study explores behaviour practices of children age 2-4 years that increase the risk of schistosomiasis infection in this age group. Read More

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http://dx.doi.org/10.1186/s12879-019-3803-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376787PMC
February 2019
5 Reads

Effect of Schistosoma mansoni infection and its treatment on antibody responses to measles catch-up immunisation in pre-school children: A randomised trial.

PLoS Negl Trop Dis 2019 02 14;13(2):e0007157. Epub 2019 Feb 14.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

Background: Schistosoma infection is associated with immune modulation that can influence responses to non-schistosome antigens. Vaccine responses may be impaired in S. mansoni-infected individuals. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007157
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http://dx.doi.org/10.1371/journal.pntd.0007157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392333PMC
February 2019
10 Reads

Freshwater snails as the intermediate host of trematodes in Iran: a systematic review.

Epidemiol Health 2019 7;41:e2019001. Epub 2019 Jan 7.

Department of Medical Parasitology and Mycology, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Freshwater snails, as the first intermediate hosts of trematodes, can cause health hazards in animals and humans. Recently, the World Health Organization has included Iran in a list of 6 countries known to have serious problems with fascioliasis. In addition, cercarial dermatitis is a job-related disease that is seen often in paddy workers, agricultural labourers, and fishermen in Iran, particularly in Mazandaran Province. Read More

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http://dx.doi.org/10.4178/epih.e2019001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446068PMC
April 2019
2 Reads

Comparing the performance of urine and copro-antigen detection in evaluating Opisthorchis viverrini infection in communities with different transmission levels in Northeast Thailand.

PLoS Negl Trop Dis 2019 02 8;13(2):e0007186. Epub 2019 Feb 8.

Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

To combat and eventually eliminate the transmission of the liver fluke Opisthorchis viverrini, an accurate and practical diagnostic test is required. A recently established urine antigen detection test using monoclonal antibody-based enzyme-linked-immunosorbent assay (mAb-ELISA) has shown promise due to its high diagnostic accuracy and the use of urine in place of fecal samples. To further test the utility of this urine assay, we performed a cross sectional study of 1,043 people in 3 opisthorchiasis endemic communities in northeast Thailand by applying urine antigen detection together with copro-antigen detection methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383950PMC
February 2019
2 Reads

Results of a national school-based deworming programme on soil-transmitted helminths infections and schistosomiasis in Kenya: 2012-2017.

Parasit Vectors 2019 Feb 7;12(1):76. Epub 2019 Feb 7.

Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

Background: Soil-transmitted helminth (STH) and schistosome infections are among the most prevalent neglected tropical diseases (NTDs) in the world. School-aged children are particularly vulnerable to these chronic infections that can impair growth, nutritional status and cognitive ability. Mass drug administration (MDA) delivered either once or twice annually is a safe and effective approach recommended by the World Health Organization (WHO) to reduce worm burden. Read More

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http://dx.doi.org/10.1186/s13071-019-3322-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367841PMC
February 2019
5 Reads

SWOT analysis on snail control measures applied in the national schistosomiasis control programme in the People's Republic of China.

Infect Dis Poverty 2019 Feb 6;8(1):13. Epub 2019 Feb 6.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.

Background: Snail control is an important component in the national schistosomiasis control programme in China, by application of chemical molluscicides, forestry projects, agriculture projects and water conservancy projects in recent decades. However, there are still wide areas of snail inhabited in China which remains a great challenge to achieve the goal of schistosomiasis elimination by 2025. Therefore, a SWOT (strengths, weaknesses, opportunities and threats) analysis on snail control measures is required for precision schistosomiasis control. Read More

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http://dx.doi.org/10.1186/s40249-019-0521-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367817PMC
February 2019
4 Reads

Knowledge, attitudes and practices with regard to schistosomiasis prevention and control: Two cross-sectional household surveys before and after a Community Dialogue intervention in Nampula province, Mozambique.

PLoS Negl Trop Dis 2019 02 7;13(2):e0007138. Epub 2019 Feb 7.

Departamento das Doenças Tropicais Negligenciadas, Ministério de Saúde, Maputo, Mozambique.

Background: The Community Dialogue Approach is a promising social and behaviour change intervention, which has shown potential for improving health seeking behaviour. To test if this approach can strengthen prevention and control of schistosomiasis at community level, Malaria Consortium implemented a Community Dialogue intervention in four districts of Nampula province, Mozambique, between August 2014 and September 2015.

Methodology/principal Findings: Cross-sectional household surveys were conducted before (N = 791) and after (N = 792) implementation of the intervention to assess its impact on knowledge, attitudes and practices at population level. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382216PMC
February 2019
1 Read

The ABL kinase inhibitor imatinib causes phenotypic changes and lethality in adult Schistosoma japonicum.

Parasitol Res 2019 Mar 7;118(3):881-890. Epub 2019 Feb 7.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, People's Republic of China.

Schistosomiasis caused by different species of schistosome parasites is one of the most debilitating helminthic diseases of humans worldwide. For decades, chemotherapy is the main method of controlling schistosomiasis. However, the fear of drug resistance has motivated the search for alternatives. Read More

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http://dx.doi.org/10.1007/s00436-019-06224-xDOI Listing
March 2019
4 Reads

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Infections.

Antimicrob Agents Chemother 2019 Apr 27;63(4). Epub 2019 Mar 27.

Swiss Tropical and Public Health Institute, Basel, Switzerland

Opisthorchiasis, caused by the foodborne trematode , affects more than 8 million people in Southeast Asia. In the framework of a phase 2b clinical trial conducted in Lao People's Democratic Republic, pharmacokinetic samples were obtained from 125 adult and adolescent -infected patients treated with 400 mg tribendimidine following the design of a sparse sampling scheme at 20 min and 2, 7.75, 8, and 30 h after treatment using dried blood spot sampling. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01391-18
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http://dx.doi.org/10.1128/AAC.01391-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437521PMC
April 2019
4 Reads

Identification and characterization of glyceraldehyde 3-phosphate dehydrogenase from Fasciola gigantica.

Parasitol Res 2019 Mar 31;118(3):861-872. Epub 2019 Jan 31.

Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Shillong, 793022, India.

Fasciola gigantica is an important food-borne trematode responsible for the hepatobiliary disease, commonly known as fascioliasis. In F. gigantica, the glyceraldehyde 3-phosphate dehydrogenase (FgGAPDH) is a key enzyme of the glycolytic pathway and catalyzes the reversible oxidative phosphorylation of D-glyceraldehyde-3-phosphate (G-3-P) to 1,3-bisphosphoglycerate (1,3-BPG), with the simultaneous reduction of NAD to NADH. Read More

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http://link.springer.com/10.1007/s00436-019-06225-w
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http://dx.doi.org/10.1007/s00436-019-06225-wDOI Listing
March 2019
12 Reads

Effectiveness of as a controller of in experimental infections of .

Trop Parasitol 2018 Jul-Dec;8(2):88-93. Epub 2018 Dec 27.

Regional Parasitology Research Center Inka (CIPRI), Cusco, Peru.

Background: is an annelid symbiotically associated with lymnaeid snails as . This association is considered a preventive mechanism against trematode miracidia infection, including . The objective of this study was to determine the effectiveness of as a natural controller of in laboratory conditions. Read More

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http://dx.doi.org/10.4103/tp.TP_24_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329262PMC
December 2018
1 Read

Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23.

Parasit Vectors 2019 Jan 28;12(1):63. Epub 2019 Jan 28.

Janssen Diagnostics, Janssen R&D, Turnhoutseweg 30, 2340, Beerse, Belgium.

Background: Ov16 serology is considered a reference method for Onchocerca volvulus epidemiological mapping. Given the suboptimal sensitivity of this test and the fact that seroconversion takes more than a year after infection, additional serological tests might be needed to guide onchocerciasis elimination programmes. Recently, two linear epitopes encoded in OvMP-1 and OvMP-23 peptides were introduced as serological markers, but the observed antibody cross-reactivity in samples originating from Onchocerca volvulus non-endemic areas required further investigation. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350367PMC
January 2019
19 Reads

Population genetic structure of Schistosoma bovis in Cameroon.

Parasit Vectors 2019 Jan 24;12(1):56. Epub 2019 Jan 24.

Université de Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Université de Montpellier, F-66860, Perpignan, France.

Background: Schistosomiasis is neglected tropical parasitic disease affecting both humans and animals. Due to the human health impact, population genetic studies have focused on the three main human-infecting schistosome species: Schistosoma mansoni, S. haematobium and S. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3307-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346511PMC
January 2019
5 Reads

Immunological Parameters of the Pomacea lineata Spix, 1827 (Mollusca: Caenogastropoda) Exposed to Schistosoma mansoni Sambon, 1907.

Acta Parasitol 2019 Mar 22;64(1):31-43. Epub 2019 Jan 22.

Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, UFRPE-DMFA, Av. Dom Manoel de Medeiros s/n Dois, s/n, Dois Irmãos District, Recife, PE, 52171-900, Brazil.

Introduction: Pomacea lineata acts as the natural biological controller of Biomphalaria glabrata, the intermediate host of Schistosoma mansoni, as they are found in the same environment. However, there are no studies reporting an infection in P. lineata due to S. Read More

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http://dx.doi.org/10.2478/s11686-018-00005-9DOI Listing

A Biomphalaria glabrata peptide that stimulates significant behaviour modifications in aquatic free-living Schistosoma mansoni miracidia.

PLoS Negl Trop Dis 2019 01 22;13(1):e0006948. Epub 2019 Jan 22.

School of Science and Education, Genecology Research Centre, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia.

The human disease schistosomiasis (or bilharzia) is caused by the helminth blood fluke parasite Schistosoma mansoni, which requires an intermediate host, the freshwater gastropod snail Biomphalaria glabrata (the most common intermediate host). The free-swimming parasite miracidia utilise an excellent chemosensory sense to detect and locate an appropriate host. This study investigated the biomolecules released by the snail that stimulate changes in the behaviour of the aquatic S. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358113PMC
January 2019
2 Reads

Prevalence of bovine fascioliasis and economic impact associated with liver condemnation in abattoirs in Mongu district of Zambia.

BMC Vet Res 2019 Jan 21;15(1):33. Epub 2019 Jan 21.

Department of Veterinary Services, Mulungushi House, Lusaka, Zambia.

Background: Fascioliasis is a trematode zoonotic snail-borne disease of public health and economic importance. The disease causes liver damage and is hardly recognized by medical personnel hence, is rarely considered as the differential diagnosis. In animals, the disease leads to mortalities, growth retardation, drop in livestock production and condemnation of the infected livers during meat inspection. Read More

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http://dx.doi.org/10.1186/s12917-019-1777-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341647PMC
January 2019
9 Reads

Albendazole, levamisole and ivermectin are effective against monogeneans of Colossoma macropomum (Pisces: Serrasalmidae).

J Fish Dis 2019 Mar 18;42(3):405-412. Epub 2019 Jan 18.

Postgraduate Program in Environmental Sciences (PPGCA), Federal University of Amapá (UNIFAP), Macapá, Brazil.

This study evaluated the efficacy of albendazole, ivermectin, levamisole, mebendazole and praziquantel on monogeneans of Colossoma macropomum, based on in vitro and in vivo assays. In vitro assays indicated that albendazole (500, 100, 1,500 and 2,000 mg/L), ivermectin (200, 250, 300 and 350 mg/L) and levamisole (50, 75, 100 and 125 mg/L) were 100% effective against Anacanthorus spatulatus, Notozothecium janauachensis, Mymarothecium boegeri and Linguadactyloides brinkmanni, while mebendazole (125, 150, 175 and 200 mg/L) and praziquantel (5, 10, 15 and 20 mg/L) were ineffective. Fish mortality in 24 hr therapeutic baths with 500 mg/L of albendazole was 6. Read More

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http://dx.doi.org/10.1111/jfd.12952DOI Listing
March 2019
1 Read

The epidemiology and chemotherapeutic approaches to the control of urinary schistosomiasis in school-age children (SAC): a systematic review.

BMC Infect Dis 2019 Jan 18;19(1):73. Epub 2019 Jan 18.

Department of Biological Sciences and Biotechnology, College of Pure and Applied Sciences, Caleb University, Imota, Lagos State, Nigeria.

Background: Human schistosomiases are acute and chronic infectious diseases of poverty. Currently, epidemiological data of urinary schistosomiasis (US) in school-age children (SAC) and adults are often reported together making it difficult to ascertain the true status of the disease. Based on this premise, we set out to carry out this review. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3647-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339440PMC
January 2019
5 Reads

Transcriptomic analysis of reduced sensitivity to praziquantel in Schistosoma mansoni.

Mol Biochem Parasitol 2019 03 15;228:6-15. Epub 2019 Jan 15.

Dept. of Biology, University of New Mexico, Albuquerque, NM, USA. Electronic address:

Schistosomiasis is an intravascular parasitic infection estimated to affect over 206 million people, the majority of whom live in Africa where the trematode worms Schistosoma mansoni and Schistosoma haematobium are the major causative agents. While a number of drugs have been used to treat schistosomiasis, praziquantel (PZQ) is the only one that is widely available, relatively cheap, and easy to use. The reliance on a single drug for the treatment of such a prevalent disease is a cause for concern due to the potential for resistance to render PZQ ineffective. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01666851183020
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http://dx.doi.org/10.1016/j.molbiopara.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372308PMC
March 2019
6 Reads

Prevalence of urodynamic changes with risk for upper urinary tract damage in neuroschistosomiasis patients.

Rev Soc Bras Med Trop 2019 01 17;52:e20180101. Epub 2019 Jan 17.

Departamento de Ginecologia e Obstetrícia, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brasil.

Introduction: This study aimed to identify the prevalence of urodynamic changes with an associated risk of developing upper urinary tract damage in neuroschistosomiasis patients.

Methods: A prospective study was conducted, wherein68 patients were admitted for analysis of urodynamics, urea and creatinine levels, and uroculture.

Results: Blood test results did not indicate kidney failure. Read More

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http://dx.doi.org/10.1590/0037-8682-0101-2018DOI Listing
January 2019
2 Reads

The cost of a disease targeted for elimination in Brazil: the case of schistosomiasis mansoni.

Mem Inst Oswaldo Cruz 2019 Jan 14;114:e180347. Epub 2019 Jan 14.

Universidade de Brasília, Núcleo de Medicina Tropical, Brasília, DF, Brasil.

Background: Schistosomiasis mansoni is a poverty-related parasitic infection that has a variety of clinical manifestations. We consider the disability and deaths caused by schistosomiasis unacceptable for a tool-ready disease. Its condition in Brazil warrants an analysis that will enable better understanding of the local health losses and contribute to the complex decision-making process. Read More

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http://dx.doi.org/10.1590/0074-02760180347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340134PMC
January 2019
2 Reads

A new genus and species of the Dasybatotreminae Bychowsky, 1957 (Monogenea: Monocotylidae), parasitic on Hypanus dipterurus (Jordan Gilbert) (Myliobatiformes: Dasyatidae) in the Southeastern Pacific Ocean off Peru.

Zootaxa 2018 Dec 6;4527(3):347-356. Epub 2018 Dec 6.

Programa de Pós-Graduação em Biologia Animal da Universidade Federal Rural do Rio de Janeiro, BR 465, Km 7, CEP 23890-000, Seropédica, Rio de Janeiro, Brazil. Laboratorio de Parasitología General y Especializada, Facultad de Ciencias Naturales y Matemática, Universidad Nacional Federico Villarreal (UNFV), Código postal 15007, El Agustino, Lima, Perú..

Peruanocotyle n. gen. is proposed to accommodate Peruanocotyle chisholmae n. Read More

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http://dx.doi.org/10.11646/zootaxa.4527.3.4DOI Listing
December 2018
2 Reads

Diagnostic Value of SjR2 Gene in Colonic Tissue from Schistosoma Japonicum Infected Hosts.

Med Sci Monit 2019 Jan 14;25:427-435. Epub 2019 Jan 14.

Department of Parasitology, Xiangya School of Medicine, Central South University (CSU), Changsha, Hunan, China (mainland).

BACKGROUND The prevalence and intensity of schistosomiasis infection in China has decreased markedly in recent years. Therefore, more accurate methods are critically needed to ensure further control of low-intensity schistosomiasis infection. For chronic schistosomiasis patients, the detection of schistosome eggs in colorectal mucosa tissues is commonly used. Read More

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http://dx.doi.org/10.12659/MSM.912997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342060PMC
January 2019
2 Reads

Fasciola gigantica: Comparison of the tegumental ultrastructure in newly excysted metacercariae and in vitro penetrated juvenile flukes indicates intracellular sources of molecules with vaccinal and immunomodulatory potential.

Vet Parasitol 2019 Jan 7;265:38-47. Epub 2018 Dec 7.

School of Biological Sciences, The Queen's University of Belfast, Belfast, BT9 7BL, United Kingdom.

Using in vitro procedures to prepare newly excysted metacercariae and gut-penetrated juvenile Fasciola gigantica, the ultrastructural features of the tegumental syncytium and perikarya of these ephemeral stages in the host-invasion process were compared. The T0-type tegumental cells in newly excysted metacercariae are packed with stored T0 granules which, following transport to the surface membrane of the syncytium, discharge by exocytosis to maintain the glycocalyx. The T0 cells become depleted of T0 granules during the penetration process, shrink in size, and initiate autophagy in the cytoplasm to facilitate metamorphosis from a storage function to active biosynthesis. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.019DOI Listing
January 2019
4 Reads

NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB.

Parasit Vectors 2019 Jan 11;12(1):29. Epub 2019 Jan 11.

Department of Parasitology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, Hubei, People's Republic of China.

Background: NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inflammasome inhibitor, MCC950, to investigate whether it inhibited liver fibrosis, and explored the preliminary molecular mechanism.

Methods: BALB/c mice were infected with 15 cercariae through the abdominal skin. Read More

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http://dx.doi.org/10.1186/s13071-018-3223-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330481PMC
January 2019
5 Reads