10,438 results match your criteria Translocation Carcinoma


Radix et Rhizoma Ginseng chemoprevents both initiation and promotion of cutaneous carcinoma by enhancing cell-mediated immunity and maintaining redox homeostasis.

J Ginseng Res 2020 Jul 21;44(4):580-592. Epub 2019 May 21.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people's physical vitality and is also a non-organ-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.jgr.2019.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322735PMC

Upregulated SET Promotes Cell Survival Through Activating Akt/NF-κB Signal in Colorectal Carcinoma.

Cancer Manag Res 2020 19;12:4735-4745. Epub 2020 Jun 19.

Department of Medical Cellular Biology and Genetics, Shanxi Medical University, Taiyuan 030001, People's Republic of China.

Purpose: SET has been proven to be an oncogene, which promotes the initiation and progression in several kinds of malignant carcinomas. However, the expression and its functional roles in colorectal carcinoma (CRC) remained unknown.

Materials And Methods: CRC tissues samples, CRC cell lines and xenograft mouse tumors were used in this study. Read More

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http://dx.doi.org/10.2147/CMAR.S255930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310974PMC

Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.

J Cell Mol Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Pharmacology, Dalian Medical University, Dalian, China.

Alcoholic liver disease (ALD) is the major cause of chronic liver disease and a global health concern. ALD pathogenesis is initiated with liver steatosis, and ALD can progress to steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma. Salvianic acid A (SAA) is a phenolic acid component of Danshen, a Chinese herbal medicine with possible hepatoprotective properties. Read More

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http://dx.doi.org/10.1111/jcmm.15473DOI Listing

The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No 639, Zhizaoju Rd, Shanghai, 200011, China.

Receptor tyrosine kinases (RTKs) and Yes-associated protein (YAP) are critical driving factors in tumors. Currently, the regulation of RTKs in the Hippo-YAP pathway has been recognized as an important issue. However, the relationship between AXL, one of the RTKs, and YAP in head and neck squamous cell carcinoma (HNSCC) remains unknown. Read More

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http://dx.doi.org/10.1111/cas.14546DOI Listing

Recurrent Amplification of the Osmotic Stress Transcription Factor in Adrenocortical Carcinoma.

J Endocr Soc 2020 Jul 25;4(7):bvaa060. Epub 2020 May 25.

Department of Surgery & Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, New Haven, Connecticut.

Tumorigenesis requires mitigation of osmotic stress and the transcription factor nuclear factor of activated T cells 5 (NFAT5) coordinates this response by inducing transcellular transport of ions and osmolytes. NFAT5 modulates in vitro behavior in several cancer types, but a potential role of NFAT5 in adrenocortical carcinoma (ACC) has not been studied. A discovery cohort of 28 ACCs was selected for analysis. Read More

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http://dx.doi.org/10.1210/jendso/bvaa060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304660PMC

The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.

Cell Death Dis 2020 Jun 25;11(6):488. Epub 2020 Jun 25.

Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Retinol-binding protein 1 (RBP1) is involved in several physiological functions, including the regulation of the metabolism and retinol transport. Studies have shown that it plays an important role in the pathogenesis of several types of cancer. However, the role of RBP1 and its correlation with autophagy in oral squamous cell carcinoma (OSCC) pathogenesis remain unknown. Read More

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http://dx.doi.org/10.1038/s41419-020-2693-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316825PMC

The mechanism of dysbiosis in alcoholic liver disease leading to liver cancer.

Hepatoma Res 2020 20;6. Epub 2020 Feb 20.

Department of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Currently, alcoholic liver disease (ALD) is one of the most prevalent chronic liver diseases worldwide, representing one of the main etiologies of cirrhosis and hepatocellular carcinoma (HCC). Although we do not know the exact mechanisms by which only a selected group of patients with ALD progress to the final stage of HCC, the role of the gut microbiota within the progression to HCC has been intensively studied in recent years. To date, we know that alcohol-induced gut dysbiosis is an important feature of ALD with important repercussions on the severity of this disease. Read More

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http://dx.doi.org/10.20517/2394-5079.2019.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313221PMC
February 2020

Higher Tumor Mutation Burden and Higher PD-L1 Activity Predicts the Efficacy of Immune Checkpoint Inhibitor Treatment in a Patient With Four Lung Cancers. A Case Report.

Front Oncol 2020 2;10:689. Epub 2020 Jun 2.

Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan.

We experienced a patient who had four lung cancers with different pathological features, with the most advanced being diagnosed as pStage IIA. A month after the resection, the original lung cancer had metastasized to the lung and to the liver. Of the original lung cancers that were resected, the biggest adenocarcinoma of S3 showed 50 × 31 × 17 mm (invasion 50 mm) and pT2bN0M0 (pStage IIA) with epidermal growth factor receptor (EGFR) mutation (-) and anaplastic lymphoma kinase (ALK) translocation (-), but expression of programmed death ligand 1 (PD-L1) (+) tumor proportion score (TPS) 80%. Read More

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http://dx.doi.org/10.3389/fonc.2020.00689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280536PMC

Taurocholic acid lowers the inflammatory response of gingival fibroblasts, epithelial cells, and macrophages.

J Oral Sci 2020 ;62(3):335-339

Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna.

Taurocholic acid (TCA), a conjugation of cholic acid with taurine, is one of the main bile acids that is elevated in liver disease. Considering the epidemiologic linkage of periodontal disease to liver disease, the question arises about the possible effect of elevated TCA levels on periodontal cells. To answer this question, gingival fibroblasts and human oral squamous cell carcinoma cell line (HSC-2) were pretreated with interleukine1β (IL1β) and tumor necrosis factorα (TNFα) in the presence and absence of TCA. Read More

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http://dx.doi.org/10.2334/josnusd.19-0342DOI Listing

UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes.

EBioMedicine 2020 Jun 20;57:102835. Epub 2020 Jun 20.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu 210042, China. Electronic address:

Background: Little is known about whether UVB can directly influence epigenetic regulatory pathways to induce cutaneous squamous cell carcinoma (CSCC). This study aimed to identify epigenetic-regulated signalling pathways through global methylation and gene expression profiling and to elucidate their function in CSCC development.

Methods: Global DNA methylation profiling by reduced representation bisulfite sequencing (RRBS) and genome-wide gene expression analysis by RNA sequencing (RNA-seq) in eight pairs of matched CSCC and adjacent normal skin tissues were used to investigate the potential candidate gene(s). Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317242PMC

TGF-β1 induces N-cadherin expression by upregulating Sox9 expression and promoting its nuclear translocation in human oral squamous cell carcinoma cells.

Oncol Lett 2020 Jul 4;20(1):474-482. Epub 2020 May 4.

Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Yahaba-cho, Iwate 028-3694, Japan.

Squamous cell carcinoma (SCC) is the most frequent cancer that develops in the oral cavity. Epithelial-mesenchymal transition (EMT) is known to play an important role in the process of metastasis of SCC cells. In our previous study, we demonstrated that TGF-β1 induced EMT in the human oral SCC (hOSCC) cell line HSC-4. Read More

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http://dx.doi.org/10.3892/ol.2020.11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285821PMC

Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells.

Prostate 2020 Jun 15. Epub 2020 Jun 15.

Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background: Recently, resveratrol (Res) has been suggested to suppress the migration and invasion of prostate cancer (PCa). In the present study, we aimed to investigate the effects of Res on genomic DNA methylation, as well as the migration and invasion of PCa cells.

Methods: The suppression by Res of the growth of PCa cells was verified through a cytotoxicity assay. Read More

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http://dx.doi.org/10.1002/pros.24029DOI Listing

Transcriptional activation of cyclin D1 via HER2/HER3 contributes to EGFR-TKI resistance in lung cancer.

Biochem Pharmacol 2020 Jun 12;178:114095. Epub 2020 Jun 12.

Groningen Research Institute of Pharmacy, Department of Chemical and Pharmaceutical Biology, University of Groningen, 9713 AV Groningen, the Netherlands. Electronic address:

Several different mechanisms are implicated in the resistance of lung cancer cells to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), and only few have been functionally investigated. Here, using genetically knocked out EGFR and TKI-resistant lung cancer cells, we show that loss of wild-type EGFR attenuates cell proliferation, migration and 3D-spheroid formation, whereas loss of mutant EGFR or resistance to TKIs reinforces those processes. Consistently, disruption of wild-type EGFR leads to suppression of HER2/HER3, while mutant EGFR ablation or resistance to TKIs increases HER2/HER3 expression, compensating for EGFR loss. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114095DOI Listing

Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma.

World J Surg Oncol 2020 Jun 13;18(1):128. Epub 2020 Jun 13.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Background: Deletions of 17p13 recurrently occur in renal cell carcinoma (RCC) but their prognostic role seems to be uncertain.

Methods: To determine prevalence, relationship with tumor phenotype, and patient prognosis, a tissue microarray containing samples from 1809 RCCs was evaluated using dual labeling fluorescence in situ hybridization (FISH) with 17p13 and chromosome 17 centromere probes.

Results: A 17p13 deletion was found in 72 of 1429 interpretable tumors. Read More

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http://dx.doi.org/10.1186/s12957-020-01902-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293794PMC

Effects of aspirin on hepatocellular carcinoma and its potential molecular mechanism.

J BUON 2020 Mar-Apr;25(2):981-986

Department of General Surgery, the third People's Hospital of Liaocheng, Liaocheng 252000, China.

Purpose: To explore the effects of aspirin (ASP) on the proliferation and apoptosis of HepG2 hepatocellular carcinoma (HCC) cells via the Wnt/β-catenin signaling pathway.

Methods: Human HCC cells were cultured and treated with ASP at different concentrations. Cell proliferation was determined with cell counting kit-8 (CCK-8) and colony formation, and the rate of apoptosis was measured by flow cytometry. Read More

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CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after γ-rays but not carbon ions irradiation.

Am J Cancer Res 2020 1;10(5):1400-1415. Epub 2020 May 1.

Institute of Radiation Medicine, Shanghai Medical College, Fudan University Shanghai, China.

Nasopharyngeal carcinoma (NPC) is a major health problem in the East and Southeast Asia, and the intensity modulated radiotherapy (IMRT) is the current preferred treatment method of NPC, but radioresistance-induced residual and recurrent tumors are the main cause of treatment failure. Till now, the mechanism of radioresistance and prognostic biomarkers of NPC are still unrevealed. In this study, we collected clinical NPC samples and established radioresistant NPC-R cell lines by irradiating NPC cells with fractionation doses of γ-rays. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269788PMC

Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.

Am J Transl Res 2020 15;12(5):1614-1639. Epub 2020 May 15.

Department of Oncology, Zhujiang Hospital, Southern Medical University 253 Industrial Avenue, Guangzhou 510282, China.

Kinesin superfamily proteins (KIFs) comprise a family of molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner, with multiple roles in cancers. Little is known about the function of KIFs in hepatocellular carcinoma (HCC). Here, we investigate the roles of KIFs in the prognosis and progression of HCC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270015PMC
May 2020
3.226 Impact Factor

MYC Expression has Limited Utility in the Distinction of Undifferentiated Radiation-associated Sarcomas from Sporadic Sarcomas and Sarcomatoid Carcinoma.

Histopathology 2020 Jun 7. Epub 2020 Jun 7.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

Aim: MYC is a proto-oncogene frequently dysregulated in various malignancies through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification and immunohistochemistry has been shown to be a reliable surrogate marker for amplification, but less is known about MYC expression in other sarcoma types despite reported MYC amplification in some undifferentiated/unclassified radiation-associated sarcomas (RAS). Distinguishing putative RAS from non-radiation-associated sarcoma or sarcomatoid carcinoma can be difficult. Read More

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http://dx.doi.org/10.1111/his.14168DOI Listing

Hypoallergenic infant formula lacks transforming growth factor beta activity and has a lower anti-inflammatory activity than regular infant formula.

J Dairy Sci 2020 Jun 3. Epub 2020 Jun 3.

Department of Oral Biology, Medical University of Vienna, Sensengasse 2a, 1090 Vienna, Austria; Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010 Bern, Switzerland; Austrian Cluster for Tissue Regeneration, Donaueschingenstraße 13, 1200 Vienna, Austria. Electronic address:

Hypoallergenic formulas are recommended for infants who are not breastfed and cannot tolerate cow milk formulas due to allergy. These formulas are hydrolyzed to break down larger protein chains into shorter, easy-to-digest, and potentially less allergenic proteins. Hydrolysis, however, possibly occurs at the expense of the transforming growth factor beta (TGF-β) and anti-inflammatory activity that is inherent in regular formula. Read More

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http://dx.doi.org/10.3168/jds.2019-18067DOI Listing

Immunohistochemical neuroendocrine marker expression in primary pulmonary NUT carcinoma: a diagnostic pitfall.

Histopathology 2020 Jun 5. Epub 2020 Jun 5.

University of Padova, Medical School, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, via N. Gustiniani, 2, 35128, Padova, Italy.

NUT carcinoma is a malignant epithelial tumour characterized by the presence of a translocation of the NUT gene (NUTM1, NUT family member 1). Primary pulmonary NUT carcinomas have been reported only in individual case reports or small case series. No pathognomonic morphological and immunohistochemical features have been described. Read More

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http://dx.doi.org/10.1111/his.14166DOI Listing

Role of Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.

Int J Mol Sci 2020 May 28;21(11). Epub 2020 May 28.

Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

Sessile serrated adenoma/polyp with dysplasia (SSA/P-D) is an SSA/P with cellular dysplasia and has a higher risk of progressing to colon carcinogenesis. Previously, we reported that tight junction impairment by enterotoxin (CPE) leads to activation of the transcriptional co-activator yes-associated protein (YAP) in oral squamous cell carcinoma. Here, we investigated whether CPE activates YAP to promote the malignant progression of SSA/P. Read More

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http://dx.doi.org/10.3390/ijms21113840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313056PMC

Conjunctival Adenosquamous Carcinoma Lacks Translocation: A Variant of Squamous Cell Carcinoma With Mucoepidermoid Differentiation and Aggressive Behavior?

Int J Surg Pathol 2020 May 31:1066896920918944. Epub 2020 May 31.

Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China.

Conjunctival adenosquamous carcinoma, also known as mucoepidermoid carcinoma (MEC), is a rare tumor that preferentially affects the perilimbal area of the conjunctiva with aggressive local invasion. Consisting of infiltrative proliferation of squamous cells and mucous cells, its morphologic features are reminiscent of the salivary gland-type MEC except for the absence of intermediate cells and frequent keratin production. We reported 2 cases of conjunctival adenosquamous carcinoma and, for the first time, studied the translocation status of this rare entity. Read More

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http://dx.doi.org/10.1177/1066896920918944DOI Listing

Soft tissue tumor with novel NR1D1-MAML1 fusion in a pediatric case.

Virchows Arch 2020 May 31. Epub 2020 May 31.

Department of Diagnostic Pathology, Hyogo Cancer Center, 13-70 Kitaooji-cho, Akashi, Hyogo Prefecture, 673-0021, Japan.

We herein describe soft tissue tumor arising in the lower extremity of a pediatric patient. The tumor displayed a unique and wide range of histological features, sheet-like and cohesive growth pattern consisting of enlarged round to epithelioid atypical cells with a large alveolar and pseudopapillary histological architecture, focally mimicking alveolar soft part sarcoma and MiT family translocation renal cell carcinoma. Tumor cells were focally immunoreactive for cytokeratin, S-100, and EMA. Read More

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http://dx.doi.org/10.1007/s00428-020-02838-0DOI Listing

The SLC Family Are Candidate Diagnostic and Prognostic Biomarkers in Clear Cell Renal Cell Carcinoma.

Biomed Res Int 2020 1;2020:1932948. Epub 2020 May 1.

Department of Urology, Shandong Province Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, Shandong 250000, China.

Clear cell renal cell carcinoma (ccRCC) is the most common lethal subtype of renal cancer, and changes in tumor metabolism play a key role in its development. Solute carriers (SLCs) are important in the transport of small molecules in humans, and defects in SLC transporters can lead to serious diseases. The expression patterns and prognostic values of SLC family transporters in the development of ccRCC are still unclear. Read More

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http://dx.doi.org/10.1155/2020/1932948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212275PMC

Prognostic significance of low expression of B-cell translocation gene 1 () in skin squamous cell carcinoma.

J Biosci 2020 ;45

Department of Clinical Laboratory, Linyi Traditional Hospital, Linyi 276003, Shandong, China.

Although the B-cell translocation gene 1 (BTG1) plays an important role in apoptosis and negatively regulates cell proliferation, BTG1 expression in skin squamous cell carcinoma (SCC) has not been reported. In this study, we wanted to investigate the significance of BTG1 expression in SCC and adjacent tissues. The expression of BTG1 protein and mRNA in SCC tissues and adjacent tissues were detected by immunohistochemistry technique (IHC), Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR). Read More

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January 2020
2.064 Impact Factor

A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction.

Ann Hematol 2020 Jul 26;99(7):1561-1564. Epub 2020 May 26.

Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.

NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of PDGFRA, which co-exists with a new nucleosome assemble protein 1-like 4 gene (NAP1L4) NAP1L4-NUTM1 fusion. Read More

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http://dx.doi.org/10.1007/s00277-020-04000-xDOI Listing

Assessing Genomic Copy Number Alterations as Best Practice for Renal Cell Neoplasia: An Evidence-Based Review from the Cancer Genomics Consortium Workgroup.

Cancer Genet 2020 Jun 1;244:40-54. Epub 2020 May 1.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, MSC 908, Charleston, SC 29425.

Renal cell neoplasia are heterogeneous with diverse histology, genetic alterations, and clinical behavior that are diagnosed mostly on morphologic features. The Renal Cell Neoplasia Workgroup of the Cancer Genomics Consortium systematically evaluated peer-reviewed literature on genomic studies of renal cell carcinoma (RCC), including clear cell RCC, papillary RCC, chromophobe RCC, and the translocation RCC involving TFE3, TFEB and MITF rearrangements, as well as benign oncocytoma, which together comprise about 95% of all renal cell neoplasia. The Workgroup curated recurrent copy number alterations (CNAs), copy-neutral loss-of-heterozygosity (cnLOH), rearrangements, and mutations, found in each subtype and assigned clinical relevance according to established criteria. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.04.004DOI Listing

Image analysis discloses differences in nuclear parameters between ERG+ and ERG- prostatic carcinomas.

Pol J Pathol 2020 ;71(1):20-29

Department of Urology, Jagiellonian University Medical College, Krakow, Poland.

Prostatic carcinoma (PC) is the most frequent urologic cancer and one of the most frequent cancers in males; it is a heterogeneous disease, in terms of molecular features, morphology and prognosis. About half of cases depends on TMPRSS2-ETS translocation which leads to a production of ERG transcription factor. ERG+ and ERG- cancers seem to differ in a number of features, which could lead to an altered nuclear structure; the aim of the study was to test this hypothesis. Read More

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http://dx.doi.org/10.5114/pjp.2020.95412DOI Listing
January 2020

Anti-Cancer Potential of in Pancreatic Cancer Cell through Regulation of the ERK/Src/STAT3-Mediated Pathway.

Molecules 2020 May 14;25(10). Epub 2020 May 14.

College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

As a plant medicine, has been used to treat various diseases in Korea. However, there is little data on the anti-cancer efficacy of , particularly . This study aimed to investigate the anti-cancer effect of methanol extract (OOE) and its regulatory actions on pancreatic carcinoma. Read More

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http://dx.doi.org/10.3390/molecules25102301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288118PMC

Sclerosing TSC1 mutated renal cell carcinoma: An unusual pattern mimicking MITF family translocation renal cell carcinoma.

Genes Chromosomes Cancer 2020 May 16. Epub 2020 May 16.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan, USA.

The tuberous sclerosis genes and MTOR are increasingly being found to have important roles in novel subtypes of renal cancer, particularly emerging entities eosinophilic solid and cystic renal cell carcinoma (RCC) and high-grade oncocytic renal tumor (HOT)/RCC with eosinophilic and vacuolated cytoplasm. We report a unique renal neoplasm in a 66-year-old woman that initially mimicked MITF family translocation RCC due to mixed clear and eosinophilic cells, extensive stromal hyalinization, and psammoma bodies, yet which was negative for TFE3 and TFEB fluorescence in situ hybridization and a next generation sequencing (NGS) gene fusion assay. Cytoplasmic stippling triggered consideration of TSC-associated neoplasms, and a targeted NGS assay revealed a variant in exon 21 of TSC1 resulting in c. Read More

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http://dx.doi.org/10.1002/gcc.22860DOI Listing

Malignant melanotic Xp11 neoplasms exhibit a clinicopathologic spectrum and gene expression profiling akin to alveolar soft part sarcoma: a proposal for reclassification.

J Pathol 2020 May 17. Epub 2020 May 17.

Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China.

The classification of the distinct group of mesenchymal neoplasms, first described as 'Xp11 translocation perivascular epithelioid cell tumor (PEComa)' and for which the term 'melanotic Xp11 neoplasm' or 'Xp11 neoplasm with melanocytic differentiation' has recently been proposed, remains challenging and controversial. We collected 27 melanotic Xp11 neoplasms, the largest series to date, for a comprehensive evaluation. Fourteen of the cases, together with eight alveolar soft part sarcomas (ASPS), nine conventional PEComas and a control group of seven normal tissues were submitted to RNA sequencing. Read More

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http://dx.doi.org/10.1002/path.5470DOI Listing

Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.

Toxicol In Vitro 2020 May 12;67:104885. Epub 2020 May 12.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China. Electronic address:

Cetuximab plus oridonin showed a synergistic way to kill laryngeal squamous cell carcinoma (LSCC), as been reported previously. The present work further mechanistically extended action of the synergistic effects of combination treatment. Firstly, two LSCC cells displayed higher sensitivity to oridonin, whereas both low EGFR expression tumor cells and EGFR knockdown LSCC cells were less sensitive to oridonin. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104885DOI Listing

Pitavastatin induces apoptosis in oral squamous cell carcinoma through activation of FOXO3a.

J Cell Mol Med 2020 Jun 14;24(12):7055-7066. Epub 2020 May 14.

College of Pharmacy, Keimyung University, Daegu, South Korea.

Statins are a class of lipid-lowering drugs that have recently been used in drug repositioning in the treatment of human cancer. However, the underlying mechanism of statin-induced cancer cell death has not been clearly defined. In the present study, we evaluated the anticancer effect of pitavastatin on oral squamous cell carcinoma (OSCC), SCC15 and SCC4 cells and found that FOXO3a might be a direct target in pitavastatin-induced cancer cell death. Read More

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http://dx.doi.org/10.1111/jcmm.15389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299721PMC

Mammary analogue secretory carcinoma: A case report.

Tunis Med 2020 Feb;98(2):168-171

Background: Mammary analogue secretory carcinoma is a rare new entity of low-grade malignant tumor of salivary glands. It shared the same histologic features and the chromosomal translocation t(12;15)(p13;q25) as secretory carcinoma of the breast.

Aim: To highlight the diagnosis approaches and the attitude of management in a case of MASC which is the first case reported in Tunisia. Read More

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February 2020

Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.

Cancer Biomark 2020 ;28(2):255-268

"CI Parhon" National Institute of Endocrinology, Bucharest, Romania.

Purpose: DNA methylation plays an important role in thyroid oncogenesis. The aim of this study was to investigate the connection between global and local DNA methylation status and to establish the levels of important DNA methylation regulators (TET family and DNMT1) in thyroid tumours: follicular adenoma-FA, papillary thyroid carcinoma-PTC (classic papillary thyroid carcinoma-cPTC and papillary thyroid carcinoma follicular variant fvPTC).

Methods: Global DNA methylation profile in thyroid tumours tissue (41 paired samples) was assessed by 5-methylcytosine and 5-hydroxymethylcytosine levels evaluation (ELISA), along with TETs and DNMT1 genes expression quantification. Read More

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http://dx.doi.org/10.3233/CBM-190871DOI Listing
January 2020

PLCε regulates metabolism and metastasis signaling via HIF-1α/MEK/ERK pathway in prostate cancer.

J Cell Physiol 2020 May 7. Epub 2020 May 7.

Laboratory Medical College, Chongqing Medical University, Chongqing, China.

Phospholipase C-ε (PLCε) is frequently overexpressed in tumors and plays an important role in the regulation of tumorigenesis. Although great progress has been made in understanding biological roles of PLCε, the relevant molecular mechanisms underlying its pro-tumor activity remain largely unclear. Here, we demonstrated that PLCε knockdown reduced cell metastasis, glucose consumption and lactate production in a manner that depended on hypoxia inducible factor 1α (HIF-1α) expression in prostate cancer cells. Read More

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http://dx.doi.org/10.1002/jcp.29698DOI Listing

TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.

Hepatology 2020 May 7. Epub 2020 May 7.

Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

How Wnt signaling is orchestrated in liver regeneration and tumorigenesis remains elusive. Recently, we identified transmembrane protein 9 (TMEM9) as a Wnt signaling amplifier. TMEM9 facilitates v-ATPase assembly for vesicular acidification and lysosomal protein degradation. Read More

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http://dx.doi.org/10.1002/hep.31305DOI Listing
May 2020
11.055 Impact Factor

Biocompatible Magnetic Micro- and Nanodevices: Fabrication of FePt Nanopropellers and Cell Transfection.

Adv Mater 2020 Jun 6;32(25):e2001114. Epub 2020 May 6.

Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, Stuttgart, 70569, Germany.

The application of nanoparticles for drug or gene delivery promises benefits in the form of single-cell-specific therapeutic and diagnostic capabilities. Many methods of cell transfection rely on unspecific means to increase the transport of genetic material into cells. Targeted transport is in principle possible with magnetically propelled micromotors, which allow responsive nanoscale actuation and delivery. Read More

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http://dx.doi.org/10.1002/adma.202001114DOI Listing

HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC‑3 cells.

Int J Mol Med 2020 Jul 28;46(1):58-66. Epub 2020 Apr 28.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930‑0194, Japan.

Hyperthermia (HT) is considered to be of value as a treatment modality in various cancers. However, the acquisition of thermotolerance in cancer cells due to the induction of heat shock proteins (HSPs) makes HT less effective. Recent findings have indicated that heat shock protein nuclear import factor hikeshi (HIKESHI), also referred to as C11orf73, acts as a nuclear import carrier of Hsp70 under heat stress conditions. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255474PMC

PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination.

Theranostics 2020 6;10(12):5322-5340. Epub 2020 Apr 6.

Peking University Third Hospital, Beijing 100191, China.

: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, with high recurrence and metastasis rates. Although radiation is an effective treatment for tumors, it is often limited by intrinsic radioresistance in HCC. The contributions of dysregulated microRNAs, including miR-31-5p, to HCC progression have been recently reported. Read More

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http://dx.doi.org/10.7150/thno.42371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196300PMC

Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways.

Anticancer Res 2020 May;40(5):2467-2474

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, U.S.A.

Background/aim: The hormonally-active form of vitamin D, 1,25(OH)D, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D and 1,20(OH)D, have overlapping beneficial effects with 1,25(OH)D without causing hypercalcemia. This study sought to determine (i) whether 20(OH)D and 1,20(OH)D exhibit antitumor effects against OSCC comparable to those of 1,25(OH)D and (ii) whether these effects may stem from down-regulation of sonic hedgehog (SHH) or WNT/β-catenin signaling pathways. Read More

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http://dx.doi.org/10.21873/anticanres.14216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241289PMC

Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives.

Front Mol Biosci 2020 15;7:60. Epub 2020 Apr 15.

Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hanover, Germany.

Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.3389/fmolb.2020.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174549PMC

Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).

PLoS One 2020 28;15(4):e0232283. Epub 2020 Apr 28.

Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.

Aim: Metabolic reprograming is crucial in the proliferation of hepatocellular carcinoma (HCC). Canagliflozin (CANA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, affects various metabolisms. We investigated the effects of CANA on proliferation and metabolic reprograming of HCC cell lines using multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232283PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188283PMC

YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.

Mol Cell Probes 2020 Apr 22:101577. Epub 2020 Apr 22.

Center of Oral Medicine, Qingdao Municipal Hospital, #5 Donghai Middle Road, Qingdao, 266000, PR China; School of Stomatology, Qingdao University; #19 JiangSu Road, Qingdao, 266000, PR China. Electronic address:

Ionizing radiation (IR) confers a survival advantage in tongue squamous cell carcinoma (TSCC), however, IR resistance limits its efficacy. Although Yin Yang 1 (YY1) has been reported to play a role in genotoxic drug resistance by accelerating DNA repair, its role in TSCC radioresistance remains unclear. In this study, we examined YY1 mRNA and protein expression in human tongue cancer samples using qRT-PCR and western blotting, respectively. Read More

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http://dx.doi.org/10.1016/j.mcp.2020.101577DOI Listing

Concurrent presence of secretory carcinoma and Warthin's tumor in ipsilateral parotid gland.

Oral Oncol 2020 Apr 21:104691. Epub 2020 Apr 21.

DeWitt Daughtry Family Department of Surgery, Division of Oral and Maxillofacial Surgery, Section of Head and Neck Surgical Oncology/, Microvascular Reconstructive Surgery, University of Miami, Miller School of Medicine/Jackson Health System, Deering Medical Plaza, 9380 SW 150(th) St #170, Miami, FL 33176, United States. Electronic address:

Background: The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland.

Methods: The patient presented with increasingly painful enlargement of the left parotid gland. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104691DOI Listing

An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients.

JNCI Cancer Spectr 2020 Apr 6;4(2):pkz094. Epub 2019 Nov 6.

Harvard Medical School, Boston, MA.

Background: NUT midline carcinoma, renamed NUT carcinoma (NC), is an aggressive squamous cancer defined by rearrangement of the gene. Although a subset of patients can be cured, for the majority of patients the prognosis is grim. We sought to classify patients into risk groups based on molecular and clinicopathologic factors at the time of diagnosis. Read More

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http://dx.doi.org/10.1093/jncics/pkz094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165803PMC

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

Nature 2020 04 8;580(7804):530-535. Epub 2020 Apr 8.

The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China.

Cancer cells increase lipogenesis for their proliferation and the activation of sterol regulatory element-binding proteins (SREBPs) has a central role in this process. SREBPs are inhibited by a complex composed of INSIG proteins, SREBP cleavage-activating protein (SCAP) and sterols in the endoplasmic reticulum. Regulation of the interaction between INSIG proteins and SCAP by sterol levels is critical for the dissociation of the SCAP-SREBP complex from the endoplasmic reticulum and the activation of SREBPs. Read More

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http://dx.doi.org/10.1038/s41586-020-2183-2DOI Listing

Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.

Int J Oncol 2020 May 20;56(5):1093-1100. Epub 2020 Feb 20.

Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara 634‑8521, Japan.

Mast cells (MCs) are present in the tumor stroma, and MCs that express the mast cell‑specific proteases tryptase and chymase (MCTC) exhibit several tumor‑related functions. It was previously reported that melanoma inhibitory activity (MIA) gene family members, including MIA, MIA2, and transport and Golgi organization protein 1 (TANGO), possess oncogenic functions in oral squamous cell carcinoma (OSCC). However, the relationships between MCTC, and clinicopathological characteristics and activation of the MIA gene family in OSCC remain unknown. Read More

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http://dx.doi.org/10.3892/ijo.2020.4996DOI Listing

Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes.

Cells 2020 Apr 17;9(4). Epub 2020 Apr 17.

Institute of Virology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibrosis. In this study, we aimed to investigate an impact of DAA treatment on the molecular changes related to HCC development and progression in hepatoma cell lines and primary human hepatocytes. Read More

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http://dx.doi.org/10.3390/cells9041003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225999PMC