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Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):438-441

Department of Blood Transfusion, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

To reduce the occurrence of adverse events of clinical blood use by analyzing the clinical adverse events of blood use except for the adverse reactions of blood transfusion. A retrospective analysis was performed on 294 cases of adverse events of clinical blood use other than adverse blood transfusion reactions in Shijitan hospital from January 2014 to December 2017, and a statistical analysis was made on the types of adverse events of clinical blood use, blood transfusion related departments, and internal and surgical blood use. The incidence of adverse events of clinical blood use was 10. Read More

Transfusion 2019 Feb 19. Epub 2019 Feb 19.

Department of Advanced Cancer Immunotherapy, Fukushima Medical University, Fukushima, Japan.

Background: Weak D-type RBCs have fewer D epitopes, but it remains unclear whether individuals with certain types of weak D produce alloanti-D directed at D epitopes absent from the RBCs, and whether it is an alloantibody or an autoantibody. We report the first case of a patient with a weak D Type 15 who produced autoantibodies mimicking alloanti-D.

Case Report: A 52-year-old Japanese male with weak D developed anti-D 3 months after transfusion of D-negative and -positive RBCs, and the antibody persisted for 24 months with a consistently negative direct antiglobulin test. Read More

Vox Sang 2019 Feb 19. Epub 2019 Feb 19.

National Medical Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Background: Transmission of pathogens through blood transfusion is still of great concern to clinicians, patients and blood providers. Pathogen reduction technologies (PRT) have been successfully applied for the treatment of labile blood components, such as plasma, platelets and whole blood (WB), which are now used in routine in many countries. We report the clinical evaluation of suspension of red blood cells (RBC-S) derived from the WB treated with riboflavin and UV light (RF+UV). Read More

Iran J Otorhinolaryngol 2019 Jan;31(102):1-9

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Allergic Rhinitis (AR) is a common inflammatory disease of the nasal mucosa. The CD14 is a receptor for lipopolysaccharide and inhaled endotoxin which can stimulate the production of interleukins by antigen presenting cells. Accordingly, CD14 plays an important role in allergic and atopic diseases, which can be one of the etiological factors for allergic diseases. Read More

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Gastroenterology, Karolinska University Hospital, 17177 Stockholm, Sweden.

Exclusive Enteral Nutrition (EEN) is the first-line treatment in children with Crohn's disease (CD) for induction of remission. However, the mode of action remains conjectural. The aim of this study was to investigate whether the effect of EEN is paralleled by changes in the mucosal cytokine profiles (MCP). Read More

Indian J Med Res 2018 Dec;148(6):713-720

Department of Transfusion Medicine, ICMR-National Institute of Immunohaematology, KEM Hospital Campus, Mumbai, India.

Background & Objectives: In multitransfused thalassaemic patients, haemagglutination fails to phenotype the patient's blood group antigens due to the presence of donor-derived erythrocytes. DNA-based methods can overcome the limitations of haemagglutination and can be used to determine the correct antigen profile of these patients. This will facilitate the procurement of antigen-matched blood for transfusion to multitransfused patients. Read More

BMC Pediatr 2019 Feb 18;19(1):61. Epub 2019 Feb 18.

Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.

Background: Beta thalassemia (β-thal) is an inherited hemoglobin disorder characterized by reduced synthesis of the hemoglobin that results in microcytic hypochromic anemia. β-Thalassemia intermedia (TI) is a clinical term of intermediate gravity between the carrier state and β-thalassemia major (β -TM).

Case Presentation: We describe a 12-year-old male proband originating from Al-Quneitra province - southwest Syria. Read More

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):322-328

Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Hematopoietic stem cell transplantation (HSCT) is a useful treatment. In contrast to solid organ transplantations, the use of ABO blood group mismatch is acceptable in HSCT. Immediate or late hemolytic reactions, pure red cell aplasia, delayed red blood cell recovery, and graft-versus -host disease are the results of this situation. Read More

Hum Immunol 2019 Feb 26;80(2):97-102. Epub 2018 Oct 26.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

Virus-specific T cells have been shown to cross-react with allogeneic HLA (allo-HLA) at a clonal level. However, the impact of a single virus on the allorepertoire has never been investigated at the polyclonal level. We made an inventory of the incidence and specificity of allo-HLA-cross-reactive-virus-specific CD8 T cells in 24 healthy individuals. Read More

J Cell Biochem 2019 Feb 16. Epub 2019 Feb 16.

Department of Biotechnology, Molecular and Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Colorectal cancer (CRC) is known as the third most common malignancies among men and women and is also the second leading cause of cancer-related deaths worldwide. It has been indicated that a variety of risk factors are involved in the pathogenesis of CRC. Spalt-like transcription factor 4 (SALL4) is known as a transcription factor that plays an important role in the proliferation of cancerous cells. Read More

Transfusion 2019 Feb 15. Epub 2019 Feb 15.

Division of Hematology and Oncology, University of Florida, Gainesville, Florida.

Background: Delayed hemolytic transfusion reaction (DHTR) with hyperhemolysis is a potentially fatal complication resulting from alloimmunization that can cause severe hemolysis of both transfused and intrinsic red blood cells (RBCs). Patients with sickle cell disease often receive multiple RBC units during their lifetime and thus are likely to develop alloantibodies that increase the risk for DHTR. Treatment to decrease hemolysis includes intravenous immunoglobulin (IVIG), steroids, eculizumab, rituximab, and plasmapheresis in addition to erythropoietin (EPO), intravenous (IV) iron, vitamin B12, and folate to support erythropoiesis. Read More

Minerva Anestesiol 2019 Feb 13. Epub 2019 Feb 13.

S.C. di Anestesia e Rianimazione, Dipartimento di Scienze Mediche e Chirurgiche, Università di Foggia, Foggia, Italy -

Patient blood management is currently defined as the application of evidence based medical and surgical concepts designed to maintain hemoglobin (Hb), optimize hemostasis and minimize blood loss to improve patient outcome. Blood management focus on the perioperative management of patients undergoing surgery or other invasive procedures in which significant blood loss occurs or is expected. Preventive strategies are emphasized to identify and manage anemia, reduce iatrogenic blood losses, optimize hemostasis (e. Read More

Transfusion 2019 Feb 13. Epub 2019 Feb 13.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: Human serum albumin (HSA) is a commonly used colloid for volume expansion and albumin replacement and during plasmapheresis. Colloids are an uncommon cause of anaphylaxis, and cases of hypersensitivity reactions to HSA are extremely rare.

Case Report: A 10-year-old boy with chronic inflammatory demyelinating polyneuropathy was treated with plasmapheresis, with albumin as the replacement fluid. Read More

Trials 2019 Feb 12;20(1):125. Epub 2019 Feb 12.

Department of Anesthesiology, Peking Union Medical College Hospital, No.1 Shuai Fu Yuan, Wang Fu Jing Street, Beijing, 100730, People's Republic of China.

Background: Tranexamic acid (TXA) has been routinely delivered in multisegmental spinal decompression and bone graft fusion surgeries with satisfactory outcomes in minimizing gross blood loss and transfusion demands. However, concerns remain that intravenously delivered TXA (ivTXA) may increase risks of postoperative convulsive seizures and systemic thrombogenicity. Topical use of TXA (tTXA), being more targeted to the surgical bleeding site while minimizing patient systemic exposure to ivTXA, has been successfully applied to attenuate blood losses and transfusion requirements in hip and knee arthroplasty. Read More

Blood Transfus 2018 Dec 13:1-10. Epub 2018 Dec 13.

Department of Clinical Science, University of Bergen, Norway.

Background: In thrombocytopenic patients better assessment of bleeding risk than that provided by platelet count alone is required. Multiplate aggregometry and thromboelastography (TEG) could be used, but information on their role in such patients is limited. The primary aim of this study was to investigate the feasibility of Multiplate analyses in patients with haematological malignancies. Read More

Oncol Rep 2019 Mar 23;41(3):2009-2019. Epub 2019 Jan 23.

Department of Biochemistry and Molecular Biology, The Key Laboratory of Neurobiology and Vascular Biology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.

Accumulating evidence has implicated that the activation of signal transducer and activator of transcription 3 (STAT3) contributes to the progression of liver cancer by affecting the expression of proliferation‑associated genes. A previous study reported that elevated levels of 17β‑hydroxysteroid dehydrogenase 4 (HSD17B4) are observed in patients with liver cancer. The current study investigated how upregulated HSD17B4 expression promoted the expression of proliferation‑associated genes in rats with liver cancer. Read More

Int Immunopharmacol 2019 Feb 8;69:257-262. Epub 2019 Feb 8.

Gansu Key Laboratory of Functional Genomics and Molecular Diagnosis, East Road no. 110 Nanhe Yantan, Chengguan District, Lanzhou, Gansu Province, PR China; Laboratory of Precision Medicine and Translational Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, Jiangsu Province, PR China.

Skin lesions are typical clinical manifestations of systemic lupus erythematosus (SLE) and the biomarker for predicting SLE skin injury is not clear. We conducted a hospital-based case-control study with aim to explore the predictive value of the ratio of aryl hydrocarbon receptor (AhR) in T helper 17 (Th17) cells to AhR in regulatory T (Treg) cells (AhR ratio) in SLE skin lesions. The clinical and laboratory data were obtained from their medical records, and the AhR relative expression levels were evaluated by reverse transcription-quantitative polymerase chain reaction. Read More

Sci Rep 2019 Feb 11;9(1):1740. Epub 2019 Feb 11.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Korea.

Blood transfusions temporarily improve the physical state of the patient but exert widespread effects on immune and non-immune systems. Perioperative allogeneic blood transfusions (ABT) are associated with various risks, including coagulopathy, incompatibility, transmission of infectious agents, and allergic reactions. Nevertheless, little is known about the global metabolic alterations that reflect the possible reactions of blood transfusions. Read More

Transfusion 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Whole blood (WB) is an appealing alternative to component-based transfusion in patients with significant bleeding. Historically, WB was transfused less than 48 hours after collection and was not leukoreduced (LR). However, LR components are now standard in many hospitals and LR WB is desirable. Read More

J Paediatr Child Health 2019 Feb 8. Epub 2019 Feb 8.

Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

Anaemia of prematurity will affect 90% of all very preterm infants, resulting in at least one red blood cell (RBC) transfusion. A significant proportion of preterm infants require multiple transfusions over the course of hospital admission. Growing evidence supports an association between transfusion exposure and adverse neonatal outcomes. Read More

Transfusion 2019 Feb 8. Epub 2019 Feb 8.

Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.

Background: Cryopreservation in dimethyl sulfoxide and storage at -80 °C extends the shelf life of platelets to at least 2 years, allowing greater availability in rural and military areas. While cryopreserved platelets (CPPs) have been extensively characterized for coagulation and thrombin generation, reports on the mechanism of adverse reactions to CPPs transfusion are scarce. Here, we tested the hypothesis that CPPs facilitate phagocytosis by Kupffer cells and subsequently promote the inflammatory response in Kupffer cells. Read More

Vox Sang 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.

Background And Objectives: Passive transfusion reaction reporting systems fail to capture a significant number of reactions, and no data exist on provider reporting trends. The aim of this study was to describe transfusion reaction reporting patterns by adult and paediatric providers.

Materials And Methods: This is a multihospital study on transfusion reaction reporting over a 7-year period. Read More

Transfus Med 2019 Feb 6. Epub 2019 Feb 6.

Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Review US Food & Drug Administration, Silver Spring, Maryland, USA.

The International Haemovigilance Network (IHN) defines haemovigilance as 'a set of surveillance procedures covering the whole transfusion chain (from the collection of blood and its components to the follow-up of recipients), intended to collect and assess information on unexpected or undesirable effects resulting from the therapeutic use of labile blood products, and to prevent their occurrence or recurrence'. IHN, the International Society of Blood Transfusion and World Health Organisation work together to support both developing and established haemovigilance systems. Haemovigilance systems provide valuable data on a range of adverse events related to blood donation and clinical transfusion, from donor syncopal events to transfusion-transmitted infections, immunological complications and the impact of human errors. Read More

Cardiovasc Hematol Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Cellular and Molecular Research Center, Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Science, Tehran. Iran.

Background: About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α) and FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA.

Methods: We divided 39 patients with severe HA in two groups of cases (n: 19) and control (n: 20). Read More

Transfusion 2019 Feb 10;59(2):458-462. Epub 2018 Nov 10.

Department of Communicable Diseases, Interactive Research School for Health Affairs, Bharati Vidyapeeth (Deemed To Be University), Pune, India.

Background: Dengue, a mosquito-borne viral disease, is endemic in >125 countries worldwide. The threat of blood-borne transmission of dengue virus (DENV) has been documented.

Study Design And Methods: This study was conducted to assess the potential magnitude of transfusion-associated dengue, by determination of DENV seromarkers in blood donations from Pune, India, during two dengue seasons (2016 and 2017). Read More

Rev Med Chil 2018 Nov;146(11):1347-1350

Servicio de Medicina, Santiago, Chile.

Sickle cell anemia was a rare disease in Chile, especially in adults, however the recent immigration wave from Haiti is changing this scenario. We report a 29 year old black female from Haiti with a non-disclosed history of sickle cell anemia. She was transfused with two units of red blood cells, found unconscious and with jaundice five days later and admitted to the hospital. Read More

Oncoimmunology 2019 11;8(2):e1528411. Epub 2018 Nov 11.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.

Cytokine-induced killer (CIK) cells are demonstrated to possess potent cytolytic effect against ovarian cancer cells and . However, the clinical efficacy of maintenance therapy of CIK cells in patients with epithelial ovarian cancer (EOC) after first-line treatment remains unclear. This retrospective study included 646 cases of postoperative EOC patients, 72 of which received chemotherapy and sequential immunotherapy (CIT group), and 574 of which received only chemotherapy (Control group). Read More

Trends Mol Med 2019 Feb 30;25(2):149-163. Epub 2019 Jan 30.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany; Department of Nephrology and Internal Intensive Care Medicine, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany; Berlin Center for Advanced Therapies (BECAT), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany; Equal contribution senior authorship.

Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Read More

FASEB J 2019 Jan 31:fj201801853RR. Epub 2019 Jan 31.

Department of Biochemistry, Medical Faculty, Justus Liebig University, Giessen, Germany.

Tissue-resident mast cells (MCs) are well known for their role in inflammatory responses and allergic and anaphylactic reactions, but they also contribute to processes of arterial remodeling. Although ribosomes and cytosolic RNAs are located around secretory granules in mature MCs, their functional role in MC responses remains unexplored. Previous studies by our group characterized extracellular RNA (eRNA) as an inflammatory and pathogenetic factor in vitro and in vivo. Read More

Transfusion 2019 Jan 31. Epub 2019 Jan 31.

Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, AUMC, Amsterdam, The Netherlands.

Background: Alloimmunization against the high-frequency Vel blood group antigen may result in transfusion reactions or hemolytic disease of fetus and newborn. Patients with anti-Vel alloantibodies require Vel-negative blood but Vel-negative individuals are rare (1:4000). Identification of Vel-negative donors ensures availability of Vel-negative blood; however, accurate Vel blood group typing is difficult due to variable Vel antigen expression and limited availability of anti-Vel typing sera. Read More

Transfusion 2019 Jan 31. Epub 2019 Jan 31.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Background: Hepatitis E virus (HEV) can inapparently infect blood donors. To assess transfusion transmission of HEV in the United States, which has not been documented, a donor-recipient repository was evaluated.

Study Design And Methods: To identify donations that contained HEV RNA and were linked to patient-recipients with antibody evidence of HEV exposure, we assayed samples from the Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient repository that represents 13,201 linked donations and 3384 transfused patients. Read More

Int J Mol Sci 2019 Jan 28;20(3). Epub 2019 Jan 28.

Department of Transplantation Medicine, Nephrology, Internal Diseases, T. Orłowski Institute of Transplantation Medical University of Warsaw, 59 Nowogrodzka Street, 02-006 Warsaw, Poland.

Infection with cytomegalovirus (CMV) remains a major problem in kidney transplant recipients, resulting in serious infectious complications and occasionally mortality. Accumulating evidence indicates that natural killer cell immunoglobulin-like receptors (KIRs) and their ligands affect the susceptibility to various diseases, including viral infections (e.g. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):176-179

Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

ABO incompatibility and other alloantibodies have emerged as a significant cause of hemolytic disease of fetus and newborn (HDFN), leading to neonatal morbidity and mortality. We report three cases of severe ABO-HDFN where blood exchange transfusions (ETs) were required in neonates with hyperbilirubinemia. Blood grouping (ABO/RhD) was performed using conventional tube technique. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):169-172

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal Academy of Higher Educations, Manipal, Karnataka, India.

Detection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents and human resources. We report one such nuisance antibody detected in an antenatal female that showed pan reaction with antibody screening and identification panel red cells including auto control but was compatible with group-specific donor units. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):141-145

Department of Transfusion Medicine, Max Super-speciality Hospital, Shalimar Bagh, New Delhi, India.

Background: Auditing and education are the tools for improvement in the transfusion practices. Clinicians are not providing patient's demographic data and medical history to the blood bank that required transfusion. This missing information in blood request forms can lead to transfusion reactions to the patient. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):136-140

Department of Transfusion Medicine, Rotary Bangalore TTK Blood Bank, Bangalore Medical Services Trust, Bengaluru, Karnataka, India.

Background: Platelet additive solutions (PAS) are crystalloid nutrient media used in place of plasma for platelet storage. They replace 60%-70% of plasma in platelet components, so the amount of storage plasma can be decreased. Platelets in PAS have lower risk for allergic transfusion reactions with equivalent clinical efficacy for controlling bleeding. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):112-116

ICMR Virus Unit, I.D. and B.G. Hospital, Kolkata, West Bengal, India.

Introduction: One of the most common blood-borne transfusion-transmitted diseases is hepatitis C. Patients with a history of multiple blood transfusions are significantly at a greater risk of infection by contaminated blood and blood products. Beta thalassemia major is one such condition where repeated blood transfusions are required for patient management. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):99-104

Department of Transfusion Medicine, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India.

Background And Aim: Patients with warm autoimmune hemolytic anemia (AIHA) may carry immunoglobulin (Ig) M antibodies that react at room temperature and are nonpathological, but few may have cold agglutinins that react at or above 30°C and are referred to as "mixed" AIHA (MAIHA). Here, we present our experience on characterizing MAIHA both clinically and serologically.

Materials And Methods: Out of 134 AIHA patients, 13 diagnosed as MAIHA were subjected to detailed immunohematological characterization. Read More

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics & Gynecology, Indiana University School of Medicine, 550N. University Boulevard, UH 2440, Indianapolis, IN, 46202, USA.

Objective: To assess the effect of intravenous versus oral iron on hematologic indices and clinical outcomes for iron-deficiency anemia (IDA) in pregnancy.

Study Design: Searches in Ovid Medline, Embase, SCOPUS, Cochrane Database, and ClinicalTrials.gov identified randomized-controlled trials comparing intravenous to oral iron for treating IDA in pregnancy. Read More

Clin Cancer Res 2019 Jan 28. Epub 2019 Jan 28.

Office of Oncology Drug Products, United States Food and Drug Administration.

The Food and Drug Administration approved ivosidenib (Tibsovo; Agios, Cambridge, MA), a small molecule inhibitor of isocitrate dehydrogenase (IDH)1 on July 20, 2018, for treatment of adults with relapsed or refractory acute myeloid leukemia (R/R AML) with susceptible IDH1 mutation as detected by an FDA-approved test. The efficacy of ivosidenib was established based on complete remission (CR) + CR with partial hematologic recovery (CRh) rate, duration of CR+CRh, and conversion from transfusion-dependence (TD) to transfusion-independence (TI) in the single-arm Study AG120-C-001. With median follow-up 8. Read More

J Matern Fetal Neonatal Med 2019 Jan 27:1-14. Epub 2019 Jan 27.

b Department of Neurology [Medicine] , Duke University , Durham , NC , USA.

Background: Though blood transfusions are the common procedures in pediatric patients, transfusion reactions are rare in children. Though in adults, uncross-matched ABO group-specific blood is used in emergencies, there are no such reports in neonates and children. There are stray case reports about transfusing maternal blood for her baby and maternal blood is de facto compatible regardless of an ABO mismatch Objective: Confirming our previous hypothesis that maternal blood is compatible with her baby's blood; and maternal blood can be used for transfusion in her newborn baby irrespective of ABO match/ mismatch. Read More

Mol Genet Metab 2018 Dec 27. Epub 2018 Dec 27.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America. Electronic address:

Congenital erythropoietic porphyria (CEP) is a rare autosomal recessive disorder characterized by photosensitivity and by hematologic abnormalities in affected individuals. CEP is caused by mutations in the uroporphyrinogen synthase (UROS) gene. In three reported cases, CEP has been associated with a specific X-linked GATA1 mutation. Read More

Adv Hematol 2018 20;2018:7938130. Epub 2018 Dec 20.

CHU UCL Namur asbl, 15 place L. Godin, 5000 Namur, Belgium.

Traceability is an essential tool for haemovigilance and transfusion safety. In Burkina Faso, the implementation of haemovigilance has been achieved as part of a pilot project from 2005 to 2009. Our study aims to evaluate the traceability of blood transfusions and reporting of adverse reactions over the 6-year postpilot phase. Read More

Transfus Apher Sci 2019 Jan 6. Epub 2019 Jan 6.

Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan. Electronic address:

Plasma removal by washing platelet concentrates (PCs) is effective in preventing adverse reactions to PC transfusions. The Japanese Red Cross Society (JRCS) started releasing washed PCs (WPCs) as a commercially approved blood product in September 2016. This retrospective multicenter study investigated the change in the number of transfused WPCs and the impact on the incidence of adverse reactions to PCs before and after the release. Read More

Int J Infect Dis 2019 Jan 18. Epub 2019 Jan 18.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Objectives: This study was performed to determine the presence of West Nile virus (WNV) in mosquito specimens and human blood donors from Pakistan.

Methods: 4,500 mosquito specimens were collected using CO-baited traps from five selected districts of Punjab province, Pakistan. Mosquito were taxonomically identified using standard morphological keys resulting in 166 pools. Read More

Oncol Lett 2019 Jan 19;17(1):195-200. Epub 2018 Oct 19.

Department of Blood Transfusion, The Second Hospital of Shandong University, Jinan, Shandong 250000, P.R. China.

Regulatory effect of puerarin on bladder cancer T24-cell apoptosis and its possible mechanism were investigated. The experimental subjects were divided into the experimental group, the control group and the blank control group, and the cell inhibition rates after treatment were detected, respectively. Then, subjects were further divided into the control group, the puerarin group (treated with puerarin), the agonist group [treated with silent information regulator 1 (SIRT1) agonist SRT1720], the inhibitor group (treated with SIRT1 inhibitor EX527) and the combination group (treated with SRT1720, and then with puerarin). Read More

J Blood Med 2019 3;10:37-46. Epub 2019 Jan 3.

Department of Biomedical Engineering, University of Houston, Houston, TX 77204-5060, USA,

Millions of blood components including red blood cells, platelets, and granulocytes are transfused each year in the United States. The transfusion of these blood products may be associated with adverse clinical outcomes in some patients due to residual proteins and other contaminants that accumulate in blood units during processing and storage. Blood products are, therefore, often washed in normal saline or other media to remove the contaminants and improve the quality of blood cells before transfusion. Read More

Malar J 2019 Jan 15;18(1). Epub 2019 Jan 15.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Malaria can be transmitted by blood transfusion from human to human and it is responsible for the majority of transfusion-transmitted infectious diseases worldwide. In sub-Saharan Africa, it had been estimated that almost a quarter of blood donations contain malaria parasites. Since rapid diagnostic tests and thick blood smear microscopy lack sensitivity for low density parasitaemia, particularly in asymptomatic adults, the most reliable method to assess the problem of transfusion-transmitted malaria are nucleic acid-based molecular approaches such as quantitative polymerase chain reaction. Read More

Gene 2019 Apr 12;692:102-112. Epub 2019 Jan 12.

Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences (IBG UFRC RAS), Pr. Oktybry 71, Ufa 450054, Russian Federation; Bashkir State Medical University, Department of Biology, Department of Internal Diseases, Lenina Str, 3, Ufa 450008, Russian Federation.

Background And Objective: Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease of the respiratory system affecting primarily distal respiratory pathways and lung parenchyma. This work was designed as a case-control study aimed at investigating the association of the NRF2/KEAP1 signaling system, and antioxidant defense gene polymorphisms with COPD in population from Russia.

Methods: Ten SNPs: NFE2L2 (rs35652124), KEAP1 (rs1048290), MPO (rs2333227), PRNP (rs1799990), PTGR1 (rs2273788), HSPA1A (rs1008438), TXNRD2 (rs1139793), GSR (rs1002149), SIRT2 (rs10410544), and PTGS1 (rs1330344) were genotyped by the real-time polymerase chain reaction (TaqMan assays) in a case-control study (425 COPD patients and 457 controls, from the same region of Russia, representatives of Tatar population). Read More

Clin Transplant 2019 Jan 12:e13478. Epub 2019 Jan 12.

Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Introduction: Thromboelastography (TEG) is gaining increasing acceptance in liver transplantation (LT) with conventional coagulation tests (CCTs) such as prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (ATIII), platelet count (PLT), and fibrinogen concentration. The purpose of this study was to evaluate the clinical utility of TEG in LT and investigate the correlation between TEG and CCT values during each phase of LT.

Materials And Methods: Medical records of patients who underwent deceased donor LT at a single, university hospital between October 2010 and July 2015 were retrospectively reviewed. Read More