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Eur Oral Res 2018 Sep 1;52(3):157-161. Epub 2018 Sep 1.

Department of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.

Purpose: Present study was undertaken to evaluate and compare the salivary levels of tumour necrosis factor alpha (TNF-α) in subjects with RAS, traumatic ulcers (TUs) in the oral mucosa and in healthy controls.

Materials And Methods: Present study involved 90 participants of which 30 subjects were diagnosed with RAS, 30 subjects with TUs and 30 healthy controls grouped as group 1, group 2 and group 3 respectively. Unstimulated saliva was collected from the subjects through 'Spit Technique' and the estimation of TNF-α was done by enzyme linked immunosorbent assay. Read More

Arch Med Sci Atheroscler Dis 2018 15;3:e35-e40. Epub 2018 Feb 15.

Shanghai Xin Hua Hospital affiliated to the Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Introduction: Peripheral arterial disease (PAD) is a major risk factor of coronary artery disease and a major complication of atherosclerosis. Peripheral arterial disease can be diagnosed with simple and low cost techniques. There are major risk factors of PAD that have been studied for different countries. Read More

ACG Case Rep J 2018 5;5:e85. Epub 2018 Dec 5.

Bariatric Surgery Unit, General Surgery Department, Cairo University Hospital, Cairo, Egypt.

Bariatric surgery leaks remain a dreaded complication with ominous consequences. Fully covered stents have shown efficacy in the treatment of leaks; however, stent migration remains a major drawback. Ultra-large stents have shown reduced rates of migration and coapt better against the walls, but deep ulcers occur in almost all patients, as well as frequent severe intolerance, bleeding, and perforation. Read More

Eur J Cardiothorac Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Vascular Surgery, University Aortic Center of the Ludwig-Maximilian University Munich, Munich, Germany.

Objectives: Thoracic endovascular aortic repair (TEVAR) has emerged as a safe procedure in the treatment of a wide spectrum of descending thoracic aortic pathologies, with satisfactory results both in elective and urgent settings. We investigated the results of our elective, urgent and emergency TEVAR interventions.

Methods: A single-centre retrospective analysis of all consecutive patients undergoing TEVAR from 2010 to 2016 was performed. Read More

Front Neurol 2019 29;10:27. Epub 2019 Jan 29.

Department of Neurosurgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Spinal Cord Injury (SCI) is a major challenge in Neurotrauma research. Complex pathophysiological processes take place immediately after the injury and later on as the chronic injury develops. Moreover, SCI is usually accompanied by traumatic injuries because the most common modality of injury is road traffic accidents and falls. Read More

J Prosthet Dent 2019 Feb 26;121(2):225-228. Epub 2018 Oct 26.

Associate Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Tuberculosis (TB) of the oral cavity may be overlooked in the differential diagnosis of oral lesions and can be misdiagnosed and managed incorrectly. A 66-year-old man with complete dentures presented with a nonhealing mucosal ulcer in the upper lip. Despite the treatments performed by a local medical clinic, the ulcerative lesion on the denture-bearing area had not improved over 5 months. Read More

Ann Vasc Surg 2019 Jan 30. Epub 2019 Jan 30.

Division of Vascular Surgery, Harbor-UCLA Medical Center, Torrance, CA; Division of Vascular Surgery, Long Beach Memorial Heart & Vascular Institute, Long Beach, CA.

Introduction: Dynamic compliance (Cd) of the adult thoracic ascending and arch aorta has had limited evaluation in vivo in patients with aortic disease. This study evaluates aortic compliance using intravascular ultrasound (IVUS) across a range of thoracic aortic diseases.

Methods: Seventy-nine patients undergoing thoracic aortic endovascular procedures had Cd measurements of the ascending aorta proximal to the origin of the brachiocephalic trunk and distal to the origin of the left common carotid artery using IVUS prior to endograft deployment. Read More

Head Neck Pathol 2019 Jan 31. Epub 2019 Jan 31.

Department of Diagnostic and Biomedical Sciences, University of Texas at Houston Health Science Center School of Dentistry, Houston, TX, USA.

Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Read More

Zhonghua Yi Xue Za Zhi 2018 Dec;98(48):3936-3940

Intensive Care Unit, Tongzhou People's Hospital, Nantong 226300, China.

To investigate the effects of nasogastric tube (NGT) and percutaneous endoscopic gastrostomy (PEG) tube feeding on the susceptibility of pulmonary infection in long-term coma patients with stroke or traumatic brain injury. A total of 295 candidates who were in long-term coma after stroke or traumatic brain injury but without pulmonary infection and eligible for PEG catheterization were screened prospectively between January 2014 and February 2018. The patients were divided into PEG group (86 patients) and NGT group (209 patients) according to the choice of next-of-kin. Read More

Community Dent Health 2019 Jan 17. Epub 2019 Jan 17.

Dental student, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh. Saudi Arabia.

Objective: To assess the relationship between body mass index (BMI) and the sum of decayed, missing and filled teeth (DMFT), periodontal pockets, and oral soft tissue variations.

Basic Research Design: A systematic sample of 250 people attending King Abdulaziz Medical City was included. The study was conducted using questionnaires and clinical examinations. Read More

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):444

Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil.

Background: The oral wound healing is dependent of immune participation and the absence or augment of one specific immune profile can delayed wound healing.

Objectives: So, the objective of this study was t evaluate the wound healing of oral traumatic ulcer (OTU) in cheek mucosa of swiss, balb/c and c57bl6J mice.

Materials And Methods: A total of 144 mice (25-30g) were distributed in three groups: swiss ( = 48), balb/c ( = 48) and c57bl/6j ( = 48). Read More

Diabetes Metab Syndr 2019 Jan - Feb;13(1):228-234. Epub 2018 Aug 29.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03680, Ukraine; LCL "DIAPROF", Svitlycky Str., 35, Kyiv, 04123, Ukraine.

Wound healing in diabetes is frequently impaired and its treatment remains a challenge. The ability of topical application of cerium (Ce) dioxide nanoparticles (CNPs) to accelerate wound healing in an animal model provides a rationale to develop this technology for use in humans affected by traumatic injury, diabetes and burns. We first described a case report of successful topical treatment of neuropathic diabetic foot ulcers with novel gel containing CNPs. Read More

Oral Oncol 2019 Feb 26;89:155-156. Epub 2018 Dec 26.

Department of Oral Medicine, Dentistry College, Universidad Nacional de Córdoba, Argentina. Electronic address:

Medicine (Baltimore) 2018 Dec;97(51):e13803

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital.

Both diabetic peripheral neuropathy and peripheral arterial disease (PAD) cause foot ulcers and often result in non-traumatic amputations in patients with type 2 diabetes. This study aimed to evaluate the association between clinical variables, PAD, and subclinical diabetic small fiber peripheral neuropathy detected by abnormal thermal thresholds of the lower extremities in patients with type 2 diabetes.We investigated 725 consecutive patients with type 2 diabetes (male/female: 372/353; mean age, 67 ± 11 years) who did not have apparent cardiovascular disease (including coronary artery disease, arrhythmia, and stroke) and who underwent the quantitative sensory test for thermal (warm and cold) thresholds of the lower limbs and ankle-brachial index (ABI)/toe-brachial index (TBI) examinations in 2015. Read More

Adv Skin Wound Care 2019 Jan;32(1):19-25

At Brigham and Women's Hospital in Boston, Massachusetts, Yukun Liu, MD, was a Research Fellow at the time this manuscript was written; Adriana C. Panayi, MD, is a Research Fellow; Lauren R. Bayer, PA-C, is Clinical Director of the Wound Care Center; and Dennis P. Orgill MD, PhD is Director of the Wound Care Center, Department of Surgery, Brigham and Women's Hospital; and Professor of Surgery, Harvard Medical School. Acknowledgment: Dr Orgill is a consultant and/or receives research funding from Integra LifeSciences Corporation, the Musculoskeletal Research Foundation, Geistlich Corporation, Acell Corporation, and Professional Education and Research Incorporated. The authors have disclosed no other financial relationships related to this article. Submitted May 18, 2018; accepted June 29, 2018.

The occurrence of diabetic foot ulcers and venous leg ulcers is increasing because of aging population trends as well as increases in the number of people with diabetes and obesity. New technologies have been developed to treat these conditions, whereas other technologies previously designed for burns and traumatic wounds have been adapted. This article reviews the development of selected skin replacement technologies, particularly cellular and tissue-based products, highlighting their effectiveness on diabetic foot ulcers, venous leg ulcers, and burns. Read More

Int J Surg Case Rep 2018 22;53:468-470. Epub 2018 Nov 22.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Sygehusvej 10, 4000, Roskilde, Denmark.

Objective: Malignant transformation of chronic non-healing wounds is often overlooked. If a chronic wound fails to heal, or if there are changes in the characteristics of a wound, a biopsy should be performed.

Methods: This case is presented in line with SCARE guidelines. Read More

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Objective: The objective of this study was to evaluate the incidence, timing, and potential risk factors of late endograft migration after thoracic endovascular aortic repair (TEVAR).

Methods: A retrospective analysis was conducted of 123 patients receiving TEVAR for thoracic aortic aneurysms (TAAs), dissections, penetrating aortic ulcer, intramural hematoma, or traumatic transection between January 2005 and December 2015 with a minimum imaging-based follow-up of 6 months. Imaging analysis was performed by three independent readers. Read More

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

Arch Phys Med Rehabil 2018 Nov 23. Epub 2018 Nov 23.

College of Health Professions, Medical University of South Carolina, Charleston, SC.

Objective: The purpose of this study was to (1) categorize individuals into high, medium, and low utilizers of health care services over a 10-year period after the onset of spinal cord injury (SCI) and (2) identify the pattern of causes of hospitalizations and the characteristics associated with high utilization.

Design: Retrospective analysis of self-report assessment linked to administrative data.

Setting: Data were collected from participants living in and utilizing hospitals in the state of South Carolina. Read More

Arch Plast Surg 2018 Nov 15;45(6):564-571. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea.

Background: Chronic wounds occur due to failure of the normal healing process, associated with a lack of deposition of cellular components and a suitable microenvironment such as the extracellular matrix (ECM). Acellular dermal matrix (ADM) is viewed as an ECM substitute, and a paste-type ADM has recently been introduced. We hypothesized that CGPaste, an injectable paste-type ADM, could serve as a scaffold and promote wound healing. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Nov;32(11):1411-1416

Department of Traumatic Orthopedics, the Affiliated Hospital of Chengde Medical University, Chengde Hebei, 067000, P.R.China.

Objective: To investigate the difference in the effectiveness between proximal femoral nail anti-rotation (PFNA) and proximal femoral locking compression plate (PFLCP) for intertrochanteric fracture in elderly patients combined with hemiplegia due to cerebral infarction.

Methods: The clinical data of 67 cases of intertrochanteric femoral fractures combined with hemiplegia due to cerebral infarction between October 2013 and January 2017 were retrospectively analyzed. Among them, 32 cases were treated with PFNA internal fixation (PFNA group), and 35 cases were treated with PFLCP internal fixation (PFLCP group). Read More

Injury 2018 Nov;49 Suppl 3:S105-S109

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Introduction: Foot and ankle are prone to injuries and often require free flap for complex soft tissue reconstruction due to the insufficiency of local soft tissue. Lower limb reconstruction can be commonly compromised by venous insufficiency, and the elevation of the limb represents a critical component of the postoperative care. This study aims to explore the versatility of combining free soft tissue flap reconstruction for complex foot and ankle defect with a temporary Kickstands External Fixator (KEF) placement. Read More

Med Sci Monit 2018 Nov 2;24:7828-7840. Epub 2018 Nov 2.

Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND Marjolin ulcer (MU) is an aggressive cutaneous malignancy. Typically, MU occurs over a period of time in post-burn and/or post-traumatic lesions and scars. However, the pathogenesis of scar carcinogenesis and MU development remains to be elucidated. Read More

J Dermatol 2019 Jan 31;46(1):48-51. Epub 2018 Oct 31.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Chronic oral ulcers are induced by various causative factors. Biopsy from an active site around ulceration is critical for both the definitive diagnosis and proper treatment. We report two cases of chronic oral ulcers, circumorificial plasmacytosis (CP) and traumatic ulcerative granuloma with stromal eosinophilia (TUGSE). Read More

Ann Ital Chir 2018 Jun 12;7. Epub 2018 Jun 12.

Aim: Presentation and discussion of a case of heterotopic ossification of a vertical abdominal surgical scar.

Personal Observation: A recent trauma in an 70 year old patient, followed by a sudden internal hemorrhage because of a penetration in abdomen of a bone stump, originated from a fracture of a not known heterotopic ossification of an old median abdominal scar, of a laparotomy of many years earlier for perforated duodenal ulcer.

Results: An emergency surgery was mandatory DISCUSSION: Pathogenesis of heterotopic ossification, as rare metaplastic phenomenon outside of the normal bone tissue, still unknown and speculative. Read More

Curr Diabetes Rev 2018 Oct 16. Epub 2018 Oct 16.

Michigan Medicine, Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes. Domino's Farms (Lobby C, Suite 1300) 24 Frank Lloyd Wright Drive Ann Arbor, Michigan 48106. United States.

Aims/hypothesis: Diabetes foot complications remain very prevalent in US and worldwide, and a major risk for devastating amputations. We evaluated the impact of establishing a fully integrated and specialized Podiatry service into a large tertiary academic health system to implement structured and targeted preventative foot care on limb salvage rates.

Methods: Cross-sectional cohorts' data mining analysis of all encounters for diabetes and any foot complications between 2000-2005 and 2010-2015, preceding and after full implementation of podiatry service, respectively. Read More

J Biomater Appl 2018 Oct;33(4):553-565

1 Southwest Research Institute, Department of Pharmaceuticals and Bioengineering, San Antonio, TX, USA.

Chronic wounds complicated by diabetes are a significant clinical issue, and their occurrence is expected to continue to rise due to an increased prevalence of diabetes mellitus, especially type 2 diabetes. Diabetic wounds frequently lead to nonhealing ulcers, and often eventually result in limb amputation due to the high risk of infection of the chronic wound. Here, we present a tissue-engineered treatment that combines a novel electrochemically deposited collagen wound matrix and human adipose-derived stem cells. Read More

World Neurosurg 2019 Jan 9;121:e792-e797. Epub 2018 Oct 9.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Thoracic vertebral fracture repair after a traumatic injury can be associated with significant risk for postoperative complications. Surgical outcomes are further complicated by patient comorbidity, particularly diabetes mellitus. This study compared outcomes and complication rates for traumatic thoracic vertebral fracture repair in a matched sample of patients with diabetes and nondiabetic control subjects. Read More

EFORT Open Rev 2018 Sep 27;3(9):513-525. Epub 2018 Sep 27.

Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece.

The lifetime risk for diabetic patients to develop a diabetic foot ulcer (DFU) is 25%. In these patients, the risk of amputation is increased and the outcome deteriorates.More than 50% of non-traumatic lower-extremity amputations are related to DFU infections and 85% of all lower-extremity amputations in patients with diabetes are preceded by an ulcer; up to 70% of diabetic patients with a DFU-related amputation die within five years of their amputation. Read More

J Spinal Cord Med 2018 Oct 2:1-7. Epub 2018 Oct 2.

b Department of Trauma , Baylor University Medical Center , Dallas , Texas , USA.

Objective: The purpose was to describe the prevalence and characteristics of healthcare utilization among individuals with spinal cord injury (SCI) from a Level I trauma center.

Design: Retrospective data analysis utilizing a local acute trauma registry for initial hospitalization and merged with the Dallas-Fort Worth Hospital Council registry to obtain subsequent health care utilization in the first post-injury year.

Setting: Dallas, TX, USA. Read More

Ann Phys Rehabil Med 2018 Sep 28. Epub 2018 Sep 28.

Centre mutualiste neurologique Propara, 263, rue du Caducée, 34090 Montpellier, France. Electronic address:

Background: Flap surgery for deep pelvic pressure ulcers (PPUs) has been found effective, but the recurrence rate remains high and few risk factors have been identified.

Objective: We evaluated risk factors for PU recurrence after primary flap surgery in people with spinal cord injury (SCI).

Patients And Methods: This observational retrospective study based on medical charts included all individuals with SCI who underwent primary flap surgery for a PPU in the Hérault department in France between 2006 and 2014. Read More

Ann Ib Postgrad Med 2018 Jun;16(1):9-11

Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State, Nigeria.

Aim: This study aimed at describing the epidemiology and pattern of presentation of oral ulcerations among patients seen in Oral Medicine clinic of Obafemi Awolowo University Complex, Ile-Ife.

Methodology: This study was a retrospective cohort study of all cases that presented with oral ulcers in the oral medicine clinic between May 2015 and May 2017. The clinical diagnosis of oral ulcers was based on the WHO guidelines for oral mucosa diagnosis. Read More

Int J Biol Macromol 2019 Feb 15;122:1035-1045. Epub 2018 Sep 15.

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address:

The purpose of this research is to arouse people's cognition of the dual role of Bletilla striata polysaccharide (BSP)-a kind of biocompatible, biodegradable natural biological materials with myriad pharmacological activities. BSP was extracted and characterized firstly. The results indicated that BSP was composed of mannose and glucose. Read More

World J Emerg Med 2018 ;9(4):272-275

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.

Background: The purpose of this study is to assess the utility of ocular ultrasound B scan in the emergency at the first point of care for detecting posterior segment and orbital pathologies in cases of paediatric ocular emergencies.

Methods: A prospective observational study involving 122 paediatric patients presenting to eye emergency over a period of ninety days were assessed with ultrasonography for the posterior segment as well as orbital pathology whenever indicated. The ocular ultrasound was performed gently over closed eyelids. Read More

Int J Prosthodont 2018 Sep/Oct;31(5):481-484

Purpose: To investigate the effects of over-the-counter products on the healing of denture-induced ulcerations and patients' self-reported pain.

Materials And Methods: A total of 140 patients with acute denture-induced ulcerations were randomized into seven treatment groups: denture grinding (control); topical application of corn oil gel (placebo); triester glycerol oxide gel; D-panthenol gel; D-panthenol mouthwash; L-arginine mouthwash; and hyaluronic acid gel. Healing and self-reported pain were assessed after 1, 3, and 7 days of treatment. Read More

Oral Oncol 2018 Oct 30;85:101-102. Epub 2018 Aug 30.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Oxf Med Case Reports 2018 Aug 11;2018(8):omy044. Epub 2018 Aug 11.

Internal Medicine Department, Hurley Medical Center/Michigan State University, Flint, MI, USA.

Marjolin's ulcer is a rare and aggressive type of Squamous Cell Carcinoma (SCC) originating from previously chronic non-healing inflamed skin or trauma, and often after burns in up to 2% of cases. We are presenting a case of SCC secondary to a 30-year history of burn scar. Wound care and traumatic wound closure to prevent malignant degeneration is advisable and should be considered by medical providers. Read More

Rev Assoc Med Bras (1992) 2018 Apr;64(4):374-378

Universidade Anhembi Morumbi, São Paulo, SP, Brasil.

Objective: To evaluate the incidence, mortality and cost of non-traumatic abdominal emergencies treated in Brazilian emergency departments.

Methods: This paper used DataSus information from 2008 to 2016 (http://www.tabnet. Read More

J Spinal Cord Med 2018 Aug 21:1-9. Epub 2018 Aug 21.

a Department of Kinesiology and Community Health , College of Applied Health Sciences, University of Illinois at Urbana-Champaign , Illinois , USA.

Context/objective: To examine personal (athletic classification, age, sex, body mass index, duration of disability, tactile sensation of lower extremities) and wheelchair (kneeling plate angle) factors associated with increased pretibial skin pressures in elite wheelchair racers.

Design: Cross-sectional study.

Setting: University-based laboratory in Champaign, USA. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jul;43(7):779-783

Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment.
 Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed. Read More

BMJ Open 2018 Aug 10;8(8):e021556. Epub 2018 Aug 10.

Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.

Introduction: Corneal opacity is a leading cause of blindness worldwide. In resource-limited settings, untreated traumatic corneal abrasions may result in infection and ultimately, opacity. Although antimicrobial treatment of corneal ulcers may successfully cure infections, the scarring that accompanies the resolution of infection can still result in visual impairment. Read More

J Prosthet Dent 2019 Jan 7;121(1):76-82. Epub 2018 Aug 7.

Dean, Associate Professor, and Consultant, College of Dentistry, Aljouf University, Sakaka, Saudi Arabia. Electronic address:

Statement Of Problem: Management of denture-related traumatic ulcers using ozone may improve tissue healing and reduce patient pain and discomfort.

Purpose: The purpose of this clinical investigation was to assess the efficacy of ozone in the treatment of denture-related traumatic ulcers.

Material And Methods: Seventy-five participants (study group) with denture-related traumatic ulcers were evaluated in this blinded, controlled cohort observational investigation. Read More

Phytother Res 2018 Nov 8;32(11):2275-2281. Epub 2018 Aug 8.

Oral Medicine Department, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.

The effects of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, were assessed on oral wound healing in an in vivo model. Standardized ulcers were induced in 60 Wistar rats using a 5-mm biopsy punch on the midline of the ventral tongue. Animals received intraperitoneal injections of CBD at doses of 0 (control), 5, and 10 mg/kg daily. Read More

Med Hypotheses 2018 Sep 28;118:93-97. Epub 2018 Jun 28.

Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Objectives: To investigate whether percutaneous endoscopic gastrostomy (PEG) tube placement is associated with increased risk of gastric cancer.

Methods: We conducted a nationwide population-based retrospective study in Taiwan. Inpatient data from 1997 to 2010 were collected from Taiwan National Health Insurance Research Database. Read More

Br J Surg 2018 Oct 19;105(11):1487-1492. Epub 2018 Jul 19.

Department of Surgery, University of Catania, Catania, Italy.

Background: Ideal surgical treatment for acute duodenal injuries should offer a definitive treatment, with low morbidity and mortality. It should be simple and easily reproducible by acute care surgeons in an emergency. Duodenal injury, due to major perforated or bleeding peptic ulcers or iatrogenic/traumatic perforation, represents a surgical challenge, with high morbidity and mortality. Read More

Chin Med J (Engl) 2018 Jul;131(14):1658-1665

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Background: Infectious endophthalmitis is a severe ocular inflammation which can cause devastating visual loss. The aim of the study was to identify the demographic and clinical features of infectious endophthalmitis in Western China for better prophylaxis and treatment of this disease.

Methods: A. Read More

Rev Esp Cir Ortop Traumatol 2019 Jan - Feb;63(1):41-48. Epub 2018 Jul 3.

Servicio de Cirugía Ortopédica y Traumatología, Consorci Sanitari Integral, Barcelona, España.

Objective: We present a case series report of patients with Charcot foot treated by single-stage surgery with static circular fixation.

Material And Method: Retrospective review of 10 cases treated with static circular external fixation since 2016, with the following inclusion criteria: 1) Deformity with any of the following: ulcers, osteoporosis, osteomyelitis or instability 2) peripheral neuropathy, 3) failed orthopaedic treatment.

Exclusion Criteria: 1) peripheral vascular obstruction without revascularization, 2) inability to comply with treatment, 3) non-ambulatory patients, 4) medical contraindication for surgery. Read More

Hautarzt 2018 Aug;69(8):662-673

Klinik für Dermatologie, Venerologie und Allergologie, Venenzentrum der Dermatologischen und Gefäßchirurgischen Kliniken, Ruhr-Universität Bochum, Hiltroper Landwehr 11-13, 44805, Bochum, Deutschland.

Under the direction of the German Society of Phlebology (Deutsche Gesellschaft für Phlebologie) and in cooperation with other specialist associations, the S1 guideline on intermittent pneumatic compression (IPC) was adopted in January 2018. It replaces the previous guideline from March 2005. The aim of the guideline is to optimize the indication and therapeutic use of IPC in vascular diseases and edema. Read More

PLoS Negl Trop Dis 2018 06 25;12(6):e0006584. Epub 2018 Jun 25.

Department of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Neglected Tropical Diseases (NTDs) are a group of several communicable diseases prevalent in the tropical and subtropical areas. The co-endemicity of these diseases, the similarity of the clinical signs, and need to maximize limited financial and human resources have necessitated implementation of integrated approach. Our study aims to share the lessons of this integrated approach in the fight against Buruli ulcer (BU), leprosy and yaws in a rural district in Benin. Read More

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(3):81-87

Burdenko Neurosurgery Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.

One of the frequent consequences of severe traumatic brain injury is posttraumatic hydrocephalus that not only hampers the processes of consciousness recovery, rehabilitation, and social adaptation of patients but also is the cause of disability. Pathological processes underlying the clinical picture of posttraumatic hydrocephalus and the relationship between CSF circulation disorders and structural changes in the brain substance have not been adequately studied. Of particular importance are patients in the chronic vegetative or minimally conscious state, recovery from which is blocked by posttraumatic hydrocephalus. Read More