1,900 results match your criteria Transitional Cell Carcinoma Imaging


High Response Rates to Neoadjuvant Chemotherapy in High Grade Upper Tract Urothelial Carcinoma.

Urology 2019 Mar 28. Epub 2019 Mar 28.

Department of Urology, NYU Langone Health, New York, NY. Electronic address:

Objectives: To evaluate the impact of cisplatin-based neoadjuvant chemotherapy (NAC) in patients who underwent nephroureterectomy for high grade (HG) upper tract urothelial carcinoma (UTUC).

Methods: Retrospective review was conducted of patients with HG UTUC from 2011 to 2017 who underwent nephroureterectomy at two institutions. Patients with eGFR > 50 mL/min/1. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.058DOI Listing
March 2019
1 Read

Staging a great escape -Incidentally detected renal urothelial carcinoma with extensive squamous metaplasia presenting as pyonephrosis.

J Cancer Res Ther 2019 Mar;15(Supplement):S159-S162

Department of Surgery, Maulana Azad Medical College, New Delhi, India.

Incidentally, detected upper urinary tract urothelial carcinoma is a rare entity. We report the case of a 70-year-old female patient who presented with flank pain, pyuria, fever, and a unilateral nonfunctioning kidney with nephrolithiasis and pyonephrosis on pyelography. Routine imaging failed to identify a mass lesion. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_628_17DOI Listing
March 2019
1 Read

The Impact of Narrow Band Imaging in the Detection and Resection of Bladder Tumor in Transitional Cell Carcinoma of the Bladder: A Prospective, Blinded, Sequential Intervention Randomized Controlled Trial.

Urology 2019 Feb 26. Epub 2019 Feb 26.

Department of Urology, Christian Medical College, Vellore, Tamil Nadu, India.

Objective: To determine the impact of Narrow Band Imaging (NBI) in detection and resection of tumors during transurethral resection of bladder cancer.

Materials And Methods: This was a single center randomized prospective interventional study with a sequential intervention design. Patients with bladder tumors were randomized into 2 arms where they were resected under white light (WL) first followed by NBI in arm A, or NBI followed by WL in arm B. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.039DOI Listing
February 2019
1 Read

Differentiating intrapulmonary metastases from different primary tumors via quantitative dual-energy CT based iodine concentration and conventional CT attenuation.

Eur J Radiol 2019 Feb 14;111:6-13. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.

Materials And Methods: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183045
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http://dx.doi.org/10.1016/j.ejrad.2018.12.015DOI Listing
February 2019
9 Reads

Imaging of Unusual Renal Tumors.

Curr Urol Rep 2019 Jan 21;20(1). Epub 2019 Jan 21.

Department of Radiology, University of Miami/Miller School of Medicine, 1611 NW 12th Avenue, Miami, FL, 33136, USA.

Purpose Of Review: Renal masses are a wide entity and a common finding in clinical practice. Detection of these masses has increased in the last years, yet mortality rates have slightly decreased.

Recent Findings: According to the World Health Organization classification, there are 8 types, 51 subtypes, and a lot more subsequent subclassifications of renal tumors. Read More

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http://link.springer.com/10.1007/s11934-019-0867-7
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http://dx.doi.org/10.1007/s11934-019-0867-7DOI Listing
January 2019
8 Reads

[Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.15654/TPK-180554
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http://dx.doi.org/10.15654/TPK-180554DOI Listing
October 2018
15 Reads

Recurrent oligometastatic transitional cell bladder carcinoma: is there room for radiotherapy?

Neoplasma 2019 Jan 4;66(1):160-165. Epub 2018 Sep 4.

Division of Radiation Oncology, European Institute of Oncology, Milan, Italy.

This paper presents a retrospective report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed, with the primary endpoint to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer commencement of systemic therapy. The inclusion criteria were: patients who received RT without other local/systemic therapy for oligometastatic TCC with lymph node, bone and lung lesions or local recurrence. Read More

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http://dx.doi.org/10.4149/neo_2018_180522N333DOI Listing
January 2019
5 Reads

Accelerated Hypofractionated Radiation Therapy for Elderly Frail Bladder Cancer Patients Unfit for Surgery or Chemotherapy.

Am J Clin Oncol 2019 Feb;42(2):179-183

Institute of Oncology.

Purpose/objectives: The main purpose of this study was to report treatment outcomes of definitive image-guided accelerated hypofractionated radiation therapy for elderly patients with muscle-invasive bladder cancer unsuitable for surgery or trimodality therapy.

Materials And Methods: Patients with confirmed muscle-invasive or high-risk T1 transitional cell carcinoma of the bladder, stage T1-T4aN0M0, who underwent transurethral resection of bladder tumor were irradiated with 45 Gy in 15 fractions. Comorbidity was assessed by Charlson Comorbidity Index. Read More

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http://dx.doi.org/10.1097/COC.0000000000000491DOI Listing
February 2019
16 Reads

A rare pure lymphoepithelioma-like carcinoma of the renal pelvis mimicking upper tract urothelial carcinoma: A potential diagnostic pitfall.

Kaohsiung J Med Sci 2018 11 14;34(11):657-658. Epub 2018 Apr 14.

Department of Pathology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S1607551X183004
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http://dx.doi.org/10.1016/j.kjms.2018.03.007DOI Listing
November 2018
9 Reads

Malignant Brenner tumor: Two case reports.

Case Rep Womens Health 2018 Oct 13;20:e00082. Epub 2018 Oct 13.

Dept. of Obstetrics & Gynecology, Geisinger Medical Center, Danville, PA, USA.

Malignant Brenner tumor (MBT) is a rare ovarian tumor that, given the infrequency of the disease, has not been well documented in the literature. Diagnosing MBT both radiographically and histologically remains a challenge. We report two cases of ovarian MBT, detailing the clinical presentation, radiographic characteristics, and histologic findings with supplementary imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22149112183011
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http://dx.doi.org/10.1016/j.crwh.2018.e00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197787PMC
October 2018
16 Reads

Performance Measurement and Quality Improvement Initiatives for Bladder Cancer Care.

Curr Urol Rep 2018 Oct 24;19(12):100. Epub 2018 Oct 24.

Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Purpose Of Review: Bladder cancer care is costly due to long surveillance periods for non-muscle-invasive bladder cancer (NMIBC) and comorbidities associated with the surgical treatment of muscle-invasive bladder cancer (MIBC). We reviewed current evidence-based practices and propose quality metrics for NMIBC and MIBC.

Recent Findings: For patients with NMIBC, we propose four categories of candidate quality metrics: (1) appropriate use of imaging, (2) re-staging transurethral resection of bladder tumor, (3) perioperative intravesical chemotherapy, and (4) induction and maintenance BCG in high-risk NMIBC. Read More

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http://link.springer.com/10.1007/s11934-018-0856-2
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http://dx.doi.org/10.1007/s11934-018-0856-2DOI Listing
October 2018
17 Reads

Performance of diffusion-weighted MRI post-CT urography for the diagnosis of upper tract urothelial carcinoma: Comparison with selective urine cytology sampling.

Clin Imaging 2018 Nov - Dec;52:208-215. Epub 2018 Aug 16.

Department of Diagnostic Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

Objectives: To evaluate the usefulness of adding diffusion-weighted MRI (DW-MRI) to CT urography (CTU) for diagnosing upper tract urothelial carcinoma (UTUC).

Materials And Methods: We retrospectively evaluated 102 high-risk patients with UTUC who underwent both CTU and DW-MRI. The diagnostic performance of CTU and DW-MRI was evaluated in all the patients. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.08.012DOI Listing
January 2019
5 Reads

Comparative sensitivity and specificity of imaging modalities in staging bladder cancer prior to radical cystectomy: a systematic review and meta-analysis.

World J Urol 2019 Apr 17;37(4):667-690. Epub 2018 Aug 17.

Department of Surgery, Austin Health, Heidelberg, VIC, Australia.

Purpose: The detection of lymph node metastases in bladder cancer has a significant impact on treatment decisions. Multiple imaging modalities are available to clinicians including magnetic resonance imaging, computed tomography and positron emission tomography. We aimed to investigate the utility of alternate imaging modalities on pre-cystectomy imaging in bladder cancer for the detection of lymph node metastases. Read More

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http://dx.doi.org/10.1007/s00345-018-2439-8DOI Listing
April 2019
12 Reads
2.670 Impact Factor

Are there any metastases to the chest in non-muscle-invasive bladder cancer patients on follow-up computed tomography?

Int Urol Nephrol 2018 Oct 16;50(10):1771-1778. Epub 2018 Aug 16.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Purpose: The purpose of the study was to retrospectively determine whether there are metastases to the chest in patients with primary non-muscle-invasive urothelial carcinoma in the bladder on the follow-up computed tomography (CT).

Methods: We analyzed 328 patients with follow-up chest CT for urothelial carcinoma of the bladder diagnosed between January 2004 and September 2013. We divided patients into four groups: Ta (n = 74), T1 (n = 78), carcinoma in situ (CIS, n = 25), and ≥ T2 (n = 151). Read More

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http://dx.doi.org/10.1007/s11255-018-1952-4DOI Listing
October 2018
6 Reads

Enhanced Endoscopy in Bladder Cancer.

Curr Urol Rep 2018 Aug 17;19(10):84. Epub 2018 Aug 17.

Institute of Urology, USC Keck/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Suite 7416, Los Angeles, CA, 90089, USA.

Purpose Of Review: Endoscopy coupled with targeted resections represents a cornerstone in the diagnosis, staging, and treatment of patients with bladder cancer. Direct visualization can be challenging and imprecise due to patient-, tumor-, and surgeon-specific factors. We will review contemporary endoscopic technologies and techniques used to improve our ability to safely identify and resect malignant lesions in patients with bladder cancer. Read More

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http://dx.doi.org/10.1007/s11934-018-0833-9DOI Listing
August 2018
1 Read

[Laparoscopic segmental ureteral resection with ileal-ureter substitution for ureteral urothelial carcinoma].

Urologiia 2018 Jul(3):129-133

Clinical Hospital at Nizhny Novgorod Railway Station of JSC RZD, Nizhny Novgorod, Russia.

Ureteral resection for the mid-ureter urothelial carcinoma is the operation of choice in patients with low-grade tumors. However, extensive excision within normal tissues may lead to difficulty in appropriate apposition of the ends of the ureter, while incomplete resection increases the risk of oncological progression. This article describes the first experience with laparoscopic segmental ureteral resection with the ileal - ureter substitution for mid-ureter urothelial carcinoma. Read More

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July 2018
1 Read

Upper and Lower Tract Urothelial Imaging Using Computed Tomography Urography.

Urol Clin North Am 2018 Aug;45(3):389-405

Department of Radiology, Johns Hopkins University, JHOC 3251, 601 North Caroline Street, Baltimore, MD 21287, USA.

Computed tomography (CT) urography is the best noninvasive method of evaluating the upper urinary tract for urothelial malignancies. However, the utility of CT urography is heavily contingent on the use of proper image acquisition protocols. This article focuses on the appropriate protocols for optimizing CT urography acquisitions, including contrast administration and the timing of imaging acquisitions, as well as the use of ancillary techniques to increase collecting system distention. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.03.004DOI Listing
August 2018
2 Reads

Canine urinary bladder transitional cell carcinoma tumor volume is dependent on imaging modality and measurement technique.

Vet Radiol Ultrasound 2018 Nov 10;59(6):767-776. Epub 2018 Jul 10.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine,  The Ohio State University, Columbus, OH, 43210.

Transitional cell carcinoma is the most common cancer of the canine urinary tract. The inconsistent appearance of transitional cell carcinoma in patients introduces error if applying mathematic models for extrapolating total tumor volume from linear measurements. Reliable techniques to assess tumor size are important for monitoring treatment response. Read More

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http://dx.doi.org/10.1111/vru.12652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218272PMC
November 2018
4 Reads

Modeling human bladder cancer.

World J Urol 2018 Nov 14;36(11):1759-1766. Epub 2018 Jun 14.

Department of Surgery, Faculty of Medicine, Université Laval, Quebec, QC, Canada.

Introduction: Bladder cancer is a major public health concern and the treatment options available are unable to significantly prevent disease recurrence and progression. The need for experimental tumor models to efficiently reproduce the pathology of human cancers has prompted researchers to attempt various approaches.

Methods: A PubMed search combining the MeSH bladder cancer and models was executed in March 2017. Read More

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http://dx.doi.org/10.1007/s00345-018-2369-5DOI Listing
November 2018

Under-stage and Overlook of Peritoneal Spread from Bladder Urothelial Carcinoma.

In Vivo 2018 Jul-Aug;32(4):905-910

Department of Medical Imaging and Intervention, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.

Background/aim: Bladder cancer can spread from the sub-peritoneal space superior and posterolateral to the peritoneal cavity via the peritoneal lining. The aim of this study was to improve the identification of peritoneal spread from bladder urothelial carcinoma based on computed tomography (CT) scans.

Materials And Methods: This is a retrospective study including patients selected with the following criteria: (i) pathology-confirmed urothelial carcinoma; (ii) peritoneal spread identified on CT scans from axial and corona views, either initially or after radical/partial cystectomy, concomitant chemoradiotherapy (CCRT), or radiotherapy. Read More

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http://dx.doi.org/10.21873/invivo.11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117758PMC
October 2018
25 Reads

Oncologic Outcomes of Patients Undergoing Diagnostic Ureteroscopy Before Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis.

J Laparoendosc Adv Surg Tech A 2018 Nov 6;28(11):1316-1325. Epub 2018 Jun 6.

1 State Key Laboratory of Oncology in South China, Department of Urology, Sun Yat-Sen University Cancer Center , Collaborative Innovation Center for Cancer Medicine, Guangzhou, China .

Background: Owing to the aggressive nature of radical nephroureterectomy (RNU), it is extremely important for the diagnostic modalities to be accurate. The European Association of Urology guidelines recommend that diagnostic ureteroscopy (URS) and biopsy be performed for upper urinary tract urothelial carcinomas (UUTCs). But that diagnostic URS adversely affects oncologic outcomes still exist. Read More

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http://dx.doi.org/10.1089/lap.2018.0015DOI Listing
November 2018
7 Reads

[CT texture analysis in bladder carcinoma: histologic grade characterization].

Zhonghua Zhong Liu Za Zhi 2018 May;40(5):379-383

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

To explore the value of CT texture analysis (CTTA) in differentiating the pathological grade of urothelial carcinoma of the bladder (UCB). A total of 53 lesions from 43 patients with bladder cancer confirmed by postoperative pathology were retrospectively analyzed, including 27 cases of high-grade urothelial carcinoma (HGUC) and 26 cases of low-grade urothelial carcinoma (LGUC). All the patients took pelvic CT and enhanced scanning in the same CT scanner with same scanning parameters. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.05.011DOI Listing
May 2018
1 Read

Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature.

J Ovarian Res 2018 May 30;11(1):44. Epub 2018 May 30.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Background: Although cases of cervical squamous cell carcinoma metastatic to the ovary have been previously documented, we report the first case of superficially invasive squamous cell carcinoma metastatic to the ovary.

Case Presentation: A 45-year-old woman with a two-year history of ovarian endometriosis confirmed by ultrasound underwent oophorectomy. On microscopic examination, a focus of malignant stratified epithelium, initially interpreted as transitional cell carcinoma, was identified within the endometriotic cyst wall. Read More

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http://dx.doi.org/10.1186/s13048-018-0417-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975711PMC
May 2018
1 Read

Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report.

BMC Nephrol 2018 05 30;19(1):123. Epub 2018 May 30.

Ultrasound Learning Center EFSUMB, Klinik Hirslanden, Zürich, Switzerland.

Background: Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and dysmorphic vessels, is defined as a potentially benign. The usual or classic angiomyolipoma is often found incidentally on imaging studies, relatively easily identified due to the presence of fat, in contrast to the epithelioid angiomyolipoma that can pose diagnostic challenges.

Case Presentation: We report a 51-year-old female patient in which an ultrasonography examination showed a solid mass close to the right renal pelvis with hypoechoic and hyperechoic areas. Read More

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http://dx.doi.org/10.1186/s12882-018-0919-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975514PMC
May 2018
10 Reads

[Recurrent Urothelial Carcinoma in the Uretero-Vesical Junction Treated with Partial Ureterectomy and Ureteroneocystostomy during Long-Term Follow-Up : A Case Report].

Hinyokika Kiyo 2018 Apr;64(4):157-160

The Department of Urology, Kitasato University School of Medicine.

A 54-year-old woman who had been treated with transurethral resection of bladder tumor for nonmuscle invasive urothelial carcinoma approximately nine years before presented with gross hematuria. Cystoscopy demonstrated a papillary tumor at the left side of the ureteral orifice. Magnetic resonance imaging showed a 1. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_4_157DOI Listing
April 2018
5 Reads

Urothelial carcinoma of an allograft ureter 10 years after deceased donor kidney transplantation.

BMJ Case Rep 2018 May 12;2018. Epub 2018 May 12.

Department of Urology, Beaumont Hospital, Dublin, Ireland.

The incidence of urothelial carcinoma (UC; formerly transitional cell carcinoma) is higher among renal transplant recipients compared with the general population. Upper urinary tract UC (UUT-UC) of allograft urothelium is a rare event with approximately 40 cases reported in the literature. Herein, we describe the clinical presentation and management of UUT-UC in a transplant ureter 10 years after deceased donor kidney transplantation. Read More

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http://dx.doi.org/10.1136/bcr-2017-223087DOI Listing
May 2018
6 Reads

Near infrared photoimmunotherapy targeting bladder cancer with a canine anti-epidermal growth factor receptor (EGFR) antibody.

Oncotarget 2018 Apr 10;9(27):19026-19038. Epub 2018 Apr 10.

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Anti-epidermal growth factor receptor (EGFR) antibody therapy is used in EGFR expressing cancers including lung, colon, head and neck, and bladder cancers, however results have been modest. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate which is activated by NIR light. NIR-PIT is in clinical trials in patients with recurrent head and neck cancers using cetuximab-IR700 as the conjugate. Read More

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http://dx.doi.org/10.18632/oncotarget.24876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922375PMC
April 2018
9 Reads
6.360 Impact Factor

Renal Pelvis Carcinoma with Renal Vein or Inferior Vena Cava Involvement Linked to Early-onset Lung Metastasis Based on CT Scan Diagnosis.

Anticancer Res 2018 05;38(5):3187-3192

Department of Medical Imaging and Intervention, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.

Background/aim: Renal pelvis cancer with invasion of the renal vein or inferior vena cava (IVC) carries a poor prognosis. The present study investigated whether early-onset lung metastasis in these patients contributes to their poor outcome.

Patients And Methods: Data were retrospectively collected from hospitalized patients with metastatic renal pelvis urothelial cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12583DOI Listing
May 2018
5 Reads

Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

Dis Markers 2018 30;2018:5823870. Epub 2018 Jan 30.

Department of Urology, Eberhard Karls University, Tuebingen, Germany.

Objectives: To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC).

Patients And Methods: The study comprised 758 urine samples either collected from the bladder ( = 373) or UUT ( = 385). All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy. Read More

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http://dx.doi.org/10.1155/2018/5823870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831978PMC
September 2018
49 Reads

Current Staging Strategies for Muscle-Invasive Bladder Cancer and Upper Tract Urothelial Cell Carcinoma.

Urol Clin North Am 2018 May;45(2):143-154

Division of Urology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis Street, Boston, MA 02111, USA.

Please note, the synopsis was used from your supplied original manuscript, and not the accompanying abstract, per journal style: This article discusses current staging strategies in muscle-invasive bladder cancer and upper tract urothelial cell carcinoma. Current staging methods can help identify patients with localized or metastatic disease but are subject to limitations which must be considered. Read More

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http://dx.doi.org/10.1016/j.ucl.2017.12.001DOI Listing
May 2018
5 Reads

Intracavitary therapies for upper tract urothelial carcinoma.

Expert Rev Clin Pharmacol 2018 May 20;11(5):487-493. Epub 2018 Apr 20.

a Department of Surgery, Division of Urology , Penn State Hershey Surgical Specialties , Hershey , PA , USA.

Introduction: While radical nephroureterectomy remains the gold-standard for upper tract urothelial carcinoma (UTUC), there is a growing push for organ-sparing therapy in low-risk disease. Herein we review the use of intracavitary topical therapy for treatment of UTUC. Areas covered: A PubMed search was performed for studies pertaining to upper tract urothelial carcinoma, with 236 articles reviewed, and distilled for content pertinent to intracavitary therapy for UTUC. Read More

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https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1
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http://dx.doi.org/10.1080/17512433.2018.1461560DOI Listing
May 2018
10 Reads

PD-1 and PD-L1 inhibitors after platinum-based chemotherapy or in first-line therapy in cisplatin-ineligible patients: Dramatic improvement of prognosis and overall survival after decades of hopelessness in patients with metastatic urothelial cancer.

Memo 2018 8;11(1):43-46. Epub 2018 Mar 8.

1Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Until recently, there were no true innovations in the management of locally advanced (aUC) and metastatic urothelial cancer (mUC) in the last three decades. Vinflunine has been approved by the EMA (European Medicines Agency) with only limited improvement compared to best supportive care in second line treatment. In addition, gemcitabine/cisplatin has been established as an alternative to methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC). Read More

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http://link.springer.com/10.1007/s12254-018-0396-y
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http://dx.doi.org/10.1007/s12254-018-0396-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862914PMC
March 2018
8 Reads

A case of pseudorenal failure - spontaneous rupture of the urinary bladder.

Acta Gastroenterol Belg 2017 Jul-Sep;80(3):419-421

Department of internal medicine, AZ Groeninge, Kortrijk.

A 64-year old woman was admitted to the hospital for severe abdominal pain and distension after gardening and chopping wood the day before. She had a medical history of superficial transitional cell carcinoma (TCC) of the urinary bladder and a laparoscopic nefro-ureterectomy for an invasive TCC of the upper urothelial tract in 2012. Clinical examination showed an acute abdomen. Read More

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April 2018
43 Reads

[Application of narrow-band imaging flexible ureteroscopy in the diagnosis, treatment and follow-up of upper tract urothelial carcinomas].

Zhonghua Wai Ke Za Zhi 2018 Mar;56(3):222-226

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

To investigate application value of narrow-band imaging (NBI) flexible ureteroscopy in the diagnosis, treatment and follow-up of upper urinary tract transitional carcinomas (UTUC). From June 2015 to June 2017, 16 patients of UTUC were treated by flexible ureteroscopy with white light (WLI) and NBI at Department of Urology, Peking University Third Hospital , including 10 females and 6 males. The age of patients ranged from 43 to 84 years (average 68. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2018.03.011DOI Listing
March 2018
64 Reads

Quantitative evaluation of canine urinary bladder transitional cell carcinoma using contrast-enhanced ultrasonography.

BMC Vet Res 2018 Mar 12;14(1):84. Epub 2018 Mar 12.

Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, 98168, Messina, Italy.

Background: In veterinary medicine, contrast-enhanced ultrasonography allowed the accurate quantification of liver, splenic and kidney vascularization in healthy dogs and the differentiation between malignant and benign hepatic, renal, and splenic nodules in dogs and cats based on perfusion patterns. The utility of contrast-enhanced ultrasonography in other applications is still under study. The aim of this study was to develop diagnostic criteria by contrast-enhanced ultrasonography in 8 client-owned adult dogs affected by urinary bladder transitional cell carcinoma with definitive diagnosis made by cytopathologic evaluation after suction biopsy. Read More

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http://dx.doi.org/10.1186/s12917-018-1384-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848439PMC
March 2018
8 Reads

Renocolic fistula secondary to urothelial carcinoma.

BMJ Case Rep 2018 Mar 9;2018. Epub 2018 Mar 9.

Urology, Queensland Health, Ipswich, Queensland, Australia.

A 77-year-old man presented with watery, bloody diarrhoea, symptomatic anaemia and signs of sepsis. He was well known to our unit with a history of extensive low-grade urothelial carcinoma involving a solitary kidney. CT performed on admission demonstrated a new finding of renocolic fistula. Read More

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http://dx.doi.org/10.1136/bcr-2017-223558DOI Listing
March 2018
2 Reads

T4 urothelial carcinoma in undiagnosed closed bladder exstrophy in a post-menopausal female.

Can J Urol 2018 02;25(1):9214-9216

Division of Urology, Department of Surgery, Cook County Health and Hospitals System, Chicago, Illinois, USA.

It is rare to see an adult presenting with exstrophy of the bladder. Malignant conversion in exstrophy occurs in 4%, with adenocarcinoma as the most common histopathology. We report the first case of metastatic high grade urothelial carcinoma with squamous and sarcomatoid differentiation arising from undiagnosed, closed bladder exstrophy in a female at advanced age with associated bilateral deep vein thrombosis and clot retention. Read More

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February 2018
5 Reads

Epidermal growth factor receptor function in the human urothelium.

Int Urol Nephrol 2018 Apr 5;50(4):647-656. Epub 2018 Mar 5.

Department of Pharmacology, The Sahlgrenska Academy, University of Gothenburg, Box 431, 405 30, Göteborg, Sweden.

Purpose: Epidermal growth factor receptor (EGFr)-targeted therapy may be used in subgroups of patients with urinary bladder cancer. Here we assessed the role of EGFr in urothelial proliferation and migration in a two- and three-dimensional cell culture system.

Methods: UROtsa cells derived from normal urothelium and malignant T24 cells were cultured in a Type I collagen gel. Read More

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http://dx.doi.org/10.1007/s11255-018-1831-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878195PMC
April 2018
4 Reads

Multiparametric ultrasound findings of tuberculous orchitis following bacillus Calmette-Guérin therapy.

Radiol Case Rep 2017 Dec 12;12(4):746-751. Epub 2017 Sep 12.

Department of Histopathology, Southend University Hospital, Essex, UK.

Granulomatous bacillus Calmette-Guérin (BCG) infection, both localized and disseminated, as a complication of intravesical therapy for transitional cell carcinoma of the bladder is a recognized but highly unusual phenomenon. We report the case of an 89-year-old gentleman with a history of bladder transitional cell carcinoma and subsequent intravesical BCG instillation of the bladder who presented to his general practitioner with a non-tender lump in his left testis. Histopathologic and microbiological evaluation of the subsequent orchidectomy specimen revealed granuloma formation secondary to BCG infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433173020
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http://dx.doi.org/10.1016/j.radcr.2017.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823296PMC
December 2017
2 Reads

Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report.

Am J Case Rep 2018 Feb 13;19:158-162. Epub 2018 Feb 13.

Department of Internal Medicine, Florida Hospital Orlando, Orlando, FL, USA.

BACKGROUND Plasmacytoid is a rare histological variant of urothelial carcinoma (UC). Since the first reported case of plasmacytoid urothelial carcinoma (PUC), in 1991, only about 100 cases have since been reported, with most cases involving the bladder. Urothelial carcinomas of the upper urinary tract represent only 5% of urothelial cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819306PMC
February 2018
6 Reads

[Clinicopathologic features with collecting duct carcinoma of kidney: report of 10 cases].

Zhonghua Bing Li Xue Za Zhi 2018 Feb;47(2):123-127

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To study the pathological features, immunophenotypes, differential diagnoses and prognostic parameters of collecting duct carcinoma of the kidney (CDC). Clinical imaging, histopathology, immunohistochemistry, and survival data of 10 patients at First Affiliated Hospital of Nanjing Medical University from January 2009 to August 2017 were retrospectively analyzed along with a review of literatures. The clinical symptoms of CDC were not specific, and image examinations showed space-occupying mass lesions. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.02.009DOI Listing
February 2018
7 Reads

Evaluation of two-dimensional ultrasonography and computed tomography in the mapping and measuring of canine urinary bladder tumors.

Vet J 2018 02 12;232:23-26. Epub 2017 Dec 12.

Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA. Electronic address:

Determining the dimensions of transitional cell carcinomas (TCCs) of the urinary bladder in dogs is important in assessing tumor progression and the response to treatment. The primary aim of this study was to evaluate the reliability of a standardized two-dimensional (2-D) ultrasound (US) protocol performed by a single experienced operator. Secondary aims were to compare World Health Organization (WHO) and Response Evaluation Criteria in Solid Tumors (RECIST) guidelines, and to compare measurements by two operators following these guidelines. Read More

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http://dx.doi.org/10.1016/j.tvjl.2017.12.008DOI Listing
February 2018
1 Read

Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist.

Med Clin North Am 2018 Mar;102(2):231-249

Center for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Q10-1, Cleveland, OH 44195, USA. Electronic address:

Malignancies of the urinary tract (kidney, ureter, and bladder) are distinct clinical entities. Hematuria is a unifying common presenting symptom for these malignancies. Surgical management of localized disease continues to be the mainstay of treatment, and early detection is important in the prognosis of disease. Read More

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http://dx.doi.org/10.1016/j.mcna.2017.10.002DOI Listing
March 2018
4 Reads

Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs.

Vet Surg 2018 Apr 5;47(3):367-377. Epub 2018 Feb 5.

University of Turin, Grugliasco, Italy.

Objective: To describe the complications and outcome after total prostatectomy in dogs with histologically confirmed prostatic carcinoma.

Study Design: Multi-institutional retrospective case series.

Animals: 25 client-owned dogs. Read More

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http://dx.doi.org/10.1111/vsu.12768DOI Listing
April 2018
30 Reads

Acute Kidney Injury in Cancer Patients.

Contrib Nephrol 2018 23;193:137-148. Epub 2018 Jan 23.

Background: Renal complications are a relevant clinical issue in patients with cancer; conversely, cancer in patients affected by kidney diseases is a growing problem mainly due to the aging of the general population. Onco-Nephrology is a novel subspecialty addressing these issues.

Summary: Acute kidney injury (AKI) is an important cause of morbidity and mortality in cancer patients, and recognizes a number of different causes, which can impact, directly and indirectly, on kidney function. Read More

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http://dx.doi.org/10.1159/000484970DOI Listing
April 2019
2 Reads

Asymptomatic solitary bladder plasmocytoma: A case report and literature review.

Medicine (Baltimore) 2017 Dec;96(50):e9347

Department of Urology and Renal Transplantation.

Rationale: Solitary extramedullary plasmocytoma may arise in any organ, either as a primary tumor or as part of a systemic myeloma; if it rarely affects bladder, it presents with urinary symptoms. We describe the first case of asymptomatic BP occasionally diagnosed in a patient with ascites.

Patient Concerns: A 74-year-old woman with hepatitis C virus (HCV)-related liver cirrhosis presented with ascites and no urinary or other symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000009347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815820PMC
December 2017
8 Reads

Bladder cancer presenting with acrometastases: a different cause of foot pain.

Skeletal Radiol 2018 Jul 1;47(7):1003-1009. Epub 2018 Feb 1.

Department of Radiology, Ospedale Villa Scassi - Sampierdarena, Corso Scassi 1, 16121, Genoa, Italy.

Acrometastasis means tumor seeding distally to the elbow or the knee and is an uncommon event. Foot acrometastases occur in 0.58% of patients with skeletal metastases overall, and only about 10% of these are caused by bladder cancer. Read More

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http://link.springer.com/10.1007/s00256-018-2888-6
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http://dx.doi.org/10.1007/s00256-018-2888-6DOI Listing
July 2018
5 Reads

Peptide-Mediated Targeting Mesoporous Silica Nanoparticles: A Novel Tool for Fighting Bladder Cancer.

J Biomed Nanotechnol 2017 Feb;13(2):232-42

Transitional cell carcinoma of the bladder is particularly devastating due to its high rate of recurrence and difficulty in retention of treatments within the bladder. Current cystoscopic approaches to detect and stage the tumor are limited by the penetrative depth of the cystoscope light source, and intravesical dyes that highlight tumors for surgical resection are non-specific. To address the needs for improved specificity in tumor detection and follow-up, we report on a novel technology relying on the engineered core of mesoporous silica (MSN) with surface modifications that generate contrast in fluorescence and magnetic resonance imaging (MRI). Read More

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February 2017
2 Reads

Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period.

Prague Med Rep 2017;118(4):119-127

Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Renal cell carcinomas (RCCs) account 80-85% of all primary renal neoplasms and originate from the renal cortex. The patients who underwent radical or partial nephrectomy for renal tumour in our unit between January 2005 and 2015 were evaluated retrospectively. The patients were divided into two groups; group 1 includes patients who were treated between January 2005 and December 2009, group 2 those from January 2010 to 2015. Read More

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http://dx.doi.org/10.14712/23362936.2017.13DOI Listing
April 2018
8 Reads