8,362 results match your criteria Transplants Liver


Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore.

Transplant Direct 2020 Jun 8;6(6):e554. Epub 2020 May 8.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Read More

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http://dx.doi.org/10.1097/TXD.0000000000001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363PMC

The impact of switching to mTOR inhibitor-based immunosuppression on long-term non-melanoma skin cancer incidence and renal function in kidney and liver transplant recipients.

Ren Fail 2020 Nov;42(1):607-612

Department of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Solid organ transplantation is associated with increased risk of non-melanoma skin cancer. Studies with short follow up times have suggested a reduced occurrence of these cancers in recipients treated with mammalian target of rapamycin inhibitors as maintenance immunosuppression. We aimed to describe the occurrence of skin cancers in renal and liver transplant recipients switched from calcineurin inhibitor to sirolimus-based regimes. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1785499DOI Listing
November 2020

Clinical Impact of Antecedent Bariatric Surgery on Liver Transplant Outcomes: A Retrospective Matched Case-control Study.

Transplantation 2020 Jun 23. Epub 2020 Jun 23.

Division of Transplantation, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, U.S.A.

Background: Bariatric surgery (BS) may be associated with significant malabsorption and nutritional deficiencies.

Methods: Between March 1987 and January 2017, we performed 922 liver transplants (LT) at our institution; 33 had antecedent BS. We matched the BS cohort to LT recipients without BS (1:3 matching) based on exact matching for gender and cancer and inverse variance matching for age, LT BMI, MELD score, and transplant date. Read More

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http://dx.doi.org/10.1097/TP.0000000000003378DOI Listing

Challenges for Liver Transplantation During Recovery From the COVID-19 Pandemic: Insights and Recommendations.

Transplant Proc 2020 Jun 4. Epub 2020 Jun 4.

Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.

The coronavirus disease 2019 (COVID-19) pandemic is placing an increasing burden on liver transplant (LT) services worldwide. At the peak of the pandemic, many LT services worldwide reduced or halted their activities. With the gradual easing of lockdowns, LT teams face new challenges when restarting activities. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269961PMC

Immunosuppression in Donation after Circulatory Determination of Death Liver Transplantation: Can Induction Modify Graft Survival?

Liver Transpl 2020 Jun 24. Epub 2020 Jun 24.

Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States.

Background: Recipients of donation after circulatory determination of death (DCDD) liver transplants historically have an increased risk of graft failure. Antibody induction (AI) with anti-thymocyte globulin (ATG) or anti-IL2 receptor (anti-IL-2R) immunotherapy may decrease the incidence of graft failure by mitigating ischemia reperfusion injury.

Methods: A retrospective review of the UNOS database for liver transplants between 2002 and 2015 was conducted to determine whether ATG or anti-IL-2R AI was associated with graft survival in DCDD. Read More

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http://dx.doi.org/10.1002/lt.25762DOI Listing

Transforming the spleen into a liver-like organ in vivo.

Sci Adv 2020 Jun 10;6(24):eaaz9974. Epub 2020 Jun 10.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210093, China.

Regenerating human organs remains an unmet medical challenge. Suitable transplants are scarce, while engineered tissues have a long way to go toward clinical use. Here, we demonstrate a different strategy that successfully transformed an existing, functionally dispensable organ to regenerate another functionally vital one in the body. Read More

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http://dx.doi.org/10.1126/sciadv.aaz9974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286668PMC

Analysis of Organ Utilization From Deceased Organ Donation in India.

Transplant Proc 2020 Jun 20. Epub 2020 Jun 20.

Department of Renal Transplant Surgery, Nehru Building, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Objectives: This report presents an audit of utilization of various organs from deceased donors in different states of India over a 3-year period METHODS: Data released by the various regions on their official website was analyzed from 2015 to 2017.Regions with less than 25 donations per year were excluded while calculating utilization rates.

Results: Total organ donation in India had increased from 570 to 843 donations from 2015 to 2017 (47. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.134DOI Listing

Effect of COVID-19 on liver transplantation in KOREA.

Authors:
Jeong-Moo Lee

Transpl Infect Dis 2020 Jun 23:e13384. Epub 2020 Jun 23.

Department of Surgery, Seoul National University Hospital, Seoul, Korea.

COVID-19 is now a pandemic with increasing numbers of cases and deaths. In addition to the economic and social damage caused by COVID-19 outbreak prolongation, damage caused by delayed treatment of other diseases such as severe cirrhosis is also serious. We aimed to describe the effect of COVID-19 on the number of liver transplants (LT) in South Korea. Read More

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http://dx.doi.org/10.1111/tid.13384DOI Listing

Simultaneous Heart-Liver Transplantation for Congenital Heart Disease in the USA: Rapidly Increasing with Acceptable Outcomes.

Hepatology 2020 Jun 19. Epub 2020 Jun 19.

Center for Liver Diseases, The University of Chicago Medicine, Chicago, IL, USA.

Background: There are more adults than children living with congenital heart disease (CHD) in the US, with a growing proportion requiring heart-liver transplantation (HLT). Our aim was to ascertain the frequency, outcomes and prognostic factors in this patient population.

Methods: UNOS data on adult patients who underwent heart transplantation (HT) from 2009 through March 2020 were analyzed. Read More

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http://dx.doi.org/10.1002/hep.31426DOI Listing

Reply to "Living liver donation in previous kidney donors: A single-center experience".

Am J Transplant 2020 Jun 18. Epub 2020 Jun 18.

Division of Transplant Surgery, Department of Surgery, University of Colorado, Aurora, Colorado, USA.

We want to thank Nair et al.[1] for their experience highlighting the feasibility and safety of living liver donation after prior kidney donation. As the authors point out, while living donor liver transplantation remains a small percentage of total transplants in the United States, multiorgan donation is becoming more common [2]. Read More

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http://dx.doi.org/10.1111/ajt.16153DOI Listing

Fungal endocarditis in transplant recipients: a systematic review.

Mycoses 2020 Jun 18. Epub 2020 Jun 18.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Invasive fungal infections remain a major cause of morbidity and mortality in transplant recipients. Moreover, Fungal Infective Endocarditis (FIE) is a rare infection that carries a higher mortality than bacterial IE in normal host, while in transplant recipients may be even higher. The purpose of this study was to systemically review all published cases of FIE in solid organ and allogeneic bone marrow transplant recipients, describe the epidemiology, microbiology, clinical characteristics, treatment and outcomes of these infections, and to identify risk factors for mortality by FIE. Read More

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http://dx.doi.org/10.1111/myc.13132DOI Listing

Rescue Hepatectomy and Anhepatic Phase Management After Primary Nonfunction in a Liver Transplant.

Exp Clin Transplant 2020 Jun 16. Epub 2020 Jun 16.

>From the Division of Transplantation, Department of Surgery, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

Primary nonfunction is a rare but lethal complication that occurs in a small number of liver transplants. When primary nonfunction occurs, the only definite treatment is retransplant; however, another liver might not be readily available at that time. Hence, a surgeon should be aware of the various options available at hand for patient care during the time interval between the primary nonfunction and retransplant. Read More

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http://dx.doi.org/10.6002/ect.2020.0129DOI Listing

Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing).

Am J Cardiol 2020 05 24. Epub 2020 May 24.

Division of Cardiovascular Diseases, Section of Heart Failure and Transplant, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Studies have shown that highly selected patients who underwent combined heart-kidney (HK) and heart-liver transplants (HLv) have short- and long-term outcomes comparable to those observed in primary heart transplantation (HT). Adults patients with stage D heart failure that underwent combined HK, HLv, and heart-lung (HL) were identified in the United Network for Organ Sharing registry from 1991 to 2016, with follow-up through March 2018. We conducted inverse probability of treatment weighting survival analysis of long-term survival stratified by type of combined organ transplant, accounting for donor, recipient, and operative characteristics. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.05.034DOI Listing

Deceased donation and organ transplantation in Mexico. Analysis of 12 years and seven strategic proposals.

Cir Cir 2020 ;88(3):254-262

Servicio Hospitalario de la Donación, Unidades Médicas de Alta Especialidad, Hospital de Especialidades N.º 1, Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, León, Guanajuato. México.

Background: The evolution of the activity of deceased organ donation and solid organ transplantation in Mexico was analyzed for the period of 2004-2018.

Method: The information of deceased donation and organ transplantation in Mexico was collected and ordered for said period. When there was no complete information for 2018, the data for 2017 were used instead. Read More

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http://dx.doi.org/10.24875/CIRU.19001379DOI Listing
January 2020

Modelling the Economic and Clinical Burden of Non-Alcoholic Steatohepatitis in East Asia: Data from Hong Kong.

Hepatol Res 2020 Jun 14. Epub 2020 Jun 14.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States.

Background: Non-alcoholic steatohepatitis (NASH) is the progressive form of non-alcoholic fatty liver disease (NAFLD) and prevalence is rising in Asia due to increases rates of urbanization, sedentary lifestyles, and poor nutrition.

Methods: We built a Markov model with 20-year horizon to estimate the burden of NASH in Hong Kong. Cohort size was determined by population size, prevalence of NAFLD, and incidence of NASH in 2017. Read More

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http://dx.doi.org/10.1111/hepr.13535DOI Listing

Clinical pharmacy programmatic perspectives on use of direct-acting antivirals for acquired hepatitis C infection in solid organ transplant recipients.

Am J Health Syst Pharm 2020 Jun 15. Epub 2020 Jun 15.

University of North Carolina Hospitals, Chapel Hill, NC.

Purpose: An institutional workflow developed by clinical pharmacists for initiation of directing-acting antiviral (DAA) therapy for patients who receive solid organ transplants from hepatitis C (HCV)-positive donors is described; programmatic challenges in providing pharmaceutical care to these patients are reviewed.

Summary: In recent years the introduction of new oral DAAs, coupled with faster screening of donor organs for HCV infection through use of a nucleic acid test (NAT), has facilitated transplants of organs from HCV-seropositive donors to HCV-seronegative recipients. The solid organ transplant program of a North Carolina health system began performing such transplants in December 2017. Read More

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http://dx.doi.org/10.1093/ajhp/zxaa150DOI Listing

Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence.

World J Gastroenterol 2020 May;26(17):1987-1992

Departments of Surgery, Mayo Clinic, Rochester, MN 55905, United States.

This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis, and recent evidence suggests that chronic inflammation precedes fibrosis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i17.1987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267692PMC
May 2020
2.369 Impact Factor

Current status of liver transplantation in Asia.

Int J Surg 2020 Jun 11. Epub 2020 Jun 11.

Institute of Liver Transplantation and Regenerative Medicine, Medanta-The Medicity, Delhi-NCR, India. Electronic address:

In spite of early adoption of the brain death legislation, and all efforts at promoting deceased donation, various social, economic and cultural factors have acted as road blocks to the furthering of deceased donor liver transplantation (DDLT) in most Asian societies. On the other hand, Asian liver transplant centers have been the pioneers, innovators, and technical advancement catalysts for the world to follow, especially with regards to living donor liver transplantation (LDLT). With some high volume centers performing more than 200 LDLTs a year with good outcomes in the donor and recipient, techniques to expand the living donor pool have also been adopted like ABO-incompatible, paired exchange and dual lobe living donor liver transplants. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.05.071DOI Listing

Liver Transplantation from Controlled donors after Circulatory Death using Normothermic Regional Perfusion: Initial Experience of the French Procotol.

Liver Transpl 2020 Jun 12. Epub 2020 Jun 12.

Service de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, CHU Pitié-Salpetriere, Sorbonne Université, Paris, France.

A national program of controlled donation after circulatory death (cDCD) began in France in 2014 involving the use of a standardized national protocol, which involves systematic use of normothermic regional perfusion (NRP). In this article, we describe in detail the French cDCD program. Between January 1 , 2015, and December 31 , 2018, 225 livers were offered for donation, resulting in 123 cDCD liver transplants (LTs). Read More

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http://dx.doi.org/10.1002/lt.25818DOI Listing

Candida auris outbreak involving liver transplant recipients in a Surgical Intensive Care Unit.

Am J Transplant 2020 Jun 12. Epub 2020 Jun 12.

University of Massachusetts, Medical School Division of Infectious Disease, Worcester, MA, USA.

Candida auris is a difficult to eradicate yeast that has caused outbreaks in healthcare facilities. We report a cluster of five patients in one intensive care unit who were colonized or infected in 2017. The initial two patients were recipients of liver transplants who had cultures that grew C. Read More

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http://dx.doi.org/10.1111/ajt.16144DOI Listing

The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis.

Semin Liver Dis 2020 Jun 11. Epub 2020 Jun 11.

Department of Pediatric Gastroenterology, University of California, San Diego (UCSD), San Diego, California and Rady Children's Hospital, San Diego, California.

Nonalcoholic steatohepatitis (NASH) and alcoholic hepatitis (ASH) are advanced forms of fatty liver diseases that are associated with a high morbidity and mortality worldwide. Patients with ASH or NASH are more susceptible to the progression of fibrosis and cirrhosis up to the development of hepatocellular carcinoma. Currently, there are limited medical therapies available. Read More

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http://dx.doi.org/10.1055/s-0040-1708540DOI Listing

Living Donor Liver Paired Exchange: A North American First.

Am J Transplant 2020 Jun 10. Epub 2020 Jun 10.

Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, Canada.

Paired organ exchange can be used to circumvent living donor-recipient ABO incompatibilities. Herein, we present the first case of successful liver paired exchange in North America. This two-way swap required four simultaneous operations: two living donor hepatectomies and two living donor liver transplants. Read More

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http://dx.doi.org/10.1111/ajt.16137DOI Listing

Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants.

Sci Rep 2020 Jun 9;10(1):9292. Epub 2020 Jun 9.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, 19104, USA.

Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance immunosuppression was not essential for graft acceptance. We tested whether peri-transplant costimulation blockade could prolong VCA survival and required donor bone-marrow cells, given that bone-marrow might promote graft immunogenicity or graft-versus-host disease. Peritransplant CD154 mAb/rapamycin (RPM) induced long-term orthotopic hindlimb VCA survival (BALB/c->C57BL/6), as did CTLA4Ig/RPM. Read More

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http://dx.doi.org/10.1038/s41598-020-66139-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283338PMC

Early and Recurrent Hospitalization after Kidney Transplantation: Analysis of a Contemporary Canadian Cohort of Kidney Transplant Recipients.

Clin Transplant 2020 Jun 9:e14007. Epub 2020 Jun 9.

Division of Nephrology, Department of Medicine, Dalhousie University, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

Hospital readmission is a common occurrence following kidney transplantation, but less is known about the predictors of early and recurrent hospitalization. We analyzed a cohort of adult kidney transplant recipients in Nova Scotia, Canada from Jan 2010 to Dec 2015. Readmission rates for 30 days, 6 months, and 1-year were calculated as a proportion of total transplants. Read More

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http://dx.doi.org/10.1111/ctr.14007DOI Listing

Glutathione S-transferase T1 mismatch is a risk factor for chronic ductopenic rejection of liver allografts.

Liver Transpl 2020 Jun 8. Epub 2020 Jun 8.

Immunology Laboratory, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, 41013, Sevilla, Spain.

The underlying causes of chronic rejection (CR) after liver transplantation are not completely known. The main aim of this study was to explore the involvement of the minor histocompatibility antigen glutathione S-transferase T1 (GSTT1) in CR. We retrospectively studied 611 patients who underwent liver transplants at University Hospital Virgen del Rocío between 2003 and 2016 with a median follow-up of 7. Read More

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http://dx.doi.org/10.1002/lt.25815DOI Listing

A Direct Comparison Between Institut Georges Lopez 1 and Histidine-Tryptophan-Ketoglutarate Preservation Solutions in Liver Transplantation.

Transplant Proc 2020 Jun 3;52(5):1262-1264. Epub 2020 Jun 3.

Albert Einstein Israelite Hospital, São Paulo, Brazil.

Background: The Institut Georges Lopez 1 (IGL-1) solution was developed to improve the outcomes of solid organ transplantation. Nevertheless, follow-up of liver transplants using IGL-1-preserved organs is still scarce.

Aim: To compare morbidity, postoperative complications, and early survival between liver grafts perfused with IGL-1 and those perfused with histidine-tryptophan-ketoglutarate (HTK) solutions. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.172DOI Listing

São Paulo State Liver Transplantation Supply Chain Study.

Transplant Proc 2020 Jun 2;52(5):1247-1250. Epub 2020 Jun 2.

Medical School, Federal University of São Paulo, São Paulo, São Paulo, Brazil; Euryclides de Jesus Zerbini Transplantation Hospital, São Paulo, Brazil. Electronic address:

Background: The number of liver transplantations is increasing worldwide, and Brazil ranks in the second position. It has one of the biggest public health care systems, which is responsible for the coordination and financial funding of transplantation procedures. Meeting the demands of such a large system of transplantation has become a challenge, particularly when attempting to minimize costs of scarce and expensive resources. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.181DOI Listing

Textbook Outcomes in Liver Transplantation.

World J Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, Duke University Medical Center, Box 3512, Durham, NC, 27710, USA.

Background: Textbook outcome (TO) is an emerging concept within multiple surgical domains, which represents a novel effort to define a standardized, composite quality benchmark based on multiple postoperative endpoints that represent the ideal "textbook" hospitalization. We sought to define TO for liver transplantation (LT) using a cohort from a high procedural volume center.

Methods: Patients who underwent LT at our institution between 2014 and 2017 were eligible for the study. Read More

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http://dx.doi.org/10.1007/s00268-020-05625-9DOI Listing

Kidney transplantation and other methods of renal replacement therapy in children: 30 years of observations in one center.

Adv Clin Exp Med 2020 May;29(5):611-613

Department of Pediatric Nephrology, Wroclaw Medical University, Poland.

Background: Kidney transplantation (Tx) is regarded as the optimal treatment method for renal replacement therapy (RRT) for end-stage renal disease (ESRD) patients. Children qualified for Tx should receive the organ as soon as possible in order to improve their chances for healthy development. In our center, RRT for children with ESRD has been conducted for 36 years: hemodialysis (HD) since 1982, peritoneal dialysis (PD) since 1992 and the first transplant in 1987. Read More

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http://dx.doi.org/10.17219/acem/121928DOI Listing

The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.

Transplantation 2020 May 25. Epub 2020 May 25.

Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States, 94143.

Background: Acute kidney injury (AKI) after liver transplantation is associated with increased morbidity and mortality. It remains controversial whether the choice of vena cava reconstruction technique impacts AKI.

Methods: This is a single-center retrospective cohort of 897 liver transplants performed between June 2009 and September 2018 using either the vena-cava preserving piggyback technique or caval replacement technique without veno-venous bypass or shunts. Read More

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http://dx.doi.org/10.1097/TP.0000000000003331DOI Listing

Regenerative medicine, organ bioengineering and transplantation.

Br J Surg 2020 Jun;107(7):793-800

Department of Surgery, Section of Transplantation, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.

Background: Organ transplantation is predicted to increase as life expectancy and the incidence of chronic diseases rises. Regenerative medicine-inspired technologies challenge the efficacy of the current allograft transplantation model.

Methods: A literature review was conducted using the PubMed interface of MEDLINE from the National Library of Medicine. Read More

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http://dx.doi.org/10.1002/bjs.11686DOI Listing

Results of Green Indocyanine in the Use of the R1T1 Robot as Aid in the Pre-operative Process of Hepatic Organ Transplant: Experiment in Wistar Rats.

Transplant Proc 2020 Jun 24;52(5):1397-1398. Epub 2020 May 24.

Department of Surgical Science, Campinas State University, Campinas, Brazil.

Since the beginning of the history of transplants, numerous difficulties have been faced in the effective implementation of this therapeutic practice, especially with regard to the transplantation of solid organs and their teaching and training, together with the time of removal and transplantation of the organ that directly influences the results of the transplant surgical procedure. The objective of this research was to demonstrate the results found on the process of using green indocyanine during the invention of the Automatic Portable Surgical Communication Equipment with the Robot R1T1 (APSCERR), as well as to demonstrate its capabilities in the medical area of organ transplantation. Biochemical exams, liver profile exams, and mitochondrial breathing exams were performed on the control group and on the indocyanine group. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.013DOI Listing

Effective dose for multiple and repeated radiation examinations in donors and recipients of adult-to-adult living donor liver transplants at a single center.

Eur J Radiol 2020 May 16;129:109078. Epub 2020 May 16.

Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung 402, Taiwan; Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, Taiwan. Electronic address:

Purpose: To evaluate the effective doses received by donors and recipients, identify effective dose contributions, and make risk assessments.

Materials And Methods: It was a retrospective study. 100 Donors and 100 recipients were enrolled with an operative day from March 2016 to August 2017. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109078DOI Listing

Effects of Primary Sclerosing Cholangitis on Risks of Cancer and Death in People With Inflammatory Bowel Diseases, Based on Sex, Race, and Age.

Gastroenterology 2020 May 20. Epub 2020 May 20.

NIHR Birmingham Biomedical Research Centre, Centre for Liver and Gastroenterology Research, University of Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, UK; Toronto Centre for Liver Disease, University Health Network and Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Background & Aims: There are insufficient population-level data on effects of primary sclerosing cholangitis (PSC) in patients with inflammatory bowel disease (IBD).

Methods: We identified incident cases of IBD, with PSC (PSC-IBD) and without, from April 2006 through to April 2016 and collected data on outcomes through April 2019. We linked data from national healthcare registries maintained for all adults in England on hospital attendances, imaging and endoscopic evaluations, surgical procedures, cancer, and deaths. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.05.049DOI Listing

Model for early allograft function is predictive of early graft loss in donation after circulatory death liver transplantation.

Clin Transplant 2020 May 22:e13982. Epub 2020 May 22.

University of Cambridge Department of Surgery, Addenbrooke's Hospital, Cambridge, UK.

Donation after circulatory death (DCD) liver transplantation is associated with higher rates of graft loss. In this paper, we explored whether the Model for Early Allograft Function (MEAF) predicted outcome in DCD liver transplantation. We performed a retrospective analysis of prospectively collected data from all adult DCD (Maastricht 3) livers transplanted in Cambridge and Edinburgh between 1 January 2011 and 30 June 2017, excluding those undergoing any form of machine perfusion. Read More

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http://dx.doi.org/10.1111/ctr.13982DOI Listing

Transplanting Livers From "HCV-Positive" Donors To HCV-Negative Recipients: Increased Experience But Many Unanswered Questions.

Am J Gastroenterol 2020 May 20. Epub 2020 May 20.

Division of Digestive Health and Liver Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.

Over the past several years, single- and multi-center case series have reported on the successful use of livers from hepatitis C virus (HCV)-antibody positive and HCV-viremic donors to HCV-negative recipients. Several authors have studied not only the efficacy of this practice but also its cost-effectiveness of transplanting HCV-infected organs to HCV-negative donors. However, previous studies had limited follow-up and had not examined transplants beyond the beginning of 2018. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000649DOI Listing

Does Routine Abdominal Drain Tip Culture Anticipate Post-Operative Infection in Liver Transplantation?

Surg Infect (Larchmt) 2020 May 20. Epub 2020 May 20.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Bacterial infections are a common complication after liver transplantation. Usually, abdominal drains are placed at the end of the surgical procedure. The usefulness of routine drain tip culture has not been investigated. Read More

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http://dx.doi.org/10.1089/sur.2020.031DOI Listing

Induction regimens and post-transplantation lymphoproliferative disorder after pediatric intestinal transplantation: Single-center experience.

Pediatr Transplant 2020 May 19:e13723. Epub 2020 May 19.

Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Pediatric recipients of intestinal transplants have a high incidence of PTLD, but the impact of specific induction immunosuppression agents is unclear. In this single-center retrospective review from 2000 to 2017, we describe the incidence, characteristics, and outcomes of PTLD after primary intestinal transplantation in 173 children with or without liver, after induction with rATG, alemtuzumab, or anti-IL-2R agents. Thirty cases of PTLD occurred among 28 children, 28 EBV+ and 2 EBV-. Read More

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http://dx.doi.org/10.1111/petr.13723DOI Listing

Diffuse primary cutaneous infection by in a liver transplant recipient with pulmonary nocardiosis: Importance of prompt identification for clinical resolution.

Med Mycol Case Rep 2020 Jun 4;28:42-45. Epub 2020 May 4.

Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

Fungal infections are rare in the general population but are an emerging cause of disease in immunosuppressed patients, especially solid organ transplant recipients. Here, we report the case of a female Caucasian liver transplant patient who developed pulmonary nocardiosis two months after an episode of liver rejection. At the time of lung nocardiosis, she was being treated with tacrolimus and corticosteroids and suffered from diffuse papular skin lesions. Read More

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http://dx.doi.org/10.1016/j.mmcr.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218148PMC

Decompensated cirrhosis is the commonest presentation for NAFLD patients undergoing liver transplant assessment.

Clin Med (Lond) 2020 May;20(3):313-318

UCL Institute for Liver and Digestive Health, London, UK

Non-alcoholic fatty liver disease (NAFLD) accounts for 10-15% of orthotopic liver transplants (OLTs) in the UK. Index presentations with cirrhotic decompensation represent missed opportunities for preventive treatment leaving OLT or palliation as the only options.We retrospectively reviewed patient records for all NAFLD patients undergoing assessment for OLT between January 2003 and December 2017. Read More

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http://dx.doi.org/10.7861/clinmed.2019-0250DOI Listing

Donor Age, Cold Ischemia Time, and Delayed Graft Function.

Clin J Am Soc Nephrol 2020 May 13. Epub 2020 May 13.

Abdominal Center, Department of Nephrology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background And Objectives: Increased donor age is one of the most important risk factors for delayed graft function (DGF), and previous studies suggest that the harmful effect of cold ischemia time is increased in kidneys from older donors. Our aim was to study the association of increased donor age and cold ischemia time with the risk of delayed graft function in a large cohort kidney transplants from the current era.

Design, Setting, Participants, & Measurements: The Scientific Registry of Transplant Recipients was used for this observational, retrospective registry analysis to identify all deceased donor kidney transplantations in the United States between 2010 and September 2018, who were on dialysis pretransplantation (=90,810). Read More

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http://dx.doi.org/10.2215/CJN.13711119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274280PMC

Livers From Pediatric Donation After Circulatory Death Donors Represent a Viable and Underutilized Source of Allograft.

Liver Transpl 2020 May 13. Epub 2020 May 13.

Division of Transplantation, University of Washington Medical Center, Seattle, WA.

Despite increased numbers of donation after circulatory death (DCD) donors, pediatric DCD livers are underused. To investigate possible reasons for this discrepancy, we conducted a retrospective cohort study using 2 data sets from the Organ Procurement and Transplantation Network for all deceased liver donors and for all recipients of DCD liver transplants from March 8, 1993, to June 30, 2018. Pediatric (0-12 years) and adolescent (13-17 years) DCD donors were compared with those aged 18-40 years. Read More

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http://dx.doi.org/10.1002/lt.25795DOI Listing

Observational Retrospective Study on Patient Lifestyle in the Pretransplantation and Post-transplantation Period in the Emilia-Romagna Region.

Transplant Proc 2020 Jun 10;52(5):1552-1555. Epub 2020 May 10.

Transplants Reference Center of the Emilia-Romagna region, Bologna, Italy.

Introduction: Despite the well-known benefits of exercise during the pretransplantation and post-transplantation phases, adherence to active lifestyles is still reduced. The aim of the present study is to evaluate how many patients who have received organ transplants and candidates for organ transplantation carry out physical or sports activities in order to increase adherence to an active lifestyle.

Methods: The patients who agreed to participate in the study were interviewed about their lifestyle habits by the staff at the nephrology, dialysis, and hepatology units of the Emilia-Romagna region. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.015DOI Listing

Changing indications for liver transplant: slow decline of hepatitis viruses in Italy.

Infect Dis (Lond) 2020 Aug 13;52(8):557-562. Epub 2020 May 13.

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.

The indications to LT are changing rapidly in Europe and the U.S. mainly due to the extensive use of direct-acting antiviral agents (DAA) against HCV. Read More

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http://dx.doi.org/10.1080/23744235.2020.1763453DOI Listing

Multiorgan procurement is associated with a survival benefit after heart transplantation.

Clin Transplant 2020 May 13:e13901. Epub 2020 May 13.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

We assessed the impact of donor multiorgan procurement on survival following orthotopic heart transplantation (OHT). From the UNOS STAR database, we included all adult (≥18 Y) heart transplants (OHT) performed since 2000 and used donor IDs to determine how many other organs were procured from the same donor as the recipient's heart allograft (regardless of recipient). The Kaplan-Meier survival functions and risk-adjusted Cox proportional hazards regression models were computed to assess the association of multiorgan procurement with post-heart transplantation mortality. Read More

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http://dx.doi.org/10.1111/ctr.13901DOI Listing

Use of SARS-CoV-2-infected deceased organ donors: Should we always "just say no?"

Am J Transplant 2020 Jul 11;20(7):1787-1794. Epub 2020 Jun 11.

Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.

In the context of a rapidly evolving pandemic, multiple organizations have released guidelines stating that all organs from potential deceased donors with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection should be deferred, including from otherwise medically eligible donors found to have mild or asymptomatic SARS-CoV-2 discovered on routine donor screening. In this article, we critically examine the available data on the risk of transmission of SARS-CoV-2 through organ transplantation. The isolation of SARS-CoV-2 from nonlung clinical specimens, the detection of SARS-CoV-2 in autopsy specimens, previous experience with the related coronaviruses SARS-CoV and MERS-CoV, and the vast experience with other common RNA respiratory viruses are all addressed. Read More

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http://dx.doi.org/10.1111/ajt.16000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272824PMC

Monitoring in Liver Transplantation Patients: A Single Center Cross-Sectional Study in an Italian Hospital.

Pathogens 2020 May 8;9(5). Epub 2020 May 8.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.

(TG) is one of the most widespread intracellular parasites in the world, despite the slight declining trend in industrialized countries. Whilst the infection is often asymptomatic in immunocompetent hosts, in immunocompromised patients such as organ transplant recipients it can have important clinical sequels with even fatal consequences. We retrospectively reviewed 568 primary liver transplants (LT) from deceased donors from 2012 to 2017. Read More

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http://dx.doi.org/10.3390/pathogens9050354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281584PMC

Short-course, direct-acting antivirals and ezetimibe to prevent HCV infection in recipients of organs from HCV-infected donors: a phase 3, single-centre, open-label study.

Lancet Gastroenterol Hepatol 2020 Jul 6;5(7):649-657. Epub 2020 May 6.

Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada; Soham and Shaila Ajmera Family Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.

Background: An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). After transplantation from an infected donor, establishment of HCV infection in uninfected recipients is near-universal, with the requirement for post-transplant antiviral treatment. The aim of this study was to determine if antiviral drugs combined with an HCV entry blocker given before and for 7 days after transplant would be safe and reduce the likelihood of HCV infection in recipients of organs from HCV-infected donors. Read More

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http://dx.doi.org/10.1016/S2468-1253(20)30081-9DOI Listing

Successful treatment of extreme drug resistant Acinetobacter baumannii infection following a liver transplant.

J Infect Dev Ctries 2020 Apr 30;14(4):408-410. Epub 2020 Apr 30.

Department of General Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey.

Orthotopic liver transplantation is a life-saving procedure for patients with end-stage liver failure. However, Acinetobacter baumannii infections and acute rejection are important causes of morbidity and mortality following transplants. Here we present a case report of a cadaveric donor liver transplantation with infectious complications detected after transplantation. Read More

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http://dx.doi.org/10.3855/jidc.11842DOI Listing