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J Maxillofac Oral Surg 2021 Jun 20;20(2):325-327. Epub 2020 Jun 20.

Department of Dentistry, AIIMS, Jodhpur, India.

Arq Gastroenterol 2021 Jan-Mar;58(1):32-38

Universidade do Extremo Sul Catarinense, Departamento de Medicina, Criciúma, SC, Brasil.

Background: Intravenous (IV) use of proton pump inhibitors (PPIs) is advised only in cases of suspected upper gastrointestinal bleeding (UGIB) or impossibility of receiving oral medication, although there has been a persistent practice of their inappropriate use in health institutions.

Objective: The purpose of our study was to measure the inappropriate use of IV PPIs in a high complexity hospital in Brazil and to estimate its costs.

Methods: Retrospective study of 333 patients who received IV omeprazole between July and December of 2018 in a high complexity hospital in Brazil. Read More

Plast Reconstr Surg Glob Open 2021 Mar 23;9(3):e3489. Epub 2021 Mar 23.

Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.

We report a case of traumatic lower extremity ulcers with lymphorrhea in a 37-year-old woman. She presented intractable ulcers without lymphedema for nearly 6 months after a traumatic injury. She was treated conservatively for 6 months at a referral hospital. Read More

Cureus 2021 Mar 20;13(3):e14014. Epub 2021 Mar 20.

Plastic Surgery, Hamad Medical Corporation, Doha, QAT.

Epithelioid sarcoma is a rare soft tissue sarcoma. It is a slow-growing neoplasm, which usually presents as a painless mass in the extremities and typically grows along deep dermal and subcutaneous planes. In contrast to other types of sarcoma, it has a strong tendency for nodal metastasis and local metastasis adjacent to the primary lesion within the affected limb. Read More

Niger Med J 2020 Nov-Dec;61(6):328-333. Epub 2020 Dec 19.

Department of General Surgery, Midnapore Medical College, West Midnapore, West Bengal, India.

Background: The purpose of this study is to estimate disease burden, clinical features, and outcome in the emergency surgical management of peptic perforation in a rural government tertiary care center where patients are socioeconomically very poor and also impacted by lack of good quality health-care facility.

Materials And Methods: The study had retrospectively analyzed 121 patients with peptic perforation who had undergone emergency laparotomy at Midnapore medical college, West Bengal, India, from June 2018 to December 2019. All patients >12 years were included in this study. Read More

Diabetes Res Clin Pract 2021 Apr 16;175:108821. Epub 2021 Apr 16.

Department of Endocrinology, Alfred Hospital, Melbourne 3004, Australia; Department of Medicine (Alfred), Monash University, Melbourne 3004, Australia. Electronic address:

Aims: To describe the demographics of patients with diabetic foot ulcers (DFU) and their impact on inpatient management. Secondary outcomes identified relationships of treatment modality with mortality, length of hospital admission, readmissions and post-admission care.

Methods: Retrospective cohort study including patients with DFU admitted to a hospital network in Melbourne, Australia from 2016 to 2018. Read More

J Low Genit Tract Dis 2021 Apr 14. Epub 2021 Apr 14.

Maternity and Gynaecology, John Hunter Hospital, Newcastle, New South Wales, Australia Faculty of Health and Medicine, University of Newcastle, New South Wales, Australia Private Practice, Essendon, Victoria, Australia Vulvar Disorders and Dermatology Clinic, Royal Hospital for Women, Parkville, Victoria, Australia Faculty of Medicine, Dentistry, and Health, University of Melbourne, Victoria, Australia Pathology NSW, Hunter New England, Newcastle, New South Wales, Australia.

Objective: The aim of the study was to identify whether erosive lichen sclerosus (LS) is a distinct clinicopathologic subtype.

Materials And Methods: The pathology database was searched for "erosion," "erosive," "ulcer," and "lichen sclerosus." Inclusion criteria were histopathologic diagnosis of LS and erosion or ulcer overlying a band of hyalinization and/or fibrosis. Read More

Afr J Lab Med 2021 23;10(1):1261. Epub 2021 Mar 23.

Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals, Ile-Ife, Nigeria.

Background: Infected diabetic foot ulcer (IDFU) is a public health issue and the leading cause of non-traumatic limb amputation. Very few published data on IDFU exist in most West African countries.

Objective: The study investigated the aetiology and antibacterial drug resistance burden of IDFU in tertiary hospitals in Osun state, Nigeria, between July 2016 and April 2017. Read More

Monaldi Arch Chest Dis 2021 Mar 9;91(2). Epub 2021 Mar 9.

Diagnostic Imaging Unit, "San Giuseppe e Melorio" Hospital, Santa Maria Capua Vetere, Italy.

Aortic diseases cover a large spectrum of conditions, such as aortic aneurysm and acute aortic syndromes (i.e., dissections, intramural hematoma, penetrating atherosclerotic ulcer, traumatic aortic injuries, and pseudoaneurysms), genetic diseases (e. Read More

Regen Med 2021 04 31;16(4):373-390. Epub 2021 Mar 31.

Department of Orthopedic Surgery & Biomedical Engineering, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI 49008, USA.

Numerous individuals suffer from impaired wound healing, such as chronic ulcers, severe burns and immune disorders, resulting in both public health and economic burdens. Skin is the first line of defense and the largest organ of the human body, however, an incomplete understanding of underlying cellular and molecular mechanisms of dermal repair leads to a lack of effective therapy for healing impaired wounds. There are strong clinical and social needs for improved therapeutic approaches to enhance endogenous tissue repair and regenerative capacity. Read More

SAGE Open Med Case Rep 2021 3;9:2050313X21997205. Epub 2021 Mar 3.

Clinical Research Division of the National Cancer Institute (INCA), Rio de Janeiro, Brazil.

Thermal burns of the oral cavity usually arise from ingestion of hot foods or beverages. A 38-year-old female patient presented with two painful ulcerative erythematous patches of the palate. The patient was consulted on the same day lesions appeared. Read More

Eur J Orthop Surg Traumatol 2021 Mar 9. Epub 2021 Mar 9.

Orthopedic and Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Purpose: Secondary displacement of traumatic ankle fractures with subsequent soft-tissue breakdown is a troublesome issue after inappropriate conservative treatment among non-compliant diabetic patients with severe peripheral neuropathy. This study was conducted to evaluate the results of a less-invasive arthrodesis procedure as an alternative to osteosynthesis in these complex scenarios.

Methods: A total of 46 diabetics, who underwent fluoroscopy-assisted trans-calcaneal retrograde nailing-based ankle arthrodesis between 2012 and 2018 for salvaging secondary-displaced diabetic ankle fractures in their insensate feet, were evaluated in this retrospective study. Read More

J Clin Orthop Trauma 2021 Feb 1;13:116-121. Epub 2020 Dec 1.

Department of Orthopaedics, Siddhartha Medical College, Vijayawada, India.

Introduction: Regular dressing of traumatic wounds is of paramount importance for healing. Phenytoin, an anticonvulsant, is thought to promote wound healing through multiple mechanisms, including fibroblast proliferation, granulation tissue formation, antibacterial activity, and pain alleviation.

Aim: To assess the effect of topical phenytoin on traumatic wound healing in terms of granulation tissue formation, pain alleviation, and time taken for wound healing. Read More

Biomedicines 2021 Feb 22;9(2). Epub 2021 Feb 22.

Department of Biomedical Engineering, Rutgers, State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.

Pressure ulcers (PUs) or sores are a secondary complication of diabetic neuropathy and traumatic spinal cord injury (SCI). PUs tend to occur in soft tissues located around bony prominences and may heal slowly or not at all. A common mechanism underlying impaired healing of PUs may be dysfunction of the local neurovascular system including deficiency of essential neuropeptides, such as substance P (SP). Read More

Radiographics 2021 Mar-Apr;41(2):425-446

From the Department of Radiology, Enloe Medical Center, 1531 Esplanade, Chico, CA 95926 (H.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (L.M., D.F.); and Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada (A.S.C.).

Acute aortic dissection is the prototype of acute aortic syndromes (AASs), which include intramural hematoma, limited intimal tear, penetrating atherosclerotic ulcer, traumatic or iatrogenic aortic dissection, and leaking or ruptured aortic aneurysm. The manifestation is usually sudden and catastrophic with acutely severe tearing chest or back pain. However, clinical symptoms do not allow distinction between AAS types and other acute pathologic conditions. Read More

Int J Low Extrem Wounds 2021 Feb 24:1534734621997283. Epub 2021 Feb 24.

Istanbul University-Cerrahpasa, Istanbul, Turkey.

Maggot debridement therapy (MDT) has been used for years in the treatment of chronic wounds and necrotic tissues. We report a case of subtotally amputated third toe that was treated with MDT after reattachment and developing complete necrosis. The necrotic toe was replaced with viable tissue and the wound healed completely after 2 weeks of MDT application. Read More

PLoS Negl Trop Dis 2021 Feb 16;15(2):e0009180. Epub 2021 Feb 16.

Centre Pasteur du Cameroun, Yaounde, Cameroon.

Outbreaks of yaws-like ulcerative skin lesions in children are frequently reported in tropical and sub-tropical countries. The origin of these lesions might be primarily traumatic or infectious; in the latter case, Treponema pallidum subspecies pertenue, the yaws agent, and Haemophilus ducreyi, the agent of chancroid, are two of the pathogens commonly associated with the aetiology of skin ulcers. In this work, we investigated the presence of T. Read More

Plast Reconstr Surg Glob Open 2021 Jan 26;9(1):e3376. Epub 2021 Jan 26.

Faculty of Medicine, Department of Hand Surgery, Plastic Surgery and Burns, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

The reconstruction of complex tissue defects in the lumbar and gluteal areas is a surgical challenge. The use of freestyle perforator-based flaps has gained popularity in the reconstruction of these defects due to several advantages: versatility, minimal donor-site morbidity, and tension-free closure. The present study reports the outcome of using a dual coverage of lumbar and gluteal defects with a gluteus maximus rotation flap as a deep layer and a freestyle propeller perforator-based flap as a superficial layer. Read More

Case Rep Pathol 2021 29;2021:8819560. Epub 2021 Jan 29.

Department of Diagnostic Pathology, Shimada Municipal Hospital, Shimada, Shizuoka, Japan.

A mildly diabetic 58-year-old male had traumatic ulceration on the left popliteal fossa, and the lesion progressed to a painful 6 cm deep ulcer. After surgical debridement and skin grafting, ulceration recurred. Pyoderma gangrenosum was clinically diagnosed after the first biopsy, indicating a noninfective ulcer. Read More

Vasa 2021 Apr 9;50(3):186-192. Epub 2021 Feb 9.

Department of Interventional Angiology, University Hospital Leipzig, Germany.

: Our aim was to determine the rate of ischemic stroke following thoracic endovascular aortic repair (TEVAR) after reducing gas volume released during stentgraft deployment by de-airing of thoracic stentgrafts with high-volume of 0.9% heparinized saline solution. : A single center retrospective analysis of all consecutive patients undergoing TEVAR from 2014 to 2019 was performed. Read More

Top Spinal Cord Inj Rehabil 2020 20;26(4):283-289. Epub 2021 Jan 20.

College of Health Professions, Medical University of South Carolina, Charleston, South Carolina.

Background: Secondary health conditions (SHC) are physical and mental health conditions that are causally related to disabilities. Studies have found that SHC increase risk of negative health outcomes among people with traumatic spinal cord injury (TSCI). However, little has been done to assess the association of SHC with the risk of chronic health conditions (CHC) after TSCI. Read More

BMC Surg 2021 Jan 12;21(1):34. Epub 2021 Jan 12.

Department of General Surgery, Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Tanzania.

Background: Diabetic foot ulcers complications are the major cause of non-traumatic major limb amputation. We aimed at assessing the clinical profiles of diabetic foot ulcer patients undergoing major limb amputation in the Surgical Department at Kilimanjaro Christian Medical Centre (KCMC), a tertiary care hospital in North-eastern Tanzania.

Methods: A cross-sectional hospital-based study was conducted from September 2018 through March 2019. Read More

J Endovasc Ther 2021 Apr 13;28(2):323-331. Epub 2021 Jan 13.

German Aortic Center Hamburg, Department of Vascular Medicine, University Heart & Vascular Center, Hamburg, Germany.

Cardiovascular societies have developed recommendations regarding the management of thoracic aortic diseases. While improvements in treatment have been observed during the past decade in regard to patient selection, thoracic endovascular aortic repair (TEVAR) and associated techniques, and high-volume centralization, the broad expansion of TEVAR has raised considerations about its indications, appropriateness, limitations, and application. The aim of this systematic review was to assess the similarities and differences among current cardiovascular societies' guidelines for the management of thoracic aortic diseases. Read More

Malays Orthop J 2020 Nov;14(3):82-89

Department of Orthopaedic and Traumatology, Centre Hospitalier Lyon-Sud, Pierre-Benite, France.

Introduction: Diabetic foot ulcer is the main aetiology for non-traumatic amputation, which is a major public health care concern. A multidisciplinary approach in the management of this pathology has been shown to improve the surgical outcome. However, there are little data available on the tools we can use to pursue this multidisciplinary approach. Read More

Urol Case Rep 2021 Mar 7;35:101524. Epub 2020 Dec 7.

Department of Urology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Biliary fistulas are most commonly caused by cholelithiasis. Other causes include malignancies and peptic ulcer disease. A biliary fistula caused by a penetrating trauma is a rare entity, and a post-traumatic biliary fistula to the renal collecting system is extremely uncommon. Read More

Heliyon 2020 Nov 23;6(11):e05552. Epub 2020 Nov 23.

Department of Adult Health Nursing, School of Health Science, College of Medicine and Health Science, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia.

A diabetes foot ulcer is the commonest non-traumatic reason for the amputation of the lower extremities. All adults with diabetes should undergo comprehensive foot evaluation at least annually, but for high-risk individuals with diabetes more frequently by a health care provider and daily by the people themselves. Nurses' knowledge and attitude are fundamental to conduct a diabetes foot risk assessment and provide foot care for known diabetes person. Read More

Med Hypotheses 2020 Nov 26;144:110217. Epub 2020 Aug 26.

Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina.

Several clinical and histological features, usually associated with chronic inflammation could complexify the diagnosis of oral epithelial dysplasia (OED). These changes in response to inflammatory stimuli, or re-epithelialization events, are described as reactive epithelial atypia or dysplasia (REA/D). Within a REA/D scenario (for example in the edges of chronic traumatic ulcers), the diagnosis of OED could be challenging for oral pathologists due to an unfeasibility to accurate the true nature of that changes. Read More

Zhonghua Wai Ke Za Zhi 2020 Dec;58(12):929-935

Department of Cardiothoracic Surgery, General Hospital of Eastern Theater Command, Nanjing 210002, China.

To examine the clinical treatment methods and short- and mid-term results of traumatic aortic injury (TAI). The clinical data of 30 patients suffering from TAI who were admitted to Department of Cardiothoracic Surgery, General Hospital of Eastern Theater Command from January 2010 to December 2018 were summarized and analyzed retrospectively. All patients were diagnosed as TAI by aortic CT angiography. Read More

Front Surg 2020 9;7:573901. Epub 2020 Nov 9.

Department of Surgery, Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Gastroduodenal perforation may be spontaneous or traumatic and the majority of spontaneous perforation is due to peptic ulcer disease. Improved medical management of peptic ulceration has reduced the incidence of perforation, but still remains a common cause of peritonitis. The classic sub-diaphragmatic air on chest x-ray may be absent and computed tomography scan is a more sensitive investigation in the stable patient. Read More