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Cells 2022 Apr 20;11(9). Epub 2022 Apr 20.

Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

The recovery of lower-urinary-tract activity is a top priority for patients with spinal-cord injury. Historically, locomotor training improved micturition function in both patients with spinal cord injury and animal models. We explore whether training augments such as the supraspinal control of the external urethral sphincter results in enhanced coordination in detrusor-sphincter activity. Read More

Mil Med 2022 May;187(Supplement_2):42-51

Infectious Disease Clinical Research Program, Preventive Medicine & Biostatistics Department, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Introduction: During the wars in Iraq and Afghanistan, increased incidence of multidrug-resistant (MDR) organisms, as well as polymicrobial wounds and infections, complicated the management of combat trauma-related infections. Multidrug resistance and wound microbiology are a research focus of the Trauma Infectious Disease Outcomes Study (TIDOS), an Infectious Disease Clinical Research Program, Uniformed Services University, research protocol. To conduct comprehensive microbiological research with the goal of improving the understanding of the complicated etiology of wound infections, the TIDOS MDR and Virulent Organisms Trauma Infections Initiative (MDR/VO Initiative) was established as a collaborative effort with the Brooke Army Medical Center, Naval Medical Research Center, U. Read More

Ulus Travma Acil Cerrahi Derg 2022 Mar;28(3):344-351

Department of Medical Biology, Suleyman Demirel University Faculty of Medicine, Isparta-Turkey.

Background: Background: Renal ischemia-reperfusion injury (RIRI) is the most frequent cause of acute renal failure in clinical conditions such as trauma and shock as well as renal surgeries. Oxerutin is a member of the flavonoid family and possesses antioxidant properties. The aim of this study was to investigate whether oxerutin has protective effects on RIRI. Read More

J Med Case Rep 2022 Apr 20;16(1):157. Epub 2022 Apr 20.

Geriatric Medicine, St John of God Midland Public and Private Hospitals, 1 Clayton St, Midland, WA, 6056, Australia.

Background: Veillonella species are an opportunistically pathogenic commensal anaerobic Gram-negative coccus commonly found in the oral, genitourinary, respiratory, and intestinal tract of humans and some animals. Infection is rare, even in immunocompromised hosts, and has been identified to cause a wide array of different infections, including endocarditis, osteomyelitis, and meningitis.

Case Presentation: An 82-year-old Caucasian male retired ex-gymnast presented to the emergency department with a 2-week history of acute on chronic lower back pain without clear precipitant. Read More

Eur J Obstet Gynecol Reprod Biol 2022 May 9;272:253-254. Epub 2022 Apr 9.

University Department of Gynecology and Obstetrics, Clinical Hospital "Sveti Duh" Zagreb, School of Medicine, Catholic University of Croatia Zagreb, Croatia.

BMJ Case Rep 2022 Apr 6;15(4). Epub 2022 Apr 6.

Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

A 36-year-old woman presented with problems of lower urinary tract symptoms for 2 years duration. Patient was being managed as a case of urethral stricture with routine calibration. Micturating cystourethrogram showed failure of bladder neck to open. Read More

Spinal Cord 2022 May 4;60(5):382-394. Epub 2022 Apr 4.

Univ. Lille, Inserm UMR-S1172 LilNCog, Lille Neuroscience and Cognition, CHU Lille, F-59000, Lille, France.

Study Design: Systematic review.

Objectives: To synthetise the available scientific literature reporting early interventions to prevent neurogenic lower urinary tract dysfunction (NLUTD) after acute supra-sacral spinal cord injury (SCI).

Methods: The present systematic review is reported according to the PRISMA guidelines and identified articles published through April 2021 in the PubMed, Embase, ScienceDirect and Scopus databases with terms for early interventions to prevent NLUTD after SCI. Read More

Kidney360 2022 Feb 8;3(2):337-340. Epub 2021 Dec 8.

Division of Nephrology-Hypertension, University of California San Diego, San Diego, California.

Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD. Read More

Neurourol Urodyn 2022 04 29;41(4):980-990. Epub 2022 Mar 29.

Department of Surgery and Epidemiology and Biostatistics, Western University, London, Ontario, Canada.

Objective: To compare bladder symptoms, and urinary and overall quality of life (QOL) among women and men after Spinal cord injury (SCI), and to describe specific aspects of QOL among women with SCI.

Methods: We used data from a prospective, multi-center, and cross-sectional study that was carried out from May 2019 to September 2020. Clinical and demographic details were obtained and participants completed two patient reported outcomes: the neurogenic bladder symptoms score-short form (NBSS-SF, which measures bladder symptoms and QOL) and the SF-12 (which measures overall physical and mental health QOL). Read More

Neurourol Urodyn 2022 04 23;41(4):991-1001. Epub 2022 Mar 23.

Department of Surgery, Division of Urology, Thammasat University Hospital, Pathum Thani, Thailand.

Introduction: Low-compliance bladder or high bladder pressure undoubtedly leads to hydronephrosis and renal impairment. As four decades have elapsed since a previous study found a detrusor leak-point pressure (DLPP) >40 cm H O to result in hydronephrosis, we suspected the possibility of hydronephrosis or vesicoureteral reflux occurring at any point below the 40 cm H O DLPP reference. Therefore, this study aimed to determine the storage detrusor pressure value and risk factors related to upper urinary tract damage (UUTD). Read More

Front Med (Lausanne) 2022 24;9:792323. Epub 2022 Feb 24.

Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: is a small cell-wall-free organism, part of the normal microbiota of the genitourinary tract. It is rarely involved in extragenital infections, mainly joint, surgical-site, and respiratory infections.

Methods: We describe a case of subdural empyema and lower limb surgical site infections, following decompressive craniotomy, after traumatic brain and extremities injury. Read More

Urologiia 2022 Mar(1):67-71

Bashkir State Medical University, Urological department, Ufa.

Introduction: Surgical treatment of benign prostatic hyperplasia (BPH) is influenced by a rapidly growing number of technologies.

Aim: To determine the surgical potential of holmium laser enucleation of the prostate (HoLEP) and the rate of postoperative complications during the learning curve.

Materials And Methods: A total of 98 patients undergoing HoLEP in the surgical department of the Clinical Hospital "Mother & Child" during the period from January 2018 to May 2020 were included in the study. Read More

Int Urogynecol J 2022 Mar 7. Epub 2022 Mar 7.

Urology Department, Moscow State University of Medicine and Dentistry, Vuchetich str. 21/2, Moscow, Russian Federation, 127206.

Introduction And Hypothesis: Studies on non-obstetric urogenital fistulas (NOUGFs) provide limited information on predictive outcome factors. This study was aimed at specifying and analyzing the risk factors for long-term anatomical and functional results.

Methods: A cross-sectional study of surgical repair for non-obstetric urogenital fistula was performed. Read More

Injury 2022 Feb 2. Epub 2022 Feb 2.

Department of Pelvic and Acetabular Surgery, Southmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, United Kingdom.

Background: A consecutive series of 177 male patients, with high energy pelvic ring injuries, were treated operatively in our institution. The purpose of this study was to evaluate long-term sexual and urological dysfunction in these patients using validated disease specific patient reported outcome measures (PROMs), and identify if sexual and urological dysfunction is detectable from generic outcome scores used in the assessment of pelvic ring injury at a minimum of 10 years follow-up (range 10-22).

Methods: Surviving patients were contacted to complete validated PROMs to examine genitourinary and global functional outcome. Read More

Low Urin Tract Symptoms 2022 May 1;14(3):132-139. Epub 2022 Mar 1.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.

Neurogenic lower urinary tract dysfunction (NLUTD) caused by spinal cord injury (SCI) is challenging for urologists. NLUTD not only affects the quality of life but also endangers the upper urinary tract of patients with chronic SCI. Considering that the bladder and urethral function change with time, regular follow-up of NLUTD is necessary, and any complication should be adequately treated. Read More

Zhonghua Shao Shang Za Zhi 2022 Feb;38(2):170-183

School of Medicine, Nankai University, Tianjin 300071, China Research Center for Wound Repair and Tissue Regeneration, Medical Innovation Research Department, the PLA General Hospital, Beijing 100853, China.

To establish a high glucose senescent model of human dermal fibroblasts (HDFs), and to investigate the effects of exosomes derived from human decidua mesenchymal stem cells (dMSCs) on the proliferation, migration, and apoptosis of senescent HDFs and possible mechanism. The experimental research method was used. From January to March 2021, discarded foreskin tissue was collected for isolation and culture of primary HDFs from 4 male phimosis patients (aged 18-22 years) admitted for circumcision in the Fourth Medical Center of the PLA General Hospital. Read More

Medicine (Baltimore) 2022 Feb;101(8):e28955

Department of Obstectrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Rationale: Spontaneous complete uterine rupture during gestation is rare and has no specific symptoms; however, it is a life-threatening event for both the fetus and mother. The rupture typically happens in labor and is uncommon before labor. Herein, we present the case of a woman, encountering complete rupture at third trimester followed by laparoscopic cornuostomy. Read More

Spinal Cord 2022 May 23;60(5):408-413. Epub 2022 Feb 23.

University of British Columbia, Vancouver, BC, Canada.

Study Design: Retrospective anonymized cohort study.

Objectives: To study X-ray images of video urodynamics (VUD) in patients with spinal cord injury (SCI).

Setting: Single-center study. Read More

Int J Infect Dis 2022 Apr 17;117:302-311. Epub 2022 Feb 17.

Department of Clinical Laboratory, University of Tokyo Hospital, Tokyo, Japan; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Acute renal injury is an important complication of coronavirus disease 2019 (COVID-19). Both COVID-19-specific mechanisms, such as damage to the renal parenchyma by direct infection, and non-specific mechanisms, such as the pre-renal injury factors, have been proposed to be involved in COVID-19-associated renal injuries. In this study, we aimed to elucidate the characteristics of COVID-19-associated renal injuries, focusing mainly on urine sediment findings. Read More

Ultrastruct Pathol 2022 Jan 8;46(1):110-121. Epub 2022 Feb 8.

Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assuit, Egypt.

Ischemia-reperfusion injury is related to kidney dysfunction due to bilateral lower limb ischemia. This kidney injury may lead to acute kidney failure and mortality. Alpha-Lipoic Acid, a known antioxidant, can ameliorate kidney dysfunction and histopathology related to several etiologies. Read More

BMJ Case Rep 2022 Feb 7;15(2). Epub 2022 Feb 7.

Department of Surgery, Division of Surgical Transplantation, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Arterial injury leading to vascular occlusion is a rare complication of kidney transplantation that requires urgent intervention to salvage the kidney and prevent graft loss. Occasionally, the recipient iliac vessels may be injured, resulting in acute ischaemia of the lower extremity in addition to loss of blood flow to the kidney transplant. In the case presented here, a 58-year-old man with chronic kidney disease secondary to IgA nephropathy underwent pre-emptive deceased donor renal transplantation complicated by an external iliac artery (EIA) dissection proximal to the transplant anastomosis. Read More

J Urol 2022 Apr 21;207(4):754-768. Epub 2022 Jan 21.

Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Purpose: resection for bladder tumors has been developed to overcome shortcomings of conventional transurethral resection of bladder tumors with regard to safety, pathological evaluation and oncologic outcomes. However, the potential benefits and utility compared to conventional transurethral resection of bladder tumors have not been conclusively demonstrated. We aimed to update the current evidence with focus on the pathological benefits of resection for nonmuscle-invasive bladder cancer. Read More

Acta Biomater 2022 03 13;141:280-289. Epub 2022 Jan 13.

Michigan State University, Department of Mechanical Engineering, 428 S. Shaw Lane, Rm 2555, East Lansing, MI 48824, United States. Electronic address:

The ability of the urinary bladder to maintain low intravesical pressures while storing urine is key in ensuring proper organ function and highlights the key role that tissue mechanics plays in the lower urinary tract. Loss of supraspinal neuronal connections to the bladder after spinal cord injury can lead to remodeling of the structure of the bladder wall, which may alter its mechanical characteristics. In this study, we investigate if the morphology and mechanical properties of the bladder extracellular matrix are altered in rats 16 weeks after spinal cord injury as compared to animals who underwent sham surgery. Read More

World J Urol 2022 Apr 14;40(4):1035-1041. Epub 2022 Jan 14.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Purpose: Severe haemorrhage in percutaneous nephrolithotomy (PCNL) is an alarming event, and preventing injury to renal major vessels is a challenge. We evaluated the efficiency of a blunt needle in renal puncture procedures.

Methods: We first retrospectively reviewed the embolization images of post-PCNL patients to analyse the types of arteries injured, which were considered target arteries. Read More

Injury 2022 Mar 5;53(3):919-924. Epub 2022 Jan 5.

Penn State College of Medicine, Hershey, PA, 17033 USA; Department of Orthopaedics and Rehabilitation, Penn State Hershey Medical Center, Hershey, PA, 17033 USA.

Introduction: This study aimed to: (1) evaluate the independent risk factors related to survival and mortality and (2) predict survival in geriatric orthopaedic trauma patients admitted to our institution's ICU as a Level 1 or 2 trauma activation.

Methods: A retrospective review was performed on patients age >60, over a 10 year period, who were involved in a multi-trauma with orthopaedic injuries. Variables evaluated include: sex, age, Injury Severity Score (ISS), mechanism of injury, number and type of orthopaedic injury, anticoagulant use, comorbidities, length of stay in intensive care unit (ICU), type of ICU, ventilator use, vasopressors use, incidence of multiple organ dysfunction syndrome (MODS), number of surgeries, and 1-month and 6-month mortality. Read More

Int J Mol Sci 2021 Dec 24;23(1). Epub 2021 Dec 24.

Department of Nephrology, Hypertension and Internal Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, Poland.

Excessive consumption of fructose (FR) leads to obesity, metabolic syndrome (MS) and insulin resistance, which are known risk factors for kidney stones. The epidemiological study has suggested the association between fructose consumption and urolithiasis, but the precise mechanism is still not well understood. Male Wistar rats were assigned for 8 weeks to three groups with different FR content in diet: RD ( = 5)-regular diet with a FR < 3%; F10 ( = 6)-regular diet with an addition of 10% Fr in drinking water; F60 ( = 5)-60% FR as a solid food. Read More

Mil Med Res 2022 01 4;9(1). Epub 2022 Jan 4.

Department of Urology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, 34684, Turkey.

Background: After renal trauma, surgical treatment is vital, but sometimes there may be loss of function due to fibrosis. This study aimed to evaluate the effect of autologous omentum flaps on injured renal tissues in a rat model.

Methods: A total of 30 Wistar albino rats were included and randomly divided equally into a control group and four intervention groups. Read More

PLoS One 2022 4;17(1):e0262307. Epub 2022 Jan 4.

IFM Biology, Linköping University, Linköping, Sweden.

Every year, billions of egg layer chicks around the world are hatched under highly stressful, industrial circumstances. Here, it is investigated how the stressful procedure in the commercial hatchery, including incubation, hatching, processing, and transport affects the chicks with regards to traits relevant for the egg production industry. These traits were compared to those of a control group hatched in a small incubator and handled gently och quietly in a quiet room without any processing and transport. Read More

J Urol 2022 05 4;207(5):1077-1085. Epub 2022 Jan 4.

Department of Urology, University of California San Francisco, San Francisco, California.

Purpose: We evaluated angioembolization (AE) use for high-grade renal trauma (HGRT) management and compared AE vs surgical repair (SR) in requiring nephrectomy.

Materials And Methods: Using National Trauma Data Bank® 2013-2018, we identified patients with HGRT who underwent AE or SR as initial management. Therapy failure was defined as performing subsequent nephrectomy, partial nephrectomy, SR or AE. Read More

J Pediatr Orthop B 2021 Dec 22. Epub 2021 Dec 22.

Case Western Reserve University School of Medicine Case Western Reserve University Center for Clinical Informatics Research and Education, The MetroHealth System Division of Pediatric Orthopaedic Surgery, Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Objectives: Despite a high prevalence in the pediatric trauma population, there remains a lack of large population-based epidemiological studies on pediatric pelvic fractures. Using a de-identified national clinical registry, we investigated the epidemiological features of pediatric pelvic fractures.

Methods: We performed a retrospective analysis of data obtained from the IBM Watson Health Explorys Platform (Armonk, NY). Read More