212 results match your criteria Transient Acantholytic Dermatosis
Skinmed 2017 1;15(6):483-484. Epub 2017 Dec 1.
Section of Dermatology, Department of Medicine, University of Chicago, Pritzker School of Medicine; Chicago, IL;
A 79-year-old man with a recent diagnosis of acute myeloblastic leukemia received induction chemotherapy with daunorubicin and cytarabine, plus moxifloxacin and fluconazole prophylaxis. Approximately 2 weeks later, an asymptomatic eruption appeared on his trunk. He then developed a neutropenic fever and was started on aztreonam, vancomycin, voriconazole, and amikacin and was transferred to our facility from an outside hospital. Read More
Eur J Dermatol 2017 12;27(6):648-650
Department of Dermatology, Venerology, and Allergology; University Medical Center, Ruprecht-Karl University, Heidelberg, Germany.
Dermatol Pract Concept 2017 Jul 31;7(3):51-54. Epub 2017 Jul 31.
Dermatology Clinic, University of Catania, Italy.
Grover's disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 54-year-old female affected by Grover's disease and showing a Darier-like histopathological pattern is described. Polarized light dermoscopy (PLD) revealed the presence of polygonal, star-like shaped yellowish/brownish areas of various sizes surrounded by a thin whitish halo. Read More
J Am Acad Dermatol 2017 Nov 14;77(5):952-957.e1. Epub 2017 Sep 14.
Department of Pathology, University of California, San Francisco, California. Electronic address:
Background: Grover disease is an acantholytic disorder that typically occurs on the trunk of older individuals, primarily white men, in association with heat and xerosis. Cases with extensive and/or atypical distributions have been reported.
Objective: To review the literature characterizing the population, morphology, associations, and disease course of extensive or atypical eruptions of Grover disease. Read More
Int J Dermatol 2017 Oct 2;56(10):1052-1054. Epub 2017 Aug 2.
Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan.
Int J Dermatol 2017 May 10;56(5):527-533. Epub 2017 Feb 10.
Oncodermatology department, CIC, CHU, Nantes, France.
Background: Immune checkpoint blockade therapy (ICBT) for the treatment of melanoma has led to an important improvement of overall survival in advanced stage patients. However, secondary cutaneous maculopapular eruptions (CMPEs) are frequent and remain poorly characterized.
Methods: We performed a retrospective analysis of melanoma patients from our institution who developed CMPEs during ICBT. Read More
J Cutan Pathol 2017 May 16;44(5):486-489. Epub 2017 Feb 16.
Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
A total of 3 cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All 3 patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all 3 patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in 1 patient, the clinical impression included herpesvirus infection. Read More
J Am Acad Dermatol 2017 Feb;76(2S1):S60-S63
Dermatology Unit, Second University of Naples, Naples, Italy.
Acta Derm Venereol 2017 05;97(5):667-668
Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
J Immunother Cancer 2016 20;4:55. Epub 2016 Sep 20.
Department of Melanoma Medical Oncology, University of Texas-MD Anderson Cancer Center, Houston, TX USA.
Background: Immune related adverse events (irAEs) are common side effects of checkpoint inhibitory (CPI) therapies targeting CTLA-4 and PD-1/PD-L1. Grover's disease is an uncommon dermatologic condition with unclear pathogenesis previously reported as an irAE with ipilimumab.
Case Presentation: We report an additional case of ipilimumab-induced Grover's disease. Read More
Curr Probl Dermatol 2016 23;50:149-54. Epub 2016 Aug 23.
Paraneoplastic itch occurs as the result of a systemic reaction to an underlying malignancy. Paraneoplastic itch is most commonly associated with lymphoproliferative malignancies and solid tumors that result in cholestasis. Paraneoplastic itch may occur in the absence of a primary rash or in association with dermatologic conditions such as erythroderma, acanthosis nigricans, dermatomyositis, Grover's disease, and eruptive seborrheic keratosis. Read More
J Immunother Cancer 2016 16;4:47. Epub 2016 Aug 16.
Cantonal Hospital Baselland, Institute of Pathology, Mühlemattstrasse 11, CH-4410 Liestal, Switzerland.
Background: Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (PD-L1). Skin toxicity most commonly includes a maculopapular erythematous rash and pruritus. Rarely life threatening complications such as Steven's Johnson syndrome or toxic epidermal necrolysis may occur. Read More
Australas J Dermatol 2016 Nov 30;57(4):e120-e122. Epub 2016 Jun 30.
Westmead Hospital, Sydney, New South Wales, Australia.
Cutaneous eruptions in recipients of allogeneic haematopoietic stem cell transplantation (AHSCT) are frequent, and common aetiologies include graft-versus-host disease (GVHD), drug reactions, viral infections and engraftment syndrome. Transient acantholytic dermatosis or Grover's disease has been described in oncology patients and it is rarely reported after AHSCT. However, this benign and self-limiting condition should be histologically distinguished from other, more serious entities, mainly stage IV GVHD, in order to avoid inappropriate treatment with corticosteroids and intensive immunosuppression. Read More
Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.
Temple University School of Medicine, Philadelphia, PA, USA.
Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.
Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.
Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More
J Dermatol 2016 Aug 19;43(8):937-9. Epub 2016 Feb 19.
Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
Distinguishing Grover's disease from other papular dermatoses is often a troublesome task. According to two relatively recent case reports, dermoscopy may be useful in assisting the diagnosis of such a disorder by showing a peculiar pattern. The aim of this study was to evaluate the dermoscopic features of Grover's disease in a larger series of patients and correlate dermoscopy with histopathological findings. Read More
Australas J Dermatol 2017 Feb 14;58(1):50-52. Epub 2016 Jan 14.
Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Nefrologia 2015 17;35(3):331-4. Epub 2015 Jun 17.
Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Ferrol, Ferrol, A Coruña, España.
G Ital Dermatol Venereol 2015 Dec 10;150(6):756-8. Epub 2015 Jul 10.
Dermatology Unit, Department of Clinical Medicine and Immunologic Science, University of Siena, "Le Scotte" Hospital, Siena, Italy -
Acta Derm Venereol 2015 Jul;95(6):762-3
Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo 060-8638, Japan.
Indian J Dermatol 2014 Nov;59(6):621-3
Department of Dermatology, Apollo Gleneagles Hospital, Kolkata, West Bengal, India. E-mail:
Ann Dermatol Venereol 2014 Nov 23;141(11):689-93. Epub 2014 Oct 23.
Clinique de dermatologie et photobiologie, hôpital Nord, CHU de Grenoble, Cs 10217, boulevard de la-Chantourne-La-Tronche, 38043 Grenoble cedex 9, France.
Background: Acantholytic dyskeratosis under BRAF inhibitors are dermatological diseases rarely reported to date.
Patients And Methods: We report 2 cases of acantholytic dyskeratosis, reaching the trunk and the seborrheic zones, not itchy, appeared one month after the introduction of vemurafenib. The histological analysis was typical of a "Grover-like rash" for the 2 patients. Read More
Dermatol Pract Concept 2014 Oct 31;4(4):21-7. Epub 2014 Oct 31.
Division of Dermatology, University of California San Diego, San Diego, California.
Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections.
Purpose: To review the histologic differential diagnosis of conditions with epithelial and histiocytic multinucleated giant cells-since multinucleated giant cells in the epidermis are not always pathognomonic of a cutaneous herpes virus infection-and to summarize dermatoses in which herpes virus infection has been observed to coexist. Read More
J Cutan Pathol 2015 Feb 24;42(2):136-43. Epub 2014 Nov 24.
Department of Anatomical Pathology, Liverpool Hospital, Liverpool, Australia.
Crystal storing histiocytosis (CSH) is a rare condition where crystals accumulate in the cytoplasm of macrophages and is usually associated with a lymphoplasmacytic neoplasm producing a monoclonal immunoglobulin with kappa light chain. CSH with primary manifestation in the skin is extraordinarily rare and limited to four case reports in the literature. Here we present two cases of cutaneous CSH. Read More
MMW Fortschr Med 2014 Apr;156(6):5, 43
Br J Dermatol 2014 Nov 24;171(5):1236-7. Epub 2014 Sep 24.
Department of Dermatology, University Hospital of Montpellier, University Montpellier 1, 80 rue Augustin Fliche, F-34295, Montpellier Cedex 5, France.
Ann Dermatol 2014 Feb 17;26(1):117-8. Epub 2014 Feb 17.
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
G Ital Dermatol Venereol 2013 Dec;148(6):609-19
Division of Dermatology Department of Surgery and Translational Medicine University of Florence, Florence, Italy -
Although Malassezia yeasts are a part of the normal microflora, under certain conditions they can cause superficial skin infection, such as pityriasis versicolor (PV) and Malassezia folliculitis. Moreover the yeasts of the genus Malassezia have been associated with seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and, less commonly, with confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis. The study of the clinical role of Malassezia species has been surrounded by controversy due to the relative difficulty in isolation, cultivation, and identification. Read More
J Dermatol 2014 Jan 20;41(1):104-5. Epub 2013 Dec 20.
Department of Dermatology, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
JAMA 2013 Dec;310(22):2443-50
Department of Dermatology, University of California, San Francisco.
Importance: Pruritus is a common problem among elderly people and, when severe, causes as much discomfort as chronic pain. Little evidence supports pruritus treatment, limiting therapeutic possibilities and resulting in challenging management problems.
Objectives: To present the evidence on the etiology, diagnosis, and treatment of pruritus in the elderly and, using the best available evidence, provide an approach for generalist physicians caring for older patients with pruritus. Read More
Clin Nucl Med 2014 Feb;39(2):e173-5
From the Departments of *Radiology, and †Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.
A 48-year-old man with a newly diagnosed acute myeloid leukemia developed purpuric rash on day 6 after chemotherapy. Skin biopsy on day 8 demonstrated Grover disease. Triamcinolone treatment started on day 10 with subjective improvement on day 15. Read More
Exp Dermatol 2013 Dec;22(12):781-4
Department of Dermatology, University of California, Irvine, CA, USA.
Grover's disease (GD) is a transient or persistent, monomorphous, papulovesicular, asymptomatic or pruritic eruption classified as non-familial acantholytic disorder. Contribution of autoimmune mechanisms to GD pathogenesis remains controversial. The purpose of this study was to investigate antibody-mediated autoimmunity in 11 patients with GD, 4 of which were positive for IgA and/or IgG antikeratinocyte antibodies by indirect immunofluorescence. Read More
Nefrologia 2013 ;33(4):608-9
Ann Pathol 2013 Jun 31;33(3):193-5. Epub 2013 May 31.
Département de pathologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
Eur J Dermatol 2013 May-Jun;23(3):424-5
Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Am J Dermatopathol 2014 Sep;36(9):746-50
*College of Human Medicine, Michigan State University, Grand Rapids, MI; Departments of †Dermatopathology, ‡Dermatology, and §Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA; ¶Harvard Combined Dermatology Residency Training Program, Boston, MA; and ‖Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
Two cases of a pseudoherpetic variant of Grover disease are presented. The first patient was a 60-year-old woman who had high fevers in combination with right lower lobe pneumonia. She developed an itchy papulovesicular rash on her back and upper abdomen. Read More
Dermatol Surg 2013 Jun 5;39(6):960-1. Epub 2013 Apr 5.
Am J Dermatopathol 2014 Apr;36(4):358-9
Department of Dermatology, University of Texas Southwestern Medical School, Dallas, Texas Dermpath Diagnostics Cockerell and Associates, Dallas, Texas Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Case Rep Transplant 2012 20;2012:126592. Epub 2012 Dec 20.
Division of Cardiac Surgery, IRCCS San Matteo Hospital Foundation, University of Pavia School of Medicine, 27100 Pavia, Italy ; U.O. Medicina Interna, Policlinico di Monza, Monza, Italy.
Grover's disease is a transient acantholytic dermatosis of unknown cause, manifesting clinically as a papular skin eruption that is usually located on the anterior chest and abdomen. Histologically characterized by an acantholytic pattern, it has been associated with numerous disorders, including hematologic malignancies, chronic renal failure, and HIV infection, as well as with chemotherapy and bone marrow and/or kidney transplant. Evaluation of followup and treatment is often complicated by spontaneous remission and the occasionally fluctuant course of the disease. Read More
Lancet Oncol 2013 Jan;14(1):e11-8
Department of Dermatology, Westmead Hospital, Sydney, NSW, Australia.
The RAF inhibitors vemurafenib and dabrafenib are emerging as the standard of care for Val600 BRAF-mutant metastatic melanoma. These drugs have shown clinical benefit over the standard care (dacarbazine); however, they are associated with frequent cutaneous adverse events, which can be concerning to the patient and their physician. Herein, we review the range of cutaneous disorders that seem to be induced by RAF inhibitors, including cutaneous squamous-cell carcinoma, hyperkeratotic lesions, Grover's disease, keratosis pilaris-like reactions, and photosensitivity. Read More
Australas J Dermatol 2012 Nov;53(4):315-6
Dermatology 2012 12;225(2):183-7. Epub 2012 Oct 12.
Department of Dermatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan.
Grover's disease is an acquired dermatosis of unknown cause histopathologically characterized by the presence of acantholysis. We report an 83-year-old Japanese man who showed multiple pruritic papular lesions distributed bilaterally along Blaschko lines, necessitating the exclusion of segmental Darier's disease. No mutations in ATP2A2, ATP2C1 or keratin 5 genes were found both in the lesional skin and in peripheral leukocytes, suggesting that putative pathogenesis of Grover's disease is distinct from those of other acantholytic dermatoses. Read More
Int J Dermatol 2012 Nov;51(11):1389-91
Australas J Dermatol 2013 Nov 26;54(4):e88-91. Epub 2012 Sep 26.
Skin and Cancer Foundation Australia, Darlinghurst, New South Wales, Australia.
The case of a 73-year old man with herpes simplex and staphylococcus aureus infection complicating established Grover's disease is presented. This was treated successfully with valaciclovir. While reports of bacterial and herpetic infections complicating other acantholytic diseases, such as Darier's disease, have been published previously, only one publication to date shows herpes simplex infection in Grover's disease. Read More
Arch Dermatol 2012 Aug;148(8):966-8
Br J Dermatol 2012 Nov 5;167(5):1153-60. Epub 2012 Oct 5.
Department of Dermatology, Westmead Hospital, Westmead, NSW 2145, Australia.
Background: Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma carrying relevant oncogenic mutations. Cutaneous reactions are frequent and significant. We conducted a systematic prospective dermatological review of all patients enrolled at a single institution in the phase I/II clinical trial of the mutant BRAF inhibitor dabrafenib (GSK2118436). Read More
Hautarzt 2012 Jun;63(6):487-9
Universitäts-Hautklinik Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.
Focal, mostly suprabasal acantholyis with development of dyskeratotic keratinocytes are typical histological features of Grover's disease. The histological distinction between other forms of acantholytic dermatoses is often difficult. A combined assessment of the histological findings and the clinical symptoms often allows a clear diagnosis. Read More
JAAPA 2012 Apr;25(4):22
Dawkins Dermatology Clinic, Oklahoma City, Oklahoma, USA.