11,056 results match your criteria Transplants Renal


Liver Transplant in Acute Liver Failure - Looking Back Over 10 Years.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):322-328. Epub 2019 Oct 31.

Department of GI Surgery and Solid Organ Transplantation, Amrita Institute of Medical Sciences & Research Centre, Ponekkara, Kochi, 682041, Kerala, India.

Background: Acute liver failure (ALF) is the leading cause for emergency liver transplantation (LT) all over the world. We looked at the profile of cases who required LT for ALF from a single centre to identify the possible predictors of poor outcomes.

Methodology: During the 10-year period starting from 2007, 320 cases of ALF were treated at our institution, of which 70 (median age 24 years, Male:Female 1:2) underwent LT. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335718PMC
October 2019

Impact of Warm Ischemia Time on Outcomes for Kidneys Donated After Cardiac Death Post-KAS.

Clin Transplant 2020 Jul 12:e14040. Epub 2020 Jul 12.

New York- Presbyterian Hospital, New York, NY.

Prolonged warm(WIT) and cold(CIT) ischemia times are often important considerations in the discard of DCD kidneys, but their impact on post-transplant outcomes in the post-KAS era is unclear. We examined the association of ischemia time on delayed graft function(DGF) and death-censored graft failure for DCD kidneys. The 2018 SRTR SAF was utilized to identify post-KAS DCD kidney transplants occurring from 2015-2018. Read More

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http://dx.doi.org/10.1111/ctr.14040DOI Listing

Tissue-resident Mucosal-associated invariant T (MAIT) cells in the human kidney represent a functionally distinct subset.

Eur J Immunol 2020 Jul 11. Epub 2020 Jul 11.

Amsterdam UMC, University of Amsterdam, Division of Internal Medicine, Department of Nephrology, Renal Transplant Unit, Amsterdam Infection & Immunity Institute (AI&II), Meibergdreef 9, Amsterdam, The Netherlands.

Mucosal-associated invariant T (MAIT) cells are innate-like T-cells that recognize bacterial riboflavin metabolites. They are present in human blood but are abundant at barrier sites including the liver, lungs, and kidneys, where they possess a CD69 /CD103 tissue-resident phenotype. In renal tissue, MAIT cells likely defend against the ascending uropathogens responsible for urinary tract infections (UTIs), which are common, especially among renal transplant recipients (RTRs). Read More

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http://dx.doi.org/10.1002/eji.202048644DOI Listing

Robotic Surgery for the Reconstruction of Transplant Ureteral Strictures.

Urology 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, The University of California, San Diego, San Diego, CA.

Objective: To demonstrate the feasibility and success of a robotic approach to reconstruction of ureterovesical anastomotic strictures in kidney transplants.

Materials And Methods: Between November 2017 and December 2019, a total of 5 patients with transplant ureteral stricture were identified and treated with robot assisted laparoscopic repair. All patients were confirmed to have ureteral stricture with a pre-operative antegrade nephrostogram through their nephrostomy tube and cystogram. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.041DOI Listing

A Pediatric Case of Sirolimus-Associated Pneumonitis After Kidney Transplantation.

J Pediatr Pharmacol Ther 2020 ;25(5):459-464

Sirolimus is an immunosuppressive medication often used in solid organ transplantation. It has been associated with severe side effects, including pulmonary toxicity. In adult patients, a single center study found that 14% of those treated with sirolimus developed pulmonary pneumonitis; however, the incidence in the pediatric population is not known. Read More

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http://dx.doi.org/10.5863/1551-6776-25.5.459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337132PMC
January 2020

Therapeutic Drug Monitoring of Inhaled Tobramycin in a Post-Hematopoietic Cell Transplant Patient With Bronchiolitis Obliterans and End-Stage Renal Disease.

J Pediatr Pharmacol Ther 2020 ;25(5):451-454

There are no widely accepted dose alterations for inhaled tobramycin in the setting of renal dysfunction, and serum concentrations are not typically monitored. Herein we describe a case report of a 16-year-old female with a history of 2 hematopoietic cell transplants and a kidney transplant who received inhaled tobramycin for chronic management. The patient developed chronic kidney disease, and tobramycin concentrations were monitored. Read More

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http://dx.doi.org/10.5863/1551-6776-25.5.451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337126PMC
January 2020

Impact of Pancreas Transplantation on the Patient Survival-An Analysis of the Japanese Pancreas Transplants Registry.

J Clin Med 2020 Jul 6;9(7). Epub 2020 Jul 6.

The Japan Pancreas Transplant Registry, Japan Society for Pancreas & Islet Transplantation, Osaka 565-0871, Japan.

Background: The impact of pancreas transplantation, including kidney transplantation on patients' life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation.

Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Read More

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http://dx.doi.org/10.3390/jcm9072134DOI Listing

Obesity in Living-Donor Kidney Transplant: What Risks for the Donor and the Recipient?

Exp Clin Transplant 2020 Jul 6. Epub 2020 Jul 6.

From the Nephrology and Kidney Transplantation Unit, University Hospital Mohammed VI, and the Laboratory of Epidemiology, Clinical Research and Public Health, Medical School, University Mohammed First, Oujda, Morocco.

For a kidney transplant candidate, a living-donor kidney transplant is the best option: it offers the longest survival to the recipient. Currently, more than 27000 living-donor kidney transplants are done each year in the world. More than 25% of all living kidney donors are now considered obese at the time of donation compared with fewer than 8% in the 1970s, and the proportion of obese recipients is doubling every 15 years as a result of the global epidemic of obesity. Read More

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http://dx.doi.org/10.6002/ect.2020.0074DOI Listing

Living Donor Kidney Transplantation Improves Graft and Recipient Survival in Patients with Multiple Kidney Transplants.

J Clin Med 2020 Jul 5;9(7). Epub 2020 Jul 5.

Regional Nephrology and Transplant Unit, Belfast City Hospital, 51 Lisburn Road, Belfast BT9 7AB, UK.

Background: Failed kidney transplant recipients benefit from a new graft as the general incident dialysis population, although additional challenges in the management of these patients are often limiting the long-term outcomes. Previously failed grafts, a long history of comorbidities, side effects of long-term immunosuppression and previous surgical interventions are common characteristics in the repeated kidney transplantation population, leading to significant complex immunological and technical aspects and often compromising the short- and long-term results. Although recipients' factors are acknowledged to represent one of the main determinants for graft and patient survival, there is increasing interest in expanding the donor's pool safely, particularly for high-risk candidates. Read More

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http://dx.doi.org/10.3390/jcm9072118DOI Listing

Cytomegalovirus Infection in Postrenal Transplant Recipients: 18 Years' Experience From a Tertiary Referral Center.

Transplant Proc 2020 Jul 2. Epub 2020 Jul 2.

Department of Urology, Andrology, and Transplant Surgery, Fortis Hospital, Mohali, India.

Background: Cytomegalovirus (CMV) reactivation or infection is one of the most important infectious complications in transplant recipient leading to significant morbidity and mortality. Its early detection and prompt treatment is imperative to improve transplant outcome. The present study estimated the frequency of CMV in renal transplant recipients (RTR). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.162DOI Listing

Outcomes of liver-kidney transplantation in patients with primary hyperoxaluria: an analysis of the scientific registry of transplant recipients database.

BMC Gastroenterol 2020 Jul 3;20(1):208. Epub 2020 Jul 3.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.

Background: Primary hyperoxaluria (PH) is an inherited disease lacking of hepatic oxalic acid metabolic enzymes which could lead to irreverisible renal damage. Currently, liver-kidney transplantation is a curative but highly invasive therapy used to treat patients with PH. However, limited studies have focused on combined liver-kidney transplantation (CLKT) and sequential liver and kidney transplantation (SLKT) in patients with PH. Read More

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http://dx.doi.org/10.1186/s12876-020-01349-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333252PMC

Kidney transplantation from small pediatric donors may be feasible to those who developed chronic refractory dialysis hypotension: a single-center experience.

Ann Transl Med 2020 Jun;8(11):683

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: Chronic refractory dialysis hypotension (CRDH) is a serious issue in dialysis patients waiting for transplants. It leads to fatal clinical outcomes and disqualification from kidney transplantation. Kidney transplantation from pediatric donor to adult patient with lower blood pressure (BP) may be an option. Read More

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http://dx.doi.org/10.21037/atm-20-304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327316PMC

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore.

Transplant Direct 2020 Jun 8;6(6):e554. Epub 2020 May 8.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Read More

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http://dx.doi.org/10.1097/TXD.0000000000001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363PMC

The impact of switching to mTOR inhibitor-based immunosuppression on long-term non-melanoma skin cancer incidence and renal function in kidney and liver transplant recipients.

Ren Fail 2020 Nov;42(1):607-612

Department of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Solid organ transplantation is associated with increased risk of non-melanoma skin cancer. Studies with short follow up times have suggested a reduced occurrence of these cancers in recipients treated with mammalian target of rapamycin inhibitors as maintenance immunosuppression. We aimed to describe the occurrence of skin cancers in renal and liver transplant recipients switched from calcineurin inhibitor to sirolimus-based regimes. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1785499DOI Listing
November 2020

The Importance of Kidney Medullary Tissue for the Accurate Diagnosis of BK Virus Allograft Nephropathy.

Clin J Am Soc Nephrol 2020 Jul;15(7):1015-1023

Department of Renal Medicine, Westmead Hospital, Sydney, New South Wales, Australia.

Background And Objectives: The published tissue adequacy requirement of kidney medulla for BK virus allograft nephropathy diagnosis lacks systematic verification and competes against potential increased procedural risks from deeper sampling.

Design, Setting, Participants, & Measurements: We evaluated whether the presence of kidney medulla improved the diagnostic rate of BK nephropathy in 2244 consecutive biopsy samples from 856 kidney transplants with detailed histologic and virologic results.

Results: Medulla was present in 821 samples (37%) and correlated with maximal core length (=0. Read More

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http://dx.doi.org/10.2215/CJN.13611119DOI Listing

Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation.

J Clin Invest 2020 Jun 29. Epub 2020 Jun 29.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Although the immune response within draining lymph nodes (DLNs) has been studied for decades, how their stromal compartment contributes to this process remains to be fully explored. Here, we show that donor mast cells were prominent activators of collagen I deposition by fibroblastic reticular cells (FRCs) in DLNs shortly following transplantation. Serial analysis of the DLN indicated that the LN stroma did not return to its baseline microarchitecture following organ rejection and that the DLN contained significant fibrosis following repetitive organ transplants. Read More

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http://dx.doi.org/10.1172/JCI136618DOI Listing

Patient and center characteristics associated with kidney transplant outcomes: a binational registry analysis.

Transpl Int 2020 Jun 26. Epub 2020 Jun 26.

Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.

This registry-based study evaluated the contribution of center characteristics to kidney transplant outcomes in adult first kidney transplant recipients in Australia and New Zealand between 2004 and 2014. Primary outcomes were mortality and graft failure Secondary outcomes were transplant complications. Overall, 6970 transplants from 17 centers were included. Read More

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http://dx.doi.org/10.1111/tri.13681DOI Listing

ABO-Incompatible Kidney Transplantation After Bone Marrow Transplantation: A Case Report.

Transplant Proc 2020 Jun 22. Epub 2020 Jun 22.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Many studies have been made on ABO-compatible kidney transplants following hematopoietic stem cell transplantation. However, there have been few reports on ABO-incompatible kidney transplantation following hematopoietic stem cell transplantation (HSCT). We report on the case of a successful ABO-incompatible kidney transplantation with high titers after bone marrow transplantation experienced no infectious episodes. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.173DOI Listing

Perioperative Outcomes of Laparoscopic Radical Nephrectomy for Renal Mass in Patients on Dialysis or With Renal Transplant in Place Compared to Normal Controls.

J Laparoendosc Adv Surg Tech A 2020 Jun 23. Epub 2020 Jun 23.

Department of Urology, Mayo Clinic, Jacksonville, Florida, USA.

The risk of renal cell carcinoma (RCC) development in the native kidney of patients on dialysis or with a renal transplant is increased compared to the general population. This study examines perioperative outcomes of laparoscopic radical nephrectomy (LN) in dialysis patients or renal transplant patients compared to normal controls. Four hundred twelve consecutive LN were evaluated (July 2007 to October 2018). Read More

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http://dx.doi.org/10.1089/lap.2020.0383DOI Listing

Immunosuppression in Donation after Circulatory Determination of Death Liver Transplantation: Can Induction Modify Graft Survival?

Liver Transpl 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States.

Background: Recipients of donation after circulatory determination of death (DCDD) liver transplants historically have an increased risk of graft failure. Antibody induction (AI) with anti-thymocyte globulin (ATG) or anti-IL2 receptor (anti-IL-2R) immunotherapy may decrease the incidence of graft failure by mitigating ischemia reperfusion injury.

Methods: A retrospective review of the UNOS database for liver transplants between 2002 and 2015 was conducted to determine whether ATG or anti-IL-2R AI was associated with graft survival in DCDD. Read More

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http://dx.doi.org/10.1002/lt.25762DOI Listing

The suppressive effect on CD4 T-cell alloresponse against endothelial HLA-DR via PD-L1 induced by anti-A/B ligation.

Clin Exp Immunol 2020 Jun 23. Epub 2020 Jun 23.

Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.

While donor specific human leukocyte antigen (HLA) antibodies are a frequent cause for chronic antibody-mediated rejection in organ transplantation, this is not the case for antibodies targeting blood group antigens, as ABO-incompatible (ABO-I) organ transplantation has been associated with a favorable graft outcome. Here, we explored the role of CD4 T-cell-mediated alloresponses against endothelial HLA-DR in the presence of anti-HLA-class I or anti-A/B antibodies. CD4 T-cells, notably CD45RA-memory CD4 T-cells, undergo extensive proliferation in response to endothelial HLA-DR. Read More

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http://dx.doi.org/10.1111/cei.13482DOI Listing

Analysis of Organ Utilization From Deceased Organ Donation in India.

Transplant Proc 2020 Jun 20. Epub 2020 Jun 20.

Department of Renal Transplant Surgery, Nehru Building, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Objectives: This report presents an audit of utilization of various organs from deceased donors in different states of India over a 3-year period METHODS: Data released by the various regions on their official website was analyzed from 2015 to 2017.Regions with less than 25 donations per year were excluded while calculating utilization rates.

Results: Total organ donation in India had increased from 570 to 843 donations from 2015 to 2017 (47. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.134DOI Listing

Recipient and allograft survival following donation after circulatory death versus donation after brain death for renal transplantation: A systematic review and meta-analysis.

Transplant Rev (Orlando) 2020 Jun 13:100563. Epub 2020 Jun 13.

Department of Vascular Access and Renal Transplantation, Queen Elizabeth University Hospitals Birmingham NHS Foundation Trust, B15 2TH, UK.

Background-objectives: Current evidence based on retrospective and prospective studies demonstrates that donation after circulatory death (DCD) grafts are more susceptible to delayed graft function (DGF) than donation after brain death (DBD) grafts. The short- and long-term survival outcomes of the two cohorts are unclear. Therefore, we performed a systematic review and meta-analysis to estimate the patient and allograft survival outcomes for DCD and DBD in renal transplant surgery. Read More

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http://dx.doi.org/10.1016/j.trre.2020.100563DOI Listing

Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study.

Int J Mol Sci 2020 Jun 19;21(12). Epub 2020 Jun 19.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine modulates lipogenesis-related transcriptional factor SREBP-1/2 in proximal tubular cells by inhibiting the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway in vitro. However, the mechanisms by which nifedipine (NF) modulates lipotoxicity in vivo are unclear. Read More

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http://dx.doi.org/10.3390/ijms21124359DOI Listing

Protocolized Exercise Improves Frailty Parameters and Lower Extremity Impairment: A Promising Prehabilitation Strategy for Kidney Transplant Candidates.

Clin Transplant 2020 Jun 23:e14017. Epub 2020 Jun 23.

William J von Liebig Center for Transplantation and Clinical Regeneration, USA.

Background: Frailty and decreased functional status are risk factors for adverse kidney transplant (KT) outcomes. Our objective was to examine the efficacy of an exercise intervention on frailty and decreased functional status in a cohort of patients with advanced chronic kidney disease (CKD).

Methods: We conducted a prospective study involving 21 adults with ≥ stage 4 CKD who were 1) frail or pre-frail by Fried phenotype and/or 2) had lower extremity impairment [Short Physical Performance Battery score ≤ 10]. Read More

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http://dx.doi.org/10.1111/ctr.14017DOI Listing

Financial Impact of Delayed Graft Function in Kidney Transplantation.

Clin Transplant 2020 Jun 23:e14022. Epub 2020 Jun 23.

Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA.

Increased utilization of suboptimal organs in response to organ shortage has resulted in increased incidence of delayed graft function (DGF) after transplantation. Although presumed increased costs associated with DGF is a deterrent to the utilization of these organs, the financial burden of DGF has not been established. We used the Premier Healthcare Database to conduct a retrospective analysis of healthcare resource utilization and costs in kidney transplant patients (n=12,097) between 1/1/2014-12/31/2018. Read More

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http://dx.doi.org/10.1111/ctr.14022DOI Listing

Strict selection criteria in uncontrolled donation after circulatory death provides excellent long-term kidney graft survival.

Clin Transplant 2020 Jun 23:e14010. Epub 2020 Jun 23.

Transplant Coordination Unit & Service of Intensive Care, University Hospital Marqués de Valdecilla-IDIVAL. Santander, Spain.

Background: We aimed to report our experience in uncontrolled donation after circulatory death (uDCD) kidney transplantation applying a strict donor selection and preservation criteria.

Methods: All kidney recipients who received a graft from a local uDCD. As controls we included all renal transplants from local standard criteria brain death donors (DBD). Read More

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http://dx.doi.org/10.1111/ctr.14010DOI Listing

Robot-assisted Synchronous Bilateral Nephrectomy for Autosomal Dominant Polycystic Kidney Disease: a Stepwise Description of Technique.

Urology 2020 Jun 17. Epub 2020 Jun 17.

Department of Urology, University of Rochester Medical Center (URMC), Rochester, New York, U.S.

Objective: To describe our technique of robot-assisted synchronous bilateral nephrectomy (RASBN) for autosomal dominant polycystic kidney disease (ADPKD).

Methods: Given prior abdominal surgery/transplant in most patients, we prefer an open cut-down access to place a 12mm port 10cm infra-umbilically. Four (8mm) robotic ports are then placed under vision in a fan distribution along the umbilical level. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.069DOI Listing

Guy Alexandre - An appreciation of his innovative contributions to organ transplantation.

Authors:
David K C Cooper

Transpl Immunol 2020 Aug 15;61:101309. Epub 2020 Jun 15.

Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Guy Alexandre made major contributions to organ transplantation that, in my opinion, have not been sufficiently recognized by the transplant community. To make his contributions better known, I present a brief summary of the innovations for which he was largely responsible. As a research fellow at the Peter Bent Brigham Hospital in Boston in 1962-3, under subsequent Nobelist Joseph Murray, he contributed to the establishment of pharmacologic immunosuppressive therapy (initiated by Roy Calne) in patients undergoing renal allotransplantation. Read More

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http://dx.doi.org/10.1016/j.trim.2020.101309DOI Listing

Influence of CYP3A5 Genetic Polymorphism on Long-Term Renal Function in Chinese Kidney Transplant Recipients Using Limited Sampling Strategy and Abbreviated Area Under the Curve for Tacrolimus Monitoring.

Prog Transplant 2020 Jun 17:1526924820933823. Epub 2020 Jun 17.

Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands.

Introduction: Although the association between CYP3A5 gene polymorphism and tacrolimus dosing requirements was well established, the impact on how CYP3A5 genotype affects the acute rejection and long-term renal function in patients who received kidney transplants and were treated with tacrolimus remained controversial.

Design: Sixty-seven Chinese patients with kidney transplants receiving de novo tacrolimus-based immunosuppressive therapy with known CYP3A5 genotype were divided into 2 groups. Those with at least 1 CYP3A5*1 allele were CYP3A5 expressers while homozygotes for the mutant allele CYP3A5*3 were nonexpressers. Read More

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http://dx.doi.org/10.1177/1526924820933823DOI Listing

Expanded criteria donors in deceased donor kidney transplantation - An Asian perspective.

Indian J Urol 2020 Apr-Jun;36(2):89-94. Epub 2020 Apr 7.

Department of Urology, National University Hospital, Singapore.

There is an increasing gulf between demand and supply for kidneys in end-stage renal failure patients worldwide, especially Asia. Renal transplantation is often the treatment of choice for long-suffering patients who have to undergo dialysis on a regular basis. The utilization of expanded criteria donors (ECDs) to address the donor pool shortage has been proven to be a legitimate solution. Read More

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http://dx.doi.org/10.4103/iju.IJU_269_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279103PMC

Enteric Conversion of Bladder-drained Pancreas as a Predictor of Outcomes in Almost 600 Recipients at a Single Center.

Transplant Direct 2020 May 22;6(5):e550. Epub 2020 Apr 22.

Division of Transplant Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN.

Complications associated with bladder-drained pancreata necessitating enteric conversion are common. Data on the outcomes after enteric conversion are conflicting. We studied the association between enteric conversion and the pancreas graft rejection, loss, and mortality. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213611PMC

Deceased donation and organ transplantation in Mexico. Analysis of 12 years and seven strategic proposals.

Cir Cir 2020 ;88(3):254-262

Servicio Hospitalario de la Donación, Unidades Médicas de Alta Especialidad, Hospital de Especialidades N.º 1, Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, León, Guanajuato. México.

Background: The evolution of the activity of deceased organ donation and solid organ transplantation in Mexico was analyzed for the period of 2004-2018.

Method: The information of deceased donation and organ transplantation in Mexico was collected and ordered for said period. When there was no complete information for 2018, the data for 2017 were used instead. Read More

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http://dx.doi.org/10.24875/CIRU.19001379DOI Listing
January 2020

[Renal transplantation during COVID-19 period in Spain.]

Arch Esp Urol 2020 Jun;73(5):447-454

Hospital Reina Sofía. Córdoba. España.

Introduction: The COVID-19 pandemic poses significant challenges in the area of kidney donation and transplantation. The objective of this article is to establish general recommendations for surgical teams to manage the kidney transplant program duringthe COVID-19 era. MATERIAL AND METHODS: This document is based on the scientific evidence available on the infection caused by SARS-CoV-2 and the experience of authors during the COVID-19 pandemic. Read More

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Renal transplantation using vascular conduit reconstruction in deceased kidneys with multiple renal arteries and short renal veins.

Actas Urol Esp 2020 Jun 11. Epub 2020 Jun 11.

Department of Surgery, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, Estados Unidos; Urology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, Estados Unidos; Miami Transplant Institute, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, Estados Unidos. Electronic address:

Background: Transplantation of kidneys with vascular anatomical variants remains a challenge. Due to its varying success in regard to graft function after transplantation, these organs have been frequently discarded assuming in advance an unaffordable rate of vascular complications.

Patients And Methods: We performed three kidney transplants using organs from deceased donors harboring vascular variants (multiple arteries and short veins), including an unsplittable horseshoe kidney. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.01.013DOI Listing

Implications of perioperative allogeneic red blood cell transfusion on the immune-inflammatory response.

Hematol Transfus Cell Ther 2020 May 17. Epub 2020 May 17.

Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital Alemão Oswaldo Cruz, São Paulo, SP, Brazil.

Background: The allogeneic transfusion-related immunomodulation (TRIM) may be responsible for an increase in survival of renal transplants but in contrast it could increase the rate of bacterial infections or the recurrence rate of tumors post-operatively.

Objective: This review focuses in the implications of perioperative allogeneic transfusions on the immune-inflammatory response of surgical transfused patients.

Results: ABTs modify immune functions in recipients including decrease of the number of lymphocytes; decrease the CD4 cells; decrease the CD4/CD8 T-cell ratio; decrease NK cells; and decrease the lymphocyte response to mitogens. Read More

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http://dx.doi.org/10.1016/j.htct.2020.03.003DOI Listing

N-glycosylated IgG in patients with kidney transplants increases calcium/calmodulin kinase IV in podocytes and causes injury.

Am J Transplant 2020 Jun 12. Epub 2020 Jun 12.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Transplant glomerulopathy (TG) is a major cause of late allograft loss. Increased urine podocin/creatinine ratio in TG signifies accelerated podocyte loss. The mechanisms that lead to podocyte injury in TG remain unclear. Read More

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http://dx.doi.org/10.1111/ajt.16140DOI Listing

Does whole body vibration training improve heart rate variability in kidney transplants patients? A randomized clinical trial.

J Bodyw Mov Ther 2020 Apr 1;24(2):50-56. Epub 2019 Jun 1.

Post-Graduation Program Health Sciences, Universidade Federal de Pernambuco, Recife, PE, Brazil; Post-Graduation Program in Physical Therapy, Universidade Federal de Pernambuco, Recife, Brazil. Electronic address:

Background: Whole-body vibration (WBV) is an exercise modality that can promote improvements in heart rate variability (HRV) with lower patient overload, and consequently reduce cardiovascular risk in renal transplant patients. The aim of this study was to evaluate the effects of a 12-week WBV training program of two weekly sessions on HRV.

Methods: A double-blind, randomized controlled clinical trial with 12 kidney transplant recipients of both genders who underwent WBV training (35 Hz) twice a week for 12 weeks on alternate days (WBV Group) and training with sub-therapeutic WBV (8 Hz) (Sham Group). Read More

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http://dx.doi.org/10.1016/j.jbmt.2019.05.031DOI Listing

Double Single-Side Kidney Transplants With Bench Vascular Reconstruction: A Further Challenge Beyond the Marginality Without Future Preclusions.

Transplant Proc 2020 Jun 3;52(5):1544-1546. Epub 2020 Jun 3.

Department of Organ Insufficiencies and Transplantation, General Surgery and Transplantation, University Hospital of Bologna, Bologna, Italy.

Background: Double kidney transplantation allows the use of marginal kidneys with a significant improvement in the recovery of renal function expected after transplantation, although with a greater anesthesiologic and surgical risk. One-sided positioning, more cautious in the event of functional exhaustion, can be complex due to vascular anomalies.

Materials And Methods: We report the case of 2 double unilateral kidney transplants with vascular reconstructions. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.184DOI Listing

MiRNAs as potential biomarker of kidney diseases: A review.

Cell Biochem Funct 2020 Jun 4. Epub 2020 Jun 4.

Department of Nephrology, Kidney Care, Tiruchirappalli, India.

MicroRNAs (miRNAs) are 22 nucleotides short, non-coding and tissue-specific single-stranded RNA which modulates target gene expression. Presently, shreds of evidence confirmed that miRNAs play a key role in kidney pathophysiology. The objectives of the present review are to summarize new research data towards the latest developments in the potential use of miRNAs as a diagnostic biomarker for kidney diseases. Read More

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http://dx.doi.org/10.1002/cbf.3555DOI Listing

COVID-19 and kidney transplantation: an Italian Survey and Consensus.

J Nephrol 2020 Jun 3. Epub 2020 Jun 3.

Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

Italy was the first Western country to face the COVID-19 pandemic. Here we report the results of a national survey on kidney transplantation activity in February and March 2020, and the results of a three-round Delphi consensus promoted by four scientific societies: the Italian Society of Organ Transplantation, the Italian Society of Nephrology, the Italian Society of Anesthesia and Intensive Care, and the Italian Group on Antimicrobial Stewardship. All 41 Italian transplant centers were invited to express their opinion in the Delphi rounds along with a group of seven experts. Read More

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http://dx.doi.org/10.1007/s40620-020-00755-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268183PMC

Gut Microbial Metabolites Induce Donor-Specific Tolerance of Kidney Allografts through Induction of T Regulatory Cells by Short-Chain Fatty Acids.

J Am Soc Nephrol 2020 Jul 1;31(7):1445-1461. Epub 2020 Jun 1.

Kidney Node Laboratory, The Charles Perkins Centre, Camperdown, New South Wales, Australia.

Background: Short-chain fatty acids derived from gut microbial fermentation of dietary fiber have been shown to suppress autoimmunity through mechanisms that include enhanced regulation by T regulatory cells (Tregs).

Methods: Using a murine kidney transplantation model, we examined the effects on alloimmunity of a high-fiber diet or supplementation with the short-chain fatty acid acetate. Kidney transplants were performed from BALB/c(H2) to B6(H2) mice as allografts in wild-type and recipient mice lacking the G protein-coupled receptor GPR43 (the metabolite-sensing receptor of acetate). Read More

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http://dx.doi.org/10.1681/ASN.2019080852DOI Listing

Contrast Administration to the Deceased Kidney Donor Has No Impact on Post-Transplant Outcomes.

J Surg Res 2020 May 29;254:261-267. Epub 2020 May 29.

Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Contrast-induced acute kidney injury may occur in patients undergoing imaging studies. This study reviews all deceased kidney donors at a single center during a 15-y period to determine if donor contrast exposure results in contrast-induced acute kidney injury in the donor or is associated with worse outcomes in the transplant recipient.

Methods: Donor and recipient renal functions were recorded, including donor serum creatinine and recipient delayed graft function, creatinine clearance at 1 y, and early and late graft survival. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.061DOI Listing

Kidney transplantation and other methods of renal replacement therapy in children: 30 years of observations in one center.

Adv Clin Exp Med 2020 May;29(5):611-613

Department of Pediatric Nephrology, Wroclaw Medical University, Poland.

Background: Kidney transplantation (Tx) is regarded as the optimal treatment method for renal replacement therapy (RRT) for end-stage renal disease (ESRD) patients. Children qualified for Tx should receive the organ as soon as possible in order to improve their chances for healthy development. In our center, RRT for children with ESRD has been conducted for 36 years: hemodialysis (HD) since 1982, peritoneal dialysis (PD) since 1992 and the first transplant in 1987. Read More

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http://dx.doi.org/10.17219/acem/121928DOI Listing

The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.

Transplantation 2020 May 25. Epub 2020 May 25.

Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States, 94143.

Background: Acute kidney injury (AKI) after liver transplantation is associated with increased morbidity and mortality. It remains controversial whether the choice of vena cava reconstruction technique impacts AKI.

Methods: This is a single-center retrospective cohort of 897 liver transplants performed between June 2009 and September 2018 using either the vena-cava preserving piggyback technique or caval replacement technique without veno-venous bypass or shunts. Read More

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http://dx.doi.org/10.1097/TP.0000000000003331DOI Listing

Effect of kidney transplantation on right ventricular function, assessment by 2- dimensional speckle tracking echocardiography.

Cardiovasc Ultrasound 2020 May 26;18(1):16. Epub 2020 May 26.

Cardiovascular Research Center Shahid Beheshti University of Medical Sciences, Po.Box: 1998734383, Tehran, Iran.

Background: Advanced chronic kidney disease often results in adverse cardiovascular outcomes and is the leading cause of mortality in patients with end stage renal diseases (ESRD). There is much information about the effect of chronic kidney diseases (CKD) on the left ventricle (LV) chamber, but the right ventricle (RV) as a neglected chamber had not been evaluated precisely, in spite of its importance.

Objectives: The aim of this study was to evaluate the impact of successful kidney transplants on the RV systolic and diastolic function using the advanced method of 2D speckle tracking echocardiography and comparison with the conventional methods. Read More

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http://dx.doi.org/10.1186/s12947-020-00200-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251705PMC

Multiparametric Assessment of Changes in Renal Tissue after Kidney Transplantation with Quantitative MR Relaxometry and Diffusion-Tensor Imaging at 3 T.

J Clin Med 2020 May 21;9(5). Epub 2020 May 21.

Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany.

Background: Magnetic resonance relaxometry (MRR) offers highly reproducible pixel-wise parametric maps of T1 and T2 relaxation times, reflecting specific tissue properties, while diffusion-tensor imaging (DTI) is a promising technique for the characterization of microstructural changes, depending on the directionality of molecular motion. Both MMR and DTI may be used for non-invasive assessment of parenchymal changes caused by kidney injury or graft dysfunction.

Methods: We examined 46 patients with kidney transplantation and 16 healthy controls, using T1/T2 relaxometry and DTI at 3 T. Read More

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http://dx.doi.org/10.3390/jcm9051551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290480PMC

Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation.

Case Rep Transplant 2020 11;2020:6152035. Epub 2020 May 11.

Department of Clinical and Experimental Medicine, Division of Metabolism and Cell Transplantation, University of Pisa, Pisa, Italy.

Subcapsular renal hematoma (SRH) is a challenging condition, which may jeopardize kidney function or constitute a life-threatening event. This is particularly true in single-kidney patients, such as kidney-transplant recipients. SRH may exert an excessive pressure on the surrounding parenchyma, thus resulting in hypoperfusion and ischemia, with high risk of acute kidney failure and graft loss. Read More

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http://dx.doi.org/10.1155/2020/6152035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238346PMC

Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis.

Kidney Int 2020 May 23. Epub 2020 May 23.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

Donor-recipient (D-R) differences at human leukocyte antigen (HLA) loci are currently incorporated into organ sharing, allocation and immunosuppression decisions. However, while acute rejection episodes have substantially diminished, progressive histologic damage occurs in allografts and improved long-term survival remains an unrealized goal among kidney recipients. Here we tested the hypothesis that non-HLA dependent, genome-wide D-R genetic differences. Read More

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http://dx.doi.org/10.1016/j.kint.2020.04.039DOI Listing

Donor insulin use predicts beta-cell function after islet transplantation.

Diabetes Obes Metab 2020 May 25. Epub 2020 May 25.

Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.

Insulin is routinely used to manage hyperglycaemia in organ donors and during the peri-transplant period in islet transplant recipients. However, it is unknown whether donor insulin use (DIU) predicts beta-cell dysfunction after islet transplantation. We reviewed data from the UK Transplant Registry and the UK Islet Transplant Consortium; all first-time transplants during 2008-2016 were included. Read More

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http://dx.doi.org/10.1111/dom.14088DOI Listing