24,349 results match your criteria Transposition Flaps
JMIR Public Health Surveill 2018 Dec 13;4(4):e10436. Epub 2018 Dec 13.
Division of Global HIV and TB, Centers for Disease Control and Prevention, Nairobi, Kenya.
Background: A universal health care identifier (UHID) facilitates the development of longitudinal medical records in health care settings where follow up and tracking of persons across health care sectors are needed. HIV case-based surveillance (CBS) entails longitudinal follow up of HIV cases from diagnosis, linkage to care and treatment, and is recommended for second generation HIV surveillance. In the absence of a UHID, records matching, linking, and deduplication may be done using score-based persons matching algorithms. Read More
A A Pract 2018 Dec 7. Epub 2018 Dec 7.
From the Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Myocardial ischemia postarterial switch operation has been reported extensively in the literature and has been almost exclusively ascribed to issues related to coronary artery translocation. Here, we report a case of a 5-week-old child with D-transposition of the great arteries who underwent an arterial switch operation and developed myocardial ischemia after pericardial drain placement, as evidenced by significant ST segment elevation and abnormal regional cardiac wall motion. The ST segment and cardiac wall motion improved once the drain was withdrawn from the pericardium and placed in the retrosternal space. Read More
Methods Mol Biol 2019 ;1907:161-170
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Transposable elements are DNA sequences with the ability to move from one genomic location to another. The movement of class II transposable elements has been functionally harnessed and separated into two distinct DNA transposon components: the terminal inverted repeat sequences that flank genetic cargo to be mobilized and a transposase enzyme capable of recognizing the terminal inverted repeat sequences and catalyzing the transposition reaction. In particular, the Sleeping Beauty (SB) system was the first successful demonstration of transposon-based gene transfer in vertebrate species. Read More
J Anat 2018 Dec 7. Epub 2018 Dec 7.
Paediatric Cardiology, Centre de Référence Malformations Cardiaques Congénitales Complexes - M3C, Necker Hospital for Sick Children, Assistance Publique des Hôpitaux de Paris, Paris, France.
The aim of this study was to analyse the anatomy of the ventricular septal defect (VSD) in heart specimens with interruption of the aortic arch (IAA) in order to explore the hypothesis of different embryologic mechanisms for the different anatomic types of IAA. We examined 42 human heart specimens, 25 with IAA as the main disease with concordant atrioventricular and ventriculo-arterial connections and two distinct great arteries, and 17 hearts with IAA associated with other malformations [six common arterial trunk (CAT), five double-outlet right ventricle (DORV), three transposition of the great arteries (TGA), three atrioventricular septal defect (AVSD)]. The interruption was classified according to Celoria and Patton. Read More
Neural Regen Res 2019 Mar;14(3):519-524
Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.
For severe cubital tunnel syndrome, patients with absent sensory nerve action potential tend to have more severe nerve damage than those without. Thus, it is speculated that such patients generally have a poor prognosis. How absent sensory nerve action potential affects surgical outcomes remains uncertain owing to a scarcity of reports and conflicting results. Read More
J Cardiol Cases 2014 Jul 17;10(1):39-41. Epub 2014 May 17.
Department of Cardiology, Aichi Children's Health and Medical Center, Obu, Japan.
We report performing a successful arterial switch operation on a full-term male infant with transposition of the great arteries and intact ventricular septum associated with a congenital diaphragmatic hernia. The patient developed severe persistent pulmonary hypertension after successful repair of a left congenital diaphragmatic hernia that restricted pulmonary blood flow into the hypoplastic left lung, and subsequent unilateral pulmonary congestion of the unaffected right lung occurred because of the hemodynamics generated by the transposition of the great arteries. Intravenous epoprostenol with nitric oxide inhalation and mechanical hypoventilation effectively controlled pulmonary vascular resistance before the arterial switch operation was performed. Read More
J Cardiol Cases 2012 Aug 2;6(2):e39-e41. Epub 2012 May 2.
Rize University Medical Faculty, Department of Cardiovascular Surgery, Rize, Turkey.
Single coronary artery (SCA) is a rare congenital anomaly in which the entire coronary system arises from a solitary ostium. Although an uncommon congenital anomaly, SCA is encountered more frequently in the presence of other congenital cardiac malformations such as persistent truncus arteriosus, tetralogy of Fallot, transposition of the great arteries, or pulmonary atresia. In this report, we present a case of SCA arising from the left sinus of valsalva coexisting with perimembranous ventricular septal defect. Read More
J Cardiol Cases 2011 Feb 1;3(1):e50-e52. Epub 2011 Feb 1.
Department of Cardiology, Hacettepe University, Ankara, Turkey.
We report on a 32-year-old woman who had Mustard operation for transposition of great arteries and who underwent successful pregnancy by in vitro fertilization and without peripartum complications. Read More
Eur Heart J Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.
The Intervention Centre, Oslo University Hospital, Rikshospitalet, Sognsvannsvn 20, Oslo, Norway.
Aims: Proof of concept and feasibility study for preoperative diagnostic use of mixed reality (MR) holograms of individual 3D heart models from standard cardiac computed tomography angiograms (CTA) images. Optimal repair for complex congenital heart disease poses high demands on 3D anatomical imagination. Three-dimensional printed heart models are increasingly used for improved morphological understanding during surgical and interventional planning. Read More
Plast Reconstr Surg Glob Open 2018 Oct 4;6(10):e1962. Epub 2018 Oct 4.
Division of Plastic Surgery, Nara Medical University Hospital, Nara, Japan.
We report a case, function preservation of the upper lip after tumor resection was possible using residual orbicularis oris muscle and attached levator labii superioris alaeque nasi. Patient was 67-year-old male with squamous cell carcinoma at the vermilion border. The tumor was resected with an 8-mm margin, leaving the oral mucosa as intact as possible. Read More
Oxid Med Cell Longev 2018 11;2018:7342451. Epub 2018 Nov 11.
Clinic of General, Visceral, Transplantation and Vascular Surgery, Hospital of the Ludwig Maximilian University, Munich, Germany.
Background: The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects.
Aims: To assess the effect of ileal transposition (IT) and sham types of bariatric procedures on the antioxidative systems in the liver tissue of Zucker rats (Crl:ZUC Lepr). Read More
Nat Plants 2018 Dec 10. Epub 2018 Dec 10.
The Sainsbury Laboratory, University of Cambridge, Cambridge, UK.
Retrotransposons have played an important role in the evolution of host genomes. Their impact is mainly deduced from the composition of DNA sequences that have been fixed over evolutionary time. Such studies provide important 'snapshots' reflecting the historical activities of transposons but do not predict current transposition potential. Read More
Dis Colon Rectum 2019 Jan;62(1):104-111
Department of Surgical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Background: Severe fecal incontinence has a significant negative impact on patient well-being. Current surgical methods of total anorectal reconstruction to substitute a colostomy have suboptimal results. A composite graft using antropyloric valve transposition and gracilis wrap has been described with good outcomes. Read More
Arch Dis Child Educ Pract Ed 2018 Dec 8. Epub 2018 Dec 8.
Paediatrics, Leeds General Infirmary, Leeds, UK.
Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.
Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
New Delhi metallo-beta-lactamases (NDMs) are an uncommon but emerging cause of carbapenem resistance in the United States. Genomic factors promoting their domestic spread remain poorly characterized. A prospective genomic surveillance program among Boston-area hospitals identified multiple new occurrences of NDM carrying strains of and complex in inpatient and outpatient settings, representing the first occurrences of NDM-mediated resistance since initiating genomic surveillance in 2011. Read More
J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.
Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Background: Radial-cephalic arteriovenous fistula and brachial-cephalic arteriovenous fistula are the first and second choices for creating vascular access in dialysis patients as recommended by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative. Basilic vein transposition or use of a forearm (polytetrafluoroethylene [PTFE]) loop graft is recommended thereafter. The aim of this study was twofold: first, to compare the outcomes and patency rates of patients treated with a basilic vein transposition with those of patients treated with a PTFE loop; and second, to identify patient-related factors of influence on patency rates. Read More
Int J Cardiol 2018 Nov 22. Epub 2018 Nov 22.
Division of Radiology and Nuclear Medicine, Dept of Radiology, Rikshospitalet, Oslo University Hospital, Norway.
Radiologia 2018 Dec 4. Epub 2018 Dec 4.
Servicio de Radiología Pediátrica, Imagen Cardíaca Pediátrica y Cardiopatías Congénitas. Hospital La Paz, Madrid, España.
Congenitally corrected transposition of the great vessels implies double discordance: atrioventricular and ventriculoarterial. We present cardiac magnetic resonance images from a 9-year-old girl with congenitally corrected transposition of the great vessels, interventricular communication, and coarctation of the aorta who was treated with pulmonary artery banding, correction of coarctation, and posterior double switch. We also review the disease and the complications that should be evaluated after the surgical intervention. Read More
Can J Cardiol 2018 Dec 5;34(12):1618-1623. Epub 2018 Oct 5.
Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich, Technical University Munich, Munich, Germany; Institute of Preventive Pediatrics, Technical University Munich, Munich, Germany.
Background: With increased long-term survival, children with congenital heart disease (CHD) are at increased risk of early-onset adult cardiovascular disease. Carotid intima-media thickness (cIMT) is a surrogate marker of atherosclerosis. The aim of this present study was to detect high-risk diagnostic subgroups by measuring cIMT and determine its correlates in children with CHD and subgroups of CHD compared with healthy controls. Read More
Hum Gene Ther 2018 Dec 10. Epub 2018 Dec 10.
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders (Huazhong University of Science and Technology) , 1095# Jiefang Ave., Wuhan 430030, P.R. China , Wuhan, China , 430030 ;
Myostatin, a negative modulator of muscle growth, has been considered as a potential target for treatment of type 2 diabetes. In our previous work, we found that myostatin inhibition by adeno-associated virus (AAV) mediated gene delivery of myostatin propeptide (MPRO) could improve muscle mass and achieve therapeutic effects on glucose regulation and lipid metabolism in db/db mice. In this study, we investigated whether pre-intervention of rAAV-mediated expression of MPRO could lower the incidence of type 2 diabetes. Read More
Pacing Clin Electrophysiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Cardiothoracic Surgery, UCLA Medical Center, University of California Los Angeles, Los Angeles, California.
Background: Patients with systemic right ventricle (RV) often develop progressive heart failure and may benefit from cardiac resynchronization therapy (CRT); however, the optimal strategy for CRT has not been defined.
Methods: A retrospective review of all the patients with systemic RV failure undergoing a hybrid transcatheter-surgical approach was performed. Procedural technique and outcomes are reported. Read More
Mol Ecol 2018 Dec 5. Epub 2018 Dec 5.
Carl von Ossietzky University Oldenburg, Institute for Biology and Environmental Sciences, Carl von Ossietzky Str. 9-11, 26111, Oldenburg, Germany.
Hybridization can induce transposons to jump into new genomic positions, which may result in their accumulation across the genome. Alternatively, transposon copy numbers may increase through non-allelic (ectopic) homologous recombination in highly repetitive regions of the genome. The relative contribution of transposition bursts versus recombination-based mechanisms to evolutionary processes remains unclear because studies on transposon dynamics in natural systems are rare. Read More
Am J Case Rep 2018 Dec 6;19:1445-1448. Epub 2018 Dec 6.
Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
BACKGROUND Levo-transposition of the great arteries (L-TGA) is a rare form of congenital heart disease that may go unrecognized until adulthood. Parturient women with L-TGA have a high likelihood of developing acute pulmonary edema and cardiac dysrhythmias during the peri-partum period. CASE REPORT We present the case of a 32-year-old primigravida patient with previously unknown diagnosis of L-TGA, presenting with preeclampsia, whose peri-partum course was complicated by the development of acute pulmonary edema, complete heart block, and acute hypoxic respiratory failure. Read More
Plast Surg Nurs 2018 Oct/Dec;38(4):162-165
Enrique Salmerón-González, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Elena García-Vilariño, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Pedro A. Antolin-Santamaria, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Alberto Sanchez-Garcia, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Alfonso A. Valverde-Navarro, PhD, Director, Department of Human Anatomy and Embryology, University of Valencia, Spain.
In this article, we describe the case of a 59-year-old patient suffering from a squamous cell carcinoma affecting the upper third of the esophagus, treated with a cervical exenteration with extended resection of the posterior wall of the trachea, which was reconstructed with a gastric tube transposition and a myocutaneous pectoralis major flap for coverage of the gastropharyngeal anastomosis and stabilization of the posterior tracheal wall. Also, a review of literature regarding posterior tracheal wall reconstruction is performed. Read More
World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.
Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Fuxing Hospital, Capital Medical University, Beijing, China.
Objective: The repositioning of a dolichoectatic vertebrobasilar artery for arterial decompression has been extensively utilized in the clinical setting. This study aims to describe and summarize the technical characteristics and clinical results of the sling technique.
Methods: The terms "dolichoectatic aneurysm", "dolichoectasia", "ectasia" and "megadolichoectasia" were used to search for pertinent articles related to the VBA territory. Read More
Actas Dermosifiliogr 2018 Nov 28. Epub 2018 Nov 28.
Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, Navarra, España. Electronic address:
Eur J Prev Cardiol 2018 Nov 30:2047487318816508. Epub 2018 Nov 30.
2 Department of Pediatric Cardiology and Congenital Heart Disease, Technical University of Munich, Germany.
Background: The respiratory benefits of muscle strength are well-known in heart-healthy populations, but recommendations and research often focus instead on aerobic fitness (peak oxygen uptake) or total activity. Independent benefits of strength thus may be underestimated, especially in congenital heart disease where perceived dangers of certain types of exercise may outweigh perceived benefits. To assess whether it is plausible that pulmonary benefits of strength in heart-healthy populations also apply in congenital heart disease, we simultaneously correlated these patients' lung function with fitness, strength, and cardiac diagnosis. Read More
J Bone Joint Surg Am 2018 Dec;100(23):e148
Department of Orthopaedic Surgery (C.J.D. and C.A.G.), Division of Public Health Services, Department of Surgery (C.J.D.), and Division of General Medical Sciences (A.L.A. and J.M.D.), Washington University School of Medicine, St. Louis, Missouri.
Background: Overlapping surgery is attracting increased scrutiny. The American College of Surgeons states that the attending surgeon must be present for all critical portions of a surgical procedure; however, critical portions of surgical procedures are not defined. We hypothesized that a Delphi panel process would measure consensus on critical portions of 3 common hand surgical procedures. Read More
Am J Surg 2018 Nov 27. Epub 2018 Nov 27.
Section of Pediatric Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, 06520, USA. Electronic address:
The surgical management of intestinal failure secondary to short bowel syndrome has undergone tremendous evolution in the last several decades. From the landmark description of an intestinal lengthening procedure by Bianchi in 1980 to the multidisciplinary modern care paradigm known as intestinal rehabilitation, innovative new treatments in this field have vastly improved patient outcomes. Initial attempts to treat short bowel syndrome surgically saw the birth of reversed intestinal segments, artificial valves and colonic transposition, all aimed at decreasing transit time and thus increasing absorption. Read More
Phys Rev Lett 2018 Nov;121(20):200503
Department of Mathematical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Genuine high-dimensional entanglement, i.e., the property of having a high Schmidt number, constitutes an instrumental resource in quantum communication, overcoming limitations of low-dimensional systems. Read More
J Biomed Opt 2018 Nov;24(3):1-11
Space Engineering University, Beijing, China.
A clear image of an observed object may deteriorate into unrecognizable speckle when encountering heterogeneous scattering media, thus it is necessary to recover the object image from the speckle. A method combining least square and semidefinite programming is proposed, which can be used for imaging through scattering media. The proposed method consists of two main stages, that is, media scattering characteristics (SCs) estimation and image reconstruction. Read More
J Am Coll Cardiol 2018 Dec;72(22):2778-2788
Department of Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom.
Echocardiography is the mainstay in screening for pulmonary hypertension (PH). International guidelines suggest echocardiographic parameters for suspecting PH, but these may not apply to many adults with congenital heart disease (ACHD). PH is relatively common in ACHD patients and can significantly affect their exercise capacity, quality of life, and prognosis. Read More
J Neurosurg 2018 Nov 1:1-10. Epub 2018 Nov 1.
OBJECTIVEAlthough sphenoidotomy is more commonly performed via the transnasal approach than via the transcranial approach, transcranial sphenoidotomy (TCS) remains indispensable for en bloc resection of locally advanced sinonasal malignant tumors (SNMTs) extending to the skull base. TCS also enables transsphenoidal transposition of the temporoparietal galeal flap (TPGF) to compensate for the lack of vascularized reconstructive tissue after endoscopic transnasal skull base surgery. The objective of this study was to review the authors' surgical experience using TCS with an emphasis on the surgical anatomy of the sphenoid sinus and on the purpose of TCS. Read More
Mymensingh Med J 2018 Oct;27(4):872-878
Professor Dr Md Kamruzzaman Khan, Professor Department of Surgery, Dhaka Community Medical College and Hospital, Dhaka, Bangladesh.
Laparoscopic cholecystectomy has become the standard approach since its introduction in 1987 by Mouret. Situs inversus totalis is a rare anomaly in which transposition of the organ to the opposite site of the body occurs. Laparoscopic cholecystectomy due to gall stone disease in such few cases has been reported in the literature. Read More
Proc Natl Acad Sci U S A 2018 Dec 28;115(50):E11614-E11622. Epub 2018 Nov 28.
Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712
The Gam protein of transposable phage Mu is an ortholog of eukaryotic and bacterial Ku proteins, which carry out nonhomologous DNA end joining (NHEJ) with the help of dedicated ATP-dependent ligases. Many bacteria carry Gam homologs associated with either complete or defective Mu-like prophages, but the role of Gam in the life cycle of Mu or in bacteria is unknown. Here, we show that MuGam is part of a two-component bacterial NHEJ DNA repair system. Read More
Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.
Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia.
To review and discuss the uterine transposition technique for preserving fertility in patients who require pelvic radiotherapy. Uterine transposition was developed from adapting well-established surgical techniques with the goal of keeping the uterus and adnexa outside the radiotherapy field in order to preserve their function. The uterine transposition technique is presented step by step, with discussion of the literature that served as the basis for the technique's development. Read More
Int J Mol Sci 2018 Nov 27;19(12). Epub 2018 Nov 27.
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea.
Hybridization has been routinely practiced in agriculture to enhance the crop yield. Principally, it can cause hybrid vigor where hybrid plants display increased size, biomass, fertility, and resistance to diseases, when compared to their parents. During hybridization, hybrid offspring receive a genomic shock due to mixing of distant parental genomes, which triggers a myriad of genomic rearrangements, e. Read More
J Forensic Sci 2018 Nov 28. Epub 2018 Nov 28.
Eastern Virginia Medical School, Physician Assistant Program, 825 Fairfax Avenue, Norfolk, VA, 23507.
Transposition of the great vessels (TGV) is a common congenital heart defect that is difficult to diagnose before birth. Antenatal diagnosis is associated with increased survival. Unusual features such as anomalous pulmonary artery origin may delay cyanosis, decreasing clinical suspicion. Read More
Case Rep Neurol 2018 Sep-Dec;10(3):292-296. Epub 2018 Oct 9.
Department of Neurosurgery, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Republic of Korea.
A proximal occluded vertebral artery (VA) with reconstitution by muscular collateral vessels is a relatively common finding. However, due to inadequate intracranial anastomosis and hypoplasia or stenosis of the opposite VA, a number of patients develop symptoms of brain ischemia. In the current case, a 63-year-old man presented with repeat neurological symptoms such as dizziness, nausea, vomiting, dysarthria, left hemiparesis, and right hemianopsia. Read More
Ann Thorac Surg 2018 Nov 24. Epub 2018 Nov 24.
Department of Research.
Here, we report a case of 3 year girl with d-TGA with IVS managed by Damus-Kaye-Stansel with right bidirectional. cavopulmonary anastomosis in first stage to train LV followed by definitive surgery (arterial switch) in second stage. Read More
PeerJ 2018 14;6:e5914. Epub 2018 Nov 14.
College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang, China.
The owlflies (Family Ascalaphidae) belong to the Neuroptera but are often mistaken as dragonflies because of morphological characters. To date, only three mitochondrial genomes of Ascalaphidae, namely ; ; , are published in GenBank, meaning that they are greatly under-represented in comparison with the 430 described species reported in this family. In this study, we sequenced and described the complete mitochondrial genome of (Neuroptera, Ascalaphidae). Read More
Angew Chem Int Ed Engl 2018 Nov 26. Epub 2018 Nov 26.
Kyoto University, Department of Synth. Chem. & Biol. Chem., Katsura, 615-8510, Kyoto, JAPAN.
The stereoselective synthesis of anti-isomers of γ-boryl-substituted homoallylic alcohols is disclosed. (E)-1,2-Di(boryl)alk-1-enes undergo Ru-catalyzed double-bond transposition with control of the geometry. The in situ generated (E)-1,2-di(boryl)alk-2-enes add to aldehydes in a stereospecific manner. Read More
Circulation 2018 Nov;138(19):2119-2129
Division of Cardiology (M.L.O., A.C.G., M.J.G., Y.D., J.J.R.), The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania.
Background: The arterial switch operation (ASO) is the gold standard operative correction of neonates with transposition of the great arteries and intact ventricular septum, with excellent operative survival. The associations between patient and surgeon characteristics and outcomes are well understood, but the associations between variation in preoperative care and outcomes are less well studied.
Methods: A multicenter retrospective cohort study of infants undergoing neonatal ASO between January 2010 and September 2015 at hospitals contributing data to the Pediatric Health Information Systems database was performed. Read More
Drug Resist Updat 2018 Nov 2;41:26-39. Epub 2018 Nov 2.
School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia. Electronic address:
In multiply resistant Acinetobacter baumannii, complex transposons located in the chromosomal comM gene carry antibiotic and heavy metal resistance determinants. For one type, known collectively as AbaR, the ancestral form, AbaR0, entered a member of global clone 1 (GC1) in the mid 1970s and continued to evolve in situ forming many variants. In AbaR0, antibiotic and mercuric ion resistance genes are located between copies of a cadmium-zinc resistance transposon, Tn6018, and this composite transposon is in a class III transposon, Tn6019, carrying arsenate/arsenite resistance genes and five tni transposition genes. Read More
J Shoulder Elbow Surg 2018 Nov 21. Epub 2018 Nov 21.
Orthopaedic and Trauma Surgery Department, Cairo University, Cairo, Egypt. Electronic address:
Background: Late presentation of lateral condylar fractures of the humerus is not an uncommon problem in children, and to lesser extent, in adults. The various surgical interventions for repairing the fracture, correcting the deformity, or even performing anterior transposition of the ulnar nerve as a single procedure or in combination, especially in adults, is still a controversial topic, with a paucity of literature regarding this. There is a risk of loss of the available preoperative range of motion, nonunion, and avascular necrosis. Read More
Congenit Heart Dis 2018 Nov 23. Epub 2018 Nov 23.
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, Indiana.
Objective: For over 20 years, we have followed a cohort of patients who underwent the Mustard procedure for d-transposition of the great arteries. The current study follows the same cohort from our last study in 2007 to reassess their functional capacity and quality of life.
Participants: Of the original 45 patients, six patients have required cardiac transplant and 10 patients have died, including two of the transplanted patients. Read More
Microb Genom 2018 Nov 22. Epub 2018 Nov 22.
5Clinical Microbiology Laboratory, Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.
Much of the worldwide dissemination of antibiotic resistance has been driven by resistance gene associations with mobile genetic elements (MGEs), such as plasmids and transposons. Although increasing, our understanding of resistance spread remains relatively limited, as methods for tracking mobile resistance genes through multiple species, strains and plasmids are lacking. We have developed a bioinformatic pipeline for tracking variation within, and mobility of, specific transposable elements (TEs), such as transposons carrying antibiotic-resistance genes. Read More
Plant Cell Rep 2018 Nov 21. Epub 2018 Nov 21.
Plant Genome Engineering Research Unit, Division of Applied Genetics, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, 1-2 Owashi, Tsukuba, Ibaraki, 305-8634, Japan.
Key Message: A successful example of transposon deletion via CRISPR/Cas9-mediated genome editing suggests a novel alternative approach to plant breeding. Transposition of transposable elements (TEs) can affect adjacent genes, leading to changes in genetic traits. Expression levels and patterns, splicing and epigenetic status, and function of genes located in, or near, the inserted/excised locus can be affected. Read More
Ann Plast Surg 2019 Jan;82(1S Suppl 1):S13-S17
From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China.
Background: In this study, we present the long-term functional and aesthetic outcomes in patients with complicated asymmetric radial polydactyly treated with this surgical technique involving the transposition of a duplicated thumb.
Methods: We evaluated 6 thumbs in 6 patients who underwent radial polydactyly reconstruction using the transposition of duplicated thumb procedure between 2001 and 2017. The procedure was used when one of the thumbs was not obviously dominant over the other, with one having a better proximal portion and the other having a better distal portion. Read More
J Ind Microbiol Biotechnol 2018 Nov 20. Epub 2018 Nov 20.
Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa, 252-0373, Japan.
A 6625-base pair transposon, Tn4556, was initially isolated from a Streptomyces strain and a sequence analysis was performed; however, its annotation data remain incomplete. At least three positions were identified as frameshift and base-exchange errors by resequencing. The revised sequence revealed that Tn4556 contains four open reading frames that encode transposase, methyltransferase, isoprenyl diphosphate transferase, and resolvase, respectively. Read More