9,632 results match your criteria Translocation Carcinoma


Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing

Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma.

Cancer Res Treat 2019 Apr 16. Epub 2019 Apr 16.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment of naïve Asian patients with metastatic/recurrent nccRCC.

Materials And Methods: From January 2008 to July 2017, data of treatment-naïve, metastatic/recurrent nccRCC patients, who were treated with temsirolimus according to the standard protocol, were collected. Read More

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http://www.e-crt.org/journal/view.php?doi=10.4143/crt.2018.6
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http://dx.doi.org/10.4143/crt.2018.671DOI Listing
April 2019
1 Read

Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 (): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Department of Science, University of Basilicata, 85100 Potenza, Italy.

Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. For this reason, mitochondrial carrier gene expression needs tight regulation. The human gene, encoding for the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), catalyses the electrogenic exchange of aspartate for glutamate plus a proton, thus taking part in many metabolic processes including the malate-aspartate shuttle. Read More

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http://dx.doi.org/10.3390/ijms20081888DOI Listing

Investigating the diagnostic performance of HOTTIP, PVT1, and UCA1 long noncoding RNAs as a predictive panel for the screening of colorectal cancer patients with lymph node metastasis.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, hahid Beheshti University of Medical Sciences, Tehran, Iran.

Like other noncoding RNAs (ncRNAs), dysregulation of long ncRNAs (lncRNAs) has been associated with various clinicopathological features of colorectal cancer (CRC) patients such as lymph node metastasis (LNM). Recently, three aberrant expressed oncogenic lncRNA (onco-lncRNAs), including HOXA transcript at the distal tip (HOTTIP), plasmacytoma variant translocation 1 (PVT1), and urothelial carcinoma associated 1 (UCA1) have been reported in LNM. Herein, we compared the diagnostic performance of these lncRNAs as individual biomarkers and as a discriminating panel between LNM CRC patients, nonmetastatic lymph nodes (NLN) and normal healthy subjects. Read More

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http://dx.doi.org/10.1002/jcb.28739DOI Listing
April 2019
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NUT midline carcinoma in the right orbit: a case report.

Cancer Biol Ther 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Department of Oncology , Shanghai Yangpu District Shidong Hospital , Shanghai , P.R.China.

Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare malignant tumor defined by a unique chromosomal translocation of the NUT gene on chromosome 15q14. This very rare tumor is usually located in midline structures, especially in the head and neck region. However, there have been no previous reports of NMC arising from the eyes. Read More

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https://www.tandfonline.com/doi/full/10.1080/15384047.2019.1
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http://dx.doi.org/10.1080/15384047.2019.1598761DOI Listing
April 2019
2 Reads

The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).

Anticancer Agents Med Chem 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian Medical College, Krakow. Poland.

Background: L-kynurenine, derivate of L-tryptophan, is synthetized by indoleamine 2,3-dioxygenase (IDO). The effects of L-kynurenine depend on its binding to an aryl hydrocarbon receptor (AhR).

Objective: The aim of this study was to investigate the changes within the apoptotic pathway in PANC-1 cells subjected to L-kynurenine or L-tryptophan considering the production of anti-apoptotic proteins from the IAPs and Bcl-2 family, as well as the regulation of NF-κB signaling. Read More

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http://dx.doi.org/10.2174/1871520619666190415165212DOI Listing
April 2019
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Knockdown of lncRNA LEF1-AS1 inhibited the progression of oral squamous cell carcinoma (OSCC) via Hippo signaling pathway.

Cancer Biol Ther 2019 Apr 14:1-10. Epub 2019 Apr 14.

b Division of PET/CT, Department of Radiology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , Zhejiang , China.

It is verified that long non-coding RNAs (lncRNAs) play crucial roles in various cancers. LncRNA LEF1-AS1 is a reported oncogene in colorectal cancer and glioblastoma. In this study, we unveiled that LEF1-AS1 markedly increased in oral squamous cell carcinoma (OSCC) tissues and cell lines. Read More

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https://www.tandfonline.com/doi/full/10.1080/15384047.2019.1
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http://dx.doi.org/10.1080/15384047.2019.1599671DOI Listing
April 2019
2 Reads

Distinctive mechanisms underlie the loss of SMARCB1 protein expression in renal medullary carcinoma: morphologic and molecular analysis of 20 cases.

Mod Pathol 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Renal medullary carcinoma is a rare but highly aggressive type of renal cancer occurring in patients with sickle cell trait or rarely with other hemoglobinopathies. Loss of SMARCB1 protein expression, a core subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, has emerged as a key diagnostic feature of these tumors. However, the molecular mechanism underlying this loss remains unclear. Read More

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http://dx.doi.org/10.1038/s41379-019-0273-1DOI Listing
April 2019
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Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.

Mol Cancer 2019 04 3;18(1):78. Epub 2019 Apr 3.

Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.

Background: Emerging evidence indicates that tumor cells release a large amount of exosomes loaded with cargos during tumorigenesis. Exosome secretion is a multi-step process regulated by certain related molecules. Long non-coding RNAs (lncRNAs) play an important role in hepatocellular carcinoma (HCC) progression. Read More

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http://dx.doi.org/10.1186/s12943-019-0990-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446409PMC
April 2019
3 Reads

Cytopathological Features of Secretory Carcinoma of Salivary Glands and Ancillary Techniques in Its Diagnostics: Impact of New Milan System for Reporting Salivary Gland Cytopathology.

APMIS 2019 Apr 3. Epub 2019 Apr 3.

Pathology, Fimlab Laboratories, Arvo Ylpön katu 4, 33520, Tampere, Finland.

Cytopathological Features of Secretory Carcinoma of Salivary Glands and Ancillary Techniques in Its Diagnostics: Impact of a New Milan System for Reporting Salivary Gland Cytopathology Secretory carcinoma (SC) of salivary glands is a newly described low-grade malignancy characterized by the presence of ETV6 rearrangement. Only a few cases and very small series with cytomorphology were reported so far. Six cases of fine-needle aspirations (FNA) from afterward histologically, immunohistochemically and genetically confirmed SCs were retrieved from the archives of the authors. Read More

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http://dx.doi.org/10.1111/apm.12950DOI Listing
April 2019
3 Reads

Indomethacin impairs mitochondrial dynamics by activating the PKCζ-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.

J Biol Chem 2019 Apr 2. Epub 2019 Apr 2.

Dept of Infectious Diseases & Immunology, CSIR-Indian Institute of Chemical Biology, India.

The subcellular mechanism by which non steroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse cyclooxygenase-independent effects of these drugs. Using human gastric carcinoma cells (AGSs) and a rat gastric injury model, here we report that the NSAID indomethacin activates the protein kinase C zeta (PKCζ)-p38 MAP kinase (P38)-dynamin-related protein 1 (DRP1) pathway and thereby disrupts the physiological balance of mitochondrial dynamics by promoting mitochondrial hyper-fission and dysfunction leading to apoptosis. Notably, DRP1 knockdown or SB203580-induced P38 inhibition reduced indomethacin-induced damage to AGSs. Read More

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http://dx.doi.org/10.1074/jbc.RA118.004415DOI Listing
April 2019
2 Reads

Mammary Analogue Secretory Carcinoma of the Palate: Case Report and Review of the Literature.

Case Rep Dent 2019 27;2019:7416302. Epub 2019 Feb 27.

Division of Oral & Maxillofacial Surgery, John H. Stroger Hospital of Cook County, Chicago, IL, USA.

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. Read More

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http://dx.doi.org/10.1155/2019/7416302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415289PMC
February 2019
2 Reads

RBM10-TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break-apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review.

Histopathology 2019 Mar 25. Epub 2019 Mar 25.

Departments of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.

Aims: Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to transcription factor E3 (TFE3), a member of the microphthalmia-associated transcription factor family on chromosome Xp11.2. Dual-color break-apart fluorescence in situ hybridization (FISH) is recommended to confirm histological diagnoses. Read More

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http://dx.doi.org/10.1111/his.13866DOI Listing
March 2019
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Over-expression of miR-206 decreases the Euthyrox-resistance by targeting MAP4K3 in papillary thyroid carcinoma.

Biomed Pharmacother 2019 Mar 21;114:108605. Epub 2019 Mar 21.

Department of Head & Neck Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, PR China. Electronic address:

Purpose: microRNAs (miRNAs) play a critical role in drug resistance of multiple cancers including papillary thyroid carcinoma (PTC), indicating the potential of miRNAs as chemoresistance regulators in cancer treatment. The aim of this paper is to explore the relationship between miR-206 and chemoresistance of PTC.

Methods: qRT-PCR was conducted to examine the expression of miR-206 in PTC tissues, parental and TPC-1/euthyrox. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108605DOI Listing
March 2019
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MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma.

Int J Oncol 2019 May 18;54(5):1579-1590. Epub 2019 Mar 18.

Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 10081, P.R. China.

The incidence of recurrent t(6;9) translocation of the MYB proto‑oncogene to NFIB (the gene that encodes nuclear factor 1 B‑type) in adenoid cystic carcinoma (ACC) tumour tissues is high. However, MYB [the gene that encodes transcriptional activator Myb (MYB)] overexpression is more common, indicating that MYB serves a key role in ACC. The current study aimed to investigate the role of MYB in salivary (S)ACC growth and metastasis. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4754
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http://dx.doi.org/10.3892/ijo.2019.4754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438425PMC
May 2019
7 Reads

PTEN inactivation induces epithelial-mesenchymal transition and metastasis by intranuclear translocation of β-catenin and snail/slug in non-small cell lung carcinoma cells.

Lung Cancer 2019 Apr 29;130:25-34. Epub 2019 Jan 29.

Precision Medicine Research Center, Republic of Korea; Integrated Research Center for Genome Polymorphism, Republic of Korea; Department of Microbiology, Republic of Korea. Electronic address:

Objective: Epithelial-mesenchymal transition (EMT) is the key event in distant metastasis of diverse tumors including lung cancer. Recent evidence suggests the involvement of phosphatase and tensin homolog (PTEN) in EMT phenotypes. However, the molecular mechanism of EMT induced by PTEN inactivation is not clear in lung cancer. Read More

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http://dx.doi.org/10.1016/j.lungcan.2019.01.013DOI Listing
April 2019
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TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target.

J Pathol 2019 Mar 18. Epub 2019 Mar 18.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Ten-eleven translocation methylcytosine dioxygenase-1, TET1, takes part in active DNA demethylation. However, our understanding of DNA demethylation in cancer biology and its clinical significance remain limited. This study showed that TET1 expression correlated with poor survival in advanced-stage epithelial ovarian carcinoma (EOC), and with cell migration, anchorage-independent growth, cancer stemness, and tumorigenicity. Read More

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http://dx.doi.org/10.1002/path.5266DOI Listing
March 2019
3 Reads

A novel strategy of transferring NIS protein to cells using extracellular vesicles leads to increase in iodine uptake and cytotoxicity.

Int J Nanomedicine 2019 7;14:1779-1787. Epub 2019 Mar 7.

Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea,

Background: This study was designed to explore a novel approach for transferring NIS protein to cells using extracellular vesicle (EV) and enhancing iodine avidity in hepatocellular carcinoma (HCC) cells.

Methods: We transfected the HCC cells (Huh7) with NIS gene, designated as Huh7/NIS, and isolated the EVs from them. Presence of NIS protein in EVs and EV-mediated transport of NIS protein to recipient Huh7 cells were tested using Western blotting. Read More

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http://dx.doi.org/10.2147/IJN.S189738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413815PMC
March 2019
2 Reads

Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma.

Oncogene 2019 Mar 11. Epub 2019 Mar 11.

Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

The myeloid translocation gene family member MTG16 is a transcriptional corepressor that relies on the DNA-binding ability of other proteins to determine specificity. One such protein is the ZBTB family member Kaiso, and the MTG16:Kaiso interaction is necessary for repression of Kaiso target genes, such as matrix metalloproteinase-7. Using the azoxymethane and dextran sodium sulfate (AOM/DSS) murine model of colitis-associated carcinoma, we previously determined that MTG16 loss accelerates tumorigenesis and inflammation. Read More

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http://dx.doi.org/10.1038/s41388-019-0777-7DOI Listing
March 2019
2 Reads

Analysis of clinicopathological characteristics, rearrangement and prognostic factors in salivary adenoid cystic carcinoma.

Oncol Lett 2019 Mar 15;17(3):2915-2922. Epub 2019 Jan 15.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.

Recent studies have indicated that a recurrent t(6;9)(q22-23;p23-24) chromosomal translocation in salivary adenoid cystic carcinoma (ACC) results in a MYB proto-oncogene transcription factor-nuclear factor I/B gene fusion, which has not previously been detected in any non-ACC carcinomas of the head and neck. In the present study, data on clinical factors affecting the survival rate of patients with salivary ACC from a single institution was retrospectively analyzed, and the frequency of gene rearrangement determined. A total of 97 patient cases were analyzed, and young adults presenting with ACC (<40 years old) accounted for 19. Read More

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http://dx.doi.org/10.3892/ol.2019.9935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365922PMC

Metformin-activated AMPK regulates β-catenin to reduce cell proliferation in colon carcinoma RKO cells.

Oncol Lett 2019 Mar 4;17(3):2695-2702. Epub 2019 Jan 4.

Department of Microbiology, College of Medicine, Korea University, Seoul 136-705, Republic of Korea.

Metformin can suppress cell proliferation and viability by altering mitochondrial energy metabolism and by the activation of 5'-adenosine monophosphate-activated protein kinase (AMPK). The current study demonstrated that metformin-induced suppression of cell proliferation is further potentiated by AMPK-mediated suppression of β-catenin-dependent wingless-type (Wnt) signaling. Treatment with metformin reduced mitochondrial oxidative phosphorylation and glycolysis, leading to an energy imbalance that may induce AMPK phosphorylation in RKO cells. Read More

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http://dx.doi.org/10.3892/ol.2019.9892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365932PMC
March 2019
1 Read

Annexin A2 interacting with ELMO1 regulates HCC chemotaxis and metastasis.

Life Sci 2019 Apr 7;222:168-174. Epub 2019 Mar 7.

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:

Aims: SDF-1α induced chemotaxis plays an important role in hepatocellular carcinoma metastasis. CXCR4 stimulated by SDF-1α/CXCL12 triggers heterotrimeric G proteins activation, which regulate migration and chemotaxis of hepatocellular carcinoma cells. The pathways linking the chemokine GPCR/Gi signaling to actin polymerization for migration of cancer cells are not known. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193015
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http://dx.doi.org/10.1016/j.lfs.2019.03.003DOI Listing
April 2019
5 Reads

A 47-year-old woman with nuclear protein in testis midline carcinoma masquerading as a sinus infection: a case report and review of the literature.

J Med Case Rep 2019 Mar 11;13(1):57. Epub 2019 Mar 11.

Department of Radiation Oncology, 986861 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE, 68198-686, USA.

Background: Nuclear protein in testis midline carcinoma is a rare, highly metastatic undifferentiated carcinoma that typically arises in midline structures and is characterized by having a fusion involving the nuclear protein in testis, NUT, gene. Nuclear protein in testis midline carcinoma has been identified in patients of all ages and is often initially misdiagnosed due to the rapid timeline of symptom onset.

Case Presentation: Here we report the case of a 47-year-old Caucasian woman with a nuclear protein in testis midline carcinoma that was initially mistaken for a sinus infection. Read More

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http://dx.doi.org/10.1186/s13256-019-2015-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410502PMC
March 2019
1 Read

Secretory carcinoma of the breast: A case report.

Int J Surg Case Rep 2019 28;56:74-77. Epub 2019 Feb 28.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Czech Republic; Bioptic Laboratory, Ltd., Plzen, Czech Republic.

Introduction: Secretory breast carcinoma (SBC) is a rare breast tumor which accounts for < 0.15% of all breast cancers. It was originally described as a juvenile breast carcinoma, occurring in young children and adolescent women. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407075PMC
February 2019
2 Reads

Immunohistochemistry for TFE3 lacks specificity and sensitivity in the diagnosis of TFE3-rearranged neoplasms: a comparative, two-laboratory study.

Hum Pathol 2019 Mar 6. Epub 2019 Mar 6.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:

TFE3 rearrangements are characteristic of alveolar soft part sarcomas (ASPS), Xp11.2 translocation renal cell carcinomas (Xp11-RCC), and other rare tumors. Immunohistochemistry for TFE3 protein has been considered by some to be a reliable surrogate for TFE3 molecular studies, although others disagree. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.008DOI Listing
March 2019
2 Reads

TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas.

J Exp Clin Cancer Res 2019 Mar 8;38(1):119. Epub 2019 Mar 8.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, 210093, Jiangsu, China.

Background: Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. Read More

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http://dx.doi.org/10.1186/s13046-019-1101-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408813PMC
March 2019
2 Reads

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors.

J Control Release 2019 Mar 4;301:28-41. Epub 2019 Mar 4.

Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan; Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Nanomedicine modification with ligands directed to receptors on tumor blood vessels has the potential for selectively enhancing nanomedicine accumulation in malignant tissues by overcoming the vascular barrier of tumors. Nevertheless, the development of broadly applicable ligand approaches capable of promoting the transvascular transport of nanomedicines in a wide spectrum of tumors has been elusive so far. By considering the indispensable and persistent glycolytic fueling of tumors, we developed glucose-installed polymeric micelles loading cisplatin (Gluc-CDDP/m) targeting the glucose transporter 1 (GLUT1), which is overexpressed in most tumors and present on vascular endothelial cells, toward improving the delivery efficiency and therapeutic efficacy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.021DOI Listing
March 2019
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SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.

Cell Signal 2019 Mar 4;59:1-12. Epub 2019 Mar 4.

Collaborative Research Center, Shanghai University of Medicine and Health Sciences, Shanghai, China; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China. Electronic address:

Human SLFN5 inhibits invasions of IFNα-sensitive renal clear-cell carcinoma and melanoma cells. However, whether this inhibition is confined to these IFNα-sensitive cancers is unclear. Here we show that SLFN5 expressions on both mRNA and protein levels are significantly higher in non/low-invasive cancer cell lines (breast cancer cell line MCF7, colorectal cancer cell line HCT116 and lung cancer cell line A549) than in highly-invasive cancer cell lines (fibrosarcoma cell line HT1080 and renal clear cell cancer cell line 786-0). Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.03.004DOI Listing

RASSF10 suppresses lung cancer proliferation and invasion by decreasing the level of phosphorylated LRP6.

Mol Carcinog 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, People's Republic of China.

Ras-association domain family (RASSF) proteins exert distinct cellular functions. The expression of RASSF10 in non-small cell lung cancer and its underlying mechanism have not been reported. Herein, we explored the roles of RASSF10 in lung cancer cells and potential molecular mechanisms. Read More

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http://dx.doi.org/10.1002/mc.23000DOI Listing
March 2019
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NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.

Sci Rep 2019 Mar 4;9(1):3369. Epub 2019 Mar 4.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States.

The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including in hepatocellular carcinoma (HCC), strategies have been developed on the basis of MYC amplification or gene translocation. Due to the failure of these strategies to provide accurate diagnostics and prognostic value, we have developed a Negative Elongation Factor E (NELFE)-Dependent MYC Target (NDMT) gene signature. Read More

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http://www.nature.com/articles/s41598-019-39727-9
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http://dx.doi.org/10.1038/s41598-019-39727-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399236PMC
March 2019
6 Reads

NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6.

Cell Death Dis 2019 Mar 4;10(3):217. Epub 2019 Mar 4.

Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, P.R. China.

Accumulating evidence from clinical and epidemiological studies has highlighted the close correlation between the individual risk of cancer and nervous system diseases. The expression of neuronal pentraxin 2 (NPTX2) is absent in Alzheimer's disease, anxiety, and depression. Herein, we found that NPTX2 mRNA and protein expression was significantly upregulated in colorectal carcinoma (CRC). Read More

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http://dx.doi.org/10.1038/s41419-019-1467-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399240PMC
March 2019
2 Reads

Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study.

Lancet Oncol 2019 Apr 28;20(4):581-590. Epub 2019 Feb 28.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Cabozantinib is approved for patients with metastatic renal cell carcinoma on the basis of studies done in clear-cell histology. The activity of cabozantinib in patients with non-clear-cell renal cell carcinoma is poorly characterised. We sought to analyse the antitumour activity and toxicity of cabozantinib in advanced non-clear-cell renal cell carcinoma. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30907-0DOI Listing
April 2019
3 Reads

Factors related to lymph node sampling at the time of surgery in children, adolescents, and young adults with unilateral non-metastatic renal cell carcinoma.

J Pediatr Urol 2019 Feb 1. Epub 2019 Feb 1.

University of Colorado, Department of Surgery, Division of Urology, Children's Hospital of Colorado, Aurora, CO, USA. Electronic address:

Introduction: Renal cell carcinoma (RCC) is rare in the pediatric, adolescent, and young adult (PAYA) population. PAYA patients with RCC have a high rate of lymph node (LN) involvement, regardless of primary tumor size, yet data to guide surgical LN management in this group are limited.

Objective: The objective of this study was to determine what factors are associated with LN sampling (protocol adherence) in PAYAs with RCC. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.01.009DOI Listing
February 2019
2 Reads

A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices.

Nutrients 2019 Feb 27;11(3). Epub 2019 Feb 27.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9712VM Groningen, The Netherlands.

Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder closely related to metabolic syndrome. NAFLD can progress to an inflammatory state called non-alcoholic steatohepatitis (NASH), which may result in the development of fibrosis and hepatocellular carcinoma. To develop therapeutic strategies against NAFLD, a better understanding of the molecular mechanism is needed. Read More

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http://dx.doi.org/10.3390/nu11030507DOI Listing
February 2019
4 Reads

Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells.

Int J Mol Sci 2019 Feb 26;20(5). Epub 2019 Feb 26.

Department of Internal Medicine, Fujikawa Hospital, 1-2-6 Matsubara, Saga 840-0831, Japan.

Hypoxia-inducible factor 1 (HIF-1) plays important roles in cancer cell biology. HIF-1α is reportedly activated by several factors, including protein kinase C (PKC), in addition to hypoxia. We investigated the role of PKC isoforms and the effects of vitamin K2 (VK2) in the activation process of HIF-1α. Read More

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http://www.mdpi.com/1422-0067/20/5/1022
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http://dx.doi.org/10.3390/ijms20051022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429062PMC
February 2019
5 Reads

Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma.

Front Med (Lausanne) 2019 12;6:22. Epub 2019 Feb 12.

Centre for Advanced Imaging (CAI), The University of Queensland, Brisbane, QLD, Australia.

Squamous cell carcinoma (SCC) accounts for the majority of non-melanoma skin cancer related deaths, particularly in immunosuppressed persons. Identification of biomarkers that could be used to identify or treat SCC would be of significant benefit. The anthrax toxin receptors, Tumor Endothelial Marker 8 (TEM8) and Capillary Morphogenesis Gene 2 (CMG2), are endothelial receptors involved in extracellular matrix homeostasis and angiogenesis that are selectively upregulated on numerous tumors. Read More

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http://dx.doi.org/10.3389/fmed.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379334PMC
February 2019
1 Read

SerpinB2 is involved in cellular response upon UV irradiation.

Sci Rep 2019 Feb 26;9(1):2753. Epub 2019 Feb 26.

Department of Biochemistry and Molecular Biology, University of Szeged, Faculty of Science and Informatics, Szeged, Hungary.

Ultraviolet light induced pyrimidine dimer is a helix distortion DNA damage type, which recruits repair complexes. However, proteins of these complexes that take part in both DNA damage recognition and repair have been well-described, the regulation of the downstream steps of nucleotide excision repair (NER) have not been clearly clarified yet. In a high-throughput screen, we identified SerpinB2 (SPB2) as one of the most dramatically upregulated gene in keratinocytes following UV irradiation. Read More

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http://dx.doi.org/10.1038/s41598-019-39073-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391458PMC
February 2019
1 Read

β-Hydroxy-β-methylbutyrate Suppresses NF-ĸB Activation and IL-6 Production in TE-1 Cancer Cells.

In Vivo 2019 Mar-Apr;33(2):353-358

Department of Doctoral Program in Health Science, Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Japan.

Background/aim: Stress reactions, especially those related to surgery, cause poor convalescence of cancer patients. β-Hydroxyβ-methylbutyrate (HMB) is known to regulate excessive inflammation in the body. The objective of this work was to investigate the capacity of HMB to suppress activation of nuclear factor-kappa B (NF-ĸB) and production of interleukin-6 (IL-6) in a human esophageal squamous cell carcinoma cell line (TE-1). Read More

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http://dx.doi.org/10.21873/invivo.11481DOI Listing
December 2018
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Astaxanthin Combine With Human Serum Albumin To Abrogate Cell Proliferation, Migration, And Drug-Resistant In Human Ovarian Carcinoma SKOV3 Cells.

Anticancer Agents Med Chem 2019 Feb 25. Epub 2019 Feb 25.

Youjiang Medical University for Nationalities, 98 Chengxiang Road, Baise 533000. China.

Background: Astaxanthin (AST) shows a large range of beneficial effects together with anti-cancer and antioxidation properties. Human serum albumin (HSA) is the most abundant protein in blood plasma which plays the role of depot and transport protein for many exogenous compounds. However, whether HSA could enhance AST-induced cytotoxic effects in human ovarian cancer cells has not been examined to date. Read More

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http://dx.doi.org/10.2174/1871520619666190225123003DOI Listing
February 2019
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Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.

Gene 2019 May 20;697:94-102. Epub 2019 Feb 20.

Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China. Electronic address:

The pathogenesis and the underlying mechanisms of hepatocellular carcinoma (HCC) remain unclear. LncRNA plasmacytoma variant translocation 1 (PVT1) is an oncogene in a variety of cancers. The role of PVT1 in HCC progression is not completely understood. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.036DOI Listing
May 2019
4 Reads

Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β-catenin/TCF/LEF signalling.

Cell Prolif 2019 Feb 22:e12583. Epub 2019 Feb 22.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Objectives: Wnt1-inducible signalling pathway protein 3 (WISP3/CCN6) belongs to the CCN (CYR61/CTGF/NOV) family of proteins, dysregulation of this family contributed to the tumorigenicity of various tumours. In this study, we need to explore its role in hepatocellular carcinoma that remains largely elusive.

Materials And Methods: The expression of WISP3/CCN6 was analysed by qRT-PCR and Western blotting. Read More

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http://dx.doi.org/10.1111/cpr.12583DOI Listing
February 2019
2 Reads
3.116 Impact Factor

Xp11.2 translocation/TFE3 gene fusion renal cell carcinoma with a micropapillary pattern: cases report and literature review.

Am J Transl Res 2019 15;11(1):327-339. Epub 2019 Jan 15.

Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College Bengbu, Anhui, China.

Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion renal cell carcinoma (Xp11.2 translocation RCC) was first classified as a distinct type of renal tumor by the World Health Organization in 2004. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357303PMC
January 2019
2 Reads

Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.

Cancer Gene Ther 2019 Feb 21. Epub 2019 Feb 21.

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

COMMD10, a member of COMMD protein, has been proved to target p65 NF-kappaB (nuclear factor-kappaB) subunit and reduce its nuclear translocation, thereby leading to the inactivation of NF-kappaB pathway and suppression of colorectal cancer invasion and metastasis. The aim of this study is to explore its expression pattern and tissue distribution in human normal tissues and other tumor tissues and to investigate the relevant mechanism. We firstly provided the expression profile and histological distribution of COMMD10 in various BALB/c mice tissues and identified the biological distribution of COMMD10 in different kinds of human normal and tumor tissues. Read More

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http://dx.doi.org/10.1038/s41417-019-0087-9DOI Listing
February 2019
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The incidence of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in Saudi adult patients with renal cancer: a retrospective tissue microarray analysis.

Pol J Pathol 2018;69(4):376-383

Renal cell carcinoma (RCC) is the most common renal tumour. RCC with Xp11.2 translocation/TFE3 (transcription factor E3) gene fusions (Xp11. Read More

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http://dx.doi.org/10.5114/pjp.2018.81697DOI Listing
January 2018
2 Reads

Kindlin-2 links mechano-environment to proline synthesis and tumor growth.

Nat Commun 2019 02 19;10(1):845. Epub 2019 Feb 19.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15261, USA.

Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitochondria and its interaction with PYCR1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell proliferation. Read More

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http://dx.doi.org/10.1038/s41467-019-08772-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381112PMC
February 2019
2 Reads

Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.

Eur J Med Chem 2019 Apr 7;167:187-199. Epub 2019 Feb 7.

School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China. Electronic address:

To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2), and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect. Combining the data of cytotoxicity, cytocompatibility and anti-inflammatory activity, 3-pyridyl and -CF substituted 67 may be the potential anti-hepatoma agent. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.020DOI Listing
April 2019
5 Reads

MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.

Carcinogenesis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen Pauwelsstrasse, Germany.

In Western countries, a rising incidence of obesity and type 2 diabetes correlates with an increase of non-alcoholic steatohepatitis (NASH)-a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). NASH is associated with chronic liver injury, triggering hepatocyte death and enhanced translocation of intestinal bacteria, leading to persistent liver inflammation through activation of Toll-like receptors and their adapter protein myeloid differentiation factor 88 (MyD88). Therefore, we investigated the role of MyD88 during progression from NASH to HCC using a mouse model of chronic liver injury (hepatocyte-specific deletion of nuclear factor κB essential modulator, Nemo; NemoΔhepa). Read More

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http://dx.doi.org/10.1093/carcin/bgy173DOI Listing
February 2019
2 Reads

Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation.

EBioMedicine 2019 Mar 11;41:175-184. Epub 2019 Feb 11.

University of Michigan, Biointerfaces Institute, Ann Arbor, MI, United States; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, Ann Arbor, MI, United States. Electronic address:

Background: Patient-derived xenograft (PDX) models have significantly enhanced cancer research, and often serve as a robust model. However, enhanced growth rate and altered pathological phenotype with serial passages have repeatedly been shown in adenoid cystic carcinoma (ACC) PDX tumors, which is a major concern.

Methods: We evaluated the fidelity of ACCs in their natural habitat by performing ACC orthotopic xenotransplantation (PDOX) in salivary glands. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442226PMC
March 2019
2 Reads

Two new compounds of Penicillium polonicum, an endophytic fungus from Camptotheca acuminata Decne.

Nat Prod Res 2019 Feb 13:1-5. Epub 2019 Feb 13.

a School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan , China.

To discover novel structural compounds which are producted by endophytic fungi, a primary chemical profiling of Camptotheca acuminata Decne derived endophytic fungus Penicillum polonicum had been taken. Two new compounds β-lactone polonicin A (1) and enoic acid polonicin B (2) together with seven known compounds 3-9 were isolated from Penicillum polonicum obtained from C. acuminata. Read More

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http://dx.doi.org/10.1080/14786419.2019.1569003DOI Listing
February 2019
2 Reads
0.919 Impact Factor

Oncolytic activity of canine distemper virus in canine mammary tubular adenocarcinoma cells.

Vet Comp Oncol 2019 Feb 12. Epub 2019 Feb 12.

The Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, P.R. China.

Canine distemper virus (CDV), bearing a close resemblance to measles virus, represents a promising candidate for oncolytic therapy; however, its application and underlying oncolytic mechanisms in canine mammary carcinoma cells remain to be explored. Here, we found that an attenuated canine distemper vaccine strain, CDV-L, efficiently infected and inhibited the growth of canine mammary tubular adenocarcinoma CIPp cells but not MDCK cells in vitro. Transcriptomic analysis of CDV-L-infected CIPp cells revealed substantially differentially expressed genes in apoptotic and NF-κB signalling pathways. Read More

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http://dx.doi.org/10.1111/vco.12466DOI Listing
February 2019
3 Reads