27,383 results match your criteria Transfusion Reactions


Abacavir adverse reactions related with HLA-B*57: 01 haplotype in a large cohort of patients infected with HIV.

Pharmacogenet Genomics 2020 May 22. Epub 2020 May 22.

Department of Infectious and Tropical Diseases, University of Brescia.

Objective: Carriage of human leukocyte antigen (HLA)-B*57:01 allele increases the risk of abacavir hypersensitivity reaction. Therefore, since 2008 HIV treatment guidelines recommend HLA-B*57:01 screening before abacavir administration, greatly reducing hypersensitivity reaction rate. However, clinically suspected abacavir-related hypersensitivity reactions are described in allele non-carriers. Read More

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http://dx.doi.org/10.1097/FPC.0000000000000409DOI Listing

Genomic analysis of blood samples with serologic ABO discrepancy identifies 12 novel alleles in a Chinese Han population.

Transfus Med 2020 May 25. Epub 2020 May 25.

Department of Clinical Laboratory, the First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, China.

Objectives: This study aimed at identifying new ABO alleles from155 unrelated blood samples with potential ABO discrepancy in a Chinese Han population of 835 144 donors.

Background: Serological strategies and genotyping are crucial for the precise determination of ABO discrepancy.

Methods: Their ABO phenotypes and plasma glycosyltransferase activity were determined by standard forward and reverse typing and dilution tests. Read More

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http://dx.doi.org/10.1111/tme.12686DOI Listing

rIL-35 prevents murine transfusion-related acute lung injury by inhibiting the activation of endothelial cells.

Transfusion 2020 May 25. Epub 2020 May 25.

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.

Background: Transfusion-related acute lung injury (TRALI) is an important cause of death associated with transfusion, and no specific clinical treatments are available. Endothelial cells are believed to play an important role in the development of TRALI. This study investigated whether IL-35, an endothelial stabilizing cytokine could regulate the severity of antibody-mediated TRALI in vivo. Read More

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http://dx.doi.org/10.1111/trf.15805DOI Listing

Mesenchymal stromal cells; a new horizon in regenerative medicine.

J Cell Physiol 2020 May 26. Epub 2020 May 26.

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

In recent decades, mesenchymal stromal cells (MSCs) biomedical utilizing has attracted worldwide growing attention. After the first report of the human MSCs obtaining from the bone marrow (BM) tissue, these cells were isolated from wide types of the other tissues, ranging from adipose tissue to dental pulp. Their specific characteristics, comprising self-renewality, multipotency, and availability accompanied by their immunomodulatory properties and little ethical concern denote their importance in the context of regenerative medicine. Read More

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http://dx.doi.org/10.1002/jcp.29803DOI Listing

Development and validation of donor adverse reaction severity grading tool: enhancing objective grade assignment to donor adverse events.

Transfusion 2020 May 25. Epub 2020 May 25.

Department of Research, AABB, Bethesda, Maryland, USA.

Background: Uniform and consistent reporting and comparison of donor adverse events (DAEs) and severity are well-recognized challenges for donor hemovigilance (DHV). While the 2014 Standard for Surveillance of Complications Related to Blood Donation (SSCRBD), developed by hemovigilance experts from AABB, the International Society of Blood Transfusion, and International Hemovigilance Network, established the DAE definitions, no specific guidelines were provided to grade severity. A group of subject matter experts developed the Severity Grading Tool for Blood Donor Adverse Events (SGT) to enhance objective assignment of severity and conducted a study to validate the tool. Read More

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http://dx.doi.org/10.1111/trf.15830DOI Listing

Acute monoblastic leukemia in a feline leukemia virus-negative cat.

J Vet Med Sci 2020 May 22. Epub 2020 May 22.

Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine.

A 12-year-old female domestic short-haired cat was presented due to weight loss, anorexia, and tachypnea. Complete blood count revealed severe anemia, leukocytosis with massive undifferentiated blast cells, and thrombocytopenia. Bone marrow aspiration showed acute myeloid leukemia, subclassified as monoblastic leukemia (M5a) based on the outcomes of the cytochemistry examinations. Read More

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http://dx.doi.org/10.1292/jvms.20-0157DOI Listing

New insights into allergic transfusion reactions and their causal relationships, pathogenesis, and prevention.

Transfusion 2020 May 22. Epub 2020 May 22.

Japanese Red Cross Kinki Block Blood Center, Ibaraki, Osaka, Japan.

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http://dx.doi.org/10.1111/trf.15845DOI Listing

Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells.

Sci Rep 2020 May 21;10(1):8472. Epub 2020 May 21.

Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Platelet demand has increased around the world. However, the inadequacy of donors, the risk of transfusion-transmitted infections and associated reactions, and the refractory nature of platelet transfusions are among the limitations of allogeneic platelet transfusions. To alleviate these problems, we propose generating platelets in a laboratory that do not induce alloimmunity to human leukocyte antigen (HLA) class I, which is a major cause of immune reaction in platelet transfusion refractoriness. Read More

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http://dx.doi.org/10.1038/s41598-020-65577-xDOI Listing

Documentation errors in transfusion chain: Challenges and interventions.

Transfus Apher Sci 2020 May 13:102812. Epub 2020 May 13.

Section of Hematology and Transfusion Medicine, Aga Khan University, Pakistan. Electronic address:

Background And Objective: There are several steps in transfusion chain where accurate documentation is critical. This study was conducted to evaluate the frequency of documentation errors during transfusion process and to evaluate the effectiveness of interventions in error-management.

Methods /material: This study was conducted at Aga Khan University, Pakistan during 2016-2018. Read More

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http://dx.doi.org/10.1016/j.transci.2020.102812DOI Listing

Global Trigger Tool: Proficient Adverse Drug Reaction Autodetection Method in Critical Care Patient Units.

Indian J Crit Care Med 2020 Mar;24(3):172-178

Department of Orthopedics, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India.

Background: Emergency department (ED) being the most crucial part of hospital, where adverse drug reactions (ADRs) often go undetected. Trigger tools are proficient ADR detection methods, which have only been applied for retrospective surveillance. We did a prospective analysis to further refine the trigger tool application in healthcare settings. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225762PMC

Utilising red cell antigen genotyping and serological phenotyping in sickle cell disease patients to risk-stratify patients for alloimmunisation risk.

Transfus Med 2020 May 20. Epub 2020 May 20.

Hamilton Regional Laboratory Medicine Program, McMaster University, Hamilton, Ontario, Canada.

Background: Alloimmunisation and haemolytic transfusion reactions (HTRs) can occur in patients with sickle cell disease (SCD) despite providing phenotype-matched red blood cell (RBC) transfusions. Variant RBC antigen gene alleles/polymorphisms can lead to discrepancies in serological phenotyping. We evaluated differences between RBC antigen genotyping and phenotyping methods and retrospectively assessed if partial antigen expression may lead to increased risk of alloimmunisation and HTRs in SCD patients at a tertiary centre in Canada. Read More

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http://dx.doi.org/10.1111/tme.12685DOI Listing

Adoption trends of point of issue Verax PGD rapid test for bacterial screening of platelets between 2013 and 2018 among hospitals supplied by the American Red Cross and impact on platelet availability.

Transfusion 2020 May 19. Epub 2020 May 19.

American Red Cross Blood Services, Dedham, Massachusetts.

Background: Point-of-issue tests, such as the Verax Pan Genera Detection (PGD) test, can be used to mitigate the occurrence of septic reactions. Little is known about how widespread the adoption of the PGD test is across US hospitals.

Study Design/methods: The Red Cross hemovigilance database was used to determine the numbers of PGD-positive test results between 2013 and 2018. Read More

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http://dx.doi.org/10.1111/trf.15817DOI Listing

Antibody Production in Murine Polymicrobial Sepsis-Kinetics and Key Players.

Front Immunol 2020 30;11:828. Epub 2020 Apr 30.

Immunology Department, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.

Although antigen-specific priming of antibody responses is impaired during sepsis, there is nevertheless a strong increase in IgM and IgG serum concentrations. Using colon ascendens stent peritonitis (CASP), a mouse model of polymicrobial abdominal sepsis, we observed substantial increases in IgM as well as IgG of all subclasses, starting at day 3 and peaking 2 weeks after sepsis induction. The dominant source of antibody-secreting cells was by far the spleen, with a minor contribution of the mesenteric lymph nodes. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205023PMC

Fluvastatin prevents the development of arthritis in env-pX rats via up- regulation of Rho GTPase-activating protein 12.

Exp Mol Pathol 2020 May 15:104454. Epub 2020 May 15.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan. Electronic address:

The pleiotropic effects of statins, including an antiarthritic potential, have been noted. This study aimed to determine the efficacy of statins on rheumatoid arthritis (RA) and clarify how statins affect its pathogenesis. Fluvastatin (500 μg/kg/day) or vehicle was given per os to env-pX rats, which carry the human T-cell leukemia virus type I env-pX gene and spontaneously develop destructive arthritis mimicking RA, for 30 days. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104454DOI Listing

Evaluation of the procoagulant properties of a newly developed platelet modified lysate product.

Transfusion 2020 May 15. Epub 2020 May 15.

Transfusion Medicine Division, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

Background: Platelet transfusion is associated with logistical problems with the national storage guidelines of platelets. This results in decreased function in vivo as a result of the platelet storage lesion, and complications such as allergic or hemolytic reactions and thrombosis. We evaluated a new, freshly prepared platelet modified lysate (PML) product designed to be more procoagulant than fresh and stored platelets. Read More

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http://dx.doi.org/10.1111/trf.15844DOI Listing

High prevalence of human T-cell leukemia virus type-1b genotype among blood donors in Gabon, Central Africa.

Transfusion 2020 May 15. Epub 2020 May 15.

Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, UMR 3569, CNRS, Paris, France.

Background: The African continent is considered to be the largest endemic area of HTLV-1 infection, with at least several million infected individuals. Systematic screening of blood donors can prevent the transmission of HTLV-1 in blood. Gabon is one of the countries with the highest prevalence of HTLV-1 worldwide, and yet the routine testing of blood donors has still not been introduced. Read More

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http://dx.doi.org/10.1111/trf.15838DOI Listing

Efficacy evaluation of the combination therapy of sorafenib and transarterial chemoembolization for unresectable HCC: a systematic review and meta-analysis of comparative studies.

Ann Transl Med 2020 Apr;8(8):540

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Sorafenib and transarterial chemoembolization (TACE) are the standard treatments recommended by guidelines for unresectable hepatocellular carcinoma (HCC). Although previous studies have shown the combination therapy of sorafenib and TACE to be safe, there is no consensus regarding its efficacy. This systematic review and meta-analysis, which was based on the findings of comparative clinical trials, was conducted to provide up-to-date and comprehensive information about the efficacy of combination therapy versus TACE monotherapy in unresectable HCC. Read More

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http://dx.doi.org/10.21037/atm.2020.02.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214895PMC

Isoagglutinin reduction in intravenous immunoglobulin (IgPro10, Privigen) by specific immunoaffinity chromatography reduces its reporting rates of hemolytic reactions: an analysis of spontaneous adverse event reports.

Transfusion 2020 May 14. Epub 2020 May 14.

CSL Behring, King of Prussia, Pennsylvania, USA.

Background: Hemolysis is an infrequent but recognized and potentially serious adverse effect of intravenous immunoglobulin (IVIG). Relatively elevated hemolysis reporting rates were seen with some IVIG products with high anti-A/B isoagglutinin content, among which IgPro10 (Privigen, CSL Behring). For IgPro10, two isoagglutinin reduction measures were successively implemented: 1) anti-A donor screening and 2) immunoaffinity chromatography (IAC; Ig IsoLo)-based isoagglutinin reduction step included in the production process. Read More

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http://dx.doi.org/10.1111/trf.15846DOI Listing

Impact of using genotyping to predict SERF negative phenotype in Thai blood donor populations.

Blood Res 2020 May 14. Epub 2020 May 14.

National Blood Centre, Thai Red Cross Society, Bangkok, Thailand.

Background: SERF(+) is a high prevalence antigen in the Cromer blood group system that is encoded by a allele. The SERF(-) on red cells is caused by a single nucleotide variation, c.647C>T, in exon 5 of the gene. Read More

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http://dx.doi.org/10.5045/br.2020.2020042DOI Listing

: Preventive and therapeutic effects of morphine and evaluation of treatment parameters of tachyzoites and infected macrophages and in a murine model.

EXCLI J 2020 20;19:514-527. Epub 2020 Apr 20.

Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Common medicines for the treatment of toxoplasmosis have limited efficacy and unwanted side effects. Opiates can effect both innate and cell-mediated immunity and stimulate the immune responses in different parasitic infections. In this work, preventive and therapeutic effects of morphine were evaluated on the tachyzoites of and infected macrophages and in a murine model. Read More

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http://dx.doi.org/10.17179/excli2019-1961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214776PMC

[Effect of high-titer plasma in pediatric patients with severe adenovirus pneumonia].

Zhonghua Er Ke Za Zhi 2020 May;58(5):392-397

Department of Pediatrics, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

To explore the efficacy and safety of high-titer plasma in the treatment of pediatric patients with severe adenovirus pneumonia. The clinical data of 92 pediatric patients with severe adenovirus pneumonia admitted to pediatric intensive care unit (PICU) in Guangzhou Women and Children's Medical Center from January 2016 to October 2019 were retrospectively collected. According to the treatment with or without high-titer plasma, the patients were divided into plasma treatment group (41) and non-plasma treatment group (51). Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20191111-00713DOI Listing

Frequent Transfusion and Specific HLA-DRB1 Alleles Correlate Independently with Miltenberger Blood Group Alloimmunization in Dialysis Patients.

HLA 2020 May 10. Epub 2020 May 10.

Department of Medical Research, E-DA Hospital, Kaohsiung, Taiwan.

Anti-"Mi " is the most frequent irregular RBC antibody in Taiwan due to high prevalence of Miltenberger antigens. Dialysis patients, a special patient group that needs frequent transfusions of RBCs, may have the greatest risk for developing anti-"Mia" antibodies. The aim of this study was to investigate the association between specific HLA-DRB1 alleles and Mi alloimmunization among dialysis patients. Read More

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http://dx.doi.org/10.1111/tan.13924DOI Listing

Multiplex Detection of Viral DNAs in Blood by Colorimetrically Identifying Polymerase Chain Reaction Amplicons with Serial Invasive Reaction Assisted Gold Nanoparticle Probes Assembling.

J Nanosci Nanotechnol 2020 Oct;20(10):6140-6147

Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China.

Detection of blood-borne pathogenic viruses is essential for blood transfusion, and has great significance for epidemiology, as well as clinical practices. Common blood-borne viruses causing infectious diseases include Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency virus (HIV) and Treponema pallidum (TP). Therefore, multiplex detection of these viruses is more in the line with the needs of clinical testing. Read More

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http://dx.doi.org/10.1166/jnn.2020.18122DOI Listing
October 2020

Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products.

J Transl Med 2020 May 8;18(1):191. Epub 2020 May 8.

Center for Cellular Engineering, Department of Transfusion Medicine and Cellular Engineering, NIH Clinical Center, Bethesda, MD, USA.

Background: Genetically engineered T cells have become an important therapy for B-cell malignancies. Measuring the efficiency of vector integration into the T cell genome is important for assessing the potency and safety of these cancer immunotherapies.

Methods: A digital droplet polymerase chain reaction (ddPCR) assay was developed and evaluated for assessing the average number of lenti- and retroviral vectors integrated into Chimeric Antigen Receptor (CAR) and T Cell Receptor (TCR)-engineered T cells. Read More

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http://dx.doi.org/10.1186/s12967-020-02358-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206671PMC

Redirection of transfusion waste and by-products for xeno-free research applications.

J Clin Transl Res 2020 Jan 9;5(2):50-59. Epub 2019 Nov 9.

Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, Msida, MSD2080, Malta.

Background And Aim: Whole blood is processed to derive a red cell concentrate, plasma, and buffy coat (BC) (from which platelets can be further extracted). Unused plasma and BCs are common in most blood establishments and considered a liability. The redirection of these products to xeno-free applications is not complicated or time-consuming and cannot only benefit the research recipients but also the blood establishment suppliers interested in research collaboration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197051PMC
January 2020

Prevalence of Dal blood type and dog erythrocyte antigens (DEA) 1, 4, and 7 in canine blood donors in Italy and Spain.

BMC Vet Res 2020 May 6;16(1):126. Epub 2020 May 6.

Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.

Background: The aim of this study was to determine the prevalence of Dal, and DEA 1, 4, 7 blood types, in a population of canine blood donors from Italy and Spain. Three hundred and twenty blood donor dogs receiving an annual health evaluation were included in the study. DEA 1 blood type was determined using an immunochromatographic strip technique while Dal, DEA 4 and 7 blood types were determined with polyclonal antisera using agglutination on gel columns. Read More

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http://dx.doi.org/10.1186/s12917-020-02351-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204017PMC

The Prevalence of Blood Groups in Domestic Cats in the Saskatoon and Calgary Areas of Saskatchewan and Alberta, Canada.

Front Vet Sci 2020 21;7:160. Epub 2020 Apr 21.

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

The purpose of this study was to evaluate blood types of domestic cats in two cities in Western Canada (Saskatoon, Saskatchewan and Calgary, Alberta), as well as to determine the risk of mismatched transfusion and neonatal isoerythrolysis. Several cat studies around the world have shown variability in the prevalence of blood types in domestic and pedigree cats. Canadian data based on feline blood types is based out of Montreal. Read More

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http://dx.doi.org/10.3389/fvets.2020.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186432PMC

Prolonged operative time increases risk of blood loss and transfusion requirements in revision hip surgery.

Eur J Orthop Surg Traumatol 2020 May 4. Epub 2020 May 4.

Orthopaedic Research Institute, Bournemouth University, 6th Floor, Executive Business Centre, 89 Holdenhurst Road, Bournemouth, BH8 8EB, UK.

Introduction: Revision hip surgery is well documented to have a high association with substantial blood loss and the associated need for a blood transfusion. This exposes the patient to increased risk of transfusion reaction and blood borne infection. There are many strategies to minimize allogeneic transfusion rates in revision surgery such as pre-operative autologous donation, peri-operative tranexamic acid, thrombin sealants, normovolaemic haemodilution, intra-operative blood salvage and the use of post-operative autologous drains. Read More

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http://dx.doi.org/10.1007/s00590-020-02677-4DOI Listing

Intelligent infusion controller with a physiological information feedback function.

Technol Health Care 2020 Apr 24. Epub 2020 Apr 24.

Department of Medical Electronic Engineering, Faculty of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

Background: In hospitals, some problems still exist, such as transfusion reaction that cannot be dealt with in time, medical staff cannot observe the physiological information of the infusion patients in real time, and the infusion speed cannot be controlled smartly.

Objective: To address these problems, we propose a method for intelligent monitoring and designed a controller for dripping speed regulation.

Methods: A photoelectric sensor was used to obtain the heart rate (HR) information, and a PID parameter self-tuning controller based on the fuzzy control principle was developed to establish a multi-stage adaptive control method based on HR feedback. Read More

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http://dx.doi.org/10.3233/THC-209005DOI Listing

Efficacy and Safety of Treatment With Ferric Carboxymaltose in Patients With Cirrhosis and Gastrointestinal Bleeding.

Front Med (Lausanne) 2020 17;7:128. Epub 2020 Apr 17.

Department of Gastroenterology, University Hospital Arnau de Vilanova, Lleida, Spain.

Patients with liver cirrhosis and gastrointestinal bleeding (GIB) often develop anemia. Ferric carboxymaltose (FCM) is an intravenous (i.v. Read More

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http://dx.doi.org/10.3389/fmed.2020.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181670PMC

SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission.

Transfusion 2020 May 2. Epub 2020 May 2.

Institute for Medical Virology, University Hospital, Goethe University, Frankfurt, Germany.

Oral swabs, sputum and blood samples from 18 patients with SARS-CoV-2 infection were examined using real-time reverse transcription polymerase chain reaction (RT-PCR) testing. Whereas oral swabs or sputum from the lower respiratory tract were tested RT-PCR positive in all patients, RNAemia was neither detected in 3 patients without symptoms nor in 14 patients with flu-like symptoms, fever or pneumonia. The only patient with RNAemia suffered from acute respiratory distress syndrome (ARDS) and was artificially ventilated in an intensive care unit. Read More

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http://dx.doi.org/10.1111/trf.15841DOI Listing

A new antigen SUMI carried on glycophorin A encoded by the GYPA*M with c.91A>C (p.Thr31Pro) belongs to the MNS blood group system.

Transfusion 2020 May 1. Epub 2020 May 1.

Japanese Red Cross Central Blood Institute, Tokyo, Japan.

Background: MNS is one of the highly polymorphic blood groups comprising many antigens generated by genomic recombination among the GYPA, GYPB, and GYPE genes as well as by single-nucleotide changes. We report a patient with red blood cell (RBC) antibody against an unknown low-frequency antigen, tentatively named SUMI, and investigated its carrier molecule and causal gene.

Study Design And Methods: Standard serologic tests, including enzyme tests, were performed. Read More

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http://dx.doi.org/10.1111/trf.15828DOI Listing

Comprehensive analysis of hepatitis B virus infections in blood donors in southern China that are surface antigen positive but nucleic acid testing negative.

Transfusion 2020 May 1. Epub 2020 May 1.

Provincial Key Laboratory for Transfusion-transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Chengdu, Sichuan, China.

Background: Hepatitis B virus (HBV) infection is one of the major concerns for the safety of blood transfusion in high-prevalent countries such as in China. Prior studies outside of China have shown hepatitis B surface antigen (HBsAg) false-reactive rate of 0.02% to 0. Read More

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http://dx.doi.org/10.1111/trf.15824DOI Listing
May 2020
3.225 Impact Factor

Caplacizumab for treatment of thrombotic thrombocytopenic purpura in a patient with anaphylaxis to fresh-frozen plasma.

Transfusion 2020 May 1. Epub 2020 May 1.

Diagnostic Laboratories, Versiti Blood Center of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Plasma exchange with plasma replacement has been the mainstay for the treatment of thrombotic thrombocytopenic purpura (TTP) for several decades. Recently an anti-von Willebrand factor (VWF) medication, caplacizumab, has been approved for treatment of TTP when used with plasma exchange. We report a patient with immune-mediated TTP that had an anaphylactic reaction to plasma who was then given caplacizumab daily for 1 week without further plasma exchange therapy with a good clinical and laboratory response. Read More

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http://dx.doi.org/10.1111/trf.15823DOI Listing

Bacterial contamination and septic transfusion reaction rates associated with platelet components before and after introduction of primary culture: experience at a US Academic Medical Center 1991 through 2017.

Transfusion 2020 May 1;60(5):974-985. Epub 2020 May 1.

Department of Pathology and Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Background: The high incidence of septic transfusion reactions (STRs) led to testing being mandated by AABB from 2004. This was implemented by primary culture of single-donor apheresis platelets (APs) from 2004 and prestorage pooled platelets (PSPPs) from 2007.

Study Design/methods: Platelet (PLT) aliquots were cultured at issue and transfusion reactions evaluated at our hospital. Read More

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http://dx.doi.org/10.1111/trf.15780DOI Listing
May 2020
3.225 Impact Factor

Molecular Basis of ABO Variants Including Identification of 16 Novel Subgroup Alleles in Chinese Han Population.

Transfus Med Hemother 2020 Apr 4;47(2):160-166. Epub 2019 Sep 4.

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: The characteristic of ABO blood subgroup is crucial for elucidating the mechanisms of such variant phenotypes and offering useful information in blood transfusion.

Methods: In total, 211 ABO variants including part of available family members were investigated in this study. The phenotypes of these individuals were typed with serologic methods. Read More

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http://dx.doi.org/10.1159/000501862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184853PMC

The Sting of Rejection: Deferring Blood Donors due to Low Hemoglobin Values Reduces Future Returns.

Transfus Med Hemother 2020 Apr 27;47(2):119-128. Epub 2019 May 27.

Blood Transfusion Service, Swiss Red Cross, Schlieren, Switzerland.

Background: Roughly one quarter of short-term temporary deferrals (STTD) of blood donors are low-hemoglobin deferrals (LHD), i.e. STTD due to a hemoglobin (Hb) value falling below a cutoff of 125 g/L for female and 135 g/L for male donors. Read More

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http://dx.doi.org/10.1159/000500679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184835PMC

Two Consecutive Episodes of Severe Delayed Hemolytic Transfusion Reaction in a Sickle Cell Disease Patient.

Case Rep Hematol 2020 14;2020:2765012. Epub 2020 Apr 14.

Department of Haematology, Oslo University Hospital, Oslo, Norway.

Patients with sickle cell disease (SCD) suffer from anemia and painful vaso-occlusive crisis (VOC) and sometimes need blood transfusions. Delayed hemolytic transfusion reaction (DHTR) is a rare life-threatening complication observed in SCD and mimics VOC. We describe a female SCD patient undergoing three surgical procedures during which DHTR developed following the first two. Read More

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http://dx.doi.org/10.1155/2020/2765012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180413PMC

The Effect of Composol Medium on miR-16 Expression during Platelet Storage up to Day 7 at Room Temperature.

Cell J 2021 Jan 22;22(4):542-547. Epub 2020 Apr 22.

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.

Objective: MicroRNAs (miRNAs) are short, noncoding RNAs that play vital roles in gene regulation. It has been shown that storage has an effect on platelet miRNAs. MiR-16 is highly expressed in platelets and it appears to target the genes involved in cell death. Read More

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http://dx.doi.org/10.22074/cellj.2021.6790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211276PMC
January 2021

Blood, Sweat, and Fears: A Novel Mutation Associated With Anaphylaxis and Nonresponse in a Patient With Afibrinogenemia.

J Pediatr Hematol Oncol 2020 Apr 24. Epub 2020 Apr 24.

Baylor College of Medicine.

Congenital afibrinogenemia is a rare disorder characterized by a lack of detectable fibrinogen. The mainstay of treatment for acute bleeding episodes or perioperative management is replacement with fibrinogen concentrate or fibrinogen-containing blood products. The development of neutralizing antibodies and severe allergic reactions to fibrinogen replacement is rarely reported in afibrinogenemia patients. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001812DOI Listing

Blood Group Discrepancies at a Regional Blood Center.

Int J Hematol Oncol Stem Cell Res 2020 Jan;14(1):38-44

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Yazd, Iran.

Blood group testing is an important part of supplying safe blood components in blood transfusion centers. Blood group discrepancy develops when reactions in forward grouping do not correspond with reverse grouping or if the preceding and recent results do not match. This study aimed to evaluate ABO blood group discrepancies among blood donors of Yazd, Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167605PMC
January 2020

Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019.

Int J Infect Dis 2020 Apr 22;95:332-339. Epub 2020 Apr 22.

Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, PR China; Department of Clinical Laboratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, PR China. Electronic address:

Objective: To explore the clinical value of immune-inflammatory markers to assess the severity of coronavirus disease 2019 (COVID-19).

Methods: 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled in this study, and classified into non-severe and severe groups. Demographics, symptoms, underlying diseases and laboratory data were collected and assessed for predictive value. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.04.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195003PMC

[Clinical Efficacy of Low-Dose Bortezomib-Based Triple Combination Therapy in the Treatment of Elderly Multiple Myeloma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):535-539

Department of Hematology, Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China,E-mail:

Objective: To investigate the clinical efficacy and safety of low-dose bortezomib-based triple combination therapy in the treatment of elderly multiple myeloma(MM).

Methods: Fifty-eight patients with elderly multiple myeloma were selected. And according to the drug rigimen the patients were randomly divided into three groups. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.030DOI Listing

Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma.

JCO Glob Oncol 2020 Apr;6:628-638

Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Centre Singapore, Singapore.

Purpose: Cholangiocarcinoma (CCA) remains a disease with poor prognosis and limited therapeutic options. Identification of driver genetic alterations may lead to the discovery of more effective targeted therapies. CCAs harboring fusions have recently demonstrated promising responses to FGFR inhibitors, highlighting their potential relevance as predictive biomarkers. Read More

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http://dx.doi.org/10.1200/GO.20.00030DOI Listing

Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth?

Transfusion 2020 May 21;60(5):1069-1077. Epub 2020 Apr 21.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, NICU, Milan, Italy.

Background: Phlebotomy is among the main determinants of anemia of prematurity. Blood sparing policies endorsed umbilical cord blood (here called placental) as an alternative source for laboratory testing. Little is known on the suitability of placental blood to evaluate neonatal hemostasis of newborn infants. Read More

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http://dx.doi.org/10.1111/trf.15785DOI Listing

An unusual variant glycophorin expressing protease-resistant M antigen encoded by the GYPB-E(2-4)-B hybrid gene.

Vox Sang 2020 Apr 21. Epub 2020 Apr 21.

Japanese Red Cross Central Blood Institute, Tokyo, Japan.

Background And Objectives: MNS is a highly polymorphic blood group comprising 49 antigens recognized by International Society of Blood Transfusion, some of which may have been generated by genomic recombination among the closely linked genes GYPA, GYPB and GYPE. The GYPE gene has an almost identical sequence to GYPA*01 allele in exon 2 (99% homology), which accounts for M antigen. We investigated an unusual glycophorin molecule with protease-resistant M antigen. Read More

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http://dx.doi.org/10.1111/vox.12918DOI Listing

Incompatible erythrocyte transfusion with lipopolysaccharide induces acute lung injury in a novel rat model.

PLoS One 2020 20;15(4):e0230482. Epub 2020 Apr 20.

Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America.

Acute transfusion reactions can manifest in many forms including acute hemolytic transfusion reaction, allergic reaction and transfusion-related acute lung injury. We previously developed an acute hemolytic transfusion reaction rat model mediated by transfusion of incompatible human erythrocytes against which rats have preexisting antibodies resulting in classical complement pathway mediated intravascular hemolysis. In this study, the acute hemolytic transfusion reaction model was adapted to yield an acute lung injury phenotype. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230482PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170260PMC

Establishment and Evaluation of a Novel Method Based on Loop-Mediated Isothermal Amplification for the Rapid Diagnosis of Thalassemia Genes.

Risk Manag Healthc Policy 2020 5;13:303-311. Epub 2020 Apr 5.

Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, People's Republic of China.

Purpose: Currently, thalassemia is commonly detected using gap-polymerase chain reaction (PCR) and deoxyribonucleic acid (DNA) reverse dot blot, which have high requirements of space, instruments, and personnel. Therefore, it is necessary to develop a new method for thalassemia detection with high sensitivity, low cost, and simple and fast operation. In this study, we aimed to design and evaluate a new method for detecting three α-thalassemia genes including -Southeast Asian (SEA), -α3. Read More

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http://dx.doi.org/10.2147/RMHP.S241399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147610PMC

Postoperative but not intraoperative transfusions are associated with respiratory failure after pneumonectomy.

Eur J Cardiothorac Surg 2020 Apr 17. Epub 2020 Apr 17.

Department of Surgery, Division of Thoracic Surgery, University of Toronto, Toronto General Hospital, Toronto, ON, Canada.

Objectives: Transfusion of blood products has been associated with increased risk of post-pneumonectomy respiratory failure. It is unclear whether intraoperative or postoperative transfusions confer a higher risk of respiratory failure. Our objective was to assess the role of transfusions in developing post-pneumonectomy respiratory failure. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa107DOI Listing

Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2)-infected pneumonia (COVID-19).

Clin Chem Lab Med 2020 Apr 16. Epub 2020 Apr 16.

Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.

Objectives In December 2019, a novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, China. Laboratory-based diagnostic tests utilized real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat samples. This study evaluated the diagnostic value to analyzing throat and sputum samples in order to improve accuracy and detection efficiency. Read More

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http://dx.doi.org/10.1515/cclm-2020-0187DOI Listing