40,293 results match your criteria Transitional Cell Carcinoma Renal


Novel microbial community composition and carbon biogeochemistry emerge over time following saltwater intrusion in wetlands.

Glob Chang Biol 2018 Dec 9. Epub 2018 Dec 9.

Department of Biology, Trani Center for Life Sciences, Virginia Commonwealth University, Richmond, Virginia.

Sea level rise and changes in precipitation can cause saltwater intrusion into historically freshwater wetlands, leading to shifts in microbial metabolism that alter greenhouse gas emissions and soil carbon sequestration. Saltwater intrusion modifies soil physicochemistry and can immediately affect microbial metabolism, but further alterations to biogeochemical processing can occur over time as microbial communities adapt to the changed environmental conditions. To assess temporal changes in microbial community composition and biogeochemical activity due to saltwater intrusion, soil cores were transplanted from a tidal freshwater marsh to a downstream mesohaline marsh and periodically sampled over 1 year. Read More

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December 2018

Patterns of structural change in gonads of the divine dwarfgoby Eviota epiphanes as they sexually transition.

J Fish Biol 2018 Dec 7. Epub 2018 Dec 7.

University of Hawai'i at Mānoa 2538 McCarthy Mall Edmondson Hall 216 Honolulu, Hawai'I, USA.

This study documents changes in gonadal structure for the serial hermaphrodite (or bidirectional sex changer) divine dwarfgoby Eviota epiphanes (family Gobiidae) as individuals transition in both directions. To evaluate transitional gonad morphology, individuals actively producing the same gamete type (oocytes or sperm) were set up into pairs and euthanised over a period of 14 days to get a time series of morphological changes during gonad transformation. Results from this study show that rapid changes in the gonad take place at a structural level as individuals change their reproductive function and gamete production. Read More

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December 2018

Recommendations for Iliosacral Screw Placement in Dysmorphic Sacrum based on Modified In-Out-In Corridors.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

Clinic of Orthopaedics and Sportsorthopaedics, Klinikum rd. Isar, Technische Universität München, Munich, Germany.

(1) Can iliosacral osseous corridor diameters in sacral dysmorphism be enlarged by in-out-in screw placement at the posterior iliosacral recessus? (2) Are lumbosacral transitional vertebra (LSTV) the anatomical cause for sacral dysmorphism? (3) Are there sex-specific differences in sacral dysmorphism? 594 multislice CT scans were screened for sacral dysmorphism and 55 data-sets selected. Each pelvis was segmented manually and cylindrical iliosacral corridors (S1 and S2 vertebra) were semi-automatically determined. Corridor trajectories, -diameters and -lengths were measured. Read More

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December 2018

Local injection of RANKL facilitates tooth movement and alveolar bone remodeling.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Korea.

Objectives: To investigate the effect of local injection of receptor activator of nuclear factor kappa B ligand (RANKL) on experimental tooth movement and subsequent alveolar bone remodeling in mice.

Materials And Methods: Sixty mice were randomised to receive daily local RANKL or phosphate-buffered saline injections in the buccal premaxillary bone for 14 of 21 days of incisor movement, followed by a 21-day retention period. Five mice from each group were euthanised on days 0, 3, 7, 14, 21, and 42, and specimens were prepared for haematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemical staining. Read More

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December 2018

Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev 2018 Dec 11;12:CD011594. Epub 2018 Dec 11.

Faculty of Medicine, SEGi University, Hospital Sibu, Jalan Ulu Oya, Sibu, Sarawak, Malaysia, 96000.

Background: Several dual bronchodilator combinations of long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest the use of LABA/LAMA combinations in people with group B COPD with persistent symptoms, group C COPD with further exacerbations on LAMA therapy alone and group D COPD with or without inhaled corticosteroids (ICS). Fixed-dose combination (FDC) of aclidinium/formoterol is one of the approved LABA/LAMA therapies for people with stable COPD. Read More

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December 2018

Grob Special Issue: Homosexuality and Psychoanalysis Meet at a Mental Hospital: An Early Institutional History.

Authors:
Naoko Wake

J Hist Med Allied Sci 2018 Dec 10. Epub 2018 Dec 10.

Psychoanalysis and homosexuality in the United States were both largely in flux between 1910 and 1935. This article sheds light on this unique historical moment by first exploring scholarly discussions of the era's psychoanalysis and homosexuality, both of which emphasized the transitional nature of therapy and sexuality. By putting two bodies of scholarship into conversation, I also suggest how the historiography might move beyond two oft-cited arguments-that the psychoanalysis of the era had the power to form a person's sexual identity negatively, and that sexual minorities formed their identities affirmatively by staying away from medical interventions. Read More

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December 2018

Analysis of bone osteometry, mineralization, mechanical and histomorphometrical properties of tibiotarsus in broiler chickens demonstrates a influence of dietary chickpea seeds (Cicer arietinum L.) inclusion as a primary protein source.

PLoS One 2018 11;13(12):e0208921. Epub 2018 Dec 11.

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.

This study was focused on analyzing the effects of dietary inclusion of raw chickpea seed as a replacement of soybean meal as a primary protein source on bone structure in broiler chickens. Broiler chickens (n = 160) received in their diet either soybean meal (SBM) or raw chickpea seeds (CPS) as a primary protein source throughout the whole rearing period (n = 80 in each group). On the 42th day randomly selected chickens from each group (n = 8) were slaughtered. Read More

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December 2018

An elective entrustable professional activity-based thematic final medical school year: an appreciative inquiry study among students, graduates, and supervisors.

Adv Med Educ Pract 2018 15;9:837-845. Epub 2018 Nov 15.

Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands,

Purpose: The transition from undergraduate to postgraduate training can be facilitated by offering electives that focus on increased patient care responsibilities. This transitional year model in the Netherlands has recently been expanded to offer packages of electives geared to specific residencies and was called "dedicated transitional year" (DTY). At University Medical Center Utrecht, an entrustable professional activity (EPA)-based multidisciplinary DTY in acute care (DTY-AC), rooted in self-determination theory (SDT), has been implemented. Read More

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November 2018

Melatonin combined with chondroitin sulfate ABC promotes nerve regeneration after root-avulsion brachial plexus injury.

Neural Regen Res 2019 Feb;14(2):328-338

Department of Hand Surgery, the Second Hospital of Jilin University, Changchun, Jilin Province, China.

After nerve-root avulsion injury of the brachial plexus, oxidative damage, inflammatory reaction, and glial scar formation can affect nerve regeneration and functional recovery. Melatonin (MT) has been shown to have good anti-inflammatory, antioxidant, and neuroprotective effects. Chondroitin sulfate ABC (ChABC) has been shown to metabolize chondroitin sulfate proteoglycans and can reduce colloidal scar formation. Read More

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February 2019

Transforming phosphorus use on the island of Ireland: A model for a sustainable system.

Sci Total Environ 2018 Nov 29;656:852-861. Epub 2018 Nov 29.

School of Biological Sciences and the Institute for Global Food Security, The Queen's University of Belfast, United Kingdom.

Phosphorus is an essential part of the world food web and a non-substitutable nutrient in all biological systems. Losses of phosphorus occur along the food-supply chain and cause environmental degradation and eutrophication. A key global challenge is to meet rising worldwide food demand while protecting water and environmental quality, and seeking to manage uncertainty around potential future phosphorus price or supply shocks. Read More

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November 2018

Factors contributing to sag in unfused tetanic contractions of fast motor units in rat medial gastrocnemius.

J Electromyogr Kinesiol 2018 Nov 28;44:70-77. Epub 2018 Nov 28.

Department of Neurobiology, Poznan University of Physical Education, Poland; Division of Biochemistry, Poznan University of Physical Education, Poland.

The sag phenomenon can be observed in fast motor units (MUs) as a transitional decline in force during unfused tetanic contractions; however, its mechanisms are poorly understood. The study aimed to identify in the rat muscle factors that contribute to sag in two types of fast MUs: fast fatigable (FF) and fast resistant to fatigue (FR). First, we performed mathematical decomposition of sagging tetanic contractions of FF and FR MUs into twitch-like responses to consecutive stimuli. Read More

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November 2018
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Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis.

Best Pract Res Clin Rheumatol 2018 04 19;32(2):206-222. Epub 2018 Nov 19.

ARUK Centre for Epidemiology, Stopford Building, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, M13 9PT, UK. Electronic address:

Juvenile idiopathic arthritis (JIA) is the most common inflammatory joint condition of childhood and represents seven JIA subtypes characterised by distinct clinical and laboratory variables. Genetic and environmental factors are known to influence JIA, although many unanswered questions remain. Measurement of health outcomes in JIA is imperative for both clinical practice and research. Read More

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Comparison of gadoxetic acid versus gadopentetate dimeglumine for the detection of hepatocellular carcinoma at 1.5 T using the liver imaging reporting and data system (LI-RADS v.2017).

Cancer Imaging 2018 Dec 7;18(1):48. Epub 2018 Dec 7.

Department of Radiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Medical Imaging, No138, Fenglin Road, Xuhui District, Shanghai, 200032, China.

Purpose: The goal of this study was to investigate the Liver Imaging Reporting and Data System (LI-RADS) v.2017 for the categorization of hepatocellular carcinomas (HCCs) with gadoxetic acid compared with gadopentetate dimeglumine-enhanced 1.5-T magnetic resonance imaging (MRI). Read More

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December 2018

Pain could negatively affect school grades - Swedish middle school students with low school grades most affected.

PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.

Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More

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December 2018
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Loss of ARHGEF1 causes a human primary antibody deficiency.

J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.

ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopoietic cells. We used whole-exome sequencing to identify compound heterozygous mutations in ARHGEF1, resulting in the loss of ARHGEF1 protein expression in two primary-antibody-deficient siblings presenting with recurrent severe respiratory tract infections and bronchiectasis. Both ARHGEF1-deficient patients showed an abnormal B cell immunophenotype, with a deficiency in marginal-zone and memory B cells and an increased frequency of transitional B cells. Read More

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December 2018

The conus medullaris ratio: A new way to identify tethered cord on MRI.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Radiology.

Purpose: Approximately 25% of patients with anorectal malformation have tethered cord. The traditional way of determining conus medullaris level on magnetic resonance imaging (MRI) relies on counting vertebrae, which may be challenging due to vertebral numeric variation, segmentation anomalies, as well as transitional vertebral body anatomy. The purpose of this study was to utilize more reliable anatomic landmarks (foramen magnum, conus termination, and the upper limit of the iliac crest) to establish a consistent ratio that may differentiate patients with normal and low-lying conus. Read More

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November 2018
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[The Pathogenesis of Pulmonary Emphysema - Laennec was right!]

Pneumologie 2018 Dec 3. Epub 2018 Dec 3.

Clinical Research, Thora Tech GmbH, Anwenderzentrum für Medizintechnik, Gießen.

Pulmonary emphysema is characterised by irreversible destruction and enlargement of alveolar structure distal to terminal bronchioles. Small conducting airways < 2 mm in diameter are the major site of chronic airway inflammation and obstruction in COPD patients. 80 - 90 % of the last generation of small conducting airways, the terminal bronchioles, are destroyed in patients with very severe COPD. Read More

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December 2018
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The Midgut Muscle Network of Anopheles aquasalis (Culicidae, Anophelinae): Microanatomy and Structural Modification After Blood Meal and Plasmodium vivax (Haemosporida, Plasmodiidae) Infection.

J Med Entomol 2018 Dec 1. Epub 2018 Dec 1.

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Avenida Pedro Teixeira, Manaus, PMG, Brazil.

The mosquito midgut is divided into two regions named anterior midgut (AMG) and posterior midgut (PMG). The midgut expands intensely after the blood ingestion to accommodate a large amount of ingested food. To efficiently support the bloodmeal-induced changes, the organization of the visceral muscle fibers has significant adjustments. Read More

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December 2018

Epidemiological characteristics and determinants of dengue transmission during epidemic and non-epidemic years in Fortaleza, Brazil: 2011-2015.

PLoS Negl Trop Dis 2018 Dec 3;12(12):e0006990. Epub 2018 Dec 3.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: After being eliminated during the 1950s, dengue reemerged in Brazil in the 1980s. Since then, incidence of the disease has increased, as serotypes move within and between cities. The co-circulation of multiple serotypes contributes to cycles of epidemic and interepidemic years, and a seasonal pattern of transmission is observed annually. Read More

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December 2018

Modulatory role of vermicompost and vermiwash on growth, yield and nutritional profiling of Linum usitatissimum L. (Linseed): a field study.

Environ Sci Pollut Res Int 2018 Nov 30. Epub 2018 Nov 30.

Department of Applied Sciences, I.K.G. Punjab Technical University, Jalandhar, Punjab, India.

Vermicompost, recommended inorganic fertiliser, vermiwash and their combinations were used in the present study to know their impact on the germination, growth, yield, oil content and nutritional status in seeds of two varieties of Linum usitatissimum L. LC-54 and LC-2063. Eight treatments, in 48 plots with three replicates, were studied and compared with control. Read More

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November 2018
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Primary transitional cell carcinoma of penis - A rare presentation.

Urol Case Rep 2019 Mar 23;23:25-26. Epub 2018 Nov 23.

University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.

Primary transitional cell carcinoma arising from the anterior portion of the male urethra is rare, with no recent cases reported in the literature. We present a case of penile TCC with positive urine cytology and a delayed definitive diagnosis. Read More

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Scale and strength oak-mesophyte interactions in a transitional oak-hickory forest.

Can J For Res 2018 Nov 29;48(11):1366-1372. Epub 2018 Aug 29.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109.

Forests in eastern North America are undergoing rapid compositional changes as they experience novel climate, disturbance, and pest conditions. One striking pattern is the replacement of canopy oaks spp.) by mesic, fire-sensitive, shade-tolerant species like red maple . Read More

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November 2018

Tocilizumab in the treatment of systemic-onset juvenile idiopathic arthritis - single-centre experience.

Reumatologia 2018 31;56(5):279-284. Epub 2018 Oct 31.

Department of Paediatric Cardiology and Rheumatology, Medical University of Łódź, Poland.

Objectives: The aim of the study was to evaluate the efficacy and long-term safety of tocilizumab treatment in children with systemic-onset juvenile idiopathic arthritis in a single centre.

Material And Methods: The study was based on a retrospective analysis of a cohort of 10 patients with systemic-onset juvenile idiopathic arthritis who were treated with tocilizumab in the period September 2011-July 2017. Their medical records were analysed taking into consideration the effectiveness of tocilizumab treatment and frequency of side effects. Read More

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October 2018

[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

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December 2018
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CLINICAL ETHICS COMMITTEES: OVERVIEW OF THE EUROPEAN EXPERIENCE.

Authors:
N Pitskhelauri

Georgian Med News 2018 Oct(283):171-175

I. Javakhishvili Tbilisi State University, Georgia.

Making appropriate medical decisions in the best interest of the patient and in a line with the patient's autonomy, rights, dignity and plurality of values, are very important. In order to reach those goals and develop patient-oriented health service, Clinical Ethics Committees (CECs) support could make a great contribution. European countries (Netherland, Belgium, Italy, Germany, Norway, UK) are experiencing an exponential rise in the number of CECs as a mechanism to address the new ethical dilemmas in clinical settings, however the practice of CECs are facing barriers in transitional countries in central, eastern, and southeastern Europe. Read More

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October 2018

Peripheral blood lymphocyte subset repertoires are biased and reflect clinical features in patients with dermatomyositis.

Scand J Rheumatol 2018 Dec 5:1-5. Epub 2018 Dec 5.

a Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.

Objective: Dermatomyositis (DM) is an idiopathic inflammatory myopathy which often involves the lungs. DM is likely to be associated with aberrant T- and B-cell activation in the pathogenesis because of the proven effectiveness of T- and B-cell-targeted treatments. Assuming that the aberrant activation is reflected by biases in the lymphocyte subset repertoires, we aimed to elucidate these biases, especially in relation to clinical features of DM. Read More

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December 2018

Differentiation between inflammatory myofibroblastic tumor and cholangiocarcinoma manifesting as target appearance on gadoxetic acid-enhanced MRI.

Abdom Radiol (NY) 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul, 135-710, Republic of Korea.

Purpose: To determine the differential features of inflammatory myofibroblastic tumor (IMT) and intrahepatic cholangiocarcinoma (ICC) manifesting as target appearance on gadoxetic acid-enhanced MRI.

Methods: Twenty-seven patients with 36 IMTs (1.2-6. Read More

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December 2018
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Factors associated with attendance at primary care appointments after discharge from hospital: a retrospective cohort study.

CMAJ Open 2018 Oct-Dec;6(4):E587-E593. Epub 2018 Dec 3.

Department of Medicine (Lam, Abrams, Okrainec), University of Toronto; Division of General Internal Medicine (Abrams, Okrainec), University Health Network; Biostatistics Research Unit (Matelski), University Health Network, Toronto, Ont.

Background: Follow-up with a primary care provider within 1-2 weeks of discharge from hospital has been associated with reduced readmissions. We sought to determine appointment attendance with primary care providers postdischarge and identify factors associated with attendance.

Methods: We conducted a retrospective cohort study involving general medicine patients who had been discharged from hospital between Sept. Read More

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December 2018

Effects of salinity changes on aquatic organisms in a multiple stressor context.

Philos Trans R Soc Lond B Biol Sci 2018 Dec 3;374(1764). Epub 2018 Dec 3.

Instituto de Ciencias Ambientales (ICAM), Universidad de Castilla-La Mancha, Toledo, Spain.

Under global change, the ion concentration of aquatic ecosystems is changing worldwide. Many freshwater ecosystems are being salinized by anthropogenic salt inputs, whereas many naturally saline ones are being diluted by agricultural drainages. This occurs concomitantly with changes in other stressors, which can result in additive, antagonistic or synergistic effects on organisms. Read More

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December 2018
2 Reads

Recurrent oligometastatic transitional cell bladder carcinoma: is there room for radiotherapy?

Neoplasma 2018 Sep 4. Epub 2018 Sep 4.

Division of Radiation Oncology, European Institute of Oncology, Milan, Italy.

The aim of our study was to retrospectively report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed. The primary endpoint was to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer the start of a systemic therapy. Read More

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September 2018
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The prognostic significance of androgen receptor and β-catenin immunohistochemical expression in urothelial carcinoma with and without detrusor muscle invasion from an Egyptian institution.

Pol J Pathol 2018 ;69(3):234-242

Androgen receptor (AR) activation plays an important role in the promotion and progression of urothelial tumorigenesis. Also, dysregulation of the Wnt/β-catenin signaling pathway has also been linked to bladder cancer growth. However, cross talk between the two pathways in remains unclear in bladder cancer. Read More

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January 2018

Clinicopathological characteristics of breast sebaceous adenocarcinoma.

Pol J Pathol 2018 ;69(3):226-233

Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More

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January 2018
2 Reads

Biogeographical zonation of rocky intertidal communities along the coast of Peru (3.5-13.5° S Southeast Pacific).

PLoS One 2018 30;13(11):e0208244. Epub 2018 Nov 30.

Laboratorio de Ciencias del Mar, Universidad Peruana Cayetano Heredia, Lima, Perú.

The biogeography of the Peruvian Eastern Pacific coast has been described based on oceanographic parameters and qualitative species occurrence data. This has generated disagreement about the limits and existence of different biogeographic units. In this study, the distribution of rocky-shore macrobenthic communities were recorded over 41 sites along the Peruvian coastline (3. Read More

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November 2018
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Co-adsorption of a Monoclonal Antibody and Nonionic Surfactant at the SiO2/water Interface.

ACS Appl Mater Interfaces 2018 Nov 30. Epub 2018 Nov 30.

During the formulation of therapeutic monoclonal antibodies (mAbs), nonionic surfactants are commonly added to attenuate structural rearrangement caused by adsorption/desorption at interfaces during processing, shipping and storage. We examined the adsorption of a mAb (COE-3) at the SiO2/water interface in the presence of pentaethylene glycol monododecyl ether (C12E5), polysorbate 80 (PS80-20EO) and a polysorbate 80 analogue with 7 ethoxylates (PS80-7EO). Spectroscopic ellipsometry (SE) was used to follow COE-3 dynamic adsorption and neutron reflection (NR) was used to determine interfacial structure and composition. Read More

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November 2018
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Solitary fibrous tumor/hemangiopericytoma of the optic canal.

Clin Neuropathol 2018 Nov 30. Epub 2018 Nov 30.

Solitary fibrous tumor/hemangiopericytoma seldom arises from the optic nerve sheath. Herein, we describe the clinical, radiological, and histological findings of a solitary fibrous tumor/hemangiopericytoma arising from the optic nerve sheath and occupying the optic canal. The diagnosis is challenging both clinically and histologically as it clinically simulates a commoner lesion, i. Read More

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November 2018

Outcome Prediction of Prostatic Artery Embolization (PAE): Post hoc analysis of a randomized, open label, non-inferiority trial.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology and Nuclear Medicine, St Gallen Cantonal Hospital, St Gallen, Switzerland.

Objectives: To identify predictive parameters of different treatment outcomes after prostatic artery embolization (PAE) in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Patients And Methods: A post-hoc analysis of data derived from the 48 patients undergoing PAE in a randomized, open label, non-inferiority trial was performed. Relative changes in the International Prostate Symptoms Score (IPSS), absolute changes in maximum flow rate, and relative changes in MRI-assessed prostate volume from baseline to 12 weeks were defined as the outcomes measures of interest. Read More

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November 2018

Report of a Chinese Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome.

J Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical Immunology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Purpose: We aimed to report the clinical manifestations and immunological features of activated phosphatidylinositol 3-kinase δ syndrome 1 (APDS1) in a Chinese cohort. Moreover, we investigated the efficacy and safety of rapamycin therapy for Chinese patients with APDS1.

Methods: Fifteen Chinese patients with APDS1 from 14 unrelated families were enrolled in this study. Read More

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November 2018
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Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor.

Nat Commun 2018 11 29;9(1):5055. Epub 2018 Nov 29.

Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, 97239, OR, USA.

Membrane proteins are universal signal decoders. The helical transmembrane segments of these proteins play central roles in sensory transduction, yet the mechanistic contributions of secondary structure remain unresolved. To investigate the role of main-chain hydrogen bonding on transmembrane function, we encoded amide-to-ester substitutions at sites throughout the S4 voltage-sensing segment of Shaker potassium channels, a region that undergoes rapid, voltage-driven movement during channel gating. Read More

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November 2018
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Biomechanical assessment of proximal junctional semi-rigid fixation in long-segment thoracolumbar constructs.

Authors:

J Neurosurg Spine 2018 Oct 1:1-9. Epub 2018 Oct 1.

OBJECTIVEProximal junctional kyphosis (PJK) and failure (PJF) are potentially catastrophic complications that result from abrupt changes in stress across rigid instrumented and mobile non-fused segments of the spine (transition zone) after adult spinal deformity surgery. Recently, data have indicated that extension (widening) of the transitional zone via use of proximal junctional (PJ) semi-rigid fixation can mitigate this complication. To assess the biomechanical effectiveness of 3 semi-rigid fixation constructs (compared to pedicle screw fixation alone), the authors performed cadaveric studies that measured the extent of PJ motion and intradiscal pressure changes (ΔIDP). Read More

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October 2018

Immunohistochemical analysis of histone H3 acetylation in the trigeminal root entry zone in an animal model of trigeminal neuralgia.

Authors:

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEThe trigeminal root entry zone (TREZ) is a transitional zone between the central nervous system (CNS) and peripheral nervous system (PNS), adjacent to the brainstem. Microvascular compression of the TREZ has been considered to be the primary etiology in most cases of trigeminal neuralgia (TN), but whether epigenetic regulation is involved in the pathogenesis of TN is still unclear. Therefore, this study was designed to investigate the epigenetic regulation of histone H3 acetylation in the TREZ in an animal model of TN. Read More

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November 2018

Critical roles of IκBα and RelA phosphorylation in transitional oscillation in NF-κB signaling module.

J Theor Biol 2018 Nov 27;462:479-489. Epub 2018 Nov 27.

Center for Mathematical Modeling and Data Science, Osaka University, Osaka, Japan.

The transcription factor NF-κB performs various cell functions, such as regulating proliferation and differentiation and blocking apoptosis, by inducing the expression of multiple genes. The shuttling of NF-κB between the cytoplasm and nucleus is involved in its transcriptional activity in the canonical NF-κB pathway. The transcription of the NF-κB target genes is regulated by the phosphorylation of both IκBα and the RelA subunit of NF-κB, suggesting that these phosphorylation events are crucial for the oscillation. Read More

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November 2018
4 Reads

Mechanical Properties and Microstructural Collagen Alignment of the Ulnar Collateral Ligament During Dynamic Loading.

Am J Sports Med 2018 Nov 29:363546518812416. Epub 2018 Nov 29.

Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA.

Background:: The ulnar collateral ligament (UCL) microstructural organization and collagen fiber realignment in response to load are unknown.

Purpose/hypothesis:: The purpose was to describe the real-time microstructural collagen changes in the anterior bundle (AB) and posterior bundle (PB) of the UCL with tensile load. It was hypothesized that the UCL AB is stronger and stiffer with more highly aligned collagen during loading when compared with the UCL PB. Read More

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November 2018
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Structural Dynamics of the Fibrous Basis of Reparative Regenerate during Spontaneous Healing of the Skin Wound.

Bull Exp Biol Med 2018 Dec 28;166(2):274-278. Epub 2018 Nov 28.

N. N. Priorov Central Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Moscow, Russia.

Structural dynamics of the fibrous basis of the reparative regenerate during spontaneous skin wound healing comprises multiple stages, it successively transforms from one organization level to another more complex level, forms a multilevel 3D structure including molecular, supramolecular, fibrillar, fiber, and tissue elements. The formed reparative regenerate is integrated with the preserved skin, together they have common fibrous basis consisting of three parts that are different in organization of fibrous structures: atypical (central), tissue organospecific (peripheral), and transitional. Read More

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December 2018
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Objective Uniaxial Identification of Transition Points in Non-Linear Materials: Sample Application to Porcine Coronary Arteries and the Dependency of Their Pre- and Post-Transitional Moduli with Position.

Cardiovasc Eng Technol 2018 Nov 28. Epub 2018 Nov 28.

Department of Mechanical Engineering, University of Birmingham, Birmingham, B15 2TT, UK.

Purpose: This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries.

Methods: Eight coronary arteries were divided into proximal, middle and distal test specimens. Specimens underwent uniaxial extension up to 3 mm. Read More

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November 2018
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Sterols in human milk during lactation: bioaccessibility and estimated intakes.

Food Funct 2018 Nov 29. Epub 2018 Nov 29.

Nutrition and Food Science Area, Faculty of Pharmacy, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 - Burjassot (Valencia), Spain.

Human milk (HM) is the exclusive food during the first 4-6 months of an infant's life. Breastfeeding has been related to significant health benefits for infants, and hence it is of interest to study the bioactive compounds present in HM, such as sterols (cholesterol being the most abundant). The aim of this study was to determine the contents of sterols (cholesterol, desmosterol, lathosterol, lanosterol, campesterol, stigmasterol and β-sitosterol) in 10 pools of colostrum, transitional milk, and 1, 3 and 6 month HM obtained from Spanish volunteers from two different geographical areas (coastal and central) and to estimate the intake and bioaccessibility (BA) of sterols in order to ascertain the fate of sterols after digestion. Read More

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November 2018
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Facilitating Effective Transitions from Hospital to Community for Children and Adolescent Mental Health Services: Overview of the Transition Support Worker Role and Function.

J Can Acad Child Adolesc Psychiatry 2018 Nov 1;27(4):228-235. Epub 2018 Nov 1.

East Metro Youth Services, Toronto, Ontario.

Transitions between hospital and community services and from child and adolescent to adult services have been identified as a priority for improvement in the child and adolescent mental health and addictions sector across Canada and internationally. Despite widespread recognition of the issue, there is very little in the way of evidence to guide policy and programming to improve transitions. Transition support workers have been identified as a promising intervention to facilitate successful transitions, and innovative programs involving transition workers are currently operating in the Canadian mental health sector. Read More

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November 2018

Lower Urinary Tract Neoplasia.

Vet Sci 2018 Nov 27;5(4). Epub 2018 Nov 27.

School of Veterinary Medicine, University of California-Davis, 1 Garrod Drive, Davis, CA 95616, USA.

Lower urinary tract neoplasia in companion animals is a debilitating and often life-threatening disease. Tumors of the bladder, urethra, and prostate often occur independently, although extension of these tumors into adjacent regions of the lower urinary tract is documented frequently. The most common lower urinary tract tumor in dogs and cats is transitional cell carcinoma (TCC). Read More

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November 2018

The Association Between Chronic Condition Symptoms and Treatment Burden in a Skilled Nursing Population.

J Gerontol Nurs 2018 Dec;44(12):45-52

The purpose of the current study was to determine the relationship between chronic condition symptoms and treatment burden in older adults transitioning from skilled nursing facilities to home. Treatment burden is defined as the burden associated with adhering to a prescribed chronic condition self-management regimen. Analysis of correlations between chronic condition symptoms and treatment burden revealed that symptoms and treatment burden are positively correlated (p < 0. Read More

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December 2018

Contextualising sexual health practices among lesbian and bisexual women in Jamaica: a multi-methods study.

Reprod Health Matters 2018 Dec;26(52):1517543

k Lecturer, Institute for Gender and Development Studies, Mona Campus, University of the West Indies , Kingston , Jamaica.

Limited research has examined lesbian and bisexual women's sexual health practices in the Caribbean, where lesbian and bisexual women experience sexual stigma that may reduce sexual healthcare utilisation. We conducted a sequential multi-method research study, including semi-structured individual interviews (n = 20) and a focus group (n = 5) followed by a cross-sectional survey (n = 205) with lesbian and bisexual women in Kingston, Montego Bay, and Ocho Rios, Jamaica. Binary logistic analyses and ordinal logistic regression were conducted to estimate the odds ratios for social-ecological factors associated with lifetime STI testing, sex work involvement, and the last time of STI testing. Read More

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December 2018
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Classification in para sport for athletes following cervical spine trauma.

Authors:
Greg Ungerer

Handb Clin Neurol 2018 ;158:371-377

Transitional Rehabilitation Program, Queensland, Spinal Cord Injuries Service, Brisbane, Australia. Electronic address:

Classification of athletes for para sport is a complex process, and provides the necessary structure for competition. Classification systems aim to ensure that para athletes achieve sporting excellence. By minimizing the effect of the impairment on sports performance, classification systems ensure para sport is not dominated by those athletes with the least impairment, but rather athletic excellence is the key determinant of success. Read More

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January 2018
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