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Am Surg 2019 Mar;85(3):266-272

Present literature seems to support the nonoperative management of penetrating renal trauma although data remain limited. We conducted a nine-year retrospective review of nonoperative operative management and mechanism of injury [stab wound (SW) gunshot wound (GSW)] among patients admitted with penetrating renal trauma. Of 203 patients, the median age was 24 years, with the majority being male and having GSW injuries. Read More

World J Urol 2019 Mar 30. Epub 2019 Mar 30.

Department of Urology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 101 Manning Drive, 2nd floor, Chapel Hill, NC, USA.

Purpose: Limited data exist on the characteristics, risk factors, and management of blunt trauma pelvic fractures causing genitourinary (GU) and lower gastrointestinal (GI) injury. We sought to determine these parameters and elucidate independent risk factors.

Methods: The National Trauma Data Bank for years 2010-2014 was queried for pelvic fractures by ICD-9-CM codes. Read More

Am J Obstet Gynecol 2019 Mar 26. Epub 2019 Mar 26.

Center for Urogynecology & Pelvic Reconstructive Surgery, Obstetrics, Gynecology & Women's Health Institute, Cleveland Clinic, Cleveland, OH.

Objective: To describe the incidence of and factors associated with lower urinary tract (LUT) complications recognized in the immediate postoperative period following hysterectomy for benign gynecologic indications using the National Surgical Quality Improvement Program (NSQIP) database.

Methods: Patients who underwent hysterectomy for benign indications from 2014 through 2016 were identified in the NSQIP database using Current Procedural Terminology codes and International Classification of Diseases codes. Patient demographics, preoperative comorbidities, American Society of Anesthesiologists (ASA) classification system scores and total operating time were collected. Read More

Curr Urol Rep 2019 Mar 23;20(5):21. Epub 2019 Mar 23.

Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Ste 1100, Philadelphia, PA, 19107, USA.

Purpose Of Review: We highlight the substantial gaps in knowledge on urologic care of female spinal cord injury (SCI) patients.

Recent Findings: Males account for approximately 80% of people living with SCI in developed nations. Although there is a robust body of literature in some aspects of urologic care of individuals with SCI, such as treatments for neurogenic detrusor overactivity, there are relatively few studies focusing specifically on females. Read More

Obstet Gynecol Int 2019 10;2019:6456141. Epub 2019 Feb 10.

Genitourinary/Urogynaecology Unit, Faculty of Clinical Science, UI, Ibadan, Nigeria.

Background: Ureteric injuries leading to ureterovaginal fistula (UVF) is less common than vesicovaginal fistula, as a cause of urinary incontinence. Recently, there is a surge in the number of UVF cases presenting to University College Hospital (UCH) following a caesarean delivery. The urogynaecology unit at UCH is at the forefront of providing surgical repair for women with all forms of genitourinary fistulas. Read More

Cochrane Database Syst Rev 2019 02 6;2:CD012703. Epub 2019 Feb 6.

Department of Urology, University of Minnesota, 420 Delaware Street SE, MMC 394, Minneapolis, Minnesota, USA.

Background: Ureteroscopy combined with laser stone fragmentation and basketing is a common approach for managing renal and ureteral stones. This procedure is associated with some degree of ureteral trauma. Ureteral trauma may lead to swelling, ureteral obstruction, and flank pain and may require subsequent interventions such as hospital admission or secondary ureteral stent placement. Read More

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):50-53

Department of Urology, Toyohashi Municipal Hospital.

A 77-year-old man with a right kidney stone was admitted to our hospital. A ureteroscope was introduced into the ureter without dilation under direct vision. We then performed flexible transurethral lithotripsy (f-TUL) using a ureteral access sheath and successfully fragmented the stone and extracted almost all the stone fragments without any complications. Read More

Anticancer Res 2019 Jan;39(1):477-486

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

Background/aim: To evaluate the treatment outcomes, toxicity and health-related quality of life (HRQOL) in prostate cancer (PCa) patients who underwent single-fraction high-dose-rate brachytherapy (single-fraction HDR-BT) with external beam radiotherapy (EBRT).

Materials And Methods: From April 2014 to October 2017, treatment outcomes and toxicity of 85 patients who underwent single-fraction HDR-BT of 13 Gy, followed by 46 Gy EBRT in 23 fractions, were examined. HRQOL of 53 patients was evaluated using the Expanded Prostate Cancer Index Composite (EPIC), International Prostate Symptom Score (IPSS)/QOL index, International Index of Erectile Function 5 (IIEF-5), and 36-Item Short Form Survey (SF-36) scores through one year. Read More

Eur Urol 2019 03 17;75(3):464-476. Epub 2018 Dec 17.

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Context: Radiotherapy used for treating localized prostate cancer is effective at prolonging cancer-specific and overall survival. Still, acute and late pelvic toxicities are a concern, with gastrointestinal (GI) and genitourinary (GU) sequelae being most common as well as other pelvic complications.

Objective: To present a critical review of the literature regarding the incidence and risk factors of pelvic toxicity following primary radiotherapy for prostate cancer and to provide a narrative review regarding its management. Read More

Ecotoxicol Environ Saf 2019 Apr 10;170:331-337. Epub 2018 Dec 10.

Department of Biology, University of Louisiana at Lafayette, Box 43602, Lafayette, LA 70504, USA.

The widespread use of the synthetic estrogen 17 α-ethinylestradiol (EE) has resulted in elevated levels in aquatic environments, where it is known to act as an endocrine disrupting chemical affecting fish and other aquatic organisms. Examining changes in the structure of the fish' gonads and liver has proven to be an effective approach for assessing these impacts. While changes have been reported for various fish species, it is not clear whether impacts are equally severe in live-bearing fishes. Read More

Poult Sci 2019 Apr;98(4):1589-1600

Center for Proper Housing: Poultry and Rabbits (ZTHZ), Animal Welfare Division, VPH Institute, University of Bern, 3052 Zollikofen, Switzerland.

The aim of this study was to investigate the effect of keel bone fracture (KBF) severity and healing activity on individual productivity of laying hens. Focal hens (75 Lohmann Selected Leghorn (LSL), 75 Lohmann Brown (LB)) were housed alongside non-focal hens in 10 identical pens containing a commercial aviary system (15 focal hens per pen). Eggs of focal hens were identified by orally administering a dye on 3 consecutive days, resulting in a hen-specific color pattern in the yolk. Read More

Dermatol Clin 2019 Jan;37(1):117-128

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Dermatologic SurgiCenter, 1200 Locust Street, Philadelphia, PA 19107, USA. Electronic address:

Topical silicone gel is more beneficial than petrolatum-based products as an all-purpose wound dressing for granulating and sutured wounds, regardless of cause. Vaginal laser rejuvenation is effective in relieving genitourinary syndrome of menopause, stress urinary incontinence, vaginal relaxation syndrome, and related vulvar disorders. New cosmetic indications in the upper face for onabotulinumtoxinA have been approved by the Food and Drug Administration, whereas off-label treatments in the lower face increase in popularity. Read More

Urology 2019 Feb 14;124:260-263. Epub 2018 Nov 14.

Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT.

Objective: To examine the rate of urethral trauma and pubic symphysis diastasis in saddle horn injury, which occurs when horseback riders are bucked into the air and land with their perineum striking the rigid saddle horn, compared to pelvic fracture from other mechanisms.

Methods: A retrospective review was performed of male patients presenting to our level-1 trauma center with pelvic ring fractures between January 1, 2001 and December 30, 2016. Demographics, injury severity score, mechanism of injury (saddle horn vs other), pubic symphysis diastasis, and lower genitourinary (GU) injuries (bladder and urethra) were identified in the trauma registry. Read More

Int J Mol Med 2019 Jan 8;43(1):305-315. Epub 2018 Nov 8.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China.

The primary aim of the present study was to investigate the potential effect of high‑pressure carbon dioxide (CO2) pneumoperitoneum on kidneys with severe hydronephrosis and to investigate the possible underlying mechanism. A total of 18 rabbits underwent a surgical procedure inducing severe hydronephrosis. Rabbits were then divided at random into three groups (n=6 each) and subjected to intraabdominal pressure of 0, 8 or 18 mmHg, respectively. Read More

World J Urol 2018 Nov 7. Epub 2018 Nov 7.

Department of Urology, Columbia University Medical Center, 161 Ft. Washington Ave 11th Floor, New York, NY, 10032, USA.

Purpose: Hysterectomy (Hys) is the most common non-urologic surgery associated with iatrogenic genitourinary (GU) injury. We present the largest known population-based evaluation of GU injury related to benign Hys.

Methods: The New York Statewide Planning and Research Cooperative System (SPARCS) was queried by ICD-9 and CPT codes. Read More

Turk J Med Sci 2018 Oct 31;48(5):1073-1079. Epub 2018 Oct 31.

Objectives: We observed the efficacy of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields. Materials and methods: Forty rats were divided into four treatment groups: Group 1, control group (n = 10); Group 2, melatonin administration only (n = 10); Group 3, magnetic field exposure only (n = 10); Group 4, magnetic field exposure with melatonin administration (n = 10). The magnetic field was applied at a dose of 20 μT for 30 min/day for 10 days. Read More

Cochrane Database Syst Rev 2018 10 26;10:CD007554. Epub 2018 Oct 26.

Department of Renal Medicine, Singapore General Hospital, 20 College Street, Singapore, Singapore, 169856.

Background: Biocompatible peritoneal dialysis (PD) solutions, including neutral pH, low glucose degradation product (GDP) solutions and icodextrin, have previously been shown to favourably influence some patient-level outcomes, albeit based on generally sub-optimal quality studies. Several additional randomised controlled trials (RCT) evaluating biocompatible solutions in PD patients have been published recently. This is an update of a review first published in 2014. Read More

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2803-2806. Epub 2018 Oct 26.

Department of Radiotherapy Planning, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland. Email:

Background: The purpose of this study was to compare hematologic adverse effects and hematologic toxicity (HT) of pelvic irradiation in patients treated with conformal radiotherapy (CRT) and intensity modulated radiotherapy (IMRT) for radical treatment of prostate and bladder cancer. Methods: A group of 115 patients with prostate or bladder cancer treated with definitive radical radiotherapy was evaluated retrospectively. Blood test were taken before and after treatment comprising of following indices: white blood cells (WBC) hemoglobin (HGB), red blood cell (RBC), lymphocyte (LC), neutrophil (NC) and platelet (PLT) count. Read More

JSLS 2018 Jul-Sep;22(3)

Département de gynécologie du CHU de Québec - Université Laval, Québec, QC, Canada.

Background And Objectives: Laparoscopic hysterectomy poses the risk of lower urinary tract injury, and intraoperative recognition of urinary tract injury is often difficult. We sought to evaluate sodium fluorescein coloration of ureteral jets during cystoscopy after laparoscopic hysterectomy and to evaluate surgeons' satisfaction with this method of injury detection.

Methods: This was an observational study, in which data were collected prospectively. Read More

Nutrients 2018 Oct 17;10(10). Epub 2018 Oct 17.

Department of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan.

Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day N-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. Read More

J Gynecol Obstet Hum Reprod 2019 Jan 12;48(1):45-49. Epub 2018 Oct 12.

Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital Izmir, Turkey. Electronic address:

Objectives: Determining the incidence and causes of lower urinary tract injury in patients undergoing total laparoscopic hysterectomy and examining the procedures applied for management.

Methods: Patients who underwent total laparoscopic hysterectomy in a large referral center between 1 January 2015 and 31 October 2017 for benign gynecological reasons were included in the study. Patients who underwent laparoscopic supracervical hysterectomy, laparoscopy-assisted vaginal hysterectomy and robot-assisted laparoscopic hysterectomy were not included in this study. Read More

Zhonghua Shao Shang Za Zhi 2018 Sep;34(9):629-636

Department of Burns, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To explore the influences of hydrogen-rich saline on acute kidney injury in severely burned rats and to analyze the related mechanism. Fifty-six Sprague Dawley rats were divided into sham injury group (=8), burn group (=24), and hydrogen-rich saline group (=24) according to the random number table. Rats in sham injury group were treated by 20 ℃ water bath on the back for 15 s to simulate injury, and rats in burn group and hydrogen-rich saline group were inflicted with 30% total body surface area (TBSA) full-thickness scald (hereinafter referred to as burns) by 100 ℃ water bath on the back for 15 s. Read More

Eur J Pediatr 2019 Jan 2;178(1):77-80. Epub 2018 Oct 2.

Department of Pediatric Surgery, School of Medicine, Koç University Hospital, Topkapı, Maltepe, 34010, Istanbul, Turkey.

Mechanical and chemical trauma are a widely accepted theories to explain the pathogenesis of meatalstenosis after newborn circumcision. The aim of the present study was to explore the theory that an exposed glans is prone to meatal stenosis. This was done by a novel investigation of boys who were born with "hooded prepuce", a condition in which the glans is completely exposed. Read More

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Nephrocutaneous fistula is a rare complication of surgical procedures involving the kidney. Fistula formation is also a complication seen in gossypiboma. We present the case of a patient who was initially suspected to have nephrocutaneous fistula after open pyelolithotomy. Read More

Pain Med 2018 Sep 24. Epub 2018 Sep 24.

Department of Psychology, Wayne State University, Detroit, Michigan.

Objective: Women with chronic urogenital pain (CUP) conditions have elevated rates of lifetime trauma, relational stress, and emotional conflicts, but directly assessing and treating psychological stress is rarely done in women's health care settings. We developed and tested the effects on patients' somatic and psychological symptoms of a life stress interview that encourages disclosure about stressors and uses experiential techniques to increase awareness of links between stress, emotions, and symptoms.

Methods: In this randomized trial, women with CUP recruited at a multidisciplinary women's urology center received either a single 90-minute life stress interview (N = 37) or no interview (treatment-as-usual control; N = 25). Read More

Vet Parasitol 2018 Aug 29;260:22-29. Epub 2018 Jul 29.

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, Onderstepoort 0110, South Africa.

The occurrence of acute kidney injury in canine babesiosis is not well documented. Furthermore, interpretation of urine specific gravity (USG) to assess renal concentrating ability is hampered by the frequent presence of hemoglobinuria in this disease. This cross-sectional study aimed to test the hypothesis that renal azotemia (RA) is underdiagnosed according to current canine babesiosis literature by determining its occurrence at presentation, using urine osmolality instead of USG to measure urinary concentration. Read More

Ther Adv Urol 2018 Oct 10;10(10):295-303. Epub 2018 Jul 10.

Department of Urology, The Chaim Sheba Medical Center, 2 Sheba Road, Tel Hashomer, 5262100, Israel.

The kidneys are the most vulnerable genitourinary organ in trauma, as they are involved in up to 3.25% of trauma patients. The most common mechanism for renal injury is blunt trauma (predominantly by motor vehicle accidents and falls), while penetrating trauma (mainly caused by firearms and stab wound) comprise the rest. Read More

Zhonghua Nan Ke Xue 2018 08;24(8):681-685

Center of Reproduction, The Sixth Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510620, China.

Objective: To investigate the value of micro- dissection testicular sperm extraction (micro-TESE) in the treatment of non-obstructive azoospermia (NOA) in patients with the history of secondary testicular injury.

Methods: Totally, 121 NOA patients with the history of secondary testicular injury underwent micro-TESE in our hospital from September 2014 to December 2017. We analyzed the correlation of the sperm retrieval rate with the causes of testicular injury and compared the outcomes of the ICSI cycles with the sperm retrieved from the NOA males by micro-TESE (the micro-TESE group) and those with the sperm ejaculated from severe oligospermia patients (sperm concentration <1×10⁶/ml, the ejaculate group). Read More

Zhonghua Nan Ke Xue 2018 Apr;24(4):335-339

Center of Urology and Nephrology, Ningbo First Hospital / Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang 315010, China.

Objective: To search for a safe and effective method of penoplasty with low incidence of complications for concealed penis by evaluating penoplasty with T-shaped incision and three-point fixation in comparison with modified Devine's technique.

Methods: We retrospectively analyzed 169 cases of concealed penis treated in our center by penoplasty with T-shaped incision and three-point fixation (group A, n = 110) or modified Devine's surgery (group B, n = 59). We compared the operation time, postoperative complications, and recurrence rate between the two groups of patients. Read More

Mil Med Res 2018 08 26;5(1):29. Epub 2018 Aug 26.

Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore, Singapore.

Background: The pubic region is often involved in accidental hot water or soup-spill burns. Most of these wounds are superficial partial thickness burns. Due to their proximity to the urinary system, as well as vaginal and anal openings, these burns are easily contaminated. Read More

PLoS One 2018 24;13(8):e0202901. Epub 2018 Aug 24.

Laboratory of Renal Physiopathology, INC Ignacio Chavez, Mexico City, Mexico.

Hyperuricemia is highly prevalent and especially common in subjects with metabolic, cardiovascular and renal diseases. In chronic kidney disease, hyperuricemia is extremely common, and uric acid (UA) excretion relies on gut uricolysis by gut microbiota. Current therapy for lowering serum UA includes drugs that may produce undesired secondary effects. Read More

Wei Sheng Yan Jiu 2018 May;47(3):459-464

College of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Objective: To study the renal damage of indium sulfate.

Methods: 32 healthy Wistar rats were randomly and equally divided into 3 dose groups( 52. 3 mg/kg、104. Read More

Environ Sci Pollut Res Int 2018 Sep 25;25(27):27463-27470. Epub 2018 Jul 25.

Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.

Spirulina platensis (SP) is a traditionally used microalga for a wide range of pharmacological activities, including amelioration of heavy metals and pesticides toxicity. This study evaluated the antioxidant and organoprotective effects of SP against diazinon (DZN)-induced subacute toxicity on the blood, heart, liver, and kidneys of male Wistar albino rats. Diazinon (20 mg/kg, subcutaneous) was administered to animals either alone or along with an oral pure SP powder at doses of 500 and 1000 mg/kg. Read More

Sci Total Environ 2018 Dec 17;645:297-317. Epub 2018 Jul 17.

Department of Biological Sciences, BITS Pilani, K K Birla Goa Campus, NH 17 B, Zuarinagar, Goa 403 726, India. Electronic address:

Silica is a trace-geogenic compound with limited-bioavailability. It inflicts health-perils like pulmonary-silicosis and chronic kidney disease (CKD), when available via anthropogenic-disturbances. Amidst silica-imposed pathologies, pulmonary toxicological-mechanisms are well-described, ignoring the renal-pathophysiological mechanisms. Read More

Kidney Blood Press Res 2018 17;43(4):1131-1140. Epub 2018 Jul 17.

Department of Nephrology, Fujian Provincial Hospital, Fuzhou, China.

Background/aims: The aim of the study was to investigate clinicopathological characteristics, the role of immunosuppressive therapy and renal outcome in IgA nephropathy (IgAN) patients with hyperuricemia.

Methods: 206 biopsy-proven primary IgAN patients were included between January 2010 and December 2015, and divided into two groups: patients without hyperuricemia (n=122), and patients with hyperuricemia (n=84). The clinicopathological features, response, renal outcome and safety were recorded. Read More

J Robot Surg 2019 Apr 16;13(2):289-292. Epub 2018 Jul 16.

Department of Genitourinary Oncology, MCC-GU Program, H. Lee Moffitt Cancer Center and Research Institute and University of South Florida Morsani College of Medicine, Magnolia Drive, Tampa, FL, 33612, USA.

Urologic injury is an infrequent but serious complication of pelvic surgery. Training in the assessment and management of this injury might be enhanced through animated simulation. Our objective was to assess the intraoperative management of urologic injury with robotic pelvic surgery using a simulated injury animal model. Read More

Radiat Oncol 2018 Jul 16;13(1):129. Epub 2018 Jul 16.

Department of Radiation Oncology, University of Virginia School of Medicine, 1240 Lee Street, Box 800383, Charlottesville, VA, 22908, USA.

Background: Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. The American Brachytherapy Society has published guidelines for high dose rate (HDR) BT with recommended dose limits. However, recent reports suggest lower doses may be needed to avoid toxicity. Read More

Expert Rev Clin Pharmacol 2018 Aug 25;11(8):819-824. Epub 2018 Jul 25.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Objectives: Clinical and subclinical laboratory evidence of renal proximal tubular dysfunction had been reported in children with epilepsy as an adverse effect of some antiepileptic drugs (AEDs). This study aimed to determine kidney function in adult patients with monosymptomatic epilepsy of unknown etiology and treated with valproate (VPA) or carbamazepine (CBZ).

Methods: This study included 60 patients [mean age of 33. Read More

BMC Womens Health 2018 07 11;18(1):124. Epub 2018 Jul 11.

Department of Urology, Guangdong Women and Children Hospital, Guangzhou, 510010, Guangdong, China.

Background: Bladder rupture caused by trauma or pelvic fracture is very common, and can be easily diagnosed. However, Spontaneous rupture of the bladder is rare. Reported by Peters PC. Read More

Neurosci Lett 2018 09 28;683:100-103. Epub 2018 Jun 28.

Department of Urology, University of Pittsburgh, Pittsburgh, PA, 15213, United States; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, United States. Electronic address:

Nerve growth factor (NGF) is reportedly involved in the changes in C-fiber bladder afferent pathways that induce detrusor overactivity (DO) following spinal cord injury (SCI). This study examined the roles of NGF in TRP channel expression in bladder afferent neurons in mice with SCI using laser-capture microdissection (LCM) methods. Spinal intact (SI) and SCI mice were divided into 3 groups: (1) SI with vehicle treatment; (2) SCI with vehicle treatment; and (3) SCI with anti-NGF antibody. Read More

J Obstet Gynaecol Res 2018 Aug 28;44(8):1487-1491. Epub 2018 Jun 28.

Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.

A 44-year-old multipara woman was referred because of the sudden onset of left lower abdominal pain. Corpus luteum hematoma was suspected and conservatively managed. Two days later, due to worsening of abdominal symptoms, emergency laparoscopic surgery was performed. Read More

Int J Mol Sci 2018 Jun 25;19(7). Epub 2018 Jun 25.

Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda #340, Santiago 8331150, Chile.

Boldine, a major aporphine alkaloid found in the Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimental role in the pathogenesis of kidney damage in renovascular hypertension (RVH). The activation of the renin-angiotensin system (RAS) is crucial to the development and progression of hypertensive renal damage and TGF-β is closely associated with the activation of RAS. Read More

PLoS One 2018 20;13(6):e0198013. Epub 2018 Jun 20.

Division of Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America.

Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation. A number of studies have shown decrease in expression of nephrin in various proteinuric kidney diseases as well as in animal models of glomerular disease. Read More

Taiwan J Obstet Gynecol 2018 Jun;57(3):464-465

Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Tianhe District, Guangzhou, Guangdong, 510623, China. Electronic address:

Kidney Blood Press Res 2018 30;43(3):847-859. Epub 2018 May 30.

Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China.

Background/aims: Renal pathological changes affect the motion of water molecules, which can be detected using diffusion-weighted imaging (DWI). The current study was performed to explore the correlation between renal tissue pathological injuries and DWI iconographical parameters in lupus nephritis (LN).

Methods: Twenty adult patients with LN and 11 healthy volunteers were recruited. Read More

In Vitro Cell Dev Biol Anim 2018 Jun 29;54(6):430-438. Epub 2018 May 29.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 845 Lingshan Road, Shanghai, 200135, China.

Vitrification of oocytes is closely associated with the lower embryonic developmental potential, which involves the cryopreservation injury occurred during vitrification. It indicates that vitrification may need to be further optimized. Therefore, we studied the effects of resveratrol, an antioxidant, on the developmental potential of vitrified mouse oocytes after in vitro fertilization. Read More

World J Urol 2018 Oct 29;36(10):1545-1553. Epub 2018 May 29.

USC Institute of Urology, 1441 Eastlake Avenue, suite 7414, Los Angeles, CA, 90033, USA.

Purpose: Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neurogenic bladder, describe common complications of this disease, and address strategies for their management. Read More

Biomed Pharmacother 2018 Jan 20;97:1486-1492. Epub 2017 Nov 20.

Department of Medical Pharmacology, School of Medicine, Cukurova University, Adana, Turkey.

Methotrexate (MTX) is frequently used in the treatment of several diseases including cancers, rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and dermatomyositis. Previously, chemotherapeutic agents have been reported to cause permanent azoospermia and infertility in men. Methotrexate has been also shown to damage the seminiferous tubules of the testicles, lower the sperm count, and cause genetic mutations (in DNA) in sperm. Read More

Radiother Oncol 2018 06 18;127(3):423-430. Epub 2018 May 18.

Department of Oncology, Aarhus University Hospital, Denmark.

Background And Purpose: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO).

Material And Methods: A total of 1176 patients were analysed. Read More

J Gynecol Obstet Hum Reprod 2018 Sep 18;47(7):289-297. Epub 2018 May 18.

Department of Urology, Private Hospital Sainte Marie, Ramsay General de Santé, 4 allée Saint Jean des Vignes, 71100 Chalon-sur-Saône, France.

Introduction: The mid-urethral sling (MUS) procedure is the gold-standard for the surgical treatment of stress urinary incontinence (SUI). Urethro-vesical sling exposure is one of the most serious complications of this procedure. We describe the treatment and follow-up of 18 patients with bladder or urethral sling exposure. Read More