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    207 results match your criteria Transient Acantholytic Dermatosis

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    Histopathological aspects of cutaneous erythematous-papular eruptions induced by immune checkpoint inhibitors for the treatment of metastatic melanoma.
    Int J Dermatol 2017 May 10;56(5):527-533. Epub 2017 Feb 10.
    Oncodermatology department, CIC, CHU, Nantes, France.
    Background: Immune checkpoint blockade therapy (ICBT) for the treatment of melanoma has led to an important improvement of overall survival in advanced stage patients. However, secondary cutaneous maculopapular eruptions (CMPEs) are frequent and remain poorly characterized.

    Methods: We performed a retrospective analysis of melanoma patients from our institution who developed CMPEs during ICBT. Read More

    Erratum to: A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1.
    J Immunother Cancer 2017 18;5. Epub 2017 Jan 18.
    Department of Melanoma Medical Oncology, University of Texas-MD Anderson Cancer Center, Houston, TX USA.
    [This corrects the article DOI: 10.1186/s40425-016-0157-6.]. Read More

    Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature.
    J Cutan Pathol 2017 May 16;44(5):486-489. Epub 2017 Feb 16.
    Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
    A total of 3 cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All 3 patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all 3 patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in 1 patient, the clinical impression included herpesvirus infection. Read More

    A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1.
    J Immunother Cancer 2016 20;4:55. Epub 2016 Sep 20.
    Department of Melanoma Medical Oncology, University of Texas-MD Anderson Cancer Center, Houston, TX USA.
    Background: Immune related adverse events (irAEs) are common side effects of checkpoint inhibitory (CPI) therapies targeting CTLA-4 and PD-1/PD-L1. Grover's disease is an uncommon dermatologic condition with unclear pathogenesis previously reported as an irAE with ipilimumab.

    Case Presentation: We report an additional case of ipilimumab-induced Grover's disease. Read More

    Paraneoplastic Itch Management.
    Curr Probl Dermatol 2016 23;50:149-54. Epub 2016 Aug 23.
    Paraneoplastic itch occurs as the result of a systemic reaction to an underlying malignancy. Paraneoplastic itch is most commonly associated with lymphoproliferative malignancies and solid tumors that result in cholestasis. Paraneoplastic itch may occur in the absence of a primary rash or in association with dermatologic conditions such as erythroderma, acanthosis nigricans, dermatomyositis, Grover's disease, and eruptive seborrheic keratosis. Read More

    Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy.
    J Immunother Cancer 2016 16;4:47. Epub 2016 Aug 16.
    Cantonal Hospital Baselland, Institute of Pathology, Mühlemattstrasse 11, CH-4410 Liestal, Switzerland.
    Background: Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (PD-L1). Skin toxicity most commonly includes a maculopapular erythematous rash and pruritus. Rarely life threatening complications such as Steven's Johnson syndrome or toxic epidermal necrolysis may occur. Read More

    Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation.
    Australas J Dermatol 2016 Jun 30. Epub 2016 Jun 30.
    Westmead Hospital, Sydney, New South Wales, Australia.
    Cutaneous eruptions in recipients of allogeneic haematopoietic stem cell transplantation (AHSCT) are frequent, and common aetiologies include graft-versus-host disease (GVHD), drug reactions, viral infections and engraftment syndrome. Transient acantholytic dermatosis or Grover's disease has been described in oncology patients and it is rarely reported after AHSCT. However, this benign and self-limiting condition should be histologically distinguished from other, more serious entities, mainly stage IV GVHD, in order to avoid inappropriate treatment with corticosteroids and intensive immunosuppression. Read More

    Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data.
    Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.
    Temple University School of Medicine, Philadelphia, PA, USA.
    Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

    Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

    Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

    Dermoscopy of Grover's disease: Variability according to histological subtype.
    J Dermatol 2016 Aug 19;43(8):937-9. Epub 2016 Feb 19.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Distinguishing Grover's disease from other papular dermatoses is often a troublesome task. According to two relatively recent case reports, dermoscopy may be useful in assisting the diagnosis of such a disorder by showing a peculiar pattern. The aim of this study was to evaluate the dermoscopic features of Grover's disease in a larger series of patients and correlate dermoscopy with histopathological findings. Read More

    [Acantholytic dermatosis in patients treated by vemurafenib: 2 cases].
    Ann Dermatol Venereol 2014 Nov 23;141(11):689-93. Epub 2014 Oct 23.
    Clinique de dermatologie et photobiologie, hôpital Nord, CHU de Grenoble, Cs 10217, boulevard de la-Chantourne-La-Tronche, 38043 Grenoble cedex 9, France.
    Background: Acantholytic dyskeratosis under BRAF inhibitors are dermatological diseases rarely reported to date.

    Patients And Methods: We report 2 cases of acantholytic dyskeratosis, reaching the trunk and the seborrheic zones, not itchy, appeared one month after the introduction of vemurafenib. The histological analysis was typical of a "Grover-like rash" for the 2 patients. Read More

    Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection.
    Dermatol Pract Concept 2014 Oct 31;4(4):21-7. Epub 2014 Oct 31.
    Division of Dermatology, University of California San Diego, San Diego, California.
    Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections.

    Purpose: To review the histologic differential diagnosis of conditions with epithelial and histiocytic multinucleated giant cells-since multinucleated giant cells in the epidermis are not always pathognomonic of a cutaneous herpes virus infection-and to summarize dermatoses in which herpes virus infection has been observed to coexist. Read More

    Cutaneous crystal storing histiocytosis: a report of two cases.
    J Cutan Pathol 2015 Feb 24;42(2):136-43. Epub 2014 Nov 24.
    Department of Anatomical Pathology, Liverpool Hospital, Liverpool, Australia.
    Crystal storing histiocytosis (CSH) is a rare condition where crystals accumulate in the cytoplasm of macrophages and is usually associated with a lymphoplasmacytic neoplasm producing a monoclonal immunoglobulin with kappa light chain. CSH with primary manifestation in the skin is extraordinarily rare and limited to four case reports in the literature. Here we present two cases of cutaneous CSH. Read More

    Malassezia skin diseases in humans.
    G Ital Dermatol Venereol 2013 Dec;148(6):609-19
    Division of Dermatology Department of Surgery and Translational Medicine University of Florence, Florence, Italy -
    Although Malassezia yeasts are a part of the normal microflora, under certain conditions they can cause superficial skin infection, such as pityriasis versicolor (PV) and Malassezia folliculitis. Moreover the yeasts of the genus Malassezia have been associated with seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and, less commonly, with confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis. The study of the clinical role of Malassezia species has been surrounded by controversy due to the relative difficulty in isolation, cultivation, and identification. Read More

    Pruritus in the older patient: a clinical review.
    JAMA 2013 Dec;310(22):2443-50
    Department of Dermatology, University of California, San Francisco.
    Importance: Pruritus is a common problem among elderly people and, when severe, causes as much discomfort as chronic pain. Little evidence supports pruritus treatment, limiting therapeutic possibilities and resulting in challenging management problems.

    Objectives: To present the evidence on the etiology, diagnosis, and treatment of pruritus in the elderly and, using the best available evidence, provide an approach for generalist physicians caring for older patients with pruritus. Read More

    Grover disease (transient acantholytic dermatosis) in acute myeloid leukemia on FDG PET/CT.
    Clin Nucl Med 2014 Feb;39(2):e173-5
    From the Departments of *Radiology, and †Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.
    A 48-year-old man with a newly diagnosed acute myeloid leukemia developed purpuric rash on day 6 after chemotherapy. Skin biopsy on day 8 demonstrated Grover disease. Triamcinolone treatment started on day 10 with subjective improvement on day 15. Read More

    Is Grover's disease an autoimmune dermatosis?
    Exp Dermatol 2013 Dec;22(12):781-4
    Department of Dermatology, University of California, Irvine, CA, USA.
    Grover's disease (GD) is a transient or persistent, monomorphous, papulovesicular, asymptomatic or pruritic eruption classified as non-familial acantholytic disorder. Contribution of autoimmune mechanisms to GD pathogenesis remains controversial. The purpose of this study was to investigate antibody-mediated autoimmunity in 11 patients with GD, 4 of which were positive for IgA and/or IgG antikeratinocyte antibodies by indirect immunofluorescence. Read More

    Pseudoherpetic grover disease: report of 2 cases and review of the literature.
    Am J Dermatopathol 2014 Sep;36(9):746-50
    *College of Human Medicine, Michigan State University, Grand Rapids, MI; Departments of †Dermatopathology, ‡Dermatology, and §Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA; ¶Harvard Combined Dermatology Residency Training Program, Boston, MA; and ‖Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
    Two cases of a pseudoherpetic variant of Grover disease are presented. The first patient was a 60-year-old woman who had high fevers in combination with right lower lobe pneumonia. She developed an itchy papulovesicular rash on her back and upper abdomen. Read More

    Grover's Disease after Heart Transplantation: A Case Report.
    Case Rep Transplant 2012 20;2012:126592. Epub 2012 Dec 20.
    Division of Cardiac Surgery, IRCCS San Matteo Hospital Foundation, University of Pavia School of Medicine, 27100 Pavia, Italy ; U.O. Medicina Interna, Policlinico di Monza, Monza, Italy.
    Grover's disease is a transient acantholytic dermatosis of unknown cause, manifesting clinically as a papular skin eruption that is usually located on the anterior chest and abdomen. Histologically characterized by an acantholytic pattern, it has been associated with numerous disorders, including hematologic malignancies, chronic renal failure, and HIV infection, as well as with chemotherapy and bone marrow and/or kidney transplant. Evaluation of followup and treatment is often complicated by spontaneous remission and the occasionally fluctuant course of the disease. Read More

    Cutaneous toxicities of RAF inhibitors.
    Lancet Oncol 2013 Jan;14(1):e11-8
    Department of Dermatology, Westmead Hospital, Sydney, NSW, Australia.
    The RAF inhibitors vemurafenib and dabrafenib are emerging as the standard of care for Val600 BRAF-mutant metastatic melanoma. These drugs have shown clinical benefit over the standard care (dacarbazine); however, they are associated with frequent cutaneous adverse events, which can be concerning to the patient and their physician. Herein, we review the range of cutaneous disorders that seem to be induced by RAF inhibitors, including cutaneous squamous-cell carcinoma, hyperkeratotic lesions, Grover's disease, keratosis pilaris-like reactions, and photosensitivity. Read More

    Grover's disease following multiple bilateral Blaschko lines: a rare clinical presentation with genetic and electron microscopic analyses.
    Dermatology 2012 12;225(2):183-7. Epub 2012 Oct 12.
    Department of Dermatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan.
    Grover's disease is an acquired dermatosis of unknown cause histopathologically characterized by the presence of acantholysis. We report an 83-year-old Japanese man who showed multiple pruritic papular lesions distributed bilaterally along Blaschko lines, necessitating the exclusion of segmental Darier's disease. No mutations in ATP2A2, ATP2C1 or keratin 5 genes were found both in the lesional skin and in peripheral leukocytes, suggesting that putative pathogenesis of Grover's disease is distinct from those of other acantholytic dermatoses. Read More

    Grover's disease secondarily infected with herpes simplex virus and Staphylococcus aureus: case report and review.
    Australas J Dermatol 2013 Nov 26;54(4):e88-91. Epub 2012 Sep 26.
    Skin and Cancer Foundation Australia, Darlinghurst, New South Wales, Australia.
    The case of a 73-year old man with herpes simplex and staphylococcus aureus infection complicating established Grover's disease is presented. This was treated successfully with valaciclovir. While reports of bacterial and herpetic infections complicating other acantholytic diseases, such as Darier's disease, have been published previously, only one publication to date shows herpes simplex infection in Grover's disease. Read More

    Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanoma.
    Br J Dermatol 2012 Nov 5;167(5):1153-60. Epub 2012 Oct 5.
    Department of Dermatology, Westmead Hospital, Westmead, NSW 2145, Australia.
    Background: Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma carrying relevant oncogenic mutations. Cutaneous reactions are frequent and significant. We conducted a systematic prospective dermatological review of all patients enrolled at a single institution in the phase I/II clinical trial of the mutant BRAF inhibitor dabrafenib (GSK2118436). Read More

    [Pruritic submammary papular lesions].
    Hautarzt 2012 Jun;63(6):487-9
    Universitäts-Hautklinik Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.
    Focal, mostly suprabasal acantholyis with development of dyskeratotic keratinocytes are typical histological features of Grover's disease. The histological distinction between other forms of acantholytic dermatoses is often difficult. A combined assessment of the histological findings and the clinical symptoms often allows a clear diagnosis. Read More

    Evaluation of clinical and histopathologic/direct immunofluorescence diagnosis in autoimmune vesiculobullous dermatitis: utility of direct immunofluorescence.
    Turk Patoloji Derg 2012 ;28(1):11-6
    Department of Pathology, Dokuz Eylül University, Faculty of Medicine, İzmir, Turkey.
    Objective: Autoimmune bullous diseases are heterogeneous diseases and the differentiation between the various bullous disease is important for treatment and prognosis. Direct immunofluorescence microscopy is still the gold standard in differentiating these diseases. Our aim was to determine the diagnostic accordance between clinical and histopathological/direct immunofluorescence diagnosis of patients with autoimmune vesicolulobullous skin diseases. Read More

    Grover disease (transient acantholytic dermatosis) induced by anastrozole.
    Cutis 2011 Oct;88(4):175-7
    Department of Dermatology, Wright State University, Dayton, Ohio, USA.
    We present the case of a 79-year-old woman with a history of breast cancer who developed Grover disease (transient acantholytic dermatosis) following initiation of an aromatase inhibitor, anastrozole, as adjunctive treatment of her breast cancer. A number of drugs have been associated with this condition; however, to our knowledge, this case is the first report of anastrozole-induced Grover disease. Read More

    A case of pityriasis rubra pilaris with associated focal acantholytic dyskeratosis complicated by Kaposi's varicelliform eruption.
    J Cutan Pathol 2011 Nov 7;38(11):919-22. Epub 2011 Jul 7.
    Section of Dermatopathology, Department of Pathology, University of Virginia, Charlottesville, VA, USA.
    The clinical and histopathological diagnosis of pityriasis rubra pilaris (PRP) can be difficult because clinical findings are often subtle in early stages, and microscopic findings can overlap with those of other skin diseases. Focal acantholytic dyskeratosis (FAD) can rarely be seen in PRP and can mimic Darier's disease, Grover's disease or other disorders characterized by these histopathologic features. Kaposi's varicelliform eruption is a widespread infection due to herpes simplex virus (HSV) types 1 and 2, coxsackievirus A16 or vaccinia virus, occurring in a preexisting dermatosis; only one case has been reported in PRP. Read More

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