48,168 results match your criteria Transplantation Lung


Vaccination coverage of recommended vaccines and determinants of vaccination in at-risk groups.

Hum Vaccin Immunother 2020 Jul 2:1-8. Epub 2020 Jul 2.

Leuven University Vaccinology Center , Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Upon exposure to vaccine-preventable diseases, certain individuals are at increased risk for complications due to preexisting diseases, age or immunosuppressive treatment. Vaccination against influenza, pneumococcal disease and hepatitis B (for some groups) is advised in addition to standard vaccination against diphtheria, tetanus and pertussis. We estimated the vaccination coverage and determinants of recommended vaccinations in patients with diabetes mellitus type 1 (n = 173) and type 2 (n = 177), chronic kidney disease (CKD) (n = 138), heart failure (n = 200), chronic obstructive pulmonary disease (COPD) (n = 187), HIV (n = 201) or solid organ transplantation (SOT) (n = 201) in a monocentric study. Read More

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http://dx.doi.org/10.1080/21645515.2020.1763739DOI Listing

Krebs von den Lungen-6 as biomarker for disease severity assessment in interstitial lung disease: a comprehensive review.

Biomark Med 2020 Jul 2. Epub 2020 Jul 2.

Respiratory Diseases & Lung Transplantation, Department of Medical & Surgical Sciences & Neurosciences, Siena University Hospital, Siena, Italy.

Interstitial lung diseases (ILD) are a group of lung disorders characterized by interstitial lung thickening. Krebs von den Lungen-6 (KL-6) is a molecule that is predominantly expressed by damaged alveolar type II cells and it has been proposed as a potential biomarker of different ILD. A growing literature about KL-6 has been reviewed and selected to evaluate its role in the clinical management of ILD to predict disease diagnosis, activity, prognosis and treatment response. Read More

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http://dx.doi.org/10.2217/bmm-2019-0545DOI Listing

Cytomegalovirus infection as an underestimated trigger for checkpoint inhibitor-related pneumonitis in lung cancer: a retrospective study.

Clin Transl Oncol 2020 Jul 1. Epub 2020 Jul 1.

State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital, Guangzhou Medical University, 151# Yanjiang Road, Guangzhou, 510120, China.

Objectives: Checkpoint inhibitor-related pneumonitis (CIP) is a rare but potentially fatal complication of immune checkpoint inhibitors (ICIs). At present, the mechanism of CIP is not completely clear. Cytomegalovirus (CMV) infection is widespread in the population. Read More

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http://dx.doi.org/10.1007/s12094-020-02432-5DOI Listing

Cardiac safe hematopoietic stem cell transplantation for systemic sclerosis with poor cardiac function: a pilot safety study that decreases neutropenic interval to 5 days.

Bone Marrow Transplant 2020 Jul 1. Epub 2020 Jul 1.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

We compared three fludarabine-based regimens for systemic sclerosis patients with a high-risk cardiac phenotype that according to EBMT criteria would be a contraindication for a high-dose cyclophosphamide (200 mg/kg) transplant regimen. All three regimens included fludarabine, ATG, and cyclophosphamide (60 mg/kg), while two regimens also included rituximab with or without IVIG. Treatment related mortality (TRM) was 2. Read More

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http://dx.doi.org/10.1038/s41409-020-0978-2DOI Listing

Toothpick Aspiration Induces Massive Hemoptysis: a Case Report.

Tanaffos 2019 Apr;18(4):369-372

Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Massive hemoptysis refers to bleeding from the sputum exceeding 100 ml/day. This condition is known to have a poor prognosis. Although foreign body aspiration is not as common as other risk factors, it may result in massive hemoptysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309886PMC

Thymoma Recurrence and its Predisposing Factors in Iranian Population: a Single Center Study.

Tanaffos 2019 Apr;18(4):355-364

Lung Transplantation Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Thymoma is relatively rare tumor. Prognosis and patients' outcome vary across different studies. We aimed to study the predisposing factors causing tumor recurrence in thymoma patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309889PMC

Evaluation of the Effects of E-Learning on Nurses' Behavior and Knowledge Regarding Venous Thromboembolism.

Tanaffos 2019 Apr;18(4):338-345

Chronic Respiratory Diseases Research center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Continuing medical education (CME) is an integral part of nursing professionalization, which can be effective in the development of nursing behavior. E-learning can play an important role in CME programs. This study aimed to evaluate the effectiveness of an E-learning program in increasing the nurses' knowledge and behavior regarding care for venous thromboembolism (VTE) patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309888PMC

Outcomes and Complications of Bronchial Angioembolization in Patients with Massive Hemoptysis.

Tanaffos 2019 Apr;18(4):310-314

Lung Transplantation Research Center, Department of Cardiology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Massive hemoptysis is a potentially life threatening medical condition and one major problem for both patients and physicians. Choosing the appropriate treatment for the patients is crucial in order to decrease the complications and increase the success rate. Hence, in this study the outcomes and complications of bronchial angioembolization (BAE) were determined in patients with massive hemoptysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309885PMC

Enhancing Care for Individuals with Advanced Cystic Fibrosis Lung Disease.

Pediatr Pulmonol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pediatrics, Division of Pulmonology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

While remarkable advances in cystic fibrosis (CF) care have led to improvements in survival and quality of life, many individuals with CF are living with advanced cystic fibrosis lung disease (ACFLD) and others will face continued disease progression and its associated complex treatments and choices. This review will provide a summary of recently published guidelines for ACFLD care and lung transplant referral and highlight ongoing work to enhance care of those with ACFLD through improvements in medical and psychosocial care, palliative care, and care around lung transplantation. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/ppul.24937DOI Listing

Intracerebral abscess due to Cutibacterium acnes after lung transplantation.

Transpl Infect Dis 2020 Jul 1:e13398. Epub 2020 Jul 1.

University Hospital Gasthuisberg, Dept. Respiratory Disease, UZ Leuven, Leuven, Belgium.

Cutibacterium (C.) acnes, a Gram-positive bacterium that is part of the commensal flora, is increasingly noticed as an opportunistic pathogen in serious infections in both immunocompromised and immunocompetent patients. The indolent character and often difficult identification because of its slow growth contribute to delayed diagnosis or underdiagnosis. Read More

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http://dx.doi.org/10.1111/tid.13398DOI Listing

Panel-Reactive and Donor-Specific Antibodies before Lung Transplantation can Affect Outcomes in Korean Patients Receiving Lung Transplantation.

Yonsei Med J 2020 Jul;61(7):606-613

Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Data on the distribution and impact of panel reactive antibodies (PRA) and donor specific antibodies (DSA) before lung transplantation in Asia, especially multi-center-based data, are limited. This study evaluated the prevalence of and effects of PRA and DSA levels before lung transplantations on outcomes in Korean patients using nationwide multicenter registry data.

Materials And Methods: This study included 103 patients who received a lung transplant at five tertiary hospitals in South Korea between March 2015 and December 2017. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.7.606DOI Listing

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore.

Transplant Direct 2020 Jun 8;6(6):e554. Epub 2020 May 8.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Read More

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http://dx.doi.org/10.1097/TXD.0000000000001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363PMC

Ultrasound-guided double central venous access for azygos vein via the ninth and tenth intercostal veins.

J Vasc Access 2020 Jun 30:1129729820937133. Epub 2020 Jun 30.

Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.

Some patients with intestinal failure, who are dependent on total parenteral nutrition for long periods, suffer from a lack of suitable conventional venous access points, including axillary, external jugular, internal jugular, subclavian, saphenous, and the brachio-cephalic and femoral veins, due to their occlusion. Furthermore, extensive central venous stenosis and/or thrombosis of the superior and inferior vena cava may preclude further catheterization, so uncommon routes must be used, which can be challenging. In such patients, the azygos vein via the intercostal vein is a viable candidate. Read More

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http://dx.doi.org/10.1177/1129729820937133DOI Listing

Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations.

Int J Pharm 2020 Jun 27:119490. Epub 2020 Jun 27.

The University of Texas at Austin, College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, Austin, TX, USA.

We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can increase drug loading up to 95% while maintaining good aerosol performance. Drug loading affected the specific surface area and moisture sorption of TFF formulations, but it did not affect the chemical stability, physical stability, and dissolution of tacrolimus. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119490DOI Listing

Vitamin D modulates E-cadherin turnover by regulating TGF-β and Wnt signalings during EMT-mediated myofibroblast differentiation in A459 cells.

J Steroid Biochem Mol Biol 2020 Jun 27:105723. Epub 2020 Jun 27.

Lung Transplantation Center, Department of Thoracic Surgery, Kartal Kosuyolu High Speciality Educational and Research Hospital, Kartal, Istanbul, Turkey. Electronic address:

Vitamin D (VitD) has an anti-fibrotic effect on fibrotic lungs. It reduces epithelial-mesenchymal transition (EMT) on tumors. We aimed to investigate target proteins of VitD for the regression of EMT-mediated myofibroblast differentiation. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105723DOI Listing

Transforming Diagnostics in Lung Transplantation: From Bronchoscopy to an A.I.-driven Approach.

Am J Respir Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

Temple University, 6558, Cardiovascular Surgery, Philadelphia, Pennsylvania, United States;

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http://dx.doi.org/10.1164/rccm.202005-1821EDDOI Listing

Lung perfusion scintigraphy to detect chronic lung allograft dysfunction after living-donor lobar lung transplantation.

Sci Rep 2020 Jun 29;10(1):10595. Epub 2020 Jun 29.

Department of General Thoracic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-City, Okayama, 700-8558, Japan.

Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. Read More

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http://dx.doi.org/10.1038/s41598-020-67433-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324574PMC

Ulcerated nodule in a 50-year old man who underwent lung transplantation.

CMAJ 2020 Jun;192(26):E715

Division of Dermatology (Lemieux), Department of Medicine; Department of Pathology (Belisle) and Division of Infectious Diseases (Luong), Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Que.

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http://dx.doi.org/10.1503/cmaj.191540DOI Listing

Bariatric surgery to achieve transplant in end-stage organ disease patients: A systematic review and meta-analysis.

Am J Surg 2020 Jun 13. Epub 2020 Jun 13.

University of Alabama at Birmingham Schools of Medicine, Department of Surgery, United States.

Background: As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing.

Methods: We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.04.041DOI Listing

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol.

BMC Nephrol 2020 Jun 29;21(1):242. Epub 2020 Jun 29.

Department of Imaging, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal decline on top of routinely available data, particularly in the early stages. Read More

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http://dx.doi.org/10.1186/s12882-020-01901-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323369PMC

Immunosuppressive therapy in lung transplantation.

Curr Pharm Des 2020 Jun 27. Epub 2020 Jun 27.

Surgery, University of Toronto, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, 200 Elizabeth St 9N969, Toronto ON M5G2C4. Canada.

Long term survival and quality of life after lung transplantation are still affected by the development of chronic lung graft dysfunction (CLAD). CLAD is the number one cause of death one year after transplant; and there is no effective therapy available to date. Transplant centers' approaches include perioperative immunosuppression, maintenance immunosuppression, and the treatment of eventual rejection. Read More

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http://dx.doi.org/10.2174/1381612826666200628023150DOI Listing

Acute Kidney Injury in Patients Undergoing Cardiopulmonary Bypass for Lung Transplantation.

J Surg Res 2020 Jun 26;255:332-338. Epub 2020 Jun 26.

Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Cardiopulmonary bypass (CPB) is often used to support patients undergoing lung transplantation who are intolerant of anatomic manipulation or single lung ventilation during the procedure. However, CPB may be associated with adverse outcomes. We evaluated the hypothesis that CPB is associated with increased acute kidney injury (AKI) and postoperative mortality after lung transplantation. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.072DOI Listing

A multicenter trial of a shared DECision Support Intervention for Patients offered implantable Cardioverter-DEfibrillators: DECIDE-ICD rationale, design, Medicare changes, and pilot data.

Am Heart J 2020 Apr 20;226:161-173. Epub 2020 Apr 20.

Adult and Child Consortium for Outcomes Research and Delivery Science, Aurora, CO; VA Eastern Colorado Geriatric Research Education and Clinical Center, Denver, CO; Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.

Shared decision making (SDM) facilitates delivery of medical therapies that are in alignment with patients' goals and values. Medicare national coverage decision for several interventions now includes SDM mandates, but few have been evaluated in nationwide studies. Based upon a detailed needs assessment with diverse stakeholders, we developed pamphlet and video patient decision aids (PtDAs) for implantable cardioverter/defibrillator (ICD) implantation, ICD replacement, and cardiac resynchronization therapy with defibrillation to help patients contemplate, forecast, and deliberate their options. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.010DOI Listing

Chronic rhinosinusitis in patients with cystic fibrosis-Current management and new treatments.

Laryngoscope Investig Otolaryngol 2020 Jun 13;5(3):368-374. Epub 2020 Jun 13.

Department of Otorhinolaryngology Mayo Clinic Rochester Minnesota USA.

Objectives: The purpose of this article is to provide a state-of-the-art review of the literature and summarize the latest publications on medical and surgical treatment of cystic fibrosis (CF) chronic rhinosinusitis (CRS), with an emphasis on describing recent advancements in cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies.

Methods: A comprehensive literature review was conducted utilizing the PubMed database with search phrases detailed within the body of the article. Abstracts were reviewed to include publications detailing medical, surgical, and CFTR modulating therapies for CF CRS. Read More

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http://dx.doi.org/10.1002/lio2.401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314487PMC

First Case of Brucella Pneumonia in a Lung Transplant Patient: Case Report and Review of the Literature.

Cureus 2020 Jun 21;12(6):e8733. Epub 2020 Jun 21.

Organ Transplant, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.

Brucella is one of the most common zoonotic diseases worldwide. It is endemic in the Mediterranean basin. Brucella pneumonia is a rare complication of brucellosis that can present with a variety of clinical and radiological manifestations. Read More

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http://dx.doi.org/10.7759/cureus.8733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308817PMC

Outcome of Extracorporeal Photopheresis as an Add-On Therapy for Antibody-Mediated Rejection in Lung Transplant Recipients.

Transfus Med Hemother 2020 Jun 5;47(3):205-213. Epub 2020 May 5.

Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Introduction: The diagnosis and treatment of antibody-mediated rejection (AMR) after lung transplantation has recently gained recognition within the transplant community. Extracorporeal photopheresis (ECP), currently used to treat chronic lung allograft dysfunction, modulates various pathways of the immune system known to be involved in AMR. We hypothesize that adding ECP to established AMR treatments could prevent the rebound of donor-specific antibodies (DSA). Read More

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http://dx.doi.org/10.1159/000508170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315205PMC

Comparison of Vancomycin Pharmacokinetics in Cystic Fibrosis Patients Pre and Post-lung Transplant.

Clin Med Insights Circ Respir Pulm Med 2020 15;14:1179548420930925. Epub 2020 Jun 15.

Pharmacy Department, Boston Children's Hospital, Boston, MA, USA.

Background: Vancomycin is commonly used to treat acute cystic fibrosis (CF) exacerbations associated with methicillin-resistant (MRSA). Multiple studies have demonstrated pharmacokinetic differences of antimicrobials in the CF population. Very little data exist regarding pharmacokinetics postlung transplant, but 2 studies have noted changes in tobramycin pharmacokinetics. Read More

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http://dx.doi.org/10.1177/1179548420930925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297476PMC

HERBALIFE® ASSOCIATED SEVERE HEPATOTOXICITY IN A PREVIOUSLY HEALTHY WOMAN.

Acta Clin Croat 2019 Dec;58(4):771-776

1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Department of Gastroenterology and Hepatology, Sveti Duh University Hospital, Zagreb, Croatia; 3Faculty of Health Studies, University of Rijeka, Rijeka, Croatia; 4Department of Endocrinology, Diabetes and Metabolic Diseases, Sveti Duh University Hospital, Zagreb, Croatia; 5Jordanovac Hospital for Lung Diseases, Zagreb University Hospital Centre, Zagreb, Croatia.

Lately there has been an increased consumption of herbal preparations, distributed as nutritional supplements, often claimed to be 'natural' and harmless. However, as their use is not subjected to strict pre-marketing testing and regulations, their ingredients are not clearly defined and there is no quality control or proof of their effectiveness and safety. A growing body of references accentuate their harmful effects, in particular hepatotoxicity, which varies from minimal hepatogram changes to fulminant hepatitis requiring liver transplantation. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314303PMC
December 2019

Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - Lung axis hypothesis.

Med Hypotheses 2020 Jun 23;144:110023. Epub 2020 Jun 23.

Department of Gastroenterology, IBD and Nutritional Support, CHU Paris Nord-Val de Seine, Beaujon Hospital, Clichy, France.

Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors. As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection. SARS-CoV2 presents the ability to infect epithelial cells of the respiratory tract as well as the intestinal tract. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.110023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308746PMC

Immune modulation via T regulatory cell enhancement: disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases - An EAACI position paper of the Task Force on Immunopharmacology (TIPCO).

Allergy 2020 Jun 27. Epub 2020 Jun 27.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Therapeutic advances using targeted biologicals and small molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen immunotherapy for selected allergic diseases, fail to change the disease course. Read More

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http://dx.doi.org/10.1111/all.14478DOI Listing

Comparison of reduced-toxicity conditioning protocols using fludarabine, melphalan combined with thiotepa or carmustine in allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2020 Jun 26. Epub 2020 Jun 26.

Department of Hematology/Oncology/Stem Cell Transplantation, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

The age of patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) has increased during the last decades, mainly due to improved reduced-intensity/toxicity conditioning protocols. A reduced-intensity conditioning based on fludarabin, carmustin/BCNU and melphalan (FBM) has been previously developed at our institution. Since we observed detrimental effects in individual patients with compromised lung function, efforts have been made in order to replace BCNU by thiotepa (FTM) to reduce toxicity. Read More

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http://dx.doi.org/10.1038/s41409-020-0986-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319212PMC

Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.

Redox Biol 2020 Jun 17:101609. Epub 2020 Jun 17.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209, USA. Electronic address:

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation and lipid metabolism through the modulation of oxidative stress pathways by TTP target genes. In a BM transplantation study, lethally irradiated atherogenic LDLR mice were reconstituted with BM cells from either wild type (TTP) or TTP knockout (TTP) mice, and fed a Western diet for 12 weeks. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101609DOI Listing

Study design of the DAS-OLT trial: a randomized controlled trial to evaluate the impact of dexmedetomidine on early allograft dysfunction following liver transplantation.

Trials 2020 Jun 26;21(1):582. Epub 2020 Jun 26.

Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.

Background: Perioperative ischemia/reperfusion (I/R) injury during liver transplantation is strongly associated with early allograft dysfunction (EAD), graft loss, and mortality. Hepatic I/R injury also causes remote damage to other organs including the renal and pulmonary systems. Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist which is used as an adjuvant to general anesthesia, has been shown in preclinical studies to provide organ protection by ameliorating the effects of I/R injury in a range of tissues (including the liver). Read More

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http://dx.doi.org/10.1186/s13063-020-04497-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317895PMC

Primary pulmonary extranodal natural killer/T-cell lymphoma (ENKTL), nasal type: Two case reports and literature review.

Medicine (Baltimore) 2020 Jun;99(26):e20822

Department of Cardio-Thoracic Surgery, Shenzhen University General Hospital.

Introduction: Extranodal natural killer/T-cell lymphoma (ENKTL) - nasal type is an aggressive form of malignant non-Hodgkin lymphoma with a very poor prognosis. Especially primary pulmonary ENKTL is a relatively rare form of non-Hodgkin lymphoma. Until now, the prevalence of primary pulmonary ENKTL is unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000020822DOI Listing

Human Lungs Airway Epithelium Upregulate MicroRNA-17 and MicroRNA-548b in Response to Cold Ischemia and Ex Vivo Reperfusion.

Transplantation 2020 Jun 23. Epub 2020 Jun 23.

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Lung ischemia-reperfusion injury (IRI) after transplantation is associated with worse clinical outcomes. MicroRNA (miR) are critical regulators of gene expression that could provide potential targets for novel gene therapy. Herein, we aim to examine the feasibility of using the ex vivo lung perfusion (EVLP) platform to examine the changes in miR expression in human lungs in response to cold ischemia and ex vivo reperfusion (CI/EVR). Read More

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http://dx.doi.org/10.1097/TP.0000000000003370DOI Listing

Attenuated early inflammatory response in solid organ recipients with COVID-19.

Clin Transplant 2020 Jun 26:e14027. Epub 2020 Jun 26.

Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.

Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. The specific features of coronavirus disease 2019 (COVID-19) in immunosuppressed patients are largely unknown and therapeutic experience is lacking. Seven transplanted patients (two liver, three kidneys, one double lung, one heart) admitted to the Ludwig-Maximilians-University Munich because of COVID-19 and tested positive for SARS-CoV-2 were included. Read More

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http://dx.doi.org/10.1111/ctr.14027DOI Listing

Does lobar or size-reduced lung transplantation offer satisfactory early and late outcomes?

Interact Cardiovasc Thorac Surg 2020 Jul;31(1):93-97

Service de Chirurgie Thoracique, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

A best evidence topic was constructed according to a structured protocol. The question addressed was whether size-reduced or lobar lung transplantation (LLTx) offers the same benefit as classic lung transplantation (LTx). Of the 147 papers found using the reported search, 9 were selected to provide the best evidence. Read More

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http://dx.doi.org/10.1093/icvts/ivaa051DOI Listing

Chronic pain 1-5 years after heart transplantation-A nationwide cross-sectional cohort study.

Nurs Open 2020 Jul 27;7(4):1146-1156. Epub 2020 Apr 27.

Institute of Health Sciences Lund University Lund Sweden.

Aim: To provide a multidimensional assessment of self-reported chronic pain 1-5 years after heart transplantation and its relationship with self-reported well-being, fatigue, recovery, self-efficacy and socio-economic factors and to explore differences between heart recipients and a cohort of lung recipients.

Design: This multicentre, cross-sectional, cohort study is a part of the Swedish national Self-management after thoracic transplantation study.

Methods: Six questionnaires were distributed at the heart recipients yearly follow-up (1-5 years) at three Swedish university hospitals 2014-2017. Read More

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http://dx.doi.org/10.1002/nop2.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308699PMC

CCL1 blockade alleviates human mesenchymal stem cell (hMSC)-induced pulmonary fibrosis in a murine sclerodermatous graft-versus-host disease (Scl-GVHD) model.

Stem Cell Res Ther 2020 Jun 26;11(1):254. Epub 2020 Jun 26.

Hematology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpodae-ro, Seocho-gu, Seoul, 06591, South Korea.

Background: Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this study, bone marrow- or adipose tissue-derived human mesenchymal stem cells (hMSCs) were injected into the Scl-GVHD mice to address their therapeutic effect on CGVHD. Read More

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http://dx.doi.org/10.1186/s13287-020-01768-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318460PMC

Management and Outcomes of Diverticulitis After Lung Transplantation.

Prog Transplant 2020 Jun 25:1526924820933830. Epub 2020 Jun 25.

Norton Thoracic Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Introduction: Most lung transplant patients are older than 50 years. Complications from colonic diverticula are not uncommon, especially with chronic immunosuppression. However, limited data exist regarding the optimal management of these patients. Read More

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http://dx.doi.org/10.1177/1526924820933830DOI Listing

Therapeutic plasma exchange in acute on chronic liver failure.

J Clin Apher 2020 Jun 24. Epub 2020 Jun 24.

Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

Background: Acute on chronic liver failure (ACLF) has been identified as a distinct syndrome due to acute decompensation of liver cirrhosis accompanied by extra-hepatic organ failure, primarily caused by an overwhelming systemic immune response. Therapeutic plasma exchange (TPE) has been demonstrated in a randomized controlled trial to improve transplant free survival in acute liver failure. Here we investigated if TPE might have comparable beneficial effects in patients with ACLF. Read More

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http://dx.doi.org/10.1002/jca.21799DOI Listing

Roles of Wnt/β-Catenin Signaling Pathway Regulatory Long Non-Coding RNAs in the Pathogenesis of Non-Small Cell Lung Cancer.

Cancer Manag Res 2020 3;12:4181-4191. Epub 2020 Jun 3.

Central Laboratory, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Lung cancer is one of the leading causes of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. Long non-coding RNAs (lncRNAs) are promising novel diagnostic and prognostic biomarkers, as well as potential therapeutic targets for lung cancer. Read More

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http://dx.doi.org/10.2147/CMAR.S241519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280066PMC

Current trends in thoracic surgery.

Nagoya J Med Sci 2020 May;82(2):161-174

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Thoracic surgery has evolved drastically in recent years. Although thoracic surgeons mainly deal with tumorous lesion in the lungs, mediastinum, and pleura, they also perform lung transplantation surgery in patients with end-stage lung disease. Herein, we introduce various major current topics in thoracic surgery. Read More

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http://dx.doi.org/10.18999/nagjms.82.2.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276403PMC

Author Correction: Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis.

Nat Immunol 2020 Jun 24. Epub 2020 Jun 24.

Université de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41590-020-0739-9DOI Listing

Noninfectious pulmonary complications of haematopoietic stem cell transplantation.

Eur Respir Rev 2020 Jun 23;29(156). Epub 2020 Jun 23.

Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA

Haematopoietic stem cell transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. Pulmonary complications, both infectious and noninfectious, are a major cause of morbidity and mortality in patients who undergo HSCT. Recent advances in prophylaxis and treatment of infectious complications has increased the significance of noninfectious pulmonary conditions. Read More

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http://dx.doi.org/10.1183/16000617.0119-2019DOI Listing

Single running suture technique is associated with low rate of bronchial complications after lung transplantation.

J Thorac Cardiovasc Surg 2020 Feb 19. Epub 2020 Feb 19.

Division of Thoracic Surgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: Lung transplantation has evolved to a routinely performed surgical procedure in patients with end-stage pulmonary disease. Bronchial healing problems are rare but represent a potential life-threatening complication. Herein, we aimed to define the incidence, classification, and treatment of bronchial complications after lung transplantation. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.12.119DOI Listing
February 2020

Pediatric lung transplantation: Dynamics of the microbiome and bronchiolitis obliterans in cystic fibrosis.

J Heart Lung Transplant 2020 May 19. Epub 2020 May 19.

Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois; Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois; Department of Surgery, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

Background: Compositional changes in the microbiome are associated with the development of bronchiolitis obliterans (BO) after lung transplantation (LTx) in adults with cystic fibrosis (CF). The association between the lower airway bacterial community and BO after LTx in children with CF remains largely unexplored and is possibly influenced by frequent antibiotic therapy. The objectives of this study were to examine the relationship between bacterial community dynamics and the development of BO and analyze antibiotic resistance trends in children after LTx for CF. Read More

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http://dx.doi.org/10.1016/j.healun.2020.04.016DOI Listing
May 2020
6.650 Impact Factor

Afterlife for lungs: A way to increase donor lungs for transplant.

Am J Transplant 2020 Jun 24. Epub 2020 Jun 24.

Lung Banks of America, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1111/ajt.16068DOI Listing

Statin intensity and risk for cardiovascular events after heart transplantation.

ESC Heart Fail 2020 Jun 24. Epub 2020 Jun 24.

Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.

Aims: Statins improve survival and reduce rejection and cardiac allograft vasculopathy after heart transplantation (HT). The impact of different statin intensities on clinical outcomes has never been assessed. We set out to determine the impact of statin exposure on cardiovascular outcomes after HT. Read More

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http://dx.doi.org/10.1002/ehf2.12784DOI Listing

Coping Patterns and Emotional Distress in Patients With Chronic Obstructive Lung Disease Who Are Undergoing Lung Transplant Evaluation.

Prog Transplant 2020 Jun 24:1526924820933817. Epub 2020 Jun 24.

Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Norway.

Objectives: Living with severe lung disease like chronic obstructive pulmonary disease (COPD) is a very stressful situation. The way patients cope may impact their symptoms of anxiety and depression and physical function as well. We studied how ways of coping are associated with levels of emotional distress and lung function in patients with COPD being evaluated for lung transplantation. Read More

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http://dx.doi.org/10.1177/1526924820933817DOI Listing