10,314 results match your criteria Transplants Renal


The association between socioeconomic disadvantage and parent-rated health in children and adolescents with chronic kidney disease-the Kids with CKD (KCAD) study.

Pediatr Nephrol 2019 Feb 20. Epub 2019 Feb 20.

Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Objective: To determine the association of socioeconomic disadvantage and parent-rated health in children with chronic kidney disease (CKD).

Methods: A total of 377 children (aged 6-18 years) with CKD stages I-V (n = 199), on dialysis (n = 43), or with a kidney transplant (n = 135) were recruited from 2012 to 2016 in Australia and New Zealand. Associations of five socioeconomic status (SES) components and the global SES index with parent-rated health of the child were examined using adjusted logistic regression. Read More

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http://dx.doi.org/10.1007/s00467-019-04209-7DOI Listing
February 2019

Development and evaluation of dedicated low clearance transplant clinics for patients with failing kidney transplants.

J Ren Care 2019 Mar;45(1):51-58

University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.

Background: Recipients with failing kidney transplants (RFKTs) may receive sub-optimal care compared with patients with native kidney disease. The aim of this study is to compare the outcomes of RFKTs managed in a dedicated low clearance transplant clinic (LCTC) compared with those attending a general transplant clinic.

Methods: We undertook a retrospective analysis of patients with failing kidney transplants comparing two clinics-a LCTC versus a general transplant clinic. Read More

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http://dx.doi.org/10.1111/jorc.12268DOI Listing

Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient.

Pediatr Transplant 2019 Feb 18:e13370. Epub 2019 Feb 18.

Section of Hematology, Oncology and BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Read More

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http://dx.doi.org/10.1111/petr.13370DOI Listing
February 2019

Characterization of Early Hepatic Injury in HCV-Negative Recipients of HCV-Infected Kidneys.

Clin Transplant 2019 Feb 19:e13494. Epub 2019 Feb 19.

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, Philadelphia, PA.

Recent data demonstrate that transplanting kidneys from hepatitis C virus (HCV)-infected donors could increase the number of kidney transplants (KT) by 500-1,000 per year with durable cure rates and excellent 1-year renal function. However, data on the risks of acute donor-derived HCV are limited, hampering our ability to inform patients and providers. We sought to examine data from a trial of transplanting HCV-negative patients with kidneys from HCV-infected donors (THINKER, NCT #02743897) to determine whether these recipients had a greater likelihood of having early alanine aminotransferase (ALT) elevations versus comparator recipients of kidneys from HCV-negative donors. Read More

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http://dx.doi.org/10.1111/ctr.13494DOI Listing
February 2019

Emergency Department Visits After Kidney, Liver, and Heart Transplantation in a Hospital of a University in Turkey: A Retrospective Study.

Exp Clin Transplant 2019 Jan;17(Suppl 1):264-269

From the Department of Public Health, Baskent University, Ankara, Turkey.

Objectives: In our country, there are few publications evaluating emergency department visits among kidney, liver, and heart transplant recipients. Here, we examined emergency department visits of transplant recipients after initial hospital discharge following organ transplant performed in a medical faculty hospital in Ankara, Turkey.

Materials And Methods: We retrospectively analyzed hospital records of 1144 transplant recipients (700 kidney, 332 liver, and 112 heart) who underwent living-donor and deceased-donor organ transplant procedures in a university hospital between 2007 and 2017 and were admitted to the emergency department during the same period. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P120DOI Listing
January 2019

Onset of Hypertension in Living Kidney Donors After Donor Nephrectomy: Our 20 Years of Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):156-158

From the Department of Nephrology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Objectives: The development of hypertension can negatively affect cardiovascular and renal outcomes in renal kidney donors. Here, we retrospectively investigated the frequency and risk factors of hypertension development in healthy renal donors at our center.

Materials And Methods: Living donors of kidney transplants performed between January 1998 and December 2016 were evaluated. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P32DOI Listing
January 2019

Elderly Kidney Transplant Recipients: Single-Center Experience in the Middle East.

Exp Clin Transplant 2019 Jan;17(Suppl 1):135-141

From Hamed Elessa Organ Transplant Center, Kuwait; and the Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Objectives: The number of renal transplants in elderly patients is increasing as age per se does not constitute a contraindication to transplant. We compared renal transplant outcomes in elderly recipients versus a group of middle-aged patients.

Materials And Methods: Our retrospective casecontrolled study compared elderly transplant recipients (n = 252; > 60 y old) with a matched cohort of younger adult recipients (n = 710; between 40 and 60 years old) who underwent renal transplant at the Hamed Al-Essa Organ Transplant Center of Kuwait between 2000 and 2014. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P6DOI Listing
January 2019

Living-Donor Kidney Transplant With Preformed Donor-Specific Antibodies.

Exp Clin Transplant 2019 Jan;17(Suppl 1):43-49

From the Department of Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan.

Objectives: We investigated outcomes in living-donor kidney transplant recipients with preformed donor-specific antibodies (detected with flow cytometry and specified with the LABScreen single antigen test) under desensitization pretransplant and immunosuppression posttransplant.

Materials And Methods: Of 15 recipients included, 8 had ABO-incompatible kidney transplant. Six patients had sensitization caused by pregnancy, 8 by blood transfusion, 5 by previous transplants, and 1 by unknown cause. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.L42DOI Listing
January 2019

Overall and Site-Specific Cancer Mortality in Patients on Dialysis and after Kidney Transplant.

J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

School of Public Health, University of Sydney, Sydney, Australia.

Patients with ESRD have a substantially increased cancer risk, but few studies have examined the patterns of cancer mortality along a patient's journey from dialysis to transplantation.

Methods: We identified all Australian patients on dialysis and patients with transplants from 1980 to 2014 from the Australia and New Zealand Dialysis and Transplant Registry. Using standardized mortality ratios (SMRs), we compared cancer mortality among patients on dialysis and patients with transplants versus the general population (overall and by age, sex, year, and site); we also performed a subgroup analysis excluding patients with preexisting cancers. Read More

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http://dx.doi.org/10.1681/ASN.2018090906DOI Listing
February 2019
2 Reads
9.343 Impact Factor

Recommendations for ultrasonographic assessment of renal arteries.

J Ultrason 2018 ;18(75):338-343

Department of General Surgery and Endocrinology, Medical University of Warsaw , Poland.

The present clinical practice recommendations are addressed to physicians of all specialties, who perform Doppler ultrasound examinations of the kidneys on a daily basis, and in particular to specialists in radiology and imaging diagnostics. The recommendations were based on the Ultrasonography Standards of the Polish Ultrasound Society and current scientific reports consistent with Evidence Based Medicine. The paper discusses patient preparation protocol, examinat ion technique with particular emphasis on patient's position allowing to obtain proper Doppler angle of insonation, as well as diagnostic limitations of the technique. Read More

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http://dx.doi.org/10.15557/JoU.2018.0049DOI Listing
January 2018
1 Read

Kidney transplantation epidemiology in Brazil.

Nefrologia 2019 Feb 8. Epub 2019 Feb 8.

Postgraduate Program in Biosciences and Health, State University of Western Paraná, Cascavel, PR, Brazil; Medicine Department, State University of Western Paraná, Cascavel, PR, Brazil.

Background: In 2015, were celebrated in Brazil 50 years of kidney transplants, whose activities have been registered since 1995 by the Brazilian Association of Organ Transplantation (ABTO).

Purpose: To evaluate the quantitative evolution of renal transplants that occurred in Brazil during the period from 1995 to 2015 and to classify the country's position in the international scenario.

Methods: Ecological and retrospective study, based on data records published by ABTO and the International Registry in Organ Donation and Transplantation (IRODaT). Read More

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http://dx.doi.org/10.1016/j.nefro.2018.07.005DOI Listing
February 2019

Tacrolimus Variability: A Cause of Donor-Specific Anti-HLA Antibody Formation in Children.

Eur J Drug Metab Pharmacokinet 2019 Feb 8. Epub 2019 Feb 8.

Department of Pediatric Nephrology, School of Medicine, Akdeniz University, 07059, Antalya, Turkey.

Background And Objectives: The most important determinant of long-term graft survival in renal transplantation is adequate immunosuppression. Inadequate immunosuppression may lead to graft loss due to the presence of anti-HLA antibody. The aim of this study was to investigate the effect of variability in tacrolimus blood concentration on anti-HLA antibody development in pediatric recipients of living-donor renal transplants. Read More

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http://dx.doi.org/10.1007/s13318-019-00544-0DOI Listing
February 2019
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A comparison of post-transplant renal function in pre-emptive and post-dialysis pediatric kidney transplant recipients.

Pediatr Transplant 2019 Feb 8:e13377. Epub 2019 Feb 8.

Division of Urology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: Little is known regarding post-transplant renal function following pediatric pre-emptive KT. Therefore, this study aims to determine whether there is a difference in 1 year post-transplant renal function outcomes between pre-emptive and post-dialysis KT in pediatric transplant recipients.

Methods: A retrospective review of patients who underwent kidney transplant at our institution between 2000 and 2015 was performed. Read More

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http://dx.doi.org/10.1111/petr.13377DOI Listing
February 2019
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"Inverted" positioning of renal allograft during kidney transplantation in children and adolescents: A single-institution comparative analysis.

Pediatr Transplant 2019 Feb 7:e13365. Epub 2019 Feb 7.

Department of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.

Renal transplantation is the treatment of choice in children with end-stage renal failure. Limitations in patient anatomy or a short donor renal vein may necessitate intraoperative inversion of the kidney. There is little evidence to support the use of this surgical technique, and no evidence in the pediatric population. Read More

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http://dx.doi.org/10.1111/petr.13365DOI Listing
February 2019

Leveraging marginal structural modeling with Cox regression to assess the survival benefit of accepting versus declining kidney allograft offers.

Am J Transplant 2019 Feb 6. Epub 2019 Feb 6.

Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Existing studies evaluating the survival benefit of kidney transplantation were unable to incorporate time-updated information on decisions related to each organ offer. We used national registry data, including organ turn-down data, to evaluate the survival benefit of accepting vs. turning down kidney offers in candidates waitlisted from 2007-2013. Read More

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http://dx.doi.org/10.1111/ajt.15290DOI Listing
February 2019
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Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology and Kidney Transplantation, Beaumont Hospital Dublin, Ireland.

Importance: Existing data suggest that nonmelanoma skin cancer (NMSC) is more common in renal transplant recipients than in maintenance dialysis patients. However, whether the risk of NMSC varies as the treatment modality for end-stage kidney disease (ESKD) changes between dialysis and transplantation is not well described.

Objective: To determine whether the incidence of NMSC is attenuated during periods of graft loss with a return to dialysis in those who receive multiple kidney transplants. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4660DOI Listing
February 2019
1 Read

Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation.

Sci Rep 2019 Feb 4;9(1):1172. Epub 2019 Feb 4.

Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan.

The kidney possesses a highly organised vasculature that is required for its filtration function. While recent advances in stem cell biology have enabled the in vitro generation of kidney tissues, at least partially, recapitulation of the complicated vascular architecture remains a huge challenge. Herein we develop a method to reconstitute both the kidney and its vascular architecture in vitro, using dissociated and sorted mouse embryonic kidney cells. Read More

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http://dx.doi.org/10.1038/s41598-018-37793-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362047PMC
February 2019
2 Reads

De novo leukocyte chemotactic factor 2 amyloidosis in a pediatric renal allograft, 15 years post-transplant.

Pediatr Transplant 2019 Feb 3:e13371. Epub 2019 Feb 3.

Department of Pathology, University of California San Francisco, San Francisco, California.

Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a recently described form of systemic amyloidosis, which most commonly affects the kidney and liver. The LECT2 protein is produced during inflammatory processes, but its precise function in renal diseases in unclear. ALECT2, however, is known to be a relatively common form of renal amyloidosis, after amyloid light chain and serum amyloid A types and is most often seen in patients of Hispanic ethnicity. Read More

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http://dx.doi.org/10.1111/petr.13371DOI Listing
February 2019

Effect of Polyoma viremia on three-year allograft kidney function.

Transpl Infect Dis 2019 Feb 3:e13056. Epub 2019 Feb 3.

Renal Transplantation Service - Division of Urology.

Background: Polyoma viremia is associated with damage to renal tubular and urothelial cells. This may imply that a certain level of viremia, even cleared thereafter, could be associated with long-term renal dysfunction.

Methods: We, retrospectively, analyzed 390 first renal transplants adult recipients (≥18y) who were monitored for BK viremia in the first 12 months and evaluated estimated GFR (MDRD-4 equation) at one month and at the last follow-up (959±392 days). Read More

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http://dx.doi.org/10.1111/tid.13056DOI Listing
February 2019
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Outcomes of kidney transplant from deceased donors with acute kidney injury and prolonged cold ischemia time.

Transpl Int 2019 Feb 3. Epub 2019 Feb 3.

Department of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, NY.

While deceased donor renal transplants (DDRT) from donors with either acute kidney injury (AKI) or long cold ischemia time (CIT) are associated with increased risk of delayed graft function (DGF), recipients of these kidneys have good patient and allograft survival. There are limited data on whether kidneys with both AKI and long CIT have outcomes similar to kidneys with only one of these insults. Using data from the Scientific Registry of Transplant Recipients, we analyzed transplant outcomes in patients (2005-2015) receiving kidneys with AKI (terminal creatinine ≥2. Read More

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http://dx.doi.org/10.1111/tri.13406DOI Listing
February 2019
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"Real-time" risk models of postoperative morbidity and mortality for liver transplants.

Ann Gastroenterol Surg 2019 Jan 2;3(1):75-95. Epub 2018 Nov 2.

Japanese Society of Gastroenterological Surgery Tokyo Japan.

Aim: A comprehensive description of morbidity and mortality risk factors for post liver transplant has not been available to date. In this study, we established real-time risk models of postoperative morbidities and mortality in liver transplant recipients using two Japanese nationwide databases.

Methods: Data from two Japanese nationwide databases were combined and used for this study. Read More

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http://dx.doi.org/10.1002/ags3.12217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345648PMC
January 2019

High-Intensity Focused Ultrasonography and Radiofrequency Ablation of Renal Cell Carcinoma Arisen in Transplanted Kidneys: Single-Center Experience With Long-Term Follow-Up and Review of Literature.

J Ultrasound Med 2019 Jan 28. Epub 2019 Jan 28.

EndoCAS (Center for Computer Assisted Surgery), University of Pisa, Pisa, Italy.

The purpose of this article is to retrospectively evaluate the long-term outcome of patients treated with percutaneous thermoablation for renal cell carcinomas that have arisen in kidney grafts. Between April 2008 and February 2011, we treated 3 patients with renal cell carcinoma on a transplanted kidney: 2 cases were treated with high-intensity focused ultrasonography and 1 patient with radio frequency ablation. Postprocedural ultrasonography did not reveal any complications, and contrast-enhanced ultrasonography showed an avascular area in the treated nodules. Read More

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http://dx.doi.org/10.1002/jum.14938DOI Listing
January 2019

Outcomes and challenges of a kidney transplant programme at Groote Schuur Hospital, Cape Town: A South African perspective.

PLoS One 2019 25;14(1):e0211189. Epub 2019 Jan 25.

Department of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.

Introduction: Access to dialysis and transplantation in the developing world remains limited. Therefore, optimising renal allograft survival is essential. This study aimed to evaluate clinical outcomes and identify poor prognostic factors in the renal transplant programme at Groote Schuur Hospital [GSH], Cape Town. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211189PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347365PMC
January 2019

Elevated Donor Hemoglobin A1C Impairs Kidney Graft Survival From Deceased Donors With Diabetes Mellitus: A National Analysis.

Exp Clin Transplant 2019 Jan 21. Epub 2019 Jan 21.

From the Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Objectives: Kidney transplant is the optimal therapy for patients with end-stage renal disease. The presence of donor diabetes mellitus is a recognized risk factor for impaired kidney graft survival and is incorporated into the Kidney Donor Profile Index. At present, however, there are limited assessments of the severity of this risk factor. Read More

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http://dx.doi.org/10.6002/ect.2017.0322DOI Listing
January 2019

[LONG-TERM OUTCOME OF PEDIATRIC KIDNEY TRANSPLANTATION: A SINGLE-CENTER EXPERIENCES].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):14-19

Department of Urology, Molecular Oncology, Graduate School of Medical and Dental Sciences, Niigata University.

(Background) Long-term care is necessary for normal growth and development of pediatric recipients of kidney transplants. We report on our experience with pediatric kidney transplantation (KTx) during the past 19 years. (Methods) We retrospectively analyzed the data from 26 recipients who received KTx between 1996 and 2014 at Niigata University Hospital (one patient underwent two consecutive KTx during the designated period). Read More

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https://www.jstage.jst.go.jp/article/jpnjurol/109/1/109_14/_
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http://dx.doi.org/10.5980/jpnjurol.109.14DOI Listing
February 2019
5 Reads

PreImplantation Trial of Histopathology In renal Allografts (PITHIA): a stepped-wedge cluster randomised controlled trial protocol.

BMJ Open 2019 Jan 17;9(1):e026166. Epub 2019 Jan 17.

Department of Surgery, University of Cambridge, Cambridge, UK.

Introduction: Most potential kidney transplant donors in the UK are aged over 60 years, yet increasing donor age is associated with poorer graft survival and function. Urgent preimplantation kidney biopsy can identify chronic injury, and may aid selection of better 'quality' kidneys from this group. However, the impact of biopsy on transplant numbers remains unproven. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02616
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http://dx.doi.org/10.1136/bmjopen-2018-026166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340453PMC
January 2019
9 Reads

Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission.

Transplant Direct 2019 Jan 20;5(1):e416. Epub 2018 Dec 20.

Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL.

In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Read More

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http://Insights.ovid.com/crossref?an=01845228-201901000-0000
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http://dx.doi.org/10.1097/TXD.0000000000000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324914PMC
January 2019
9 Reads

Association of Dialysis Duration With Outcomes After Kidney Transplantation in the Setting of Long Cold Ischemia Time.

Transplant Direct 2019 Jan 17;5(1):e413. Epub 2018 Dec 17.

Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, NY.

Background: There is no mechanism that matches hard-to-place kidneys with the most appropriate candidate. Thus, unwanted kidney offers are typically to recipients with long renal replacement time (vintage) which is a strong risk factor for mortality and graft failure, and in combination with prolonged cold ischemia time (CIT), may promote interactive effects on outcomes.

Methods: Consecutive adult isolated kidney transplants between October 2015 and December 2017 were stratified by vintage younger than 1 year and CIT longer than 30 hours. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324908PMC
January 2019
1 Read

Living Kidney Donation Is Recipient Age Sensitive and Has a High Rate of Donor Organ Disqualifications.

Transplant Proc 2019 Jan - Feb;51(1):120-123. Epub 2018 Jun 30.

Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Background: Living donor kidney transplantation (LDKT) is the best therapy for patients with chronic renal failure. Its advantages, compared with cadaveric transplantation, include the possibility of avoiding dialysis, the likelihood of best outcome, and donor pool expansion. Careful assessment of potential donors is important to minimize the risks and ensure success. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183086
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http://dx.doi.org/10.1016/j.transproceed.2018.03.136DOI Listing
June 2018
7 Reads

Our Timing to Remove Peritoneal Catheter Dialysis After Kidney Transplant.

Transplant Proc 2019 Jan - Feb;51(1):160-163. Epub 2018 Jun 30.

Operative Unit of General Surgery and Kidney Transplantation, Advanced Biomedical Science Department, University Federico II of Naples, Naples, Italy.

Background: Patients on peritoneal dialysis treatment represent 15% of the global dialysis population. The major complication of peritoneal dialysis is catheter and peritoneal infection. Peritoneal dialysis patients who receive kidney transplants are at increased risk of infection because of immunosuppressive therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183085
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http://dx.doi.org/10.1016/j.transproceed.2018.04.075DOI Listing
June 2018
12 Reads

Liver Transplant From Controlled Cardiac Death Donors Using Normothermic Regional Perfusion: Comparison With Liver Transplants From Brain Dead Donors.

Transplant Proc 2019 Jan - Feb;51(1):12-19. Epub 2018 Jun 28.

Department of General Surgery, University Hospital "Marqués de Valdecilla," Santander, Spain.

Background: Liver transplantation from donors after either controlled or uncontrolled cardiac death (DCD) is associated with considerable rates of primary nonfunction (PNF) and ischemic cholangiopathy (IC). Normothermic regional perfusion (NRP) could significantly reduce such rates.

Methods: Retrospective study to analyze short-term (mortality, PNF, vascular complications) and long-term (IC, survival) complications in 11 liver transplants from controlled DCDs using NRP with extracorporeal membrane oxygenation (ECMO) (group 1). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.067DOI Listing
June 2018
6 Reads

Ethical Issues in the Use of Suboptimal Kidneys for Transplants: An Italian Point of View.

Transplant Proc 2019 Jan - Feb;51(1):106-110. Epub 2018 Jun 30.

Operative Unit of General Surgery and Kidney Transplantation, Advanced Biomedical Science Department, University Federico II of Naples, Naples, Italy.

The shortage of organs leads to the need for utilizing suboptimal kidneys for transplantation. The distinction between optimal, marginal, and suboptimal kidneys leads surgeons to face not only technical problems but also ethical and legal issues related to clinical advantages offered by the transplant of a nonstandard kidney and the acquisition of consent. Between 1999 and 2015, we performed 658 transplants, 49 (7. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183085
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http://dx.doi.org/10.1016/j.transproceed.2018.05.031DOI Listing
June 2018
4 Reads

Minimally-Invasive Ureteral Reconstruction for Ureteral Complications of Kidney Transplants.

Urology 2019 Jan 14. Epub 2019 Jan 14.

Lahey Hospital & Medical Center, Burlington, MA.

Objective: To present the technique, feasibility and results of minimally-invasive reconstruction of the transplanted ureter using the native ipsilateral ureter in post-transplant ureteral strictures and vesicoureteral reflux (VUR) causing graft pyelonephritis. Ureteral complications after kidney transplantation represent a significant cause of morbidity potentially leading to graft dysfunction or loss.

Methods: A prospective database from October 2011 to August 2018 identified renal transplant recipients who underwent minimally-invasive pyeloureterostomies or ureteroureterostomies using the ipsilateral ureter. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.002DOI Listing
January 2019
2 Reads

Impact of gender and gender disparities in patients with kidney disease.

Curr Opin Nephrol Hypertens 2019 Mar;28(2):178-182

Department of Medicine, Division of Nephrology, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Purpose Of Review: Despite evidence of gender-specific differences in epidemiology and outcomes in all stages of chronic kidney disease (CKD), most studies ignore the issue of gender. This review addresses this knowledge gap by evaluating data on gender disparity in this population.

Recent Findings: Population-based studies indicate a higher prevalence of CKD in women; however, there are fewer women on renal replacement therapy than men. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000482DOI Listing
March 2019
2 Reads

Postoperative acute kidney injury in lung transplant recipients.

Interact Cardiovasc Thorac Surg 2019 Jan 10. Epub 2019 Jan 10.

Respiratory Diseases and Lung Transplantation Unit, University Hospital of Siena (AOUS), Siena, Italy.

Objectives: Acute kidney injury (AKI) is a common postoperative complication after lung transplantation. The aim of the present study was to evaluate the incidence of AKI in lung transplant patients and its effect on patients and graft outcome in relation to degree of severity.

Methods: Data from 135 patients who underwent lung transplant in the same Italian institution were recorded retrospectively and analysed (69 unilateral and 66 bilateral lung transplants, age 51. Read More

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http://dx.doi.org/10.1093/icvts/ivy355DOI Listing
January 2019
2 Reads

HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival.

FASEB J 2019 Jan 8:fj201802017R. Epub 2019 Jan 8.

Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Human leukocyte antigen G (HLA-G), a nonclassic HLA class Ib molecule involved in the maintenance of maternal tolerance to semiallogeneic fetal tissues during pregnancy, has emerged as a potential therapeutic target to control allograft rejection. We demonstrate here that the level of soluble HLA-G dimer was higher in a group of 90 patients with a functioning renal allograft compared with 40 patients who rejected (RJ) their transplants. The HLA-G dimer level was not affected by demographic status. Read More

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https://www.fasebj.org/doi/10.1096/fj.201802017R
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http://dx.doi.org/10.1096/fj.201802017RDOI Listing
January 2019
13 Reads

Epidemiological and Immunological Characteristics of HIV-Infected Patients on the Cadaveric Kidney Donor Waiting List at the Johannesburg Renal Transplant Program.

AIDS Res Hum Retroviruses 2019 Feb 20. Epub 2019 Feb 20.

5 Department of Immunology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa.

HIV infection was previously considered an exclusion criterion for renal dialysis and transplant. Recent research has prompted policy changes, allowing for transplantation in this subgroup of patients. Theoretical risks with transplantation include the immune dysregulation associated with post-transplantation immunosuppression and immune activation with possible organ rejection. Read More

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http://dx.doi.org/10.1089/AID.2018.0193DOI Listing
February 2019
1 Read

Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants.

Amino Acids 2019 Jan 4. Epub 2019 Jan 4.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Sector A, University of Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy humans. Read More

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http://dx.doi.org/10.1007/s00726-018-02693-zDOI Listing
January 2019

How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Pathology Unit, S. Orsola-Malpighi University Hospital of Bologna, Bologna, Italy.

Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Read More

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http://dx.doi.org/10.1007/s40620-018-00573-zDOI Listing
January 2019

Outcomes of kidney transplants in pediatric patients with the vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities association.

Pediatr Transplant 2019 Mar 30;23(2):e13341. Epub 2018 Dec 30.

Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

In this single-center retrospective study, we analyzed kidney transplant outcomes in nine pediatric patients with VACTERL [vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities] association-making this the largest study of its kind. Of 743 pediatric kidney transplant recipients at our center (1980-2017), nine had documented diagnoses of VACTERL association. All nine had congenital anorectal malformations and renal anomalies, five had vertebral defects, and one had a bifid thumb and tracheoesophageal fistula. Read More

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http://dx.doi.org/10.1111/petr.13341DOI Listing
March 2019
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ABO-incompatible kidney transplantation as a renal replacement therapy-A single low-volume center experience in Japan.

PLoS One 2018 31;13(12):e0208638. Epub 2018 Dec 31.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Introduction: Living donor kidney transplantation is preferable to deceased donor transplantation due to its superior long-term patient and graft survivals. However, ABO blood group incompatibility is a major barrier to living donor kidney transplantation. ABO-incompatible kidney transplantation has been performed in Japan since the late 1980's, but it is still globally uncommon. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208638PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312268PMC
December 2018

Molecular Assessment of C4d-Positive Renal Transplant Biopsies Without Evidence of Rejection.

Kidney Int Rep 2019 Jan 18;4(1):148-158. Epub 2018 Sep 18.

Centre for Inflammatory Diseases, Imperial College, London, UK.

Introduction: Immunohistochemical staining for C4d in peritubular capillaries has been part of antibody-mediated rejection (AbMR) definition in the Banff Classification for Allograft Pathology since 2003. However, it has limited sensitivity and specificity, therefore the clinical significance of C4d-positive biopsies without evidence of rejection (C4d+ WER) is unknown. We investigated the transcript levels of genes associated with AbMR in C4d+ WER biopsies from both ABO-compatible and incompatible renal transplant patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183020
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http://dx.doi.org/10.1016/j.ekir.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308373PMC
January 2019
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Ischemia reperfusion injury in kidney transplantation: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13650

Department of Nephrology, Dialysis and Transplantation, Clermont Ferrand, University Hospital, Clermont Ferrand, France.

Rationale: Kidney transplantation is considered the best treatment for patients with end stage renal disease. Ischemia- reperfusion injury (IRI) is an evitable event after deceased donor transplantation and influences short term and long term graft outcome. Few data on IRI's histology in the setting of kidney transplantation are available in the literature despite its frequency and its severity. Read More

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http://dx.doi.org/10.1097/MD.0000000000013650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314654PMC
December 2018
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A single-center 4-year experience with 47 pediatric renal transplants: Evolving trends.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1303-1310

Department of Surgery, Section of Transplantation, Renal Transplant Unit, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Outcome of pediatric kidney transplantation (KT) has improved over the last several decades. We retrospectively reviewed the outcomes pediatric KT in King Faisal Specialist Hospital and Research Center-Jeddah, Saudi Arabia. Between May 2013 and November 2016, we performed renal transplantation in 47 children, 30 (64%) males, and 17 (36%) females. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1303/248297
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http://dx.doi.org/10.4103/1319-2442.248297DOI Listing
December 2018
7 Reads

Effect of Renal Diagnosis on Survival in Simultaneous Liver-Kidney Transplantation.

J Am Coll Surg 2018 Dec 23. Epub 2018 Dec 23.

Department of Surgery, Division of Abdominal Transplantation, University of Alabama at Birmingham, Birmingham, AL.

Background: Simultaneous liver-kidney transplantation is lifesaving, however, the utility of allocating 2 organs to a single recipient remains controversial, particularly in the face of potentially inferior survival. This study aims to determine the effect of renal indication for transplantation on simultaneous liver-kidney transplantation outcomes.

Methods: All adult recipients of combined whole liver-kidney transplants in the United Network for Organ Sharing database from 2003 to 2016 with a renal diagnosis of hypertension (HTN), diabetes mellitus (DM), acute tubular necrosis (ATN), or hepatorenal syndrome (HRS) were examined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10727515183222
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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.003DOI Listing
December 2018
5 Reads

Recipient Outcomes From Nondirected Live Kidney Donors: A UK-based Cohort Study.

Transplant Direct 2018 Dec 15;4(12):e406. Epub 2018 Nov 15.

Department of Renal Surgery, University Hospital Birmingham, Birmingham, United Kingdom.

Background: Increasing numbers of patients with end-stage renal failure are receiving kidneys from nondirected kidney donors (NKDs), also known as altruistic donors. Transplant outcomes for recipients of such kidneys are largely inferred from studies on specified kidney donors (SKDs), which may be inaccurate due to differences in donor, recipient and transplant specific factors. We report the outcomes for recipients of NKD in the United Kingdom. Read More

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http://Insights.ovid.com/crossref?an=01845228-201812000-0000
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http://dx.doi.org/10.1097/TXD.0000000000000847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283085PMC
December 2018
7 Reads

Use of single-dose perioperative antimicrobial therapy is acceptable in recipients of living-donor renal transplants in the rituximab era.

J Infect Chemother 2018 Dec 21. Epub 2018 Dec 21.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Objective: The aim of this study was to evaluate the efficacy of single-dose perioperative antimicrobial therapy as infection prophylaxis in recipients of living-donor renal transplants in the rituximab era.

Patients And Methods: Between 2009 and 2017, 84 recipients underwent living-donor renal transplantation (LDRT) at Okayama University Hospital; 3 with vascular/urinary complications requiring additional surgery were excluded from this analysis. Data including recipient characteristics, antimicrobial prophylaxis and administration of rituximab were retrospectively examined for an association with perioperative infections. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.11.013DOI Listing
December 2018
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Infrainguinal bypass surgery outcomes are worse in hemodialysis patients compared with patients with renal transplants.

J Vasc Surg 2018 Dec 21. Epub 2018 Dec 21.

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, Md. Electronic address:

Objective: Studies of infrainguinal bypass surgery (IBS) in patients with end-stage renal disease have focused on hemodialysis (HD) patients. Little is known of the applicability of their outcomes to patients with renal transplants (RTs). In this study, we sought to compare perioperative and long-term outcomes of IBS in a large population-based cohort of HD and RT patients. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.05.252DOI Listing
December 2018
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Page Kidney Following a Nonepisode Protocol Renal Allograft Biopsy: A Case Report.

Transplant Proc 2018 Dec 9;50(10):3961-3963. Epub 2018 Aug 9.

Department of Urology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

Page kidney refers to a clinical condition that is characterized by the acute onset of hypertension and renal dysfunction owing to external compression of the kidney by a hematoma, tumor, lymphocele, or urinoma. We report a case in which Page kidney occurred after a nonepisode protocol renal allograft biopsy. A 31-year-old man with end-stage renal disease received a living related kidney transplant from his father. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.08.008DOI Listing
December 2018
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Intra-operative Postperfusion Micronephrolithotomy for Renal Allograft Lithiasis: A Case Report.

Transplant Proc 2018 Dec 29;50(10):3950-3953. Epub 2018 May 29.

Kidney Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address:

Increasing demand drives the expansion of criteria for kidney donation, and nephrolithiasis is now considered a relative contraindication. We report for the first time a case of intra-operative, postperfusion kidney allograft micronephrolithotomy. A 64-year-old man with end-stage renal disease secondary to Alport syndrome underwent primary deceased donor kidney transplantation at our center. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183072
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http://dx.doi.org/10.1016/j.transproceed.2018.05.017DOI Listing
December 2018
7 Reads