10,377 results match your criteria Transplants Renal


NAV-KIDS trial: protocol for a multi-centre, staggered randomised controlled trial of a patient navigator intervention in children with chronic kidney disease.

BMC Nephrol 2019 Apr 18;20(1):134. Epub 2019 Apr 18.

Centre for Kidney Research at The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Background: Chronic kidney disease (CKD) is a devastating illness associated with increased mortality, reduced quality of life, impaired growth, neurocognitive impairment and psychosocial maladjustment in children. There is growing evidence of socioeconomic disparities in health outcomes among children with CKD. Patient navigators are trained non-medical personnel who assist patients with chronic conditions journey through the continuum of care and transit across different care settings. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1325-yDOI Listing
April 2019
2 Reads

Kidney transplant from uncontrolled donation after circulatory death: contribution of normothermic regional perfusion.

Transplantation 2019 Apr 8. Epub 2019 Apr 8.

Hôpital de la Pitié Salpêtrière, Paris, France.

Background: The French uncontrolled DCD protocol restricts donor age to <55years, No-Flow time to <30min and functional warm ischemia time to <150min. In situ kidney perfusion can be performed at either 4°C (in situ cooling, ISC) or 33-36°C (normothermic regional perfusion, NRP). Hypothermic machine perfusion is systematically used. Read More

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http://dx.doi.org/10.1097/TP.0000000000002753DOI Listing
April 2019
1 Read

Very Early Cytomegalovirus Infection After Renal Transplantation: A Single-Center 20-Year Perspective.

Virology (Auckl) 2019 2;10:1178122X19840371. Epub 2019 Apr 2.

Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.

Background: Cytomegalovirus (CMV) infection risk in the first month after transplantation is felt to be minimal; however, the epidemiology has not been specifically investigated, particularly in the modern era of potent immunosuppressive regimens and universal CMV prophylaxis.

Objective: The aim of this study was to describe the incidence of and risk factors associated with CMV occurring less than 30 days after transplant and evaluate the effect of very early CMV on outcomes.

Methods: Retrospective, single-center study of adult renal transplant (RTX) recipients between January 1, 1994 and December 31, 2014. Read More

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http://dx.doi.org/10.1177/1178122X19840371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448111PMC

Recurrent Aphthous Stomatitis Caused by Cytomegalovirus, Herpes Simplex Virus, and Candida Species in a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2019 Apr 26;51(3):993-997. Epub 2019 Jan 26.

Department of Urology, Kyoto University Hospital, Kyoto, Japan.

Recipients of organ transplants are immunosuppressed and at high risk of oral infection. Oral diseases are often neglected compared with infections of other organs that typically confer higher morbidity. However, severe local symptoms hinder oral intake, decrease quality of life, and are sometimes lethal. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.058DOI Listing
April 2019
1 Read

Pretransplant Single Antigen Bead-Detected HLA Antibodies in Kidney Transplant Long-term Outcome: A Single-Center Cohort Experience.

Transplant Proc 2019 Apr 26;51(3):707-714. Epub 2019 Jan 26.

North Italy Transplant program (NITp), UOC Coordinamento Trapianti, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.

Single-antigen bead (SAB) platform permits the identification of antibodies not detectable by complement-dependent lymphocytotoxicity test, but their clinical significance is not completely understood. The aim of this study was to evaluate whether the presence of pretransplant SAB-detected antibodies is associated with the development of allograft failure. This is a single-center cohort study with 10-year follow-up in which 573 kidney recipients with negative pretransplant complement-dependent lymphocytotoxicity crossmatch who received transplants at the Kidney Transplant Center of Policlinico, Milan, from deceased donors between 1996 and 2005 were evaluated. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.063DOI Listing

Histopathologic Findings on Implantation Renal Allograft Biopsies Correlate With Kidney Donor Profile Index and 30-Day Serum Creatinine.

Transplant Proc 2019 Apr 10;51(3):639-646. Epub 2019 Jan 10.

Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, California, USA. Electronic address:

Background: The Kidney Donor Profile Index (KDPI) provides a numerical estimate of deceased donor kidney quality. The KDPI uses 10 donor factors but it does not consider histopathologic findings. We examined whether the KDPI and its component donor factors correlate with the degree of histopathologic changes seen in implantation renal allograft biopsies. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.027DOI Listing

A Novel CNN-Based CAD System for Early Assessment of Transplanted Kidney Dysfunction.

Sci Rep 2019 Apr 11;9(1):5948. Epub 2019 Apr 11.

Bioengineering Department, University of Louisville, Louisville, KY, USA.

This paper introduces a deep-learning based computer-aided diagnostic (CAD) system for the early detection of acute renal transplant rejection. For noninvasive detection of kidney rejection at an early stage, the proposed CAD system is based on the fusion of both imaging markers and clinical biomarkers. The former are derived from diffusion-weighted magnetic resonance imaging (DW-MRI) by estimating the apparent diffusion coefficients (ADC) representing the perfusion of the blood and the diffusion of the water inside the transplanted kidney. Read More

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http://www.nature.com/articles/s41598-019-42431-3
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http://dx.doi.org/10.1038/s41598-019-42431-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459833PMC
April 2019
2 Reads

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Acute Rejection Is a Strong Negative Predictor of Graft Survival in Living-Donor Pediatric Renal Transplant: 10-Year Follow-Up in a Single Mexican Center.

Exp Clin Transplant 2019 04;17(2):170-176

From the Research Department and the Organ Transplantation Department, UMAE Hospital Especialidades 14 "Adolfo Ruiz Cortines" IMSS, Veracruz, Mexico.

Objectives: Kidney transplant is the optimal treatment for children with end-stage renal disease. Multiple factors affect patient and graft survival. We assessed determinants of long-term patient/graft survival in our center by a retrospective review of pediatric living donor (< 18 years) kidney transplants from February 2003 to December 2016. Read More

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http://dx.doi.org/10.6002/ect.2017.0265DOI Listing
April 2019
2 Reads

Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation.

Biology (Basel) 2019 Mar 31;8(2). Epub 2019 Mar 31.

Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.

Warm anoxia-reoxygenation induces ferroptotic cell death in mouse proximal renal tubular epithelial cells (RPTECs), whereas RPTECs of the native hibernator Syrian hamster resist cell death. Clarifying how hamster cells escape ferroptosis may reveal new molecular targets for preventing or ameliorating ischemia-reperfusion-induced human diseases or expanding the survival of organ transplants. Mouse or hamster RPTECs were subjected to anoxia and subsequent reoxygenation. Read More

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http://dx.doi.org/10.3390/biology8020022DOI Listing

Transplantation of adult-size kidneys in small pediatric recipients: A single-center experience.

Pediatr Transplant 2019 Mar 27:e13401. Epub 2019 Mar 27.

Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.

RTx of adult-size kidneys presents a size mismatch in small pediatric recipients, and there are potential surgical complications. This study reveals the outcomes of intra- and extraperitoneal RTx in low-weight (less than 15 kg) pediatric recipients. We studied 51 pediatric patients weighing less than 15 kg who received a living-related donor renal transplant between 2009 and 2017. Read More

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http://dx.doi.org/10.1111/petr.13401DOI Listing
March 2019
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Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study.

Rev Bras Ter Intensiva 2019 21;31(1):86-92. Epub 2019 Mar 21.

Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.

Objective: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors.

Methods: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients were divided into two groups: group 1, patients who developed primary graft dysfunction; and group 2, patients who did not develop primary graft dysfunction. Read More

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http://dx.doi.org/10.5935/0103-507X.20190009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443307PMC

Successful transplantation of kidneys from deceased donors with terminal acute kidney injury.

Ren Fail 2019 Nov;41(1):167-174

a Department of General and Transplantation Surgery , The Medical University of Warsaw , Warsaw , Poland.

Background: There are many doubts with regards to accepting deceased kidneys with acute kidney injury (AKI) for transplantation.

Purpose: The aim of this study was to present the 5-years outcome of kidney transplantation cases where deceased donors developed AKI before organ procurement.

Methods: Two hundred twenty-six deceased renal transplants were analyzed. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1590209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442227PMC
November 2019
1 Read

Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.

J Low Genit Tract Dis 2019 Apr;23(2):87-101

Department of Obstetrics and Gynecology, University of Oklahoma Tulsa, OU-TU School of Community Medicine, Tulsa, OK.

Executive Summary: The risk of cervical cancer (CC) among women immunosuppressed for a variety of reasons is well documented in the literature. Although there is improved organ function, quality of life and life expectancy gained through use of immunosuppressant therapy, there may be increased long-term risk of cervical neoplasia and cancer and the need for more intense screening, surveillance, and management. Although guidance for CC screening among HIV-infected women (see Table 1) has been supported by evidence from retrospective and prospective studies, recommendations for CC screening among non-HIV immunosuppressed women remains limited because quality evidence is lacking. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000468DOI Listing
April 2019
2 Reads

Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa.

Clin Infect Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for and treated only in pregnant women or in an individual prior to undergoing invasive urologic procedures. Treatment was not recommended for healthy women; older women or men; or persons with diabetes, indwelling catheters, or spinal cord injury. Read More

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http://dx.doi.org/10.1093/cid/ciy1121DOI Listing
March 2019
4 Reads

Successful pregnancy in a recipient of an ABO-incompatible renal allograft.

Obstet Med 2019 Mar 7;12(1):42-44. Epub 2018 Mar 7.

Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia.

Kidney transplantation restores fertility in patients with end-stage renal disease, with many successful pregnancies after kidney transplantation being reported. , there are little data regarding pregnancy in women transplanted under modern-era desensitisation protocols that utilise rituximab, plasma exchange and intravenous immunoglobulin, including ABO-incompatible transplants. Pregnancies in ABO-incompatible recipients can pose new challenges from an immunological perspective. Read More

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http://journals.sagepub.com/doi/10.1177/1753495X17745390
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http://dx.doi.org/10.1177/1753495X17745390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416689PMC
March 2019
2 Reads

Frailty and Access to Kidney Transplantation.

Clin J Am Soc Nephrol 2019 Apr 19;14(4):576-582. Epub 2019 Mar 19.

Department of Surgery,

Background And Objectives: Frailty, a syndrome distinct from comorbidity and disability, is clinically manifested as a decreased resistance to stressors and is present in up to 35% of patient with ESKD. It is associated with falls, hospitalizations, poor cognitive function, and mortality. Also, frailty is associated with poor outcomes after kidney transplant, including delirium and mortality. Read More

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http://dx.doi.org/10.2215/CJN.12921118DOI Listing
April 2019
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Shearing-force injury of a kidney transplant graft during cesarean section: a case report and review of the literature.

BMC Nephrol 2019 Mar 18;20(1):94. Epub 2019 Mar 18.

Department of Obstetrics & Gynecology, University of California, Irvine, 333 City Blvd, West - Suite 1400, Orange, CA, 92868, USA.

Background: With an increasing number of reproductive-aged women undergoing renal transplantation coupled with improved fertility post-transplantation, more women are becoming pregnant with a kidney transplant in place. This leads to increased risk of perinatal complications such as pre-eclampsia, gestational diabetes, preterm delivery and Cesarean section. Given that kidney transplants are often placed extra-peritoneally in the iliac fossa, there is also a risk of damage to the transplanted kidney at the time of Cesarean section. Read More

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http://dx.doi.org/10.1186/s12882-019-1281-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423748PMC
March 2019
1 Read

Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2018-Islet Donations, Islet Isolations, and Islet Transplants.

Transplant Direct 2019 Feb 7;5(2):e421. Epub 2019 Jan 7.

Sydney School of Public Health, Faculty of Health and Medicine, University of Sydney, Sydney, Australia.

Background: This is an excerpt from chapter 4 of the annual registry report from the Australia and New Zealand islet and pancreas transplant registry. The full report is available at http://anziptr.org/reports/. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415971PMC
February 2019
1 Read

Control of replication of hepatitis B and C virus improves patient and graft survival in kidney transplantation.

J Hepatol 2019 May 14;70(5):831-838. Epub 2019 Mar 14.

CHRU de Lille, France, Service des maladies de l'appareil digestif, Université Lille 2 and Inserm U795, France. Electronic address:

Background & Aims: Before antiviral therapy, kidney transplant recipients infected with hepatitis B virus (HBV) or hepatitis C virus (HCV) had poor outcomes. Since the 90s, nucleos(t)ide analogues have been widely used in HBV-infected patients, while interferon-based therapy was rarely used in HCV-infected patients. The aim of this study was to assess the impact of HBV and HCV on patient and graft survival, according to viral replication status. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.12.036DOI Listing
May 2019
4 Reads

Kidney Transplantation After Hematopoietic Cell Transplantation in Plasma Cell Dyscrasias: Case Reports.

Transplant Proc 2019 Mar 28;51(2):383-385. Epub 2018 Oct 28.

Nephrology Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

The plasma cell dyscrasias (PCDs) include a number of entities such as multiple myeloma, primary amyloidosis, and monoclonal immunoglobulin deposition disease. Hematopoietic cell transplant (HCT) is the only cure for a variety of hematologic and oncologic diseases. Clinically significant renal impairment is a common feature in plasma cell myeloma, affecting 20% to 55% of patients at initial diagnosis; 2% to 3% of patients present with failure sufficiently severe to require hemodialysis. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.005DOI Listing

Influence of Pre-renal Transplant Secondary Hyperparathyroidism on Later Evolution After Transplantation.

Transplant Proc 2019 Mar 12;51(2):344-349. Epub 2018 Dec 12.

Department of Nephrology, University Hospital Reina Sofía, Córdoba, Spain.

Persistence of secondary hyperparathyroidism (SHPT) is common after renal transplantation. Good diagnosis and treatment are important to avoid complications. The objective of our work was to perform a retrospective analysis of the evolution of SHPT after renal transplantation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.012DOI Listing
March 2019
1 Read

Usefulness of Delayed Introduction of Tacrolimus in Kidney Transplants Using Type-III Donors After Circulatory Death.

Transplant Proc 2019 Mar 29;51(2):337-340. Epub 2018 Oct 29.

Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Introduction: Our study compares 2 immunosuppressive strategies to reduce tacrolimus nephrotoxicity and its risk of acute tubular necrosis: delayed introduction of tacrolimus plus thymoglobulin vs initial tacrolimus plus basiliximab on the results of kidney transplant (KT) using type-III donation after circulatory death (III-DCD).

Material And Methods: We analyzed all the transplants performed using type-III DCD in our hospital (42 cases). They were distributed in a first stage with delayed tacrolimus (3°-4° day) + thymoglobulin and a second one with initial tacrolimus + basiliximab, with a follow-up of 6 months. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.022DOI Listing
March 2019
1 Read

Static Cold Storage vs Ex Vivo Machine Perfusion: Results From a Comparative Study on Renal Transplant Outcome in a Controlled Donation After Circulatory Death Program.

Transplant Proc 2019 Mar 12;51(2):311-313. Epub 2018 Dec 12.

Service of Nephrology, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.

Introduction: We aimed to evaluate if ex vivo machine perfusion could minimize the negative impact of cold ischemia on those renal grafts obtained from controlled donation after circulatory death (cDCD).

Material And Methods: Prospective observational paired study of kidney transplants from cDCD performed in our center. The kidney from each pair preserved on ice was transplanted first within the first few hours following procurement, while the contralateral kidney was machine-perfused with a LifePort device (Organ Recovery Systems, Brussels, Belgium) and transplanted the following day. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.010DOI Listing

A simple score can identify kidney transplants recipients at high risk of severe infection over the following two years.

Transpl Infect Dis 2019 Mar 15:e13076. Epub 2019 Mar 15.

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University and Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia, 3168.

Background: The aim of this study was to determine whether a composite score of simple immune biomarkers and clinical characteristics could predict severe infections in kidney transplant recipients.

Methods: We conducted a prospective study of 168 stable kidney transplant recipients who underwent measurement of lymphocyte subsets, immunoglobulins and renal function at baseline and were followed for two years for the development of any severe infections, defined as infection requiring hospitalization. A point score was developed to predict severe infection based on logistic regression analysis of factors in baseline testing. Read More

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http://dx.doi.org/10.1111/tid.13076DOI Listing

Evaluation of outcomes in renal transplantation with hypothermic machine perfusion for the preservation of kidneys from expanded criteria donors.

Clin Transplant 2019 Mar 14:e13536. Epub 2019 Mar 14.

Agence de la Biomédecine, Direction Prélèvement Greffe Organes-Tissus, Saint-Denis La Plaine, France.

In 2012, an expert working group from the French Transplant Health Authority recommended the use of hypothermic machine perfusion (HMP) to improve kidney preservation and transplant outcomes from expanded criteria donors, deceased after brain death. This study compares HMP and cold storage (CS) effects on delayed graft function (DGF) and transplant outcomes. We identified 4,316 kidney transplants from expanded criteria donors (2011-2014) in France through the French Transplant Registry. Read More

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http://dx.doi.org/10.1111/ctr.13536DOI Listing

Expanding the donor pool in kidney transplantation: Should organs with acute kidney injury be accepted?-A retrospective study.

PLoS One 2019 13;14(3):e0213608. Epub 2019 Mar 13.

Department of Internal Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital Münster, Münster, Germany.

Background: Given the gap between patients in need of a renal transplantation (RTx) and organs available, transplantation centers increasingly accept organs of suboptimal quality, e.g. from donors with acute kidney injury (AKI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213608PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415810PMC
March 2019
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A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation.

Nat Commun 2019 03 11;10(1):1157. Epub 2019 Mar 11.

Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA.

The mechanisms initiating late immune responses to an allograft are poorly understood. Here we show, via transcriptome analysis of serial protocol biopsies from kidney transplants, that the initial responses to kidney injury correlate with a late B lymphocyte signature relating to renal dysfunction and fibrosis. With a potential link between dysfunctional repair and immunoreactivity, we investigate the immunological consequences of dysfunctional repair examining chronic disease in mouse kidneys 18 months after a bilateral ischemia/reperfusion injury event. Read More

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http://dx.doi.org/10.1038/s41467-019-09092-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411919PMC
March 2019
2 Reads

Clinical-pathological Correlations in Post-Transplant Thrombotic Microangiopathy.

Histopathology 2019 Mar 9. Epub 2019 Mar 9.

Imperial College, Faculty of Medicine, London, UK.

Aims: Post-transplant thrombotic microangiopathy (TMA) is a rare and clinically challenging finding in renal transplant biopsies. In addition to recurrent atypical haemolytic uremic syndrome (aHUS), TMA in renal transplants is associated with various conditions, such as calcineurin-inhibitor (CNI) treatment, antibody-mediated rejection (ABMR), viral infections, sepsis, pregnancy, malignancies or surgery. The therapeutic implications of this diagnosis are considerable. Read More

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http://dx.doi.org/10.1111/his.13855DOI Listing
March 2019
1 Read

Deep vein thrombosis during long-term surveillance of patients with liver transplantation.

Authors:
Alice Balaceanu

Ir J Med Sci 2019 Mar 8. Epub 2019 Mar 8.

Internal Medicine Department, "Sf. Ioan" Clinical Emergency Hospital, "Carol Davila" University of Medicine and Pharmacy, Sos. Vitan-Bârzești nr. 13, Bucharest, Romania.

Background: In the European Liver Transplant Registry, there are 137,863 liver transplantations recorded. Forty-one percent of patients survived 20 years after liver transplantation in the European countries. From 1988, when the US database for liver transplantation was created, to 2006, there are more than 56,000 liver transplants. Read More

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http://dx.doi.org/10.1007/s11845-019-01998-6DOI Listing

The role of B cell immunity in VCA graft rejection and acceptance.

Hum Immunol 2019 Mar 2. Epub 2019 Mar 2.

Transplantation Biology, Dept Microbiology & Immunology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, United States.

Vascularized composite allotransplantation (VCA) has emerged as the most recent field of transplantation to offer an alternative treatment for those patients that have failed or are not suitable candidates for conventional therapy. Most of the current clinical experience in this field is with recipients of skin containing grafts such as the face, upper extremity and abdominal wall transplants. Like solid organ recipients, VCA recipients require lifelong systematic immunosuppression to maintain their grafts. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.03.002DOI Listing
March 2019
1 Read

[Scedosporium apiospermum infection in a kidney transplant recipient].

Rev Iberoam Micol 2019 Jan - Mar;36(1):48-50. Epub 2019 Mar 1.

Servicio Nefrología, Complejo Hospitalario Universitario de Albacete, Albacete, España.

Background: Emerging fungi infections, although being not the most frequent, are a cause of major morbidity and mortality in recipients of solid organ transplants. The infections caused by the fungi Scedosporium apiospermum are a paradigmatic example of these.

Case Report: We present the clinical case of a 55 year-old female kidney transplant recipient that got infected with S. Read More

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http://dx.doi.org/10.1016/j.riam.2018.10.005DOI Listing
March 2019
2 Reads

Assessment of treatment efficacy using surface-enhanced Raman spectroscopy analysis of urine in rats with kidney transplantation or kidney disease.

Clin Exp Nephrol 2019 Mar 4. Epub 2019 Mar 4.

Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, V6H 3Z6, Canada.

Background: Individuals who have kidney disease or kidney transplants need routine assessment of their kidney damage and function, which are largely measured based on histological examination of kidney biopsies, blood test, and urinalysis. These methods are practically difficult or inconvenient, and expensive. The objective of this study was to develop a model to estimate the kidney damage and function by surface-enhanced Raman spectroscopy (SERS). Read More

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http://link.springer.com/10.1007/s10157-019-01721-w
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http://dx.doi.org/10.1007/s10157-019-01721-wDOI Listing
March 2019
6 Reads

Outcomes From Brain Death Donors With Previous Cardiac Arrest Accepted for Pancreas Transplantation: A Single-center Retrospective Analysis.

Ann Surg 2019 Feb 8. Epub 2019 Feb 8.

Renal Transplant Unit, Nephrology and Kidney Transplant Department, Hospital Clinic, Barcelona, Spain.

Objective: The aim of the study was to evaluate the effect of cardiac arrest time (CAT) in donors after brain death (DBD) donors on pancreas transplant outcome.

Summary Of Background Data: Results from donors after circulatory death report good outcomes despite warm ischemia times up to 57 minutes. Previous cardiac arrest in DBD has been addressed as a potential risk factor, but duration of the CAT has never been evaluated. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003218DOI Listing
February 2019
9 Reads

Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.

Cell Death Dis 2019 Feb 27;10(3):201. Epub 2019 Feb 27.

IRCCS, Regina Elena National Cancer Institute, Rome, Italy.

The pressure towards innovation and creation of new model systems in regenerative medicine and cancer research has fostered the development of novel potential therapeutic applications. Kidney injuries provoke a high request of organ transplants making it the most demanding system in the field of regenerative medicine. Furthermore, renal cancer frequently threaten patients' life and aggressive forms still remain difficult to treat. Read More

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http://dx.doi.org/10.1038/s41419-019-1453-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393468PMC
February 2019
6 Reads

Prevalence of Intestinal Parasitic Infection in Cancer, Organ Transplant and Primary Immunodeficiency Patients in Tehran, Iran

Asian Pac J Cancer Prev 2019 Feb 26;20(2):495-501. Epub 2019 Feb 26.

Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. Email:

Background: Intestinal parasitic infection in immunodeficient patients especially those with impaired cellular immunity, like neoplasia, renal or heart transplant needs careful consideration. The objective of this study is to evaluate the prevalence of intestinal parasites in different group of patients including cancer patients; organ transplants recipients, and primary immunodeficiency patients. Methods: Stool samples from 190 patients including 80 patients with Primary Immunodeficiency, 85 cancer patients and 25 organ transplant recipients were collected; a direct examination with Phosphate buffered saline (PBS) and formalin ether concentration was performed. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.495DOI Listing
February 2019
1 Read

The impact of changing practice on improved outcomes of paediatric renal transplantation in the United Kingdom: a 25 years review.

Transpl Int 2019 Feb 23. Epub 2019 Feb 23.

Children's Renal Unit, Bristol Royal Hospital for Children, Bristol, UK.

This review reports the outcomes of paediatric renal transplantation in the United Kingdom over the last 25 years. UK Transplant Registry data on 3236 paediatric renal transplants performed between 1 January 1992 and 31 December 2016 were analysed. Significant improvements in human leucocyte antigen (HLA) matching have been achieved; 84% of recipients received 000 or favourable (0 DR and 0 or 1 B) mismatched kidneys in 2016 compared with 27% in 1992. Read More

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http://dx.doi.org/10.1111/tri.13418DOI Listing
February 2019
2 Reads
2.599 Impact Factor

Safety of Everolimus With Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplants: An Analysis From the Randomized TRANSFORM Study.

Transplantation 2019 Feb 19. Epub 2019 Feb 19.

Renal Medicine, Royal Prince Alfred Hospital and University of Sydney, Australia.

Background: The safety profiles of standard therapy versus everolimus with reduced-exposure calcineurin inhibitor (CNI) therapy using contemporary protocols in de novo kidney transplant recipients have not been compared in detail.

Methods: TRANSFORM was a randomized, international trial in which de novo kidney transplant patients were randomized to everolimus with reduced-exposure CNI (N=1014) or mycophenolic acid (MPA) with standard-exposure CNI (N=1012), both with induction and corticosteroids.

Results: Within the safety population (everolimus 1014, MPA 1012), adverse events with a suspected relation to study drug occurred in 62. Read More

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http://dx.doi.org/10.1097/TP.0000000000002626DOI Listing
February 2019
3 Reads
3.828 Impact Factor

Twenty Year Follow Up of Histocompatibility Leukocyte Antigen-Matched Kidney and Bone Marrow Co-Transplantation for Multiple Myeloma with End Stage Renal Disease: Lessons Learned.

Transplantation 2019 Feb 12. Epub 2019 Feb 12.

Transplantation Unit, Department of Surgery.

Background: Specific immune tolerance of transplanted organs in association with either transient or sustained lymphohematopoietic chimerism has been demonstrated in several preclinical animal models and clinically, in patients who are full donor chimeras after hematopoietic stem cell transplantation and subsequently received kidney transplants from the same donor. Most recently, tolerance induction has been extended to patients in whom chimerism was intentionally induced at the time of kidney transplantation.

Methods: Twenty years ago, we reported the first successful HLA-matched sibling donor bone marrow and kidney transplant following non-myeloablative conditioning in a patient with multiple myeloma and end stage renal disease. Read More

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http://dx.doi.org/10.1097/TP.0000000000002669DOI Listing
February 2019
3 Reads

miR-483-5p Targets MKNK1 to Suppress Wilms' Tumor Cell Proliferation and Apoptosis In Vitro and In Vivo.

Med Sci Monit 2019 Feb 24;25:1459-1468. Epub 2019 Feb 24.

Department of Rheumatology and Immune Disease, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China (mainland).

BACKGROUND Wilms' tumor (WT) is the most common type of renal tumor in children and it has high mortality rates. MicroRNAs (miRNAs) are important regulators of cellular differentiation processes that have been discovered to contribute to the development of various kinds of tumors. MATERIAL AND METHODS The Wilms' tumor tissues and adjacent tissues were obtained from 28 patients to quantity miR-483-5p expression level. Read More

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http://dx.doi.org/10.12659/MSM.913005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398281PMC
February 2019
5 Reads

The association between socioeconomic disadvantage and parent-rated health in children and adolescents with chronic kidney disease-the Kids with CKD (KCAD) study.

Pediatr Nephrol 2019 Feb 20. Epub 2019 Feb 20.

Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Objective: To determine the association of socioeconomic disadvantage and parent-rated health in children with chronic kidney disease (CKD).

Methods: A total of 377 children (aged 6-18 years) with CKD stages I-V (n = 199), on dialysis (n = 43), or with a kidney transplant (n = 135) were recruited from 2012 to 2016 in Australia and New Zealand. Associations of five socioeconomic status (SES) components and the global SES index with parent-rated health of the child were examined using adjusted logistic regression. Read More

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http://dx.doi.org/10.1007/s00467-019-04209-7DOI Listing
February 2019
3 Reads

Development and evaluation of dedicated low clearance transplant clinics for patients with failing kidney transplants.

J Ren Care 2019 Mar;45(1):51-58

University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.

Background: Recipients with failing kidney transplants (RFKTs) may receive sub-optimal care compared with patients with native kidney disease. The aim of this study is to compare the outcomes of RFKTs managed in a dedicated low clearance transplant clinic (LCTC) compared with those attending a general transplant clinic.

Methods: We undertook a retrospective analysis of patients with failing kidney transplants comparing two clinics-a LCTC versus a general transplant clinic. Read More

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http://dx.doi.org/10.1111/jorc.12268DOI Listing
March 2019
1 Read

Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient.

Pediatr Transplant 2019 Feb 18:e13370. Epub 2019 Feb 18.

Section of Hematology, Oncology and BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Read More

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http://dx.doi.org/10.1111/petr.13370DOI Listing
February 2019
1 Read

Emergency Department Visits After Kidney, Liver, and Heart Transplantation in a Hospital of a University in Turkey: A Retrospective Study.

Exp Clin Transplant 2019 01;17(Suppl 1):264-269

From the Department of Public Health, Baskent University, Ankara, Turkey.

Objectives: In our country, there are few publications evaluating emergency department visits among kidney, liver, and heart transplant recipients. Here, we examined emergency department visits of transplant recipients after initial hospital discharge following organ transplant performed in a medical faculty hospital in Ankara, Turkey.

Materials And Methods: We retrospectively analyzed hospital records of 1144 transplant recipients (700 kidney, 332 liver, and 112 heart) who underwent living-donor and deceased-donor organ transplant procedures in a university hospital between 2007 and 2017 and were admitted to the emergency department during the same period. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P120DOI Listing
January 2019
2 Reads

Onset of Hypertension in Living Kidney Donors After Donor Nephrectomy: Our 20 Years of Experience.

Exp Clin Transplant 2019 01;17(Suppl 1):156-158

From the Department of Nephrology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Objectives: The development of hypertension can negatively affect cardiovascular and renal outcomes in renal kidney donors. Here, we retrospectively investigated the frequency and risk factors of hypertension development in healthy renal donors at our center.

Materials And Methods: Living donors of kidney transplants performed between January 1998 and December 2016 were evaluated. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P32DOI Listing
January 2019
1 Read

Elderly Kidney Transplant Recipients: Single-Center Experience in the Middle East.

Exp Clin Transplant 2019 01;17(Suppl 1):135-141

From Hamed Elessa Organ Transplant Center, Kuwait; and the Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Objectives: The number of renal transplants in elderly patients is increasing as age per se does not constitute a contraindication to transplant. We compared renal transplant outcomes in elderly recipients versus a group of middle-aged patients.

Materials And Methods: Our retrospective casecontrolled study compared elderly transplant recipients (n = 252; > 60 y old) with a matched cohort of younger adult recipients (n = 710; between 40 and 60 years old) who underwent renal transplant at the Hamed Al-Essa Organ Transplant Center of Kuwait between 2000 and 2014. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P6DOI Listing
January 2019
3 Reads

Living-Donor Kidney Transplant With Preformed Donor-Specific Antibodies.

Exp Clin Transplant 2019 01;17(Suppl 1):43-49

From the Department of Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan.

Objectives: We investigated outcomes in living-donor kidney transplant recipients with preformed donor-specific antibodies (detected with flow cytometry and specified with the LABScreen single antigen test) under desensitization pretransplant and immunosuppression posttransplant.

Materials And Methods: Of 15 recipients included, 8 had ABO-incompatible kidney transplant. Six patients had sensitization caused by pregnancy, 8 by blood transfusion, 5 by previous transplants, and 1 by unknown cause. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.L42DOI Listing
January 2019
1 Read

Immune response to non-HLA antigens and renal allograft loss.

Authors:
Stanley C Jordan

Lancet 2019 03 14;393(10174):854-856. Epub 2019 Feb 14.

Comprehensive Transplant Center, Cedars-Sinai Medical Center, West Hollywood, CA 90048, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183318
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http://dx.doi.org/10.1016/S0140-6736(18)33186-6DOI Listing
March 2019
5 Reads

Overall and Site-Specific Cancer Mortality in Patients on Dialysis and after Kidney Transplant.

J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

School of Public Health, University of Sydney, Sydney, Australia.

Patients with ESRD have a substantially increased cancer risk, but few studies have examined the patterns of cancer mortality along a patient's journey from dialysis to transplantation.

Methods: We identified all Australian patients on dialysis and patients with transplants from 1980 to 2014 from the Australia and New Zealand Dialysis and Transplant Registry. Using standardized mortality ratios (SMRs), we compared cancer mortality among patients on dialysis and patients with transplants versus the general population (overall and by age, sex, year, and site); we also performed a subgroup analysis excluding patients with preexisting cancers. Read More

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http://dx.doi.org/10.1681/ASN.2018090906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405152PMC
February 2019
30 Reads
9.343 Impact Factor

Recommendations for ultrasonographic assessment of renal arteries.

J Ultrason 2018 ;18(75):338-343

Department of General Surgery and Endocrinology, Medical University of Warsaw , Poland.

The present clinical practice recommendations are addressed to physicians of all specialties, who perform Doppler ultrasound examinations of the kidneys on a daily basis, and in particular to specialists in radiology and imaging diagnostics. The recommendations were based on the Ultrasonography Standards of the Polish Ultrasound Society and current scientific reports consistent with Evidence Based Medicine. The paper discusses patient preparation protocol, examinat ion technique with particular emphasis on patient's position allowing to obtain proper Doppler angle of insonation, as well as diagnostic limitations of the technique. Read More

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http://dx.doi.org/10.15557/JoU.2018.0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444320PMC
January 2018
9 Reads