50,109 results match your criteria Travel Medicine and Vaccination


Daily energy expenditure of males following alternative reproductive tactics: Solitary roamers spend more energy than group-living males.

Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.

School of Animal, Plant & Environmental Sciences, University of the Witwatersrand, Private Bag 3, WITS, 2050 Johannesburg, South Africa; IPHC, UNISTRA, CNRS, 23 rue du Loess, 67200 Strasbourg, France.

In many species, males follow alternative reproductive tactics (ARTs), where one tactic (called bourgeois) has much higher reproductive success than alternative tactics followed by males with lower competitive ability. The extent to which ARTs differ in energetic costs is unknown, but it is important to understand the fitness payoffs of ARTs. We studied male African striped mice (Rhabdomys pumilio) which follow one of three ARTs: heavy bourgeois males defend harems of females and have 10 times higher reproductive success than smaller roamers, which have ten times higher reproductive success than philopatric males, which remain in their natal group and are the smallest males. Read More

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December 2018
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Shining Sunlight on Industry Payments in Oral and Maxillofacial Surgery: The Sunshine Act.

J Oral Maxillofac Surg 2018 Nov 12. Epub 2018 Nov 12.

Assistant Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA.

Purpose: To characterize industry payments to oral and maxillofacial surgeons (OMSs) and to determine the accuracy of the Centers for Medicare and Medicaid Services (CMS) Open Payments Databases.

Materials And Methods: This was a cross-sectional study of the CMS General and Research Payments Databases in 2016 for clinicians categorized as OMSs. General payments include consulting fees, honoraria, gifts, entertainment, food and beverage, travel and education, and others. Read More

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November 2018
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Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study.

PLoS One 2018 6;13(12):e0207707. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members. Read More

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December 2018
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Integrated Aedes management for the control of Aedes-borne diseases.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006845. Epub 2018 Dec 6.

MIVEGEC, IRD, CNRS, University of Montpellier, Montpellier, France.

Background: Diseases caused by Aedes-borne viruses, such as dengue, Zika, chikungunya, and yellow fever, are emerging and reemerging globally. The causes are multifactorial and include global trade, international travel, urbanisation, water storage practices, lack of resources for intervention, and an inadequate evidence base for the public health impact of Aedes control tools. National authorities need comprehensive evidence-based guidance on how and when to implement Aedes control measures tailored to local entomological and epidemiological conditions. Read More

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December 2018
2 Reads

Pseudoephedrine at international borders: advising the unwary traveller.

J Travel Med 2018 Dec 6. Epub 2018 Dec 6.

School of Medicine, National University of Ireland Galway, Galway, Ireland.

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December 2018

Strongyloides stercoralis infection in a migrant on dialysis.

J Travel Med 2018 Dec 6. Epub 2018 Dec 6.

Centre for Tropical Diseases, IRCCS Sacro Cuore Don Calabria hospital, Via Sempreboni 5, 37024 Negrar, Verona, Italy.

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December 2018

Venezuela's migration crisis: a growing health threat to the region requiring immediate attention.

J Travel Med 2018 Dec 6. Epub 2018 Dec 6.

Infectious Diseases Section, Tropical Medicine Institute, Universidad Central de Venezuela.

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December 2018

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

Health Technol Assess 2018 Dec;22(70):1-82

Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Background: Asthma exacerbations affect the quality of life of patients with asthma and have a major effect on the overall costs of asthma care. An asthma self-management plan that advises the temporary quadrupling of inhaled corticosteroid dose may prevent asthma exacerbations, but this needs to be confirmed before being adopted widely.

Objectives: To compare the clinical effectiveness and cost-effectiveness of an asthma self-management plan that advises patients to temporarily quadruple the dose of inhaled corticosteroid when asthma control starts to deteriorate with a standard self-management plan. Read More

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December 2018

Direct Oral Anticoagulants and Travel-related Venous Thromboembolism.

Open Med (Wars) 2018 27;13:575-582. Epub 2018 Nov 27.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Ext 80252, Thailand.

Travel- related thromboembolism reflects the relationship between venous thromboembolism (VTE) and long-haul flights. Although this condition is rare, it may cause significant morbidity and mortality. Therefore, travelers should be evaluated for the risks for thrombosis. Read More

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November 2018

Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts.

Burns Trauma 2018 27;6:33. Epub 2018 Nov 27.

Pegg Leditschke Children's Burns Centre, Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland Australia.

Background: This is a parallel three-arm prospective randomised controlled trial (RCT) comparing Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts (STSG). All three were in current use within the Pegg Leditschke Children's Burn centre (PLCBC), the largest paediatric burns centre in Queensland, Australia. Our objective was to find the best performing dressing, following on from previous trials designed to rationalise dressings for the burn wound itself. Read More

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November 2018
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Patient Preferences Regarding Chemotherapy in Metastatic Breast Cancer-A Conjoint Analysis for Common Taxanes.

Front Oncol 2018 21;8:535. Epub 2018 Nov 21.

Department of Obstetrics and Gynaecology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.

The purpose of this investigation was to explore patient perception regarding the importance of efficacy, toxicity, and logistics in the choice of regimen of taxane-based chemotherapy (CHT) for patients with metastatic breast cancer (MBC). This dual-center study analyzed data of 100 women diagnosed with MBC, who were asked for their preferences regarding chemotherapy by means of conjoint analysis. Included attributes were progression free survival (PFS), application form, time and frequency, need of premedication, risk of alopecia, fatigue, febrile neutropenia, and neuropathy. Read More

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November 2018

German National Case Collection for familial pancreatic Cancer (FaPaCa) - acceptance and psychological aspects of a pancreatic cancer screening program.

Hered Cancer Clin Pract 2018 29;16:17. Epub 2018 Nov 29.

1Department of Visceral-, Thoracic- and Vascular Surgery, National Case Collection for Familial Pancreatic Cancer (FaPaCa), Philipps-University Marburg, Baldingerstrasse, 35043 Marburg, Germany.

Background: Pancreatic cancer screening is recommended to individuals at risk (IAR) of familial pancreatic cancer (FPC) families, but little is known about the acceptance of such screening programs. Thus, the acceptance and psychological aspects of a controlled FPC screening program was evaluated.

Methods: IAR of FPC families underwent comprehensive counseling by a geneticist and pancreatologist prior to the proposed screening. Read More

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November 2018

First clinical experiences of concurrent bleeding control and intracranial pressure monitoring using a hybrid emergency room system in patients with multiple injuries.

World J Emerg Surg 2018 29;13:56. Epub 2018 Nov 29.

Division of Trauma and Surgical Critical Care, Osaka General Medical Center, 3-1-56 Bandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558 Japan.

Background: The outcomes of multiple injury patients with concomitant torso hemorrhage and traumatic brain injury (TBI) are very poor. The hybrid emergency room system (HERS) is a trauma management system designed to complete resuscitation, computed tomography (CT), surgery, angioembolization, and intracranial pressure (ICP) monitoring all in one trauma resuscitation room without patient transfer. We aimed to review the outcomes of polytrauma patients who underwent concurrent bleeding control and ICP monitoring using the HERS. Read More

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November 2018
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SuperPolymyxin™ Medium for the Screening of Colistin-Resistant Gram-Negative Bacteria in Stool Samples.

Front Microbiol 2018 21;9:2809. Epub 2018 Nov 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Colistin is one of the last resort antimicrobials for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. After the emergence of transferable colistin resistance genes (-1-5), a reliable culture-based screening method to detect colonization with colistin-resistant Gram-negative bacteria (CRGN) is needed. The objective of this study was to test the performance of SuperPolymyxin™ medium to screen for CRGN in stool samples and to compare different methods for the confirmation of colistin resistance (e. Read More

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November 2018

Aripiprazole in acute treatment of children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.

Neuropsychiatr Dis Treat 2018 12;14:3063-3072. Epub 2018 Nov 12.

Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand,

Background: Recent randomized controlled trials indicated that aripiprazole was the effective treatment for children and adolescents with autism spectrum disorder (ASD).

Objective: This study systematically reviewed the efficacy, acceptability and tolerability of aripiprazole in treatment of ASD children and adolescents.

Data Sources: Electronic search of databases including, Scopus, PubMed, CINAHL and Cochrane Controlled Trials Register was performed in July 2017. Read More

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November 2018
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Treatment of relapsed refractory multiple myeloma: which new PI-based combination treatments do patients prefer?

Patient Prefer Adherence 2018 9;12:2387-2396. Epub 2018 Nov 9.

Asklepios Kliniken Hamburg GmbH, 22763 Hamburg, Germany.

Background And Objectives: This study describes preferences of German relapsed refractory multiple myeloma (RRMM) patients with novel proteasome inhibitor-based combination treatments.

Methods: Patients with a minimum age of 18 years and a diagnosis of RRMM were included. Their preferences were assessed using a discrete choice experiment design, which was developed based on a literature review and two patient focus group discussions. Read More

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November 2018
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Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study.

BMJ 2018 Dec 5;363:k4764. Epub 2018 Dec 5.

Harvard Medical School, Boston, MA, USA.

Objective: To determine whether medical errors, family experience, and communication processes improved after implementation of an intervention to standardize the structure of healthcare provider-family communication on family centered rounds.

Design: Prospective, multicenter before and after intervention study.

Setting: Pediatric inpatient units in seven North American hospitals, 17 December 2014 to 3 January 2017. Read More

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December 2018

Do probiotics prevent colonization with multi-resistant Enterobacteriaceae during travel? A randomized controlled trial.

Travel Med Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Aarhus University Hospital, Department of Infectious Diseases, Aarhus, Denmark.

Background: Travelers to India are often colonized with extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) or Carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to investigate if the probiotic species Lactobacillus Rhamnosus GG (LGG) could prevent the colonization of the gut with multi-drug resistant bacteria.

Methods: Adult Danish travelers traveling to India for 10-28 days were randomized to receive either LGG or no probiotics during travel. Read More

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November 2018

Receipt of sentinel lymph node biopsy for thin melanoma is associated with distance traveled for care.

J Surg Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Sentinel lymph node biopsy (SLNB) is not routinely recommended for thin melanoma. However, it is considered when high-risk features, clinicopathological, or sociodemographic, are present. It was our objective to evaluate the impact of travel distance on decision-making for SLNB in thin melanoma. Read More

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December 2018

Sentinel Surveillance in Travel Medicine: Twenty Years of GeoSentinel Publications (1999-2018).

J Travel Med 2018 Dec 3. Epub 2018 Dec 3.

Tropical Disease Unit, Toronto General Hospital, Canada.

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December 2018

The experience of parents with children with myelomeningocele who underwent prenatal surgery.

J Pediatr Rehabil Med 2018 Nov 18. Epub 2018 Nov 18.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Prenatal surgery for myelomeningocele (MMC) has been demonstrated to have benefits over postnatal surgery. Nevertheless, prenatal surgery requires a significant emotional, physical, and financial commitment from the entire family.

Methods: Mixed methods study of parents' perceptions regarding provider communication, treatment choices, and the family impact of having a child with MMC. Read More

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November 2018

Scene Transitions and Teleportation in Virtual Reality and the Implications for Spatial Awareness and Sickness.

IEEE Trans Vis Comput Graph 2018 Nov 30. Epub 2018 Nov 30.

Various viewing and travel techniques are used in immersive virtual reality to allow users to see different areas or perspectives of 3D environments. Our research evaluates techniques for visually showing transitions between two viewpoints in head-tracked virtual reality. We present four experiments that focus on automated viewpoint changes that are controlled by the system rather than by interactive user control. Read More

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November 2018

Global burden of tuberculosis: where we are and what to do.

Lancet Infect Dis 2018 Dec;18(12):1291-1293

Ministry of Health, Lusaka, Zambia; Zambia National Public Health Institute, Lusaka, Zambia.

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December 2018

Men on the Move: A Randomized Controlled Feasibility Trial of a Scalable, Choice-Based Physical Activity and Active Transportation Intervention for Older Men.

J Aging Phys Act 2018 Dec 3:1-45. Epub 2018 Dec 3.

2 University of British Columbia, Vancouver, BC, Canada.

We conducted Men on the Move, a 12-week randomized controlled feasibility trial of a scalable, choice-based physical activity (PA) and active transportation intervention. Participants were community-dwelling men aged 60+ years (n=29 intervention (INT), n=29 waitlist control (CON)). Trained activity coaches delivered: 1) one-on-one participant consultations to develop personal action plans for PA and active transportation; 2) monthly group-based motivational meetings; 3) weekly telephone support; 4) complimentary recreation and transit passes; and 5) pedometers and diaries for self-monitoring. Read More

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December 2018

Nutrition for Travel- from Jetlag to Catering.

Int J Sport Nutr Exerc Metab 2018 Dec 3:1-24. Epub 2018 Dec 3.

4 High Performance Sport New Zealand.

Domestic and international travel represents a regular challenge to high performance track and field athletes, particularly when associated with the pressure of competition or the need to support specialized training (e.g. altitude or heat adaptation). Read More

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December 2018
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A comparative study of patients' perceptions of genetic and genomic medicine services in California and Malaysia.

J Community Genet 2018 Dec 3. Epub 2018 Dec 3.

Department of Genetic and Genomic Medicine, University of California Irvine, Irvine, CA, 92697, USA.

In the era of personalized and genomic medicine, awareness of patients with rare diseases is increasing as new approaches to diagnosis and treatment are developed. This study examined perceived barriers experienced by families with rare diseases and explored possible differences between participants in Malaysia and California, USA. The study involved N = 108 participants recruited in genetics clinic appointments at the University of Malaya Medical Center and three sites in Southern California. Read More

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December 2018

Improvement and evaluation of loop-mediated isothermal amplification combined with a chromatographic flow dipstick assay and utilization in detection of Vibrio cholerae.

Anal Bioanal Chem 2018 Dec 1. Epub 2018 Dec 1.

School of Medicine, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin, 300071, China.

Loop-mediated isothermal amplification (LAMP) is a specific, sensitive, and easy-to-perform nucleic acid analytical technique with wide application for diagnosis of disease. Recently, LAMP combined with use of a lateral chromatographic flow dipstick (LFD) has been widely used in nucleic acid detection. However, the LFD mechanism has not been systematically analyzed, and the optimal combination of labeled primers has not been adequately evaluated. Read More

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December 2018

A cross-sectional study to assess the awareness and practices related to adult immunization among nursing students in a metropolitan city.

J Educ Health Promot 2018 29;7:129. Epub 2018 Oct 29.

Department of Community Medicine, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Introduction: Immunization against vaccine-preventable diseases in adults is the need of the hour. The student nurses by virtue of training are the frontline health workers dealing with patient care. They are exposed to maximum risk of contracting the diseases. Read More

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October 2018
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Implementing tumor mutational burden (TMB) analysis in routine diagnostics-a primer for molecular pathologists and clinicians.

Transl Lung Cancer Res 2018 Dec;7(6):703-715

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Tumor mutational burden (TMB) is a new biomarker for prediction of response to PD-(L)1 treatment. Comprehensive sequencing approaches (i.e. Read More

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December 2018

Clinical utility of tumor mutational burden in patients with non-small cell lung cancer treated with immunotherapy.

Transl Lung Cancer Res 2018 Dec;7(6):647-660

Department of Cancer Medicine, Gustave Roussy, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Villejuif, France.

Anti-programmed death (ligand)-1 [anti-PD-(L)1] therapies such as pembrolizumab, nivolumab or atezolizumab have become standard of care for non-small cell lung cancer (NSCLC) patients either in first line or beyond. PD-L1 expression level allows enriching the treated population with responders, but it is still not an optimal biomarker. Even in patients with PD-L1 tumor proportion score (TPS) levels of ≥50% treated with first line pembrolizumab overall response rate (ORR) is only 44. Read More

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December 2018
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An approach to validate groundwater contamination risk in rural mountainous catchments: the role of lateral groundwater flows.

MethodsX 2018 7;5:1447-1455. Epub 2018 Nov 7.

Department of Civil Engineering, University of Trás-os-Montes and Alto Douro, Ap. 1013, 5001-801 Vila Real, Portugal.

Computer models dedicated to the validation of groundwater contamination risk in the rural environment, namely the risk of contamination by nitrate leachates from agriculture fertilizers, are frequently based on direct comparison of risky areas (e.g., cropland, pastures used for livestock production) and spatial distributions of contaminant (nitrate) plumes. Read More

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November 2018

Encouraging active travel to improve health and save money.

Authors:
Glenn Stewart

BMJ 2018 Nov 30;363:k4980. Epub 2018 Nov 30.

Directorate of Public Health, London Borough of Enfield, Enfield EN1 3XA, UK.

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November 2018

Mining Open Payments Data: Analysis of Industry Payments to Thoracic Surgeons From 2014-2016.

J Med Internet Res 2018 Nov 30;20(11):e11655. Epub 2018 Nov 30.

Institute of Medical Information / Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: The financial relationship between physicians and industries has become a hotly debated issue globally. The Physician Payments Sunshine Act of the US Affordable Care Act (2010) promoted transparency of the transactions between industries and physicians by making remuneration data publicly accessible in the Open Payments Program database. Meanwhile, according to the World Health Organization, the majority of all noncommunicable disease deaths were caused by cardiovascular disease. Read More

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November 2018

Regulation of Root-Knot Nematode Behavior by Seed Coat Mucilage-Derived Attractants.

Mol Plant 2018 Nov 29. Epub 2018 Nov 29.

Graduate School of Science & Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan. Electronic address:

Seed exudates influence the behaviour of soil organisms, but how this occurs remains unclear, particularly for multicellular animals. Here we show that compounds associated with Arabidopsis seed coat mucilage regulate the behaviour of soil-borne animals, specifically root-knot nematodes (RKN). Infective RKN J2 larvae actively travel toward Arabidopsis seeds through chemotaxis. Read More

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November 2018
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Fostering trust in healthcare: Participants' experiences, views, and concerns about the 100,000 genomes project.

Eur J Med Genet 2018 Nov 29. Epub 2018 Nov 29.

Clinical Ethics and Law at Southampton (CELS), Faculty of Medicine University of Southampton, United Kingdom. Electronic address:

In this paper, we present findings from a project involving 20 patients with rare diseases, or parents thereof, participating in the 100,000 genomes project (100 kG P) about their experiences of, and views about, the project, including why they took part, and their hopes and concerns about the future of genomic medicine. Patients who attended genetic clinics for testing were offered the opportunity to undergo the more extensive whole genome sequencing (WGS) if they agreed to take part in the 100 kG P. Once people had agreed, a specific additional appointment was organised for them; taking part in the project therefore involved additional travel and appointments. Read More

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November 2018

Prisms for timing better: A review on application of prism adaptation on temporal domain.

Cortex 2018 Nov 1. Epub 2018 Nov 1.

Istituti Clinici Scientifici Maugeri, Hospital IRCCS, Castel Goffredo, Italy; Department of Psychology, University of Bologna, Bologna, Italy. Electronic address:

The possibility to induce a transient modulation of visuo-spatial attention boosted so far the implementation of the prism adaptation in a variety of domains. This sensorimotor technique has been adopted to investigate the neural plasticity in neurologically healthy individuals, as well as to ameliorate deficit of visuo-spatial attention (which characterizes neglect patients' performance). We review here evidence about a new promising application of prisms in exploring how the human brain represents the subjective time flow on a spatially oriented "mental time line". Read More

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November 2018
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Inpatient treatment of trekkers and Nepalese workers in the high-altitude environment of region 1996-2011: A retrospective analysis.

Travel Med Infect Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Occupational, Social and Environmental Medicine, RWTH Aachen University, Aachen, Germany; Department of Dental Preservation, Parodontology& Preventive Dentistry, RWTH Aachen Technical University, Aachen, Germany. Electronic address:

Background: The study investigates the diagnoses of inpatients (tourists and Nepali workers) of Kunde Hospital (Mt.Everest region) over 15 years.

Methods: Records from January 1996 to September 2011 were analyzed concerning date, gender, age group, nationality, purpose of visit, diagnosis, length of treatment, and condition at discharge. Read More

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November 2018

Quantifying disparities in access to public-sector abortion based on legislative differences within the Mexico City metropolitan area.

Contraception 2018 Nov 28. Epub 2018 Nov 28.

National Institute of Public Health, Center for Population Health Research Cuernavaca, Morelos, Mexico; Department of Obstetrics & Gynecology, Oregon Health & Science University & OHSU-PSU School of Public Health, Portland, OR, USA. Electronic address:

Objectives: In the Mexico City Metropolitan Area, only women in the city center have local access to legal first trimester abortion. We quantify how this legislative discrepancy affects access to legal, public-sector abortion across the metropolitan area.

Study Design: In this observational study we used a dataset representing 67. Read More

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November 2018
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Long-term pneumococcal vaccine immunogenicity following allogeneic hematopoietic stem cell transplantation.

Vaccine 2018 Nov 27. Epub 2018 Nov 27.

Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, the Netherlands. Electronic address:

Infection with Streptococcus pneumoniae is a life-threatening, but vaccine preventable complication in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). The international consensus on post allo-HSCT immunization schedules, starting 3-6 months after HSCT, focuses on short-term immunogenicity while long-term immunogenicity is not well characterized. The current Dutch immunization schedule, which starts at 12 months post allo-HSCT, was developed as a result of concerns on the coverage of long-term immunogenicity in international guidelines. Read More

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November 2018

Travel-associated Legionnaires' disease: would changing cluster definition lead to the prevention of a larger number of cases?

Epidemiol Infect 2018 Dec 3:1-6. Epub 2018 Dec 3.

Biolinea Int.,Palma de Mallorca,Spain.

According to European Guidelines for Legionnaires' Disease prevention and control, travel-associated Legionnaires' disease (TALD) cases are managed differently if classified as sporadic or as part of a cluster and more stringent control measures are deployed after clusters are identified. In this study, we propose to modify the current cluster definition: 'two or more cases of Legionnaires' disease (LD) who stayed at, or visited, the same commercial accommodation site 2-10 days before onset of illness and whose onset is within the same 2-year period' with a new cluster definition, i.e. Read More

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December 2018

Tansition Metal-Based Prodrugs for Anticancer Drug Delivery.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa. Av. Rovisco Pais, 1049-001 Lisboa. Portugal.

Transition metal complexes, of which the platinum(II) cisplatin complex is an example, have been used in medicine to treat cancer for more than 40 years. Although many successes have been achieved, there are problems associated with the use of these drugs, such as side effects and drug resistance. Converting them into prodrugs, to make them more inert, so that they can travel to the tumour site unchanged and release the drug in its active form only there, is a strategy which is the subject of much research nowadays. Read More

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December 2018
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The Role of Community Pharmacists in Travel Health and Vaccination in Switzerland.

Pharmacy (Basel) 2018 Nov 29;6(4). Epub 2018 Nov 29.

Community Pharmacy Centre, Department of Ambulatory Care and Community Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.

This review presents the Swiss strategy initiated over the last several years to implement vaccination by community pharmacists. National health authorities aimed to integrate community pharmacists in the National Vaccination Strategy (NVS) in order to increase the vaccination rate in the Swiss population. To support this aim, universities and the Swiss Association of Pharmacists developed pre- and post-graduate education programmes on vaccination for pharmacists. Read More

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November 2018

Mind the gap: Building the psychological capital of travellers.

J Travel Med 2018 Dec 5. Epub 2018 Dec 5.

Spire Shawfair Park Hospital, Edinburgh, United Kingdom.

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December 2018

Sleep and breathing disturbances in patients with chronic obstructive pulmonary disease traveling to altitude: a randomized trial.

Sleep 2018 Dec 4. Epub 2018 Dec 4.

Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

Study Objectives: Patients with chronic obstructive pulmonary disease (COPD) have impaired pulmonary gas exchange near sea level. The purpose of the current study was to investigate whether exposure to hypobaric hypoxia during a stay at altitude affects nocturnal oxygen saturation, breathing pattern, and sleep in patients with moderate to severe COPD.

Methods: Thirty-two patients with COPD, median age 67 years, FEV1 59% predicted, PaO2 68 mmHg, living below 800 m, underwent polysomnography and questionnaire evaluations in Zurich (490 m), and in Swiss Alpine villages at 1650 and 2590 m, for two nights each, in random order. Read More

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December 2018
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Real-world treatment outcomes in multiple myeloma: Multicenter registry results from Finland 2009-2013.

PLoS One 2018 5;13(12):e0208507. Epub 2018 Dec 5.

Janssen Cilag AB, Solna, Sweden.

Outcomes for patients with multiple myeloma (MM) have improved with the advent of novel therapies, however, real-world evidence of outcomes in clinical practice is scarce. We conducted a multi-center registry study to build a reliable picture of treatment and patient outcomes in Finland. The aim of this study was also to understand any methodological challenges in assessing treatment outcomes using disease registry data. Read More

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December 2018
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Economic Analysis of a Three-Arm RCT Exploring the Delivery of Intensive, Prophylactic Swallowing Therapy to Patients with Head and Neck Cancer During (Chemo)Radiotherapy.

Dysphagia 2018 Dec 4. Epub 2018 Dec 4.

Radiation Oncology Department, Princess Alexandra Hospital, Metro South Hospital & Health Service, Brisbane, QLD, 4102, Australia.

Research advocates for the use of intensive, prophylactic swallowing therapy to help reduce the severity of dysphagia in patients receiving (chemo)radiotherapy ([C]RT) for head/neck cancer (HNC). Unfortunately, the intensity of this therapy, coupled with growing patient numbers and limited clinical resources, provides challenges to many international cancer facilities. Telepractice has been proposed as a potential method to provide patients with greater support in home-practice, whilst minimising burden to the health service. Read More

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December 2018
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Exploring changes in active travel uptake and cessation across the lifespan: Longitudinal evidence from the UK Household Longitudinal Survey.

Prev Med Rep 2019 Mar 15;13:57-61. Epub 2018 Nov 15.

Department of Social & Environmental Health Research, London School of Hygiene & Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, United Kingdom.

This study aims to explore changes in uptake and cessation of walking, cycling and public transport use across the lifespan in a representative sample of UK adults aged 16 and older. A longitudinal analysis of 11,559 individuals in waves two (2010-2012) and six (2014-2016) of the General Population Sample (GPS) of the UK Household Longitudinal Survey (UKHLS) was performed. The outcome variables were self-reported and categorised as changes to and from 1) walking or cycling and 2) public transport. Read More

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Roll-your-own cigarette use and smoking cessation behaviour: a cross-sectional population study in England.

BMJ Open 2018 Dec 4;8(12):e025370. Epub 2018 Dec 4.

Department of Behavioural Science and Health, University College London, London, UK.

Objectives: Roll-your-own (RYO) cigarettes have become popular in the UK and reduce the cost of smoking, potentially mitigating the impact of tax increases on quitting. We examined whether RYO cigarette use was associated with reduced motivation to quit smoking, incidence of quit attempts and quit success.

Design: Cross-sectional survey. Read More

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December 2018
1 Read