161,809 results match your criteria Transfusion Reactions


Inhibition of Glutathione Synthesis via Decreased Glucose Metabolism in Stored RBCs.

Cell Physiol Biochem 2018 7;51(5):2172-2184. Epub 2018 Dec 7.

Department of Immunology, Binzhou Medical University, Yantai,

Background/aims: Although red blood cells (RBCs) transfusions can be lifesaving, they are not without risk. RBCs storage is associated with the abnormal metabolism of glutathione (GSH), which may increase the risk of the oxidative damage of RBCs after transfusion. The responsible mechanisms remain unknown. Read More

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December 2018

Acute lower gastrointestinal bleeding: are STRATE and BLEED scores valid in clinical practice?

Colorectal Dis 2018 Dec 7. Epub 2018 Dec 7.

Hospital Senhora da Oliveira, Gastrenterology Department - Guimarães, Portugal.

Aim: Acute lower gastrointestinal bleeding (ALGIB) is a commongastroenterological emergency. Despite this outcomes are difficult to predict Onlyy STRATE and BLEED scores are readily available. The aim of this study was to identify risk factors for severe ALGIB and access the validity of available scores. Read More

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December 2018

Nucleated red blood cells as a novel indicator of CD34 cell content in umbilical cord blood.

Transfusion 2018 Dec 7. Epub 2018 Dec 7.

Cell Therapy Laboratory, San Diego Blood Bank, San Diego, California.

Background: Umbilical cord blood (UCB) has become an important source of transplantable CD34 hematopoietic progenitor cells. Cord blood banks (CBBs) can increase their efficiency by minimizing the processing of UCB units with low CD34 content, which have a lower likelihood of transplant utilization. We sought to identify a readily available preprocessing metric that would correlate with CD34 cell counts, without the cost of additional analysis. Read More

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December 2018

Treatment-resistant PLA2R-negative membranous nephropathy responsive to low-density lipoprotein apheresis.

J Clin Apher 2018 Dec 10. Epub 2018 Dec 10.

Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.

Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in nondiabetic adults. The antibody most often implicated is the M-type phospholipase A2 receptor (PLA2R) antibody, found in >70% of primary membranous nephropathy cases. First-line therapy is immunosuppressive in nature, but for patients who are treatment-resistant there is a significant risk of end-stage renal disease and mortality. Read More

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December 2018

A dual strategy to optimize hematopoietic progenitor cell collections: validation of a simple prediction algorithm and use of collect flow rates guided by mononuclear cell count.

Transfusion 2018 Dec 7. Epub 2018 Dec 7.

New York Blood Center, Clinical Services, New York, New York.

Background: Previous prediction algorithms to achieve target CD34+ goals have not been widely adopted, with many centers still using a set volume to process for hematopoietic progenitor cell collections. This may be because previous algorithms are challenging to implement. Additionally, no study has yet examined the utility of adjusting the collect flow rate (CFR) based on the donor's preprocedure total mononuclear cell (MNC) count, which correlates with CD34+ yield. Read More

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December 2018

Long noncoding RNA Breast cancer antiestrogen resistance 4 is associated with cancer progression and its significant prognostic value.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Breast cancer antiestrogen resistance 4 (BCAR4) is a novel long noncoding RNA. It was originally identified in a screen for genes responsible for the development of resistance to antiestrogens in breast cancer cells and plays a major role in various tumors. However, the clinical diagnostic role of BCAR4 in tumors is not completely understood. Read More

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December 2018

Preconditioning of umbilical cord-derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice via the CXCR4/CXCL12 axis.

Cell Prolif 2018 Dec 10:e12546. Epub 2018 Dec 10.

Department of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objectives: Transfusion of umbilical cord-derived mesenchymal stem cells (UC-MSCs) is a novel strategy for treatment of various liver diseases. However, the therapeutic effect of UC-MSCs is limited because only a few UC-MSCs migrate towards the damaged regions. In this study, we observed the effects of autophagy on the migration of UC-MSCs in vitro and in a model of liver ischaemia/reperfusion (I/R) injury. Read More

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December 2018

The impact of blood type on transfusion after major emergency abdominal surgery.

Transfusion 2018 Dec 10. Epub 2018 Dec 10.

Center for Surgical Science (CSS), Department of Surgery, Zealand University Hospital, Køge & University of Copenhagen, København, Denmark.

Background: ABO dependent variation in von Willebrand factor (vWF) and factor VIII have an impact on hemostasis. Several contradictory studies have investigated the influence of ABO blood type in surgical hemorrhage. Emergency surgery is associated with an increased risk of perioperative hemorrhage leading to inferior clinical outcomes. Read More

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December 2018

Vaccines for colorectal cancer: an update.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have introduced for detecting CRC in different stages particularly in early stages. Read More

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December 2018

Implementation of the transradial approach as an alternative vascular access for transcatheter aortic valve replacement guidance: Experience from a high-volume center.

Catheter Cardiovasc Interv 2018 Dec 10. Epub 2018 Dec 10.

Ramsay Générale de Santé, Institut Cardiovasculaire Paris Sud, Massy, Paris, France.

Objective: This study sought to assess the potential benefits of the transradial approach (TRA) as an alternative vascular access to the classical contralateral femoral approach for transcatheter aortic valve replacement (TAVR).

Background: Vascular and bleeding complications in TAVR have gradually decreased owing to operator experience and downsizing of the delivery system. However, about 1/4 of vascular access site complications are related to the transfemoral (TF) secondary access. Read More

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December 2018

Platelet storage properties are associated with donor age: in vitro quality of platelets from young donors and older donors with and without Type 2 diabetes.

Vox Sang 2018 Dec 10. Epub 2018 Dec 10.

Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands.

Background And Objectives: Previously it has been shown that platelet (PLT) storage performance is consistent by donor. Differences involved metabolic activity, which might be caused by mitochondrial (dys)function, associated with age and age-related diseases like Type 2 diabetes (T2D). We aimed to test PLTs from young donors in comparison with PLTs from older donors with or without diagnosis for T2D. Read More

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December 2018

Response to Invited Editorial: Intravenous iron use in pregnancy: Ironing out the issues and evidence.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E28-E29

Department of Obstetrics and Maternal/Fetal Medicine, Canberra Hospital and Health Service, Canberra, Australian Capital Territory, Australia.

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December 2018

Progress of polio eradication and containment requirements after eradication.

Authors:
M Steven Oberste

Transfusion 2018 Dec;58 Suppl 3:3078-3083

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Wild poliovirus (WPV) is nearing eradication, and only three countries have never interrupted WPV transmission (Pakistan, Afghanistan, and Nigeria). WPV2 was last detected in 1999, and it was declared eradicated in 2015. WPV3 has not been detected since 2012. Read More

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December 2018

Longitudinal changes in measles antibody titers in plasma donors and minimum antibody levels of immunoglobulin products for treatment of primary immunodeficiency.

Transfusion 2018 Dec;58 Suppl 3:3065-3071

InflaRx, Jena, Germany.

Background: To ensure that immunoglobulin (Ig) products have adequate functional antibody, the US Food and Drug Administration (FDA) requires that Ig lots contain minimum levels of measles neutralizing antibody; the current minimum is 0.48 x US Reference Ig 176.

Study Design And Methods: In the first part of the study, measles antibody titers were measured in donor plasma samples collected in 2007, 2011, and 2017. Read More

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December 2018

Continued use of poliovirus after eradication: hyper-attenuated strains as a safe alternative for release testing of human immunoglobulins.

Transfusion 2018 Dec;58 Suppl 3:3084-3089

Global Pathogen Safety, Vienna, Austria.

Background: Wild-type poliovirus may be eradicated soon and under WHO GAPIII guidance, laboratory use will be discontinued or subject to strict containment. Per US Code of Federal Regulations, however, immunoglobulin lot release testing will still require use of replicating poliovirus. The suitability of S19 hyper-attenuated and apathogenic poliovirus strains as alternatives to the currently used wild-type virus in such a release assay was investigated. Read More

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December 2018

Measuring quantity and function of pneumococcal antibodies in immunoglobulin products.

Transfusion 2018 Dec;58 Suppl 3:3114-3120

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Immunoglobulin replacement therapy is a cornerstone of the treatment of primary immunodeficiencies. Preparations used for replacement therapy are processed by purifying immunoglobulins from large pools of plasma, which were obtained from healthy donors. The constituent antibodies in these products depend on the immune history of the donor pool as well as manufacturing processes that differ among manufacturers. Read More

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December 2018

Overview of antibody-mediated immunity to S. pneumoniae: pneumococcal infections, pneumococcal immunity assessment, and recommendations for IG product evaluation.

Transfusion 2018 Dec;58 Suppl 3:3106-3113

Regional Immunology Service, The Royal Hospitals, Belfast Health & Social Care Trust and Queen's University Belfast, Belfast, UK.

Streptococcus pneumoniae (S. pneumoniae) strains colonize the nasopharynx and can cause mucosal infections in the upper airway and middle ear, pneumonias, and invasive infections like bacteremia, sepsis, and meningitis. Over 90 serotypes, defined by the structure of their capsular polysaccharides, are known. Read More

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December 2018

Assuring immune globulin potency in a world of changing pathogen challenges.

Authors:
Dorothy E Scott

Transfusion 2018 Dec;58 Suppl 3:3121-3124

Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

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December 2018

Immune globulin potency: challenges and opportunities.

Authors:
Dorothy E Scott

Transfusion 2018 Dec;58 Suppl 3:3051-3053

Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

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December 2018

Immunoglobulins and virus antibody titers: of past needs, current requirements, and future options.

Transfusion 2018 Dec;58 Suppl 3:3090-3095

Global Pathogen Safety, Shire (previously Baxter BioScience, Baxalta), Vienna, Austria.

Background: Immunoglobulins (Igs) have been in clinical use for almost 70 years, and early on were also used in conjunction with exposure to the measles virus or polio virus. The US regulations that describe functional Ig lot release thus require the demonstration of minimum antibody titers against these two viruses, although the use of vaccines has now dramatically reduced their incidence. The lower clinical importance of these viruses raises the question of whether other virus antibodies might be more informative for patients with immunodeficiency. Read More

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December 2018

Antibodies to vaccine antigens in pooled polyclonal human IgG products.

Authors:
Melvin Berger

Transfusion 2018 Dec;58 Suppl 3:3096-3105

Global Medical Affairs, CSL Behring, LLC, King of Prussia, Pennsylvania.

Immune-deficient patients depend on the antibodies in pooled human immunoglobulin G (IgG) preparations to remain free from serious infections. The potency of IgG preparations is therefore an ongoing concern. The use of pooled IgG to prevent infection is based on the concept that healthy adults have recovered from infections earlier in life and maintain relatively high antibody titers. Read More

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December 2018

Humoral immunodeficiencies: conferred risk of infections and benefits of immunoglobulin replacement therapy.

Transfusion 2018 Dec;58 Suppl 3:3056-3064

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Primary immunodeficiency (PID) diseases result from genetic defects of the immune system that increase a patient's susceptibility to infections. The types of infections that occur in patients with PID diseases are dictated largely by the nature of the immunodeficiency, which can be defined by dysfunction of cellular or humoral defenses. An increasing number of PID diseases, including those with both cellular and humoral defects, have antibody deficiency as a major feature, and as a result can benefit from immunoglobulin replacement therapy. Read More

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December 2018

Genetic factors influencing hemoglobin levels in 15,567 blood donors: results from the Danish Blood Donor Study.

Transfusion 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Immunology, Capital Region, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Blood donors have an increased risk of low hemoglobin (Hb) levels due to iron deficiency. Therefore, knowledge of genetic variants associated with low Hb could facilitate individualized donation intervals. We have previously reported three specific single-nucleotide polymorphisms that were associated with ferritin levels in blood donors. Read More

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December 2018

Prognosis of autoimmune hemolytic anemia in critically ill patients.

Ann Hematol 2018 Dec 10. Epub 2018 Dec 10.

Medical Intensive Care Unit, Saint-Louis Teaching Hospital, AP-HP, Paris, France.

Patients with autoimmune hemolytic anemia (AIHA) may require intensive care unit (ICU) admission. In order to describe the characteristics of AIHA patients in ICU and identify prognosis factors, clinical and biological data from 44 patients admitted in one ICU between 2002 and 2015 were retrospectively analyzed. The main reasons for ICU admission were profound anemia without any organ failure in 19 patients (either for safer transfusion or continuous monitoring only). Read More

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December 2018

[Necrotizing esophagitis by stress-cardiomyopathy with right ventricular insufficiency].

Med Klin Intensivmed Notfmed 2018 Dec 10. Epub 2018 Dec 10.

Klinik für Gastroenterologie, Endokrinologie, Diabetologie und Allgemeine Innere Medizin, Klinikum Kassel, Kassel, Deutschland.

Acute necrotizing esophagitis ("black esophagus") is defined as complete necrosis of the esophageal mucosa, which typically affects the entire circumference. We report a case of a healthy 62-year-old woman, who became hemodynamically unstable due to stress cardiomyopathy with acute right heart failure. Transfusion-dependent anemia occurred 24 h later and an upper gastrointestinal endoscopy revealed a black discoloured mucosa of the distal esophagus. Read More

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December 2018

Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan.

Int J Hematol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan.

Recent advances in intensive chemo- and immunotherapy have contributed to the outcome of hemophagocytic lymphohistiocytosis (HLH); however, the prognosis of HLH in children differs by HLH subtype. In Japan, secondary HLH, particularly Epstein-Barr virus-associated HLH (EBV-HLH), is the most common HLH subtype. The prognosis of HLH has improved in recent years. Read More

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December 2018

Overexpression of SMN2 Gene in Motoneuron-Like Cells Differentiated from Adipose-Derived Mesenchymal Stem Cells by Ponasterone A.

J Mol Neurosci 2018 Dec 7. Epub 2018 Dec 7.

Applied Cell Sciences and Tissue Engineering Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cell therapy and stem cell transplantation strategies have provided potential therapeutic approaches for the treatment of neurological disorders. Adipose-derived mesenchymal stem cells (ADMSCs) are abundant adult stem cells with low immunogenicity, which can be used for allogeneic cell replacement therapies. Differentiation of ADMSCs into acetylcholine-secreting motoneurons (MNs) is a promising treatment for MN diseases, such as spinal muscular atrophy (SMA), which is associated with the level of SMN1 gene expression. Read More

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December 2018

International external quality assurance of JAK2 V617F quantification.

Ann Hematol 2018 Dec 8. Epub 2018 Dec 8.

Department of Hematology, Zealand University Hospital, Roskilde, Denmark.

External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in methodology. Results cannot be expected to be more accurate than limits of the technology used, and it is essential to recognize factors causing substantial outlier results. Read More

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December 2018

Quality Improvement in Transfusion Practice of Orthotopic Liver Transplantation Reduces Blood Utilization, Length of Hospital Stay, and Cost.

Am J Clin Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.

Objectives: Orthotopic liver transplantation (OLT) can require substantial usage of blood products. Higher rates of transfusion have been associated with increased length of hospital stay, higher rates of infection, graft failure, and mortality. This study was a retrospective analysis to assess the impact of quality improvement interventions in OLT. Read More

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December 2018

Evidence that ITGB3 promoter variants increase serotonin blood levels by regulating platelet serotonin transporter trafficking.

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Interdepartmental Program "Autism 0-90", "Gaetano Martino" University Hospital, University of Messina, Italy.

Elevated serotonin (5-HT) blood levels, the first biomarker identified in autism research, has been consistently found in 20-30% of patients with Autism Spectrum Disorder (ASD). Hyperserotonemia is mainly due to greater 5-HT uptake into platelets, mediated by the 5-HT transporter (SERT) located at the platelet plasma membrane. The protein complex involved in platelet SERT trafficking and externalization includes integrin β3, the beta subunit of the platelet membrane adhesive GP IIb/IIIa. Read More

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December 2018

[Syphilis epidemiological report. Chile, 2016].

Rev Chilena Infectol 2018 ;35(3):284-296

División de Planificación Sanitaria, Ministerio de Salud de Chile, Chile.

Syphilis is produced by Treponema pallidum, which is acquired mainly through sexual contact and transplacental, but can also be acquired by transfusion of contaminated human blood and direct accidental inoculation. The natural history of the infection is characterized by three symptomatic clinical stages: primary, secondary and tertiary syphilis; these last two are preceded by asymptomatic or latent stages of the disease: early latent syphilis and late latent syphilis. This report presents the epidemiological situation of syphilis in Chile up to 2016, using as a method the descriptive analysis of cases that entered surveillance. Read More

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January 2018

[The jurisprudence about blood transfusion and informed consent of Jehovah witnesses].

Rev Med Chil 2018 Jul;146(7):914-917

Programa de Derecho Público, Departamento de Derecho Público, Universidad Diego Portales, Santiago, Chile.

The law N° 20.584 established the informed consent. This could suggest that patients have a right to refuse a blood transfusion. Read More

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Ultrasound for kidney access in percutaneous nephrolithotomy: a contemporary review.

Med Ultrason 2018 Dec;20(4):508-514

Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, Bucharest, Romania, Urologic Surgery, Fundeni Clinical Institute,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Nowadays percutaneous nephrolithotomy (PCNL) is the standard of care for renal staghorn calculus or large (>20 mm) pelvic or caliceal stones, as well as for the failure of other treatment options. This review aims to evaluate the contemporary use of ultrasound imaging in PCNL, by comparing it to conventional fluoroscopy, reviewing data regarding the complication and success rate of nephrostomy tract creation and stone free rate (SFR), as well as data concerning the learning curve for these procedures and cost indicators. The evidence acquired shows that the ultrasound guided access (USGA) is a comparable method with the classic fluoroscopic guided access (FGA), with a similar safety profile, with a significant reduction in radiation exposure, up to radiation free complete PCNL. Read More

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December 2018

Transitory Spontaneous Remission of Myelodysplasia in an Elderly Man while Receiving Intravesical Bacillus Calmette-Guérin for Bladder Cancer: A Case Report and Review of the Literature.

Case Rep Hematol 2018 11;2018:9750532. Epub 2018 Nov 11.

Physician, General Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa 7770199, Santiago, Chile.

Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. We present a patient with transfusion-dependent myelodysplasia whose blood counts normalized during treatment with intravesical BCG for bladder cancer. Read More

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November 2018

Thulium laser enucleation of the prostate (ThuLEP): Results, complications, and risk factors in 139 consecutive cases.

Arab J Urol 2018 Dec 5;16(4):411-416. Epub 2018 Jul 5.

Department of Urology and Men's Health, Al Garhoud Private Hospital, Dubai, United Arab Emirates.

Objectives: To report our experience with the emerging technique of thulium laser enucleation of the prostate (ThuLEP) for the treatment for prostate hyperplasia.

Patients And Methods: Our inclusion criteria were an International Prostate Symptom Score (IPSS) of >15 and a quality-of-life (QoL) score of >3 in patients with confirmed bladder outflow obstruction, no longer responsive to medical therapy, with a significant post-void residual urine volume (PVR; >100 mL), with or without recurrent urinary tract infection and/or acute urinary retention. Patients with neurogenic bladder, urethral strictures, bladder stones, and previously failed transurethral prostate surgery were excluded. Read More

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December 2018

Radical nephrectomy and intracaval thrombectomy for advanced renal cancer with extensive inferior vena cava involvement utilising cardiopulmonary bypass and hypothermic circulatory arrest: Is it worthwhile?

Arab J Urol 2018 Dec 30;16(4):378-385. Epub 2018 Jul 30.

Department of Urology, University Hospital of Wales, Heath Park, Cardiff, UK.

Objective: To report our long-term outcomes of surgical treatment of renal tumours with inferior vena cava (IVC) tumour thrombus above the hepatic veins, utilising cardiopulmonary bypass (CBP) and hypothermic circulatory arrest (HCA), as surgical resection remains the only effective treatment for renal cancers with extensive IVC tumour thrombus.

Patients And Methods: We retrospectively reviewed 48 consecutive patients (median age 58 years) who underwent surgical treatment for non-metastatic renal cancer with IVC tumour thrombus extending above the hepatic veins. Perioperative, histological, disease-free (DFS) and overall survival (OS) data were recorded. Read More

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December 2018

Leptin Functions in Infectious Diseases.

Front Immunol 2018 26;9:2741. Epub 2018 Nov 26.

Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and peripheral tissues. Leptin is secreted by adipose tissue and encoded by the obese () gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Read More

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November 2018

IL-17 in Peritoneal Dialysis-Associated Inflammation and Angiogenesis: Conclusions and Perspectives.

Front Physiol 2018 26;9:1694. Epub 2018 Nov 26.

Department of Medicine I, Nephrology, Transplantation, Medical Intensive Care, University of Witten/Herdecke, Cologne-Merheim Medical Center, Cologne, Germany.

Long-term peritoneal dialysis (PD) is associated with peritoneal membrane remodeling. This includes changes in peritoneal vasculature, which may ultimately lead to inadequate solute and water removal and treatment failure. The potential cause of such alterations is chronic inflammation induced by repeated episodes of infectious peritonitis and/or exposure to bioincompatible PD fluids. Read More

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November 2018

Hematological and biochemical evaluation of β-thalassemia major (βTM) patients in Gaza Strip: A cross-sectional study.

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):18-24

Department of Biology, Faculty of Science, Al Azhar University-Gaza, P O Box 1277, Gaza, Palestine.

Objectives: In Gaza Strip, Palestine, β-thalassemia is a major public health problem where more than 300 β-thalassemia major (βTM) patients are currently being managed at governmental hospitals. We set up to evaluate the hematological and biochemical aspects of our βTM patients at the Gaza European hospital and their correlation with iron overload.

Methods: Our study included 65 transfusion-dependent βTM, as well as 37 apparently healthy subjects as control group. Read More

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December 2018

MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development.

Noncoding RNA Res 2018 Dec 15;3(4):232-242. Epub 2018 Nov 15.

Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD2080, Malta.

Mesenchymal Stem Cells (MSCs) are widely used in therapeutic applications. Their plasticity and predisposition to differentiate into a variety of cell types, including those of the neuronal lineage, makes them ideal to study whether a selection of miRNAs may direct the differentiation of MSCs into neuroblasts or neuroblastoma to mature neurons. Following a short-listing, miR-107, 124 and 381 were selected as the most promising candidates for this differentiation. Read More

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December 2018

Whole Blood Storage in CPDA1 Blood Bags Alters Erythrocyte Membrane Proteome.

Oxid Med Cell Longev 2018 8;2018:6375379. Epub 2018 Nov 8.

Anti-Doping Lab Qatar, Doha, Qatar.

Autologous blood transfusion (ABT) has been frequently abused in endurance sport and is prohibited since the mid-1980s by the International Olympic Committee. Apart from any significant performance-enhancing effects, the ABT may pose a serious health issue due to aging erythrocyte-derived "red cell storage lesions." The current study investigated the effect of blood storage in citrate phosphate dextrose adenine (CPDA1) on the red blood cell (RBC) membrane proteome. Read More

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November 2018

Aging with HIV: what effect on mortality and loss to follow-up in the course of antiretroviral therapy? The IeDEA West Africa Cohort Collaboration.

HIV AIDS (Auckl) 2018 16;10:239-252. Epub 2018 Nov 16.

INSERM, Centre INSERM U1219-Epidémiologie-Biostatistique, Bordeaux, France,

Background: Reporting mortality and lost to follow-up (LTFU) by age is essential as older HIV-positive patients might be at risk of long-term effects of living with HIV and/or taking antiretroviral therapy (ART). As age effects might not be linear and might impact HIV outcomes in the oldest more severely, people living with HIV (PLHIV) aged 50-59 years and PLHIV aged >60 years were considered separately.

Setting: Seventeen adult HIV/AIDS clinics spread over nine countries in West Africa. Read More

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November 2018

Hepatitis E prevalence in French Polynesian blood donors.

PLoS One 2018 7;13(12):e0208934. Epub 2018 Dec 7.

CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre national de référence du virus de l'hépatite E, Toulouse, France.

The HEV seroprevalence in mainland France is elevated (22.4%). In contrast, anti-HEV seroprevalence appears to be lower in Oceania. Read More

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December 2018
1 Read

Bioluminescent reporter assay for monitoring ER stress in human beta cells.

Sci Rep 2018 Dec 10;8(1):17738. Epub 2018 Dec 10.

Departments of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

During type 1 diabetes development, cells in the islets of Langerhans engage adaptive mechanisms in response to inflammatory signals to cope with stress, to restore cellular homeostasis, and to preserve cell function. Disruption of these mechanisms may induce the formation of a repertoire of stress-induced neoantigens, which are critical in the loss of tolerance to beta cells and the development of autoimmunity. While multiple lines of evidence argue for a critical role of the endoplasmic reticulum in these processes, the lack of tools to specifically monitor beta cell stress hampers the development of therapeutic interventions focusing on maintaining endoplasmic reticulum homeostasis. Read More

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December 2018

In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina.

Sci Rep 2018 Dec 7;8(1):17700. Epub 2018 Dec 7.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Retinal degenerative diseases, due to the lack of regeneration systems and self-renewable cells, often lead to visual impairment. Pax6 is a pleiotropic transcription factor and its expression level determines self-renewal status or differentiation of retinal cells. Here, we investigated the fate of simultaneous induction of retinal ganglion cell death and Pax6 overexpression in retro-differentiation of retinal cells and their commitment to re-enter into the cell cycle. Read More

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December 2018

Association between genotype and disease complications in Egyptian patients with beta thalassemia: A Cross-sectional study.

Sci Rep 2018 Dec 7;8(1):17730. Epub 2018 Dec 7.

Radiodiagnosis departments, Zagazig University, Zagazig, Egypt.

In beta thalassemia, the degree of globin chain imbalance is determined by the nature of the mutation of the β-gene. β° refers to the complete absence of production of β-globin on the affected allele. β refers to alleles with some residual production of β-globin. Read More

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December 2018

[Treatment of combined abdominal and pelvic trauma].

Authors:
F I Ibragimov

Khirurgiia (Mosk) 2018 (10):34-38

Sity Clinical Hospital #3, Chair of Surgery, Aliyev Azerbaijan State Institute of Advanced Medical Education, Baku, Azerbaijan.

Aim: To decrease disability and mortality in patients with severe combined pelvic and abdominal trauma via applications of new progressive treatment tactics.

Material And Methods: Retrospective and prospective analysis included 1033 patients with severe combined traumas (SCT) who were treated at the Clinical Hospital #3 in 2009-2015. Patients were divided into 2 groups - control (2009-2010) and main (2011-2015) group. Read More

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January 2018

Functional Outcomes of Subaxial Spine Injuries Managed With 2-Level Anterior Cervical Corpectomy and Fusion: A Prospective Study.

Neurospine 2018 Oct 15. Epub 2018 Oct 15.

Department of Orthopaedics, Indira Gandhi Medical College Shimla, Shimla, India.

Objective: To evaluate the results of operative management of subaxial spine injuries managed with 2-level anterior cervical corpectomy and fusion with a cervical locking plate and autologous bone-filled titanium mesh cage.

Methods: This study included 23 patients with a subaxial spine injury who matched the inclusion criteria, underwent 2-level anterior cervical corpectomy and fusion at our institution between 2013 and 2016, and were followed up for neurological recovery, axial pain, fusion, pseudarthrosis, and implant failure.

Results: According to Allen and Ferguson classification, there were 9 cases of distractive extension; 4 of compressive extension; 3 each of compressive flexion, vertical compression, and distractive flexion; and 1 of lateral flexion. Read More

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October 2018

Role of anesthesiologists in managing perioperative anemia.

Curr Opin Anaesthesiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Anesthesia, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, Muenster, Germany.

Purpose Of Review: Anemia can contribute negatively to a patient's morbidity and mortality. Which treatment options do exist and what role do anesthesiologists play in management of perioperative anemia treatment? This review gives an overview about recent findings.

Recent Findings: Patient Blood Management and standards for the management and treatment of anemia have been established worldwide. Read More

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December 2018

Cardioprotective Effects of Spirulina Therapy in Children With Beta-Thalassemia Major.

J Pediatr Hematol Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Tanta University Hospital, Tanta, Egypt.

Introduction: Cardiac failure in children with Thalassemia major (TM) is the major cause of death due to iron overload. Spirulina is a micro alga with proven anti-inflammatory, antioxidant and may have a cardioprotective effect.

Aim Of The Work: The aim of this study was to evaluate the possible beneficial effect of spirulina supplement in TM children. Read More

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December 2018