2,983 results match your criteria Transitional Cell Carcinoma Renal


Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.

World J Urol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., J8.130, Dallas, TX, 75390-9110, USA.

Purpose: To evaluate the prognostic value of BRCA1-associated protein-1 (BAP1) expression in upper tract urothelial carcinoma (UTUC), as BAP1 mutations have been associated with prognostic implications in urologic and non-urologic malignancies.

Methods: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy (RNU) for high-grade UTUC from 1990-2008. Immunohistochemistry (IHC) for BAP1 was performed on tissue microarrays. Read More

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http://link.springer.com/10.1007/s00345-019-02678-x
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http://dx.doi.org/10.1007/s00345-019-02678-xDOI Listing
February 2019
5 Reads

Differentiating intrapulmonary metastases from different primary tumors via quantitative dual-energy CT based iodine concentration and conventional CT attenuation.

Eur J Radiol 2019 Feb 14;111:6-13. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.

Materials And Methods: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183045
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http://dx.doi.org/10.1016/j.ejrad.2018.12.015DOI Listing
February 2019
6 Reads

Imaging of Unusual Renal Tumors.

Curr Urol Rep 2019 Jan 21;20(1). Epub 2019 Jan 21.

Department of Radiology, University of Miami/Miller School of Medicine, 1611 NW 12th Avenue, Miami, FL, 33136, USA.

Purpose Of Review: Renal masses are a wide entity and a common finding in clinical practice. Detection of these masses has increased in the last years, yet mortality rates have slightly decreased.

Recent Findings: According to the World Health Organization classification, there are 8 types, 51 subtypes, and a lot more subsequent subclassifications of renal tumors. Read More

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http://link.springer.com/10.1007/s11934-019-0867-7
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http://dx.doi.org/10.1007/s11934-019-0867-7DOI Listing
January 2019
7 Reads

Urologic Oncology.

Vet Clin North Am Small Anim Pract 2019 Mar 8;49(2):311-323. Epub 2019 Jan 8.

Piper Memorial Veterinary Center, 730 Randolph Road, Middletown, CT 06457, USA.

Primary renal tumors are an uncommon diagnosis in small animals. Presentation, treatment, and prognosis depend on tumor type. Surgery with or without chemotherapy are the mainstays of treatment. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.11.006DOI Listing
March 2019
3 Reads

High Serum CA19-9 Concentration Indicates High Chemosensitivity and Better Survival in Advanced Urothelial Carcinoma.

Anticancer Res 2019 Jan;39(1):375-380

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Background: The present study was conducted to investigate whether baseline serum carbohydrate antigen (CA) 19-9 predicts prognosis or treatment effect in patients with advanced urothelial carcinoma (UC).

Materials And Methods: We retrospectively analyzed data of patients diagnosed with locally advanced or metastatic or recurrent UC between April 2008 and November 2014. CA19-9 was determined using enzyme-linked immunosorbent assay (ELISA) and the relationship between CA19-9 and prognosis were analyzed. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13122DOI Listing
January 2019
9 Reads

Superselective vesical artery embolization in the management of intractable hematuria secondary to hemorrhagic cystitis.

World J Urol 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, University of Texas Medical Branch, Galveston, TX, 77555-0709, USA.

Purpose: To evaluate the efficacy and outcome of superselective vesical arterial embolization in the management of severe intractable hematuria secondary to hemorrhagic cystitis.

Materials And Methods: We retrospectively reviewed the medical records of nine patients with severe intractable hematuria treated with superselective vesical artery embolization at our institution between March 2003 and February 2015. There were six males and three females with a mean age of 56. Read More

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http://dx.doi.org/10.1007/s00345-018-2604-0DOI Listing
December 2018
3 Reads
2.666 Impact Factor

Predictive ability of renal cortex enhancement in dynamic computed tomography for residual renal function after nephroureterectomy: Comparison with Tc-diethylenetriaminopentacetic acid renography and validation study.

Int J Urol 2019 02 27;26(2):266-272. Epub 2018 Oct 27.

Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

Objective: To estimate postoperative residual renal function after radical nephroureterectomy for upper tract urothelial carcinoma using the preoperative dynamic computed tomography renal cortex enhancement ratio in comparison with the split kidney glomerular filtration rate measured by Tc-diethylenetriaminopentacetic acid renography.

Methods: A total of 47 patients who received radical nephroureterectomy and underwent both preoperative dynamic computed tomography and renography were the model-development cohort; and 109 patients who underwent dynamic computed tomography alone were the validation cohort. Postoperative renal function of the unremoved kidney was estimated using the following formulas: preoperative estimated glomerular filtration rate × the percentage of total renal cortex radiodensity for the intact kidney in Hounsfield units obtained from corticomedullary phase images in the computed tomography-based model, or the percentage of the total glomerular filtration rate measured by renography in the nuclear model. Read More

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http://doi.wiley.com/10.1111/iju.13855
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http://dx.doi.org/10.1111/iju.13855DOI Listing
February 2019
11 Reads

[French ccAFU guidelines - Update 2018-2020: Upper tract urothelial carcinoma].

Prog Urol 2018 Nov 11;28(12S):S32-S45. Epub 2018 Oct 11.

Comité de cancérologie de l'Association française d'urologie, groupe vessie, Maison de l'Urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie, hôpital Européen-Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France.

Introduction: To propose an update of the French guidelines from the national committee ccAFU on upper tract urothelial carcinomas (UTUC).

Methods: A systematic Medline search was performed between 2016 and 2018, with regards to the diagnosis, the options of treatment and the follow-up of UTUC, to evaluate the different studies with levels of evidence.

Results: The diagnosis of this rare disease is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087183046
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http://dx.doi.org/10.1016/j.purol.2018.07.284DOI Listing
November 2018
12 Reads

Evaluation of upper tract urothelial carcinomas by contrast-enhanced ultrasound.

Radiologia 2018 Nov - Dec;60(6):496-503. Epub 2018 Sep 25.

Servicio de Radiodiagnóstico, Hospital Universitario Doctor Peset, Valencia, España.

Aim: To describe the findings and behaviour of contrast-enhanced ultrasound in the study of upper tract urothelial tumours and to assess its usefulness for diagnosis.

Material And Methods: We reviewed our hospital's database over a period of 45 months to identify patients diagnosed with upper tract urothelial carcinomas. We reviewed the findings on mode B-ultrasound, contrast-enhanced ultrasound (location and qualitative assessment of intensity and washout of enhancement), and made a comparison with other techniques (computed tomography or magnetic resonance), and with the surgical specimen. Read More

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http://dx.doi.org/10.1016/j.rx.2018.07.005DOI Listing
September 2018
10 Reads

[Impact of first-line chemotherapy on renal function in patients with advanced upper tract urothelial carcinoma].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(32):2574-2578

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing 100142, China.

To observe the impact of first-line chemotherapy on renal function in patients with unresectable/metastatic upper tract urothelial carcinoma(UTUC). A total of 222 (130 males and 92 females) unresectable/metastatic upper tract urothelial carcinoma patients were included in the study between January 2005 and May 2017, with age of 29 to 87 (62.4±10. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.32.008DOI Listing
August 2018
3 Reads

Clinical and histopathological features of carcinosarcoma of the renal pelvis: a systematic review of a rare tumour.

Minerva Urol Nefrol 2018 Sep 10. Epub 2018 Sep 10.

Department of Urology, Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.

Introduction: Carcinosarcoma of the kidney pelvis (CRP) is a rare but not exceptionally unique tumor in which in literature are reported almost only case studies and small series. We aim to provide a comphrensive overview of the disease, examining epidemiology, symptoms, pathological features, treatment and outcomes which are still missing, in order to offer a landmark paper to urologists which have to manage patients with this type of disease.

Evidence Acquisition: A review of the current literature was conducted through the NCBI PubMed database in June 2017 following the updated PRISMA guidelines. Read More

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http://dx.doi.org/10.23736/S0393-2249.18.03192-2DOI Listing
September 2018
2 Reads

The significance of the initial symptom in Chinese patients with upper tract urothelial carcinoma: Regular health examination is still underutilized.

Kaohsiung J Med Sci 2018 Sep 3;34(9):511-521. Epub 2018 Mar 3.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, China.

This paper is to elucidate the correlation between different symptoms of UTUC and the clinicopathological characteristics and prognosis. The clinicopathological data of 700 consecutive patients with UTUC who were treated with radical nephroureterectomy were reviewed, and symptoms were categorized into three groups: S1-no direct symptoms, S2-local symptoms (including hematuria and flank pain) and S3-systemic symptoms. We found that the distributions of patients in the S1, S2 and S3 groups were 96 (13. Read More

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http://dx.doi.org/10.1016/j.kjms.2018.01.003DOI Listing
September 2018
4 Reads
0.800 Impact Factor

Immunohistochemical Pitfalls in Genitourinary Pathology: 2018 Update.

Adv Anat Pathol 2018 Nov;25(6):387-399

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Immunohistochemistry may be a very useful adjunct to morphologic diagnosis in many areas of surgical pathology, including genitourinary pathology. In this review, we address common diagnostic dilemmas where immunophenotypic analysis may be utilized and we highlight pitfalls specific to each scenario. For prostate, we review the diagnosis of limited prostatic adenocarcinoma and the distinction of high-grade prostatic adenocarcinoma from urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000205DOI Listing
November 2018
6 Reads

Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

BMC Urol 2018 Jul 31;18(1):68. Epub 2018 Jul 31.

Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Background: Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical resection.

Methods: We analyzed surgical tumor samples from 74 UC patients who had received radical cystectomy (n = 40) or ureteronephrectomy (n = 34). Read More

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http://dx.doi.org/10.1186/s12894-018-0380-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069868PMC
July 2018
1 Read

A Complex Cardiac Mass Originating from Interatrial Septum in a Patient with History of Kidney Cancer: A Case Report and Literature Review.

Case Rep Cardiol 2018 31;2018:1764057. Epub 2018 May 31.

Department of Medicine, Presence Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.

Cardiac tumors are a rare phenomenon, and most cases are secondary to metastatic cancers rather than primary tumors. Renal cell carcinoma (RCC) is notorious for metastasis to cardiac tissue. Tumor thrombus migration to the renal vein and inferior vena cava happens in up to 10% of patients with RCC. Read More

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http://dx.doi.org/10.1155/2018/1764057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000876PMC
May 2018
2 Reads

The two-faced nature of BK polyomavirus: lytic infection or non-lytic large-T-positive carcinoma.

J Pathol 2018 Sep 31;246(1):7-11. Epub 2018 Jul 31.

Department of Genetics, The University of North Carolina, Chapel Hill, NC, USA.

In immunocompromised patients, reactivation of latent BK polyomavirus (BKPyV) can cause disease with lytic infections of the kidneys and the lower urinary tract. Emerging evidence also links BKPyV to oncogenesis and high-grade intrarenal and transitional cell carcinomas. These neoplasms strongly express polyomavirus large-T antigen as a defining feature; that is, they are 'large-T-positive carcinomas'. Read More

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http://dx.doi.org/10.1002/path.5127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120561PMC
September 2018
10 Reads

[Usefulness of cold ureteral biopsy during radical cystectomy as a predictor of recurrence risk: Review of our series.]

Arch Esp Urol 2018 Jun;71(5):486-494

Servicio de Urología. Hospital Universitario Central de Asturias. Oviedo. Asturias. España.

Objectives: To evaluate the association of positive margins in the intraoperative biopsy during radical cystectomy (RC) with the risk of recurrence in the uretero-ileal anastomosis or upper urinary tract (UUT), and identify potential risk factors for positive ureteral margins.

Methods: A retrospective, descriptive study was performed in patients treated with radical cystectomy due to transitional cell carcinoma (TCC), who underwent a cold biopsy of the ureteral margin at the time of cystectomy. A descriptive analysis and frequency distribution was performed. Read More

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June 2018
28 Reads

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma.

Biomed Res Int 2018 26;2018:2793172. Epub 2018 Apr 26.

Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

This study aimed to compare the oncological and renal outcomes of partial ureterectomy (PU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). UTUC patients' clinical information was reviewed, and progression-free survival (PFS), overall survival (OS), and kidney function were collected. The mean follow-up period was 59 (6-135) months in the RNU group and 34. Read More

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http://dx.doi.org/10.1155/2018/2793172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944270PMC
October 2018
2 Reads

Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report.

BMC Nephrol 2018 05 30;19(1):123. Epub 2018 May 30.

Ultrasound Learning Center EFSUMB, Klinik Hirslanden, Zürich, Switzerland.

Background: Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and dysmorphic vessels, is defined as a potentially benign. The usual or classic angiomyolipoma is often found incidentally on imaging studies, relatively easily identified due to the presence of fat, in contrast to the epithelioid angiomyolipoma that can pose diagnostic challenges.

Case Presentation: We report a 51-year-old female patient in which an ultrasonography examination showed a solid mass close to the right renal pelvis with hypoechoic and hyperechoic areas. Read More

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http://dx.doi.org/10.1186/s12882-018-0919-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975514PMC
May 2018
9 Reads

Endoscopic Management of Upper Urinary Tract Urothelial Carcinoma.

J Endourol 2018 May;32(S1):S10-S16

The Smith Institute for Urology, Department of Urology, Zucker School of Medicine at Hofstra/Northwell , New Hyde Park, New York.

Introduction: Endoscopic management of upper tract urothelial carcinoma has become more popular over the last few decades as there has been an impetus for renal preservation in these patients. While radical nephroureterectomy has been the gold standard in treatment of this disease, ureteroscopic and percutaneous management has become a viable option for select patients.

Methods And Materials: The literature on endoscopic management of upper urinary tract tumors was explored. Read More

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http://dx.doi.org/10.1089/end.2018.0036DOI Listing
May 2018
3 Reads

Urothelial carcinoma of an allograft ureter 10 years after deceased donor kidney transplantation.

BMJ Case Rep 2018 May 12;2018. Epub 2018 May 12.

Department of Urology, Beaumont Hospital, Dublin, Ireland.

The incidence of urothelial carcinoma (UC; formerly transitional cell carcinoma) is higher among renal transplant recipients compared with the general population. Upper urinary tract UC (UUT-UC) of allograft urothelium is a rare event with approximately 40 cases reported in the literature. Herein, we describe the clinical presentation and management of UUT-UC in a transplant ureter 10 years after deceased donor kidney transplantation. Read More

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http://dx.doi.org/10.1136/bcr-2017-223087DOI Listing
May 2018
4 Reads

De Novo Urologic Malignancies in Renal Transplant Recipients.

Transplant Proc 2018 Jun 10;50(5):1348-1354. Epub 2018 Mar 10.

Department of Urology and Renal Transplantation, Coimbra University Hospital Center, Coimbra, Portugal.

Background: Immunosuppressed organ transplant patients have an elevated risk of malignancies. The aim of this study was to determine the incidence of urologic malignancies in renal transplant recipients, as well as to evaluate their monitoring, treatment, and outcomes.

Methods: We conducted a retrospective single-center study of 2897 renal transplants between January 1987 and December 2016. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.086DOI Listing
June 2018
4 Reads

Oncologic Outcomes of Post-Kidney Transplantation Superficial Urothelial Carcinoma.

Transplant Proc 2018 May;50(4):998-1000

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Purpose: To analyze the oncologic effect of post-kidney transplantation (KT) immunosuppressive status for end-stage renal disease (ESRD) patients with superficial urothelial carcinoma.

Methods: From 2010 to 2015, there were 106 ESRD patients with superficial urinary bladder urothelial carcinoma (UB-UC) and 68 ESRD patients with superficial upper urinary tract urothelial carcinoma (UT-UC) in a single institution. Oncologic outcomes including bladder cancer recurrences and systemic disease recurrences within 5 years were compared between patients with and without KT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183009
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http://dx.doi.org/10.1016/j.transproceed.2018.01.031DOI Listing
May 2018
3 Reads

Renal Pelvis Carcinoma with Renal Vein or Inferior Vena Cava Involvement Linked to Early-onset Lung Metastasis Based on CT Scan Diagnosis.

Anticancer Res 2018 05;38(5):3187-3192

Department of Medical Imaging and Intervention, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.

Background/aim: Renal pelvis cancer with invasion of the renal vein or inferior vena cava (IVC) carries a poor prognosis. The present study investigated whether early-onset lung metastasis in these patients contributes to their poor outcome.

Patients And Methods: Data were retrospectively collected from hospitalized patients with metastatic renal pelvis urothelial cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12583DOI Listing
May 2018
4 Reads

A Genitourinary Cancer-specific Scoring System for the Prediction of Survival in Patients with Bone Metastasis: A Retrospective Analysis of Prostate Cancer, Renal Cell Carcinoma, and Urothelial Carcinoma.

Anticancer Res 2018 05;38(5):3097-3103

Department of Urology, Nara Medical University, Kashihara, Japan.

Aim: The aim of this study was to develop a risk scoring system specific to patients with bone metastasis of genitourinary cancer.

Materials And Methods: This study included 180 patients with bone metastasis of three major types of genitourinary cancer: prostate cancer (n=111), renal cell carcinoma (n=43,), and urothelial carcinoma (n=26). Clinical factors at diagnosis of bone metastasis were evaluated to identify independent prognostic factors. Read More

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http://dx.doi.org/10.21873/anticanres.12568DOI Listing
May 2018
4 Reads

Coincidental Bladder Cuff Transitional Cell Carcinoma in Nephroureterectomy Specimens: Risk Factors, Prognosis and Clinical Implementation.

Urol J 2018 Sep 26;15(5):256-260. Epub 2018 Sep 26.

Mafraq Hospital, United Arab Emirates.

Purpose: There is a lack of reporting of the bladder cuff pathology in the literature and ongoing debate regarding the role of bladder cuff excision (BCE) in the prognosis in patients with upper tract urothelial carcinoma (UTUC). We aimed to know the risk factors, the survival, and the clinical course of such pathology.

Materials And Methods: The study was retrospective, from 1983-2013 on 305 patients who had diagnosed with UTUC. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4069DOI Listing
September 2018
10 Reads

[Treatment with PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors : Immune-mediated side effects].

Urologe A 2018 May;57(5):543-551

Urologische Klinik und Poliklinik Jena, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Immune checkpoint inhibitors are a new standard therapy for advanced or metastatic urothelial as well as renal cell carcinoma. Atezolizumab and Pembrolizumab have been approved for the treatment of cisplatin-ineligible patients with transitional call cancer in the 1st line setting; both antibodies and Nivolumab may also be used after platinum based prior therapy. Regarding renal cell carcinoma approval for 1st line treatment with the combination of Nivolumab and Ipilimumab for patients at intermediate or high risk (IMDC) is currently expected. Read More

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http://dx.doi.org/10.1007/s00120-018-0635-1DOI Listing
May 2018
8 Reads

Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients.

Eur Urol 2018 07 10;74(1):10-14. Epub 2018 Apr 10.

Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospital, London, UK.

There remains a lack of consensus among guideline relating to which patients require investigation for haematuria. We determined the incidence of urinary tract cancer in a prospective observational study of 3556 patients referred for investigation of haematuria across 40 hospitals between March 2016 and June 2017 (DETECT 1; ClinicalTrials.gov: NCT02676180) and the appropriateness of age at presentation in cases with visible (VH) and nonvisible (NVH) haematuria. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.03.008DOI Listing
July 2018
5 Reads
13.940 Impact Factor

Perioperative Immunotherapy in Muscle-Invasive Bladder Cancer and Upper Tract Urothelial Carcinoma.

Urol Clin North Am 2018 May;45(2):287-295

Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

Neoadjuvant chemotherapy improves survival in patients with muscle-invasive bladder cancer. However, a significant proportion of patients are ineligible for cisplatin owing to renal impairment or other medical comorbidities. The introduction of anti-programmed cell death protein 1/programmed death-ligand 1(PD1/PD-L1) checkpoint inhibitors has redefined the therapeutic landscape for platinum-resistant urothelial cancers; their clinical efficacy and favorable toxicity render these agents attractive therapeutic options either as monotherapy or in combination with other agents in earlier disease states, including muscle-invasive disease. Read More

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http://dx.doi.org/10.1016/j.ucl.2017.12.011DOI Listing
May 2018
3 Reads

Follow-up Management of Cystectomy Patients.

Urol Clin North Am 2018 May;45(2):241-247

Moores Cancer Center, UC San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA. Electronic address:

Bladder cancer is the sixth leading cancer in the United States. Radical cystectomy is a lifesaving procedure for bladder cancer with or without muscle invasion. Radical cystectomy is performed on 39% of these patients, and 35% will have a life-threatening recurrence. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.01.001DOI Listing
May 2018
3 Reads

Editorial Comment from Dr Defidio to Thulium laser ablation facilitates retrograde intra-renal surgery for upper urinary tract urothelial carcinoma.

Authors:
Lorenzo Defidio

Int J Urol 2018 04 25;25(4):381-382. Epub 2018 Mar 25.

Department of Urology, Cristo Re Hospital, Rome, Italy.

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http://dx.doi.org/10.1111/iju.13568DOI Listing
April 2018
1 Read

Prognostic Factors and Risk Stratification in Invasive Upper Tract Urothelial Carcinoma.

Clin Genitourin Cancer 2018 08 6;16(4):e751-e760. Epub 2018 Feb 6.

Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Background: Upper tract urothelial carcinoma (UTUC) accounts for approximately 5% of all urothelial cancers. Because of similarities in morphology and histology between UTUC and urothelial carcinoma of the bladder, most treatment guidelines used for UTUC are extrapolated from the urothelial bladder carcinoma setting. With the emergence of new treatment modalities, such as immunotherapy, UTUC-specific prognostic and predictive models are needed. Read More

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http://dx.doi.org/10.1016/j.clgc.2018.01.014DOI Listing
August 2018
13 Reads

Ki-67 as a Prognostic Marker in Upper Urinary Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis.

Clin Genitourin Cancer 2018 08 24;16(4):e831-e841. Epub 2018 Feb 24.

Department of Urology, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: We systematically evaluated the prognostic significance of Ki-67 on survival outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).

Materials And Methods: We searched the Embase, Scopus, and PubMed databases for all articles published up to February 2017 by following the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. The outcomes of interest included intravesical recurrence (IVR)-free survival, disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS). Read More

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http://dx.doi.org/10.1016/j.clgc.2018.02.010DOI Listing
August 2018
5 Reads

Quantitative evaluation of canine urinary bladder transitional cell carcinoma using contrast-enhanced ultrasonography.

BMC Vet Res 2018 Mar 12;14(1):84. Epub 2018 Mar 12.

Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, 98168, Messina, Italy.

Background: In veterinary medicine, contrast-enhanced ultrasonography allowed the accurate quantification of liver, splenic and kidney vascularization in healthy dogs and the differentiation between malignant and benign hepatic, renal, and splenic nodules in dogs and cats based on perfusion patterns. The utility of contrast-enhanced ultrasonography in other applications is still under study. The aim of this study was to develop diagnostic criteria by contrast-enhanced ultrasonography in 8 client-owned adult dogs affected by urinary bladder transitional cell carcinoma with definitive diagnosis made by cytopathologic evaluation after suction biopsy. Read More

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http://dx.doi.org/10.1186/s12917-018-1384-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848439PMC
March 2018
7 Reads

Editorial Comment from Dr Castelli to Thulium laser ablation facilitates retrograde intra-renal surgery for upper urinary tract urothelial carcinoma.

Int J Urol 2018 04 8;25(4):380-381. Epub 2018 Mar 8.

Division of Urology, San Giovanni Bosco Hospital, Turin, Italy.

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http://dx.doi.org/10.1111/iju.13545DOI Listing
April 2018
1 Read

[Clinicopathologic features with collecting duct carcinoma of kidney: report of 10 cases].

Zhonghua Bing Li Xue Za Zhi 2018 Feb;47(2):123-127

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To study the pathological features, immunophenotypes, differential diagnoses and prognostic parameters of collecting duct carcinoma of the kidney (CDC). Clinical imaging, histopathology, immunohistochemistry, and survival data of 10 patients at First Affiliated Hospital of Nanjing Medical University from January 2009 to August 2017 were retrospectively analyzed along with a review of literatures. The clinical symptoms of CDC were not specific, and image examinations showed space-occupying mass lesions. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.02.009DOI Listing
February 2018
5 Reads

Upper Urinary Tract Urothelial Cancer in Croatian and Bosnian Endemic Nephropathy Regions.

Med Arch 2017 Dec;71(6):430-433

Department of Surgery, University Clinical Center Tuzla, University of Tuzla, Faculty of Medicine, Tuzla, Bosnia and Herzegovina.

Objectives: Endemic nephropathy (EN) is a chronic tubulointerstitial renal disease associated with increased incidence of upper urinary tract urothelial cancer (UTUC) occurring predominantly in geographically limited areas in villages along big Danube river. Based on results obtained by the research it is confirmed that aristolochic acid is causative agent of endemic nephropathy (EN).

Aim: The aim of this study was to determine characteristics of UTUC in two endemic areas and analyze trends in 5-year period. Read More

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http://www.ejmanager.com/fulltextpdf.php?mno=284909
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http://dx.doi.org/10.5455/medarh.2017.71.430-433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788511PMC
December 2017
4 Reads

Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist.

Med Clin North Am 2018 Mar;102(2):231-249

Center for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Q10-1, Cleveland, OH 44195, USA. Electronic address:

Malignancies of the urinary tract (kidney, ureter, and bladder) are distinct clinical entities. Hematuria is a unifying common presenting symptom for these malignancies. Surgical management of localized disease continues to be the mainstay of treatment, and early detection is important in the prognosis of disease. Read More

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http://dx.doi.org/10.1016/j.mcna.2017.10.002DOI Listing
March 2018
4 Reads

Asymptomatic solitary bladder plasmocytoma: A case report and literature review.

Medicine (Baltimore) 2017 Dec;96(50):e9347

Department of Urology and Renal Transplantation.

Rationale: Solitary extramedullary plasmocytoma may arise in any organ, either as a primary tumor or as part of a systemic myeloma; if it rarely affects bladder, it presents with urinary symptoms. We describe the first case of asymptomatic BP occasionally diagnosed in a patient with ascites.

Patient Concerns: A 74-year-old woman with hepatitis C virus (HCV)-related liver cirrhosis presented with ascites and no urinary or other symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000009347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815820PMC
December 2017
7 Reads

Das bewegt die Urologie – Aktuelles von den Kongressen 2017.

Aktuelle Urol 2018 Feb 1;49(1):25-36. Epub 2018 Feb 1.

Department of Urology und Pediatric Urology, Philipps University Marburg.

In 2017, many new and promising therapeutic innovations entered uro-oncology. Immunotherapy was highly topical and was intensively discussed at the annual meetings. This review summarises the news, together with future developments in the diagnosis and treatment of prostate, bladder and kidney cancer. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-123706
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http://dx.doi.org/10.1055/s-0043-123706DOI Listing
February 2018
11 Reads

Present status and future perspective of peptide-based vaccine therapy for urological cancer.

Cancer Sci 2018 Mar 15;109(3):550-559. Epub 2018 Feb 15.

Department of Urology, Iwate Medical University School of Medicine, Morioka, Japan.

Use of peptide-based vaccines as therapeutics aims to elicit immune responses through antigenic epitopes derived from tumor antigens. Peptide-based vaccines are easily synthesized and lack significant side-effects when given in vivo. Peptide-based vaccine therapy against several cancers including urological cancers has made progress for several decades, but there is no worldwide approved peptide vaccine. Read More

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http://dx.doi.org/10.1111/cas.13506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834812PMC
March 2018
5 Reads

De Novo Bladder Urothelial Neoplasm in Renal Transplant Recipients: A Retrospective, Multicentered Study.

Urol Int 2018 17;100(2):185-192. Epub 2018 Jan 17.

Department of Urology, University of Turin, Città della Salute e della Scienza, Turin, Italy.

Background And Objectives: Renal transplant recipients (RTRs) have a 2- to 7-fold risk of developing a neoplasm compared to general population. Bladder urothelial neoplasms in this cohort has an incidence of 0.4-2%. Read More

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http://dx.doi.org/10.1159/000481917DOI Listing
September 2018
24 Reads

Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period.

Prague Med Rep 2017;118(4):119-127

Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Renal cell carcinomas (RCCs) account 80-85% of all primary renal neoplasms and originate from the renal cortex. The patients who underwent radical or partial nephrectomy for renal tumour in our unit between January 2005 and 2015 were evaluated retrospectively. The patients were divided into two groups; group 1 includes patients who were treated between January 2005 and December 2009, group 2 those from January 2010 to 2015. Read More

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http://dx.doi.org/10.14712/23362936.2017.13DOI Listing
April 2018
7 Reads

Iodine Content Analysis Using Dual-Energy Computed Tomography as a Biomarker of Transitional Cell Carcinoma, an Experience with Separation of the Clotted Blood and Tumorous Tissue.

Anticancer Res 2018 01;38(1):541-545

Department of Imaging Methods, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Background/aim: The aim of this study was to evaluate the possibility to discriminate the blood clot from tumorous tissue in the assessment of transitional cell carcinoma (TCC), when CT data are used only from single-phase dual-energy CT (DECT).

Materials And Methods: A total of 18 patients were included into the retrospective analysis of the prospectively collected data (the average age was 67.3 years, range=62-79 years, 12 males, 6 females). Read More

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http://dx.doi.org/10.21873/anticanres.12256DOI Listing
January 2018
13 Reads

Cytological diagnosis of a rare case of cutaneous metastasis from transitional cell carcinoma, renal pelvis.

J Egypt Natl Canc Inst 2017 Dec 7;29(4):197-200. Epub 2017 Dec 7.

Department of Radiotherapy, VMMC & Safdarjung Hospital, New Delhi 110029, India.

Transitional cell carcinoma (TCC) arising from renal pelvis rarely gives rise to cutaneous metastasis. Due to the insufficient literature, the exact incidence is not known till date. Moreover, the diagnosis is confirmed on histopathological examination with the aid of immunohistochemistry wherever needed. Read More

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http://dx.doi.org/10.1016/j.jnci.2017.11.001DOI Listing
December 2017
15 Reads

Renal function recovery after radical nephroureterectomy for upper tract urothelial carcinoma.

World J Urol 2018 Feb 5;36(2):257-263. Epub 2017 Dec 5.

Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.

Purpose: To understand the longitudinal renal function trends in patients undergoing radical nephroureterectomy (RNU) and identify clinicopathologic characteristics associated with estimated glomerular filtration rate (eGFR) recovery.

Methods: 147 patients were available for analysis. Longitudinal eGFR trends were assessed by plotting each patient's eGFR measurements over time. Read More

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http://dx.doi.org/10.1007/s00345-017-2139-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002847PMC
February 2018
9 Reads

Preoperative chronic kidney disease is predictive of oncological outcome of radical cystectomy for bladder cancer.

World J Urol 2018 Feb 28;36(2):249-256. Epub 2017 Nov 28.

Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes after radical cystectomy (RC) for bladder cancer.

Methods: We reviewed the medical records of patients with urothelial bladder carcinoma who underwent RC with curative intent at seven hospitals between 1990 and 2013. After excluding patients with a history of upper urinary tract urothelial cancer or neoadjuvant chemotherapy, we analyzed 594 cases for the study. Read More

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http://dx.doi.org/10.1007/s00345-017-2141-2DOI Listing
February 2018
15 Reads