40,257 results match your criteria Transitional Cell Carcinoma Involving the Prostate
PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.
Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More
J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.
ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopoietic cells. We used whole-exome sequencing to identify compound heterozygous mutations in ARHGEF1, resulting in the loss of ARHGEF1 protein expression in two primary-antibody-deficient siblings presenting with recurrent severe respiratory tract infections and bronchiectasis. Both ARHGEF1-deficient patients showed an abnormal B cell immunophenotype, with a deficiency in marginal-zone and memory B cells and an increased frequency of transitional B cells. Read More
J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.
Department of Radiology.
Purpose: Approximately 25% of patients with anorectal malformation have tethered cord. The traditional way of determining conus medullaris level on magnetic resonance imaging (MRI) relies on counting vertebrae, which may be challenging due to vertebral numeric variation, segmentation anomalies, as well as transitional vertebral body anatomy. The purpose of this study was to utilize more reliable anatomic landmarks (foramen magnum, conus termination, and the upper limit of the iliac crest) to establish a consistent ratio that may differentiate patients with normal and low-lying conus. Read More
Pneumologie 2018 Dec 3. Epub 2018 Dec 3.
Clinical Research, Thora Tech GmbH, Anwenderzentrum für Medizintechnik, Gießen.
Pulmonary emphysema is characterised by irreversible destruction and enlargement of alveolar structure distal to terminal bronchioles. Small conducting airways < 2 mm in diameter are the major site of chronic airway inflammation and obstruction in COPD patients. 80 - 90 % of the last generation of small conducting airways, the terminal bronchioles, are destroyed in patients with very severe COPD. Read More
J Med Entomol 2018 Dec 1. Epub 2018 Dec 1.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Avenida Pedro Teixeira, Manaus, PMG, Brazil.
The mosquito midgut is divided into two regions named anterior midgut (AMG) and posterior midgut (PMG). The midgut expands intensely after the blood ingestion to accommodate a large amount of ingested food. To efficiently support the bloodmeal-induced changes, the organization of the visceral muscle fibers has significant adjustments. Read More
PLoS Negl Trop Dis 2018 Dec 3;12(12):e0006990. Epub 2018 Dec 3.
Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Background: After being eliminated during the 1950s, dengue reemerged in Brazil in the 1980s. Since then, incidence of the disease has increased, as serotypes move within and between cities. The co-circulation of multiple serotypes contributes to cycles of epidemic and interepidemic years, and a seasonal pattern of transmission is observed annually. Read More
Environ Sci Pollut Res Int 2018 Nov 30. Epub 2018 Nov 30.
Department of Applied Sciences, I.K.G. Punjab Technical University, Jalandhar, Punjab, India.
Vermicompost, recommended inorganic fertiliser, vermiwash and their combinations were used in the present study to know their impact on the germination, growth, yield, oil content and nutritional status in seeds of two varieties of Linum usitatissimum L. LC-54 and LC-2063. Eight treatments, in 48 plots with three replicates, were studied and compared with control. Read More
Urol Case Rep 2019 Mar 23;23:25-26. Epub 2018 Nov 23.
University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.
Primary transitional cell carcinoma arising from the anterior portion of the male urethra is rare, with no recent cases reported in the literature. We present a case of penile TCC with positive urine cytology and a delayed definitive diagnosis. Read More
Can J For Res 2018 Nov 29;48(11):1366-1372. Epub 2018 Aug 29.
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109.
Forests in eastern North America are undergoing rapid compositional changes as they experience novel climate, disturbance, and pest conditions. One striking pattern is the replacement of canopy oaks spp.) by mesic, fire-sensitive, shade-tolerant species like red maple . Read More
Reumatologia 2018 31;56(5):279-284. Epub 2018 Oct 31.
Department of Paediatric Cardiology and Rheumatology, Medical University of Łódź, Poland.
Objectives: The aim of the study was to evaluate the efficacy and long-term safety of tocilizumab treatment in children with systemic-onset juvenile idiopathic arthritis in a single centre.
Material And Methods: The study was based on a retrospective analysis of a cohort of 10 patients with systemic-onset juvenile idiopathic arthritis who were treated with tocilizumab in the period September 2011-July 2017. Their medical records were analysed taking into consideration the effectiveness of tocilizumab treatment and frequency of side effects. Read More
Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944
Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.
To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More
Georgian Med News 2018 Oct(283):171-175
I. Javakhishvili Tbilisi State University, Georgia.
Making appropriate medical decisions in the best interest of the patient and in a line with the patient's autonomy, rights, dignity and plurality of values, are very important. In order to reach those goals and develop patient-oriented health service, Clinical Ethics Committees (CECs) support could make a great contribution. European countries (Netherland, Belgium, Italy, Germany, Norway, UK) are experiencing an exponential rise in the number of CECs as a mechanism to address the new ethical dilemmas in clinical settings, however the practice of CECs are facing barriers in transitional countries in central, eastern, and southeastern Europe. Read More
Scand J Rheumatol 2018 Dec 5:1-5. Epub 2018 Dec 5.
a Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.
Objective: Dermatomyositis (DM) is an idiopathic inflammatory myopathy which often involves the lungs. DM is likely to be associated with aberrant T- and B-cell activation in the pathogenesis because of the proven effectiveness of T- and B-cell-targeted treatments. Assuming that the aberrant activation is reflected by biases in the lymphocyte subset repertoires, we aimed to elucidate these biases, especially in relation to clinical features of DM. Read More
Abdom Radiol (NY) 2018 Dec 4. Epub 2018 Dec 4.
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul, 135-710, Republic of Korea.
Purpose: To determine the differential features of inflammatory myofibroblastic tumor (IMT) and intrahepatic cholangiocarcinoma (ICC) manifesting as target appearance on gadoxetic acid-enhanced MRI.
Methods: Twenty-seven patients with 36 IMTs (1.2-6. Read More
CMAJ Open 2018 Oct-Dec;6(4):E587-E593. Epub 2018 Dec 3.
Department of Medicine (Lam, Abrams, Okrainec), University of Toronto; Division of General Internal Medicine (Abrams, Okrainec), University Health Network; Biostatistics Research Unit (Matelski), University Health Network, Toronto, Ont.
Background: Follow-up with a primary care provider within 1-2 weeks of discharge from hospital has been associated with reduced readmissions. We sought to determine appointment attendance with primary care providers postdischarge and identify factors associated with attendance.
Methods: We conducted a retrospective cohort study involving general medicine patients who had been discharged from hospital between Sept. Read More
Philos Trans R Soc Lond B Biol Sci 2018 Dec 3;374(1764). Epub 2018 Dec 3.
Instituto de Ciencias Ambientales (ICAM), Universidad de Castilla-La Mancha, Toledo, Spain.
Under global change, the ion concentration of aquatic ecosystems is changing worldwide. Many freshwater ecosystems are being salinized by anthropogenic salt inputs, whereas many naturally saline ones are being diluted by agricultural drainages. This occurs concomitantly with changes in other stressors, which can result in additive, antagonistic or synergistic effects on organisms. Read More
Neoplasma 2018 Sep 4. Epub 2018 Sep 4.
Division of Radiation Oncology, European Institute of Oncology, Milan, Italy.
The aim of our study was to retrospectively report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed. The primary endpoint was to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer the start of a systemic therapy. Read More
Pol J Pathol 2018 ;69(3):234-242
Androgen receptor (AR) activation plays an important role in the promotion and progression of urothelial tumorigenesis. Also, dysregulation of the Wnt/β-catenin signaling pathway has also been linked to bladder cancer growth. However, cross talk between the two pathways in remains unclear in bladder cancer. Read More
Pol J Pathol 2018 ;69(3):226-233
Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More
PLoS One 2018 30;13(11):e0208244. Epub 2018 Nov 30.
Laboratorio de Ciencias del Mar, Universidad Peruana Cayetano Heredia, Lima, Perú.
The biogeography of the Peruvian Eastern Pacific coast has been described based on oceanographic parameters and qualitative species occurrence data. This has generated disagreement about the limits and existence of different biogeographic units. In this study, the distribution of rocky-shore macrobenthic communities were recorded over 41 sites along the Peruvian coastline (3. Read More
ACS Appl Mater Interfaces 2018 Nov 30. Epub 2018 Nov 30.
During the formulation of therapeutic monoclonal antibodies (mAbs), nonionic surfactants are commonly added to attenuate structural rearrangement caused by adsorption/desorption at interfaces during processing, shipping and storage. We examined the adsorption of a mAb (COE-3) at the SiO2/water interface in the presence of pentaethylene glycol monododecyl ether (C12E5), polysorbate 80 (PS80-20EO) and a polysorbate 80 analogue with 7 ethoxylates (PS80-7EO). Spectroscopic ellipsometry (SE) was used to follow COE-3 dynamic adsorption and neutron reflection (NR) was used to determine interfacial structure and composition. Read More
Clin Neuropathol 2018 Nov 30. Epub 2018 Nov 30.
Solitary fibrous tumor/hemangiopericytoma seldom arises from the optic nerve sheath. Herein, we describe the clinical, radiological, and histological findings of a solitary fibrous tumor/hemangiopericytoma arising from the optic nerve sheath and occupying the optic canal. The diagnosis is challenging both clinically and histologically as it clinically simulates a commoner lesion, i. Read More
BJU Int 2018 Nov 30. Epub 2018 Nov 30.
Department of Radiology and Nuclear Medicine, St Gallen Cantonal Hospital, St Gallen, Switzerland.
Objectives: To identify predictive parameters of different treatment outcomes after prostatic artery embolization (PAE) in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.
Patients And Methods: A post-hoc analysis of data derived from the 48 patients undergoing PAE in a randomized, open label, non-inferiority trial was performed. Relative changes in the International Prostate Symptoms Score (IPSS), absolute changes in maximum flow rate, and relative changes in MRI-assessed prostate volume from baseline to 12 weeks were defined as the outcomes measures of interest. Read More
J Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.
Department of Clinical Immunology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Purpose: We aimed to report the clinical manifestations and immunological features of activated phosphatidylinositol 3-kinase δ syndrome 1 (APDS1) in a Chinese cohort. Moreover, we investigated the efficacy and safety of rapamycin therapy for Chinese patients with APDS1.
Methods: Fifteen Chinese patients with APDS1 from 14 unrelated families were enrolled in this study. Read More
Nat Commun 2018 Nov 29;9(1):5055. Epub 2018 Nov 29.
Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, 97239, OR, USA.
Membrane proteins are universal signal decoders. The helical transmembrane segments of these proteins play central roles in sensory transduction, yet the mechanistic contributions of secondary structure remain unresolved. To investigate the role of main-chain hydrogen bonding on transmembrane function, we encoded amide-to-ester substitutions at sites throughout the S4 voltage-sensing segment of Shaker potassium channels, a region that undergoes rapid, voltage-driven movement during channel gating. Read More
J Neurosurg Spine 2018 Oct 1:1-9. Epub 2018 Oct 1.
OBJECTIVEProximal junctional kyphosis (PJK) and failure (PJF) are potentially catastrophic complications that result from abrupt changes in stress across rigid instrumented and mobile non-fused segments of the spine (transition zone) after adult spinal deformity surgery. Recently, data have indicated that extension (widening) of the transitional zone via use of proximal junctional (PJ) semi-rigid fixation can mitigate this complication. To assess the biomechanical effectiveness of 3 semi-rigid fixation constructs (compared to pedicle screw fixation alone), the authors performed cadaveric studies that measured the extent of PJ motion and intradiscal pressure changes (ΔIDP). Read More
J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.
OBJECTIVEThe trigeminal root entry zone (TREZ) is a transitional zone between the central nervous system (CNS) and peripheral nervous system (PNS), adjacent to the brainstem. Microvascular compression of the TREZ has been considered to be the primary etiology in most cases of trigeminal neuralgia (TN), but whether epigenetic regulation is involved in the pathogenesis of TN is still unclear. Therefore, this study was designed to investigate the epigenetic regulation of histone H3 acetylation in the TREZ in an animal model of TN. Read More
J Theor Biol 2018 Nov 26. Epub 2018 Nov 26.
Center for Mathematical Modeling and Data Science, Osaka University, Osaka, Japan.
The transcription factor NF-κB performs various cell functions, such as regulating proliferation and differentiation and blocking apoptosis, by inducing the expression of multiple genes. The shuttling of NF-κB between the cytoplasm and nucleus is involved in its transcriptional activity in the canonical NF-κB pathway. The transcription of the NF-κB target genes is regulated by the phosphorylation of both IκBα and the RelA subunit of NF-κB, suggesting that these phosphorylation events are crucial for the oscillation. Read More
Am J Sports Med 2018 Nov 29:363546518812416. Epub 2018 Nov 29.
Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA.
Background:: The ulnar collateral ligament (UCL) microstructural organization and collagen fiber realignment in response to load are unknown.
Purpose/hypothesis:: The purpose was to describe the real-time microstructural collagen changes in the anterior bundle (AB) and posterior bundle (PB) of the UCL with tensile load. It was hypothesized that the UCL AB is stronger and stiffer with more highly aligned collagen during loading when compared with the UCL PB. Read More
Bull Exp Biol Med 2018 Dec 28;166(2):274-278. Epub 2018 Nov 28.
N. N. Priorov Central Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Moscow, Russia.
Structural dynamics of the fibrous basis of the reparative regenerate during spontaneous skin wound healing comprises multiple stages, it successively transforms from one organization level to another more complex level, forms a multilevel 3D structure including molecular, supramolecular, fibrillar, fiber, and tissue elements. The formed reparative regenerate is integrated with the preserved skin, together they have common fibrous basis consisting of three parts that are different in organization of fibrous structures: atypical (central), tissue organospecific (peripheral), and transitional. Read More
Cardiovasc Eng Technol 2018 Nov 28. Epub 2018 Nov 28.
Department of Mechanical Engineering, University of Birmingham, Birmingham, B15 2TT, UK.
Purpose: This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries.
Methods: Eight coronary arteries were divided into proximal, middle and distal test specimens. Specimens underwent uniaxial extension up to 3 mm. Read More
Food Funct 2018 Nov 29. Epub 2018 Nov 29.
Nutrition and Food Science Area, Faculty of Pharmacy, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 - Burjassot (Valencia), Spain.
Human milk (HM) is the exclusive food during the first 4-6 months of an infant's life. Breastfeeding has been related to significant health benefits for infants, and hence it is of interest to study the bioactive compounds present in HM, such as sterols (cholesterol being the most abundant). The aim of this study was to determine the contents of sterols (cholesterol, desmosterol, lathosterol, lanosterol, campesterol, stigmasterol and β-sitosterol) in 10 pools of colostrum, transitional milk, and 1, 3 and 6 month HM obtained from Spanish volunteers from two different geographical areas (coastal and central) and to estimate the intake and bioaccessibility (BA) of sterols in order to ascertain the fate of sterols after digestion. Read More
J Can Acad Child Adolesc Psychiatry 2018 Nov 1;27(4):228-235. Epub 2018 Nov 1.
East Metro Youth Services, Toronto, Ontario.
Transitions between hospital and community services and from child and adolescent to adult services have been identified as a priority for improvement in the child and adolescent mental health and addictions sector across Canada and internationally. Despite widespread recognition of the issue, there is very little in the way of evidence to guide policy and programming to improve transitions. Transition support workers have been identified as a promising intervention to facilitate successful transitions, and innovative programs involving transition workers are currently operating in the Canadian mental health sector. Read More
Vet Sci 2018 Nov 27;5(4). Epub 2018 Nov 27.
School of Veterinary Medicine, University of California-Davis, 1 Garrod Drive, Davis, CA 95616, USA.
Lower urinary tract neoplasia in companion animals is a debilitating and often life-threatening disease. Tumors of the bladder, urethra, and prostate often occur independently, although extension of these tumors into adjacent regions of the lower urinary tract is documented frequently. The most common lower urinary tract tumor in dogs and cats is transitional cell carcinoma (TCC). Read More
J Gerontol Nurs 2018 Dec;44(12):45-52
The purpose of the current study was to determine the relationship between chronic condition symptoms and treatment burden in older adults transitioning from skilled nursing facilities to home. Treatment burden is defined as the burden associated with adhering to a prescribed chronic condition self-management regimen. Analysis of correlations between chronic condition symptoms and treatment burden revealed that symptoms and treatment burden are positively correlated (p < 0. Read More
Reprod Health Matters 2018 Dec;26(52):1517543
k Lecturer, Institute for Gender and Development Studies, Mona Campus, University of the West Indies , Kingston , Jamaica.
Limited research has examined lesbian and bisexual women's sexual health practices in the Caribbean, where lesbian and bisexual women experience sexual stigma that may reduce sexual healthcare utilisation. We conducted a sequential multi-method research study, including semi-structured individual interviews (n = 20) and a focus group (n = 5) followed by a cross-sectional survey (n = 205) with lesbian and bisexual women in Kingston, Montego Bay, and Ocho Rios, Jamaica. Binary logistic analyses and ordinal logistic regression were conducted to estimate the odds ratios for social-ecological factors associated with lifetime STI testing, sex work involvement, and the last time of STI testing. Read More
Handb Clin Neurol 2018 ;158:371-377
Transitional Rehabilitation Program, Queensland, Spinal Cord Injuries Service, Brisbane, Australia. Electronic address:
Classification of athletes for para sport is a complex process, and provides the necessary structure for competition. Classification systems aim to ensure that para athletes achieve sporting excellence. By minimizing the effect of the impairment on sports performance, classification systems ensure para sport is not dominated by those athletes with the least impairment, but rather athletic excellence is the key determinant of success. Read More
Zhonghua Yi Xue Za Zhi 2018 Nov;98(43):3524-3527
Super-minimally Invasive Medicals, Shanghai International Medical Center, Shanghai 201210, China.
To explore the effect of microwave ablation on thyroid nodules cell activity by the reaction of key enzyme of cell activation. From November 2017 to February 2018, 104 patients with 120 thyroid nodules underwent ultrasound-guided microwave ablation at Super-minimally Invasive Medicals, Shanghai International Medical Center, aged 14-55 years, 42 males and 62 females.Twice core needle biopsy were performed before and after thermal ablation. Read More
Ear Nose Throat J 2018 Oct-Nov;97(10-11):E32-E35
Department of Otolaryngology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama 380-8550, Japan.
Lacrimal sac tumors are rare and difficult to diagnose. We present a case of coexisting lacrimal sac adenocarcinoma and transitional cell carcinoma in a 73-year-old woman who presented with swelling of the inner canthus. Biopsy identified the growth as an adenocarcinoma. Read More
J Contemp Brachytherapy 2018 Oct 31;10(5):483-485. Epub 2018 Oct 31.
Radiotherapy Unit ARNAS-Civico Palermo.
Transitional cell carcinoma is a very rare histological subtype of endometrial cancer, with only 18 cases described in literature. Ovary represents the most common site where it accounts for 2% of all ovarian cancers. Due to the rarity of this disease, current management is controversial and includes various approaches, mostly described in the adjuvant setting, both radiotherapy and chemotherapy alone or in combination. Read More
Clin Proteomics 2018 16;15:36. Epub 2018 Nov 16.
2Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Number 128, Shenyang Road, Shanghai, 200011 China.
Background: Natural menopause is always accompanied by specific signs and symptoms, suggesting physiological changes in this peoriod. However, no systematic study has assessed the changes at molecular level in the ovaries during the menopausal transition so far. This study integrated quantitative proteome and acetyl-proteome to comprehensively uncover the changes of ovarian protein and protein-acetylation profiles in this transitional period. Read More
Environ Sci Technol 2018 Nov 27. Epub 2018 Nov 27.
Minerals and transitional metal oxides of earth-abundant elements are desirable catalysts for in situ chemical oxidation in environmental remediation. However, catalytic activation of peroxydisulfate (PDS) by manganese oxides was barely investigated. In this study, one-dimension manganese dioxides (α- and β-MnO2) were discovered as effective PDS activators among the diverse manganese oxides for selective degradation of organic contaminants. Read More
ACS Appl Mater Interfaces 2018 Nov 27. Epub 2018 Nov 27.
Heterostructures involving layered two dimensional (2D) transitional metal dichalcogenides (TMDCs) are not only fundamentally interesting to explore emerging properties at atomically thin limit, but also technically important to achieve novel optoelectronic devices. However, achieving tunable optoelectronic properties and clarifying interlayer processes (charge transfer, energy transfer) in 2D heterostructures remain to be part of the key challenges so far. Here, by fabricating heterostructures of graphene and monolayer TMDCs (n-type MoS2 and p-type WSe2), we demonstrate both electrically and optically tunable response from the heterostructure, revealing the critical interface process between graphene and TMDCs. Read More
Arch Dis Child Fetal Neonatal Ed 2018 Nov 26. Epub 2018 Nov 26.
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Objective: To assess the neurological function of newborn infants in the first minutes after birth using EEG.
Design And Patients: We obtained electroencephalography (EEG) recordings in term infants following elective caesarean section. After delivery, disposable EEG electrodes were attached to the infants' scalp over the frontal and central regions bilaterally and EEG was recorded for 10 min. Read More
Urol Oncol 2018 Nov 24. Epub 2018 Nov 24.
Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. Electronic address:
Objectives: Serum γ-glutamyltransferase (GGT) is reportedly associated with prognosis in patients with various malignancies. However, the prognostic role of GGT is unknown among patients with advanced urothelial carcinoma (aUC). This study was designed to examine the prognostic role of serum GGT in patients with aUC. Read More
JAMA Pediatr 2018 Nov 26. Epub 2018 Nov 26.
Division of Fetal and Transitional Medicine, Children's National Health System, Washington, DC.
Importance: The evolution of fetal brain injury by Zika virus (ZIKV) infection is not well described.
Objectives: To perform longitudinal neuroimaging of fetuses and infants exposed to in utero maternal ZIKV infection using concomitant magnetic resonance imaging (MRI) and ultrasonography (US), as well as to determine the duration of viremia in pregnant women with ZIKV infection and whether the duration of viremia correlated with fetal and/or infant brain abnormalities.
Design, Setting, And Participants: A cohort of 82 pregnant women with clinical criteria for probable ZIKV infection in Barranquilla, Colombia, and Washington, DC, were enrolled from June 15, 2016, through June 27, 2017, with Colombian women identified by community recruitment and physician referral and travel-related cases of American women recruited from a Congenital Zika Program. Read More
J Neuroimmunol 2018 Nov 16;326:49-54. Epub 2018 Nov 16.
Unidade de Gestão Operacional de Citometria, Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Praceta Mota Pinto, 3001-301 Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculdade de Medicina, Universidade de Coimbra, Polo III - Health Sciences Campus Azinhaga Santa Comba, Celas, 3000-548 Coimbra, Portugal; Escola Superior de Tecnologia da Saúde de Coimbra, Rua 5 de Outubro, 3046-854 Coimbra, Portugal. Electronic address:
Our aim was to quantify circulating B cell subsets; immature/transitional, naïve, CD27 and CD27 memory cells and plasmablasts, in relapsing-remitting multiple sclerosis patients treated with IFN-β. The most relevant findings were a significant increase of plasmablasts and a decrease of immature/transitional B cells, resulting in a decreased ratio between those cells in relapse RRMS, together with an increase of CD27 and CD27IgM memory B cell subsets in both phases of the disease. These alterations point to an active B cell response, particularly in relapse, and the above referred ratio could constitute a good biomarker of relapse in patients that underwent IFN-β treatment. Read More
Neurosurgery 2018 Nov 23. Epub 2018 Nov 23.
Spine Research LLC, Winchester, Massachusetts.
Oper Neurosurg (Hagerstown) 2018 Nov 24. Epub 2018 Nov 24.
Department of Neurosurgery Shinshu University School of Medicine Matsumoto, Japan.
Mol Neurobiol 2018 Nov 24. Epub 2018 Nov 24.
Neurobiology of Aging, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CABA, Argentina.
Adolescence is a transitional period from childhood to adulthood characterized by puberty and brain maturation involving behavioral changes and environmental vulnerability. Diet is one of the factors affecting brain health, potentially leading to long-lasting effects. Hence, we studied the impact of early exposure (P21-60) to a high-fat diet (HFD) on mouse hippocampus, analyzing inflammation, adult neurogenesis, dendritic spine plasticity, and spatial memory. Read More