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Diagn Interv Radiol 2022 Jun 22. Epub 2022 Jun 22.

Diagnostic and Interventional Radiology, Saarland University Medical Center, Hamburg, Germany.

To report on complication management in a 58-year-old woman referred for transjugular biopsy for evaluation of an unknown liver disease. After an initial uneventful biopsy procedure, the patient complained of severe upper abdominal pain. Laboratory test revealed increasing liver enzymes. Read More

World J Hepatol 2022 May;14(5):1038-1046

Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague 14021, Czech Republic.

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a method used to decrease portal hypertension. Biliary stricture is the rarest of the complications associated with this procedure with only 12 cases previously reported in the literature. None of these cases have documented the resolution of biliary stenosis induced by a stent graft. Read More

Cureus 2022 May 4;14(5):e24726. Epub 2022 May 4.

Pediatric Gastroenterology, Rutgers University New Jersey Medical School, Newark, USA.

Objectives To present a nationwide retrospective analysis of the sequelae and aftereffects of different liver biopsy methods in the care of pediatric patients with biliary atresia. Methods The National Inpatient Sample 2001-2013 database was queried for a primary diagnosis of biliary atresia and stratified based on biopsy type including percutaneous, surgical, laparoscopic, and transjugular. Patient demographics, length of stay, hospital costs, type of treatment, and mortality were compared by biopsy type. Read More

World J Gastrointest Oncol 2022 May;14(5):1050-1056

The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China.

Background: Primary hepatic angiosarcoma (PHA) is a rare malignancy with a poor prognosis. It is difficult to diagnose PHA because of the lack of specific symptoms or tumour markers, and it rapidly progresses and has a high mortality. To our knowledge, PHA has not been reported to mimic hepatic sinusoidal obstruction syndrome. Read More

JHEP Rep 2022 Jun 4;4(6):100482. Epub 2022 Apr 4.

Institute for Research in Biomedicine (IRB Barcelona) and The Barcelona Institute of Science and Technology. Barcelona, Catalonia, Spain.

Background & Aims: The molecular mechanisms driving the progression from early-chronic liver disease (CLD) to cirrhosis and, finally, acute-on-chronic liver failure (ACLF) are largely unknown. Our aim was to develop a protein network-based approach to investigate molecular pathways driving progression from early-CLD to ACLF.

Methods: Transcriptome analysis was performed on liver biopsies from patients at different liver disease stages, including fibrosis, compensated cirrhosis, decompensated cirrhosis and ACLF, and control healthy livers. Read More

Lancet Infect Dis 2022 Apr 29. Epub 2022 Apr 29.

Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Bacillary peliosis hepatis is a well recognised manifestation of disseminated Bartonella henselae infection that can occur in immunocompromised individuals. Haemophagocytic lymphohistiocytosis is an immune-mediated condition with features that can overlap with a severe primary infection such as disseminated Bartonella spp infection. We report a case of bacillary peliosis hepatis and secondary haemophagocytic lymphohistiocytosis due to disseminated Bartonella spp infection in a kidney-transplant recipient with well controlled HIV. Read More

Clin Infect Pract 2022 Jul 26;15:100144. Epub 2022 Apr 26.

Department of Clinical, Surgical, Diagnostic and Pediatric sciences, University of Pavia, Italy.

Background: Sars-CoV2 can cause severe pneumonia and acute respiratory distress syndrome (ARDS). In COVID-19-associated respiratory failure, lung transplantation might be an option (Bharat A).

Case Report: A previously healthy 63-year-old man with a nasopharyngeal swab positive for SarsCoV2 and radiological evidence of interstitial lung consolidations developed acute respiratory distress that required intubation and veno-venous extracorporeal membrane oxygenation support (VV ECMO). Read More

Zhonghua Gan Zang Bing Za Zhi 2022 Feb;30(2):220-223

Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

To investigate the practicability and safety of transjugular liver biopsy (TJLB). Data of 53 cases with transjugular liver biopsy from June 2015 to June 2020 were collected. LABS-100 was used in all patients who underwent transjugular liver biopsy. Read More

Radiology 2022 06 15;303(3):720-721. Epub 2022 Mar 15.

From the Abdominal and Emergency Radiology Divisions, Department of Radiology, University of Kentucky, 800 Rose St, HX 315, Lexington, KY 40536.

Curr Opin Gastroenterol 2022 05 11;38(3):216-220. Epub 2022 Mar 11.

Digestive Disease Research Center, Medical University of South Carolina, Charleston, South Carolina, USA.

Purpose Of Review: This article discusses the most recent studies regarding the emerging field of endohepatology - the use of diagnostic and therapeutic endoscopic tools for the management of patients with liver disease and portal hypertension.

Recent Findings: New research has shown that liver biopsy specimens obtained by each Endoscopic ultrasound (EUS)-guidance, the percutaneous approach, and the transjugular approach contained sufficient portal triads to adequately analyzed by experienced pathologists - suggesting that any of these routes of liver biopsy is clinically acceptable; further, all had similar rates of adverse events. An initial prospective study showed that EUS guided portal pressure measurement was safe, effective, and accurate. Read More

BMC Gastroenterol 2022 Mar 3;22(1):96. Epub 2022 Mar 3.

Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Portal hypertensive biliopathy (PHB) was caused by anatomical and functional abnormalities in the intrahepatic and extrahepatic bile ducts secondary to portal hypertension. Currently, there is no consensus regarding to the optimal treatment for PHB. Transjugular intrahepatic portosystemic shunt (TIPS) is the treatment choice for the management of symptomatic PHB, however, it could be very difficult in patients with PHB and cavernous transformation of portal vein. Read More

Cureus 2022 Jan 27;14(1):e21676. Epub 2022 Jan 27.

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, IND.

Primary biliary cholangitis (PBC), a chronic, autoimmune, cholestatic disease, typically occurs in elderly women and commonly presents with pruritus, fatigue, and cholestasis and its complications. Gastric antral vascular ectasia (GAVE), an uncommon cause of upper gastrointestinal bleeding, leading to transfusion-dependent chronic iron deficiency anemia, as the first presentation of PBC is unusual. We present the case of an elderly female with recurrent melena and transfusion-dependent anemia for a year without any history of jaundice, ascites, or hepatic encephalopathy. Read More

Semin Intervent Radiol 2022 Feb 18;39(1):103-106. Epub 2022 Feb 18.

Department of Radiology, University of Illinois College of Medicine, Chicago, Illinois.

Cardiovasc Intervent Radiol 2022 May 15;45(5):582-589. Epub 2022 Feb 15.

Department of Internal Medicine / Hepatology, Federal Hospital of Bonsucesso, Rio de Janeiro, Brazil.

Purpose: To evaluate liver function improvement and volume gain after percutaneous recanalization of chronic portal vein thrombosis (PVT) in non-cirrhotic patients.

Materials And Methods: In this retrospective study, five non-cirrhotic participants between 21 and 67 years old with secondary chronic PVT (4-21 years from diagnose) were submitted to percutaneous portal vein recanalization, followed by varices and shunts embolization.

Results: After a mean of 12. Read More

Curr Opin Organ Transplant 2022 04;27(2):144-147

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Purpose Of Review: Portomesenteric thrombosis (PMT) is a serious condition encountered mainly in cirrhotic patients awaiting liver transplantation. More recently, this potentially fatal complication has been described after bariatric surgery and inflammatory bowel disease. Several consensus guidelines have been published over the past few years and this mini review was conducted to discuss updated nontransplant treatment options based on currently available evidence. Read More

Indian J Radiol Imaging 2021 Oct 10;31(4):917-932. Epub 2022 Jan 10.

Department of Diagnostic and Interventional Radiology, Medanta-The Medicity, Gurugram, Haryana, India.

Portal hypertension is a complication of chronic liver disease. Various radiological interventions are being done to aid in the diagnosis of portal hypertension; further, an interventional radiologist can offer various treatments for the complications of portal hypertension. Diagnosis of portal hypertension in its early stage may require hepatic venous pressure gradient measurement. Read More

Hepatology 2022 Jun 13;75(6):1667-1668. Epub 2022 Mar 13.

Division of Transplant and Advanced Hepatobiliary Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

J Clin Exp Hepatol 2022 Jan-Feb;12(1):230-231. Epub 2021 Oct 28.

BLK Institute of Digestive and Liver Diseases, BLK Hospital, New Delhi, India.

J Clin Exp Hepatol 2022 Jan-Feb;12(1):80-88. Epub 2021 Apr 2.

Asian Institute of Gastroenterology, Hyderabad, India.

Background: Haematopoietic stem cell (HSC) infusion has demonstrated short-term improvement in liver functions in patients with chronic liver disease. The combination of HSC with mesenchymal stem cells (MSCs), which has an immunomodulatory effect, may augment the effects and enhance the duration of improvements on liver functions. The aim of the present study was to assess the safety of infusing the combination of autologous HSCs and MSCs in decompensated liver cirrhosis. Read More

Gut 2022 01 20. Epub 2022 Jan 20.

Department of Biomedicine, Liver Immunology, University Hospital Basel and University of Basel, Basel, Switzerland

Objective: Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert regulatory and antimicrobial functions and are implicated in liver fibrogenesis. Read More

Eur J Clin Invest 2022 Jun 26;52(6):e13750. Epub 2022 Jan 26.

UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.

Background And Aims: To evaluate two-dimensional shear wave elastography (2DSWE) in parallel with transient elastography (TE) for diagnosing clinically significant portal hypertension (CSPH) and high-risk varices (HRV) in patients with chronic liver disease.

Patients And Methods: Consecutive patients with suspicion of compensated advanced chronic liver disease (cACLD) [liver stiffness measurement (LSM) ≥ 10 kPa by TE, or morphological signs suggestive of cACLD on imaging], with no history of liver decompensation, underwent hepatic venous pressure gradient (HVPG) measurement, transjugular liver biopsy and esophagogastroduodenoscopy, which served as the reference methods for diagnosing CSPH, cACLD and HRV. All patients underwent LSM and spleen stiffness measurements (SSM) by 2DSWE and TE. Read More

Clin J Gastroenterol 2022 Apr 17;15(2):433-440. Epub 2022 Jan 17.

Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

Introduction: Various therapies and drugs have been developed to extend the life expectancy of patients with liver cirrhosis. The prolonged prognosis of cirrhotic patients may change the final cause of death in the future. Deep bleeding into the muscle is an uncommon but potentially life-threatening complication of liver cirrhosis. Read More

J Emerg Med 2022 Jan 12. Epub 2022 Jan 12.

Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Hemorrhagic cholecystitis is a rare cause of abdominal pain. Most often described in the setting of blunt abdominal trauma, anticoagulation use, coagulopathy (such as cirrhosis or renal failure), and malignancy (biliary angiosarcoma), this rare condition can be difficult to identify unless high on the differential. With point-of-care ultrasound becoming more commonplace in the emergency department (ED), this tool can be successfully used to make a timely diagnosis in the correct clinical context. Read More

Abdom Radiol (NY) 2022 03 12;47(3):1177-1186. Epub 2022 Jan 12.

Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: To compare the safety and outcome of transjugular versus percutaneous technique in recanalization of non-cirrhotic, non-malignant portal vein thrombosis.

Methods: We present a retrospective bicentric analysis of 21 patients with non-cirrhotic, non-malignant PVT, who were treated between 2016 and 2021 by interventional recanalization via different access routes (percutaneous [PT] vs. transjugular in transhepatic portosystemic shunt [TIPS] technique). Read More

J Clin Gastroenterol 2022 Jan 10. Epub 2022 Jan 10.

Division of Gastroenterology, Hepatology, and Nutrition Department of Biostatistics Division of Interventional Radiology, Virginia Commonwealth University Division of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Richmond, VA Section of Digestive Diseases, Yale University, New Haven, CT.

Background: Liver biopsy and hepatic venous pressure gradient (HVPG), the gold standard for assessing advanced fibrosis (AF) and clinically significant portal hypertension (CSPH), are invasive, costly, and time-consuming.

Goal: We investigated if the combination of fibrosis index based on 4 factors (FIB-4) and liver stiffness measure (LSM) can identify AF and more importantly, CSPH.

Patients And Methods: Patients with chronic liver disease referred for transjugular liver biopsy were analyzed retrospectively. Read More

Ann Diagn Pathol 2022 Feb 13;56:151876. Epub 2021 Dec 13.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

Purpose: Patients with end-stage heart failure and concomitant irreversible liver injury may be candidates for combined heart liver transplant (CHLT). Determining appropriate candidates for CHLT is essential given organ scarcity. Transjugular liver biopsy (TJLB) is used to evaluate the severity of parenchymal liver injury in transplant candidates. Read More

Cureus 2021 Nov 14;13(11):e19555. Epub 2021 Nov 14.

Gastroenterology and Hepatology, Saiseikai Niigata Hospital, Niigata, JPN.

Introduction Transjugular liver biopsy (TJLB) is indicated for patients in whom percutaneous liver biopsy is contraindicated, such as those with hematological diseases complicated by liver dysfunction. However, the clinical utility of TJLB in this group of patients has not been thoroughly investigated. The objective of this study is to evaluate the clinical efficacy of TJLB in patients with hematological diseases complicated by liver dysfunction. Read More

Tech Vasc Interv Radiol 2021 Dec 13;24(4):100795. Epub 2021 Nov 13.

Dotter Interventional Institute, Oregon Health Sciences University, Portland, OR.

Transjugular liver biopsy (TJLB) was first performed in 1970 and has since become a standard procedure in interventional radiology practices. TJLB can be used when a percutaneous liver biopsy is contraindicated, such as patients with ascites, coagulopathy, congenital clotting disorders or for patients undergoing concurrent evaluation for portal hypertension. While TJLB specimens tend to be smaller with less complete portal triads numerous studies have shown the samples to be adequate for diagnosis and staging. Read More

Zhonghua Gan Zang Bing Za Zhi 2020 Dec;28(12):999-1007

J Dig Dis 2021 Dec 8;22(12):727-730. Epub 2021 Dec 8.

Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.