Search Our Scientific Publications & Authors

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Division of Haematology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.

Guillain-Barré syndrome (GBS) is a rare condition caused by autoimmune damage of peripheral nerves. We describe a case where a man in his 80s presented with subacute, progressive fatigue and weakness. He had received an outpatient work-up for possible haematological malignancy, but eventually presented to the emergency department for worsening weakness. Read More

Transfusion 2022 May 19. Epub 2022 May 19.

University of Chicago, Department of Pathology, 5741 S Maryland Avenue, Chicago, IL.

Background: Hyperhemolysis syndrome (HHS) is a severe delayed hemolytic transfusion reaction seen in sickle cell disease (SCD) patients, characterized by destruction of donor and recipient RBCs. It results in a drop in hemoglobin to below pretransfusion levels and frequently reticulocytopenia.

Case Report: We report a case of a man in his 30s with SCD with a recent hospitalization two weeks prior for COVID-19. Read More

Clin Med (Lond) 2022 May;22(3):210-213

King's College Hospital, London, UK.

Haemolytic anaemia can seem like a complicated topic. The constellation of reticulocytosis, increased lactate dehydrogenase levels, increased unconjugated bilirubin levels and decreased haptoglobin levels should prompt general physicians to consider haemolysis as a differential diagnosis. When further approaching haemolytic anaemia, subdividing patients into those who are 'direct antiglobulin test (DAT) positive' (immune) or 'DAT negative' (non-immune) is a simple and clinically relevant way to start to formulate a cause for the haemolytic anaemia. Read More

J Infect Public Health 2022 Apr 25;15(6):638-642. Epub 2022 Apr 25.

Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University, Bragança Paulista, SP, Brazil. Electronic address:

Rare cases of unusual thrombosis and thrombocytopenia after administration of the ChAdOx1 nCoV-19 vaccine (AstraZeneca) have been reported. The unusual symptoms are called vaccine-induced immune thrombotic thrombocytopenia (VITT). In the present study, a brief background about cases of unusual thrombosis and thrombocytopenia after administration of the ChAdOx1 nCoV-19 was provided. Read More

Immunobiology 2022 Apr 12;227(3):152217. Epub 2022 Apr 12.

Precision Medicine Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China. Electronic address:

Considering the important role of Der f 2 in house dust mites mediating allergic diseases and allergic adverse effects during allergen-specific immunotherapy (AIT), we intend to develop a candidate of desensitization vaccines against Der f 2 without allergenicity. According to the reported immunoglobulin E (IgE)-binding B and T cell epitopes of Der f 2, four candidates of desensitization vaccines against Der f 2 were developed. Recombinant wild-type Der f 2 (rWt-Der f 2) preserved conformational and linear IgE-binding B epitopes. Read More

Klin Lab Diagn 2022 Apr;67(4):234-236

Federal State Budget Institution of Science "Kirov Scientific Research Institute of Hematology and Blood Transfusion of the Federal Medical-Biological Agency".

Timely diagnostics of red blood cells (RBC) antibodies and selection of immunologically compatible donors can prevent the occurrence of hemolytic transfusion reactions in recipients of RBC. The article presents an analysis of a clinical case describing the variability of the antibody screening results and the difficulties of individual selection of donors for a alloimmunized patient with myelodysplastic syndrome. The basic immunohematological principles have been formulated to ensure the safety of transfusions in patients with RBC antibodies. Read More

J Hematol 2022 Apr 12;11(2):66-70. Epub 2022 Apr 12.

Department of Hematology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium.

Delayed hemolytic transfusion reaction (DHTR) is a complication appearing a few days to weeks due to alloimmunization following packed red blood cells (RBCs) transfusion, a pregnancy, or transplantation. Hyperhemolysis syndrome (HS) is a severe form of DHTR defined by a drop of hemoglobin to a level lower than before the transfusion, reflecting a destruction of the patient's own RBCs not presenting the targeted antigen as well as the transfused RBCs. Usually seen in sickle cell disease (SCD) patients, HS remains very rare in patients without a hematologic disorder. Read More

Ceylon Med J 2021 06;66(2):96-99

National Blood Transfusion Service, Ministry of Health, Sri Lanka.

Background And Objectives: Major beta thalassaemia is an inherited haemolytic disease that needs regular blood transfusion as a standard treatment. Blood transfusion is generally safe; however, adverse effects can occur and one of which is red cell alloimmunization that can lead to acute or delayed haemolytic transfusion reactions. This study was designed to estimate the prevalence of red cell alloantibodies in patients with thalassaemia in Sri Lanka. Read More

Transfusion 2022 May 13. Epub 2022 May 13.

Medical Affairs and Innovation, Héma-Québec, Québec city, Canada.

Background: The last economic evaluation of pathogen reduction technology (PRT) in Canada was conducted in 2007. We reassessed the cost-effectiveness of PRT in the province of Québec (which has its own blood supplier) and included an evaluation of the potential impact of emerging pathogens on cost-effectiveness.

Study Design And Methods: Decision analytic Markov models were developed to simulate the costs and quality-adjusted life-years (QALY) associated with PRT as an addition to existing safety measures for plasma and platelet products (except for bacterial culture). Read More

Vox Sang 2022 May 13. Epub 2022 May 13.

Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, People's Republic of China.

Background And Objectives: To advance blood transfusion safety, the Chinese Haemovigilance Network (CHN) was put into operation in 2018. This report describes the development of the CHN and evaluates its role by analysing reported adverse transfusion reactions (ATRs) from 2018 to 2020.

Materials And Methods: All data in this study were obtained from the CHN online reporting platform. Read More

BMJ Case Rep 2022 May 12;15(5). Epub 2022 May 12.

Pulmonary and Critical Care Medicine, Carle Foundation Hospital, Urbana, Illinois, USA

A woman in her 60s developed acute onset headache, blurry vision and encephalopathy a few hours after rituximab infusion, given to treat granulomatosis with polyangiitis. CT scan showed oedema in the posterior circulation area suggesting the diagnosis of posterior reversible encephalopathy syndrome, and an MRI confirmed it. After being treated with aggressive blood pressure control and other supportive measures, her symptoms improved over 3-4 days. Read More

Expert Rev Hematol 2022 May 19:1-11. Epub 2022 May 19.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.

Introduction: Anemia is often present in mostly elderly patients with myelodysplastic syndromes (MDS), and is associated with a poorer outcome. Although red blood cell (RBC) transfusions are the most immediate treatment, waiting for the response to disease-specific therapy, or in case of non-response, the choice of the optimal transfusion regimen is still controversial.

Areas Covered: The main objectives of RBC transfusion are the control of anemia-related symptoms and complications and the improvement of functional status and of health-related quality of life (HRQoL). Read More

Cureus 2022 Apr 9;14(4):e23995. Epub 2022 Apr 9.

Obstetrics/Gynecology, West Suburban Medical Center, Chicago, USA.

Placental abruption during induction of labor in females with intrahepatic cholestasis of pregnancy is not exceptionally common and there are no documented reports of placental prolapse following abruption in the literature. The aim of this study is to discuss the possibility of placental abruption and partial prolapse of a low-lying placenta during a prolonged induction of labor in a female with recurrent intrahepatic cholestasis of pregnancy following a cholecystectomy. We describe a 31-year-old G4P3003 female with recurrent intrahepatic cholestasis of pregnancy, with no family history of the condition and surgical history of cholecystectomy, whose induction of labor at 37+3/7 gestational weeks for intrahepatic cholestasis of pregnancy was complicated by placental abruption and partial prolapse of the low-lying placenta. Read More

Cardiovasc Drugs Ther 2022 May 11. Epub 2022 May 11.

Department of Blood Transfusion, The Second Affiliated Hospital of Hainan Medical College, No. 368 Yehai Avenue, Longhua District, Haikou City, 570105, Hainan Province, China.

Background: Mesenchymal stem cell (MSC)-derived exosomes play significant roles in ameliorating cardiac damage after myocardial ischemia-reperfusion (I/R) injury. Long non-coding RNA alpha-2-macroglobulin antisense RNA 1 (Lnc A2M-AS1) was found that might protect against myocardial I/R. However, whether Lnc A2M-AS1 delivery via MSC-derived exosomes could also regulate myocardial I/R injury remains unknown. Read More

Blood Transfus 2022 Apr 19. Epub 2022 Apr 19.

Department of Haemostasis and Transfusion, Lille University Hospital, Lille, France.

Background: Plasma-derived von Willebrand factor (VWF) (Wilfactin, LFB, France) was developed for prophylaxis and treatment of haemorrhages in both adults and adolescents with von Willebrand disease (VWD). Replacement therapy in paediatric patients is a key element of the clinical trial programme.

Material And Methods: Patients aged <6 years with severe VWD were enrolled in a multinational, open-label study to evaluate the in vivo recovery for Wilfactin, and its efficacy in preventing and treating bleeding episodes and during surgery. Read More

Br J Health Psychol 2022 May 11. Epub 2022 May 11.

School of Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.

Objectives: Repeated blood transfusions are indicated for the management of patients with cancer or blood disorders. Patients' perceptions about transfusions may be associated with decision-making and coping, which has been under-explored in the haematology context. This study therefore aimed to explore haematology transfusion patients' and HCPs' perceptions of blood transfusion, drawing on theory and previously identified themes of transfusion perceptions. Read More

HLA 2022 May 10. Epub 2022 May 10.

Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan Province, China.

The novel HLA-B*48:54 allele was identified in an individual from the Sichuan province of China. This article is protected by copyright. All rights reserved. Read More

Int J Clin Oncol 2022 May 10. Epub 2022 May 10.

Comprehensive Laboratory, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.

Background: The clinical significance of miR-17 in patients with acute myeloid leukemia (AML) remains unknown.

Methods: Real-time quantitative reverse transcription-polymerase chain reaction (qPCR) was performed to detect the miR-17 expression in 115 de novo AML patients, 31 patients at complete remission (CR) time, 8 patients at relapse time and 30 normal controls.

Results: MiR-17 was upregulated in de novo AML compared with normal controls. Read More

Transfus Med 2022 May 9. Epub 2022 May 9.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Recent studies revealed the glucose-6-phosphate dehydrogenase (G-6-PD) deficiency prevalence of 7.7-10% among Thai blood donors. Transfusion of red blood cells (RBCs) from these subjects potentially causes haemolysis in recipients. Read More

Blood Adv 2022 May 9. Epub 2022 May 9.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States.

Heparin, a widely used anticoagulant, carries the risk of an antibody mediated adverse drug reaction, heparin-induced thrombocytopenia (HIT). A subset of heparin-treated patients produces detectable levels of antibodies against complexes of heparin bound to circulating platelet factor 4 (PF4). Using a genome-wide association study (GWAS) approach, we aimed to identify genetic variants associated with anti-PF4/heparin antibodies that account for the variable antibody response seen in HIT. Read More

Neurol India 2022 Mar-Apr;70(2):710-713

Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Therapeutic plasma exchange (TPE) is indicated in the acute presentation of neuromyelitis optica spectrum disorders (NMOSD) as category II indication as per American Society for Apheresis guidelines 2016.

Aim: To assess the efficacy of TPE in symptomatic patients of NMOSD not responding to high dose intravenous steroids.

Patients And Methods: We retrospectively reviewed the record of TPE procedures in NMOSD patients over a period of 3 years (2013-2016). Read More

Front Vet Sci 2022 20;9:830272. Epub 2022 Apr 20.

USFQ & UNC-Chapel Hill Galápagos Science Center (GSC), Av. Alsacio Northia, Isla San Cristobal, Galápagos, Ecuador.

The Galapagos sea lion () is an endemic pinniped to the Galapagos archipelago, and like most wild mammals, is at risk for anemia due to trauma, infectious disease, and poor nutrition. This study evaluated the health status of 26 juvenile Galapagos sea lions on the island of San Cristobal prior to evaluating 100 crossmatch combinations. On evaluation, all but one sea lion had no major systemic abnormalities. Read More

Wiad Lek 2022 ;75(3):624-628

AL-NAHRAIN UNIVERSITY, BAGHDAD, IRAQ.

Objective: The aim: To determine the prevalence of TTV in patients undergoing hemodialysis and to evaluate the possible risk factors.

Patients And Methods: Materials and methods: This study was conducted in 93 patients, attending hemodialysis unit at AL-Imammain AL-Kadhimain Medical City Hospital for a period from November 2020 to March 2021. The demographic and clinical characteristics including age, sex, underling medical condition, hepatitis B and C status and laboratory tests such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline Phosphatase (ALP) and total serum bilirubin (TSB) were obtained from the record of the patients in hemodialysis unit in the hospital. Read More

Equine Vet J 2022 May 6. Epub 2022 May 6.

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: Autologous conditioned serum (ACS) is used to treat osteoarthritis in horses, although its effects are not fully investigated.

Objectives: To investigate the effects of equine serum and conditioned serum on chondrocytes stimulated with interleukin (IL)-1β and cartilage explants with mild osteoarthritis.

Study Design: In vitro experimental study. Read More

Semin Hematol 2022 Apr 7;59(2):108-114. Epub 2022 Mar 7.

Department of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, Universitätsmedizin Greifswald, Greifswald, Germany. Electronic address:

In hundreds of patients worldwide, vaccination against COVID-19 with adenovirus vector vaccines (ChAdOx1 nCoV-19; Ad26.COV2.S) triggered platelet-activating anti-platelet factor 4 (PF4) antibodies inducing vaccine-induced immune thrombotic thrombocytopenia (VITT). Read More

J Feline Med Surg 2022 May 5:1098612X221094502. Epub 2022 May 5.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada.

Objectives: The aim of this study was to characterize anti-feline erythrocyte antigen (FEA) 1 alloantibodies following sensitization of FEA 1-negative cats, including their rate of appearance, agglutination titer over time and immunoglobulin class. A secondary aim was to obtain polyclonal anti-FEA 1 alloantibodies to increase the availability of FEA 1 blood typing. We also describe a case study documenting an acute hemolytic transfusion reaction in a transfusion-naive FEA 1-negative feline patient that received FEA 1-positive blood. Read More

Transfusion 2022 May 5. Epub 2022 May 5.

Stanford Blood Center, Palo Alto, California, USA.

Background: Blood centers have a dual mission to protect donors and patients; donor safety is paramount to maintaining an adequate blood supply. Elucidating donor factors associated with adverse reactions (AR) is critical to this mission.

Study Design/methods: A retrospective cohort analysis of whole blood donors from 2003 to 2020 was conducted at a single blood center in northern California. Read More

Transfus Med Rev 2022 Apr 14;36(2):77-81. Epub 2022 Apr 14.

French National Agency for Medicines and Health Products Safety (ANSM), Saint Denis, France.

Few data are currently available on hypersensitivity transfusion reactions (HTRs) after exposure to fresh frozen plasma (FFP). Between 2000 and 2018, three different FFP production strategies have been used in France, leading to the concomitant use of different types of FFP. The objective of this study was to describe the rate of FFP-related HTRs and to assess the relative risk of each type of FFP. Read More

Front Nutr 2022 14;9:849314. Epub 2022 Apr 14.

Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Background: The COVID-19 pandemic has been consistently associated with unhealthy lifestyle behaviors and dietary practices. This study aimed to assess the dietary and lifestyle behaviors of adults after COVID-19 vaccine availability and their attitude toward the vaccine in selected Arab countries.

Methods: A cross-sectional survey-based study was conducted between October 2021 and December 2021 using Google Forms ( = 2259). Read More