45,238 results match your criteria Transplantation Lung


Post-reperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Acute kidney injury (AKI) is common after lung transplantation, but molecular markers remain poorly studied. The endothelial activation markers soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are implicated in kidney microcirculatory injury in animal models of AKI. We tested the association of 6-hour post-reperfusion plasma levels of these markers with post-transplant AKI severity in patients enrolled in the Lung Transplant Outcomes Group prospective cohort study at the University of Pennsylvania during two eras: 2004-06 (n=61) and 2013-15 (n=67). Read More

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http://dx.doi.org/10.1111/ajt.15402DOI Listing

Successful Lung Transplantation in a Patient with Chronic Granulomatous Disease.

J Clin Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s10875-019-00623-6DOI Listing

Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstitial Lung Disease: A Retrospective Study.

Can Respir J 2019 20;2019:5315903. Epub 2019 Mar 20.

Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa 920-8641, Japan.

Background: Standard chemotherapy for advanced non-small-cell lung cancer (NSCLC) with preexisting interstitial lung disease (ILD) has not yet been established. Although a combination of carboplatin and paclitaxel is most frequently used for patients with advanced NSCLC and ILD, the safety and efficacy of carboplatin plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) are yet to be elucidated.

Objectives: This study aimed to evaluate the safety and efficacy of carboplatin plus nab-paclitaxel for advanced NSCLC with ILD. Read More

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http://dx.doi.org/10.1155/2019/5315903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446117PMC

Fatal diffuse pulmonary fat microemboli following reperfusion in liver transplantation with the use of marginal steatotic allografts.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Phoenix, Arizona.

Organ shortage is a major cause of delayed liver transplantation and increased wait list time. The level of donor steatosis is a significant determinant in organ selection. Scarcity of organs has led some programs to expand their acceptable criteria for the percentage of steatosis. Read More

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http://dx.doi.org/10.1111/ajt.15399DOI Listing

Successful lung donation at the age of 6 weeks: Challenges and lessons learned.

Pediatr Transplant 2019 Apr 23:e13419. Epub 2019 Apr 23.

Royal Papworth Hospital, Cambridge, UK.

A clinical case of successful procurement and transplantation of bilateral lungs from 6-week-old infant with sepsis secondary to bacterial meningitis is reported. Forty-one-day-old male infant (height 60 cm, weight 4 kg) died of cerebral edema secondary to Escherichia coli meningitis and bacteremia. Preretrieval assessment included the following: arterial gases; pO 50. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13419
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http://dx.doi.org/10.1111/petr.13419DOI Listing
April 2019
1 Read

[Therapeutic options for oligoprogressive non-small cell lung cancer].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Département d'oncologie radiothérapie, institut d'oncologie thoracique (IOT), Gustave-Roussy, université Paris-Saclay, 114, rue Vaillant, 94805 Villejuif, France; Université Paris Sud, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France; Inserm U1030, radiothérapie moléculaire, 94805 Villejuif, France. Electronic address:

Lung cancer is the leading cause of cancer-related mortality and more than half of the cases are diagnosed at a metastatic stage. Major progress in terms of systemic treatments has been achieved in recent decades. Access to new anti-PD-(L) 1 immunotherapies and targeted therapies for non-small cell lung cancer (NSCLC) with oncogenic addiction such as EGFR mutation or ALK rearrangement have led to improved outcomes. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.04.011DOI Listing
April 2019
1 Read

Antibodies against Angiotensin II Type 1 and Endothelin A Receptors: Relevance and pathogenicity.

Hum Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Antibodies against two G-protein coupled receptors (GPCRs), angiotensin II type 1 receptor (AT1R) and endothelin A receptor (ETAR) are among a growing number of autoantibodies that are found to be associated with allograft dysfunction. AT1R antibodies (AT1Rabs) and ETAR antibodies (ETARabs) have been shown to activate their target receptors and affect signaling pathways. Multiple single center reports have shown an association between presence of these antibodies and acute or chronic rejection and graft loss in kidney, heart, liver, lung and composite tissue transplantations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859193013
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http://dx.doi.org/10.1016/j.humimm.2019.04.012DOI Listing
April 2019
1 Read

Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619840375

1 MedStar Washington Hospital Center, Washington, DC, USA.

Pulmonary veno-occlusive disease (PVOD) is a rare entity that is usually mistaken with pulmonary arterial hypertension (PAH) but is considered class I' of PAH. It is important to subclassify PVOD and distinguish it from PAH as treatment with vasodilators in PVOD patients is controversial and may be fatal. In this article, we describe a case of PVOD and how we diagnosed it. Read More

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http://dx.doi.org/10.1177/2324709619840375DOI Listing

Improved Mortality Associated with the Use of Extracorporeal Membrane Oxygenation.

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

Cardiothoracic Surgery, University of Colorado Denver, Aurora, CO, United States.

Background: Our objective was to evaluate the association of bridge to transplant (BTT) extracorporeal membrane oxygenation (ECMO) on survival after lung transplantation (LTx) and determine the degree to which transplant center volume affects this relationship.

Methods: Using the United Network for Organ Sharing database, we performed a retrospective cohort study evaluating the survival of patients undergoing LTx between 2005 and 2017. Based on previous literature, LTx centers were classified into 3 groups using their average annual LTx volume over the preceding 5 years; <25, 25-49, and >50. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193056
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.057DOI Listing
April 2019
1 Read

Balancing the risk and rewards of utilizing organs from hepatitis C viremic donors.

Curr Opin Organ Transplant 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Liver Center, Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Owing to long waitlist times and high waitlist morbidity and mortality, strategies to increase utilization of hepatitis C viremic-deceased donor organs are under investigation in kidney, liver, heart, and lung transplantation.

Recent Findings: Direct-acting antiviral medications for hepatitis C virus infection have high cure rates and are well tolerated. Small, single-center trials in kidney and heart transplant recipients have demonstrated that with early posttransplant direct-acting antiviral therapy, 100% of uninfected recipients of hepatitis C viremic organs have been cured of infection after transplantation. Read More

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http://Insights.ovid.com/crossref?an=00075200-900000000-9903
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http://dx.doi.org/10.1097/MOT.0000000000000651DOI Listing
April 2019
1 Read

Variant Classification in Precision Oncology.

Int J Cancer 2019 Apr 22. Epub 2019 Apr 22.

Institute of Pathology, University Hospital Heidelberg, Germany.

Next-generation sequencing has become a cornerstone of therapy guidance in cancer precision medicine and an indispensable research tool in translational oncology. Its rapidly increasing use during the last decade has expanded the options for targeted tumor therapies, and molecular tumor boards have grown accordingly. However, with increasing detection of genetic alterations, their interpretation has become more complex and error-prone, potentially introducing biases and reducing benefits in clinical practice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32358
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http://dx.doi.org/10.1002/ijc.32358DOI Listing
April 2019
3 Reads

[Selection of lung transplant candidates in France in 2019].

Rev Mal Respir 2019 Apr 18. Epub 2019 Apr 18.

Pôle thorax et vaisseaux, clinique universitaire de pneumologie, CHU de Grenoble-Alpes, 38000 Grenoble, France; Université Grenoble-Alpes, 38000 Grenoble, France. Electronic address:

Introduction: In 2015, the International Society for Heart and Lung Transplantation (ISHLT) published a consensus document for the selection of lung transplant candidates. In the absence of recent French recommendations, this guideline is useful in order to send lung transplant candidates to the transplantation centers and to list them for lung transplantation at the right time.

Background: The main indications for lung transplantation in adults are COPD and emphysema, idiopathic pulmonary fibrosis and interstitial diseases, cystic fibrosis and pulmonary arterial hypertension (PAH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07618425193007
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http://dx.doi.org/10.1016/j.rmr.2018.03.009DOI Listing
April 2019
1 Read

Risk factors for death or heart transplantation in single-ventricle physiology (tricuspid atresia, pulmonary atresia, and heterotaxy): A systematic review and meta-analysis.

J Heart Lung Transplant 2019 Apr 4. Epub 2019 Apr 4.

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: In this study we sought to evaluate risk factors (RFs) for death or heart transplantation (D-HT) in single-ventricle (SV) physiology due to tricuspid atresia (TA), pulmonary atresia‒intact ventricular septum (PA-IVS), and heterotaxy with SV (HX), clinical conditions for which outcome data are limited.

Methods: To conduct a systematic review, we included citations that evaluated occurrence of D-HT in SV physiology of TA, PA-IVS, and HX in English articles published between January 1998 and December 2017 based on inclusion and exclusion criteria, following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The Cochrane Risk of Bias in Non-Randomized Studies-Interventions (ROBINS-I) tool for non-randomized studies was used to assess the risk of bias. Read More

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http://dx.doi.org/10.1016/j.healun.2019.04.001DOI Listing

Pleuroparenchymal fibroelastosis (PPFE) treated with lung transplantation and review of the literature.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

A 26-year-old woman presented with a 15-year history of non-progressive dyspnoea. Chest imaging showed bilateral apical pleural and parenchymal scarring, pleural thickening and bronchiectasis. Pulmonary function tests showed a moderate restrictive defect. Read More

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http://dx.doi.org/10.1136/bcr-2019-229402DOI Listing

Frailty trajectories in adult lung transplantation: A cohort study.

J Heart Lung Transplant 2019 Mar 18. Epub 2019 Mar 18.

Departments of Medicine.

Background: Frailty is common in adults with advanced lung disease and is associated with death before and after lung transplantation. We aimed to determine whether frailty changes from before to after the lung transplant.

Methods: In a single-center, prospective cohort study among adults undergoing lung transplantation from 2010 to 2017, we assessed frailty by the Short Physical Performance Battery (SPPB; higher scores reflect less frailty) and Fried Frailty Phenotype (FFP; higher scores reflect greater frailty) before and repeatedly up to 36 months after transplant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498193142
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http://dx.doi.org/10.1016/j.healun.2019.03.006DOI Listing
March 2019
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The impact of non-HLA antibodies on outcomes after lung transplantation and implications for therapeutic approaches.

Authors:
Ramsey R Hachem

Hum Immunol 2019 Apr 17. Epub 2019 Apr 17.

Washington University School of Medicine, Division of Pulmonary & Critical Care, 4523 Clayton Ave., Campus Box 8052, St. Louis, MO 63110, United States. Electronic address:

The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-antigens have been identified that elicit autoimmune responses including collagen V, K-α 1 tubulin, angiotensin type 1 receptor, and endothelin type A receptor, but it is likely that other antigens elicit similar responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859193014
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http://dx.doi.org/10.1016/j.humimm.2019.04.008DOI Listing
April 2019
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Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Aims: Increasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and verified the dynamic change of miR-155 level in acute rejection (AR) using a rat renal transplantation model. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.043DOI Listing
April 2019
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Off-pump bilateral lung transplantation via median sternotomy: a novel approach with potential benefits.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Cardiothoracic Services, Freeman Hospital, Newcastle upon Tyne, United Kingdom. Electronic address:

The clamshell incision is worldwide the standard approach for bilateral lung transplantation. There is very limited experience with bilateral lung transplantation via median sternotomy so far and the use of cardiopulmonary bypass seems to be mandatory in all these cases accepting the potential disadvantages of the extracorporeal circulation. We describe a novel approach for bilateral lung transplantation as off-pump technique via median sternotomy which has the potential to combine the advantages of median sternotomy with less postoperative pain and better chest wall function and off-pump technique with reduced risk of primary graft dysfunction and bleeding complications. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.055DOI Listing

Lung clearance index for early detection of pulmonary complications after allo-HSCT in children.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Pulmonary chronic graft-vs-host disease (cGvHD) after hematopoietic stem cell transplantation (HSCT) is characterized by impairment of the small airways. Assessment of lung clearance index (LCI) gained from multiple breath washout (MBW) is more sensitive than spirometry in detection of small airways disease. The aim of this study was to describe the development of LCI during the first year after pediatric HSCT and how LCI relates to other pulmonary function parameters and cGvHD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24340
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http://dx.doi.org/10.1002/ppul.24340DOI Listing
April 2019
5 Reads

Not just the common cold: Rhinovirus infection in lung allograft recipients.

Respirology 2019 Apr 19. Epub 2019 Apr 19.

National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/resp.13571DOI Listing

Clinico-radiologic features of pleuroparenchymal fibroelastosis in children.

Pediatr Radiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Radiology, Texas Children's Hospital, 6701 Fannin St., Houston, TX, 77030, USA.

Background: Pleuroparenchymal fibroelastosis (PPFE) may be underdiagnosed clinically and radiographically in children with a remote history of cancer, leading to a delay in care and unnecessary lung biopsies.

Objective: To describe the characteristic clinical and radiologic findings of PPFE in a cohort of children to facilitate recognition and noninvasive diagnosis.

Materials And Methods: Clinical presentation, history of chemotherapy or radiation therapy, lung or bone marrow transplantation, and lung function testing and outcome were retrospectively extracted from the electronic medical records of eight children treated at our institution's pulmonary medicine clinic with histopathology confirmation of PPFE from 2008 to 2018. Read More

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http://link.springer.com/10.1007/s00247-019-04405-5
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http://dx.doi.org/10.1007/s00247-019-04405-5DOI Listing
April 2019
2 Reads

Addressing lung transplant with adults with cystic fibrosis: A qualitative analysis of patients' perspectives and experiences.

J Cyst Fibros 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA, USA.

Referral for lung transplantation is a complex process that typically begins with a discussion in cystic fibrosis (CF) clinic. We performed a secondary analysis of interviews conducted at the University of Washington CF Clinic as part of a study of unmet palliative care needs, June 2015 - January 2016, among adults with moderate-to-severe CF-related lung disease. Content analysis methods were used to identify themes related to discussion of lung transplant in CF clinic. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.007DOI Listing

Epithelial Cell Death Markers in Bronchoalveolar Lavage Correlate with Chronic Lung Allograft Dysfunction Subtypes and Survival in Lung Transplant Recipients - a single-center retrospective cohort study.

Transpl Int 2019 Apr 19. Epub 2019 Apr 19.

Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.

Background: Chronic lung allograft dysfunction (CLAD) remains the leading cause of late death after lung transplantation. Epithelial injury is thought to be a key event in the pathogenesis of CLAD. M30 and M65 are fragments of cytokeratin-18 released specifically during epithelial cell apoptosis and total cell death, respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13444
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http://dx.doi.org/10.1111/tri.13444DOI Listing
April 2019
1 Read

Nutrition-related factors associated with waiting list mortality in patients with interstitial lung disease: a retrospective cohort study.

Clin Transplant 2019 Apr 19:e13566. Epub 2019 Apr 19.

Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto-city, Kyoto, Japan.

Japanese patients with interstitial lung disease (ILD) sometimes die waiting for lung transplantation (LTx) because it takes about 2 years to receive it in Japan. We evaluated nutrition-related factors associated with waiting list mortality. Seventy-six ILD patients were hospitalized in Kyoto University Hospital at registration for LTx from 2013 to 2015. Read More

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http://dx.doi.org/10.1111/ctr.13566DOI Listing
April 2019
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Coronary artery air embolism complicating a CT-guided percutaneous lung biopsy.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):81-84

Department of Medical Oncology and Stem Cell Transplantation, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

Coronary arterial air embolism is an extremely rare but readily recognizable condition on computed tomography (CT) that may complicate a lung biopsy. We present an incidence of symptomatic air embolism into the right coronary artery during a percutaneous CT-guided lung biopsy that was successfully recognized during the procedure and managed accordingly. An active search for this complication should be made when the patient deteriorates on table and the usual complications (pneumothorax, vasovagal shock, etc. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_347_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467034PMC
April 2019
1 Read

Health-related quality of life in sickle cell disease.

Nat Rev Dis Primers 2019 Apr 18;5(1):27. Epub 2019 Apr 18.

Division of General Internal Medicine, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

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http://www.nature.com/articles/s41572-019-0080-5
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http://dx.doi.org/10.1038/s41572-019-0080-5DOI Listing
April 2019
2 Reads

DireCt Lung Ultrasound Evaluation (CLUE): A novel technique for monitoring extravascular lung water in donor lungs.

J Heart Lung Transplant 2019 Mar 13. Epub 2019 Mar 13.

Department of Inflammation and Immunology, Lerner Research Institute, Cleveland, Ohio, USA; Department of Thoracic and Cardiovascular Surgery, Cleveland, Ohio, USA; Transplant Center, Cleveland, Ohio, USA. Electronic address:

Background: Extravascular lung water (EVLW) could change in donor lungs in a time-dependent fashion during procurement or ex-vivo lung perfusion (EVLP) and may vary across different zones. Current techniques for EVLW assessment are either subjective, general estimation, or not feasible in the clinical setting. An accurate and non-invasive diagnostic tool for EVLW would be desirable for donor lung assessment and management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498193142
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http://dx.doi.org/10.1016/j.healun.2019.03.005DOI Listing
March 2019
1 Read

Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis.

BMC Pulm Med 2019 Apr 18;19(1):81. Epub 2019 Apr 18.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the clinical characteristics and outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods: We retrospectively reviewed the diameters of the pulmonary artery and aorta on chest CT, clinical characteristics, and results of other examinations in 303 patients at the time of initial diagnosis of IPF at our tertiary care center between 2011 and 2015. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-019-0843-5DOI Listing
April 2019
3 Reads

Lung transplantation and beyond: continued challenges in the wake of significant progress.

J Thorac Dis 2019 Mar;11(Suppl 3):S413-S416

Division of Cardiovascular Surgery, Temple University Health System and Lewis Katz School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.21037/jtd.2018.11.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424733PMC

Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.

Swiss Med Wkly 2019 Apr 17;149:w20054. Epub 2019 Apr 17.

Clinic for Cardiovascular Surgery, University Heart Centre, Zurich, Switzerland.

Aims Of The Study: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital. This study reports the results of the largest ECMO transportation programme in Switzerland and describes its feasibility and safety. Read More

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http://dx.doi.org/10.4414/smw.2019.20054DOI Listing
April 2019
2 Reads

Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity.

JCO Clin Cancer Inform 2019 Apr;3:1-10

1 All authors: Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from pre-existence or by evolving new genotypes and traits. Intratumor heterogeneity serves as a reservoir for resistance, which often occurs as a result of the selection of minor cellular subclones. Read More

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http://dx.doi.org/10.1200/CCI.18.00074DOI Listing
April 2019
1 Read

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regen Med 2019 Mar 27;14(3):165-177. Epub 2019 Feb 27.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

To determine the efficiency of mesenchymal stem cells (MSCs) of different sources on airway epithelial cells regeneration and track where and to what extent transplanted MSCs home to injured tissues. We performed DiO-labeled human bone marrow-derived MSCs (hBMSCs) or human chorionic villi-derived MSCs transplantation studies using naphthalene-induced airway injury animal models. Compared with human chorionic villi-derived MSCs, hBMSCs facilitated airway epithelium regeneration faster and better from day 5 after transplantation; moreover, more transplanted hBMSCs distributed in injured lung tissues at the early stage of postinjury, which was mediated by C-X-C motif chemokine ligand 12. Read More

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http://dx.doi.org/10.2217/rme-2018-0152DOI Listing

Early clear cell "sugar" lung cancer management: A case report and a brief literature review.

Thorac Cancer 2019 Apr 16. Epub 2019 Apr 16.

UOC of Oncology, University of Rome, Aprilia, Italy.

A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as "sugar cancer," that occurred in a 74 year-old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1759-7714.13
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http://dx.doi.org/10.1111/1759-7714.13077DOI Listing
April 2019
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Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid.

Pharmacogenomics J 2019 Apr 17. Epub 2019 Apr 17.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University in Saint Louis, Saint Louis, MO, USA.

Single-nucleotide polymorphisms (SNPs) in genes involved in mycophenolic acid (MPA) metabolism have been shown to contribute to variable MPA exposure, but their clinical effects are unclear. We aimed to determine if SNPs in key genes in MPA metabolism affect outcomes after lung transplantation. We performed a retrospective cohort study of 275 lung transplant recipients, 228 receiving mycophenolic acid and a control group of 47 receiving azathioprine. Read More

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http://dx.doi.org/10.1038/s41397-019-0086-0DOI Listing

The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish.

Development 2019 Apr 16. Epub 2019 Apr 16.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany

Tissue morphogenesis requires changes in cell-cell adhesion as well as in cell shape and polarity. Cardiac trabeculation is a morphogenetic process essential to form a functional ventricular wall. Here we show that zebrafish hearts lacking Crb2a, a component of the Crumbs polarity complex, display compact wall integrity defects and fail to form trabeculae. Read More

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http://dx.doi.org/10.1242/dev.171207DOI Listing
April 2019
1 Read

An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.

JCI Insight 2019 Apr 16;5. Epub 2019 Apr 16.

Obliterative bronchiolitis (OB) is a poorly understood airway disease characterized by the generation of fibrotic bronchiolar occlusions. In the lung transplant setting, OB is a pathological manifestation of bronchiolitis obliterans syndrome (BOS), which is a major impediment to long-term recipient survival. Club cells play a key role in bronchiolar epithelial repair, but whether they promote lung transplant tolerance through preventing OB remains unclear. Read More

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http://dx.doi.org/10.1172/jci.insight.124732DOI Listing
April 2019
3 Reads

[The first 25 years of lung transplantations in Denmark].

Ugeskr Laeger 2019 Apr;181(15)

Lung transplantation (LTx) has been performed in Denmark since 1992, and chronic obstructive pulmonary disease and interstitial lung diseases are the major indications. All candidates are subject to an intensive evaluation before being accepted for LTx. Follow-up after transplantation is life-long and includes immunosuppressive medication with a high risk of side effects. Read More

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April 2019
2 Reads

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2019 Apr 16. Epub 2019 Apr 16.

Berlin-Brandenburg Center for Regenerative Therapies, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) Berlin, Department of Cardiology, Campus Virchow Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany.

Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. Read More

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http://dx.doi.org/10.1002/ejhf.1461DOI Listing
April 2019
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6.526 Impact Factor

Trends and hospital outcomes of lung transplantation among patients with and without chronic obstructive pulmonary disease in Spain: a national population-based study (2001-2015).

Int J Chron Obstruct Pulmon Dis 2019 27;14:729-737. Epub 2019 Mar 27.

Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Alcorcón, Madrid, Spain,

Purpose: To describe trends from 2001 to 2015 in incidence and in-hospital outcomes of patients suffering or not suffering from COPD who had undergone lung transplantation (LTx) in Spain.

Methods: We used the Spanish National Hospital Discharge Database to select all admissions for LTx. Incidence was estimated overall and according to the presence of COPD. Read More

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http://dx.doi.org/10.2147/COPD.S189010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443219PMC
March 2019
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Question 13: Can we predict the need for lung transplantation in children with cystic fibrosis?

Paediatr Respir Rev 2019 Feb 19. Epub 2019 Feb 19.

Discipline of Child & Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15260542193001
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http://dx.doi.org/10.1016/j.prrv.2019.02.002DOI Listing
February 2019
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Accelerated Silicosis-An Emerging Epidemic Associated with Engineered Stone. Comment on Leso, V. et al. Artificial Stone Associated Silicosis: A Systematic Review. 2019, (4), 568, doi:10.3390/ijerph16040568.

Authors:
Graeme Edwards

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

The Work Doctor, Gold Coast, QLD 4214 Queensland, Australia.

The systematic review by Leso et al. (16 February 2019) is a timely contribution to the body of knowledge concerning silicosis. It highlights the lack of quality data necessary to inform both occupational health risk management and the clinical management of workers exposed to respirable crystalline silica. Read More

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http://dx.doi.org/10.3390/ijerph16071179DOI Listing
April 2019
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Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells.

Exp Hematol 2019 Apr 12. Epub 2019 Apr 12.

National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NH), Bethesda, MD 20892, USA. Electronic address:

A causal link between hematopoietic stem/progenitor cell (HSPC) dysfunction and DNA damage accrual has been proposed. Clinically relevant strategies to maintain genome integrity in these cells are needed. Here we report that eltrombopag, a small molecule agonist of the thrombopoietin (TPO) receptor used in the clinic, promotes DNA double strand break (DSB) repair in human HSPCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X193013
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http://dx.doi.org/10.1016/j.exphem.2019.03.002DOI Listing
April 2019
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Staphylococcal driveline infections are the predominant type of left ventricular assist device associated infections in Singapore.

Infect Dis (Lond) 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Department of Infectious Diseases , Singapore General Hospital , Singapore.

Background: Left ventricular assist device (LVAD) associated infections (LVADIs) have substantial morbidity and mortality. We aim to describe the incidence and epidemiology of LVADIs in an Asian cohort. This is currently not well studied. Read More

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http://dx.doi.org/10.1080/23744235.2019.1592216DOI Listing
April 2019
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A Novel Mutation in Chronic Granulomatous Disease: Treating the Family, Not Just the Patient.

Front Pediatr 2019 28;7:107. Epub 2019 Mar 28.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States.

Chronic Granulomatous Disease (CGD) is caused by genetic defects in the phagocyte NADPH oxidase leading to potentially severe infections with catalase positive micro-organisms. With the innate immune system being affected this disease usually presents before the age of 5 years with infections involving the skin, lung, liver or lymphnodes. Infections with specific catalase positive organisms, especially and prompt a workup for CGD in affected patients. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00107/
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http://dx.doi.org/10.3389/fped.2019.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447646PMC
March 2019
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Risk Factors for Developing Nonmelanoma Skin Cancer after Lung Transplantation.

J Skin Cancer 2019 10;2019:7089482. Epub 2019 Mar 10.

Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Background: Nonmelanoma skin cancer (NSMC) is the most common malignancy after organ transplantation. Lung transplant recipients (LTRs) are particularly prone to develop NMSC as compared to renal or hepatic transplant recipients due to higher dosages of immunosuppression needed. Everolimus, an immunosuppressant used in organ transplant recipients, is thought to inherit a lower risk for NMSC than calcineurin inhibitors, especially in renal transplant recipients. Read More

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http://dx.doi.org/10.1155/2019/7089482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431522PMC
March 2019
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A 1-Month Physical Therapy-Based Outpatient Program for Adults Awaiting Lung Transplantation: A Retrospective Analysis of Exercise Capacity, Symptoms, and Quality of Life.

Cardiopulm Phys Ther J 2019 Apr;30(2):61-69

Duke University School of Medicine, Departments of Orthopaedic Surgery, Medicine, Cell Biology.

Purpose: Rehabilitation can improve health outcomes in candidates for lung transplantation. The purpose of this study was to retrospectively evaluate the effect of a one-month physical therapy (PT)-based outpatient program on exercise capacity, symptoms, quality of life and examine predictors of functional outcome changes in adults awaiting lung transplantation.

Methods: Participants (n=141) completed a 23-session exercise and educational program over one month. Read More

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http://dx.doi.org/10.1097/CPT.0000000000000087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456901PMC
April 2019
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Left ventricular lusitropy and primary graft dysfunction in lung transplantation.

J Heart Lung Transplant 2019 Apr 4. Epub 2019 Apr 4.

Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.healun.2019.03.013DOI Listing
April 2019
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Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation.

Transplant Rev (Orlando) 2019 Apr 4. Epub 2019 Apr 4.

Viro-immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Solid organ transplantation (SOT) recipients receive immunosuppressive therapy to avoid rejection of the transplanted organ. Immunosuppressive therapy increases the risk of infections. However, no existing marker reliably reveals the status of the immune function in SOT recipients. Read More

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http://dx.doi.org/10.1016/j.trre.2019.03.004DOI Listing
April 2019
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Angiotensin II type I receptor antibodies in thoracic transplantation.

Hum Immunol 2019 Apr 10. Epub 2019 Apr 10.

HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA, United States.

Angiotensin II type I receptor (AT1R) is a critical player in regulating vasoconstriction, blood pressure, sodium retention. Even though AT1R has limited polymorphism, AT1R antibodies have been detected in several diseases. The role of AT1R antibodies in transplantation is first reported in kidney transplant, and then identified in heart and lung transplants. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.04.007DOI Listing
April 2019
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Risk Analysis of Perioperative Death in Lung Transplant Patients With Severe Idiopathic Pulmonary Hypertension.

Transplant Proc 2019 Apr 8;51(3):875-879. Epub 2019 Jan 8.

Department of Lung Transplantation, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, China. Electronic address:

Objective: To investigate the risk factors for perioperative mortality in patients with severe idiopathic pulmonary hypertension (IPAH) undergoing lung transplantation (LTx).

Methods: Twenty-two IPAH patients were included in the study and were divided 2 groups: a case group with early death post LTx (n = 5, 22.7%) and the remaining 17 recipients (87. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.024DOI Listing
April 2019
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