3,177 results match your criteria Transitional Cell Carcinoma Renal

Robotic nephroureterectomy in a horseshoe kidney for upper tract urothelial carcinoma.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Urology, East Kent Hospitals University NHS Foundation Trust, Canterbury, UK.

Upper tract urothelial carcinoma represents a small proportion (5%-10%) of all urothelial cancers. Although there are several management options, in undifferentiated or high-risk cases, surgery in the form of nephroureterectomy is the gold standard. Horseshoe kidney is the most common congenital renal fusion anomaly affecting 1 in 400-600 patients. Read More

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Upper tract transitional cell carcinoma clinically mimicking inflammatory renal pathology: A report of three cases.

Indian J Urol 2021 Apr-Jun;37(2):169-172. Epub 2021 Apr 1.

Department of Urology and Renal Transplant, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Upper tract urothelial carcinoma (UTUC) of the renal pelvis and the ureter is incidentally detected in a small proportion of cases. However, the majority of UTUC cases present with hematuria, flank pain, and clot colic. Typical imaging features include hydronephrosis of the kidney (s) due to obstruction by the mass with a soft-tissue lesion that typically shows low-grade enhancement with or without a filling defect. Read More

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Checkpoint inhibition in combination with an immunoboost of external beam radiotherapy in solid tumors (CHEERS): study protocol for a phase 2, open-label, randomized controlled trial.

BMC Cancer 2021 May 7;21(1):514. Epub 2021 May 7.

Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.

Background: While the introduction of checkpoint inhibitors (CPIs) as standard of care treatment for various tumor types has led to considerable improvements in clinical outcome, the majority of patients still fail to respond. Preclinical data suggest that stereotactic body radiotherapy (SBRT) could work synergistically with CPIs by acting as an in situ cancer vaccine, thus potentially increasing response rates and prolonging disease control. Though SBRT administered concurrently with CPIs has been shown to be safe, evidence of its efficacy from large randomized trials is still lacking. Read More

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Risk of Covid-19 infection after resection of high grade transitional cell carcinoma with renal impairment.

Int J Surg Case Rep 2021 May 27;82:105924. Epub 2021 Apr 27.

Department of Special Surgery/Division of ENT, The University of Jordan, School of Medicine, Queen Rania Street, Amman 11942, Jordan.

Introduction And Importance: Covid-19 pandemic has had huge impact on health care system and put the health care system under strain, so efforts made to minimize the elective surgeries however some surgeries especially those for high risk malignant tumors cannot be postponed.The aim of this case report is to highlight the importance of screening cancer patients and those with co-morbidities such as renal impairment for Covid-19 and encouraging them to get vaccinated before undergoing elective surgeries.

Case Presentation: We report a case of an 80 year old male patient with renal impairment who developed Covid-19 infection after transurethral resection of high grade transitional cell carcinoma of urinary bladder. Read More

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Primer malignant giant cell tumour of kidney: a case report.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Sitki Kocman University, Mugla, Turkey.

Osteoclast-like giant cell tumours of the kidney are extremely rare and usually accompanied by a conventional urothelial neoplasm such as papillary, transitional renal cell, or sarcomatoid carcinoma. Although they have morphological features similar to those of the giant cell tumours in the skeletal system, their counterparts in the urinary system show highly malignant features. Our case is the third primer malignant giant cell tumour of the kidney in the literature. Read More

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J Zoo Wildl Med 2021 Apr;52(1):145-156

Wildlife Conservation Society, Zoological Health Program, Bronx Zoo, Bronx, NY 10460, USA,

The objective of this 20-yr retrospective study was to review and summarize causes of mortality in the North American (NA) snow leopard population to inform and enhance animal health and husbandry practices. Pathology reports were requested from all NA zoological institutions housing snow leopards that died between 01 January 1999 and 31 December 2019. Data were reviewed and cause of death (COD) and concurrent diseases were summarized and compared by age group, organ system, and disease process. Read More

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Retroperitoneal laparoscopic partial resection of the renal pelvis for urothelial carcinoma: A case report.

World J Clin Cases 2021 Mar;9(8):1916-1922

Department of Urology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, Liaoning Province, China.

Background: The standard treatment of transitional cell carcinoma of the upper urinary tract consists of radical nephroureterectomy with bladder cuff removal, which can be performed either in open or laparoscopy or robot-assisted laparoscopy. Treatment of chronic renal insufficiency patients with upper urothelial tumor is in a dilemma. Urologists weigh and consider the balance between tumor control and effective renal function preservation. Read More

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Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.

Oncology 2021 18;99(6):345-358. Epub 2021 Mar 18.

Urology Unit, University of Foggia, Bonomo Teaching Hospital, Foggia, Italy.

Background: The most common bladder cancer (BC) histotype is pure urothelial carcinoma (UC), which may undergo divergent differentiation in some cases. Variant histology (VH) presents along variable morphologies, either single or combined between them or with pure UC. From a clinical standpoint, the vast majority of BC is diagnosed at non-invasive or minimally invasive stages, namely as non-muscle invasive BC (NMIBC). Read More

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Fumarate hydratase-deficient renal cell carcinoma presenting as pelvicalyceal filling defect: an unusual presentation of a rare disease.

BMJ Case Rep 2021 Mar 10;14(3). Epub 2021 Mar 10.

Department of Urology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

A 75-year-old man was referred to our urology service with painless haematuria. The delayed phase on a subsequent computed tomography (CT) abdomen and pelvis showed a filling defect in the left renal pelvicalyceal system, suspicious for a transitional cell carcinoma. The patient underwent ureteroscopic biopsy suggestive of a papillary neoplasia, before progressing to a laparoscopic radical left nephrouretectomy. Read More

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Large distal ureteric stone with high burden urothelial cancer of the entire ureter and renal pelvis: a dual pathology.

Ann R Coll Surg Engl 2021 Apr 5;103(4):e136-e139. Epub 2021 Mar 5.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Upper-tract urothelial cancer comprises only 3% of all urothelial cancers. Risk factors include tobacco smoking, recurrent urinary infection, urolithiasis and analgesic abuse. Urolithiasis-induced chronic inflammation leads to urothelial proliferation and eventual malignant transformation. Read More

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Pathologically diagnosed incidentaloma transition cell carcinoma (TCC) of renal pelvis in a laproscopic radical nephrectomy specimen done for a lower pole renal mass.

Urol Case Rep 2021 Jul 11;37:101607. Epub 2021 Feb 11.

Apollo Hospitals, Indore, India.

We are reporting a very rare case in the current era of modern diagnostics of an incidentally detected Transitional Cell Carcinoma(TCC) renal pelvis, detected pathologically when Right laparoscopic radical nephrectomy specimen of lower pole mass(RCC) was processed, with no prior suspicion of TCC clinically or pre-operative imaging. A 75-year-old female with 4 × 4cm strongly enhancing lower pole renal mass on CTscan underwent a Laparoscopic Radical Nephrectomy. Surprisingly histopathological examination revealed a focus of low-grade TCC, arising from renal pelvis, completely separate from lower pole mass which was a clear cell RCC. Read More

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The first case report of synchronous primary papillary type 2 renal cell carcinoma of kidney and transitional cell carcinoma of bladder.

Urol Case Rep 2021 Jul 11;37:101601. Epub 2021 Feb 11.

Urology Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Synchronous presentation of Multiple Primary Malignant neoplasms in genitourinary system is not a common event. Absolute majority of reported cases are concurrent outbreak of clear cell type renal cell carcinoma in the kidney and transitional cell carcinoma in ipsilateral renal pelvic. We reported concurrent presenting of two separate primary malignancies, urothelial cell carcinoma of bladder and papillary renal cell carcinoma Type 2 in kidney in a 59-year-old man for the first time. Read More

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Outcome of patients with advanced upper tract urothelial carcinoma treated with immune checkpoint inhibitors: A systematic review and meta-analysis.

Crit Rev Oncol Hematol 2021 Mar 2;159:103241. Epub 2021 Feb 2.

Medical Oncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.

Background: Advanced upper tract urothelial carcinoma (UTUC) has different molecular and genetic features from the commonest carcinoma of the bladder, suggesting a possible different sensitivity to immune-checkpoint inhibitors (ICI).

Methods: A systematic review and meta-analysis of all relevant clinical studies including advanced UTUC patients treated with ICI was conducted according to PRISMA guidelines.

Results: Six prospective trials for a total 2537 patients, including 396 (15. Read More

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[Clinicopathological characteristics and prognosis of young patients with upper tract urethelial carcinoma].

Zhonghua Bing Li Xue Za Zhi 2021 Feb;50(2):90-96

Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100083, China.

To investigate the clinicopathological characteristics and prognosis of the young patients with upper tract urothelial carcinoma (UTUC). The clinical data of 839 UTUC patients receiving radical nephroureterectomy at Peking University Third Hospital, Beijing, China from September 1999 to September 2019 were retrospectively analyzed. The patients were divided into the young (<55 years old, 107 cases) and elderly groups (≥55 years old, 732 cases). Read More

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February 2021

Mixed histology bladder cancer as a complication of clam ileocystoplasty.

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Department of Urology, Northern Care Alliance NHS Group, Manchester, UK.

A 58-year-old woman with a previous clam ileocystoplasty was referred to the urology department for the investigation of haematuria. CT urogram showed a large left-sided soft tissue mass arising from the bladder. Histological analysis of the shavings from transurethral resection revealed a G3pT2 transitional cell carcinoma and T4N1Mx adenocarcinoma. Read More

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January 2021

Right Renal Pelvis Renal Cell Carcinoma Mimicking Transitional Cell Carcinoma: Case Report.

J Endourol Case Rep 2020 29;6(4):536-539. Epub 2020 Dec 29.

Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey, USA.

Renal cell carcinoma (RCC) originates from the renal parenchyma, whereas transitional cell carcinoma (TCC) originates from the renal urothelium. Although renal pelvis TCC is relatively rare in terms of urologic malignancies, it is the most common tumor originating in renal pelvis. A 75-year-old woman presented with gross hematuria found to have a filling defect in the renal pelvis with retrograde pyelogram and cytology showed clusters of urothelial cells, with imaging suspicious for TCC. Read More

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December 2020

Inflammatory Pseudotumor of the Renal Pelvis.

J Endourol Case Rep 2020 29;6(4):405-408. Epub 2020 Dec 29.

Department of Oncopathology, Tata Medical Center, Kolkata, India.

Inflammatory pseudotumor of the kidney is a rare disease of unknown etiology. There are no specific clinical or radiologic findings. The lesion can mimic renal cell carcinoma or transitional cell carcinoma depending on the site of involvement. Read More

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December 2020

Imaging Characterization of Renal Masses.

Medicina (Kaunas) 2021 Jan 8;57(1). Epub 2021 Jan 8.

Radiology Department, Hospital Clinic, University of Barcelona (UB), 08036 Barcelona, Spain.

The detection of a renal mass is a relatively frequent occurrence in the daily practice of any Radiology Department. The diagnostic approaches depend on whether the lesion is cystic or solid. Cystic lesions can be managed using the Bosniak classification, while management of solid lesions depends on whether the lesion is well-defined or infiltrative. Read More

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January 2021

Rarest of the Rare Metastatic Tubulocystic Carcinoma of Kidney.

Cureus 2020 Dec 17;12(12):e12117. Epub 2020 Dec 17.

Medical Oncology, Sultan Qaboos University Hospital, Muscat, OMN.

Tubulocystic carcinoma of the kidney is a rare neoplasm with <100 case reports. Patients are usually asymptomatic and have a relatively indolent disease course occurring predominantly in males. These tumors rarely metastasize. Read More

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December 2020

Mini invasive approaches in the treatment of small renal masses: TC-guided renal cryoablation in elderly.

Arch Ital Urol Androl 2020 Dec 17;92(4). Epub 2020 Dec 17.

University of Foggia, Department of Urology and Organ Transplantation, Foggia; Department of Urology, Bonomo Teaching Hospital, Andria (BAT).

Background: Today, the goal of surgery is to achieve oncological efficacy with the lowest complication rate. Computed Tomography (CT)-guided cryoablation is proposed as a safe and effective technique. We report, our series of small renal masses treated with cryoablation in elderly (> 70 years). Read More

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December 2020

Assessment of a clinical pathway for investigation of haematuria that reduces the need for cystoscopy.

N Z Med J 2020 12 18;133(1527):71-82. Epub 2020 Dec 18.

Clinical Writer and Analyst, Canterbury Initiative, Canterbury District Health Board, Christchurch.

Aim: To evaluate prospectively a clinical pathway for investigation of haematuria that involves an initial screening using a urinary biomarker of bladder cancer (Cxbladder Triage™ (CxbT)) in combination with either a renal ultrasound or a computed tomography imaging. Only test-positive patients are referred for specialist assessment and flexible cystoscopy.

Methods: The clinical outcomes of 884 patients with haematuria who presented to their general practitioner were reviewed. Read More

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December 2020

[Local and systhemic immunotherapy for bladder cáncer: from bench to bedside.]

Arch Esp Urol 2020 12;73(10):879-894

Servicio y Catedra de Urología. Hospital Universitario "Puerta de Hierro - Majadahonda". Universidad Autónoma de Madrid. Facultad de Medicina. Madrid. España.

Therapeutic approaches for treatment of urothelial transitional cell carcinoma based on immune system modulation, as well as the contribution of intravesica Bacillus de Calmette-Guérin (BCG) and the recentin corporation of checkpoint inhibitors had found irrefutable proofs of concept for the indication of antitumoral immunontherapy in such tumors. Its extension and development at the present time covers all the locations of the wide spectrum of presentation and evolution of these tumors. Nowadays, apart for the low grade non muscle-invasive tumors, we are facingan unpredictable development of antitumoral immunotherapy in bladder cancer not only as an option in the primary treatment, but also in other scenarios such asnon-responders when it comes to BCG, or the situation of ineligibility for systemic chemotherapy indication. Read More

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December 2020

Multiple Primary Malignancies of the Colon, Stomach, and Kidney in a Patient with Bowel Obstruction Requiring Emergency Surgery: A Case Report.

Am J Case Rep 2020 Nov 27;21:e926472. Epub 2020 Nov 27.

Department of Pathology, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

BACKGROUND Multiple primary malignancy (MPM) is defined as 2 or more primary malignancies diagnosed in the same patient. Even though MPMs are rare, various associated tumors have been reported in the literature. We report the first case of triple synchronous primary malignancies: gastrointestinal stromal tumor, colon adenocarcinoma, and renal cell carcinoma. Read More

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November 2020

Complete retroperitoneal laparoscopic nephroureterectomy with bladder cuff excision for upper tract urothelial carcinoma without patient repositioning: a single-center experience.

J Int Med Res 2020 Nov;48(11):300060520973915

Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Objective: This study was performed to evaluate the outcome of complete retroperitoneal laparoscopic nephroureterectomy with bladder cuff excision (RLNU-BCE), which is performed to treat urothelial carcinomas in the renal pelvis or in the ureter higher than the crossing of the common iliac artery without patient repositioning.

Methods: We retrospectively analyzed the clinical data of 48 patients with upper tract urothelial carcinoma who underwent complete RLNU-BCE in our institution from May 2017 to September 2019.

Results: RLNU-BCE was successfully performed in all 48 patients. Read More

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November 2020

The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database.

Int J Clin Oncol 2021 Mar 24;26(3):569-577. Epub 2020 Nov 24.

Research Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.

Purpose: The metabolic syndrome was associated with bladder cancer in the previous studies. However, there have no large-scale cohort studies to elucidate the relationship between metabolic syndromes and urothelial carcinoma including urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC).

Methods: We analyze a population-based cohort study by using physical examination data and diagnosis of UC from the Taiwan Cancer Registry Database. Read More

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Endoscopic Treatment for Large Multifocal Upper Tract Urothelial Carcinoma.

J Urol 2021 Apr 20;205(4):1039-1046. Epub 2020 Nov 20.

The Department of Urology, Sheba Medical Center, Tel Hashomer, Israel.

Purpose: We reviewed the oncologic and surgical outcomes of endoscopic treatments for low grade upper tract urothelial carcinoma, and assessed the prognostic significance of tumor size, location and multifocality.

Materials And Methods: We retrospectively reviewed all patients who underwent endoscopic treatment for low grade upper tract urothelial carcinoma at our institution between 2014 and 2019. Tumors were treated with a dual laser generator, which alternately produces holmium and neodymium lasers. Read More

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Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma.

Vet Res Forum 2020 15;11(3):289-293. Epub 2020 Sep 15.

Biopulse Ltd., Naples, Italy.

Electroporation is a technique that increases the uptake of chemotherapeutic drugs by tumors. Electrochemotherapy (ECT) has been successfully used to treat solid tumors. Recently, novel applications have been explored in the treatment of visceral tumors. Read More

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September 2020

532 nm green-light laser vaporization of upper tract urothelial carcinoma.

BMC Urol 2020 Oct 28;20(1):172. Epub 2020 Oct 28.

Department of Urology, Houston Methodist Hospital, 6560 Fannin Street, Suite 2100, Houston, TX, 77030, USA.

Background: Endoscopic management of low risk upper tract urothelial carcinoma (UTUC) may be considered in select clinical scenarios, which allows sparing the morbidity of radical nephroureterectomy while achieving acceptable oncological outcomes and preservation of kidney function. Herein, we present a case with UTUC in a solitary kidney managed with 532 nm laser vaporization through a percutaneous approach.

Case Presentation: The patient in this video (Additional file 1) is an 85-year-old woman who presented with a bulky tumor in the collecting system of a congenital solitary left kidney, which was a biopsy proven low grade urothelial carcinoma. Read More

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October 2020

Histopathologic Correlates of Kidney Function: Insights From Nephrectomy Specimens.

Am J Kidney Dis 2021 03 21;77(3):336-345. Epub 2020 Oct 21.

Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

Rationale & Objective: Existing data sets correlating kidney histopathologic findings with kidney function have low proportions of elderly patients (and those with a family history of kidney failure are over-represented), which limits their generalizability. Our objective was to use non-neoplastic tissue from nephrectomy specimens to examine the association between degree of histopathologic changes and estimated glomerular filtration rate (eGFR) and determine whether the association differed by age.

Study Design: Cross-sectional study. Read More

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