54,148 results match your criteria Transplantation Lung

Low-intensity immunosuppressive therapy for chronic graft-versus-host disease.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Jichi Medical University Saitama Medical Center. Electronic address:

In general, an initial systemic treatment for chronic graft-versus-host disease (cGVHD) is 0.5 to 1 mg/kg of prednisolone (PSL). However, patients without high-risk features are sometimes treated with calcineurin inhibitors (CI) or PSL at lower doses. Read More

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New-onset Obesity After Lung Transplantation: Incidence, Risk Factors, and Clinical Outcomes.

Transplantation 2022 Jun 24. Epub 2022 Jun 24.

Department of Nutrition, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.

Background: Lung transplant (LTx) recipients who gain weight after transplantation may experience an upward shift in body mass index (BMI) that places them in the obese category. The incidence, risk factors, and impact on metabolic health and mortality of new-onset obesity have not been documented in the LTx setting.

Methods: This single-center retrospective study included 564 LTx recipients. Read More

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Updated Views on Neutrophil Responses in Ischemia-Reperfusion Injury.

Transplantation 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgery, Washington University School of Medicine, Saint Louis, MO.

Ischemia-reperfusion injury is an inevitable event during organ transplantation and represents a primary risk factor for the development of early graft dysfunction in lung, heart, liver, and kidney transplant recipients. Recent studies have implicated recipient neutrophils as key mediators of this process and also have found that early innate immune responses after transplantation can ultimately augment adaptive alloimmunity and affect late graft outcomes. Here, we discuss signaling pathways involved in neutrophil recruitment and activation after ischemia-mediated graft injury in solid organ transplantation with an emphasis on lung allografts, which have been the focus of recent studies. Read More

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[Two Cases of Robot-Assisted Total Pelvic Exenteration and Intracorporeal Ileal Conduit forLocally Advanced Rectal Cancer].

Hinyokika Kiyo 2022 May;68(5):155-159

The Department of Digestive Surgery and Transplantation, Tokushima University Graduate School of Biomedical Sciences.

We describe two cases of locally advanced rectal cancer (LARC) treated with robot-assisted total pelvic exenteration (Ra-TPE) and intracorporeal ileal conduit (ICIC). The first case was in a 71-year-old man with LARC (RbP, T4bN2bM0, cStage IIIc). He was started on bevacizumab+S-1/oxaliplatin therapy in July 2019. Read More

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Limitations of Arterial Partial Pressure of Oxygen to Fraction of Inspired Oxygen Ratio for the Evaluation of Donor Lung Function.

Artif Organs 2022 Jun 23. Epub 2022 Jun 23.

Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Background: Evaluation of donor lung function relies on the arterial oxygen partial pressure to inspired oxygen fraction ratio (PaO /FiO ) measurement. Hemodynamic, metabolic derangements, and therapeutic intervention occurring during brain dead observation may influence the evaluation of gas exchange.

Methods: We performed a mathematical analysis to explore the influence of the extrapulmonary determinants on the interpretation of PaO /FiO in the brain-dead donor and during Ex-Vivo Lung Perfusion (EVLP). Read More

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Transbronchial Cryobiopsy Compared to Forceps Biopsy for Diagnosis of Acute Cellular Rejection in Lung Transplants: Analysis of 63 Consecutive Procedures.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Department of Pulmonology, Center of Lung Transplantation, Center of Adult Cystic Fibrosis, Interventional Lung Center, University Hospital Zurich, 8091 Zurich, Switzerland.

Background: Acute cellular rejection (ACR) is a complication after lung transplantation (LTx). The diagnosis of ACR is based on histologic findings using transbronchial forceps biopsy (FB). However, its diagnostic accuracy is limited because of the small biopsy size and crush artifacts. Read More

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How COVID-19 Affects Lung Transplantation: A Comprehensive Review.

J Clin Med 2022 Jun 18;11(12). Epub 2022 Jun 18.

Department of Immunology, Second Faculty of Medicine, Charles University, University Hospital Motol, 150 06 Prague, Czech Republic.

Lung transplant (LuTx) recipients are at a higher risk of developing serious illnesses from COVID-19, and thus, we have closely reviewed the consequences of the COVID-19 pandemic on lung transplantation. In most transplant centers, the overall LuTx activity significantly declined and led to a specific period of restricting lung transplantation to urgent cases. Moreover, several transplant centers reported difficulties due to the shortage of ICU capacities. Read More

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Intratracheal Transplantation of Mesenchymal Stem Cells Attenuates Hyperoxia-Induced Microbial Dysbiosis in the Lungs, Brain, and Gut in Newborn Rats.

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.

We attempted to determine whether intratracheal (IT) transplantation of mesenchymal stem cells (MSCs) could simultaneously attenuate hyperoxia-induced lung injuries and microbial dysbiosis of the lungs, brain, and gut in newborn rats. Newborn rats were exposed to hyperoxia (90% oxygen) for 14 days. Human umbilical cord blood-derived MSCs (5 × 10) were transplanted via the IT route on postnatal day (P) five. Read More

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Application of Place-Based Methods to Lung Transplant Medicine.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

GIS Health & Hazards Lab, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Lung transplantation is an increasingly common lifesaving therapy for patients with fatal lung diseases, but this intervention has a critical limitation as median survival after LT is merely 5.5 years. Despite the profound impact of place-based factors on lung health, this has not been rigorously investigated in LT recipients-a vulnerable population due to the lifelong need for daily life-sustaining immunosuppression medications. Read More

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Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress.

J Immunother Cancer 2022 Jun;10(6)

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Background: Adoptive cell therapy using cytotoxic lymphocytes is an efficient immunotherapy against solid and hematological cancers. However, elevated levels of reactive oxygen species (ROS) in the hostile tumor microenvironment can impair NK cell and T cell function. Auranofin, a gold (I)-containing phosphine compound, is a strong activator of the transcription factor Nrf2. Read More

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Heart-Lung Transplantation - technical modifications to simplify the procedure.

Ann Thorac Surg 2022 Jun 20. Epub 2022 Jun 20.

Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, Australia.

Heart-lung transplantation is a mature therapy but has perioperative complications such as phrenic nerve dysfunction and mediastinal bleeding. We report our technical modifications to simplify the procedure. Read More

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Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies.

Antiviral Res 2022 Jun 20:105367. Epub 2022 Jun 20.

Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, CA, USA; Department of Microbiology and Immunology, Stanford University, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to global health. We previously reported that AAK1, BIKE and GAK, members of the Numb-associated kinase family, control intracellular trafficking of multiple RNA viruses during viral entry and assembly/egress. Here, using both genetic and pharmacological approaches, we probe the functional relevance of NAKs for SARS-CoV-2 infection. Read More

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Biomarker Development Using Liquid Biopsy in Hepatocellular Carcinoma.

Semin Liver Dis 2022 May 23;42(2):188-201. Epub 2022 Jun 23.

Division of Liver Diseases, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Liver cancer incidence rate continues to increase and currently ranks third in the total number of annual deaths, behind only lung and colorectal cancer. Most patients with hepatocellular carcinoma (HCC) are diagnosed at advanced stages, and they live for less than 2 years after diagnosis on average. This contrasts with those diagnosed at an early stage, who can be cured with surgery. Read More

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Optimizing haematopoietic stem and progenitor cell apheresis collection from plerixafor-mobilized patients with sickle cell disease.

Br J Haematol 2022 Jun 23. Epub 2022 Jun 23.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

We adjusted haematopoietic stem and progenitor cell (HSPC) apheresis collection from patients with sickle cell disease (SCD) by targeting deep buffy coat collection using medium or low collection preference (CP), and by increasing anticoagulant-citrate-dextrose-solution A dosage. In 43 HSPC collections from plerixafor-mobilized adult patients with SCD, we increased the collection efficiency to 35.79% using medium CP and 82. Read More

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Lipid Profile Is Negatively Associated with Uremic Toxins in Patients with Kidney Failure-A Tri-National Cohort.

Toxins (Basel) 2022 Jun 16;14(6). Epub 2022 Jun 16.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

Patients with kidney failure (KF) have a high incidence of cardiovascular (CV) disease, partly driven by insufficient clearance of uremic toxins. Recent investigations have questioned the accepted effects of adverse lipid profile and CV risk in uremic patients. Therefore, we related a panel of uremic toxins previously associated with CV morbidity/mortality to a full lipid profile in a large, tri-national, cross-sectional cohort. Read More

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Clinical Considerations and Outcomes for Spine Surgery Patients with a History of Transplant: A Systematic Scoping Review Protocol.

Methods Protoc 2022 Jun 5;5(3). Epub 2022 Jun 5.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Spine surgery patients with a history of organ transplantation are a complex population due to their unique anesthetic considerations, immunologic profiles, drug interactions, and potential organ dysfunction. It is common for these patients to develop neck/back pain and pathology that warrants surgical intervention. However, there is a relative dearth of literature examining their outcomes and clinical considerations. Read More

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Integrated microbiome, metabolome, and proteome analysis identifies a novel interplay among commensal bacteria, metabolites and candidate targets in non-small cell lung cancer.

Clin Transl Med 2022 Jun;12(6):e947

The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China.

Background: Accumulation of evidence suggests that the gut microbiome, its specific metabolites, and differentially expressed proteins (DEPs) are related to non-small cell lung cancer (NSCLC) pathogenesis. We now report the influences of the gut microbiota, metabolites, and DEPs on the mediation of NSCLC's chronic inflammation and immune dysregulation.

Methods: We conducted 16S ribosomal RNA sequencing for the gut microbiome in healthy volunteers and NSCLC patients. Read More

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Eisenmenger Syndrome in Case of Extended Goldenhar Complex Treated With Heart-Lung Transplantation.

JACC Case Rep 2022 Jun 15;4(12):699-703. Epub 2022 Jun 15.

Division of Lung Transplant, Department of Transplantation, Mayo Clinic, Jacksonville, Florida, USA.

A patient diagnosed with expanded Goldenhar complex with oculoauriculovertebral spectrum complicated with complex pulmonary and congenital heart disease, underwent successful heart-lung transplantation 21 years ago, with excellent functional outcome and good quality of life. Heart-lung transplantation can be an option of care for patients with expanded Goldenhar complex. (). Read More

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CEPP: Canadian Extracorporeal Life Support (ECLS) Protocol Project.

CJC Open 2022 Jun 15;4(6):520-531. Epub 2022 Feb 15.

Division of Critical Care Medicine, Western University, London, Ontario, Canada.

Background: Extracorporeal life support (ECLS) is associated with high morbidity and mortality. Complications and mortality are higher at lower-volume centres. Most Canadian ECLS institutions are low-volume centres. Read More

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Feasibility of Virtual Assessment of Physical Frailty in Solid Organ Transplant Recipients: A Single Center, Observational Study.

Int J Telerehabil 2022 3;14(1):e6447. Epub 2022 Jun 3.

Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.

Objectives: To describe the feasibility of virtual assessments of physical frailty in solid organ transplant (SOT) recipients using a modified Fried Frailty Index (mFFI) and Short Physical Performance Battery (SPPB), and to describe the prevalence of frailty 12-months post-transplant using virtual assessment.

Methods: Virtual assessments were performed using an e-questionnaire and a video-call for functional tests. Feasibility variables included: internet quality, video-call duration, presence of a companion, and adverse events. Read More

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Histopathologically Confirmed Pulmonary Mucormycosis as a Complication of COVID-19: a Case Report from Romania and Insight into Pathology.

Maedica (Bucur) 2022 Mar;17(1):215-225

Department of Infectious Diseases, "Dr. Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania.

COVID-19 has proven to be an independent risk factor for secondary infectious complications. Amongst them, mucormycosis has recently been noticed more frequently than in the past. Caused by molds belonging to the order, this is a rare, but potentially fatal infection unless adequately treated. Read More

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Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.

Eur J Cancer 2022 Jun 19;171:203-231. Epub 2022 Jun 19.

Universite' de Paris, INSERM U976, AP-HP, Dermatology Department, Saint Louis Hospital, Paris, France. Electronic address:

Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all cutaneous malignancies. It is found predominantly in white populations and risk factors include advanced age, ultraviolet exposure, male sex, immunosuppression, such as AIDS/HIV infection, haematological malignancies or solid organ transplantation, and Merkel cell polyomavirus infection. MCC is an aggressive tumour with 26% of cases presenting lymph node involvement at diagnosis and 8% with distant metastases. Read More

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A case of severe respiratory failure due to interstitial pneumonia successfully bridged to lung transplantation from a brain-dead donor using 109-day veno-arterial extracorporeal membrane oxygenation.

J Artif Organs 2022 Jun 22. Epub 2022 Jun 22.

Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.

In Japan, successful cases of a bridge to lung transplantation (BTT) by extracorporeal membrane oxygenation (ECMO) are rare. We present the case of a man in his thirties, diagnosed with interstitial pneumonia 6 years prior and registered for lung transplant 1 year prior due to disease progression despite treatment. Due to the patient's worsening respiratory failure, he was transferred to our hospital for BTT by ECMO. Read More

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Establishing an economical and widely accessible DCD animal abattoir model for lung research using ex vivo lung perfusion.

Artif Organs 2022 Jun 22. Epub 2022 Jun 22.

Department of Cardio-thoracic surgery, University Medical Center Groningen, University of Groningen, The Netherlands.

Ex vivo lung perfusion (EVLP) is a preservation method that allows simultaneous testing and treatment of the lungs. However, use of EVLP is costly and requires access to lab animals and accompanying facilities. To increase the use of EVLP for research, we developed a method to perform EVLP using abattoir procured lungs. Read More

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Elevated Cell Free DNA in Respiratory Viral Infection and Associated Lung Allograft Dysfunction.

Am J Transplant 2022 Jun 21. Epub 2022 Jun 21.

Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore.

Respiratory viral infection (RVI) in lung transplant recipients (LTRs) is a risk for chronic lung allograft dysfunction (CLAD). We hypothesize that donor-derived cell-free DNA (%ddcfDNA), at the time of RVI predicts CLAD progression. We followed 39 LTRs with RVI enrolled in the Genomic Research Alliance for Transplantation for 1 year. Read More

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Pulmonary toxicity of mTOR inhibitors. Comparisons of two populations: Solid organ recipients and cancer patients.

Therapie 2022 Jun 8. Epub 2022 Jun 8.

Service de pneumologie, centre de compétence maladies pulmonaires rares, hôpital européen Georges-Pompidou, AP-HP, 75000 Paris, France; Université de Paris, 75000 Paris, France.

Introduction: Mammalian target of rapamycin (mTOR) inhibitors-associated pneumonitis (mTOR-IP) has long been described in solid organ recipients (T) patients but more recently in cancer (K) patients. Its overall characteristics have never been compared between these 2 populations. The aim of this study was to compare them in terms of presentation, severity and outcome in T and in K patients. Read More

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Task Force report: European Respiratory Society statement for defining respiratory exacerbations in children and adolescents with bronchiectasis for clinical trials.

Eur Respir J 2022 Jun 21. Epub 2022 Jun 21.

Pediatric Asthma and Cough Centre, Istituti Ospedalieri Bergamaschi, University and Research Hospitals, Bergamo, Italy.

Bronchiectasis is being diagnosed increasingly in children and adolescents. Recurrent respiratory exacerbations are common in children and adolescents with this chronic pulmonary disorder. Respiratory exacerbations are associated with an impaired quality-of-life, poorer long-term clinical outcomes and substantial costs to the family and health systems. Read More

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[Management of immunocompromised renal transplant patients infected with coronavirus disease 2019].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 May;34(5):492-496

Department of Critical Care Medicine, Xinjiang People's Hospital, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. Corresponding author: Hu Rui, Email:

Objective: To analyze the treatment process of a renal transplant patient infected with coronavirus disease 2019 (COVID-19), and discuss the management strategy for the immunocompromised hosts.

Methods: The diagnosis and treatment of a case of transplant patients with COVID-19 admitted to Horgos designated hospital of Xinjiang Uygur Autonomous Region in October 2021 were reviewed. The medical history and laboratory and imaging examination treatment and outcome of this case were analyzed. Read More

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