7,657 results match your criteria Transplants Liver


Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

Pediatr Transplant 2019 Apr 23:e13420. Epub 2019 Apr 23.

Department of Clinical Hematology, Royal Children's Hospital, Parkville, Victoria, Australia.

Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children post-liver transplant, with comparison to our institution's experience. Read More

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http://dx.doi.org/10.1111/petr.13420DOI Listing

Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report.

Pediatr Transplant 2019 Apr 23:e13410. Epub 2019 Apr 23.

Liver Transplant Program, University of Minnesota Masonic Children's Hospital, University of Minnesota, Minneapolis, Minnesota.

Hepatic angiosarcoma is an extremely rare diagnosis in children, with fewer than 50 pediatric cases reported in the literature worldwide. This aggressive vascular sarcoma carries a very dismal prognosis and is known to be resistant to radiation, chemotherapy, and other vascular-targeted agents. Complete surgical resection is felt to provide the best chance for long-term survival. Read More

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http://dx.doi.org/10.1111/petr.13410DOI Listing

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Transplant Immunology, Department of Pathology & Laboratory Medicine & Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Functions of the GCN5-related N-acetyltransferase (GNAT) family of histone/protein acetyltransferases (HATs) in Foxp3+ T-regulatory (Treg) cells are unexplored, despite the general importance of these enzymes in cell biology. We now show that two prototypical GNAT family members, GCN5 (general control nonrepressed-protein 5, lysine acetyltransferase (KAT)2a) and p300/CBP-associated factor (p300/CBP-associated factor (PCAF), Kat2b) contribute to Treg functions through partially distinct and partially overlapping mechanisms. Deletion of Gcn5 or PCAF did not affect Treg development or suppressive function in vitro, but did affect inducible Treg (iTreg) development, and in vivo, abrogated Treg-dependent allograft survival. Read More

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http://dx.doi.org/10.3390/cancers11040554DOI Listing

Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Massachusetts General Hospital, Institute for Technology Assessment, Harvard Medical School, Boston, MA, USA. Electronic address:

Background & Aims: Early liver transplantation (without requiring a minimum period of sobriety) for severe alcohol-associated hepatitis (AH) is controversial-many centers delay eligibility until a specific period of sobriety (such as 6 months) has been achieved. To inform ongoing debate and policy, we modeled long-term outcomes of early vs delayed liver transplantation for patients with AH.

Methods: We developed a mathematical model to simulate early vs delayed liver transplantation for patients with severe AH and different amounts of alcohol use after transplantation: abstinence, slip (alcohol use followed by sobriety), or sustained use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.012DOI Listing
April 2019
2 Reads

Age Matching of Elderly Liver Grafts With Elderly Recipients Does Not Have a Synergistic Effect on Long-term Outcomes When Both Are Carefully Selected.

Transplant Direct 2019 Apr 26;5(4):e342. Epub 2019 Mar 26.

Department of Microbiology and Immunology, Laboratory of Abdominal Transplant Surgery, KU Leuven, Leuven, Belgium.

Background: Older donors and recipients are increasingly considered for liver transplantation. Both donor and recipient age have a negative impact on outcomes. Large registry analyses show that older donors are frequently matched to older recipients. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445659PMC
April 2019
1 Read

Impact of Model for End-Stage Liver Disease Score Based Allocation System in Korea: A nation-wide study.

Transplantation 2019 Apr 10. Epub 2019 Apr 10.

Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: In June 2016, the Korean Network for Organ Sharing implemented a model for end-stage liver disease (MELD) score-based allocation system to better prioritize deceased donor liver transplant (DDLT) candidates. The aim of this study was to assess the impact of this allocation system.

Methods: We compared waiting list and post-transplant outcomes during the first year of operation of the MELD allocation system (from June 2016 to May 2017) with an equivalent period before its implementation (from June 2015 to May 2016). Read More

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http://dx.doi.org/10.1097/TP.0000000000002755DOI Listing

Evaluation of the Effects of Cultured Bone Marrow Mesenchymal Stem Cell Infusion on Hepatocarcinogenesis in Hepatocarcinogenic Mice With Liver Cirrhosis.

Transplant Proc 2019 Apr;51(3):925-935

Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan; Center for Liver Disease, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Yamaguchi, Japan.

Objectives: Liver transplantation remains the only curative therapy for decompensated liver cirrhosis. However, it has several limitations, and not all patients can receive liver transplants. Therefore, liver regenerative therapy without liver transplantation is considered necessary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345193049
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http://dx.doi.org/10.1016/j.transproceed.2019.03.011DOI Listing
April 2019
1 Read

Liver Donations and Transplants in the State of Paraná, Brazil.

Transplant Proc 2019 Apr 9;51(3):632-638. Epub 2019 Jan 9.

Department of Nursing, State University of Londrina, Londrina, Paraná, Brazil.

Background: The increase in the waiting list for a liver and the high mortality rate of patients with terminal liver disease represent serious public health problems in Brazil.

Objective: To analyze donations and liver transplants in the State of Paraná, Brazil.

Method: A cross-sectional study was carried out with data from 3931 reports of deaths due to brain death and 8146 solid organ transplants made available by the State Transplant System of Paraná between 2011 and 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183131
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http://dx.doi.org/10.1016/j.transproceed.2018.12.031DOI Listing
April 2019
4 Reads

Bi-organ Paired Exchange - Sentinel Case of a Liver-Kidney Swap.

Am J Transplant 2019 Apr 12. Epub 2019 Apr 12.

Connie Frank Transplant Center, Division of Nephrology and Hypertension, Department of Medicine, University of California, San Francisco.

Organ transplantation is the optimal treatment for patients with ESLD and ESRD. However, due to the imbalance in the demand and supply of deceased organs, most transplant centers worldwide have consciously pursued a strategy for living donation. Paired exchanges were introduced as a means to bypass various biologic incompatibilities (blood- and tissue-typing), while expanding the living donor pool. Read More

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http://dx.doi.org/10.1111/ajt.15386DOI Listing
April 2019
5.683 Impact Factor

Aortic Conduit Aneurysm and Enteric Fistula Formation in a Post Liver Transplant Patient: A potential causative role for CMV?

Transpl Infect Dis 2019 Apr 11:e13092. Epub 2019 Apr 11.

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Edgbaston, Birmingham, B15 2GW.

Hepatic arterial aortic conduits can be used as an alternative means of revascularising the donor liver when the native recipient hepatic artery (HA) cannot be used. Cytomegalovirus (CMV) is a common Herpesviridae infection in patients who have undergone solid organ transplants. It can be asymptomatic but may cause fever and invasive disease affecting any organ system. Read More

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http://dx.doi.org/10.1111/tid.13092DOI Listing
April 2019
1 Read

Occult hepatitis B and HIV infection.

Eur J Gastroenterol Hepatol 2019 Apr 8. Epub 2019 Apr 8.

UNIR Health Sciences School.

Introduction: Occult hepatitis B virus (HBV) infection, so-called occult B infection (OBI), is defined by the recognition of HBV-DNA in the absence of serum hepatitis B surface antigen (HBsAg). The HBV-DNA genome in OBI is fully replication competent and produced in the liver, characteristically with low-level HBV-DNA fluctuations in the bloodstream. The OBI status remains between chronic (HBsAg+) and resolved (anti-HBs+) phases in the natural history of HBV infection. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001417DOI Listing
April 2019
2.152 Impact Factor

Human Adipose Derived Stem Cells Exhibit Enhanced Liver Regeneration in Acute Liver Injury by Controlled Releasing Hepatocyte Growth Factor.

Cell Physiol Biochem 2019 ;52(4):935-950

Department of Medicine, College of Medicine, Catholic Kwandong University, Gangneung, South Korea,

Background/aims: Although mesenchymal stem cells (MSCs) provide effective therapy for liver fibrosis, there are conflicting data regarding their marginal therapeutic effects. This study aimed to enhance the potential of hepatocyte regeneration in human adipose mesenchymal stem cells (ASCs) and investigate whether they have robust therapeutic efficacy in experimental liver fibrosis.

Methods: ASCs were cultured with four cytokines (ASC-C), the expression of hepatogenic factors was detected by microarray, and the effects of conditioned medium (CM) from ASC-C on the activation of hepatic stellate cells were analyzed. Read More

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http://dx.doi.org/10.33594/000000065DOI Listing
April 2019
1 Read

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Efficacy and safety of transarterial chemoembolization with 70- to 150-μm drug-eluting beads alone or in combination with 100- to 300-μm drug-eluting beads.

Proc (Bayl Univ Med Cent) 2018 Oct 5;31(4):428-431. Epub 2018 Nov 5.

Department of Radiology, University of FloridaGainesvilleFlorida.

To evaluate the safety and efficacy of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma, a retrospective analysis of patients who underwent TACE utilizing up to one vial of LC BeadM1 (70-150 μm) embolics with doxorubicin was performed. If tumor devascularization was not achieved, up to one additional vial of LC Bead (100-300 μm) embolics with doxorubicin was subsequently administered. Ninety-four sessions of TACE were completed among 48 patients. Read More

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http://dx.doi.org/10.1080/08998280.2018.1499363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413998PMC
October 2018
1 Read

Liver transplantation and allergy: transplant-acquired food allergy.

Psychiatr Danub 2019 Mar;31(Suppl 1):63-65

Department of Anestesiology, Reanimatology and Intensive Care, University Hospital Merkur, Zajčeva 19, 10000 Zagreb, Croatia,

Transplant-acquired food allergy is a well known phenomenon especially linked to liver transplants. Risk factors lie both in transplant recipient and transplant donor - age of recipient and the maturity of immune regulatory mechanisms, family history of atopy in recipient, young age of the donor and atopic history in donor. The exact mechanism has not yet been established and there are many different explanations of this pathophysiologic process. Read More

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March 2019
2 Reads

Postoperative Complications of Plastic and Reconstructive Surgery in Solid Organ Transplant Recipients.

J Craniofac Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Plastic and Reconstructive Surgery, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.

Introduction: As the number of organ transplants and the survival rate increase, solid organ transplant patients will need more plastic and reconstructive surgery. However, such patients take immunosuppressants, including prednisone, which makes wound healing slower and plastic surgeons more hesitate to operate. In this study, we examined postoperative complications of organ transplant patients who have undergone plastic and reconstructive surgery. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005511DOI Listing
March 2019
3 Reads

The microbiome: implications for perioperative and critical care.

Curr Opin Anaesthesiol 2019 Mar 28. Epub 2019 Mar 28.

Division of Digestive and Liver Diseases, Department of Medicine.

Purpose Of Review: The host-microbiota relationship is integral in human health and can be rapidly disrupted in ways that may contribute to poor recovery from surgery or acute illness. We review key studies by organ system to understand the effect of perioperative and critical illness stress on the microbiota. Throughout the review, our focus is on potential interventions that may be mediated by the microbiome. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000734DOI Listing
March 2019
1 Read

Clinical Implications of Donor Warm and Cold Ischemia Time in Donor after Circulatory Death (DCD) Liver Transplantation.

Liver Transpl 2019 Mar 26. Epub 2019 Mar 26.

Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.

The utilization of donor after circulatory death (DCD) liver allografts has been constrained by limitations in the duration of donor warm ischemia time (DWIT), agonal time (DAT), and cold ischemia time (CIT). The purpose of this study is to assess the impact of longer DWIT, DAT, and CIT on graft survival and other outcomes in DCD liver transplants. The Scientific Registry of Transplant Recipients was queried for adult liver transplants from DCD donors between 2009 and 2015. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25453
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http://dx.doi.org/10.1002/lt.25453DOI Listing
March 2019
11 Reads

Antegrade hepatic artery and portal vein perfusion versus portal vein perfusion alone in live donor liver transplantation: a randomized trial.

Liver Transpl 2019 Mar 25. Epub 2019 Mar 25.

Department of Gastrointestinal Surgery & Solid Organ Transplant, Amrita Institute of Medical Sciences & Research Centre, Amrita University, Kochi, Kerala, India, 682041.

Background: Traditionally, deceased donor liver grafts receive dual perfusion through the portal vein and the hepatic artery(HA) either in-situ or on the back-table. Hepatic artery perfusion is avoided in live donor liver grafts for fear of damage to the intima and consequent risk of hepatic artery thrombosis(HAT). However, biliary vasculature is predominantly derived from the HA. Read More

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http://dx.doi.org/10.1002/lt.25455DOI Listing

Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.

J Low Genit Tract Dis 2019 Apr;23(2):87-101

Department of Obstetrics and Gynecology, University of Oklahoma Tulsa, OU-TU School of Community Medicine, Tulsa, OK.

Executive Summary: The risk of cervical cancer (CC) among women immunosuppressed for a variety of reasons is well documented in the literature. Although there is improved organ function, quality of life and life expectancy gained through use of immunosuppressant therapy, there may be increased long-term risk of cervical neoplasia and cancer and the need for more intense screening, surveillance, and management. Although guidance for CC screening among HIV-infected women (see Table 1) has been supported by evidence from retrospective and prospective studies, recommendations for CC screening among non-HIV immunosuppressed women remains limited because quality evidence is lacking. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000468DOI Listing
April 2019
2 Reads

Training in recovery, perfusion and packaging of organs for transplants: profile of professionals and analysis of post-course learning.

Einstein (Sao Paulo) 2019 Mar 18;17(2):eAO4445. Epub 2019 Mar 18.

Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Objective: To understand the profile of professionals working in organ harvesting, and analyze the learning results of those trained before and after the course on recovery, perfusion and packaging of organs for transplants.

Methods: A retroprospective, quantitative, analytical-descriptive study about the Course on Recovery, Perfusion and Packaging of Liver and Kidney, in the period from 2012 to 2014. Pre- and post-tests, with ten questions were used to assess knowledge about organ harvesting. Read More

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https://journal.einstein.br/article/training-in-recovery-per
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http://dx.doi.org/10.31744/einstein_journal/2019AO4445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422361PMC
March 2019
5 Reads

The Changing Face of Liver Transplantation in the United States: The Effect of HCV Antiviral Eras on Transplantation Trends and Outcomes.

Transplant Direct 2019 Mar 20;5(3):e427. Epub 2019 Feb 20.

Division of Hepatobiliary Surgery and Liver Transplantation, Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN.

Background: Hepatitis C virus (HCV) cirrhosis is the leading indication for liver transplantation in the United States, although nonalcoholic steatohepatitis (NASH) is on the rise. Increasingly effective HCV antivirals are available, but their association with diagnosis-specific liver transplantation rates and early graft survival is not known.

Methods: The Scientific Registry of Transplant Recipients database records were retrospectively stratified by HCV antiviral era: interferon (2003-2010), protease inhibitors (2011-2013), and direct-acting antivirals (2014 to present). Read More

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http://dx.doi.org/10.1097/TXD.0000000000000866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411219PMC
March 2019
1 Read

Phaeohyphomycosis caused by Medicopsis romeroi in solid organ transplant recipients: Report of two cases and comprehensive review of the literature.

Transpl Infect Dis 2019 Mar 13:e13072. Epub 2019 Mar 13.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Medicopsis romeroi is a melanized coelomycetous fungus, mainly found in tropical and subtropical regions and an uncommon cause of infection in solid organ transplant (SOT) recipients. We describe two cases of SOT recipients diagnosed with phaeohyphomycosis due to M romeroi and provide a comprehensive literature review. These infections should be considered in patients native to tropical countries with a localized skin and soft tissue infection. Read More

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http://dx.doi.org/10.1111/tid.13072DOI Listing
March 2019
1 Read

Center-level trends in utilization of HCV-exposed donors for HCV-uninfected kidney and liver transplant recipients in the United States.

Am J Transplant 2019 Mar 12. Epub 2019 Mar 12.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Several single-center reports of using HCV-viremic organs for HCV-uninfected (HCV-) recipients were recently published. We sought to characterize national utilization of HCV-exposed donors for HCV- recipients (HCV D+/R-) in kidney transplantation (KT) and liver transplantation (LT). Using SRTR data (April 1, 2015-December 2, 2018) and Gini coefficients, we studied center-level clustering of 1193 HCV D+/R- KTs and LTs. Read More

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http://dx.doi.org/10.1111/ajt.15355DOI Listing

Deep vein thrombosis during long-term surveillance of patients with liver transplantation.

Authors:
Alice Balaceanu

Ir J Med Sci 2019 Mar 8. Epub 2019 Mar 8.

Internal Medicine Department, "Sf. Ioan" Clinical Emergency Hospital, "Carol Davila" University of Medicine and Pharmacy, Sos. Vitan-Bârzești nr. 13, Bucharest, Romania.

Background: In the European Liver Transplant Registry, there are 137,863 liver transplantations recorded. Forty-one percent of patients survived 20 years after liver transplantation in the European countries. From 1988, when the US database for liver transplantation was created, to 2006, there are more than 56,000 liver transplants. Read More

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http://dx.doi.org/10.1007/s11845-019-01998-6DOI Listing

Split versus living-related adult liver transplantation: a systematic review and meta-analysis.

Langenbecks Arch Surg 2019 Mar 7. Epub 2019 Mar 7.

Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Queen Elizabeth University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham, B15 2TH, UK.

Background-objective: The outcomes of split liver transplantation between recipients of deceased donor split liver transplant (SLT) or live donor liver transplants (LDLT) have never been compared in meta-analysis. It is important to understand graft and recipient survival between recipients of these grafts.

Methods: Databases were searched for relevant articles over the previous 20 years (MEDLINE, Embase, Cochrane Library and Google Scholar). Read More

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http://dx.doi.org/10.1007/s00423-019-01771-4DOI Listing
March 2019
2.160 Impact Factor

United Network for Organ Sharing Rule Changes and Their Effects on Kidney and Liver Transplant Outcomes.

Exp Clin Transplant 2019 Mar 5. Epub 2019 Mar 5.

From the University of Toledo Medical Center, Toledo, Ohio, USA.

Objectives: Recent national organ distribution rule changes could have implications on distance between donor and recipient hospitals and cold ischemia time. With cold ischemia time being an unavoidable detriment to organ quality, any strategies that minimize it should maximize organ quality. This study evaluated the significance of the kidney allocation system and the Share 35 rule changes on kidney and liver transplant outcomes. Read More

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http://dx.doi.org/10.6002/ect.2018.0311DOI Listing
March 2019
1 Read

Thanatometabolomics: introducing NMR-based metabolomics to identify metabolic biomarkers of the time of death.

Metabolomics 2019 Mar 5;15(3):37. Epub 2019 Mar 5.

Department of Food and Nutritional Sciences, The University of Reading, Whiteknights Campus, Reading, RG6 6AP, UK.

Introduction: Death is the permanent cessation of the critical functions of the organism as a whole. However, the shutdown of a complex biological organism does not abruptly terminate at time of death. New high-throughput technologies allow the systematic investigation of the biochemical modulations occurring after death. Read More

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http://dx.doi.org/10.1007/s11306-019-1498-1DOI Listing
March 2019
2 Reads

Outcomes From Brain Death Donors With Previous Cardiac Arrest Accepted for Pancreas Transplantation: A Single-center Retrospective Analysis.

Ann Surg 2019 Feb 8. Epub 2019 Feb 8.

Renal Transplant Unit, Nephrology and Kidney Transplant Department, Hospital Clinic, Barcelona, Spain.

Objective: The aim of the study was to evaluate the effect of cardiac arrest time (CAT) in donors after brain death (DBD) donors on pancreas transplant outcome.

Summary Of Background Data: Results from donors after circulatory death report good outcomes despite warm ischemia times up to 57 minutes. Previous cardiac arrest in DBD has been addressed as a potential risk factor, but duration of the CAT has never been evaluated. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003218DOI Listing
February 2019
9 Reads

Transplant and risk of Parkinson disease.

Parkinsonism Relat Disord 2019 Feb 14. Epub 2019 Feb 14.

Washington University School of Medicine, Department of Neurology, 660 S. Euclid Ave, Campus Box 8111, St. Louis, 63110, MO, USA; University of the Witwatersrand, School of Public Health, Faculty of Health Sciences, 27 Saint Andrews Road, Johannesburg, South Africa. Electronic address:

Introduction: The pathophysiology of Parkinson's disease (PD) remains unclear, but growing evidence supports a role of neuroinflammation. The purpose of this study was to investigate the association between tissue transplantation and PD risk, given the importance of immunosuppressants in post-transplant management.

Methods: We performed a case-control study among Medicare beneficiaries age 66-90 using claims from 2004 to 2009. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.013DOI Listing
February 2019
6 Reads

Association between CXCL9/10 polymorphisms and acute rejection of liver allograft.

Medicine (Baltimore) 2019 Feb;98(8):e14612

Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia.

While increased serum concentrations of CXCL9/10 are associated with acute cellular rejection (ACR) occurrence, the association between CXCL9/10 single nucleotide polymorphisms (SNPs) and ACR after liver transplantation (LT) remains unknown.In the present case-control study, polymorphisms of CXCL9 (rs10336) and CXCL10 (rs3921) were determined by polymerase chain reaction in 215 liver transplant recipients. ACR was defined as biopsy proven within 6 months after LT. Read More

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http://dx.doi.org/10.1097/MD.0000000000014612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408087PMC
February 2019

OPTN/SRTR 2017 Annual Data Report: Liver.

Am J Transplant 2019 Feb;19 Suppl 2:184-283

Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN.

Data on adult liver transplants performed in the US in 2017 are notable for (1) continued growth in numbers of new waitlist registrants (11,514) and of transplants performed (8,082); (2) continued increase in the transplant rate (51.5 per 100 waitlist-years); (3) a precipitous decrease in waitlist registrations and transplants for hepatitis C-related indications; (4) reciprocal increases in waitlist registrants and recipients with alcoholic liver disease and with clinical profiles consistent with non-alcoholic fatty liver disease; and (5) continued improvement in graft survival despite changing recipient characteristics such as older age and higher rates of obesity. Variability in transplant rates remained by candidate race, presence of hepatocellular carcinoma, urgency status (status 1A versus model for end-stage liver disease (MELD) score >35), and geography. Read More

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http://doi.wiley.com/10.1111/ajt.15276
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http://dx.doi.org/10.1111/ajt.15276DOI Listing
February 2019
11 Reads

OPTN/SRTR 2017 Annual Data Report: Intestine.

Am J Transplant 2019 Feb;19 Suppl 2:284-322

Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN.

Despite improvements in medical and surgical treatment of intestinal failure, intestine transplant continues to play an important role. In 2017, 109 intestine transplants were performed, 62 in adults and 47 in children, reflecting the changed age distribution over the past decade of candidates waitlisted for intestine and intestine-liver transplant from largely pediatric to increasing proportions of adults. In 2017, 56. Read More

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http://dx.doi.org/10.1111/ajt.15277DOI Listing
February 2019

ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.

Med Sci Monit 2019 Feb 24;25:1469-1479. Epub 2019 Feb 24.

Department of General Surgery, Shengzhou People's Hospital, Branch of First Affiliated Hospital of Zhejiang University, Shengzhou, Zhejiang, China (mainland).

BACKGROUND Intrahepatic and distant metastases could be the major cause of treatment failure in hepatocellular carcinoma (HCC). The deep mechanism of HCC metastasis is closely related to the interaction between integrins and extracellular matrix (ECM) in tumor microenvironment. MATERIAL AND METHODS In vitro cell adhesion assay was performed to determine the capability of adhering to ECM elements of HCC cells. Read More

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http://dx.doi.org/10.12659/MSM.911944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398282PMC
February 2019
2 Reads

Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases.

Pediatr Transplant 2019 Feb 21:e13379. Epub 2019 Feb 21.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Database linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart-lung, and small bowel transplants. Read More

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http://dx.doi.org/10.1111/petr.13379DOI Listing
February 2019

Cystic fibrosis and portal hypertension: Distal splenorenal shunt can prevent the need for future liver transplant.

J Pediatr Surg 2019 Feb 2. Epub 2019 Feb 2.

Division of Transplant Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Background: The management of portal hypertension (PHT) in children with well compensated cirrhosis and cystic fibrosis (CF) is controversial. We present our experience with distal splenorenal shunting (DSRS) for the treatment of PHT as an alternative to liver transplantation (LT).

Methods: Between 2008 and 2017, 5 CF children underwent a DSRS at a pediatric hepatobiliary and transplantation referral center. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.035DOI Listing
February 2019
2 Reads

Is liver transplantation 'out-of-hours' non-inferior to 'in-hours' transplantation? A retrospective analysis of the UK Transplant Registry.

BMJ Open 2019 Feb 20;9(2):e024917. Epub 2019 Feb 20.

Sheila Sherlock Liver Centre, Royal Free Hospital and the UCL Institute for Liver and Digestive Health, London, UK.

Objectives: Increased morbidity and mortality have been associated with weekend and night-time clinical activity. We sought to compare the outcomes of liver transplantation (LT) between weekdays and weekends or night-time and day-time to determine if 'out-of-hours' LT has acceptable results compared with 'in-hours'.

Design, Setting And Participants: We conducted a retrospective analysis of patient outcomes for all 8816 adult, liver-only transplants (2000-2014) from the UK Transplant Registry. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398642PMC
February 2019

Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient.

Pediatr Transplant 2019 Feb 18:e13370. Epub 2019 Feb 18.

Section of Hematology, Oncology and BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Read More

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http://dx.doi.org/10.1111/petr.13370DOI Listing
February 2019
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Emergency Department Visits After Kidney, Liver, and Heart Transplantation in a Hospital of a University in Turkey: A Retrospective Study.

Exp Clin Transplant 2019 01;17(Suppl 1):264-269

From the Department of Public Health, Baskent University, Ankara, Turkey.

Objectives: In our country, there are few publications evaluating emergency department visits among kidney, liver, and heart transplant recipients. Here, we examined emergency department visits of transplant recipients after initial hospital discharge following organ transplant performed in a medical faculty hospital in Ankara, Turkey.

Materials And Methods: We retrospectively analyzed hospital records of 1144 transplant recipients (700 kidney, 332 liver, and 112 heart) who underwent living-donor and deceased-donor organ transplant procedures in a university hospital between 2007 and 2017 and were admitted to the emergency department during the same period. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P120DOI Listing
January 2019
2 Reads

Liver Donation From Marginal Donors: To Donate or Not to Donate?

Exp Clin Transplant 2019 01;17(Suppl 1):254-256

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Livers from deceased donors compose nearly 30% of all organ transplants, and about 700 liver transplants are carried out per year. Marginal livers (extended-criteria donors), however, are not usually accepted by recipient teams, and there is only one center for these procedures in Iran. The final decision is made according to criteria that are much more conservative than other globally accepted ones. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P112DOI Listing
January 2019
3 Reads

Demographic Differences Between Two 7-Year Periods of Organ Donation in Iran: A Single-Center Experience.

Exp Clin Transplant 2019 01;17(Suppl 1):242-245

From the Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Donor characteristics can directly affect transplant outcomes. In this study, we examined donor patterns in an organ procurement unit, which covered one-third of the population in Tehran, Iran over the past 12 years (2005 to 2018).

Materials And Methods: Demographic data of donors, including sex, age, cause of death, blood group, outcome of donation, number of organs per donor, and comorbidities (including diabetes mellitus and hypertension), were assessed. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P106DOI Listing
January 2019
4 Reads

Gender Imbalance and the Relationship Between Living Donors and Recipients in Liver Transplantations in an Organ Transplant Center in Turkey.

Exp Clin Transplant 2019 01;17(Suppl 1):131-134

From the Department of Public Health, Baskent University, Ankara, Turkey.

Objectives: Because of the scarcity of publications on gender differences and the relationship between living donors and recipients in liver transplant procedures, we carried out this study with the objective to examine the gender distribution of donors and recipients and the relationships between donors and recipients in living related-donor liver transplants performed in a university hospital in Ankara, Turkey.

Materials And Methods: We retrospectively evaluated the data of 549 patients who underwent living related-donor and deceased-donor liver transplant procedures conducted in a university hospital between 1988 and 2017 and the 409 living donors.

Results: Males constituted 53. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O82DOI Listing
January 2019
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Update on Chronic Rejection After Intestinal Transplant: An Overview From Experimental Settings to Clinical Outcomes.

Exp Clin Transplant 2019 01;17(Suppl 1):18-30

From the St. Orsola University Hospital Alma Mater Studiorum, Bologna, Italy.

Chronic rejection affects the long-term survival of solid-organ transplants, accounting for an incidence of between 5% and 10% after intestinal/multivisceral transplant. Because of unclear symptoms and signs and endoscopic findings, the diagnosis is often delayed. Presently, allograft removal represents the only available therapy due to the absence of effective pharmacologic approaches. Read More

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http://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=10.60
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http://dx.doi.org/10.6002/ect.MESOT2018.L32DOI Listing
January 2019
6 Reads

Implementation of a Strongyloides screening strategy in solid organ transplant donors and recipients.

Clin Transplant 2019 Apr 12;33(4):e13497. Epub 2019 Mar 12.

Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.

Background: Strongyloides stercoralis infects 100 million people worldwide. Mortality rates in hyperinfection syndrome exceed 50%. Donor-derived Strongyloides infection has occurred after heart, kidney, kidney-pancreas and liver transplantation; yet, only 10% of the US organ procurement organizations currently screen donors for strongyloidiasis. Read More

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http://dx.doi.org/10.1111/ctr.13497DOI Listing
April 2019
3 Reads

Safety and Efficacy of Transjugular Liver Biopsy in Patients with Left Lobe-Only Liver Transplants.

J Vasc Interv Radiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-361, San Francisco, CA 94143.

Purpose: To evaluate efficacy and safety of transjugular liver biopsy (TJLB) via the left hepatic vein in patients with left lobe-only liver transplants (LLOTs).

Materials And Methods: Retrospective review revealed 43 TJLBs performed in 26 patients with LLOTs (mean age 51.3 y; range, 18-73 y) between January 2009 and June 2016 at a single institution. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.07.026DOI Listing
February 2019
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Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.

Eur J Med Chem 2019 Apr 7;167:187-199. Epub 2019 Feb 7.

School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China. Electronic address:

To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2), and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect. Combining the data of cytotoxicity, cytocompatibility and anti-inflammatory activity, 3-pyridyl and -CF substituted 67 may be the potential anti-hepatoma agent. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.020DOI Listing
April 2019
5 Reads

Current status of graft-versus-host disease after intestinal transplantation.

Curr Opin Organ Transplant 2019 Apr;24(2):199-206

Division of Pediatric Transplantation, Department of Surgery, Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Thomas E. Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Purpose Of Review: Over the past decades, visceral transplantation has become the standard of care for patients with irreversible intestinal failure who suffer complications of total parenteral nutrition (TPN). Graft-versus-host disease (GVHD) after solid organ transplantation is a rare but often fatal complication with high mortality. GVHD after intestinal transplantation, given the large lymphoid content of the graft, is more frequent compared with other solid organs. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000624DOI Listing
April 2019
14 Reads

Assessment of Trends in Transplantation of Liver Grafts From Older Donors and Outcomes in Recipients of Liver Grafts From Older Donors, 2003-2016.

JAMA Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: In light of the growing population of older adults in the United States, older donors (aged ≥70 years) represent an expansion of the donor pool; however, their organs are underused. Liver grafts from older donors were historically associated with poor outcomes and higher discard rates, but clinical protocols, organ allocation, and the donor pool have changed in the past 15 years.

Objective: To evaluate trends in demographics, discard rates, and outcomes among older liver donors and transplant recipients of livers from older donors in a large national cohort. Read More

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http://dx.doi.org/10.1001/jamasurg.2018.5568DOI Listing
February 2019
2 Reads

A Case of Donor-Transmitted Non-Small Cell Lung Cancer After Liver Transplantation: An Unwelcome Guest.

Oncologist 2019 Feb 12. Epub 2019 Feb 12.

Mayo Clinic Cancer Center, Phoenix, Arizona, USA

Cancer transmission with organ donation has been previously reported with a variety of malignancies and organ transplants. The risk of transmission through organ transplantation from donors with a history of previously treated malignancies has been addressed by guidelines from transplant societies. Herein, we report a case of a patient who developed lung cancer confined to the liver after liver transplantation with no known history of malignancy in the donor. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0517DOI Listing
February 2019
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Influence of the procurement surgeon on transplanted abdominal organ outcomes: An SRTR analysis to evaluate regional organ procurement collaboration.

Am J Transplant 2019 Feb 12. Epub 2019 Feb 12.

Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.

Single-center studies have demonstrated regional organ procurement collaboration to reduce travel redundancy and improve procurement efficiency. We studied deceased donor kidney, liver, and pancreas transplants performed in the United States between 2002 and 2014 using the Scientific Registry of Transplant Recipients (SRTR). We compared graft failure (GF), death-censored graft failure (DCGF), and patient death (PD) between organs procured by surgeons from the recipient's center (transplant procurement team [TPT]) versus surgeons from a different center (NTPT). Read More

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http://dx.doi.org/10.1111/ajt.15301DOI Listing
February 2019
4 Reads