9,573 results match your criteria Transplants Liver

Children undergoing early liver re-transplantation for primary non-function have improved survival.

Pediatr Transplant 2022 Jun 25:e14347. Epub 2022 Jun 25.

Department of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Background: Primary non-function (PNF) in the early post-LT period in children leads to prolonged hospitalization, high graft loss, and significant mortality. However, there is a paucity of data available on the natural history of children relisted for LT due to PNF, including those who recover graft function and survive with their original allograft.

Methods: We interrogated the United Network of Organ Sharing (UNOS) database for pediatric LT recipients who were relisted with a primary diagnosis of PNF from 2000 to 2020. Read More

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Heart Transplantation, Either Alone or Combined With Liver and Kidney, a Viable Treatment Option for Selected Patients With Severe Cardiac Amyloidosis.

Transplant Direct 2022 Jul 17;8(7):e1323. Epub 2022 Jun 17.

French National Referral Centre for Cardiac Amyloidosis, Créteil, France.

Heart transplantation in cardiac amyloidosis (CA) patients is possible and generally considered for transplantation if other organs are not affected. In this study, we aimed to describe and assess outcome in patients following heart transplantations at our CA referral center.

Methods: We assessed all CA patients that had heart transplantations at our center between 2005 and 2018. Read More

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Superb Microvascular Imaging (SMI) Compared with Color Doppler Ultrasound for the Assessment of Hepatic Artery in Pediatric Liver Transplants: A Feasibility Study.

Diagnostics (Basel) 2022 Jun 16;12(6). Epub 2022 Jun 16.

Department of Radiology, Papa Giovanni XXIII Hospital, Piazza OMS 1, 24127 Bergamo, BG, Italy.

(1) Background: Despite progression in surgical techniques and immunological treatments, hepatic artery (HA) thrombosis and stenosis still develop as an early or late liver transplant (LT) complication. We aimed to compare superb microvascular imaging (SMI) with conventional Doppler imaging (CDI) in the assessment of HA in a cohort of pediatric patients undergoing follow-up ultrasound (US) for LT. (2) Methods: This prospective, observational study included 73 pediatric LT recipients (median age, 7 years; IQR, 5. Read More

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Clinical Considerations and Outcomes for Spine Surgery Patients with a History of Transplant: A Systematic Scoping Review Protocol.

Methods Protoc 2022 Jun 5;5(3). Epub 2022 Jun 5.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Spine surgery patients with a history of organ transplantation are a complex population due to their unique anesthetic considerations, immunologic profiles, drug interactions, and potential organ dysfunction. It is common for these patients to develop neck/back pain and pathology that warrants surgical intervention. However, there is a relative dearth of literature examining their outcomes and clinical considerations. Read More

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Progress with RNA Interference for the Treatment of Primary Hyperoxaluria.

BioDrugs 2022 Jun 22. Epub 2022 Jun 22.

Department of Urology, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294, USA.

Over the last few years, US Food and Drug Administration-approved drugs using RNA interference have come to the market. Many have treated liver-specific diseases utilizing N-acetyl galactosamine conjugation because of its effective delivery and limited off-target effects. The autosomal recessive disorder primary hyperoxaluria, specifically type 1, has benefited from these developments. Read More

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Pediatric transplantation: An international perspective.

Semin Pediatr Surg 2022 Jun 26;31(3):151192. Epub 2022 May 26.

Department of Surgery, Children's Hospital at Westmead, Children's Cancer Research Unit, Kids Research Institute, Division of Child and Adolescent Health, Sydney Medical School, University of Sydney, Westmead, NSW, Australia. Electronic address:

The international practice of transplant in the pediatric population is heterogenous. Global trends in pediatric transplant activity are increasing, with diffusion of transplant activities into developing and emerging economies. There have been impacts of the COVID-19 pandemic which have in the earlier part of the pandemic caused a decrease in the number of transplants. Read More

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Anesthetic considerations for pediatric abdominal solid organ transplantation.

Semin Pediatr Surg 2022 Jun 14;31(3):151177. Epub 2022 May 14.

Cincinnati Children's Hospital and Medical Center, 3333 Burnet Ave, MLC 2001, Cincinnati 45229-3026, Ohio.

While many pediatric patients undergo abdominal solid organ transplants every year worldwide, each is unique due to varying age, size, and comorbidities; thus, they require a careful anesthesia plan to undergo surgery safely. This article reviews the anesthetic considerations and management of patients undergoing liver and kidney transplantation. Preoperative, intraoperative, and post-operative management are discussed, including induction, access, monitoring, and maintenance. Read More

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From Haphazard to a Sustainable Normothermic Regional Perfusion Service: A Blueprint for the Introduction of Novel Perfusion Technologies.

Transpl Int 2022 3;35:10493. Epub 2022 Jun 3.

Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Normothermic Regional Perfusion (NRP) has shown encouraging clinical results. However, translation from an experimental to routine procedure poses several challenges. Herein we describe a model that led to the implementation of NRP into standard clinical practice in our centre following an iterative process of refinement incorporating training, staffing and operative techniques. Read More

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Identification and Isolation of Type II NKT Cell Subsets in Human Blood and Liver.

Front Immunol 2022 2;13:898473. Epub 2022 Jun 2.

Department of Surgery, University Hospital Regensburg, Regensburg, Germany.

Background: Steatotic livers are more prone to rejection, but are often transplanted owing to the shortage of available organs. Type II NKT (T2NKT) cells are liver-resident lymphocytes that react to lipids presented by CD1d. The role of T2NKT cells in rejection of fatty liver transplants is unclear, partly because of a lack of T2NKT cell markers and their very low frequency in blood. Read More

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The Treatment of Human Colon Xenografts Tumor in Mice with Platinum Nanosphere-5-Fluorouracil-Bovine Albumin.

J Biomed Nanotechnol 2022 Mar;18(3):778-787

Department of Oncology, Shaanxi Cancer Hospital, Xian 710061, China.

Because 5-fluorouracil (FLU) has side effects in cancer treatment, the use of FLU in therapeutic activities is limited. To overcome this challenge, the use of nano-platforms for its targeting is f great interest in biomedical fields. For this purpose, to reduce the FLU toxicity and improve the its efficacy, platinum nanospheres (PtNS) with anti-cancer properties were used. Read More

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Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?

Clin Transplant 2022 Jun 15:e14751. Epub 2022 Jun 15.

Department of Surgery, Westchester Medical Center and New York Medical College, Valhalla, New York, USA.

Introduction: Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor. Read More

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Multi-center Study of Peri-transplant Outcomes for Acute Liver Failure in Neonates Compared to Older Infants.

Transplantation 2021 Dec 16;105(12S2):S1. Epub 2021 Dec 16.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition Northwestern University Feinberg School of Medicine.

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December 2021

Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin Changes (POEMS) Syndrome and Idiopathic Portal Hypertension: A Rare Association.

Cureus 2022 May 11;14(5):e24923. Epub 2022 May 11.

Hematology, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The diagnosis of POEMS syndrome is made with three of the major criteria, two of which must include polyradiculoneuropathy and clonal plasma (PCD), and at least one of the minor criteria. The most frequent liver manifestation is hepatomegaly. Read More

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Septuagenarian Donors and Recipients in Deceased Donor Liver Transplantation: A Brazilian Single Center Experience and Literature Review.

Transplant Proc 2022 Jun 8. Epub 2022 Jun 8.

Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.

Background: The number of elderly patients who have end-stage liver disease and require liver transplantation has dramatically increased. On the other hand, liver grafts from elderly donors have been offered more frequently for transplantation. The present study aims to analyze the results of liver transplants performed with donors and recipients aged ≥70 years. Read More

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Macrophage-derived MLKL in alcohol-associated liver disease: regulation of phagocytosis.

Hepatology 2022 Jun 11. Epub 2022 Jun 11.

Northern Ohio Alcohol Center, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, United States.

Background & Aims: Mixed Lineage Kinase Domain like Pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated liver disease (ALD). While Rip3 mice are completely protected from ethanol-induced liver injury, Mlkl mice are only partially protected. Therefore, we hypothesized that cell-specific functions of MLKL may contribute to ethanol-induced injury. Read More

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Clinical Characteristics of Transplant Recipients Infected with Talaromyces Marneffei: 2 Case Reports and a Literature Review.

Infect Drug Resist 2022 3;15:2879-2890. Epub 2022 Jun 3.

Department of Respiratory and Critical Medicine, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518000, People's Republic of China.

Purpose: To summarize the clinical characteristics, treatment and outcomes of transplant recipients infected with (TM).

Materials And Methods: A retrospective analysis was performed on 2 patients with (TSM) and transplants at the First Affiliated Hospital of Guangxi Medical University, and a systematic literature review was conducted simultaneously.

Results: This article reported two patients after kidney transplantation who developed fever, cough within 3-4 months. Read More

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Primary Liver Transplantation vs. Transplant after Kasai Portoenterostomy for Infants with Biliary Atresia.

J Clin Med 2022 May 26;11(11). Epub 2022 May 26.

Division of Transplant and Advanced Hepatobiliary Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Avenue Box 57, Chicago, IL 60611, USA.

Introduction: Primary liver transplants (pLT) in patients with biliary atresia (BA) are infrequent, since most babies with BA undergo a prior Kasai portoenterostomy (KPE). This study compared transplant outcomes in children with BA with or without a prior KPE. We hypothesized that pLT have less morbidity and better outcomes compared to those done after a failed KPE. Read More

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The Effect of Pre-transplant Lipid Profile on Post-transplant Hepatocellular Carcinoma Recurrence: Retrospective Single-Center Analysis.

Turk J Gastroenterol 2022 May;33(5):434-442

Department of Surgery, Liver Transplantation Institute, İnönü University, Malatya, Turkey.

Background: Plasma lipids have been shown to relate to tumor biology. We aimed to analyze the effect of pre-transplant plasma lipid profiles on post-transplant tumor recurrence in patients with hepatocellular carcinoma and to identify any possible relationship between the pre-transplant lipid profile with maximum tumor diameter, number of tumor nodules, tumor differentiation, portal vein invasion, or serum biomarker levels.

Methods: Patients with hepatocellular carcinoma who underwent liver transplants between 2006 and 2021 had data collected pro- spectively and were analyzed retrospectively. Read More

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Pulmonary Hypertension as a Rare Complication After Orthotopic Liver Transplant in a Patient With Non-alcoholic Steatohepatitis (NASH) Cirrhosis Complicated by Hepatopulmonary Syndrome.

Cureus 2022 May 4;14(5):e24740. Epub 2022 May 4.

Internal Medicine, University of Louisville School of Medicine, Louisville, USA.

Hepatopulmonary syndrome is a phenomenon that results in an intrapulmonary shunt leading to dyspnea and hypoxemia with poor response to oxygen supplementation. It is now an indication for liver transplantation; however, some transplants result in subsequent pulmonary hypertension. Postulated mechanisms include unmasking of underlying pulmonary hypertension with liver transplant and increased pulmonary vascular resistance due to increased blood flow in hepatopulmonary syndrome. Read More

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Management of Refractory Ascites.

Florence Wong

Clin Mol Hepatol 2022 Jun 9. Epub 2022 Jun 9.

Division of Gastroenterology and Hepatology, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada.

The development of refractory ascites in approximately 10% of patients with decompensated cirrhosis heralds the progression to a more advanced stage of cirrhosis. Its pathogenesis is related to significant hemodynamic changes, initiated by portal hypertension, but ultimately leading to renal hypoperfusion and avid sodium retention. Inflammation can also contribute to the pathogenesis of refractory ascites by causing portal microthrombi, perpetuating the portal hypertension. Read More

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Evaluation of a deceased donor liver allograft from a COVID-positive donor.

Am J Transplant 2022 Jun;22(6):1721-1723

Baylor University Medical Center, Annette C. and Harold C. Simmons Transplant Institute, Dallas, Texas.

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Willingness of Kidney and Liver Transplant Candidates to Receive HCV-Infected Organs.

J Surg Res 2022 Jun 3;278:342-349. Epub 2022 Jun 3.

Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

Introduction: Transplantation of organs exposed to hepatitis C virus (HCV) into uninfected patients has yielded excellent outcomes and more widespread adoption may lead to fewer discarded organs and more transplants. Patient perceptions may shed light on acceptability and likely the uptake of HCV+/HCV- transplantation, gaps in understanding, and perceived benefits/risks.

Methods: We surveyed 435 uninfected kidney and liver transplant candidates at four centers about their attitude towards HCV-infected organs. Read More

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In-situ normothermic regional perfusion versus ex-situ normothermic machine perfusion in liver transplantation from donation after circulatory death.

Liver Transpl 2022 Jun 3. Epub 2022 Jun 3.

Department of Digestive Surgery &, Liver Transplantation Croix-Rousse Hospital, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, France.

Background: In-situ normothermic regional perfusion (NRP) and ex-situ normothermic machine perfusion (NMP) aim to improve outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD). NRP and NMP have not yet been compared directly.

Methods: In this international observational study, outcomes of LT performed between 2015 and 2019 for organs procured from cDCD donors subjected to NRP or NMP commenced at the donor centre were compared using propensity score matching (PSM). Read More

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Hepatic Venous Outflow Obstruction in Adult Deceased Donor Liver Transplantation: Classic Piggyback Implantation Versus a Modified Technique that Widens the Ostium of the Recipient's Left and Middle Hepatic Veins.

Transplant Proc 2022 Jun 2. Epub 2022 Jun 2.

Liver and Abdominal Organs Transplantation Division, Department of Gastroenterology, Clinics Hospital, University of Sao Paulo Medical School, São Paulo, Brazil; Laboratory of Medical Investigation 37, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Background: The classic piggyback technique uses the union of the 3 hepatic veins to perform the cavo-caval anastomosis. However, due to the lateral localization of the right hepatic vein, the partial clamping of the vena cava in this technique significantly reduces the venous return to the right atrium. To avoid this, we adopted in 2015 a modified piggyback technique, in which we use the common trunk of the middle and left hepatic veins and also perform a lateral incision toward the right in the anterior wall of the vena cava in order to widen the final ostium of the cavo-caval anastomosis. Read More

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Liver Ischemia and Reperfusion Induce Periportal Expression of Necroptosis Executor pMLKL Which Is Associated With Early Allograft Dysfunction After Transplantation.

Front Immunol 2022 17;13:890353. Epub 2022 May 17.

Department of Surgery, Erasmus MC Transplant Institute, University Medical Center, Rotterdam, Netherlands.

Background: Early allograft dysfunction (EAD) following liver transplantation (LT) remains a major threat to the survival of liver grafts and recipients. In animal models, it is shown that hepatic ischemia-reperfusion injury (IRI) triggers phosphorylation of Mixed Lineage Kinase domain-like protein (pMLKL) inducing necroptotic cell death. However, the clinical implication of pMLKL-mediated cell death in human hepatic IRI remains largely unexplored. Read More

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Transplant Trial Watch.

Transpl Int 2022 16;35:10513. Epub 2022 May 16.

University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.

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A Case of Tacrolimus Maculopathy.

Clin Pract 2022 May 1;12(3):276-283. Epub 2022 May 1.

Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.

(1) Background: Tacrolimus is an immunosuppressive agent commonly used in the management of solid organ allogeneic transplants in the prevention of rejection. Serious ophthalmic adverse effects with Tacrolimus have been reported in the literature, which includes cortical blindness and optic neuropathy. (2) Methods: We describe a rare case of maculopathy as a possible complication of Tacrolimus therapy. Read More

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Preemptive simultaneous pancreas-kidney transplantation has survival benefit to patients.

Kidney Int 2022 May 27. Epub 2022 May 27.

Nephrology and Kidney Transplant Department, Hospital Clínic de Barcelona, Barcelona, Spain; Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Fundació Clínic per a la Recerca Biomèdica (FCRB), Barcelona, Spain. Electronic address:

Several organ allocation protocols give priority to wait-listed simultaneous kidney-pancreas (SPK) transplant recipients to mitigate the higher cardiovascular risk of patients with diabetes mellitus on dialysis. The available information regarding the impact of preemptive simultaneous kidney-pancreas transplantation on recipient and graft outcomes is nonetheless controversial. To help resolve this, we explored the influence of preemptive simultaneous kidney-pancreas transplants on patient and graft survival through a retrospective analysis of the OPTN/UNOS database, encompassing 9690 simultaneous transplant recipients between 2000 and 2017. Read More

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