266 results match your criteria Transient Acantholytic Dermatosis


Usefulness of in-vivo reflectance confocal microscopy in patient with nivolumab induced Grover disease.

Ital J Dermatol Venerol 2022 08;157(4):386-387

Section of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy -

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Bullous Grover's Disease in a Chinese Tibetan Adolescent: A Case Report.

Clin Cosmet Investig Dermatol 2022 17;15:1371-1376. Epub 2022 Jul 17.

Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.

Grover's disease (GD), also known as Transient acantholytic dermatosis, has no typical clinical rash features. It usually occurs in elderly white men but very rarely in China. This is a disease of acantholysis and dyskeratosis, which is usually considered to be spontaneous remission. Read More

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Subcorneal pustular dermatosis-type IgA pemphigus associated with multiple myeloma: A case report and literature review.

J Dermatol 2022 Jul 15. Epub 2022 Jul 15.

Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.

Immunoglobulin A (IgA) pemphigus, also known as intercellular IgA dermatosis, is a rare autoimmune bullous disease presenting with IgA anti-keratinocyte cell surface autoantibodies. Concomitant lymphoproliferative disorders have been reported in IgA pemphigus, including IgA monoclonal gammopathy of undetermined significance and IgA type multiple myeloma (MM). A 35-year-old Japanese woman with a 3-year history of pruritic papulovesicles on her lower legs and trunk was referred to our department. Read More

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Management and Treatment of Grover's Disease: A Case Report and Review of Literature.

Cureus 2022 Apr 12;14(4):e24082. Epub 2022 Apr 12.

Family Medicine, Lake Erie College of Osteopathic Medicine, Jacksonville, USA.

This case report details a rare case of Grover's disease in an 80-year-old Caucasian male complaining of a rash across his chest over the last three to four months. The patient has a past medical history of essential hypertension, hyperlipidemia, osteoarthritis of the knee, chronic gastroesophageal reflux disease (GERD), supraventricular tachycardia, status post prostate cancer, and restless legs syndrome. During his initial evaluation, he was found to have a pruritic, erythematous, papular rash most notably along his upper trunk and chest. Read More

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Transient Acantholytic Dermatosis: New Dermatoscopic Features.

Indian J Dermatol 2021 Nov-Dec;66(6):683-685

Department of Pathology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey. E-mail:

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A case of Grover disease treated with Dupilumab: Just serendipity or a future perspective?

Dermatol Ther 2022 05 22;35(5):e15429. Epub 2022 Mar 22.

UOC Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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Acantholytic Dyskeratosis Post-COVID Vaccination.

Am J Dermatopathol 2022 Jun 15;44(6):e61-e63. Epub 2022 Feb 15.

Department of Dermatology, Tufts University School of Medicine, Boston, MA.

Abstract: Acantholytic dyskeratosis mimicking Grover disease as a cutaneous manifestation of a side effect to the Moderna (mRNA-1273) COVID vaccine is rare with only one documented case in the literature to date. Herein, we present a case of an eruptive, erythematous, vesiculopapular rash developing in a patient after the Moderna vaccine. Histopathology of a representative biopsy [x2, done 8 weeks apart] of the rash revealed similar histopathologic findings of patchy suprabasal acantholysis with dyskeratotic keratinocytes and an underlying inflammatory infiltrate of lymphocytes and neutrophils. Read More

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A Case of Extensive Grover's Disease in a Patient with a History of Multiple Non-Melanoma Skin Cancers.

Case Rep Dermatol 2021 Sep-Dec;13(3):553-557. Epub 2021 Dec 7.

Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.

We report on a 69-year-old man who presented with itching and erythematous papules on his torso and extremities, which were resistant to topical therapy with antibiotics and steroids. Physical examination revealed multiple erythematous papules on his back, neckline, and lower extremities. The lesions had appeared 4 years earlier and usually worsened with heat or extensive sweating. Read More

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December 2021

Clinicopathological correlation of transient acantholytic dermatosis: A case report.

Exp Ther Med 2022 Feb 28;23(2):173. Epub 2021 Dec 28.

Department of Dermatology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.

Transient acantholytic dermatosis (TAD) is a benign, non-familial, non-immune mediated acantholytic disorder of unknown etiology. The presence of polymorphous, unorganized, pruritic lesions on the trunk, associated with focal acantholysis and dyskeratosis, resembles a wide variety of dermatoses. The etiology of TAD (also known as Grover's disease) is unknown, and the success of treatment relies on the correct identification of the disease; however, some cases are refractory to all forms of therapy. Read More

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February 2022

A rare case of scrofuloderma along with lupus vulgaris.

Dermatol Reports 2021 Nov 29;13(3):8993. Epub 2021 Jul 29.

Department of Dermatology, Venereology and Allergology, Hospital Brunico, Brunico.

Cutaneous forms of tuberculosis are rare, comprising about 1-1.5% of all cases, and show a wide range of clinical manifestations. Here we present a case of a patient with left cervical ulcerated lymphadenopathy associated with a violaceous plaque in the area of the manubrium of sternum. Read More

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November 2021

A Rare Case of Transient Acantholytic Dermatosis (AKA. Grover's Disease) with Concomitant Pediculosis Pubis: An Atypical Presentation and First Documented Case Report.

Dermatopathology (Basel) 2021 Oct 22;8(4):502-508. Epub 2021 Oct 22.

Department of Dermatology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

A 66-year-old male presented with a one-month history of persistent pruritic eruptions distributed mainly on the trunk. A punch biopsy from the left upper abdomen revealed focal acantholytic dyskeratosis with mixed inflammatory infiltrate in the dermis composed of numerous eosinophils. Grover's disease was diagnosed based on the clinical and histopathological findings. Read More

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October 2021

Drug-induced Grover's disease: a case report and review of the literature.

Int J Dermatol 2022 May 24;61(5):591-594. Epub 2021 Jul 24.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.

Background: Grover's disease (GD) is a relatively rare transient dermatosis that can be idiopathic or acquired. Acquired GD may occur secondary to internal triggers such as medications and malignancies and external factors such as friction.

Objective: The purpose of this report is to describe the clinical and histological presentation of drug-induced Grover's disease (DIGD) and discuss potential pathogenic mechanisms. Read More

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Transient dermatoses: Leaving a lasting memory.

Indian J Dermatol Venereol Leprol 2022 Mar-Apr;88(2):265-267

Department of Dermatology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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Reply to: Case of Bullous Grover Disease.

Am J Dermatopathol 2021 12;43(12):1004-1005

Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI.

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December 2021

Case for diagnosis. Atypical Grover's disease.

An Bras Dermatol 2021 Mar-Apr;96(2):234-236. Epub 2021 Feb 2.

Dermopathology Section, Pathology Service, Hospital Clínico Universidad de Chile, Santiago, Chile.

A 55-year-old male presented with an eight-month history of erythematous papules and plaques with demarcated areas of spared skin on his trunk, upper extremities, neck, and face. Grover's disease is a rare, acquired disorder of unknown origin, which is classically characterized by the appearance of erythematous papules on the upper trunk that are usually transient. As in the present case, there are reports of atypical disease, with facial involvement, pityriasis rubra pilaris-like lesions, and a more chronic course. Read More

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Treatment of Grover Disease With Dupilumab.

JAMA Dermatol 2021 03;157(3):353-356

Department of Dermatology, University of California, San Francisco.

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Grover Disease Associated With Chemotherapy: Review of Potential Pathophysiology, Current Treatments, and Future Directions.

J Drugs Dermatol 2020 Nov;19(11):1056-1064

Introduction: Transient acantholytic dermatosis has been frequently reported in patients with malignancies. While paraneoplastic cases have rarely been reported, most eruptions occur in the setting of chemotherapeutic agents. Management is based on limited data and primarily with topical steroids and topical emollients. Read More

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November 2020

Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity.

J Clin Med 2020 Oct 12;9(10). Epub 2020 Oct 12.

Dermatology Department, Hospital Clinic of Barcelona, University of Barcelona, Barcelona 08036, Spain.

Background: Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well as on their relationship with the severity of COVID-19 are limited.

Methods And Materials: Retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection in a teaching hospital in Barcelona, Spain, from 1 April to 1 May 2020. Clinical, microbiological and therapeutic characteristics, clinicopathological patterns of skin lesions, and direct immunofluorescence and immunohistochemical findings in skin biopsies were analyzed. Read More

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October 2020

Grover-like skin eruption: another cutaneous manifestation in a COVID-19 patient.

Int J Dermatol 2020 Oct 9;59(10):1290-1292. Epub 2020 Aug 9.

Dermatology Department, Hospital Universitari Son Espases, Palma de Mallorca, Spain.

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October 2020

Grover's disease successfully treated with calcipotriene/betamethasone dipropionate ointment.

Dermatol Ther 2020 11 8;33(6):e14217. Epub 2020 Sep 8.

Department of Dermatology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

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November 2020

Clinical features and treatments of transient acantholytic dermatosis (Grover's disease): a systematic review.

J Dtsch Dermatol Ges 2020 08 7;18(8):826-833. Epub 2020 Aug 7.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Grover's disease (GD) is an itchy acantholytic disorder occurring on the trunk of middle-aged men. Based on the best evidence, this study aimed to provide a summary of the clinical characteristics, disease course and treatments of GD. A systematic review was performed according to PRISMA guidelines for original articles published between 01. Read More

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Cutaneous Immune-Related Adverse Events (irAEs) to Immune Checkpoint Inhibitors: A Dermatology Perspective on Management [Formula: see text].

J Cutan Med Surg 2021 Jan-Feb;25(1):59-76. Epub 2020 Aug 3.

54473507266 Division of Dermatology, McGill University, Montreal, QC, Canada.

Immune checkpoint inhibitors have proven to be efficacious for a broad spectrum of solid organ malignancies. These monoclonal antibodies lead to cytotoxic T-cell activation and subsequent elimination of cancer cells. However, they can also lead to immune intolerance and immune-related adverse event (irAEs) that are new and specific to these therapies. Read More

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October 2021

Case of Bullous Grover Disease.

Am J Dermatopathol 2021 Feb;43(2):141-143

Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL; and.

Abstract: Grover disease is an acquired acantholytic dermatosis affecting middle-aged men, with pruritus being the most commonly associated symptom. Grover disease tends to wax and wane and can last between several months to several years. Although Grover disease is usually papular, we report here a patient who presented with mainly vesicular and bullous lesions on his back originally concerning for folliculitis, contact dermatitis, or disseminated herpes simplex viral infection. Read More

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February 2021

Epidermolytic hyperkeratosis: one more pattern of Grover disease.

Int J Dermatol 2020 Nov 19;59(11):e422-e423. Epub 2020 Jul 19.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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November 2020

Treatment of transient acantholytic dermatosis with liquid nitrogen.

JAAD Case Rep 2020 Apr 25;6(4):341-343. Epub 2020 Mar 25.

Division of Dermatology, Harbor-UCLA Medical Center, Torrance, California.

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BRAF inhibitor and hairy cell leukemia-related transient acantholytic dermatosis.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of New Mexico, School of Medicine, Albuquerque, NM.

Grover disease (GD) is an acquired, nonfamilial, nonimmune mediated, transient or persistent acantholytic dermatosis. Herein, we present a 72-year-old man who had clinical and histopathologic findings of GD following two weeks of treatment with vemurafenib without MEK inhibitor. The patient was successfully treated with topical emollients and a high-potency corticosteroid. Read More

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February 2020

Transient acantholytic dermatosis in a patient with prostate cancer.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Foundation University Medical College, Islamabad.

Transient acantholytic dermatosis (TAD) is a relatively common entity that has been also noted to occur in patients with cancer. Herein, we describe a case of transient acantholytic dermatosis occurring in a patient with a history of prostate cancer status post radiation, now being treated with combination therapy with pembrolizumab and carboplatin-pemetrexed for advanced lung adenocarcinoma. Our case emphasizes the importance of being cognizant of TAD and its associations, particularly in cancer patients. Read More

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February 2020