9,530 results match your criteria Translocation Carcinoma


Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.

Eur J Med Chem 2019 Feb 7;167:187-199. Epub 2019 Feb 7.

School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China. Electronic address:

To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2), and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect. Combining the data of cytotoxicity, cytocompatibility and anti-inflammatory activity, 3-pyridyl and -CF substituted 67 may be the potential anti-hepatoma agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.02.020DOI Listing
February 2019

MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.

Carcinogenesis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen Pauwelsstrasse, Germany.

In Western countries, a rising incidence of obesity and type 2 diabetes correlates with an increase of non-alcoholic steatohepatitis (NASH)-a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). NASH is associated with chronic liver injury, triggering hepatocyte death and enhanced translocation of intestinal bacteria, leading to persistent liver inflammation through activation of Toll-like receptors and their adapter protein myeloid differentiation factor 88 (MyD88). Therefore, we investigated the role of MyD88 during progression from NASH to HCC using a mouse model of chronic liver injury (hepatocyte-specific deletion of nuclear factor κB essential modulator, Nemo; NemoΔhepa). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgy173DOI Listing
February 2019

Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation.

EBioMedicine 2019 Feb 11. Epub 2019 Feb 11.

University of Michigan, Biointerfaces Institute, Ann Arbor, MI, United States; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, Ann Arbor, MI, United States. Electronic address:

Background: Patient-derived xenograft (PDX) models have significantly enhanced cancer research, and often serve as a robust model. However, enhanced growth rate and altered pathological phenotype with serial passages have repeatedly been shown in adenoid cystic carcinoma (ACC) PDX tumors, which is a major concern.

Methods: We evaluated the fidelity of ACCs in their natural habitat by performing ACC orthotopic xenotransplantation (PDOX) in salivary glands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2019.02.011DOI Listing
February 2019

Two new compounds of Penicillium polonicum, an endophytic fungus from Camptotheca acuminata Decne.

Nat Prod Res 2019 Feb 13:1-5. Epub 2019 Feb 13.

a School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan , China.

To discover novel structural compounds which are producted by endophytic fungi, a primary chemical profiling of Camptotheca acuminata Decne derived endophytic fungus Penicillum polonicum had been taken. Two new compounds β-lactone polonicin A (1) and enoic acid polonicin B (2) together with seven known compounds 3-9 were isolated from Penicillum polonicum obtained from C. acuminata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2019.1569003DOI Listing
February 2019
0.919 Impact Factor

Oncolytic activity of canine distemper virus in canine mammary tubular adenocarcinoma cells.

Vet Comp Oncol 2019 Feb 12. Epub 2019 Feb 12.

The Clinical Department, College of Veterinary Medicine, China Agricultural University, P.R. China.

Canine distemper virus (CDV), bearing a close resemblance to measles virus, represents a promising candidate for oncolytic therapy; however, its application and underlying oncolytic mechanisms in canine mammary carcinoma cells remain to be explored. Here, we found that an attenuated canine distemper vaccine strain, CDV-L, efficiently infected and inhibited the growth of canine mammary tubular adenocarcinoma CIPp cells but not MDCK cells in vitro. Transcriptomic analysis of CDV-L-infected CIPp cells revealed substantially differentially expressed genes in apoptotic and NF-κB signaling pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vco.12466DOI Listing
February 2019

Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology.

Authors:
Douglas R Green

Cancer Cell 2019 Feb;35(2):163-165

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

PUMA is a pro-apoptotic Bcl-2 family protein that can act as a tumor suppressor or oncogene in different cancers. In this issue, Kim et al. show that PUMA, independent of its apoptotic function, enforces glycolytic metabolism by inhibiting the transport of pyruvate into the mitochondria, promoting hepatocellular carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.01.016DOI Listing
February 2019
1 Read

Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2.

Int J Biol Sci 2019 1;15(3):617-627. Epub 2019 Jan 1.

Department of Ultrasonography, China-Japan Union Hospital, Jilin University, Changchun, China.

Metformin, a common therapeutics for type 2 diabetics, was recently demonstrated to possess antitumor activity in various cancer types. However, its therapy effect in renal cell carcinoma (RCC) still remains controversial. In this study, we found that metformin treatment in RCC cells lead to activation of AMPK, which suppressed the cell proliferation under normal condition, but enhanced cell proliferation under glucose deprivation (GD) condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijbs.29689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367591PMC
January 2019
2 Reads

mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma.

Oncogene 2019 Feb 11. Epub 2019 Feb 11.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

EBV infection of preinvasive nasopharyngeal epithelium is believed to be an initiation step during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain poorly understood. Here we report a novel mechanism driving NPC metastasis through the EBV-encoded LMP1-mediated metabolic reprogramming, via activation of IGF1-mTORC2 signaling and nuclear acetylation of the Snail promoter by the PDHE1α, an enzyme involved in glucose metabolism. Mechanistically, EBV-LMP1 increases the cellular secretion of IGF1 which promotes phosphorylation of IGF1R to activate mTORC2/AKT signaling linking glucose metabolism to cell motility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-019-0749-yDOI Listing
February 2019
1 Read

Limonin attenuates the stemness of cervical carcinoma cells by promoting YAP nuclear-cytoplasmic translocation.

Food Chem Toxicol 2019 Feb 6. Epub 2019 Feb 6.

Department of Obstetrics, Henan Province Hospital of Traditional Chinese Medicine, No.6 Dongfeng Road, Jinshui District, Zhengzhou, 450002, China. Electronic address:

This work aimed to investigate the role and related mechanism of limonin in regulating the stemness of cervical carcinoma (CC) cells. In the present study, we constructed adriamycin-resistant CC cells and found that they exhibited greater stemness than parental cells. Additionally, limonin attenuated the stemness of CC cells that were resistant or sensitive to adriamycin, as evidenced by the decreases in spheroid formation capacity, stemness markers expression and ALDH1 activity, whereas limonin did not affect the viability of normal cervical epithelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2019.02.011DOI Listing
February 2019
1 Read

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis.

J Cancer 2019 1;10(3):737-748. Epub 2019 Jan 1.

Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China.

Papillary thyroid carcinoma (PTC) is the most commonly diagnosed endocrine cancer, and those with mutation have high recurrence rate and less favorable clinical behavior. Genistein having anti-carcinoma effects in various types of carcinomas as an estrogen analog, but the mechanism of Genistein in the progression of PTC remains unknown. Genistein significantly inhibits the proliferation and the invasion (P < 0. Read More

View Article

Download full-text PDF

Source
http://www.jcancer.org/v10p0737.htm
Publisher Site
http://dx.doi.org/10.7150/jca.28111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360420PMC
January 2019
4 Reads
2.639 Impact Factor

Histological and molecular characterization of TFEB-rearranged renal cell carcinomas.

Virchows Arch 2019 Jan 31. Epub 2019 Jan 31.

Department of Pathology and Molecular Pathology, University Hospital and University Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland.

The 2016 WHO Classification of Tumors of the Urinary System recognizes microphthalmia transcription factor (MiT) family translocation carcinomas as a separate entity among renal cell carcinomas. TFE3 and transcription factor EB (TFEB) are members of the MiT family for which chromosomal rearrangements have been associated with renal cell carcinoma formation. TFEB translocation renal cell carcinoma is a rare tumor harboring a t(6;11)(p21;q12) translocation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-019-02526-8DOI Listing
January 2019
1 Read

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.

Free Radic Biol Med 2019 Jan 29;134:458-467. Epub 2019 Jan 29.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Beijing Key Laboratory for Cancer Invasion and Metastasis Research, Beijing International Cooperation Base for Science and Technology on China-UK Cancer Research, Beijing, 100069, China. Electronic address:

Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Protein succinylation influences cell metabolism, but its effects on ccRCC tumorigenesis remain largely uncharacterized. In this study, we investigated the lysine succinylome of ccRCC tissues by using tandem mass tag labeling, affinity enrichment, liquid chromatography-tandem mass spectrometry and integrated bioinformatics analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.030DOI Listing
January 2019
1 Read

[Clinicopathological characteristics of fumarate hydratase-deficient renal cell carcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):120-126

Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To investigate the clinicopathologic characteristics, molecular and genetic features, differential diagnoses and prognosis of fumarate hydratase-deficient renal cell carcinoma (FH-RCC). The immunohistochemical (IHC) expression of FH in 391 renal neoplasms in tissue chips collected from the Affiliated Hospital of Qingdao University and 971 Hospital of PLA Navy from January 2011 to December 2017 was evaluated. The clinicopathologic data of eight FH negative cases were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.009DOI Listing
February 2019
5 Reads

New entities, new technologies, new findings: A review of the cytologic features of recently established subtypes of renal cell carcinoma.

Cancer Cytopathol 2019 Feb 28;127(2):79-97. Epub 2019 Jan 28.

Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.

Several new renal tumor types with distinctive pathologic, epidemiologic, and genetic signatures have recently been adopted in the fourth edition of the World Health Organization classification. In succeeding years, the cytologic features of most of these new types have been described, adding to the trend of increasing diagnostic accuracy for most common renal cell carcinoma subtypes and the important diagnostic role of cytologic sampling in the management and personalization of therapy. The current article reviews the cytologic findings from these recently established renal cell carcinoma subtypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncy.22093DOI Listing
February 2019
1 Read

LIMS1 Promotes Pancreatic Cancer Cell Survival Under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation.

Clin Cancer Res 2019 Jan 24. Epub 2019 Jan 24.

Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital.

Purpose: Oxygen and glucose deprivation is a common feature of the solid tumor. Regulatory network underlying the adaptation of cancer cells to harsh microenvironment remains unclear. We determined the mechanistic role of LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) in cancer cell survival under oxygen-glucose deprivation conditions. Read More

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-3533DOI Listing
January 2019
3 Reads

Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma.

J Ovarian Res 2019 Jan 24;12(1). Epub 2019 Jan 24.

Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.

Background: Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene single-nucleotide polymorphisms (SNPs) adversely affect the outcome in some cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13048-019-0481-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345011PMC
January 2019
2 Reads

Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives.

Oncol Lett 2019 Feb 20;17(2):2020-2030. Epub 2018 Dec 20.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactors and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China.

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in brain development. is located on the short arm of chromosome 2 (2p23) and exchange of chromosomal segments with other genes, including nucleophosmin (), echinoderm microtubule-associated protein-like 4 () and -fused gene (), readily occurs. Such chromosomal translocation results in the formation of chimeric fusion oncoproteins, which possess potential oncogenic functions due to constitutive activation of ALK kinase. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2018.9856
Publisher Site
http://dx.doi.org/10.3892/ol.2018.9856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341817PMC
February 2019
7 Reads

Histidine-Rich Cell-Penetrating Peptide for Cancer Drug Delivery and its Uptake Mechanism.

Langmuir 2019 Jan 23. Epub 2019 Jan 23.

In this work, we report a drug delivery system based on the pH-responsive self-assembly and -disassembly behaviors of peptides. Here, a systematically designed histidine-rich lipidated peptide (NP1) is presented to encapsulate and deliver an anti-cancer drug ellipticine (EPT) into two model cells: non-small cell lung carcinoma and Chinese hamster ovary cells. The mechanism of pH-responsive peptide self-assembly and -disassembly involved in the drug encapsulation and release process are extensively investigated. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.langmuir.8b03175
Publisher Site
http://dx.doi.org/10.1021/acs.langmuir.8b03175DOI Listing
January 2019
5 Reads
4.457 Impact Factor

Clear Cell Papillary Renal Cell Carcinoma.

Arch Pathol Lab Med 2019 Jan 23. Epub 2019 Jan 23.

From the Department of Pathology, University of Texas Medical Branch, Galveston.

Clear cell papillary renal cell carcinoma (ccpRCC) is a recently recognized entity and represents the fourth most common variant of renal cell carcinoma (RCC). It has unique morphologic and immunohistochemical features and demonstrates an indolent clinical behavior. Microscopically, it may mimic other RCCs with clear cell features, such as clear cell RCC, translocation RCC, and papillary RCC with clear cell changes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2018-0121-RSDOI Listing
January 2019
1 Read

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.

Nat Commun 2019 01 21;10(1):368. Epub 2019 Jan 21.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany.

The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major components of saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] in AciCC that translocate active enhancer regions from the SCPP gene cluster to the region upstream of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) at 9q31. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-08069-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341107PMC
January 2019
2 Reads

Renal Medullary Carcinoma: a Report of the Current Literature.

Curr Urol Rep 2019 Jan 17;20(1). Epub 2019 Jan 17.

FINAER (Foundation for Research and Assistance in Kidney Disease), Palestina 525, 1182, Buenos Aires, Argentina.

Purpose Of The Review: We present an updated report of renal medullary carcinoma (RMC), a rare and aggressive condition.

Recent Findings: There is a majority of male patients, of African descent, in the second or third decade of life. In differential diagnosis, other tumors, such as malignant rhabdoid tumor (MRT), vinculin-anaplastic lymphoma kinase (VCL-ALK) translocation renal cell carcinoma, and collecting duct carcinoma, may present difficulties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11934-019-0865-9DOI Listing
January 2019
3 Reads

Su Yang Decoction induces human colon carcinoma cell apoptosis by activating caspases.

Oncol Lett 2019 Jan 26;17(1):422-431. Epub 2018 Oct 26.

Department of Pharmacology, College of Pharmaceutical Science, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China.

Su Yang Decoction (SYD) is a popular healthcare product comprised of various brassicaceous vegetables known to exhibit anticancer activity. However, the effects of SYD on tumor growth, following its combination with brassicaceous vegetables into a compound formula, require further investigation. In the present study, a quality control of SYD was subjected to high-performance liquid chromatography for the quantitative and qualitative determination of sulforaphane, the main anticancer component of SYD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2018.9625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313099PMC
January 2019
1 Read

Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma.

Cancer Sci 2019 Jan 16. Epub 2019 Jan 16.

Division of Cardiology, Departments of Internal Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The interleukin (IL)-6/glycoprotein (GP)130/signal transducer and activator of transcription (STAT)3 pathway is emerging as a target for the treatment of hepatocellular carcinoma. IL-6 binds to IL-6R, forming a binary complex, which further combines with GP130 to transduce extracellular signaling by activating STAT3. Therefore, blocking the interaction between IL-6 and GP130 may inhibit the IL-6/GP130/STAT3 signaling pathway and its biological effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.13940DOI Listing
January 2019
3 Reads

[Diagnostic and prognostic implications of MAML2 gene translocation in primary pulmonary mucoepidermoid carcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):26-30

Department of Pathology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

To investigate MAML2 gene-translocation in primary pulmonary mucoepidermoid carcinoma (PMEC) and pulmanary adenosquamous carcinoma, and the optimal diagnostic immunohistiochemical (IHC) panel in distinguishing PMEC from adenosqumous carcinoma. Twenty-four cases of PMEC and 44 adenosqumous carcinoma diagnosed in the Guangdong General Hospital were tested for MAML2 translocation by fluorescent in-situ hybridization (FISH) using tissue array. An IHC panel including TTF1, Napsin A, CK5/6, p63, p40 and Ki-67 was performed on the cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.01.006DOI Listing
January 2019
1 Read

Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis.

Biochem Biophys Res Commun 2019 Feb 11;509(4):855-861. Epub 2019 Jan 11.

Department of Hepatobiliary Surgery, the Second Affiliated Hospital & Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) of Chongqing Medical University, 40016, Chongqing, China. Electronic address:

Worldwide, hepatocellular carcinoma (HCC) remains a top instigator of cancer mortality. Previous clinical studies have revealed that low serum cholesterol predicts a poor outcome in HCC patients, but the potential role of cholesterol in the progression of HCC remains controversial. In the present study,we tested the influence of cholesterol on the progression of DEN-induced HCC by feeding mice with a high cholesterol diet (HCD) and by depriving cholesterol with atorvastatin, a widely used inhibitor of the mevalonate pathway. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X183286
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2018.12.181DOI Listing
February 2019
5 Reads

Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review.

BMC Cancer 2019 Jan 11;19(1):52. Epub 2019 Jan 11.

Department of Oral & Maxillofacial Surgery, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. Read More

View Article

Download full-text PDF

Source
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-019-5277-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329170PMC
January 2019
6 Reads

In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells.

Fundam Clin Pharmacol 2019 Jan 9. Epub 2019 Jan 9.

UPS, UMR 152 Pharma-DEV, Université Toulouse 3, Faculté des Sciences Pharmaceutiques, Université de Toulouse, 35 Chemin des Maraîchers, F-31062, Toulouse, France.

Liver cancer, of which human hepatocellular carcinoma (HCC) is the most common type, represents the second most common cause of death from cancer worldwide. To date, treatments remain mostly ineffective and efforts are made to discover new molecules or therapeutic strategies against HCC. Mortalin, an hsp70 chaperone protein, is overexpressed in various cancer, including HCC. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/fcp.12447
Publisher Site
http://dx.doi.org/10.1111/fcp.12447DOI Listing
January 2019
4 Reads

NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma.

Mod Pathol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

Microphthalmia-associated transcription factor (MiT) family translocation renal cell carcinoma harbors variable gene fusions involving either TFE3 or TFEB genes. Multiple 5' fusion partners for TFE3 have been reported, including ASPSCR1, CLTC, DVL2, LUC7L3, KHSRP, PRCC, PARP14, NONO, SFPQ1, MED15, and RBM10. Each of these fusion genes activates TFE3 transcription which can be detected by immunostaining. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41379-018-0191-7
Publisher Site
http://dx.doi.org/10.1038/s41379-018-0191-7DOI Listing
January 2019
2 Reads

Inhibition of Interleukin 10 Transcription through the SMAD2/3 Signaling Pathway by Ca-Activated K Channel K3.1 Activation in Human T-Cell Lymphoma HuT-78 Cells.

Mol Pharmacol 2019 Mar 8;95(3):294-302. Epub 2019 Jan 8.

Department of Pharmacology, Kyoto Pharmaceutical University, Kyoto, Japan (M.M., K.E., Y.H.) and Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan (M.M., J.K., H.K., K.E., S.M., S.O.)

The hyperpolarization induced by intermediate-conductance Ca-activated K channel (K3.1) activation increases the driving force for Ca influx, which generally promotes cell proliferation, migration, and cytokine production in immunocompetent cells. Interleukin-10 (IL-10) from tumor-infiltrating lymphocytes and macrophages, lymphoma, and carcinoma cells facilitates escape from cancer immune surveillance; however, the role of K3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.118.114405DOI Listing
March 2019
7 Reads

Implications of Na/I Symporter Transport to the Plasma Membrane for Thyroid Hormonogenesis and Radioiodide Therapy.

J Endocr Soc 2019 Jan 5;3(1):222-234. Epub 2018 Dec 5.

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Iodine is a crucial component of thyroid hormones; therefore, a key requirement for thyroid hormone biosynthesis is that iodide (I) be actively accumulated in the thyroid follicular cell. The ability of the thyroid epithelia to concentrate I is ultimately dependent on functional Na/ I symporter (NIS) expression at the plasma membrane. Underscoring the significance of NIS for thyroid physiology, loss-of-function mutations in the NIS-coding gene cause an I transport defect, resulting in dyshormonogenic congenital hypothyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/js.2018-00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316985PMC
January 2019
1 Read

PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.

Front Oncol 2018 17;8:611. Epub 2018 Dec 17.

Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Gluconeogenesis, generates glucose from small carbohydrate substrates, and drives the metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK-C), a rate-limiting enzyme in gluconeogenesis, initiates the gluconeogenesis process and is reportedly dysregulated in multiple types of cancer. Gluconeogenesis mainly occurs in the liver during fasting, and previous studies have demonstrated that PCK1 acts as a tumor suppressor in hepatocellular carcinoma (HCC); however, the role of PCK1 in cancer progression remains incompletely understood. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fonc.2018.00611/
Publisher Site
http://dx.doi.org/10.3389/fonc.2018.00611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304441PMC
December 2018
6 Reads

Down-regulation and nuclear localization of survivin by sodium butyrate induces caspase-dependent apoptosis in human oral mucoepidermoid carcinoma.

Oral Oncol 2019 Jan 5;88:160-167. Epub 2018 Dec 5.

Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:

Objective: Sodium butyrate (NaBu) is a histone deacetylase inhibitor that possesses an apoptotic ability. However, the molecular mechanism by which NaBu induces apoptosis in human oral mucoepidermoid carcinoma (MEC), a type of salivary gland tumor, remains unclear.

Materials And Methods: The anticancer effects of NaBu and its related molecular mechanisms were determined by trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole staining, live/dead assay, human apoptosis array, RT-PCR, western blotting, immunocytochemistry, preparation of nuclear fractions, and nude mice tumor xenograft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2018.11.032DOI Listing
January 2019
1 Read

Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.

Authors:
M V Bais

J Dent Res 2019 Jan 7:22034518816947. Epub 2019 Jan 7.

1 Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

The most common type of head and neck cancer, head and neck squamous cell carcinoma (HNSCC), can develop therapeutic resistance that complicates its treatment. The 5-y survival rate for HNSCC remains at ~50%, and improving these outcomes requires a better understanding of the pathogenesis of HNSCC. Studies of HNSCC using in vitro, ex vivo, and in vivo approaches provide a novel conceptual framework based on epigenetic mechanisms for developing future clinical applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0022034518816947DOI Listing
January 2019
2 Reads

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.

Mol Cancer 2019 01 4;18(1). Epub 2019 Jan 4.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, 832002, China.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat organ-confined and locally advanced ESCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12943-018-0930-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320601PMC
January 2019
3 Reads
4.257 Impact Factor

Bacterial translocation and risk of liver cancer in a Finnish cohort.

Cancer Epidemiol Biomarkers Prev 2019 Jan 2. Epub 2019 Jan 2.

Division of Cancer Epidemiology, National Cancer Institute

Background: Elevated systemic exposure to gut-derived bacterial products has been associated with hepatic inflammation and chronic liver diseases, potentially increasing the risk of liver cancer. However, only one prior study prospectively examined exposure to bacterial products in the circulation and risk of liver cancer, with a relatively limited coverage of biomarkers.

Methods: We conducted a nested case-control study (224 liver cancer cases and 224 matched controls) in a large cohort of Finnish male smokers followed from baseline (1985-1988) to 2014. Read More

View Article

Download full-text PDF

Source
http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
Publisher Site
http://dx.doi.org/10.1158/1055-9965.EPI-18-0240DOI Listing
January 2019
11 Reads

Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods.

PLoS Comput Biol 2019 Jan 2;15(1):e1006663. Epub 2019 Jan 2.

Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America.

N6-methyladenosine (m6A) is the most abundant methylation, existing in >25% of human mRNAs. Exciting recent discoveries indicate the close involvement of m6A in regulating many different aspects of mRNA metabolism and diseases like cancer. However, our current knowledge about how m6A levels are controlled and whether and how regulation of m6A levels of a specific gene can play a role in cancer and other diseases is mostly elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331136PMC
January 2019
3 Reads

c-MYB and DMTF1 in Cancer.

Cancer Invest 2019 Jan 2:1-20. Epub 2019 Jan 2.

a The Department of Pathology , Wake Forest University School of Medicine , Winston-Salem , NC , USA.

The c-Myb gene encodes a transcription factor that regulates cell proliferation, differentiation, and apoptosis through protein-protein interaction and transcriptional regulation of signaling pathways. The protein is frequently overexpressed in human leukemias, breast cancers, and other solid tumors suggesting that it is a bona fide oncogene. c-MYB is often overexpressed by translocation in human tumors with t(6;7)(q23;q34) resulting in c-MYB-TCRβ in T cell ALL, t(X;6)(p11;q23) with c-MYB-GATA1 in acute basophilic leukemia, and t(6;9)(q22-23;p23-24) with c-MYB-NF1B in adenoid cystic carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07357907.2018.1550090DOI Listing
January 2019
1 Read

AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop.

Biochem Biophys Res Commun 2019 Feb 28;509(2):535-540. Epub 2018 Dec 28.

Capital Medical University Affiliated Beijing You An Hospital, Beijing, 100069, China; Beijing Institute of Hepatology, Beijing, 100069, China. Electronic address:

AZD3759 is a tyrosine kinase inhibitor and has an encouraging future in treating brain metastases of non-small cell lung cancer. Here, we determined that AZD3759 suppressed the viability of HepG2 cells, a hepatoma cell line, and induced their apoptosis, suggesting a new therapeutic potential of AZD3759 in hepatocellular carcinoma (HCC) treatment. Furthermore, we found that the activation of p53-SMAD family member 4 (SMAD4) positive feedback loop was involved in the induction of bulks of apoptosis in HepG2 cells in response to AZD3759 treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.12.102DOI Listing
February 2019
1 Read

CXCL17 promotes cell metastasis and inhibits autophagy via the LKB1-AMPK pathway in hepatocellular carcinoma.

Gene 2019 Mar 28;690:129-136. Epub 2018 Dec 28.

Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen, Guangdong, China; Department of Hepatic & Pancreatic Surgery, The First People's Hospital of Foshan, Foshan, Guangdong, China. Electronic address:

As an innovative CXC chemokine, CXCL17 has a mysterious clinical significance and modulating influence on hepatocellular carcinoma (HCC). Our study examined the activity and mechanisms of CXCL17 on growth, autophagy, and metastasis of HCC. Upregulation of CXCL17 expression was observed in HCC, which is correlated with poorer histological stages and outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2018.12.043DOI Listing
March 2019
1 Read
2.138 Impact Factor

Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders.

J Immunother Cancer 2018 Dec 27;6(1):159. Epub 2018 Dec 27.

Department of Medical Oncology, Hôpital Universitaire Pitié-Salpétrière, Paris, France.

Background: Microphthalmia Transcription Factor (MITF)family translocation renal cell carcinoma (tRCC) is a rare RCC subtype harboring TFE3/TFEB translocations. The prognosis in the metastatic (m) setting is poor. Programmed death ligand-1 expression was reported in 90% of cases, prompting us to analyze the benefit of immune checkpoint inhibitors (ICI) in this population. Read More

View Article

Download full-text PDF

Source
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
Publisher Site
http://dx.doi.org/10.1186/s40425-018-0482-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307255PMC
December 2018
5 Reads

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts.

J Exp Clin Cancer Res 2018 Dec 27;37(1):324. Epub 2018 Dec 27.

Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.

Background: Hepatocellular carcinoma (HCC) remains a global challenge due to its high morbidity and mortality rates as well as poor response to treatment. The communication between tumor-derived elements and stroma plays a critical role in facilitating cancer progression of HCC. Exosomes are small extracellular vesicles (EVs) that are released from the cells upon fusion of multivesicular bodies with the plasma membrane. Read More

View Article

Download full-text PDF

Source
https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
Publisher Site
http://dx.doi.org/10.1186/s13046-018-0965-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307162PMC
December 2018
16 Reads

Chronic cadmium exposure aggravates malignant phenotypes of nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway via hypermethylation of the casein kinase 1α promoter.

Cancer Manag Res 2019 19;11:81-93. Epub 2018 Dec 19.

Laboratory of Environmental Medicine and Developmental Toxicology, Guangzhou and Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, People's Republic of China,

Background: Our previous study has shown that cadmium (Cd) exposure is not only a risk factor for nasopharyngeal carcinoma (NPC), but also correlated with the clinical stage and lymph node metastasis. However, the underlying molecular events of Cd involved in NPC progression remain to be elucidated.

Purpose: The objective of this study was to decipher how Cd impacts the malignant phenotypes of NPC cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S171200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304082PMC
December 2018
2 Reads

Clinical significance and effect of MTDH/AEG-1 in bladder urothelial cancer: a study based on immunohistochemistry, RNA-seq, and in vitro verification.

Cancer Manag Res 2018 14;10:6921-6936. Epub 2018 Dec 14.

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, China.

Background: Overexpression of has been implicated in various cancers. However, the clinical significance and the potential biological functions of MTDH/AEG-1 in bladder urothelial carcinoma (BUC) are not established.

Methods: In this study, the expression of MTDH/AEG-1in BUC was measured using the Cancer Genome Atlas (TCGA) database and immunohistochemistry, together with a meta-analysis, to investigate the expression and diagnostic value of MTDH/AEG-1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S176887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298393PMC
December 2018
1 Read

Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma.

Phytother Res 2018 Dec 18. Epub 2018 Dec 18.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

Hepatocellular carcinoma (HCC) is a biologically complex disease. Combination chemotherapy is a good strategy after surgery treatment. In this study, we report that berberine combined with HMQ1611 (BCH) had a good synergistic effect on the HCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ptr.6267DOI Listing
December 2018
2 Reads

Clear cell renal cell carcinoma with wild-type von Hippel-Lindau gene: a non-existent or new tumour entity?

Histopathology 2019 Jan;74(1):60-67

Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland.

The current World Health Organisation (WHO) classification of renal tumours is based on characteristic histological features or specific molecular alterations. von Hippel-Lindau (VHL) alteration is the hallmark of clear cell renal cell carcinoma (RCC). After identification of the MiT translocation family of tumours, clear cell papillary renal cancer and others, the group of ccRCC with wild-type VHL is small. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/his.13749
Publisher Site
http://dx.doi.org/10.1111/his.13749DOI Listing
January 2019
9 Reads

Multifunctional selenium nanoparticles with Galangin-induced HepG2 cell apoptosis through p38 and AKT signalling pathway.

R Soc Open Sci 2018 Nov 28;5(11):180509. Epub 2018 Nov 28.

Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, People's Republic of China.

The morbidity and mortality of hepatocellular carcinoma, the most common cancer, are increasing continuously worldwide. Galangin (Ga) has been demonstrated to possess anti-cancer effect, but the efficacy of Ga was limited by its low permeability and poor solubility. To develop aqueous formulation and improve the anti-cancer activity of Ga, surface decoration of functionalized selenium nanoparticles with Ga (Se@Ga) was synthesized in the present study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsos.180509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281927PMC
November 2018
2 Reads

Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8.

J Biol Chem 2019 Feb 18;294(6):2046-2059. Epub 2018 Dec 18.

From the State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China

Insulin-induced gene 1 (INSIG1) regulates sterol synthesis by mediating the activation of sterol regulatory element-binding protein (SREBP) and the degradation of the HMG-CoA reductase (HMGCR). INSIG1 is up-regulated during HIV-1 infection, but its role in HIV-1 infection is unknown. In this report, using pseudovirus production, protein overexpression, and gene knockouts, we found that INSIG1 inhibits HIV-1 production by accelerating the degradation of the HIV-1 Gag protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.004630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369274PMC
February 2019
1 Read

Effects of Platycodin D on S100A8/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells.

Int Immunopharmacol 2019 Feb 15;67:239-247. Epub 2018 Dec 15.

Institute of Chinese Traditional Surgery, LongHua Hospital Shanghai University of Traditional Chinese Medicine, 725 Wanpingnan Road, Shanghai 200032, China; Department of Breast Surgery, LongHua Hospital Shanghai University of Traditional Chinese Medicine, 725 Wanpingnan Road, Shanghai 200032, China. Electronic address:

Activation of the inflammatory signaling pathway is the most vital part of the pre-metastatic events of breast cancer. Platycodin D (PlaD) shows favorable pharmacological activities in anti-inflammatory and anti-tumor effect. The main purpose of this study was to survey the effects of PlaD on S100A8/A9-induced inflammation in mouse mammary carcinoma 4T1 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.008DOI Listing
February 2019
2 Reads

A three-dimensional microfluidized liver system to assess hepatic drug metabolism and hepatotoxicity.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Biomaterials for HealthCare@CRIB, Istituto Italiano di Tecnologia, Naples, Italy.

In this study, we propose the design and fabrication of a liver system on a chip. We first chose the most suitable three-dimensional liver-like model between cell spheroids and microtissue precursors, both based on the use of hepatocellular carcinoma cells (HepG2) to provide proof-of-concept data. Spheroids displayed high cell density but low expression of the typical hepatic biomarkers, whereas microtissue precursors showed stable viability and function over the entire culture time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bit.26902DOI Listing
December 2018
4 Reads

A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion.

Virchows Arch 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.

The renal cell carcinomas associated with Xp11 translocations (Xp11 translocation RCCs) harbor gene fusions involving TFE3, a member of the microphthalmia-associated transcription factor (MiTF) family. In the present study, we identified a novel partner of TFE3, Ewing sarcoma breakpoint region 1 (EWSR1), in an Xp11 translocation RCC. A 57-year-old Japanese woman without special disease history was referred to us for treatment of an RCC. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00428-018-2509-8
Publisher Site
http://dx.doi.org/10.1007/s00428-018-2509-8DOI Listing
December 2018
11 Reads