8,985 results match your criteria Transplants Liver

Comment on: "The role of ex-situ hypothermic oxygenated machine perfusion and cold preservation time in extended criteria DCD and DBD".

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, Turin, Italy.

We read with interest the paper by Dondossola et al.(1) reporting outcomes of 50 liver transplants (LT) performed with extended criteria grafts treated with end-ischemic hypothermic oxygenated machine perfusion (HOPE). Authors brilliantly show that HOPE and normothermic regional perfusion (NRP) after donation after cardiac death (DCD) allow achieving benchmark outcomes even in a challenging setting. Read More

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Solid Organ Transplantation During COVID-19 Pandemic: An International Web-based Survey on Resources' Allocation.

Transplant Direct 2021 Mar 11;7(3):e669. Epub 2021 Feb 11.

Department of Surgery, Oncology and Gastroenterology, Azienda Ospedaliera Universitaria, Padua, Italy.

Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.

Methods: SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Read More

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Why Are There So Many Liver Transplants from Living Donors In Asia And So Few In Europe And The US?

J Hepatol 2021 Jun 7. Epub 2021 Jun 7.

The Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharath Institute of Higher Education & Research, Chennai, India. Electronic address:

Acceptance of liver transplantation (LT) as an established treatment modality for end stage liver disease led an exponential increase in the demand for organs. This had a domino effect on the ever-increasing gap between availability of organs and the sick waiting for it. Interestingly, the west and the east influenced by cultural, socio-economic and other constraints attempted to address this problem of shortage in different ways. Read More

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Mitigation of radiation exposure during surgical hepatectomy after Yttrium-90 radioembolization.

J Radiol Prot 2021 Jun 9. Epub 2021 Jun 9.

Scripps Green Hospital, La Jolla, UNITED STATES.

Background Yttrium-90 (Y-90) radioembolization for the treatment of hepatocellular carcinoma can present safety challenges when transplanting recently treated Y-90 patients. To reduce surgeons' contact with radioactive tissue and remain within occupational dose limits, current guidelines recommend delaying transplants at least 14 days, if possible. We wanted to determine the level of radiation exposure to the transplant surgeon when explanting an irradiated liver before the recommended decay period. Read More

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Anaesthetic implications and transfusion practices in ABO incompatible living donor liver transplantation: Case series.

Indian J Anaesth 2021 Apr 15;65(4):331-335. Epub 2021 Apr 15.

Department of Gastrosurgery and Solid Organ Transplant, Amrita Institute of Medical Sciences, Amrita Vidya Vishwapeetham, Kochi, Kerala, India.

ABO incompatible liver transplants (ABOi LT) are considered as a life-saving option when compatible donor grafts are unavailable. Fourteen adults (right lobe graft) and three children (left lateral segment/lobe) who underwent ABOi LT from living donors between 2011 and 20 period were analysed for transfusions and desensitisation protocols. All recipients received packed red blood cells (PRBC) of their own group. Read More

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[Risk factors of blood loss during liver transplantation in children with biliary atresia and its influence on prognosis].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):491-496

Department of Pediatric Organ Transplantation,Tianjin First Central Hospital,Tianjin 300192,China.

To study the risk factors for massive intraoperative blood loss in children with biliary atresia who underwent liver transplantation for the first time,and to analyze their impacts on graft survival,hospital stay and postoperative complications. The data of 613 children with biliary atresia who underwent liver transplantation at Department of Pediatric Organ Transplantation,Tianjin First Central Hospital from January 2015 to December 2018 were collected and analyzed. There were 270 males and 343 females, aged 7. Read More

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A comparison between combined liver kidney transplants to liver transplants alone: A systematic review and meta-analysis.

Transplant Rev (Orlando) 2021 Jun 1;35(4):100633. Epub 2021 Jun 1.

Department of Surgery, Division of HPB & Transplant Surgery, Erasmus MC University Transplant Institute, Rotterdam, the Netherlands. Electronic address:

Background: Since the introduction of the Model for End-stage Liver disease criteria in 2002, more combined liver kidney transplants are performed. Until 2017, no standard allocation policy for combined liver kidney transplant (CLKT) was available and each transplant center decided eligibility for CLKT or liver transplant alone (LTA) on a case-by-case basis. The aim of this systematic review was to compare the clinical outcomes of CLKT compared to LTA in patients with renal dysfunction. Read More

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The Heterogenous Effect of COVID-19 on Liver Transplantation Activity and Waitlist Mortality in the United States.

Front Surg 2021 18;8:669129. Epub 2021 May 18.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, United States.

The COVID-19 pandemic curtailed the practice of liver transplantation (LT), which lacks a temporizing life-saving measure for candidates on the waitlist. The objective of this research was to (1) determine the effect of decreased LT activity on waitlist mortality in the United States and (2) assess if this effect was homogenous across the country. We conducted a retrospective, cross-sectional analysis utilizing United Network for Organ Sharing (UNOS) data assessing 3,600 liver transplants from January 1, 2020 to June 2, 2020. Read More

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Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation.

Front Immunol 2021 20;12:535012. Epub 2021 May 20.

Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China.

Rejection after organ transplantation is a cause of graft failure. Effectively reducing rejection and inducing tolerance is a challenge in the field of transplantation immunology. The liver, as an immunologically privileged organ, has high rates of spontaneous and operational tolerance after transplantation, allowing it to maintain its normal function for long periods. Read More

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Combined liver-kidney transplantation with positive crossmatch: Role of delayed kidney transplantation.

Surgery 2021 Jun 3. Epub 2021 Jun 3.

Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

Background: Positive crossmatch (XM+) combined liver-kidney transplantation due to preformed donor-specific human leukocyte antigen antibodies has produced mixed results. We sought to understand the role of delayed kidney transplant approach in XM+ combined liver-kidney transplantations.

Methods: XM+ combined liver-kidney transplantations were retrospectively reviewed. Read More

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The impact of the COVID‒19 pandemic on organ donation and transplantation in Hungary in 2020

Orv Hetil 2021 06 6;162(23):890-896. Epub 2021 Jun 6.

2 Semmelweis Egyetem, Általános Orvostudományi Kar, Transzplantációs és Sebészeti Klinika, Budapest.

Összefoglaló. Bevezetés: A SARS-CoV-2-világjárvány terjedése drasztikus változásokat okozott a mindennapi betegellátásban, amelyek érintették a szervadományozás és -átültetés területét is, így csökkent az élő és az elhunyt donorokból történő donációk és transzplantációk száma világszerte. Az esetszám csökkenése mellett a transzplantált és egyben immunszupprimált betegek védelme érdekében további biztonsági intézkedéseket kellett bevezetni. Read More

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[Primary non function of hepatic allograft: 18 years experience of Guillermo Almenara Irigoyen National Hospital - EsSalud].

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):315-321

Departamento de Trasplantes, Hospital Nacional Guillermo Almenara, EsSalud. Lima, Perú.

Introduction: The primary nonfunction of the graft (PNF) after liver transplantation is acute graft failure, in the absence of some causal factor, such as acute thrombosis of the hepatic artery or portal vein.

Objectives: Describe the perioperative characteristics of Liver transplant patients who presented NFPI in the Transplant Department of the Guillermo Almenara Irigoyen Hospital.

Materials And Methods: Retrospective, descriptive and cross-sectional study. Read More

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Evaluation of Clinical Neuropathy After Living Donor Liver Transplant.

Exp Clin Transplant 2021 Jun 3. Epub 2021 Jun 3.

From the Department of Pharmacy, Changhua Christian Hospital, Changhua, Taiwan.

Objectives: Neurologic complications are more common in liver transplants than in other solid-organ transplants. One such neurologic complication, peripheral neuropathy, may cause functional limitations for recipients and have a negative effect on posttransplant quality of life. We aimed to examine the risk factors associated with the occurrence of clinical neuropathy after liver transplant and to investigate the frequency of sensory deficits. Read More

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Intraoperative Factors Associated With Early Recipient Death After Adult-to-Adult Living Donor Liver Transplant.

Exp Clin Transplant 2021 Jun 3. Epub 2021 Jun 3.

From the Department of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, United Kingdom.

Objectives: Living donor liver transplant is the gold standard therapy for patients with terminal hepatic disorders for whom no alternative therapy is available. The primary aim was to assess different intraoperative factors that may predict early death after adult-to-adult living donor liver transplant. The secondary aim was to assess the effect of small-for-size syndrome on mortality. Read More

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Combining Donor and Recipient Age With Preoperative MELD and UKELD Scores for Predicting Survival After Liver Transplantation.

Exp Clin Transplant 2021 Jun;19(6):570-579

From the Department of HPB Surgery and Liver Transplantation, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK; and the Division of Surgery and Interventional Science, University College London, London, UK.

Objectives: The end-stage liver disease scoring systems MELD, UKELD, and D-MELD (donor age × MELD) have had mediocre results for survival assessment after orthotopic liver transplant. Here, we introduced new indices based on preoperative MELD and UKELDscores and assessed their predictive ability on survival posttransplant.

Materials And Methods: We included 1017 deceased donor orthotopic liver transplants that were performed between 2008 (the year UKELD was introduced) and 2019. Read More

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Sequential paternal haploidentical donor liver and HSCT in EPP allow discontinuation of immunosuppression post-organ transplant.

Pediatr Transplant 2021 Jun 2:e14040. Epub 2021 Jun 2.

Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Transplant and Regenerative Medicine Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Background: EPP is characterized by photosensitivity and by liver disease. When LT is performed in EPP, recurrence often occurs in the allograft due to ongoing protoporphyrin production in bone marrow. Therefore, curative treatment requires allogeneic HSCT after LT. Read More

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The impact of hepatitis E infection on hepatic fibrosis in liver transplanted patients for hepatitis C infection.

Braz J Infect Dis 2021 May 29:101587. Epub 2021 May 29.

School of Medicine, Hospital das Clínicas (HCFMUSP), Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Hepatitis E Virus (HEV) is an infection known worldwide for its asymptomatic and self-limited course in most cases. Some cases progressing to chronicity have been described in immunosuppressed patients, especially in recipients of solid organ transplants. We evaluated laboratory parameters of HEV infection (HEV RNA, anti-HEV IgM and anti-HEV IgG) through enzyme-linked immunosorbent assay (Elisa), confirmed by immunoblotting, in a cohort of 294 patients who received liver transplants at the HCFMUSP (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo). Read More

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The Outcomes of Systemic Treatment in Recurrent Hepatocellular Carcinomas Following Liver Transplants.

Adv Ther 2021 Jun 1. Epub 2021 Jun 1.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China.

Background: Treatment of hepatocellular carcinoma (HCC) recurrences following liver transplant (LT) is challenging. Most clinical trials of systemic therapies for advanced HCC excluded patients with any history of organ transplant. We aimed to assess the outcomes in using various systemic therapies in patients with post-LT recurrence. Read More

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Feasibility of Immunoadsorption plasmapheresis in an infant for ABO-incompatible solid organ transplant-A reality.

Pediatr Transplant 2021 May 31:e14064. Epub 2021 May 31.

Division of Paediatric Nephrology, Rainbow Children Hospital, Bangalore, India.

Background: Immunoadsorption (IA) plasmapheresis is standard modality for pretransplant desensitization in ABO-incompatible solid organ transplants though technically challenging when considered for an infant or a child less than 10 kg due to non-availability of pediatric immunoadsorption (IA) columns. The major challenge is to maintain hemodynamic stability considering the large extracorporeal circuit volume meant for adults. To our best knowledge after extensive search in acclaimed global medical journals, this is the first successful attempt in an underweight (6 kg) infant of less than 1 year of age using adult size IA Column thus making it a reality. Read More

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Subhepatic appendix: an ectopic topography not to be disregarded: a case report.

J Med Case Rep 2021 May 31;15(1):288. Epub 2021 May 31.

Department of Surgery, Regional Hospital Center of Maradi, Faculty of Health Sciences of the University of Maradi, Maradi, Niger.

Introduction: Subhepatic appendix is most often due to an anomaly of rotation of the primary intestine occurring during embryogenesis. This ectopic topography associated with advanced age can be a serious diagnosis problem at the stage of appendicitis or appendicular peritonitis.

Case Presentation: We report the case of a 60-year-old melanoderm man, with a history of urinary pathology and peptic ulcer, referred from a health district for abdominal pain of the right hypochondrium evolving for about 5 days, secondarily generalized, in whom we suspected peritonitis, the etiology of which remains to be determined. Read More

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Challenging the Traditional Paradigm of Supply and Demand in Pediatric Liver Transplantation Through Non-Directed Living Donation: A Case Series.

Liver Transpl 2021 May 28. Epub 2021 May 28.

Division of Transplantation, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.

Background: A gap exists between the demand for pediatric liver transplantation and the supply of appropriate size-matched donors. We describe our center's experience with pediatric liver transplantation using anonymous non-directed living liver donors (ND-LLD).

Methods: First-time pediatric liver transplant candidates listed at our center between January 2012 and June 2020 were retrospectively reviewed, categorized by donor graft type, and recipients of ND-LLD grafts were described. Read More

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Right hepatic arterial girdle around the common hepatic duct in liver donors: technical considerations for successful living donor liver transplantation.

Langenbecks Arch Surg 2021 May 28. Epub 2021 May 28.

Institute of Liver Disease and Transplantation, Dr Rela Institute and Medical Centre, Chennai, India.

Purpose: Variations in hepatic arterial anatomy can result in multiple arterial trunks in the graft liver. We describe our experience in dealing with five right lobe liver donors where in the right hepatic artery (RHA) branches were passing anterior and posterior to the common hepatic duct (CHD) forming an arterial girdle around it.

Methods: Five of 771 right lobe living donor liver transplants (January 2012 and March 2020) demonstrated the RHA girdle around the CHD. Read More

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The impact of donor pancreas extraction time on graft survival and postoperative complications in pancreas transplant recipients.

Pancreatology 2021 May 9. Epub 2021 May 9.

Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Simultaneous pancreas kidney transplantation (SPK) is the best therapeutic option for patients with diabetes mellitus type 1 and end-stage renal disease. Recently, donor organ extraction time has been shown to affect kidney and liver graft survival. This study aimed to assess the effect of pancreas donor extraction time on graft survival and postoperative complications. Read More

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Efficacy of Distraction for Reducing Pain and Distress Associated With Venipuncture in the Pediatric Posttransplant Population: A Randomized Controlled Trial.

Pediatr Emerg Care 2021 May 18. Epub 2021 May 18.

From the Division of Pediatric Emergency Medicine, Department of Emergency Medicine Department of Pediatrics Division of Cardiology, Department of Pediatrics Division of Nephrology, Department of Pediatrics Division of Hepatology and Gastroenterology, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY.

Objective: Distraction can reduce pain and distress associated with painful procedures but has never been studied in children with solid organ transplants. We aimed to determine whether there is a difference in pain and distress associated with venipuncture in pediatric posttransplant patients who receive distraction compared with those who do not.

Methods: Randomized controlled trial of children aged 4 to 17 years with solid organ transplants undergoing venipuncture in the outpatient setting. Read More

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The implications of donor-recipient size mismatch in renal transplantation.

J Nephrol 2021 May 25. Epub 2021 May 25.

Department of Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Introduction: Transplanting kidneys small for recipient's size results in inferior graft function. Body surface area (BSA) is related to kidney size. We used the BSA index (BSAi) (Donor BSA/Recipient BSA) to assess whether the renal graft size is sufficient for the recipient. Read More

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Factors Associated With Access to and Receipt of Liver Transplantation in Veterans With End-Stage Liver Disease.

JAMA Intern Med 2021 May 24. Epub 2021 May 24.

Center for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, Palo Alto, California.

Importance: Organ scarcity means few patients with advanced liver disease undergo a transplant, making equitable distribution all the more crucial. Disparities may arise at any stage in the complex process leading up to this curative therapy.

Objective: To examine the rate of and factors associated with referral, wait-listing, and receipt of liver allografts. Read More

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Recurrence of primary sclerosing cholangitis after liver transplantation - analysing the European Liver Transplant Registry and beyond.

Transpl Int 2021 May 24. Epub 2021 May 24.

Erasmus MC Transplant Institute, Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post-transplant rPSC on graft and patient survival in a large European cohort. Read More

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Impact of Anesthesiologist Experience on Early Outcomes in Adult Orthotopic Liver Transplantation.

Transplant Proc 2021 May 18. Epub 2021 May 18.

Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, South Carolina.

Background: Liver transplantation is a complex surgical procedure. The experience of the anesthesiologist, and its potential relationship to patient morbidity and mortality, is yet to be determined. We sought to explore this possible association using our institutional training patterns as the subject of study. Read More

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Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs.

Stem Cell Res Ther 2021 May 19;12(1):292. Epub 2021 May 19.

Recombinetics Inc., Stem Cell Technologies, 3388 Mike Collins Drive, Eagan, MN, 55121, USA.

Background: There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue that can for therapeutic use in patients. Blastocyst complementation is a challenging, innovative technology that could fundamentally change the future of organ transplantation. Read More

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