Search Our Scientific Publications & Authors

Acta Neurol Scand 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Objectives: The aim of this study was to investigate differences in cerebral blood flow (CBF) and functional networks between transient global amnesia (TGA) patients with a single event and those with recurrent events using arterial spin labeling (ASL) MRI.

Methods: We enrolled patients with TGA and classified them into two groups according to the number of TGA events: TGA patients with a single event and those with recurrent events. MRI scans were performed within 24 h after TGA ictal onset in all patients. Read More

J Clin Neurosci 2021 Jul 29;89:15-19. Epub 2021 Apr 29.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. Electronic address:

Neuron-specific enolase (NSE) is a glycolytic enzyme, which is associated with neuronal cell dysfunction in the brain. This study evaluated the role of serum NSE levels of patients with transient global amnesia (TGA). In addition, the relationship between serum NSE levels and the clinical features of TGA was explored. Read More

J Neurol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68135, Mannheim, Germany.

Introduction: The etiology of transient global amnesia (TGA) is still a matter of debate. Based, among others, on the observation of a close temporal relation between certain events and subsequent TGA episodes, recent proposals discuss the relevance of stress-associated processes impacting on hippocampal functioning. Circadian, infra- and ultradian rhythmicity has been found to play a relevant role in the multifactorial pathomechanisms of various disorders but has not been thoroughly studied in TGA. Read More

Neuropsychiatr Dis Treat 2021 25;17:1611-1619. Epub 2021 May 25.

Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen, People's Republic of China.

Background And Aim: Transient global amnesia (TGA) was first described by Bender in 1956 and is characterized by sudden, temporary, and anterograde memory loss. This study aimed to explore the possible mechanisms of and lesions responsible for TGA.

Methods: Retrospective data were collected from all patients with TGA admitted to Zhongshan Hospital, affiliated with Xiamen University, between October 1, 2011, and October 30, 2018. Read More

Can J Neurol Sci 2021 May 24:1-7. Epub 2021 May 24.

J Neuropsychol 2021 May 21. Epub 2021 May 21.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), Heidelberg University, Mannheim, Germany.

As a clinical model of hippocampal dysfunction, transient global amnesia (TGA) causes reversible memory disturbance. While episodic memory deficits in TGA patients have been extensively described, data regarding semantic memory involvement are sparse and contradictory. We report impaired semantic fluency performance in 16 patients with hippocampal lesions on MRI during acute TGA compared to their performance one day later and to that of 20 healthy subjects. Read More

Prim Care Companion CNS Disord 2021 Apr 22;23(2). Epub 2021 Apr 22.

Department of Psychiatry, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

J Gen Fam Med 2021 May 30;22(3):154-155. Epub 2020 Dec 30.

Department of General Internal Medicine Toyota Regional Medical Center Toyota Japan.

This manuscript presents a case report of transient global amnesia with bilateral hippocampal lesions which might be triggered by the fear of getting infected by coronavirus disease 2019 (COVID-19). The purpose of this article is to facilitate the clinicians in understanding that an increasing number of patients with transient global amnesia have been reported during the COVID-19 global outbreak. Read More

Cardiovasc Diagn Ther 2021 Apr;11(2):472-477

Department of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China.

Transient global amnesia (TGA) is a neurological disorder characterized by sudden onset of anterograde amnesia with or without retrograde amnesia, lasting less than 24 hours, without other clinical neurological dysfunction. TGA with short duration and benign prognosis is usually neglected in clinical practice. Transient total amnesia after radiofrequency ablation is rare and its etiology is unknown. Read More

J Neurol Sci 2021 06 17;425:117464. Epub 2021 Apr 17.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), Heidelberg University, Mannheim, Germany.

Introduction: Physically or emotionally charged events have consistently been reported as precipitating an episode of transient global amnesia (TGA). In conjunction with evidence of hippocampal involvement from neuroimaging, this has promoted the hypothesis that TGA is a stress-related disorder.

Methods: In this retrospective observational study, medical records of 389 patients with TGA were analysed regarding documented precipitating events, which were classified according to previously suggested criteria. Read More

Brain Commun 2021 13;3(2):fcab038. Epub 2021 Mar 13.

Cognitive & Behavioural Neurology, University of Exeter Medical School, College House, St Luke's Campus, Exeter EX1 2LU, UK.

The term transient epileptic amnesia was coined in 1990 to describe a form of epilepsy causing predominantly amnestic seizures which could be confused with episodes of Transient Global Amnesia. Subsequent descriptions have highlighted its association with 'atypical' forms of memory disturbance including accelerated long-term forgetting, disproportionate autobiographical amnesia and topographical amnesia. However, this highly treatment-responsive condition remains under-recognized and undertreated. Read More

Neurohospitalist 2021 Jan 10;11(1):84-86. Epub 2020 Sep 10.

Regions Hospital Comprehensive Stroke Center, St Paul, MN, USA.

Evidence of involvement of the nervous system in COVID-19 disease is accumulating. We describe a case of a 53-year-old man presented with classic syndrome of transient global amnesia with symptoms lasting less than 24 hours and mild transient unexplained fever. Workup including brain MRI, electroencephalogram, and chest X ray was negative and the patient was discharged. Read More

Neurocase 2021 Apr 15;27(2):196-204. Epub 2021 Apr 15.

Normandie Univ, UNICAEN, PSL Université Paris, EPHE, INSERM, U1077, CHU de Caen, Centre Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.

Numerous evidences suggest the existence of relationships between the impairment of episodic memory, acute stress exposure and variations in self-awareness (SA). Here, we examined 27 patients presenting transient global amnesia (TGA), a clinical condition which combines episodic amnesia and high anxiety, thanks to state and trait questionnaires of SA. We observed variation of SA depending on the stage of TGA (acute, recovery and follow-up). Read More

Clin Imaging 2021 Mar 29;78:154-159. Epub 2021 Mar 29.

Department of Radiology, Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Purpose: Transient global amnesia (TGA) is one of the most enigmatic syndromes in clinical neurology. The detection rate of TGA lesions in 2D/3D FLAIR sequences has not been evaluated.

Methods: A total of 201 patients (44 men and 157 women; mean age, 60. Read More

J Stroke Cerebrovasc Dis 2021 May 5;30(5):105738. Epub 2021 Mar 5.

Metro Health System, Cleveland, United States.

Cortex 2021 May 10;138:38-39. Epub 2021 Feb 10.

Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom. Electronic address:

Some recent authors have claimed that Théodule-Armand Ribot described transient global amnesia in the nineteenth century in his monograph, Diseases of memory, An examination of this work was undertaken to determine whether or not this claim is true. Whilst Ribot cites Koempfen's thorough report of a case of transient amnesia, dating from 1835, this does not conform to current understanding of transient global amnesia. Read More

Rev Neurosci 2021 Mar 5. Epub 2021 Mar 5.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Mezourlo Hill, 41100Larissa, Greece.

The examination of the risk factors that affect the recurrence of transient global amnesia (TGA) may shed light on the pathophysiological substrate of the disease. A systematic review was performed to identify the factors associated with the recurrence of TGA. MEDLINE, EMBASE, CENTRAL and PsycINFO were meticulously searched. Read More

J Neurol 2021 Mar 2. Epub 2021 Mar 2.

Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

Introduction: Data regarding the risk of cerebrovascular events following transient global amnesia (TGA) remain controversial. While some neuroradiological studies suggest an underlying cerebrovascular etiology, results from the clinical studies have been largely conflicting. We, therefore, aimed to evaluate the risk of ischemic stroke in a large, nationally representative sample of patients with TGA. Read More

Am J Med 2021 Feb 21. Epub 2021 Feb 21.

Division of General Internal Medicine, Department of Medicine, McMaster University, Ontario, Canada.

Neuroimage Clin 2021 12;30:102586. Epub 2021 Feb 12.

Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany. Electronic address:

Objective: In this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA).

Methods: 20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i. Read More

Clin Neurol Neurosurg 2021 Mar 27;202:106522. Epub 2021 Jan 27.

Department of Radiology, Changi General Hospital, Singapore.

Objective: To determine prevalence and characteristics of mesiotemporal diffusion weighted imaging (DWI) lesions in transient global amnesia (TGA), and to determine prevalence of "missed" DWI lesions on routine radiological reporting.

Methods: This is a retrospective study of patients with TGA admitted to a tertiary care hospital over ten years. Patients with TGA, who underwent magnetic resonance imaging (MRI) of the brain within one week of index event, were included in this study. Read More

Rev Neurosci 2021 Jan 29. Epub 2021 Jan 29.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Mezourlo Hill, 41100 Larissa, Greece.

Transient Global Amnesia (TGA) constitutes an enigmatic amnestic condition. In view of the admittedly limited knowledge regarding the nature of TGA, we decided to systematically review existing evidence for the generally regarded benign course of the disease. MEDLINE, EMBASE, CENTRAL and PsycINFO were searched for relevant articles. Read More

Front Neuroendocrinol 2021 Apr 2;61:100909. Epub 2021 Feb 2.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Transient Global Amnesia (TGA) is an enigmatic amnestic syndrome. We conducted a systematic review to investigate the relationship between the conventional cardiovascular risk factors and TGA. MEDLINE, CENTRAL, EMBASE and PsycINFO were comprehensively searched and 23 controlled observational studies were retrieved. Read More

Rinsho Shinkeigaku 2021 Feb 26;61(2):136-139. Epub 2021 Jan 26.

Department of Neurology, Kameda Medical Center.

A 66-year-old woman with a history of hypertension complained about sudden short-term memory loss. On arrival to our outpatient clinic, she was alert and oriented and did not have chest pain or shortness of breath. Neurological and neuropsychological examinations were within normal limits. Read More

Neuroradiology 2021 Jan 23. Epub 2021 Jan 23.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-ro 875, Haeundae-gu, Busan, Republic of Korea.

Purpose: This study aimed to evaluate alterations in structural covariance network and effective connectivity of the intrahippocampal circuit in patients with transient global amnesia (TGA). We also investigated whether there were differences of them according to recurrence.

Methods: We enrolled 88 patients with TGA and 50 healthy controls. Read More

J Infect Chemother 2021 Jun 20;27(6):902-905. Epub 2021 Jan 20.

General Medicine, Fukuoka University Hospital, Fukuoka, Japan.

Transient global amnesia (TGA) is an uncommon disease characterized by sudden onset anterograde amnesia that typically improves within 24 hours. A 35-year-old woman presented with complete disruption of memory that had started on the previous day. She had fever and heart murmur and was diagnosed as having infective endocarditis with Staphylococcus lugdunensis, a coagulase-negative staphylococcus. Read More

Neurol Sci 2021 Jun 18;42(6):2515-2517. Epub 2021 Jan 18.

Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal.

Transient global amnesia (TGA) is a neurological syndrome with rather distinctive brain MRI features, namely hyperintense lesion in hippocampus on diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) sequences. Post-traumatic amnesia is another amnestic syndrome which can also show hyperintense lesions in brain MRI due to cytotoxic oedema caused by traumatic brain injury. We present a case of a patient with post-traumatic amnesia with a brain MRI image mimic of TGA. Read More

Neuroscientist 2021 02;27(1)

Can J Neurol Sci 2021 Jan 12:1-2. Epub 2021 Jan 12.

Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Cerebrovasc Dis 2021 7;50(2):171-177. Epub 2021 Jan 7.

Department of Neurology/Stroke Unit, Katholisches Klinikum Koblenz-Montabaur, Koblenz, Germany.

Background: Transient global amnesia (TGA) is a syndrome featuring acute anterograde amnesia as the most striking clinical symptom. Its etiology is still a matter of debate. Most neurological guidelines allow the diagnosis on the basis of clinical criteria only; a more extensive evaluation is recommended only for patients with "red flags" like severe headache, nausea or vomiting, or metabolic abnormalities. Read More