7,545 results match your criteria Transplants Liver


Implementation of a Strongyloides Screening Strategy in Solid Organ Transplant Donors and Recipients.

Clin Transplant 2019 Feb 17:e13497. Epub 2019 Feb 17.

Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Strongyloides stercoralis infects 100 million people worldwide. Mortality rates in hyperinfection syndrome exceed 50%. Donor-derived Strongyloides infection has occurred after heart, kidney, kidney-pancreas and liver transplantation; yet, only 10% of the U. Read More

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http://dx.doi.org/10.1111/ctr.13497DOI Listing
February 2019

The peculiar aging of human liver: A geroscience perspective within transplant context.

Ageing Res Rev 2019 Feb 14. Epub 2019 Feb 14.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; CIG-Interdepartmental Center "Galvani", University of Bologna, Bologna, Italy; CSR-Centro di Studio per la Ricerca dell'Invecchiamento, University of Bologna, Bologna, Italy.

An appraisal of recent data highlighting aspects inspired by the new Geroscience perspective are here discussed. The main findings are summarized as follows: i) liver has to be considered an immunological organ, and new studies suggest a role for the recently described cells named telocytes; ii) the liver-gut axis represents a crucial connection with environment and life style habits and may influence liver diseases onset; iii) the physiological aging of liver shows relatively modest alterations. Nevertheless, several molecular changes appear to be relevant: a) an increase of microRNA-31-5p; -141-3p; -200c-3p expressions after 60 years of age; b) a remodeling of genome-wide DNA methylation profile evident until 60 years of age and then plateauing; c) changes in transcriptome including the metabolic zones of hepatocyte lobules; d) liver undergoes an accelerated aging in presence of chronic inflammation/liver diseases in a sort of continuum, largely as a consequence of unhealthy life styles and exposure to environmental noxious agents. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.002DOI Listing
February 2019

Safety and Efficacy of Transjugular Liver Biopsy in Patients with Left Lobe-Only Liver Transplants.

J Vasc Interv Radiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-361, San Francisco, CA 94143.

Purpose: To evaluate efficacy and safety of transjugular liver biopsy (TJLB) via the left hepatic vein in patients with left lobe-only liver transplants (LLOTs).

Materials And Methods: Retrospective review revealed 43 TJLBs performed in 26 patients with LLOTs (mean age 51.3 y; range, 18-73 y) between January 2009 and June 2016 at a single institution. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.07.026DOI Listing
February 2019

Current status of graft-versus-host disease after intestinal transplantation.

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Transplantation, Department of Surgery, Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Thomas E. Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.

Purpose Of Review: Over the past decades, visceral transplantation has become the standard of care for patients with irreversible intestinal failure who suffer complications of total parenteral nutrition (TPN). Graft-versus-host disease (GVHD) after solid organ transplantation is a rare but often fatal complication with high mortality. GVHD after intestinal transplantation, given the large lymphoid content of the graft, is more frequent compared with other solid organs. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000624DOI Listing
February 2019
5 Reads

Assessment of Trends in Transplantation of Liver Grafts From Older Donors and Outcomes in Recipients of Liver Grafts From Older Donors, 2003-2016.

JAMA Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: In light of the growing population of older adults in the United States, older donors (aged ≥70 years) represent an expansion of the donor pool; however, their organs are underused. Liver grafts from older donors were historically associated with poor outcomes and higher discard rates, but clinical protocols, organ allocation, and the donor pool have changed in the past 15 years.

Objective: To evaluate trends in demographics, discard rates, and outcomes among older liver donors and transplant recipients of livers from older donors in a large national cohort. Read More

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http://dx.doi.org/10.1001/jamasurg.2018.5568DOI Listing
February 2019

A Case of Donor-Transmitted Non-Small Cell Lung Cancer After Liver Transplantation: An Unwelcome Guest.

Oncologist 2019 Feb 12. Epub 2019 Feb 12.

Mayo Clinic Cancer Center, Phoenix, Arizona, USA

Cancer transmission with organ donation has been previously reported with a variety of malignancies and organ transplants. The risk of transmission through organ transplantation from donors with a history of previously treated malignancies has been addressed by guidelines from transplant societies. Herein, we report a case of a patient who developed lung cancer confined to the liver after liver transplantation with no known history of malignancy in the donor. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0517DOI Listing
February 2019

Influence of the Procurement Surgeon on Transplanted Abdominal Organ Outcomes: an SRTR Analysis to Evaluate Regional Organ Procurement Collaboration.

Am J Transplant 2019 Feb 12. Epub 2019 Feb 12.

Division of Transplantation, Department of Surgery.

Single-center studies have demonstrated regional organ procurement collaboration to reduce travel redundancy and improve procurement efficiency. We studied deceased donor kidney, liver, and pancreas transplants performed in the U.S. Read More

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http://dx.doi.org/10.1111/ajt.15301DOI Listing
February 2019
1 Read

Hypothermic Oxygenated Perfusion (HOPE) - A simple and effective method to modulate the immune response in kidney transplantation.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

Department of Surgery and Transplantation, Swiss HPB Centre, University Hospital Zurich, Switzerland.

Background: Hypothermic oxygenated perfusion (HOPE) has been shown to protect liver recipients from acute rejection in an allogeneic model of liver transplantation in rats. Here we investigate the impact of HOPE on the T-Cell mediated immune response following kidney transplantation.

Methods: Kidneys from Lewis rats were transplanted into Brown Norway recipients to trigger acute rejection (allogeneic untreated group). Read More

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http://dx.doi.org/10.1097/TP.0000000000002634DOI Listing
February 2019

Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Gastroenterology, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address:

Background & Aims: The incidence and outcomes of alanine aminotransferase (ALT) flares during the natural history of chronic HBV infection has not been determined in a large, racially heterogeneous groups of patients in North America.

Methods: We collected data from the Hepatitis B Research Network-an observational cohort study of untreated adults with chronic HBV infection enrolled at 21 sites in the United States and Canada. Clinical and laboratory data were collected from 1587 participants (49. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.005DOI Listing
February 2019
1 Read

Impact of a Multidisciplinary Team on Alcohol Recidivism and Survival After Liver Transplant for Alcoholic Disease.

Transplant Proc 2019 Jan - Feb;51(1):187-189. Epub 2018 Jun 30.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Background: Alcohol use disorders have a prevalence of 10% among the population of the United States and Europe and are one of the most frequent causes of liver cirrhosis in the Western world. Currently, alcohol-related liver cirrhosis represents one of the most frequent indications to liver transplant (LT), both as independent cause or associated with hepatitis C virus or hepatitis B virus infections. Starting from 2014, a multidisciplinary team involving surgeons, gastroenterologists, clinical toxicologists, psychiatrists, and psychologists was developed within the Modena Liver Transplant Center. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.212DOI Listing
June 2018
1 Read

Liver Transplant in Colombia.

Liver Transpl 2019 Feb 8. Epub 2019 Feb 8.

Liver Transplant Program, Hospital Pablo Tobon Uribe, Professor University of Antioquia, Gastrohepatology group member, University of Antioquia, Medellin, Colombia.

Liver transplants (LTs) began in Colombia in 1979. Between 1999 and 2017, 3,081 LTs were performed, occupying fourth place in Latin America in 2017 after Brazil, Argentina, and Uruguay, with a rate of 5.6 LTs per million population (pmp). Read More

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http://dx.doi.org/10.1002/lt.25427DOI Listing
February 2019

Promising potentials of Tibetan macaques in xenotransplantation.

Xenotransplantation 2019 Jan 8;26(1):e12489. Epub 2019 Feb 8.

Organ Transplant and Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.

Organ transplantation is a crucial medical procedure, as it is often the only treatment for patients suffering from end-stage organ failure. Unfortunately, the shortage of donor organs limits the number of patients whose lives can be saved. Carrying out research on xenotransplantation with the aim of eventually replacing human organ transplants with those of animals is very promising, as it could effectively bridge the shortfall in donor organs. Read More

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http://dx.doi.org/10.1111/xen.12489DOI Listing
January 2019

Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver Kidney Transplants: Thymoglobulin Induction Is Not Harmful.

Liver Transpl 2019 Feb 7. Epub 2019 Feb 7.

Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

We read with great interest the article by AbdulRahim et al. , which studied the impact of induction therapy on patient survival following combined liver-kidney transplantation (CLKT). The article included national data from 2002-2016 analyzing 4722 CLKTs: (i) no-induction (n=2333), (ii) IL2RA induction (n=1558), and (iii) r-ATG induction (n=831). Read More

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http://dx.doi.org/10.1002/lt.25428DOI Listing
February 2019

Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology and Kidney Transplantation, Beaumont Hospital Dublin, Ireland.

Importance: Existing data suggest that nonmelanoma skin cancer (NMSC) is more common in renal transplant recipients than in maintenance dialysis patients. However, whether the risk of NMSC varies as the treatment modality for end-stage kidney disease (ESKD) changes between dialysis and transplantation is not well described.

Objective: To determine whether the incidence of NMSC is attenuated during periods of graft loss with a return to dialysis in those who receive multiple kidney transplants. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4660DOI Listing
February 2019
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[Liver transplantation in a patient with human immunodeficiency virus (HIV). Case report].

Rev Med Chil 2018 Dec;146(10):1215-1219

Programa Trasplante Hepático, Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.

Abstrac: Before the advent of highly active antiretroviral therapy (HAART), patients infected with human immunodeficiency virus (HIV) were considered as having an absolute contraindication for liver transplantation (LT). Considering the increased life expectancy in HIV positive patients under HAART and the improvements in the management of graft recipients, these patients are now suitable for carrying out transplants in selected cases. We report a 26 years old HIV positive male who developed acute liver failure possibly caused by drug induced liver injury who underwent a successful liver transplantation. Read More

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http://dx.doi.org/10.4067/S0034-98872018001001215DOI Listing
December 2018
1 Read

The Impact of Increased Allocation Priority for Children Awaiting Liver Transplant: A Liver Simulated Allocation Model (LSAM) Analysis.

J Pediatr Gastroenterol Nutr 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatrics, University of Washington, Seattle, WA.

Objective: To investigate the impact of prioritizing infants, children, adolescents and the sickest adults (Status 1) for deceased donor livers. We compared outcomes under two "SharePeds" allocation schema, which prioritize children and Status 1 adults for national sharing and enhanced access to (1) pediatric donors or (2) all donors <35 years old, to outcomes under the allocation plan approved by the Organ Procurement and Transplant Network in December 2017 (OPTN 12-2017).

Methods: The 2017 Liver Simulated Allocation Model (LSAM) and Scientific Registry of Transplant Recipients (SRTR) data on all U. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002287DOI Listing
January 2019

Loco-regional HCC treatment services as a bridge to liver transplantation.

Hepatobiliary Pancreat Dis Int 2019 Jan 21. Epub 2019 Jan 21.

Department of General-, Visceral- and Transplantation Surgery, University Hospital of RWTH Aachen, Aachen, Germany; Department of Surgery, Charité - University Medicine at Berlin, Germany. Electronic address:

Background: Liver transplantation remains the main curative treatment option for hepatocellular carcinoma (HCC) patients. In the Eurotransplant area Milan criteria are used to assign priority extra points (exceptional MELD, exMELD) for patients on the waiting list. To prevent patients from tumor progression, loco-regional (neoadjuvant) treatment (LRT) is used. Read More

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http://dx.doi.org/10.1016/j.hbpd.2019.01.004DOI Listing
January 2019
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Improved Graft Survival after Liver Transplantation for Recipients with Hepatitis C in the Direct-acting Antiviral Era.

Liver Transpl 2019 Feb 4. Epub 2019 Feb 4.

Center for Liver Diseases, The University of Chicago Medicine, Chicago, IL, USA.

Background: Highly effective direct acting antiviral (DAA) therapy has transformed outcomes of liver transplantation in HCV patients. We examined longer-term outcomes in HCV-positive recipients in the DAA era.

Methods: We analyzed the Scientific Registry of Transplant Recipients (SRTR) for primary adult, single organ, non-fulminant liver transplant recipients in the US from January 1, 2008, to June 30, 2018. Read More

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http://dx.doi.org/10.1002/lt.25424DOI Listing
February 2019
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De novo leukocyte chemotactic factor 2 amyloidosis in a pediatric renal allograft, 15 years post-transplant.

Pediatr Transplant 2019 Feb 3:e13371. Epub 2019 Feb 3.

Department of Pathology, University of California San Francisco, San Francisco, California.

Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a recently described form of systemic amyloidosis, which most commonly affects the kidney and liver. The LECT2 protein is produced during inflammatory processes, but its precise function in renal diseases in unclear. ALECT2, however, is known to be a relatively common form of renal amyloidosis, after amyloid light chain and serum amyloid A types and is most often seen in patients of Hispanic ethnicity. Read More

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http://dx.doi.org/10.1111/petr.13371DOI Listing
February 2019

Increasing Utilization and Excellent Initial Outcomes Following Liver Transplant of HCV-Viremic Donors into HCV-Negative Recipients.

Hepatology 2019 Jan 31. Epub 2019 Jan 31.

Center for Liver Diseases, The University of Chicago Medicine, Chicago, IL, USA.

Background & Aims: Direct-acting antiviral (DAA) therapy has altered the frequency and outcome of liver transplantation for hepatitis C virus (HCV). The high efficacy and tolerability of DAA therapy has also created a rationale for utilizing HCV-viremic (HCV-RNA-positive) donors, including into HCV-negative recipients. We examined trends in the frequency of organ utilization and graft survival in recipients of HCV-viremic donors (HCV-RNA-positive as measured by Nucleic Acid Testing, NAT). Read More

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http://dx.doi.org/10.1002/hep.30540DOI Listing
January 2019
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Assessment of muscle mass depletion in chronic liver disease; dual-energy x-ray absorptiometry compared with computed tomography.

Nutrition 2018 Nov 14;61:93-98. Epub 2018 Nov 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objectives: The aim of this study was to perform intermethod comparisons between the following three measures of muscle mass depletion in patients eligible for liver transplantation: 1) fat-free mass index (FFMI) measured by dual-energy x-ray absorptiometry (DXA), 2) appendicular skeletal muscle mass index (ASMI) measured by DXA, and 3) skeletal muscle index (SMI) measured at the third lumbar level by computed tomography (CT).

Methods: The medical records of patients who received liver transplants between 2009 and 2012 at Karolinska University Hospital were retrospectively reviewed. Adult patients with a chronic liver disease who had both DXA and CT scans performed within a 30-d period during their pretransplant workup were included. Read More

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http://dx.doi.org/10.1016/j.nut.2018.10.031DOI Listing
November 2018
2.926 Impact Factor

Animal model simulation for training with split-liver transplants.

Authors:
Jonathan Fryer

Liver Transpl 2019 Jan 29. Epub 2019 Jan 29.

Surgery and Organ Transplantation, Chicago, Illinois, United States.

Split liver transplantation is a strategy that enhances the availability of organ transplants (1)by potentially providing liver transplants for 2 patients from a single deceased donor (2). However, because of its complexity, most programs have not embraced this strategy. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/lt.25418DOI Listing
January 2019

"Real-time" risk models of postoperative morbidity and mortality for liver transplants.

Ann Gastroenterol Surg 2019 Jan 2;3(1):75-95. Epub 2018 Nov 2.

Japanese Society of Gastroenterological Surgery Tokyo Japan.

Aim: A comprehensive description of morbidity and mortality risk factors for post liver transplant has not been available to date. In this study, we established real-time risk models of postoperative morbidities and mortality in liver transplant recipients using two Japanese nationwide databases.

Methods: Data from two Japanese nationwide databases were combined and used for this study. Read More

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http://dx.doi.org/10.1002/ags3.12217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345648PMC
January 2019

Recipient obesity does not affect survival after deceased donor liver transplantation for hepatocellular carcinoma. A national retrospective cohort study in the United States.

HPB (Oxford) 2019 Jan 7;21(1):67-76. Epub 2018 Jul 7.

Division of Transplant Surgery, University of Pittsburgh Medical Centre, Pittsburgh, PA, USA. Electronic address:

Background: The oncological effects of obesity on liver transplant (LT) patients with hepatocellular carcinoma (HCC) remains unclear. We investigated patient overall survival and tested two-way interactions between donor and recipient obesity status.

Methods: Using the UNOS database, a total of 8352 LT recipients with HCC were included. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.06.1797DOI Listing
January 2019

Liver histopathological findings in advanced heart failure: a reappraisal of cardiac cirrhosis concept.

Intern Emerg Med 2019 Jan 28. Epub 2019 Jan 28.

Internal Medicine, University of Campania 'L. Vanvitelli', Naples, Italy.

Cardiogenic liver disease is a common yet poorly characterized complication of advanced heart failure (HF), and may impact clinical management in the setting of heart transplant evaluation. In this retrospective study, we describe clinical and histopathological features of liver injury in advanced HF, with a focus on the role of liver biopsy. Included were 45 HF patients, assessed for possible heart transplant, who underwent liver biopsy for suspected liver disease. Read More

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http://dx.doi.org/10.1007/s11739-019-02033-3DOI Listing
January 2019
1 Read

The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD).

Cell Mol Life Sci 2019 Jan 25. Epub 2019 Jan 25.

Micalis Institute, INRA, UMR1319, Equipe AMIPEM, AgroParisTech, Université Paris-Saclay, Building 442, Domaine de Vilvert, 78350, Jouy-en-Josas, France.

NAFLD is currently the main cause of chronic liver disease in developed countries, and the number of NAFLD patients is growing worldwide. NAFLD often has similar symptoms to other metabolic disorders, including type 2 diabetes and obesity. Recently, the role of the gut microbiota in the pathophysiology of many diseases has been revealed. Read More

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http://dx.doi.org/10.1007/s00018-019-03011-wDOI Listing
January 2019
1 Read

Self-management in liver transplantation.

Appl Nurs Res 2019 Feb 7;45:30-38. Epub 2018 Nov 7.

School of Nursing, University of Wisconsin-Madison, 701 Highland Ave., Room 4187, Madison, WI 53705, United States of America. Electronic address:

Background: Self-management is crucial for liver transplant (LT) recipients to maintain transplants and optimize health outcomes. However, previous literature has been primarily limited to examining medication adherence; there is a knowledge gap regarding self-management in the LT population.

Aim: The aims of this study were to 1) comprehensively describe self-management behaviors and activities in LT recipients, 2) explore levels of overall self-management, and 3) explore the relationships of self-efficacy, cognition, and health information seeking behavior with self-management. Read More

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http://dx.doi.org/10.1016/j.apnr.2018.11.002DOI Listing
February 2019

Microelimination of chronic hepatitis C in Switzerland: modelling the Swiss Hepatitis Strategy goals in eastern, western and northern regions.

Swiss Med Wkly 2019 Jan 23;149:w14694. Epub 2019 Jan 23.

Division of Gastroenterology and Hepatology, Cantonal Hospital St Gallen, Switzerland.

Background And Aims: Direct-acting antiviral agents have revolutionised hepatitis C treatment. In 2014, the Swiss Hepatitis Strategy was developed to eliminate hepatitis C virus (HCV) infection and the associated liver-related morbidity and mortality by 2030. Though numerous national studies and assessments have identified a relatively low prevalence rate of 0. Read More

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https://doi.emh.ch/smw.2019.14694
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http://dx.doi.org/10.4414/smw.2019.14694DOI Listing
January 2019
2 Reads

Long Term Survival in Visceral Transplant Recipients in the New Era: A Single Center Experience.

Am J Transplant 2019 Jan 23. Epub 2019 Jan 23.

MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC.

There is a paucity of data on long-term outcomes following visceral transplantation in the contemporary era. This is a single-center retrospective analysis of all visceral allograft recipients who underwent transplant between November 2003 and December 2013 with at least 3-year follow up data. Clinical data from a prospectively maintained database was used to assess outcomes including patient and graft survival. Read More

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http://dx.doi.org/10.1111/ajt.15269DOI Listing
January 2019
3 Reads

National Trends and Long-term Outcomes of Liver Transplant for Alcohol-Associated Liver Disease in the United States.

JAMA Intern Med 2019 Jan 22. Epub 2019 Jan 22.

Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco.

Importance: Alcohol-associated liver disease (ALD) has emerged as the most common indication for liver transplant in the United States, but data on the reasons for this increase and long-term post-liver transplant outcomes among liver transplant recipients are sparse.

Objective: To characterize trends and long-term outcomes of liver transplant for ALD in the United States between 2002 and 2016.

Design, Setting, And Participants: This multicenter, prospective, national cohort study used data from the United Network for Organ Sharing database to evaluate all liver transplants performed in the United States between January 1, 2002, and December 31, 2016. Read More

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http://dx.doi.org/10.1001/jamainternmed.2018.6536DOI Listing
January 2019

"Bright Band Sign" A Grayscale Ultrasound Finding in Hepatic Infarction.

J Ultrasound Med 2019 Jan 21. Epub 2019 Jan 21.

Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Hepatic infarction is infrequent due to the dual blood supply of the liver and the compensatory relationship between the hepatic artery and portal vein. Most cases occur in liver transplants due to vascular complications. Grayscale sonography combined with color and spectral wave Doppler can assess for vessel patency and parenchymal abnormalities. Read More

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http://dx.doi.org/10.1002/jum.14939DOI Listing
January 2019

Kidney Transplantation in Elderly Recipients: A Single-Center Experience.

Transplant Proc 2019 Jan - Feb;51(1):132-135. Epub 2018 Jun 30.

Department of Medicine, Kidney & Liver Transplantation Academic University Hospital, P. le S.M della Misericordia, Udine, Italy.

In this retrospective single-center study we evaluated the outcome after kidney transplant in recipients older than 65 years in terms of patient and graft survival and causes of death.

Patients And Methods: From 1993 to 2016, 109 consecutive first single kidney transplants in recipients older than 65 years were included. Furthermore, 2 age groups have also been identified (group A, 65-70 years old vs group B, 71-76 years old). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.081DOI Listing
June 2018
1 Read

Hepaticojejunostomy in Orthotopic Liver Transplant: A Retrospective Case Control Study.

Transplant Proc 2019 Jan - Feb;51(1):58-61. Epub 2018 Jun 30.

Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital, Bilbao, Spain.

The reported biliary morbidity rate for deceased donor full-size orthotopic liver transplantation is up to 30%. The technique used may be influenced by multiple factors, and in some situations, biliary reconstruction must be carried out through Roux-en-Y hepaticojejunostomy. The aim of our study was to determine the results of the orthotopic liver transplantation according to the technique used in the biliary reconstruction. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.135DOI Listing
June 2018
1 Read

How Do Hepatologists Gain Access to Liver Transplant Units?

Transplant Proc 2019 Jan - Feb;51(1):38-40. Epub 2018 Jun 28.

Liver Transplant Unit, A Coruña Hospital, A Coruña, Spain.

Liver transplantation has evolved from an experimental treatment to be considered as the most effective therapy for end-stage liver disease and selected cases of hepatocellular carcinoma. Transplant hepatologists must have specific knowledge and abilities to treat those patients who receive a liver transplant. In Spain, approximately 1100 liver transplants are performed each year, and most centers assume both postoperative care and long-term follow-up, which has led to a significant work load in liver transplant units. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.207DOI Listing
June 2018
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Liver Transplant From Controlled Cardiac Death Donors Using Normothermic Regional Perfusion: Comparison With Liver Transplants From Brain Dead Donors.

Transplant Proc 2019 Jan - Feb;51(1):12-19. Epub 2018 Jun 28.

Department of General Surgery, University Hospital "Marqués de Valdecilla," Santander, Spain.

Background: Liver transplantation from donors after either controlled or uncontrolled cardiac death (DCD) is associated with considerable rates of primary nonfunction (PNF) and ischemic cholangiopathy (IC). Normothermic regional perfusion (NRP) could significantly reduce such rates.

Methods: Retrospective study to analyze short-term (mortality, PNF, vascular complications) and long-term (IC, survival) complications in 11 liver transplants from controlled DCDs using NRP with extracorporeal membrane oxygenation (ECMO) (group 1). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.067DOI Listing
June 2018
6 Reads

The role of complement in liver injury, regeneration and transplantation.

Hepatology 2019 Jan 17. Epub 2019 Jan 17.

Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.

The liver is both an immunologically complex and privileged organ. The innate immune system is a central player, and the complement system emerges as a pivotal part of liver homeostasis, in immune responses, and cross-talk with other effector systems in both innate and adaptive immunity. The liver produces the majority of the complement proteins and is the home of important immune cells like the Kupffer cells. Read More

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http://dx.doi.org/10.1002/hep.30508DOI Listing
January 2019
1 Read

Adult liver transplantation in Johannesburg, South Africa (2004 - 2016): Balancing good outcomes, constrained resources and limited donors.

S Afr Med J 2018 Oct 26;108(11):929-936. Epub 2018 Oct 26.

Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Liver transplantation is the standard of care for the treatment of liver failure worldwide, yet millions of people living in sub-Saharan Africa remain without access to these services. South Africa (SA) has two liver transplant centres, one in Cape Town and the other in Johannesburg, where Wits Donald Gordon Medical Centre (WDGMC) started an adult liver transplant programme in 2004.

Objectives:  To describe the outcomes of the adult liver transplant programme at WDGMC. Read More

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http://www.samj.org.za/index.php/samj/article/view/12463
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http://dx.doi.org/10.7196/SAMJ.2018.v108i11.13286DOI Listing
October 2018
6 Reads

Risk factors associated with mortality in neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and clinical implications.

BMC Pediatr 2019 Jan 14;19(1):18. Epub 2019 Jan 14.

Department of Hepatology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) has high prevalence in East Asia, and has been reported in other parts of the world. NICCD is also the most common form of genetic cholestasis among East Asians. There has been reports of mortalities or liver transplants associated with NICCD, but risk factors associated with poor outcome were unknown. Read More

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http://dx.doi.org/10.1186/s12887-018-1383-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330752PMC
January 2019
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1.918 Impact Factor

Survival advantage for patients accepting the offer of a circulatory death liver transplant.

J Hepatol 2019 Jan 10. Epub 2019 Jan 10.

University Department of Surgery, Addenbrooke's Hospital, Hill Road, Cambridge, CB2 0QQ, United Kingdom. Electronic address:

Background & Aims: Donation after circulatory death (DCD) in the UK has tripled in the last decade. However, outcomes following DCD liver transplantation are poorer than for brain-stem death (DBD) liver transplants. This study examines whether a recipient to should accept a "poorer quality" DCD organ, or wait longer for a "better" DBD organ. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.12.033DOI Listing
January 2019
1 Read

Clinical features and determinants of chronicity in hepatitis E virus infection.

J Viral Hepat 2019 Jan 12. Epub 2019 Jan 12.

Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland.

Hepatitis E virus (HEV) has traditionally been associated with an acute, self-limiting hepatitis and is not known to have any chronic sequelae. HEV genotypes 1 and 2, which are human pathogens, have been associated with this self-limiting presentation, in both sporadic and epidemic settings. HEV genotype 3, which is zoonotically transmitted, is increasingly being reported as a cause of chronic infection in immunocompromised patients. Read More

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http://doi.wiley.com/10.1111/jvh.13059
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http://dx.doi.org/10.1111/jvh.13059DOI Listing
January 2019
5 Reads

Safety of hepatitis B virus core antibody-positive grafts in liver transplantation: A single-center experience in China.

World J Gastroenterol 2018 Dec;24(48):5525-5536

Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Given the shortage of suitable liver grafts for liver transplantation, proper use of hepatitis B core antibody-positive livers might be a possible way to enlarge the donor pool and to save patients with end-stage liver diseases. However, the safety of hepatitis B virus core antibody positive (HBcAb) donors has been controversial. Initial studies were mainly conducted overseas with relatively small numbers of HBcAb liver recipients, and there are few relevant reports in the population of mainland China. Read More

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http://dx.doi.org/10.3748/wjg.v24.i48.5525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319134PMC
December 2018
2 Reads

Post-transplant diabetes mellitus in patients with solid organ transplants.

Nat Rev Endocrinol 2019 Mar;15(3):172-188

Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.

Solid organ transplantation (SOT) is a life-saving procedure and an established treatment for patients with end-stage organ failure. However, transplantation is also accompanied by associated cardiovascular risk factors, of which post-transplant diabetes mellitus (PTDM) is one of the most important. PTDM develops in 10-20% of patients with kidney transplants and in 20-40% of patients who have undergone other SOT. Read More

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http://www.nature.com/articles/s41574-018-0137-7
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http://dx.doi.org/10.1038/s41574-018-0137-7DOI Listing
March 2019
8 Reads

Living donor liver transplantation with two-stage hepatectomy for patients with isolated, irresectable colorectal liver-the LIVER-T(W)O-HEAL study.

World J Surg Oncol 2019 Jan 8;17(1):11. Epub 2019 Jan 8.

Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747, Jena, Germany.

Background: Colorectal cancer is the third most common malignancy worldwide. The occurrence of liver metastases worsens the prognosis of the patient significantly if the tumor burden is not resectable. Liver transplantation might be an option for otherwise irresectable colorectal liver metastases. Read More

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http://dx.doi.org/10.1186/s12957-018-1549-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325801PMC
January 2019
3 Reads

Reply: Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver Kidney Transplants.

Liver Transpl 2019 Jan 7. Epub 2019 Jan 7.

UT Southwestern Medical Center, Dallas, TX.

We thank Ekser et al. for sharing their experience with thymoglobulin as induction therapy in their population of simultaneous liver kidney transplant (SLKT) patients. The purpose of their study was to ascertain if differences in KDPI or delayed kidney transplant (KT) leads to improvement in patient survival. Read More

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http://dx.doi.org/10.1002/lt.25407DOI Listing
January 2019

Long-term Outcomes of Autologous Peripheral Blood Stem Cell Transplantation in Patients With Cirrhosis.

Clin Gastroenterol Hepatol 2018 Oct 26. Epub 2018 Oct 26.

Department of Gastroenterology, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China; National Clinical Research Center for Digestive Diseases, Xi'an, People's Republic of China. Electronic address:

Background & Aims: Peripheral blood stem cells (PBSCs) mobilized with colony-stimulating factor can promote liver regeneration and increase liver function in patients with liver diseases. However, the long-term effects of stem cell treatments on survival and risk of hepatocellular carcinoma (HCC) in patients with cirrhosis have not been determined. We investigated the long-term effects of autologous stem cell transplantation and risk of HCC in patients with cirrhosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183119
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http://dx.doi.org/10.1016/j.cgh.2018.10.034DOI Listing
October 2018
6 Reads

Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand.

Liver Transpl 2019 Jan;25(1):25-34

Medical School, University of Western Australia, Nedlands, Australia.

The worldwide increase in obesity and diabetes has led to predictions that nonalcoholic steatohepatitis (NASH) will become the leading indication for orthotopic liver transplantation (OLT). Data supporting this prediction from outside the United States are limited. Thus, we aimed to determine trends in the frequency of NASH among adults listed and undergoing OLT in Australia and New Zealand (ANZ) from 1994 to 2017. Read More

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http://doi.wiley.com/10.1002/lt.25361
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http://dx.doi.org/10.1002/lt.25361DOI Listing
January 2019
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How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Pathology Unit, S. Orsola-Malpighi University Hospital of Bologna, Bologna, Italy.

Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Read More

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http://dx.doi.org/10.1007/s40620-018-00573-zDOI Listing
January 2019

Pilot evaluation of PD-1 inhibition in metastatic cancer patients with a history of liver transplantation: the Mayo Clinic experience.

J Gastrointest Oncol 2018 Dec;9(6):1054-1062

Division of Hematology & Oncology, Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Background: Patients with solid organ transplants (SOTs) have been excluded from programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitor clinical trials due to concern for allograft rejection. The use of immune checkpoint inhibitor therapy remains controversial in transplant patients.

Methods: A retrospective pilot evaluation was conducted to assess the safety and efficacy of PD-1 inhibitors in patients with liver transplantation (LT). Read More

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http://dx.doi.org/10.21037/jgo.2018.07.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286929PMC
December 2018
2 Reads

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection.

Antiviral Res 2019 Feb 30;162:136-141. Epub 2018 Dec 30.

Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, 67000, Strasbourg, France; Université de Strasbourg, 67000, Strasbourg, France; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Institut Universitaire de France, Paris, France. Electronic address:

Despite the development of direct-acting antivirals (DAAs), hepatitis C virus (HCV) infection remains a major cause for liver disease and cancer worldwide. Entry inhibitors block virus host cell entry and, therefore, prevent establishment of chronic infection and liver disease. Due to their unique mechanism of action, entry inhibitors provide an attractive antiviral strategy in organ transplantation. Read More

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http://dx.doi.org/10.1016/j.antiviral.2018.12.018DOI Listing
February 2019
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Split liver transplantation: Current developments.

World J Gastroenterol 2018 Dec;24(47):5312-5321

Department of Surgery, University Hospital Regensburg, Regensburg 93053, Germany.

In 1988, Rudolf Pichlmayr pioneered split liver transplantation (SLT), enabling the transplantation of one donor liver into two recipients - one pediatric and one adult patient. In the same year, Henri Bismuth and colleagues performed the first full right/full left split procedure with two adult recipients. Both splitting techniques were rapidly adopted within the transplant community. Read More

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http://dx.doi.org/10.3748/wjg.v24.i47.5312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305537PMC
December 2018
1 Read