1,398 results match your criteria Transthoracic Needle Biopsy

Analysis of Physicians' Probability Estimates of a Medical Outcome Based on a Sequence of Events.

JAMA Netw Open 2022 Jun 1;5(6):e2218804. Epub 2022 Jun 1.

Coventry, Connecticut.

Importance: The probability of a conjunction of 2 independent events is the product of the probabilities of the 2 components and therefore cannot exceed the probability of either component; violation of this basic law is called the conjunction fallacy. A common medical decision-making scenario involves estimating the probability of a final outcome resulting from a sequence of independent events; however, little is known about physicians' ability to accurately estimate the overall probability of success in these situations.

Objective: To ascertain whether physicians are able to correctly estimate the overall probability of a medical outcome resulting from 2 independent events. Read More

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Complications After Transthoracic Needle Biopsy of Pulmonary Nodules: A Population-Level Retrospective Cohort Analysis.

J Am Coll Radiol 2022 Jun 20. Epub 2022 Jun 20.

Senior Director, Lung Cancer Initiative, Johnson & Johnson Enterprise Innovation, New Brunswick, New Jersey.

Objective: To provide recent population-based estimates of transthoracic needle biopsy (TTNB) complications and risk factors associated with these complications.

Methods: This retrospective cohort analysis included adults from a nationally representative longitudinal insurance claims data set who underwent TTNB in 2017 or 2018. Complications that were evaluated included pneumothorax, hemorrhage, and air embolism. Read More

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Percutaneous Image-Guided Biopsy for a Comprehensive Hybridization Capture-Based Next-Generation Sequencing in Primary Lung Cancer: Safety, Efficacy, and Predictors of Outcome.

JTO Clin Res Rep 2022 Jun 18;3(6):100342. Epub 2022 May 18.

Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

Introduction: To evaluate factors associated with successful comprehensive genomic sequencing of image-guided percutaneous needle biopsies in patients with lung cancer using a broad hybrid capture-based next-generation sequencing assay (CHCA).

Methods: We conducted a single-institution retrospective review of image-guided percutaneous transthoracic needle biopsies from January 2018 to December 2019. Samples with confirmed diagnosis of primary lung cancer and for which CHCA had been attempted were identified. Read More

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Correlation of PD-L1 expression on tumour cells between diagnostic biopsies and surgical specimens of lung cancer in real life with respect to biopsy techniques and neoadjuvant treatment.

J Cancer Res Clin Oncol 2022 Jun 16. Epub 2022 Jun 16.

Department of Thoracic Surgery, Medical University Vienna, Vienna, Austria.

Purposes: Programmed death-ligand 1 (PD-L1) testing is performed mainly on biopsy specimens in patients with advanced lung cancer. It is questionable whether the small amount of tissue analysed in biopsies may represent the true PD-L1 expression of a tumour.

Methods: In this retrospective study, PD-L1 expression on tumour cells derived from bronchoscopy brush cytology, endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA), endobronchial biopsy, transbronchial biopsy (TBB) and computed tomography (CT)-guided transthoracic biopsy was compared to the PD-L1 expression of the corresponding surgical resection in lung cancer patients with regard to neoadjuvant treatment in-between. Read More

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Developing lung cancer in COPD: Possible role of carrying Alpha-1 antitrypsin deficiency variants.

Respir Med Case Rep 2022 21;38:101667. Epub 2022 May 21.

Department of Chest Diseases, Health Sciences University, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and airway inflammation, with a prevalence of 10.1%. Among the many causes of COPD, Smoking is the leading and another big cause is (AATD α1-antitrypsin deficiency)' an inherited disorder. Read More

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Lung Biopsy as Rare Cause of Thromboembolic Stroke: A Case Report.

Am J Case Rep 2022 May 29;23:e935587. Epub 2022 May 29.

Department of Interventional Radiology, Pueblo Radiology, Santa Barbara, CA, USA.

BACKGROUND CT-guided lung biopsy is a routine procedure used to evaluate suspicious pulmonary lesions that may arise from malignancy or infectious etiology. Common complications such as pneumothorax, bleeding, and rare cases of air embolisms leading to stroke have been documented as well. It is reported that there is a 0. Read More

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Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery.

J Vis Exp 2022 05 4(183). Epub 2022 May 4.

Section of Interventional Pulmonology, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill;

The increased use of chest computed tomography (CT) has led to an increased detection of pulmonary nodules requiring diagnostic evaluation and/or excision. Many of these nodules are identified and excised via minimally invasive thoracic surgery; however, subcentimeter and subsolid nodules are frequently difficult to identify intra-operatively. This can be mitigated by the use of electromagnetic transthoracic needle localization. Read More

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Early detection of delayed pneumothorax using lung ultrasound after transthoracic needle lung biopsy: A prospective pilot study.

Clin Respir J 2022 May 20;16(5):413-419. Epub 2022 May 20.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.

Objectives: Delayed pneumothorax can cause an emergency room visit and be life-threatening in case of tension pneumothorax after transthoracic needle biopsy. We hypothesized that most delayed pneumothoraces are diagnosed by later enlargement of occult pneumothorax due to the low diagnostic accuracy of a chest X-ray. Lung ultrasound is a highly accurate tool for detection of pneumothorax. Read More

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[Clinical efficacy of ct-guided transthoracic needle biopsy of peripheral lung lesions].

Khirurgiia (Mosk) 2022 (5):34-42

Moscow City Oncology Hospital No. 1, Moscow, Russia.

Objective: To evaluate the effectiveness of a step-by-step protocol for GT-guided transthoracic biopsy in verification of peripheral lung tumors.

Material And Methods: A retrospective analysis of the results of GT-guided transthoracic biopsies of focal lung neoplasms was performed between October 2019 and December 2020. The analysis included the results of 176 biopsies in 158 patients. Read More

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An initial experience of computed tomography-guided trans superior vena caval biopsy: a novel approach for precarious mediastinal lesions.

Pol J Radiol 2022 25;87:e233-e237. Epub 2022 Apr 25.

Department of Medical Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India.

Purpose: As interventional radiologists, we encounter precarious deep-seated mediastinal lesions in our day-to-day practice. The conventional technique of percutaneous transthoracic biopsy of these lesions carries significant intrinsic complications. Endovascular approaches for such lesions under fluoroscopic guidance have been described in previous literature but with significant technical constraints. Read More

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Polymyositis as a paraneoplastic syndrome of a patient with primary pulmonary lymphoepithelioma-like carcinoma: a case report and literature review.

J Cardiothorac Surg 2022 May 17;17(1):120. Epub 2022 May 17.

Department of Cardiothoracic Surgery, The First People's Hospital of Neijiang, Shizhong District, No. 1866, West Section of Hanan Avenue, Neijiang, 641000, Sichuan, China.

Background: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer, which mostly occurred in non-smoking Asian populations. The prognosis of this tumor is better than other lung cancers. Polymyositis, a kind of idiopathic inflammatory myopathies, may negatively affect the prognosis of patients with lung cancer as a paraneoplastic syndrome (PNPS). Read More

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Marked safety and high diagnostic yield of freehand ultrasound-guided core-needle biopsies performed by pulmonologists.

Thorac Cancer 2022 Jun 26;13(11):1577-1582. Epub 2022 Apr 26.

Pulmonary Division, Rabin Medical Center, Petah Tikva, Israel.

Background: Adequate tissue sampling is fundamental for establishing a definitive diagnosis, assessing prognosis and tailoring therapy. Each of the methods for obtaining tissue (e.g. Read More

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Three-dimensionally printed navigational template: a promising guiding approach for lung biopsy.

Transl Lung Cancer Res 2022 Mar;11(3):393-403

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Percutaneous transthoracic lung biopsy is customarily conducted under computed tomography (CT) guidance, which primarily depends on the conductors' experience and inevitably contributes to long procedural duration and radiation exposure. Novel technique facilitating lung biopsy is currently demanded.

Methods: Based on the reconstructed anatomical information of CT scans, a three-dimensionally printed navigational template was customized to guide fine-needle aspiration (FNA). Read More

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Utility and safety of sole electromagnetic navigation bronchoscopy under moderate sedation for lung cancer diagnosis.

Transl Lung Cancer Res 2022 Mar;11(3):462-471

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: Electromagnetic navigation bronchoscopy (ENB) is an emerging technique for diagnosing pulmonary lesions. However, limited data is available on its sole utility under a least invasive setting without general anesthesia. We aimed to evaluate the diagnostic performance and safety of sole ENB under moderate sedation for diagnosing pulmonary lesions suspicious for lung cancer and to determine clinical factors associated with a better diagnostic yield. Read More

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Risk factors for pneumothorax and pulmonary hemorrhage following computed tomography-guided transthoracic core-needle biopsy of subpleural lung lesions.

J Chin Med Assoc 2022 04;85(4):500-506

Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Identifying the risk factors for complications may alert the physicians and help them adjust their plans before performing computed tomography-guided lung biopsies. Reportedly, a pleura-nodule distance longer than 2.0 cm is a strong predictor for pneumothorax and pulmonary hemorrhage. Read More

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Magnetic resonance-guided repeat biopsy of suspicious malignant lung lesions after an initial negative computed tomography-guided Biopsy.

J Cancer Res Ther 2021 Dec;17(7):1689-1695

Department of Imaging Interventional Therapy, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University; Department of Imaging Interventional Therapy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China.

Objective: This study sought to establish the diagnostic utility of performing a second biopsy using an magnetic resonance (MR)-guided percutaneous transthoracic needle biopsy (PTNB) approach in patients with suspicious malignant lung lesions that had already undergone an initial negative computed tomography (CT)-guided biopsy.

Materials And Methods: This study evaluated 31 patients with suspicious lung lesions (18 males, 13 females; mean age: 62.1 ± 11. Read More

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December 2021

Diagnostic efficiency and safety of rapid on-site evaluation combined with CT-guided transthoracic core needle biopsy in suspected lung cancer patients.

Cytopathology 2022 Jul 10;33(4):439-444. Epub 2022 May 10.

Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Objective: The efficacy of rapid on-site evaluation (ROSE) combined with computed tomography-guided transthoracic core needle biopsy (CT-guided TCNB) is rarely investigated. This study aimed to evaluate the diagnostic efficiency and safety of ROSE combined with CT-guided TCNB for suspected lung cancer patients.

Materials And Methods: Clinical data from 285 patients who received CT-guided TCNB for suspected lung cancer in Huashan Hospital from 2015 to 2018 were retrospectively analysed. Read More

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[Recent advances in diagnosis of pulmonary nodule].

J W Liu X N Zhang

Zhonghua Wai Ke Za Zhi 2022 May;60(5):498-503

Department of Thoracic Surgery, Peking University First Hospital, Beijing 100034, China.

With the popularization of health screening and the widespread use of low-dose computed tomography, the detection rate of lung nodules has increased year after year. However, the false positive rates testified by surgery of these lung nodules are still high. Therefore, it is vital in clinical practice to avoid overtreatment or undertreatment. Read More

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Robotic Navigational Bronchoscopy Combined with Needle-Based Confocal Laser Endomicroscopy: Case Report of a Novel Approach to Diagnose Small Lung Nodules.

Respiration 2022 29;101(5):494-499. Epub 2022 Mar 29.

Department of Respiratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death. Advancements in navigational bronchoscopy have shown encouraging results but the diagnostic yield of small lung nodules by bronchoscopic techniques is still below that of transthoracic needle aspiration. The development of robotic bronchoscopy has demonstrated a significantly improved navigational success but the diagnostic yield is regularly limited by near-miss of the target nodule. Read More

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A case series of pulmonary alveolar proteinosis: Response differently to whole lung lavage.

Med J Malaysia 2022 03;77(2):261-263

Pusat Perubatan Universiti Kebangsaan Malaysia, Department of Internal Medicine, Respiratory Unit, Malaysia.

Pulmonary alveolar proteinosis (PAP) is a rare disease and its prognosis can be improved by whole lung lavage (WLL). Herein, we present three cases with idiopathic PAP treated successfully with either single or double WLL in the same setting. All three of them presented with exertional dyspnoea with radiographic findings of pulmonary infiltrates. Read More

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Port J Card Thorac Vasc Surg 2022 Jan 4;28(4):43-46. Epub 2022 Jan 4.

Radiology Department, CHVNGE - Vila Nova de Gaia, Portugal.

Introduction: Transthoracic biopsies under fluoro-computer tomography (CT) guidance play an important role on the diagnosis and management of lung nodules, permitting histological examination and differentiation between benign and malignant lesions(1). Furthermore, with recent advances in target therapy, it is increasingly necessary to obtain tumor tissue for the analysis of molecular fingerprints allowing personalized treatment(1). Although many studies report low complication rates for this procedure, they are not negligible, urging the need for a structured and reproducible guide to reduce technique-related complications(1,2). Read More

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January 2022

Is Free Breathing Possible During Computed Tomography-Guided Percutaneous Transthoracic Lung Biopsy? The Clinical Experience in 585 Cases.

J Comput Assist Tomogr 2022 Mar-Apr 01;46(2):294-299

From the Department of Radiology, Inje University Busan Paik Hospital.

Objective: The aim of the study was to retrospectively evaluate the safety and accuracy of computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) of lung lesions during quiet breathing.

Methods: We investigated the diagnostic performance and complication rate of 585 procedures in 563 patients (357 men; mean age, 67.7 years), who underwent CT-guided PTNBs during quiet breathing, aided by a respiratory targeting technique from May 2017 to July 2019. Read More

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Amiodarone-Induced Multi-Systemic Toxicity Involving the Liver, Lungs, Thyroid, and Eyes: A Case Report.

Front Cardiovasc Med 2022 28;9:839441. Epub 2022 Feb 28.

Department of Gastroenterology and Hepatology, Chonnam National University Hospital and Medical School, Gwangju, South Korea.

Objectives: Amiodarone is widely used to treat arrhythmia. However, amiodarone is known for its severe toxicity to the liver, lungs, and thyroid. Amiodarone causes liver damage ranging from asymptomatic serum aminotransferase elevation to hepatic failure requiring liver transplantation. Read More

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February 2022

Imaging-guided percutaneous transthoracic needle biopsy of nodules in the lung base: fluoroscopy CT versus cone-beam CT.

Clin Radiol 2022 05 25;77(5):e394-e399. Epub 2022 Feb 25.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. Electronic address:

Aim: To compare the diagnostic performance and safety of fluoroscopy computed tomography (FCT)-guided to cone-beam CT (CBCT)-guided percutaneous transthoracic needle biopsy (PTNB) in patients with nodules in the lung base.

Materials And Methods: The clinical data of 379 patients (228 in the FCT group and 151 in the CBCT group) with nodules in the lung base who underwent FCT-guided or CBCT-guided PTNB from September 2009 to March 2020 were analysed retrospectively. Study outcomes included patient demographics, nodule characteristics, technical success, pathological diagnosis, complications, and radiation exposure. Read More

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CT-Guided Transthoracic Biopsy of Pulmonary Lesions: Diagnostic versus Nondiagnostic Results.

Diagnostics (Basel) 2022 Jan 31;12(2). Epub 2022 Jan 31.

Unit of Interventional and Diagnostic Ultrasound of Internal Medicine, IRCCS Fondazione Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, FG, Italy.

(1) Background: Despite the high accuracy of CT-guided transthoracic biopsy for diagnosis of pulmonary lesions, in a certain amount of cases biopsy results may indicate the presence of nonspecific findings or insufficient material. We aimed to investigate the effectiveness of CT-guided transthoracic biopsy of pulmonary lesions in providing a specific diagnosis and to analyze the variables affecting biopsy results. (2) Methods: In this retrospective study, a total of 170 patients undergoing 183 CT-guided transthoracic biopsies of pulmonary lesions were included. Read More

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January 2022

Application of Electromagnetic Navigation Bronchoscopy in the early diagnosis and treatment of lung cancer: a narrative review.

Transl Cancer Res 2021 Mar;10(3):1583-1593

Department of Pulmonary Medicine, Xijing Hospital, Air Force Medical University, Xi'an, China.

The diagnosis of lung cancer has long been a problem facing clinicians worldwide, and the emergence of electromagnetic navigation bronchoscopy (ENB) has played a critical role in the early diagnosis of lung cancer. Compared with other types of biopsy techniques (e.g. Read More

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Deep Learning for Detecting Pneumothorax on Chest Radiographs after Needle Biopsy: Clinical Implementation.

Radiology 2022 05 25;303(2):433-441. Epub 2022 Jan 25.

From the Department of Radiology, Seoul National University Hospital, Seoul, Korea (W.H., E.J.H., J.H.L., J.P., J.M.G., C.M.P.); Institute of Radiation Medicine, Seoul National University Medical Research Center, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea (E.J.H., J.M.G., C.M.P.); and Cancer Research Institute, Seoul National University, Seoul, Korea (J.M.G., C.M.P.).

Background Accurate detection of pneumothorax on chest radiographs, the most common complication of percutaneous transthoracic needle biopsies (PTNBs), is not always easy in practice. A computer-aided detection (CAD) system may help detect pneumothorax. Purpose To investigate whether a deep learning-based CAD system can improve detection performance for pneumothorax on chest radiographs after PTNB in clinical practice. Read More

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C-Arm Cone-Beam CT Virtual Navigation versus Conventional CT Guidance in the Transthoracic Lung Biopsy: A Case-Control Study.

Diagnostics (Basel) 2022 Jan 5;12(1). Epub 2022 Jan 5.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan 430022, China.

C-arm cone-beam computed tomography (CBCT) virtual navigation-guided lung biopsy has been developed in the last decade as an alternative to conventional CT-guided lung biopsy. This study aims to compare the biopsy accuracy and safety between these two techniques and explores the risk factors of biopsy-related complications. A total of 217 consecutive patients undergoing conventional CT- or C-arm CBCT virtual navigation-guided lung biopsy from 1 June 2018 to 31 December 2019 in this single-center were retrospectively reviewed. Read More

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January 2022

18F-FDG PET/CT Findings in a Patient With Primary Primitive Neuroectodermal Tumor of the Lung.

Clin Nucl Med 2022 Apr;47(4):326-328

Respiration, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.

Abstract: Primary primitive neuroectodermal tumor of the lung is an extremely rare and highly malignant neoplasm with a poor prognosis. A 49-year-old man presented with a dry cough and slight pain in the left chest for nearly 1 month. 18F-FDG PET/CT showed intense 18F-FDG uptake of the left inferior lung tumor and hypermetabolic mediastinal lymph nodes. Read More

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Evaluating the Patient With a Pulmonary Nodule: A Review.

JAMA 2022 Jan;327(3):264-273

Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.

Importance: Pulmonary nodules are identified in approximately 1.6 million patients per year in the US and are detected on approximately 30% of computed tomographic (CT) images of the chest. Optimal treatment of an individual with a pulmonary nodule can lead to early detection of cancer while minimizing testing for a benign nodule. Read More

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January 2022