Search Our Scientific Publications & Authors

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Urology, East Kent Hospitals University NHS Foundation Trust, Canterbury, UK.

Upper tract urothelial carcinoma represents a small proportion (5%-10%) of all urothelial cancers. Although there are several management options, in undifferentiated or high-risk cases, surgery in the form of nephroureterectomy is the gold standard. Horseshoe kidney is the most common congenital renal fusion anomaly affecting 1 in 400-600 patients. Read More

Indian J Urol 2021 Apr-Jun;37(2):169-172. Epub 2021 Apr 1.

Department of Urology and Renal Transplant, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Upper tract urothelial carcinoma (UTUC) of the renal pelvis and the ureter is incidentally detected in a small proportion of cases. However, the majority of UTUC cases present with hematuria, flank pain, and clot colic. Typical imaging features include hydronephrosis of the kidney (s) due to obstruction by the mass with a soft-tissue lesion that typically shows low-grade enhancement with or without a filling defect. Read More

Int J Surg Case Rep 2021 Jun 1;83:106057. Epub 2021 Jun 1.

Department of Urology, Aleppo University Hospital, Aleppo, Syria. Electronic address:

Introduction And Importance: Bladder diverticula are mucosal outpunching of the bladder without a muscle layer. It could be detected incidentally or by giving symptoms of its complications.

Case Presentation: A 59-year-old male patient presented with painless gross hematuria. Read More

Orbit 2021 Jun 2:1-5. Epub 2021 Jun 2.

Department of Ophthalmology, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.

Orbital metastasis of urothelial carcinoma is very rare; only 22 cases have been documented. In this case report, we describe a patient 1 month status post transurethral resection of urothelial carcinoma who presented with a clinical picture suggestive of orbital cellulitis. However, neither broad-spectrum antibiotics nor a subsequent trial of methylprednisolone was effective at relieving the patient's symptoms. Read More

J Am Coll Radiol 2021 May;18(5S):S126-S138

Specialty Chair, University of Alabama at Birmingham, Birmingham, Alabama.

Urothelial cancer is the second most common cancer, and cause of cancer death, related to the genitourinary tract. The goals of surveillance imaging after the treatment of urothelial cancer of the urinary bladder are to detect new or previously undetected urothelial tumors, to identify metastatic disease, and to evaluate for complications of therapy. For surveillance, patients can be stratified into one of three groups: 1) nonmuscle invasive bladder cancer with no symptoms or additional risk factors; 2) nonmuscle invasive bladder cancer with symptoms or additional risk factors; and 3) muscle invasive bladder cancer. Read More

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Sarcomatoid urothelial carcinoma is a rare aggressive malignant neoplasm of the urinary bladder. It usually presents at an advanced stage and thus carries a poor prognosis. These tumours are usually managed with multimodal therapies such as cystectomy and chemotherapy. Read More

Eur Urol Focus 2021 Mar 24. Epub 2021 Mar 24.

Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Background: The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.

Objective: To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).

Design, Setting, And Participants: This was a retrospective study including 1214 patients from 21 centers who underwent ureterorenoscopy (URS) with biopsy followed by radical nephroureterectomy (RNU) for nonmetastatic UTUC between 2000 and 2017. Read More

Arch Ital Urol Androl 2021 Mar 19;93(1):71-76. Epub 2021 Mar 19.

Urology Department, General Hospital of Athens "G. Gennimatas", Athens.

This collection of cases describes some unusual urological tumors and complications related to urological tumors and their treatment. Case 1: A case of uretero-arterial fistula in a patient with long-term ureteral stenting for ureteral oncological stricture and a second case associated to retroperitoneal fibrosis were described. Abdominal CT, pyelography, cystoscopy were useful to show the origin of the bleeding. Read More

Curr Opin Urol 2021 05;31(3):220-225

Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan.

Purpose Of Review: To systematically review the most recent evidence on the role of surgery in patients with urothelial carcinoma of bladder and lymph node metastasis.

Recent Findings: Patients with urothelial carcinoma of bladder and lymph node metastasis have a poor prognosis. The mainstay treatment for these patients is systemic chemotherapy. Read More

BMJ Case Rep 2021 Mar 10;14(3). Epub 2021 Mar 10.

Department of Urology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

A 75-year-old man was referred to our urology service with painless haematuria. The delayed phase on a subsequent computed tomography (CT) abdomen and pelvis showed a filling defect in the left renal pelvicalyceal system, suspicious for a transitional cell carcinoma. The patient underwent ureteroscopic biopsy suggestive of a papillary neoplasia, before progressing to a laparoscopic radical left nephrouretectomy. Read More

Int J Surg Case Rep 2021 Apr 3;81:105717. Epub 2021 Mar 3.

Urology Department, Hopital La Rabta, Tunis, Tunisia.

Introduction And Importance: Spontaneous rupture of the urinary bladder is rare but potentially severe. It is unusually related to bladder tumours. The morbidity and mortality rate are very high in these groups of patients. Read More

Urol Case Rep 2021 Jul 11;37:101607. Epub 2021 Feb 11.

Apollo Hospitals, Indore, India.

We are reporting a very rare case in the current era of modern diagnostics of an incidentally detected Transitional Cell Carcinoma(TCC) renal pelvis, detected pathologically when Right laparoscopic radical nephrectomy specimen of lower pole mass(RCC) was processed, with no prior suspicion of TCC clinically or pre-operative imaging. A 75-year-old female with 4 × 4cm strongly enhancing lower pole renal mass on CTscan underwent a Laparoscopic Radical Nephrectomy. Surprisingly histopathological examination revealed a focus of low-grade TCC, arising from renal pelvis, completely separate from lower pole mass which was a clear cell RCC. Read More

Hinyokika Kiyo 2021 Feb;67(2):67-71

The Department of Urology, Kansai Electric Power Hospital.

Ureteral metastases from prostate cancer are uncommon. We report a case of prostate cancer with bilateral ureteral metastases. A 76-year-old man visited our hospital because of serum prostate specific antigen (PSA) level of 40. Read More

Int J Urol 2021 05 16;28(5):593-597. Epub 2021 Feb 16.

Department of Urology, Mayo Clinic Hospital, Phoenix, Arizona, USA.

Objectives: To compare ureteroenteric stricture rates after radical cystectomy in patients who undergo an intracorporeal urinary diversion versus other surgical approaches.

Methods: We retrospectively reviewed health records of all patients who underwent cystectomy with urinary diversion at Mayo Clinic Hospital (Phoenix, AZ, USA) from 1 January 2007 through 1 January 2018. Ureteroenteric stricture was identified by surveillance imaging. Read More

Eur Urol Oncol 2021 Feb 11. Epub 2021 Feb 11.

Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Electronic address:

Given the high risk of systemic relapse following initial therapy for muscle-invasive bladder cancer (MIBC), improved pretreatment staging is needed. We evaluated the incremental value of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after standard conventional staging, in the largest cohort of MIBC patients to date. This is a retrospective analysis of 711 consecutive patients with invasive urothelial bladder cancer who underwent staging contrast-enhanced CT (chest and abdomen) and FDG-PET/CT in a tertiary referral center between 2011 and 2020. Read More

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Department of Urology, Northern Care Alliance NHS Group, Manchester, UK.

A 58-year-old woman with a previous clam ileocystoplasty was referred to the urology department for the investigation of haematuria. CT urogram showed a large left-sided soft tissue mass arising from the bladder. Histological analysis of the shavings from transurethral resection revealed a G3pT2 transitional cell carcinoma and T4N1Mx adenocarcinoma. Read More

J Endourol Case Rep 2020 29;6(4):536-539. Epub 2020 Dec 29.

Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey, USA.

Renal cell carcinoma (RCC) originates from the renal parenchyma, whereas transitional cell carcinoma (TCC) originates from the renal urothelium. Although renal pelvis TCC is relatively rare in terms of urologic malignancies, it is the most common tumor originating in renal pelvis. A 75-year-old woman presented with gross hematuria found to have a filling defect in the renal pelvis with retrograde pyelogram and cytology showed clusters of urothelial cells, with imaging suspicious for TCC. Read More

Medicina (Kaunas) 2021 Jan 8;57(1). Epub 2021 Jan 8.

Radiology Department, Hospital Clinic, University of Barcelona (UB), 08036 Barcelona, Spain.

The detection of a renal mass is a relatively frequent occurrence in the daily practice of any Radiology Department. The diagnostic approaches depend on whether the lesion is cystic or solid. Cystic lesions can be managed using the Bosniak classification, while management of solid lesions depends on whether the lesion is well-defined or infiltrative. Read More

Invest New Drugs 2021 Jun 6;39(3):812-820. Epub 2021 Jan 6.

City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

Background: Until the advent of T cell check point inhibitors standard second-line therapy for patients with metastatic urothelial cancer (mUC) was undefined. Histone deacetylase inhibitors (HDACi) have anti-cancer activity in a variety of tumor models including modulation of apoptosis in bladder cancer cell lines. We evaluated the efficacy and toxicity of the HDACi vorinostat in patients with mUC failing first-line platinum-based therapy either in the adjuvant/neoadjuvant setting or for recurrent/advanced disease. Read More

Medicina (Kaunas) 2020 Dec 17;56(12). Epub 2020 Dec 17.

Department of Radiology, University of Trieste, ASUGI, Cattinara Hospital, 34139 Trieste, Italy.

Urothelial carcinoma (UC) is the fourth most frequent tumor in Western countries and upper tract urothelial carcinoma (UTUC), affecting pyelocaliceal cavities and ureter, accounts for 5-10% of all UCs. Computed tomography urography (CTU) is now considered the imaging modality of choice for diagnosis and staging of UTUC, guiding disease management. Although its specificity is very high, both benign and malignant diseases could mimic UTUCs and therefore have to be well-known to avoid misdiagnosis. Read More

N Z Med J 2020 12 18;133(1527):71-82. Epub 2020 Dec 18.

Clinical Writer and Analyst, Canterbury Initiative, Canterbury District Health Board, Christchurch.

Aim: To evaluate prospectively a clinical pathway for investigation of haematuria that involves an initial screening using a urinary biomarker of bladder cancer (Cxbladder Triage™ (CxbT)) in combination with either a renal ultrasound or a computed tomography imaging. Only test-positive patients are referred for specialist assessment and flexible cystoscopy.

Methods: The clinical outcomes of 884 patients with haematuria who presented to their general practitioner were reviewed. Read More

BMJ Case Rep 2020 Nov 4;13(11). Epub 2020 Nov 4.

James Paget University Hospital, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK.

A 60-year-old man recently admitted for bipedal oedema, endocarditis and a persistently positive COVID-19 swab with a history of anticoagulation on rivaroxaban for atrial fibrillation, transitional cell carcinoma, cerebral amyloid angiopathy, diabetes and hypertension presented with sudden onset diplopia and vertical gaze palsy. Vestibulo-ocular reflex was preserved. Simultaneously, he developed a scotoma and sudden visual loss, and was found to have a right branch retinal artery occlusion. Read More

Am J Case Rep 2020 Oct 19;21:e926630. Epub 2020 Oct 19.

Department of Radiology, National Defense Medical College, Tokorozawa, Saitama, Japan.

BACKGROUND Acquired cystic disease-associated renal cell carcinoma (ACD-associated RCC), which was added to the 2016 World Health Organization classification, is the most common subtype of RCC in patients undergoing long-term dialysis. ACD-associated RCC is underrecognized and reports of computed tomography (CT) and magnetic resonance imaging findings for the lesion are sparse. Similar to urothelial carcinoma, ACD-associated RCC is poorly to slightly enhanced on dynamic CT. Read More

BMC Vet Res 2020 Oct 13;16(1):388. Epub 2020 Oct 13.

Department of Small Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA.

Background: This is the first case report description, to our knowledge, of a cranial mediastinal mass (suspected thymoma) causing orthostatic hypotension in a dog.

Case Presentation: A Labrador Retriever presented for urethral stent placement during cystoscopy secondary to transitional cell carcinoma diagnosis. During anesthesia, the patient had unexpected severe and poorly-responsive hypotension following a shift in position. Read More

J Urol 2021 03 6;205(3):686-692. Epub 2020 Oct 6.

Department of Urology, Kyorin University School of Medicine, Tokyo, Japan.

Purpose: The Vesical Imaging Reporting and Data System (VI-RADS) was launched in 2018 to standardize reporting of magnetic resonance imaging for bladder cancer. This study aimed to prospectively validate VI-RADS using a next-generation magnetic resonance imaging scanner and to investigate the usefulness of denoising deep learning reconstruction.

Materials And Methods: We prospectively enrolled 98 patients who underwent bladder multiparametric magnetic resonance imaging using a next-generation magnetic resonance imaging scanner before transurethral resection of bladder tumor. Read More

J Vet Med Sci 2021 Apr 22;83(4):695-704. Epub 2020 Sep 22.

"La Cittadina" Foundation for Veterinary Studies and Research, Road to the "La cittadina", 26014, Romanengo (Cr), Italy.

The aims of this pilot study were to evaluate the feasibility and efficacy of high-dose hypofractionated volumetric modulated arc radiotherapy (VMAT) applied to whole pelvic region radiotherapy (WPRT) with multilevel simultaneous integrated boost (MLSIB) combined with piroxicam and chemotherapy for the treatment of canine transitional cell carcinoma (TCC) of the lower urinary tract with muscle invasion TCC. Twelve dogs were enrolled, according to stage, in two groups: group 1, TCC confined to the urinary tract; group 2, TCC with metastasis. The planning target volume dose was tailored from 36 to 42 Gy in 6 fractions. Read More

JBJS Case Connect 2020 Jul-Sep;10(3):e2000098

1Wright State University College of Medicine, Dayton, Ohio 2Department of Orthopedic Surgery, Wright State University, Miami Valley Hospital, Dayton, Ohio 3Department of Orthopedics, Dayton VA Medical Center, Dayton, Ohio.

Case: A 64-year-old man suffered a pathologic left femoral neck fracture. Biopsy demonstrated metastatic urothelial cancer with a nonmuscle invasive bladder cancer primary confirmed by cystoscopy. The patient underwent hemiarthroplasty, chemotherapy, radiation, and eventually, a conversion to total hip arthroplasty. Read More

Medicine (Baltimore) 2020 Sep;99(38):e22329

Department of Urology.

Rationale: A supernumerary kidney is an extremely rare renal anomaly. Currently, <100 cases are reported in the literature. There are only 2 right unilateral supernumerary kidneys reported in the literature thus far, but no confirmed cases of urothelial carcinoma in supernumerary kidneys. Read More

Urologe A 2020 Oct;59(10):1265-1274

Abteilung für Urologie, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Deutschland.

Upper urinary tract urothelial cell carcinoma (UTUC) is a rare entity. The incidence in Germany is approximately 2/100,000 with a ratio between women and men of 1:2.5. Read More

J Urol 2021 02 16;205(2):392-399. Epub 2020 Sep 16.

Fundació Puigvert, Department of Urology, Autonomous University of Barcelona, Barcelona, Spain.

Purpose: We report the reliability of computerized tomography urography and ureteroscopy in the diagnosis and management of upper tract urothelial carcinoma.

Materials And Methods: From 2015 to November 2018 we prospectively collected and retrospectively analyzed 244 cases of ureteroscopy with available preoperative computerized tomography urography. Computerized tomography urography was categorized as positive, suspicious, unlikely and negative. Read More