765 results match your criteria Traumatic Peripheral Nerve Lesions


[Peripheral Nerve Imaging - from a Neurological Perspective for Surgeons].

Zentralbl Chir 2020 Jul 2. Epub 2020 Jul 2.

Klinik für Neurologie, Städtisches Klinikum Dessau, Deutschland.

Nerve ultrasound is a fairly new non-invasive method to visualise peripheral nerves and to detect peripheral nerve lesions. This technique can depict nerve compression syndromes and their aetiologies as well as fascicular torsions. It is also suitable for sonographically guided nerve interventions and for intraoperative navigation. Read More

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http://dx.doi.org/10.1055/a-1189-3627DOI Listing

Enhanced MR neurography of the lumbosacral plexus with robust vascular suppression and improved delineation of its small branches.

Eur J Radiol 2020 Jun 11;129:109128. Epub 2020 Jun 11.

Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, 200030, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, 200030, People's Republic of China. Electronic address:

Purpose: To evaluate whether gadolinium enhanced 3D SPACE STIR sequence technique increases the visualization of the lumbosacral plexus (LSP) and its small branches.

Methods: A retrospective study was performed on 24 patients who had underwent 3D SPACE STIR sequences scan with and without the administration of gadolinium contrast. In this study, we focused on the healthy sides of the LSP and its branches in each patient. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109128DOI Listing

Facial palsy caused by an intrameatal metastatic disease - Reconstruction with an autologous sural nerve graft.

Injury 2020 May 16. Epub 2020 May 16.

School of Medicine, European University Cyprus, Nicosia, Cyprus.

Dysfunction of the facial nerve is frequently attributed to inflammation, followed by traumatic injury. Knowledge of the complex anatomical course of the facial nerve is critical to localize the site of pathology and for successful management. The multiplicity of etiologies and its complex anatomy often make facial paralysis a diagnostic challenge. Read More

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http://dx.doi.org/10.1016/j.injury.2020.03.048DOI Listing

Reduced inflammatory response and accelerated functional recovery following sciatic nerve crush lesion in CXCR3-deficient mice.

Neuroreport 2020 Jun;31(9):672-677

Department of Neurology.

Despite the regenerative capacity of the peripheral nerve system (PNS), functional recovery after mechanical nerve trauma is often incomplete, resulting in motor, sensory, and autonomic deficits. The elucidation of key molecules involved in trauma-induced Wallerian degeneration and the ensuing regeneration processes is a prerequisite for the development of disease modifying drugs. The chemokine (C-X-C motif) receptor 3 (CXCR3) has been implicated in the recruitment of macrophages, the major immune cell population during the process of Wallerian degeneration. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001468DOI Listing

Jammed ulnar nerve after distal radius fracture: A case report.

JPRAS Open 2020 Jun 18;24:20-24. Epub 2020 Mar 18.

Hand and Reconstructive Microsurgery Unit, Azienda Ospedaliero-Universitaria Careggi, Largo Palagi 1, Florence, Italy.

Background: Ulnar nerve lesions represent a rare complication of wrist fracture. The present manuscript describes the case of a particular traumatic mechanism in which the nerve resulted crushed between radial fracture fragments.

Case Presentation: A 47-year-old man suffered a subtotal lesion of the ulnar nerve following an open displaced distal radius fracture. Read More

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http://dx.doi.org/10.1016/j.jpra.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136588PMC

Post-amputation neuroma of radial nerve in a patient with ephitelioid sarcoma: case report and literature review.

Acta Biomed 2020 03 19;91(1):122-127. Epub 2020 Mar 19.

Radiology Department, National Cancer Institute Pascale Foundation, via M. Semmola 53, I-80131Naples Italy.

Neuroma, also known as traumatic neuroma or amputation neuroma or stump neuroma, is a focal non neoplastic area of proliferative hyperplastic reaction secondary to peripheral nerve damage that commonly occurs after a focal trauma (acute or chronic) or surgery, such as amputation or partial transection. Neuromas are more commonly located in the lower limbs, followed by head and neck; other extremely rare sites include the ulnar nerve followed by the radial nerve and the brachial plexus. A radiologic plan is necessary to recognize soft tissue lesions with a neural origin and whether they are a true tumor or a pseudotumor such as a neuroma, fibrolipoma, or peripheral nerve sheath ganglion. Read More

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http://dx.doi.org/10.23750/abm.v91i1.8510DOI Listing

Contribution of ultrasonography in evaluating traumatic lesions of the peripheral nerves.

Neurophysiol Clin 2020 Apr 20;50(2):93-101. Epub 2020 Feb 20.

Division of Neurology, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Zaloška cesta 2, SI-1525 Ljubljana, Slovenia. Electronic address:

Objective: To assess the indications for and utility of diagnostic ultrasonography (US) in a series of consecutive patients with suspected traumatic peripheral nerve lesions (TPNL).

Methods: We retrospectively reviewed the electronic medical records of consecutive patients referred from February 2013 to May 2018 to our US laboratory. All included patients were examined using standard US equipment, with a 4-13MHz linear array transducer. Read More

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http://dx.doi.org/10.1016/j.neucli.2020.01.007DOI Listing

[Neuromuscular complications of fractures of the extremities, part 2 : Nerve injuries and iatrogenic damage].

Unfallchirurg 2020 Mar;123(3):225-237

Unfallchirurgische Abteilung, Landeskrankenhaus Salzburg, Paracelsus Medizinische Universität, Salzburg, Österreich.

Lesions of peripheral nerves substantially influence the long-term prognosis and functional outcome. Approximately 70% of peripheral nerval lesions are associated with vascular injuries and occur more frequently with certain fractures and osteosynthesis types. The prognosis and treatment depend on the severity of the injury and the presence of axonal lesions, in particular, determines the further procedure. Read More

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http://dx.doi.org/10.1007/s00113-020-00768-9DOI Listing

Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association?

Eur J Ophthalmol 2020 Feb 16:1120672120906999. Epub 2020 Feb 16.

Laboratorio di Genetica Medica, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy.

Purpose: We investigated the molecular causes of an unusual pigmented and ulcerated iris lesion detected in a patient diagnosed with neurofibromatosis type 1 (NF1).

Case Report: A 52-year-old man was referred to our clinic with a non-traumatic ulcer in his left eye. Hyphema reabsorption disclosed a pigmented iris mass, thus ultrasound biomicroscopy and anterior segment fluorescein angiography were performed to investigate for the presence of a malignant lesion. Read More

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http://dx.doi.org/10.1177/1120672120906999DOI Listing
February 2020

Regeneration of Denervated Skeletal Muscles - Brunelli's CNS-PNS Paradigm.

J Med Life 2019 Oct-Dec;12(4):342-353

Department of Neurology, University Medical Center Schleswig-Holstein, Lübeck, Germany.

The restoration of voluntary muscle activity in posttraumatic paraplegia in both animal experiments and other clinical applications requires reproducibility of a technically-demanding microsurgical procedure, limited by physicians' understanding of Brunelli's spinal cord grafting paradigm. The insufficient clinical investigation of the long-term benefits of the CNS-PNS graft application warrants additional inquiry. The objective of this study is to explore the potential benefits of the first replicated, graft-induced neuroregeneration of denervated skeletal muscle regarding long-term clinical outcomes and to investigate the effect of Cerebrolysin on neuromodulation. Read More

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http://dx.doi.org/10.25122/jml-2019-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993288PMC

Ultrasonography: the third eye of hand surgeons.

Authors:
Esther Vögelin

J Hand Surg Eur Vol 2020 Mar 19;45(3):219-225. Epub 2020 Jan 19.

Department of Plastic and Hand Surgery, University of Bern, Inselspital, Bern, Switzerland.

High-resolution ultrasonography is an important tool used for the diagnosis and management of inflammatory arthritis of the hand and wrist. This imaging modality has also proven its utility in the evaluation of traumatic lesions of tendons, nerves, annular pulleys, ligaments, and carpal and digital injuries and for detecting foreign bodies and causes of joint locking. One of the great advantages is the possibility of getting an internal image of the involved anatomical structure in axial, coronal, and transversal planes, as well as the option for observing dynamic changes during motion. Read More

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http://dx.doi.org/10.1177/1753193419898155DOI Listing

[Organisation of peripheral nerve surgery in Denmark].

Ugeskr Laeger 2019 Dec;181(51)

This review summarises the current knowledge of peripheral nerve surgery (PNS) in Denmark, which comprises the surgery of traumatic nerve lesions, entrapment syndromes, nerve tumours, and biopsies. Although the Danish Health Authority generally works towards a centralisation of PNS, it is actually performed at a widespread number of hospitals, of which some perform a very low number of procedures per year. International standards are highly specialised centres with subspecialists of PNS, high caseload, and integrated rehabilitation facilities. Read More

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December 2019

Outcomes of Reconstructive Surgery in Traumatic Brachial Plexus Injury with Concomitant Vascular Injury.

World Neurosurg 2020 Mar 16;135:e350-e357. Epub 2019 Dec 16.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Objective: To investigate functional outcome from reconstructive surgery in adult traumatic brachial plexus injury (AT-BPI) with associated vascular lesions.

Methods: A retrospective review was performed of 325 patients with AT-BPI who underwent reconstructive surgery between 2001 and 2012. Patients with (vascular group) and without (control group) vascular injuries were identified by review of medical documentation. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.166DOI Listing

Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy.

Cells 2019 10 30;8(11). Epub 2019 Oct 30.

Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB) & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, E-08193 Barcelona, Spain.

Complete restoring of functional connectivity between neurons or target tissue after traumatic lesions is still an unmet medical need. Using models of nerve axotomy and compression, we investigated the effect of autophagy induction by genetic and pharmacological manipulation on motor nerve regeneration. ATG5 or NAD-dependent deacetylase sirtuin-1 (SIRT1) overexpression on spinal motoneurons stimulates mTOR-independent autophagy and facilitates a growth-competent state improving motor axonal regeneration with better electromyographic records after nerve transection and suture. Read More

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http://dx.doi.org/10.3390/cells8111354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912449PMC
October 2019

[Traumatic peripheral nerve lesions : Diagnosis and treatment].

Chirurg 2019 Nov;90(11):941-954

Sektion "Periphere Nervenchirurgie", Neurochirurgische Klinik der Universität Ulm am Bezirkskrankenhaus Günzburg, Ludwig-Heilmeyer-Str. 2, 89312, Günzburg, Deutschland.

Traumatic peripheral nerve lesions affect patients of all age groups. They are associated with functional deficits that have severe consequences for affected patients and prolonged or permanent inability to work has socioeconomic relevance. In order to improve prognoses and achieve the best possible outcome an early diagnosis and competent knowledge of the correct approach and treatment strategies are essential. Read More

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http://dx.doi.org/10.1007/s00104-019-01044-2DOI Listing
November 2019

F-FDG uptake in denervated muscles of patients with peripheral nerve injury.

Ann Clin Transl Neurol 2019 11 6;6(11):2175-2185. Epub 2019 Oct 6.

Department of Rehabilitation Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea.

Objective: We aimed to investigate the clinical significance of increased uptake in F-fluorodeoxyglucose positron emission tomography in patients with peripheral nerve lesions.

Methods: We selected patients with unilateral peripheral nerve lesions confirmed with electromyography who had undergone F-fluorodeoxyglucose positron emission tomography covering the lesions. In the denervated muscles and their contralateral corresponding pairs, a mean (SUVmean) and maximum standardized uptake value (SUVmax) were obtained from F-fluorodeoxyglucose positron emission tomography images. Read More

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http://dx.doi.org/10.1002/acn3.50899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856607PMC
November 2019

William Barnett Warrington (1869-1919).

Eur Neurol 2019 1;81(5-6):323-326. Epub 2019 Oct 1.

Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom,

William Barnett Warrington (1869-1919) was a physician and physiologist working in Liverpool, United Kingdom, at the end of the 19th and beginning of the 20th centuries. His training included periods at the National Hospital for the Paralysed and Epileptic, Queen Square, London, and in the Liverpool laboratory of Charles Scott Sherrington. He investigated structural alterations in nerve cells following various nerve lesions and helped to develop laboratory facilities to support clinical practice through the Pathological Diagnosis Society of Liverpool. Read More

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http://dx.doi.org/10.1159/000503102DOI Listing
October 2019
1 Read

Animal models used to study direct peripheral nerve repair: a systematic review.

Neural Regen Res 2020 Mar;15(3):491-502

Department of Microsurgery, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.

Objective: Peripheral nerve repair is required after traumatic injury. This common condition represents a major public health problem worldwide. Recovery after nerve repair depends on several factors, including the severity of the injury, the nerve involved, and the surgeon's technical skills. Read More

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http://dx.doi.org/10.4103/1673-5374.266068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921335PMC
March 2020
1 Read

Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration.

Neural Regen Res 2020 Mar;15(3):373-381

Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden. Although peripheral nervous system owns a higher regenerative capacity than does central nervous system, mostly depending on Schwann cells intervention in injury repair, several factors determine the extent of functional outcome after healing. Based on the injury type, different therapeutic approaches have been investigated so far. Read More

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http://dx.doi.org/10.4103/1673-5374.266043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921350PMC
March 2020
1 Read
0.234 Impact Factor

MANAGEMENT OF BRACHIAL PLEXUS MISSILE INJURIES.

Acta Clin Croat 2018 Sep;57(3):487-496

1Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Department of Peripheral Nerve Surgery, Functional Neurosurgery and Pain Management Surgery, Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia; 3Section for Neurosurgery, Department of Surgery, Ćuprija General Hospital, Ćuprija, Serbia; 4Department of Neurosurgery, Military Medical Academy, Belgrade, Serbia; 5Department of Neurosurgery, Kragujevac Clinical Center, Kragujevac, Serbia; 6Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 7Neuroradiology Department, Center for Radiology and MRI, Clinical Center of Serbia, Belgrade, Serbia; 8Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 9University of Applied Health Sciences.

- Missile injuries are among the most devastating injuries in general traumatology. Traumatic brachial plexus injuries are the most difficult injuries in peripheral nerve surgery, and most complicated to be surgically treated. Nevertheless, missile wounding is the second most common mechanism of brachial plexus injury. Read More

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http://dx.doi.org/10.20471/acc.2018.57.03.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536276PMC
September 2018
25 Reads

Antiapoptotic Effect of Granulocyte-Colony Stimulating Factor After Peripheral Nerve Trauma.

World Neurosurg 2019 Sep 11;129:e6-e15. Epub 2019 Apr 11.

Department of Neurosurgery, Saarland University Medical Center, Homburg-Saar, Germany. Electronic address:

Background: Granulocyte-colony stimulating factor (G-CSF) has been observed to have direct protective effects on neurons after stroke in experimental models and in humans. In the present study, the antiapoptotic effects of G-CSF on spinal α-motoneurons after inducement of peripheral sciatic nerve lesions were evaluated in a rat model.

Methods: Of 48 rats, 24 were treated with G-CSF and 24 were treated with glucose 5% solution (control group). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193105
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http://dx.doi.org/10.1016/j.wneu.2019.04.059DOI Listing
September 2019
11 Reads

4-Aminopyridine as a Single Agent Diagnostic and Treatment for Severe Nerve Crush Injury.

Mil Med 2019 03;184(Suppl 1):379-385

Department of Orthopaedics, University of Rochester, 601 Elmwood Ave, Rochester, NY.

Background: Traumatic peripheral nerve injury (TPI) is a major medical problem without effective treatment options. There is no way to diagnose or treat an incomplete injury and delays contribute to morbidity. We examined 4-aminopyridine (4-AP), a potassium-channel blocker as a possible treatment for TPI. Read More

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https://academic.oup.com/milmed/article/184/Supplement_1/379
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http://dx.doi.org/10.1093/milmed/usy399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433095PMC
March 2019
6 Reads

Traumatic brachial plexus injury: a study of 510 surgical cases from multicenter services in Guangxi, China.

Acta Neurochir (Wien) 2019 05 15;161(5):899-906. Epub 2019 Mar 15.

Department of Orthopedic Trauma and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic of China.

Background: Traumatic brachial plexus injuries are severe lesions, and the incidence of these injuries has been increasing in recent years.

Methods: The clinical data of 510 operated patients with brachial plexus injury recruited from 74 hospitals in Guangxi from 2004 to 2016 were retrospectively studied.

Results: Our study included 447 males and 63 females, with an average age of 29. Read More

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http://dx.doi.org/10.1007/s00701-019-03871-yDOI Listing
May 2019
12 Reads

A case series of penetrating spinal trauma: comparisons to blunt trauma, surgical indications, and outcomes.

Neurosurg Focus 2019 03;46(3):E4

1Department of Neurosurgery and.

OBJECTIVEWhile blunt spinal trauma accounts for the majority of spine trauma, penetrating injuries affect a substantial number of patients. The goal of this study was to examine the epidemiology of penetrating spine injuries compared with blunt injuries and review the operative interventions and outcomes in the penetrating spine injury group.METHODSThe prospectively maintained trauma database was queried for spinal fractures from 2012 to 2018. Read More

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http://dx.doi.org/10.3171/2018.12.FOCUS18577DOI Listing
March 2019
34 Reads

Functional MR Neurography in Evaluation of Peripheral Nerve Trauma and Postsurgical Assessment.

Radiographics 2019 Mar-Apr;39(2):427-446. Epub 2019 Feb 8.

From the MRI Section, Department of Radiology, SERCOSA, Health Time, Carmelo Torres 2, 23007 Jaén, Spain (T.M.N., A.L.); Peripheral Nerve and Plexus Department, Centro Rossi, Buenos Aires, Argentina (R.B.); MRI Section, Department of Radiology, DADISA, Health Time, Cádiz, Spain (M.G.C.); Peripheral Nerve and Plexus Surgery Unit, Department of Neurosurgery, University of Buenos Aires School of Medicine, Buenos Aires, Argentina (M.S.); Department of Radiology, NYU School of Medicine, New York, NY (J.T.B.); and Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio (A.L.).

Evaluation of traumatic peripheral nerve injuries has classically been based on clinical and electrophysiologic criteria. US and MRI have been widely used for morphologic assessment of nerve injury sites and concomitant lesions. In the past few years, morphologic MR neurography has significantly increased its clinical applications on the basis of three-dimensional or two-dimensional images with and without fat-suppression techniques. Read More

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http://dx.doi.org/10.1148/rg.2019180112DOI Listing
March 2020
6 Reads

Painful Traumatic Neuromas in Subcutaneous Fat: Visibility and Morphologic Features With Ultrasound.

J Ultrasound Med 2019 Sep 28;38(9):2457-2467. Epub 2019 Jan 28.

Department of Medical Imaging, Rennes University Hospitals, Sud Hospital, Rennes, France.

Objectives: Subcutaneous neuromas usually result from trauma and may lead to dissatisfaction in patients with a trigger point, loss of sensitivity in the relevant territory of innervation, and spontaneous neuropathic pain. Confirming clinically suspected cases of neuroma may prove difficult. The objective of this study was to evaluate the visibility and morphologic features of traumatic subcutaneous neuromas of the limbs with ultrasound (US). Read More

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http://dx.doi.org/10.1002/jum.14944DOI Listing
September 2019
5 Reads

The Extreme Lateral Approach to the Craniovertebral Junction: An Anatomical Study.

Acta Neurochir Suppl 2019;125:175-178

Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy.

Background: The extreme lateral approach is a direct lateral approach which allows a good control of the entire length of the vertebral artery (VA), the jugular foramen, the lowest cranial nerves, and the jugular-sigmoid complex. Herein we try to exploit the variants of the approach and we identify indications, advantages, and disadvantages.

Methods: All phases of the study were conducted at the Institute of Public Health Section of Legal Medicine and Insurance of the University. Read More

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http://dx.doi.org/10.1007/978-3-319-62515-7_26DOI Listing
August 2019
4 Reads

Navigation-assisted, endonasal, endoscopic optic nerve decompression for the treatment of nontraumatic optic neuropathy.

J Craniomaxillofac Surg 2019 Feb 13;47(2):328-333. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. Electronic address:

Background: Many authors have reported on therapeutic strategies for traumatic optic neuropathy and their experience with endonasal endoscopic optic nerve decompression for traumatic optic neuropathy. However, to our knowledge, few have described the therapeutic strategies for nontraumatic optic neuropathy and navigation-assisted endoscopic optic nerve decompression as a treatment for nontraumatic, compressive optic neuropathy. The aim of this study was to examine the advantages in treating nontraumatic optic neuropathy with the minimally invasive, image-guided, navigation-assisted, endonasal endoscopic optic nerve decompression. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.12.009DOI Listing
February 2019
16 Reads

Histopathological changes in major amputations due to diabetic foot - a review.

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

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December 2018
19 Reads

Delayed Myelopathy in Patients with Traumatic Preganglionic Brachial Plexus Avulsion Injuries.

World Neurosurg 2019 Feb 22;122:e1562-e1569. Epub 2018 Nov 22.

Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Cervical and upper thoracic nerve root avulsions are preganglionic lesions that occur after extreme traction of the brachial plexus. The tearing of the roots from the spinal cord pia leads, not only to immediate and permanent deficits, but also to delayed neurologic complications. Symptomatic myelopathy can present in a late fashion owing to chronic sequelae from the inciting traumatic event. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.102DOI Listing
February 2019
69 Reads

Is initial optic nerve sheath diameter prognostic of specific head injury in emergency departments?

J Natl Med Assoc 2019 Apr 8;111(2):210-217. Epub 2018 Nov 8.

Ankara Numune Education and Research Hospital; Department of Neurosurgery, Ankara, Turkey.

Background: Emergency departments (EDs) are typically the first medical contact for patients with traumatic brain injury (TBI) and early diagnosis and treatment of intracranial pressure (ICP) in patients with neurotrauma primarily falls under the liability of emergency doctors. Monitoring ICP with optic nerve sheath diameter (ONSD) via tools has gained popularity among emergency service doctors. In this study, we aimed to evaluate the predictive value of ONSD for specific head injury on initial cranial tomography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00279684183020
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http://dx.doi.org/10.1016/j.jnma.2018.10.009DOI Listing
April 2019
32 Reads

Study of Radial Nerve Injury Caused By Gunshot Wounds and Explosive Injuries among Iraqi Soldiers.

Open Access Maced J Med Sci 2018 Sep 21;6(9):1622-1626. Epub 2018 Sep 21.

Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany.

Background: Gunshot wounds and blast injuries to the upper limbs produce complex wounds requiring management by multiple surgical specialities.

Aim: We sought to determine the pattern of peripheral nerve injuries among Iraqi soldiers in the war.

Methods: We performed a 3 year retrospective cohort analysis based on medical records of patients with sustaining gunshot wounds and blast injuries to the upper limbs. Read More

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http://dx.doi.org/10.3889/oamjms.2018.346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182541PMC
September 2018
9 Reads

A case report of isolated distal upper extremity weakness due to cerebral metastasis involving the hand knob area.

BMC Cancer 2018 Oct 3;18(1):947. Epub 2018 Oct 3.

Department of Neurology, Semmelweis University, Balassa u. 6., H- 1083, Budapest, Hungary.

Background: Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of these, most frequently caused by a small lesion in the contralateral motor cortex of the brain. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4857-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171188PMC
October 2018
24 Reads

Fascicular Ratio Pilot Study: High-Resolution Neurosonography-A Possible Tool for Quantitative Assessment of Traumatic Peripheral Nerve Lesions Before and After Nerve Surgery.

Neurosurgery 2019 09;85(3):415-422

Department of Neurosurgery, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria.

Background: Clinical and electrophysiological assessments prevail in evaluation of traumatic nerve lesions and their regeneration following nerve surgery in humans. Recently, high-resolution neurosonography (HRNS) and magnetic resonance neurography have gained significant importance in peripheral nerve imaging. The use of the grey-scale-based "fascicular ratio" (FR) was established using both modalities allowing for quantitative assessment. Read More

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http://dx.doi.org/10.1093/neuros/nyy355DOI Listing
September 2019
38 Reads

Enhancing the Outcome of Traumatic Sensory Nerve Lesions of the Hand by Additional Use of a Chitosan Nerve Tube in Primary Nerve Repair: A Randomized Controlled Bicentric Trial.

Plast Reconstr Surg 2018 08;142(2):415-424

Ludwigshafen and Frankfurt am Main, Germany From the Department of Hand, Plastic and Reconstructive Surgery-Burn Center, BG Trauma Center Ludwigshafen; and the Department for Plastic, Hand and Reconstructive Surgery, BG Trauma Center Frankfurt am Main.

Background: Peripheral sensory nerve injuries present a significant yet common challenge in acute hand trauma surgery. Standard treatment remains microsurgical end-to-end nerve repair where appropriate. Permanent loss of sensitivity and painful neuroma formation are typical sequelae of unsuccessful surgery. Read More

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http://Insights.ovid.com/crossref?an=00006534-201808000-0002
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http://dx.doi.org/10.1097/PRS.0000000000004574DOI Listing
August 2018
19 Reads

Multislice computed tomographic measurements of optic nerve sheath diameter in brain injury patients.

Ulus Travma Acil Cerrahi Derg 2018 Jul;24(4):316-320

Department of Emergency Medicine, Celal Bayar University Faculty of Medicine, Manisa-Turkey.

Background: Currently, the measurement of optic nerve sheath diameter (ONSD) has been offered as a possible indicator of intracranial pressure (ICP). Increased ICP is observed during intracranial injury. The objective of this study was to evaluate the relationship between increased ONSD and positive intracranial findings from multislice computed tomography (CT) of the brain. Read More

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http://dx.doi.org/10.5505/tjtes.2017.27985DOI Listing
July 2018
6 Reads

Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress.

Neuropharmacology 2018 09 3;139:98-116. Epub 2018 Jul 3.

EA6309 Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, University of Limoges, Limoges, France. Electronic address:

Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present study was to investigate the effects of local and continuous treatment using low curcumin doses on functional recovery and nerve regeneration after rat sciatic nerve crush (SNC). Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.07.001DOI Listing
September 2018
29 Reads

Epigenetic Modifications Associated to Neuroinflammation and Neuropathic Pain After Neural Trauma.

Front Cell Neurosci 2018 7;12:158. Epub 2018 Jun 7.

Institut de Neurociències, Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Barcelona, Spain.

Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or diseases, producing a debilitation of the patient and a decrease of the quality of life. Read More

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http://dx.doi.org/10.3389/fncel.2018.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999732PMC
June 2018
3 Reads

[Traumatic lesions of the brachial plexus : Clinical symptoms, diagnostics and treatment].

Unfallchirurg 2018 Jun;121(6):483-496

Schwerpunkt für rekonstruktive Chirurgie bei Plexusparese, Tetraplegie und Cerebralparese, Abteilung für Hand‑, Replantations- und Mikrochirurgie, Unfallkrankenhaus Berlin, Warener Str. 7, 12683, Berlin, Deutschland.

Brachial plexus lesions mostly occur in young patients as a result of high-speed accidents. They are often diagnosed and treated after a delay. This has been shown to worsen the prognosis of surgical reconstructions evidently. Read More

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http://dx.doi.org/10.1007/s00113-018-0506-7DOI Listing
June 2018
5 Reads

Nerve ultrasound in emergency room: a case of traumatic ischiatic nerve neurotmesis.

Med Ultrason 2018 May;20(2):255-256

Department of Radiology, Polyclinic San Martino, Genoa, Italy.

A 22 years-old-man was admitted to emergency after trauma. He suffered multiple deep cuts on his left leg. A lesion of the ischiatic nerve was suspected, and an ultrasound (US) evaluation was requested to confirm it. Read More

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http://dx.doi.org/10.11152/mu-1446DOI Listing
May 2018
9 Reads

Ultrasound Diagnosis of Postoperative Complications of Nerve Repair.

World Neurosurg 2018 Jul 3;115:320-323. Epub 2018 May 3.

IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy; Department of Geriatrics, Neurosciences and Orthopaedics, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

Background: Peripheral nerve injuries often undergo surgical repair, but poor postoperative functional recovery is frequently observed.

Case Description: We describe 4 cases of traumatic nerve lesions in whom postoperative recovery was prevented by complications such as detachment of nerve sutures or neuroma growth. To the best of our knowledge, no similar cases have been reported in literature so far. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.179DOI Listing
July 2018
7 Reads

[Improved diagnostics and therapeutic decision making in traumatic peripheral nerve lesions using MR-neurography].

Handchir Mikrochir Plast Chir 2018 Aug 25;50(4):232-240. Epub 2018 Apr 25.

Universitätsklinikum Heidelberg AG MR-Neurographie, Abteilung für Neuroradiologie, Neurologische Klinik.

Introduction: The correct diagnosis of peripheral nerve injuries is essential for choosing the correct treatment in nerve surgery. Especially, nerve defects require early diagnosis to provide quick surgical reconstruction and prevent long-term disabilities. Recent developments in MR-neurography provide surgeons with a diagnostic tool delivering precise information on the structure and possibly function of nerves. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-101833
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http://dx.doi.org/10.1055/s-0044-101833DOI Listing
August 2018
26 Reads

Challenges of Managing Patients with Symptomatic Large Traumatic Cervical Pseudomeningoceles.

World Neurosurg 2018 Jul 11;115:128-133. Epub 2018 Apr 11.

Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Background: Traumatic cervical pseudomeningoceles (TCPs) occur secondary to traction of the cervical nerve roots resulting in violation of the dura. Surgical repair is not necessary in most cases because pseudomeningoceles have a high propensity to spontaneously resolve with conservative management alone. Currently, there are a limited number of cases of large TCPs (large is defined as ≥6 cm in greatest diameter), and there is no established guideline for the management of such lesions. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.017DOI Listing
July 2018
41 Reads
2.420 Impact Factor

Total Transcanal Endoscopic Facial Nerve Decompression for Traumatic Facial Nerve Palsy.

Yonsei Med J 2018 May;59(3):457-460

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

A few approaches can be used to decompress traumatic facial nerve paralysis including the middle cranial fossa approach or transmastoid approach depending on the site of injury. In some specific situation of treating traumatic facial nerve palsy whose injured site was confined from the geniculate ganglion to the second genu, transcanal endoscopic approach for facial nerve decompression can be used. We performed two cases of total endoscopic transcanal facial nerve decompression in patients with traumatic facial nerve palsy. Read More

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http://dx.doi.org/10.3349/ymj.2018.59.3.457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890000PMC
May 2018
8 Reads

Early nerve repair in traumatic brachial plexus injuries in adults: treatment algorithm and first experiences.

J Neurosurg 2018 01;130(1):172-178

Objective: The object of this study was to assess the advantages and disadvantages of early nerve repair within 2 weeks following adult traumatic brachial plexus injury (ATBPI).

Methods: From 2009 onwards, the authors have strived to repair as early as possible extended C-5 to C-8 or T-1 lesions or complete loss of C-5 to C-6 or C-7 function in patients in whom there was clinical and radiological suspicion of root avulsion. Among a group of 36 patients surgically treated in the period between 2009 and 2011, surgical findings in those who had undergone treatment within 2 weeks after trauma were retrospectively compared with results in those who had undergone delayed treatment. Read More

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http://dx.doi.org/10.3171/2017.7.JNS17365DOI Listing
January 2018
4 Reads

Management of Hemophilic Cysts and Pseudotumors of the Hand in Bleeding Disorders: A Case Series.

J Hand Surg Am 2018 05 18;43(5):486.e1-486.e9. Epub 2017 Dec 18.

Department of Hematology, Christian Medical College & Hospital, Vellore, Tamil Nadu, India.

Purpose: Hemophilic cysts and pseudotumors (HCPTs) of the hand are rare and are secondary to bleeding disorders such as hemophilia A and B. This is a report of our experience in the management of this rare condition.

Patients And Methods: Seven male patients with hemophilia A presenting with progressive swelling of the hand were treated between 2004 and 2013 at a tertiary referral hospital. Read More

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http://dx.doi.org/10.1016/j.jhsa.2017.10.035DOI Listing
May 2018
15 Reads
1.655 Impact Factor

Aberrant expression of thyroid transcription factor-1 in schwannomas.

Hum Pathol 2018 01 5;71:84-90. Epub 2017 Dec 5.

Department of Pathology, Taihe Hospital, Hubei University of Medicine, Hubei, China 442000. Electronic address:

Aberrant expression of thyroid transcription factor-1 (TTF-1) has been observed in tumors arising in locations other than thyroid gland, lung and ventral forebrain. However, TTF-1 expression in schwannomas has not yet been studied. Meanwhile, a few inconsistent changes in protein expression have been identified between schwannomas and other peripheral nerve sheath tumors. Read More

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http://dx.doi.org/10.1016/j.humpath.2017.10.025DOI Listing
January 2018
8 Reads

Anatomy of the olfactory nerve: A comprehensive review with cadaveric dissection.

Clin Anat 2018 Jan 10;31(1):109-117. Epub 2017 Nov 10.

Servicio de Neurocirugía, Hospital General Dr. Valentín Gómez Farías, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Guadalajara, Jalisco, 45100, Mexico.

Because of their anatomical situation, the olfactory nerves constitute a natural obstacle to exploring the anterior cranial fossa, making them vulnerable to traumatic, tumor, or iatrogenic lesions. Consequently, accurate knowledge of their microsurgical anatomy is of particular importance for surgeons to ensure the correct execution of surgical procedures with minimal sequelae, the least functional deterioration, and better therapeutic results. This review describes the functional and microsurgical anatomy of the olfactory nerves, illustrated with pictures of simulations based on cadaveric dissections and original illustrations of the central connections of the olfactory pathway. Read More

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http://dx.doi.org/10.1002/ca.23003DOI Listing
January 2018
2 Reads

Eccrine spiradenoma mimicking a painful traumatic neuroma: case report.

J Neurosurg 2018 09 27;129(3):825-828. Epub 2017 Oct 27.

2Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health.

Diagnosing and treating patients with persistent neuropathic pain associated with peripheral nerve lesions can be challenging. The authors report the rare case of a painful eccrine spiradenoma treated as a traumatic neuroma for many years because of a history of acute trauma, the presence of a tender palpable mass, and symptoms of allodynia. Surgical excision of the neoplasm completely relieved the pain and hypersensitivity that 2 prior surgeries and other nonsurgical treatments failed to resolve. Read More

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http://dx.doi.org/10.3171/2017.5.JNS162999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087503PMC
September 2018
36 Reads
3.740 Impact Factor

Efficient Imaging: Examining the Value of Ultrasound in the Diagnosis of Traumatic Adult Brachial Plexus Injuries, A Systematic Review.

Neurosurgery 2018 09;83(3):323-332

Division of Plastic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Background: Traumatic brachial plexus injury (BPI) can result in debilitating sequelae of the upper extremity. Presently, therapeutic decisions are based on the mechanism of injury, serial physical examination, electromyography, nerve conduction, and imaging studies. While magnetic resonance imaging is the current imaging modality of choice for BPI, ultrasound is a promising newcomer that is inexpensive, accessible, and available at point of care. Read More

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http://dx.doi.org/10.1093/neuros/nyx483DOI Listing
September 2018
19 Reads