3,101 results match your criteria Transitional Cell Carcinoma Renal


Rare presentation of inflammatory myofibroblastic tumor in the kidney.

Radiol Case Rep 2020 Aug 17;15(8):1266-1270. Epub 2020 Jun 17.

Department of Radiology, King Hamad University Hospital, Manama, Bahrain.

Inflammatory myofibroblastic tumor (IMT) is a rare pathologic entity that has been mostly described in the lung. It has been reported in nearly every organ, with occurrence in the kidney being extremely rare. IMT has nonspecific clinical and radiological findings and often mimics a malignant process. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305367PMC

The influence of dysbiosis on kidney stones that risk up renal cell carcinoma (RCC).

Semin Cancer Biol 2020 Jun 20. Epub 2020 Jun 20.

Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla, 171 005 India. Electronic address:

Kidney stone is a common urological condition, the prevalence and incidence of which has escalated in the last few years due to dietary habits and other related medical conditions such as obesity and diabetes mellitus. It is a chronic disease which leads to loss of kidney function(s) and nephrectomy. Chronic kidney stone disease has been shown to be associated with transitional cell carcinoma (TCC) or renal cell carcinoma (RCC) and kidney tumors have been found to be more frequent among patients with kidney stones. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.06.011DOI Listing

Renal sinus angiomyolipoma: A rare case.

Urol Ann 2020 Apr-Jun;12(2):193-195. Epub 2020 Apr 14.

Department of Urology, SMS Hospital, Jaipur, Rajasthan, India.

Angiomyolipoma (AML) consists of <10% of all renal tumors and is the most common benign mesenchymal neoplasm of the kidney. It arises from the renal cortex and extends toward perirenal fat. Fat-poor AML as well as those arising from rare locations may pose diagnostic difficulties. Read More

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http://dx.doi.org/10.4103/UA.UA_134_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292437PMC

Characteristics of bladder recurrence after radical nephroureterectomy in upper urinary tract cancer

Orv Hetil 2020 05;161(21):881-888

Általános Orvostudományi Kar, Urológiai Klinika,Semmelweis Egyetem Budapest, Üllői út 26., 1085.

Introduction: Urothelial cancer can develop in the renal pelvis, ureters, bladder and the proximal urethra as urothelial tissue can be found in these organs. Upper tract urothelial carcinoma is rare but better understanding of the natural history of the disease is important because bladder recurrence often occurs after radical nephroureterectomy.

Aim And Method: Our retrospective study aims to describe the general characteristics of patients treated with radical nephroureterectomy at the Department of Urology, Semmelweis University, between January 1st, 2005 and December 31st, 2016. Read More

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http://dx.doi.org/10.1556/650.2020.31709DOI Listing

Suburothelial Hematomas Masquerading as Neoplasms in a Patient with Supra-Therapeutic INR.

Urology 2020 Jul 19;141:e22-e23. Epub 2020 Apr 19.

Department of Urology, University of Virginia, Charlottesville, VA.

Suburothelial hemorrhages (Antopol-Goldman lesions) are a rare but important condition. When unsuspected in a patient with a bleeding diathesis on anticoagulation therapy, computed tomography may lead to incorrect diagnoses of renal or transitional cell carcinoma resulting in inappropriate nephrectomy. We present a patient with supratherapeutic international normalized ratio and thigh hematoma who was found to have nonenhancing solid lesions of the bilateral renal pelves consistent with suburothelial hemorrhage. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.018DOI Listing

[Algorithms for systemic therapy of prostate cancer, transitional cell carcinoma and renal cell carcinoma].

Urologe A 2020 May;59(5):533-543

Urologikum Lübeck, Lübeck, Deutschland.

Systemic therapy in uro-oncology is currently undergoing major changes. In the past, drug therapies only showed good treatment results in metastasized testicular tumors. New developments indicate that an improved understanding of tumor biology will lead to targeted treatment strategies for metastatic prostate, urothelial and renal cell carcinoma. Read More

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http://dx.doi.org/10.1007/s00120-020-01182-0DOI Listing

Differentiation of Urothelial Carcinoma into Two Distinct Subtypes, Glandular and Squamous, in Three Different Organs.

Cureus 2020 Mar 15;12(3):e7280. Epub 2020 Mar 15.

Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, LBN.

Urothelial carcinoma (UC) is a unique entity with different histological variants: squamous, glandular, small cell, micropapillary, sarcomatoid, and plasmacytoid. Each of those subtypes behaves differently. As such, and in many scenarios, an accurate histological diagnosis is of paramount importance to dictate the therapeutic approach. Read More

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http://dx.doi.org/10.7759/cureus.7280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158603PMC

Nephron-Sparing Robotic Radiosurgical Therapy for Primary Renal Cell Carcinoma: Single-Institution Experience and Review of the Literature.

Adv Radiat Oncol 2020 Mar-Apr;5(2):204-211. Epub 2019 Oct 15.

Radiation Oncology, Colorado Springs, Colorado.

Purpose: We report our single-institution stereotactic body radiation therapy (SBRT) experience on stage I renal cancer with prospectively collected toxicity and efficacy data.

Methods And Materials: A total of 21 patients with solitary renal tumors, including 14 surgical candidates who refused surgery (66%), were treated with SBRT. Histologic confirmation was obtained on all patients before treatment; 2 had transitional cell carcinoma and 19 had renal cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.adro.2019.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136638PMC
October 2019

De Novo Malignancy After Heart, Kidney, and Liver Transplant: A Nationwide Study in Taiwan.

Exp Clin Transplant 2020 Apr 4;18(2):224-233. Epub 2020 Mar 4.

From the School of Medicine, China Medical University, Taichung, Taiwan.

Objectives: In the Asian population, patterns and risk factors for de novo malignancies after solid-organ transplant are not well understood.

Materials And Methods: Insurance claims from Taiwan's National Health Institute Research Database from 1997 to 2011 revealed 687 deceased-donor heart transplant recipients, 5038 kidney transplant recipients (50% living related-donor, 50% deceased-donor transplants), and 2127 liver transplant recipients (mainly living related-donor transplants, 30% deceased-donor transplants). During the follow-up period, rates of malignancy incidence were calculated with standardization based on national age, sex, and year-specific incidence. Read More

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http://dx.doi.org/10.6002/ect.2019.0210DOI Listing

Choice of Surgical Options in Kidney Cancer and Surgical Complications.

Semin Nephrol 2020 01;40(1):42-48

Department of Urology, The Warren Alpert Medical School of Brown University, Providence, RI; Minimally Invasive Urology Institute, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI.

Surgical resection of renal cell carcinoma plays a large role in the overall management of the disease. The gold standard for surgical management historically has been open or laparoscopic radical nephrectomy, however, evidence of equivalent oncologic efficacy with improved clinical outcomes has driven the use of nephron-sparing surgeries, especially for smaller and localized renal tumors. A role for surgery remains in metastatic RCC as well, but controversy exists as to which patients may benefit most from surgical intervention in addition to other systemic targeted therapies. Read More

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http://dx.doi.org/10.1016/j.semnephrol.2019.12.005DOI Listing
January 2020

Bellini Duct Carcinoma Misdiagnosed with Urothelial Papillary Carcinoma.

Case Rep Oncol Med 2020 10;2020:3174674. Epub 2020 Feb 10.

Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.

Background: Collecting (Bellini) duct carcinoma (CDC) or Bellini duct carcinoma (BDC) is a rare subtype of kidney tumors, accounting for less than 3% and known to have the worst prognosis. It is known to have multiple clinical presentations; this is why it can be easily misdiagnosed. The aim of this article is to present a case of CDC that was initially misdiagnosed with urothelial papillary carcinoma (UPC) in a 41-year-old male. Read More

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http://dx.doi.org/10.1155/2020/3174674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035507PMC
February 2020

Robot-Assisted Radical Cystectomy With Orthotopic Neobladder as a Urinary Diversion for a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2020 Mar 19;52(2):608-613. Epub 2020 Feb 19.

Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

Background: A higher prevalence of bladder cancer is reported in solid organ recipients, and advanced cancer requires radical cystectomy combined with urinary diversion. Surgery is technically challenging in kidney transplant recipients because of urinary tract abnormalities. Here, we describe the use of a robot-assisted approach in a kidney transplant recipient. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.12.002DOI Listing

Thulium-laser Retrograde Intra Renal Ablation (T-RIRA) of upper urinary tract transitional cell carcinoma: an ESUT study.

Minerva Urol Nefrol 2020 Jan 30. Epub 2020 Jan 30.

ESUT, European Section for UroTechnology EAU, Arnhem, the Netherland.

Background: Radical nephroureterectomy (RNU) is the gold standard treatment for upper urinary tract urothelial carcinoma (UTUC); however, patients presenting with small low-grade UTUC have been treated by flexible ureteroscopic laser ablation with good outcomes. Different types of laser have been discussed in the literature including Holmium and Neodymium lasers. We aimed to assess the safety and efficacy of Thulium laser (Tm:YAG) in the ureteroscopic ablation of UTUC. Read More

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http://dx.doi.org/10.23736/S0393-2249.20.03689-9DOI Listing
January 2020

Sarcomatoid change associated with epithelial-mesenchymal transition in mucinous tubular and spindle cell carcinoma of the kidney: a case report.

Int J Clin Exp Pathol 2019 1;12(7):2767-2771. Epub 2019 Jul 1.

Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University 19-1, Morioka 020-8505, Japan.

We report an unusual case of mucinous tubular and spindle cell carcinoma (MTSCC) with sarcomatoid change in an 80-year-old Japanese male. In a resected specimen, a grayish-white tumor was found in the left kidney, and several metastases were observed in the right cervical bone and liver. Histologically, most of the main tumor examined showed MTSCC with sarcomatoid change. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949544PMC

Imaging protocols for renal multiparametric MRI and MR urography: results of a consensus conference from the French Society of Genitourinary Imaging.

Eur Radiol 2020 Apr 3;30(4):2103-2114. Epub 2020 Jan 3.

Academic Department of Radiology, Hôpital Pitié-Salpêtrière and Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objectives: To develop technical guidelines for magnetic resonance imaging aimed at characterising renal masses (multiparametric magnetic resonance imaging, mpMRI) and at imaging the bladder and upper urinary tract (magnetic resonance urography, MRU).

Methods: The French Society of Genitourinary Imaging organised a Delphi consensus conference with a two-round Delphi survey followed by a face-to-face meeting. Two separate questionnaires were issued for renal mpMRI and for MRU. Read More

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http://dx.doi.org/10.1007/s00330-019-06530-zDOI Listing

[Evaluating the impact of preoperative anemia on the prognosis of upper tract urothelial carcinoma following radical nephroureterectomy: A single-center retrospective study of 686 patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1056-1061

Department of Urology, Peking University First Hospital, Beijing 100034, China.

Objective: To identify the effect of preoperative anemia on the prognosis of patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy.

Methods: Clinicopathological and prognosis data on 686 patients with UTUC who underwent RNU at Peking University First Hospital between January 2000 and December 2013 were retrospectively analyzed. Preoperative anemia was defined as hemoglobin <130 g/L in men and <120 g/L in women based on the World Health Organization classification. Read More

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December 2019

Primary renal cell carcinoma in crossed fused ectopia: Nephron sparing surgery for a rare of rarity entity.

Urol Case Rep 2020 Jan 17;28:101020. Epub 2019 Sep 17.

Department of Surgery, Division of Urology, King Abdullah Medical City, Makkah, KSA, Saudi Arabia.

Primary renal cell carcinoma (RCC) in crossed fused renal ectopia represents a rare of rarity entity. Only eight cases were reported in the literature, including seven RCC and one transitional cell carcinoma. This report presents a case of a 39-years old female presented with incidentally discovered renal mass in a crossed fused ectopia. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881641PMC
January 2020

Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma.

BMC Urol 2019 Nov 21;19(1):120. Epub 2019 Nov 21.

Department of Urology, First Hospital of Jilin University, Changchun, 130021, People's Republic of China.

Background: The appropriate application of various treatment for upper tract urothelial carcinomas (UTUCs) is the key to prolong the survival of UTUC patients. Herein, we used data in our database to assess the oncological outcomes between partial ureterectomy (PU) and radical nephroureterectomy (RNU).

Methods: From 2007 to 2014, 255 patients with UTUC undergoing PU or RNU in our hospital database were investigated. Read More

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http://dx.doi.org/10.1186/s12894-019-0557-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873718PMC
November 2019

Examining the upper urinary tract in patients with hematuria-time to revise the CT urography protocol?

Eur Radiol 2020 Mar 20;30(3):1664-1670. Epub 2019 Nov 20.

Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.

Background: Three-phase CT urography (CTU) is the gold standard for evaluating the upper urinary tract in patients with hematuria. We aimed to evaluate the accuracy of CTU for detecting upper urothelial cell carcinomas (UCC) in patients with hematuria and negative cystoscopy. Secondly, we aimed to determine the tumor visibility on each CTU phase. Read More

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http://dx.doi.org/10.1007/s00330-019-06521-0DOI Listing

[Influence of immunomodulators on urological imaging].

Urologe A 2019 Dec;58(12):1451-1460

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Tübingen, Deutschland.

Background: Immune checkpoint inhibitors (ICI) have led to great advances in the therapy of metastatic renal cell and urothelial carcinoma. Currently ICI are approved for the first-line therapy of cisplatin-unfit patients (Atezolizumab, Pembrolizumab) and second-line therapy in patients with metastasized urothelial cancer (Atezolizumab, Nivolumab, Pembrolizumab). For the therapy of metastasized RCC, Nivolumab is approved as a second-line therapy and in combination with the CTLA‑4 antibody Ipilimumab as a first-line therapy. Read More

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http://dx.doi.org/10.1007/s00120-019-01063-1DOI Listing
December 2019

Phase II Trial of Neoadjuvant Systemic Chemotherapy Followed by Extirpative Surgery in Patients with High Grade Upper Tract Urothelial Carcinoma.

J Urol 2020 04 8;203(4):690-698. Epub 2019 Nov 8.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: Data supporting neoadjuvant chemotherapy of high grade upper tract urothelial carcinoma are scant. In this multi-institution, prospective, phase II trial we investigated pathological complete responses after neoadjuvant chemotherapy of high grade upper tract urothelial carcinoma.

Materials And Methods: Patients with high grade upper tract urothelial carcinoma in whom nephroureterectomy was planned were assigned to 4 neoadjuvant chemotherapy cycles of accelerated methotrexate, vinblastine, doxorubicin and cisplatin in those with baseline creatinine clearance greater than 50 ml per minute or gemcitabine and carboplatin in those with creatinine clearance 30 to 50 ml per minute or less. Read More

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http://dx.doi.org/10.1097/JU.0000000000000644DOI Listing

[Cutaneous metastases from genitourinary malignancies.]

Arch Esp Urol 2019 Nov;72(9):972-974

Servicio de Urología. Hospital Universitario Cruces. Barakaldo. Bizkaia. España.

Objective: To show and report two new cases of urological cutaneous metastasis.

Methods: We describe two skin metastases cases. The first patient corresponds to a renal tumor and the other to a urothelial tumor. Read More

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November 2019

Prediction of recurrence in non-muscle invasive bladder cancer patients. Do patient characteristics matter?

J BUON 2019 Jul-Aug;24(4):1659-1665

Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey.

Purpose: To evaluate patients, diagnosed with non-muscle invasive bladder cancer, according to patient specific parameters including hemoglobin level, estimated glomerular filtration rate (eGFR), body mass index (BMI) and cigarette smoking and to identify if any of these parameters matters in terms of recurrence prediction.

Methods: 231 patients who have undergone transurethral resection of the bladder (TURB) between January 2015 and January 2018 and diagnosed with non-muscle invasive bladder cancer (NMIBC) were included. Patient demographic characteristics including age, sex, BMI and cigarette smoking were assessed. Read More

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Clinicopathologic Characterization of Post-Renal Transplantation BK Polyomavirus-Associated Urothelial CarcinomaSingle Institutional Experience.

Am J Clin Pathol 2020 02;153(3):303-314

Department of Pathology and Laboratory Medicine, Madison.

Objectives: To review rare cases of BK polyomavirus (BKPyV) associated urologic carcinomas in kidney transplant recipients at one institution and in the literature.

Methods: We describe the clinicopathologic features of BKPyV-associated urologic carcinomas in a single-institution cohort.

Results: Among 4,772 kidney recipients during 1994 to 2014, 26 (0. Read More

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http://dx.doi.org/10.1093/ajcp/aqz167DOI Listing
February 2020
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Spontaneous renoalimentary fistula as a complication of upper tract urothelial carcinoma: unknown complication of a rare disease.

BMJ Case Rep 2019 Oct 15;12(10). Epub 2019 Oct 15.

Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Fistulae of the upper urinary tract with the alimentary tract are rare. Most cases of renoalimentary fistulae are secondary to penetrating trauma, which may be iatrogenic or due to locally invasive benign infective processes or complicated nephrolithiasis, or following surgical procedures. Spontaneous renoalimentary fistulae developing secondary to locally advanced malignancies, namely renal cell carcinoma, are very rare, and unknown due to upper tract transitional cell carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2019-231720DOI Listing
October 2019
1 Read

Kidney Graft Urothelial Carcinoma: Results From a Multicentric Retrospective National Study.

Urology 2020 Jan 24;135:101-105. Epub 2019 Sep 24.

CHU de Caen, Urology and Transplantation, Caen, France. Electronic address:

Objective: To calculate the incidence of renal graft urothelial carcinoma in renal transplant recipients in a national large retrospective cohort and to analyze circumstances of diagnosis, treatment and outcome.

Material And Methods: We conducted a national retrospective, multicenter study. Thirty two transplant centers were asked to report its cases of kidney graft tumors and the number of kidney transplantations performed since the beginning of their transplantation activity. Read More

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http://dx.doi.org/10.1016/j.urology.2019.09.015DOI Listing
January 2020
2 Reads

Multicenter prospective study validating the efficacy of a quantitative assessment tool for frailty in patients with urological cancers.

Med Oncol 2019 Sep 13;36(10):88. Epub 2019 Sep 13.

Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.

We prospectively validate the efficacy of the frailty discriminant score (FDS) in individuals with urological cancers, as there has been growing importance in evaluating frailty in clinical practice. A prospective, multicenter study was conducted from February 2017 to April 2019. We enrolled 258 patients with urological cancers and 301 community-dwelling participants who were assessed for frailty. Read More

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http://dx.doi.org/10.1007/s12032-019-1313-xDOI Listing
September 2019
1 Read
2.058 Impact Factor

[Urothelial Carcinoma within a Calyceal Diverticulum Difficult to Distinguish from Cystic Renal Cell Carcinoma].

Hinyokika Kiyo 2019 Jul;65(7):291-294

The Department of Pathology, Osaka Police Hospital.

A 64-year-old man visited our hospital because of right renal cyst and microscopic hematuria which was found in a medical checkup. Contrast computed tomography (CT) and contrast magnetic resonance imaging (MRI) suggested cystic renal cell carcinoma. A laparoscopic nephrectomy was performed, and the surgical specimens showed urothelial carcinoma within the calyceal diverticulum. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_7_291DOI Listing
July 2019
1 Read

[Homolateral ureter primary small cell carcinoma and urinary tract epithelial carcinoma of the contralateral ureter and bladder after renal transplantation: report of a case].

Zhonghua Bing Li Xue Za Zhi 2019 09;48(9):735-736

Department of Pathology, the First Hospital of Jilin University, Changchun 130021, China.

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.09.018DOI Listing
September 2019
1 Read

Lymph node dissection during nephroureterectomy: Establishing the existing evidence based on a review of the literature.

Arab J Urol 2019 24;17(3):167-180. Epub 2019 Apr 24.

Department of Urology, Queen Elizabeth University Hospital, Glasgow, UK.

: To determine the role of lymph node dissection (LND) in the treatment of upper tract transitional cell carcinoma (UTTCC), as the role of LND along with nephroureterectomy in treating UTTCC is unclear and several retrospective studies have been published on this topic with conflicting results. : The Medical Literature Analysis and Retrieval System Online (MEDLINE), the Excerpta Medica dataBASE (EMBASE), Cochrane Central Register of Controlled Trials database (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Clinicaltrials.gov, Google Scholar, and individual urological journals, were searched for all studies investigating the role of LND in the treatment of UTTCC. Read More

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http://dx.doi.org/10.1080/2090598X.2019.1596401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711077PMC
April 2019
2 Reads

[Upper urinary tract tumor and hydronephrosis to pelviureteric junction obstruction: a rare association].

Pan Afr Med J 2018 22;31:201. Epub 2018 Nov 22.

Service d'Urologie, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.

The association between tumor of the urinary tract and hydronephrosis caused by a syndrome of the pyelo-ureteral junction is rare. Indeed, tumors of the upper urinary tract and hydronephrosis have generally a cause-effect relationship. This last is due, more often, to an obstruction caused by a tumor of the ureter or of the pyelo-ureteral junction. Read More

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http://www.panafrican-med-journal.com/content/article/31/201
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http://dx.doi.org/10.11604/pamj.2018.31.201.16181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691320PMC
September 2019
5 Reads

Preventive Role of mTOR Inhibitor in Post-Kidney Transplant Urothelial Carcinoma.

Transplant Proc 2019 Oct 22;51(8):2731-2734. Epub 2019 Aug 22.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: There is little evidence about whether mammalian target of rapamycin (mTOR) inhibitor could prevent post-kidney transplant (KT) urothelial carcinoma (UC) or not. The aim of this study is to analyze the role of mTOR inhibitor add-on in tacrolimus-based kidney transplant recipients.

Method: The data were obtained from the Kaohsiung Chang Gung Memorial Hospital using the Chang Gung Research Database and retrospectively reviewed from January 2000 to December 2015. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.03.059DOI Listing
October 2019
2 Reads

Carcinomas of the Renal Pelvis, Ureters, and Urinary Bladder Share a Carcinogenic Field as Revealed in Epidemiological Analysis of Tumor Registry Data.

Clin Genitourin Cancer 2019 12 19;17(6):436-442. Epub 2019 Jul 19.

Department of Preventive Medicine and Biostatistics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD.

Background: Urothelial carcinomas are the most common malignant tumors in the upper and lower urinary tract. Renal cell carcinomas (RCCs) have a different pathoepidemiologic incidence and characteristics. We describe a population-based approach of differentiating between urothelial and renal carcinomas as a basis to support shared morphologic phenotypes. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.07.011DOI Listing
December 2019

Use of Toceranib Phosphate in the Treatment of Canine Bladder Tumors: 37 Cases.

J Am Anim Hosp Assoc 2019 Sep/Oct;55(5):243-248

From Animal Cancer Care Center, Fort Lauderdale, Florida (T.L.G.); and Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado (B.B.).

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http://dx.doi.org/10.5326/JAAHA-MS-6905DOI Listing

Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study.

Photodiagnosis Photodyn Ther 2019 Dec 5;28:238-247. Epub 2019 Aug 5.

School of Engineering, Future Industries Institute, University of South Australia, South Australia, Australia. Electronic address:

Exogenous administration of the photodynamic agent hexaminolevulinate induces Protoporphyrin IX (PpIX) accumulation in malignant tissue. This may enable differentiation from healthy tissues by emission of a distinctive red fluorescence. It provides the photo-specific detection when excited with blue light at 405 nm. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.08.001DOI Listing
December 2019
2 Reads

Spinal Versus Intracranial Meningioma: Aberrant Expression of CD10 and Inhibin with Relation to Clinicopathological Features and Prognosis.

Pathol Oncol Res 2020 Apr 1;26(2):1313-1318. Epub 2019 Aug 1.

Faculty of Medicine, Tribhuvan University, Kirtipur, Nepal.

CD10 and inhibin are used mainly in CNS pathology to distinguish hemangioblastoma from metastatic clear cell renal cell carcinoma. Some meningiomas can mimic both tumors and so we aimed at this study to investigate the expression of both markers in a large number of meningioma cases. One hundred thirty-four meningioma samples were collected, 14 of them were spinal and 120 were intracranial. Read More

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http://dx.doi.org/10.1007/s12253-019-00704-2DOI Listing
April 2020
4 Reads

Organ-sparing procedures in GU cancer: part 3-organ-sparing procedures in urothelial cancer of upper tract, bladder and urethra.

Int Urol Nephrol 2019 Nov 27;51(11):1903-1911. Epub 2019 Jul 27.

Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Purpose: The impact of radical surgery for urothelial carcinoma is significant on patient's quality of life. Organ-sparing surgery (OSS) can provide comparable oncological outcomes and with improved quality of life. In this review, we summarize the indications, techniques and outcomes of OSS for these tumors. Read More

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http://dx.doi.org/10.1007/s11255-019-02232-zDOI Listing
November 2019
9 Reads

Invasive high-grade urothelial carcinoma of the bladder, renal pelvis, ureter, and prostatic urethra arising in a background of urothelial carcinoma with an inverted growth pattern: a contemporary clinicopathological analysis of 91 cases.

Hum Pathol 2019 10 24;92:18-24. Epub 2019 Jul 24.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033; Winship Cancer Institute of Emory University, Atlanta, GA 30322. Electronic address:

Urothelial carcinoma with an inverted/endophytic growth pattern can occasionally mimic inverted urothelial papilloma and pose diagnostic challenges when assessing the presence or absence of invasion. Making these distinctions is critical for guiding appropriate treatment and improving patient outcomes. Here we conducted one of the largest studies to date of invasive high-grade urothelial carcinoma arising in a background of urothelial carcinoma with an inverted growth pattern. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.07.005DOI Listing
October 2019

Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species-induced apoptosis and reduces cell stemness.

Environ Toxicol 2019 Nov 12;34(11):1208-1220. Epub 2019 Jul 12.

Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.

Thymoquinone is a phytochemical compound isolated from Nigella sativa and has various biological effects, including anti-inflammation, antioxidation, and anticancer. Here, we further investigated the anticancer effects and associated molecular mechanism of 2-methyl-5-isopropyl-1,4-benzoquinone (thymoquinone) on human renal carcinoma cell lines 786-O and 786-O-SI3 and transitional carcinoma cell line BFTC-909. Results showed that thymoquinone significantly reduced cell viability, inhibited the colony formation of renal cancer cells, and induced cell apoptosis and mitochondrial membrane potential change in both cancer cells. Read More

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http://dx.doi.org/10.1002/tox.22822DOI Listing
November 2019
9 Reads

Mixed epithelial and stromal tumour with extension to vesicoureteric junction.

Asian J Urol 2019 Jul 30;6(3):302-304. Epub 2018 Jun 30.

Department of Urology, K.S. Hegde Medical Academy, Mangalore, India.

Mixed epithelial and stromal tumour (MEST) is an uncommon renal tumour with a tendency to protrude into the collecting system. We present a 50-year-old woman with a renal tumour extending up to the vesicoureteric junction (VUJ) who was suspected to have an upper tract transitional cell carcinoma for which a nephroureterectomy was performed. Histopathologic examination revealed a MEST arising from the kidney and extending up to the VUJ. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595157PMC
July 2019
7 Reads

Caecal volvulus following left-side laparoscopic retroperitoneal nephroureterectomy.

BMJ Case Rep 2019 Jul 4;12(7). Epub 2019 Jul 4.

Urology, Maidstone and Tunbridge Wells NHS Trust, Maidstone, Kent, UK.

Caecal volvulus is an uncommon cause of intestinal obstruction, with a high associated morbidity and mortality. Caecal volvulus is a very rare complication following retroperitoneal surgery. As such, a high degree of clinical suspicion is warranted post operatively to minimise delay in definitively investigating and managing this condition. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22887
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http://dx.doi.org/10.1136/bcr-2018-228878DOI Listing
July 2019
3 Reads

Genomic Analysis and Treatment Response of a Bladder Urothelial Carcinoma With Sarcomatoid Variant Histology.

Clin Genitourin Cancer 2019 10 25;17(5):e888-e892. Epub 2019 May 25.

Department of Urology, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1016/j.clgc.2019.05.019DOI Listing
October 2019
2 Reads

Incidence of Port Site Metastasis in Laparoscopic Radical Nephroureterectomy: Single-institution Experience.

Urology 2019 Sep 13;131:130-135. Epub 2019 Jun 13.

Department of Urology, the Second Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address:

Objective: To address the incidence and potential risk factors of port site metastasis (PSM) in patients who underwent laparoscopic radical nephroureterectomy (RNU) for upper tract urothelial carcinoma.

Materials And Methods: Between January 2013 and December 2018 laparoscopic RNU were performed in 240 patients at our institution, including 145 with renal pelvic tumor and 135 with ureteral tumor (40 patients have both tumor). Laparoscopies were performed through the transperitoneal approach in 28 patients, and retroperitoneal in 212 patients. Read More

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http://dx.doi.org/10.1016/j.urology.2019.06.003DOI Listing
September 2019
1 Read

Neutrophil-to-Lymphocyte Ratio in Renal Cell Carcinoma Patients.

Folia Med (Plovdiv) 2018 Dec;60(4):553-557

Department of Urology, Haydarpaşa Numune Training and Research Hospital.

Background: Renal cell carcinoma is the third most common cancer after prostate and bladder tumors in urological malignancies. Recently, because of the widespread use of ultrasound and computed tomography, incidental and early stage renal tumors have been encountered more frequently.

Aim: In this study, we evaluated the diagnostic efficacy of neutrophil-to-lymphocyte ratio for the diagnosis of renal cell carcinoma in patients who underwent nephrectomy operation. Read More

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http://dx.doi.org/10.2478/folmed-2018-0037DOI Listing
December 2018
8 Reads

Does preoperative percutaneous nephrostomy insertion worsen upper-tract urothelial cancer oncological outcome? A retrospective single center study.

BMC Urol 2019 Jun 7;19(1):50. Epub 2019 Jun 7.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung, Kaohsiung, Taiwan.

Background: Physicians doubt percutaneous nephrostomy (PCN) insertion on cancer related hydronephrosis patients causes tumor seeding and worse cancer control. In this article, we attempted to determine if preoperative PCN alters cancer control in upper tract urothelial cancer (UTUC) patients.

Methods: Retrospective analysis of UTUC patients in a single center from 2005 to 2015. Read More

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http://dx.doi.org/10.1186/s12894-019-0482-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555991PMC
June 2019
5 Reads

[Markers of stem cells and their prognostic values for urothelial carcinomas of the urinary tract].

Urologiia 2019 Jun(2):40-49

) Department of Pathology of I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

The fundamental question about the origin of cancer stem cells of urothelial carcinomas with luminal remains open. So far, no convincing evidence has been found to determine whether these events occur in a single cell, presumably basal, or are realized in different precursor cells of the urothelium. The potential of a number of potential stem markers as cancer stem cells in urothelial carcinomas and their prognostic significance are currently being investigated. Read More

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June 2019
11 Reads

Diagnosis and Management of a De Novo Urothelial Carcinoma in a Kidney Allograft: A Case Report.

Transplant Proc 2019 May;51(4):1281-1285

Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.

Introduction: Following renal transplantation, the incidence of malignancies is 3-5 times higher than that of healthy individuals. Among other type of cancers, the risk of urological tumors is also elevated. However, only a few cases of de novo transitional cell carcinomas occurring in renal allografts have been reported. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.04.011DOI Listing
May 2019
16 Reads

BK polyomavirus and urothelial carcinoma: Experience at a tertiary care centre in India with review of literature.

Ann Diagn Pathol 2019 Jun 23;40:77-80. Epub 2019 Apr 23.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Introduction: BK polyomavirus is ubiquitous and remains dormant in the urothelial tract, reactivating and replicating in the immunocompromised state especially in the setting of post-renal transplantation where it is believed to be directly oncogenic based on recent reports. Its oncogenic role in the immunocompetent host is controversial. This study aimed to investigate the association of BK polyomavirus in Urothelial Carcinoma. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.04.006DOI Listing
June 2019
4 Reads

[Predictive biomarkers in oncologic uropathology].

Pathologe 2019 May;40(3):264-275

Interdisziplinäre Uroonkologie des Westdeutschen Tumorzentrums Essen, Klinik für Urologie, Innere Medizin (Tumorforschung), Universitätsmedizin Essen, Universität Duisburg-Essen, Essen, Deutschland.

Background: Tumors of the genitourinary system are common. In recent years, our understanding of their molecular background and therefore the number of potential predictive biomarkers has massively increased.

Objectives: The aim of the current work is to give an overview of recent (molecular) developments and predictive biomarkers in urologic oncology and to give a perspective of what might become relevant in the future of the field. Read More

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http://dx.doi.org/10.1007/s00292-019-0606-3DOI Listing
May 2019
2 Reads