5,258 results match your criteria Trachoma

To eliminate trachoma: Azithromycin mass drug administration coverage and associated factors among adults in Goro district, Southeast Ethiopia.

PLoS Negl Trop Dis 2022 Jun 27;16(6):e0010169. Epub 2022 Jun 27.

Department of Public Health, School of Health Sciences, Madda Walabu University, Goba, Ethiopia.

Background: Globally, although effective prevention strategies and treatment are available, trachoma remains the major cause of infectious loss of sight. Trachoma is a predominant neglected disease in Ethiopia, and there is a 40.4% prevalence of active trachoma in the Goro district, Southeast Ethiopia. Read More

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Evaluation of the efficacy of insecticide-treated scarves to protect children from the trachoma vector (Diptera: Muscidae): A phase II randomised controlled trial in Oromia, Ethiopia.

EClinicalMedicine 2022 Jul 8;49:101487. Epub 2022 Jun 8.

Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: The eye-seeking fly can act as a vector for ocular , causing trachoma, yet there has been very little research on control measures. We investigated whether insect repellent products, specifically insecticide-treated clothing, could provide personal protection to the user from eye-seeking flies.

Methods: We first conducted a series of phase I laboratory studies to inform our choice of field intervention. Read More

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Modified Fluoroquinolones as Antimicrobial Compounds Targeting .

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

Université Paris Cité, CNRS, ITODYS, F-75013 Paris, France.

causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. Read More

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Prevalence of active trachoma and its associated factors among 1-9 years of age children from model and non-model kebeles in Dangila district, northwest Ethiopia.

PLoS One 2022 15;17(6):e0268441. Epub 2022 Jun 15.

Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Trachoma is the leading infectious disease that leads to blindness worldwide, especially in developing countries. Though Ethiopia had targeted a trachoma elimination program by 2020, the problem worsens, particularly in the Amhara Region. Even though sustained intervention measures are undertaken across the region, it is unclear why trachoma is still a significant public health problem. Read More

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Nat Rev Dis Primers 2022 05 26;8(1):33. Epub 2022 May 26.

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Nat Rev Dis Primers 2022 05 26;8(1):32. Epub 2022 May 26.

Programme National de la Santé Oculaire, Ministère de la Santé, Bamako, Mali.

Trachoma is a neglected tropical disease caused by infection with conjunctival strains of Chlamydia trachomatis. It can result in blindness. Pathophysiologically, trachoma is a disease complex composed of two linked chronic processes: a recurrent, generally subclinical infectious-inflammatory disease that mostly affects children, and a non-communicable, cicatricial and, owing to trichiasis, eventually blinding disease that supervenes in some individuals later in life. Read More

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Fluorescent Biosensor Based on Hairpin DNA Stabilized Copper Nanoclusters for Chlamydia trachomatis Detection.

J Fluoresc 2022 May 25. Epub 2022 May 25.

Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.

Chlamydia trachomatis (C. trachomatis) is a kind of intracellular parasitic microorganism, which can causes many diseases such as trachoma. In this strategy, a specific hairpin DNA with the probe loop as specific regions to recognize C. Read More

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Neglected tropical diseases in Australia: a narrative review.

Med J Aust 2022 Jun 12;216(10):532-538. Epub 2022 May 12.

Australian National University, Canberra, ACT.

•Neglected tropical diseases (NTDs) represent a threat to the health, wellbeing and economic prosperity of billions of people worldwide, often causing serious disease or death. •Commonly considered diseases of low and middle-income nations, the presence of NTDs in high income countries such as Australia is often overlooked. •Seven of the 20 recognised NTDs are endemic in Australia: scabies, soil-transmitted helminths and strongyloidiasis, echinococcosis, Buruli ulcer, leprosy, trachoma, and snakebite envenoming. Read More

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Seasonal variation in water use for hygiene in Oromia, Ethiopia, and its implications for trachoma control: An intensive observational study.

PLoS Negl Trop Dis 2022 05 13;16(5):e0010424. Epub 2022 May 13.

Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.

If facial hygiene practices vary seasonally this could have important implications for the design of interventions for trachoma control. This observational study was conducted to explore seasonal variation in hygiene behaviours in 9 households with at least one child aged 1-9 years-of-age in the West Arsi zone in rural Oromia, Ethiopia. Sixty-one household members were observed intensively over two days in the dry season (January), the rainy season (July) and during the harvest period (October) in 2018. Read More

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Prevalence of active trachoma and associated factors among school age children in Debre Tabor Town, Northwest Ethiopia, 2019: a community based cross-sectional study.

Ital J Pediatr 2022 May 3;48(1):61. Epub 2022 May 3.

Department of Environmental Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Trachoma is an infectious eye disease caused by Chlamydial trachomatis. It is a major health problem in poor nations, notably in Sub-Saharan Africa. Despite the severity of the problem, there was a scarcity of data on trachoma prevalence and associated factors among school-aged children in Debre Tabor town following SAFE and MDA. Read More

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Interventions for Neglected Tropical Diseases Among Children and Adolescents: A Meta-analysis.

Pediatrics 2022 05;149(Suppl 5)

Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan.

Background: Neglected tropical diseases (NTDs) are a group of communicable diseases affecting the poorest populations around the world.

Objective: To assess the effectiveness of interventions, including mass drug administration (MDA), water, sanitation, and hygiene (WASH), vector control, health education, and micronutrients supplementation, for NTDs among children and adolescents.

Methods: We conducted a literature search on the Cochrane Controlled Trials Register, Medline, and other databases until December 2020. Read More

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Prevalence of Trachoma from 66 Impact Surveys in 52 Woredas of Southern Nations, Nationalities and Peoples' and Sidama Regions of Ethiopia, 2017-2019.

Ophthalmic Epidemiol 2022 Apr 27:1-10. Epub 2022 Apr 27.

Orbis International Ethiopia, Orbis International Ethiopia, Addis Ababa, Ethiopia.

Purpose: Trachoma is endemic in Southern Nations, Nationalities and Peoples' (SNNP) and Sidama regions of Ethiopia. We aimed to measure the prevalence of trachomatous inflammation - follicular (TF) among children aged 1 - 9 years and the prevalence of trachomatous trichiasis (TT) unknown to the health system among people aged ≥15 years following interventions for trachoma in 52 woredas of SNNP and Sidama regions.

Methods: From 2017 - 2019, 66 two-stage cluster sampling cross-sectional population-based surveys were carried out in 52 woredas (third-level administrative divisions) using a standardized World Health Organization-recommended survey methodology. Read More

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: quest for an eye-opening vaccine breakthrough.

Expert Rev Vaccines 2022 Jun 26;21(6):771-781. Epub 2022 Apr 26.

Department of Immunology, Institute for Health and Sport, Victoria University, Melbourne VIC Australia.

Introduction: commonly referred to as chlamydia (a bacterium), is a common sexually transmitted infection, and if attended to early, it can be treatable. However, if left untreated it can lead to serious consequences. infects both females and males although its occurrence in females is more common, and it can spread to the eyes causing disease and in some case blindness. Read More

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A national survey integrating clinical, laboratory, and WASH data to determine the typology of trachoma in Nauru.

PLoS Negl Trop Dis 2022 04 19;16(4):e0010275. Epub 2022 Apr 19.

The Kirby Institute, University of New South Wales, Sydney, Australia.

Background: The epidemiology of trachoma in several Pacific Islands differs from other endemic settings, in that there is a high prevalence of clinical signs of trachoma, particularly trachomatous inflammation-follicular (TF), but few cases of trichiasis and limited evidence of ocular chlamydial infection. This so-called "Pacific enigma" has led to uncertainty regarding the appropriate public health response. In 2019 alongside Nauru's national trachoma population survey, we performed bacteriological and serological assessments of children to better understand the typology of trachoma and to determine whether there is a need for trachoma interventions. Read More

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Towards a Deeper Understanding of Pathogenetic Mechanisms: Editorial to the Special Issue " Pathogenicity and Disease".

Int J Mol Sci 2022 Apr 1;23(7). Epub 2022 Apr 1.

Department of Public Health and Infectious Diseases, University of Rome "Sapienza", P.le Aldo Moro 5, 00185 Rome, Italy.

, an obligate intracellular Gram-negative bacterium, is characterized by a wide range of different serotypes responsible for several local or systemic human diseases, including genital tract manifestations (D-K), trachoma (A-C), and lymphogranuloma venereum (L1-3) [... Read More

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Community-level trachoma ecological associations and the use of geospatial analysis methods: A systematic review.

PLoS Negl Trop Dis 2022 04 8;16(4):e0010272. Epub 2022 Apr 8.

London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Trachoma is targeted for global elimination as a public health problem by 2030. Understanding individual, household, or community-associated factors that may lead to continued transmission or risk of recrudescence in areas where elimination has previously been achieved, is essential in reaching and maintaining trachoma elimination. We aimed to identify climatic, demographic, environmental, infrastructural, and socioeconomic factors associated in the literature with trachoma at community-level and assess the strength of their association with trachoma. Read More

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Expression and structure of the Chlamydia trachomatis DksA ortholog.

Pathog Dis 2022 05;80(1)

Paul G. Allen School for Global Health, Washington State University, Pullman, WA 99164, USA.

Chlamydia trachomatis is a bacterial obligate intracellular parasite and a significant cause of human disease, including sexually transmitted infections and trachoma. The bacterial RNA polymerase-binding protein DksA is a transcription factor integral to the multicomponent bacterial stress response pathway known as the stringent response. The genome of C. Read More

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Characteristics and perspectives of patients with postoperative trichiasis in Hadiya Zone, Ethiopia.

Int Health 2022 04;14(Suppl 1):i49-i56

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Postoperative trachomatous trichiasis (PTT) is a challenge for trichiasis surgery programs. Little is known about PTT patients' perceptions regarding outcomes and future disease management. This study aimed to understand the characteristics of PTT patients, how they managed trichiasis and their perceptions of prior surgeries and future surgery uptake. Read More

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Productivity, efficiency and gender equity of community mobilisation approaches in trichiasis campaigns: analysis of programmatic data from seven sub-Saharan African countries.

Int Health 2022 04;14(Suppl 1):i24-i28

Sightsavers, 35 Perrymount Road, Haywards Heath, RH16 3BZ, UK.

Background: Achieving elimination of trachoma as a public health problem in trichiasis-endemic districts requires a systematic approach to trichiasis case finding and outreach.

Methods: Programme monitoring data from seven countries for 2017-2019 were used to explore the efficiency of different community mobilisation approaches and uptake of trichiasis surgical services.

Results: Three countries (Ethiopia, Kenya and Mozambique) using broad-based community mobilisation strategies had large numbers of people presenting at outreach but only 2. Read More

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Prevalence of Trachoma following Implementation of the SAFE Strategy in Three Local Government Areas of Taraba State, North Eastern Nigeria.

Ophthalmic Epidemiol 2022 Mar 30:1-9. Epub 2022 Mar 30.

Sightsavers, Nigeria Country Office, Kaduna, Nigeria.

Introduction: In 2019-2020, one round of antibiotic mass drug administration (MDA) was implemented for trachoma elimination purposes in Donga, Gashaka, and Ussa local government areas (LGAs) of Taraba State, Nigeria, following baseline surveys in 2009 (Donga and Gashaka) and 2013-2014 (Ussa). Here, trachoma prevalence post-MDA in these three LGAs is reported.

Methods: In 2019 (Gashaka and Ussa) and 2020 (Donga), population-based, cross-sectional surveys were conducted following World Health Organization (WHO) guidance. Read More

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Post-Validation Survey in Two Districts of Morocco after the Elimination of Trachoma as a Public Health Problem.

Am J Trop Med Hyg 2022 Mar 28. Epub 2022 Mar 28.

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Trachoma is the leading infectious cause of blindness. In 2016, Morocco was validated by WHO as having eliminated trachoma as a public health problem. We evaluated two previously endemic districts in Morocco for trachomatous inflammation-follicular (TF), trachomatous trichiasis (TT), and antibodies against Chlamydia trachomatis, the causative agent of trachoma. Read More

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Concordance of ompA types in children re-infected with ocular Chlamydia trachomatis following mass azithromycin treatment for trachoma.

PLoS Negl Trop Dis 2022 03 28;16(3):e0010237. Epub 2022 Mar 28.

Francis I. Proctor Foundation, University of California, San Francisco, California, United States of America.

Background: The chlamydial major outer membrane protein, encoded by the ompA gene, is a primary target for chlamydial vaccine research. However, human studies of ompA-specific immunity are limited, and prior studies have been limited in differentiating re-infection from persistent infection. The purpose of this study was to assess whether children living in trachoma-endemic communities with re-infections of ocular chlamydia were more likely to be infected with a different or similar genovar. Read More

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The Gambia has eliminated trachoma as a public health problem: Challenges and successes.

PLoS Negl Trop Dis 2022 03 28;16(3):e0010282. Epub 2022 Mar 28.

Kilimanjaro Centre for Community Ophthalmology, Division of Ophthalmology, University of Cape Town, Cape Town, South Africa.

Trachoma is the leading infectious cause of blindness in the world and has been known to be a major public health problem in The Gambia for over 60 years. Nationwide blindness surveys, including trachoma, in 1986 and 1996 provided the foundation for a comprehensive plan to implement a trachoma elimination strategy. Impact and pre-validation surveillance surveys in 2011-13 demonstrated that active trachoma was below WHO threshold for elimination but trichiasis remained a public health problem. Read More

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The economics of vision impairment and its leading causes: A systematic review.

EClinicalMedicine 2022 Apr 22;46:101354. Epub 2022 Mar 22.

National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.

Vision impairment (VI) can have wide ranging economic impact on individuals, households, and health systems. The aim of this systematic review was to describe and summarise the costs associated with VI and its major causes. We searched MEDLINE (16 November 2019), National Health Service Economic Evaluation Database, the Database of Abstracts of Reviews of Effects and the Health Technology Assessment database (12 December 2019) for partial or full economic evaluation studies, published between 1 January 2000 and the search dates, reporting cost data for participants with VI due to an unspecified cause or one of the seven leading causes globally: cataract, uncorrected refractive error, diabetic retinopathy, glaucoma, age-related macular degeneration, corneal opacity, trachoma. Read More

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Distichiasis: An update on etiology, treatment and outcomes.

Swati Singh

Indian J Ophthalmol 2022 Apr;70(4):1100-1106

Ocular Surface and Adnexa Services; Centre for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, Telangana, India.

Distichiasis, an extra row of eyelashes emerging from meibomian gland orifices, occurs due to the metaplastic transition of sebaceous glands into the pilosebaceous unit. It can present congenitally, such as in lymphedema distichiasis syndrome, or secondary to acquired conditions, such as cicatrizing conjunctivitis, trachoma. This review summarizes the etiology of distichiasis, its presentation, the evolution of various surgical techniques, and their outcomes in human and animal eyes. Read More

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Global progress toward the elimination of active trachoma: an analysis of 38 countries.

Lancet Glob Health 2022 04;10(4):e491-e500

Zimbabwe Ministry of Health, Harare, Zimbabwe.

Background: Global elimination of trachoma as a public health problem was targeted for 2020. We reviewed progress towards the elimination of active trachoma by country and geographical group.

Methods: In this retrospective analysis of national survey and implementation data, all countries ever known to be endemic for trachoma that had either implemented at least one trachoma impact survey shown in the publicly available Trachoma Atlas, or are in Africa were invited to participate in this study. Read More

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Trachoma control using water, sanitation, and hygiene - Authors' reply.

Lancet Glob Health 2022 04;10(4):e480

Francis I Proctor Foundation, University of California, San Francisco, CA, USA; Department of Ophthalmology, University of California, San Francisco, CA, USA. Electronic address:

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Trachoma control using water, sanitation, and hygiene.

Hugh R Taylor

Lancet Glob Health 2022 04;10(4):e479

Melbourne School of Population & Global Health, University of Melbourne, Carlton, VIC, Australia. Electronic address:

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