4,880 results match your criteria Trachoma


Factors shaping the implementation of the SAFE strategy for trachoma using the Consolidated Framework for Implementation Research: a systematic review.

Glob Health Action 2019 ;12(1):1570646

b Department of Epidemiology and Biostatistics, School of Public Health , University of Zambia , Lusaka , Zambia.

Background: The SAFE strategy (surgery for trichiasis, antibiotics for active infection, facial cleanliness and environmental improvement) is the World Health Organization (WHO) recommended guideline for the elimination of blindness by trachoma by the year 2020.

Objective: While evaluations on the implementation of the SAFE strategy have been done, systematic reviews on the factors that have shaped implementation are lacking. This review sought to identify these factors. Read More

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http://dx.doi.org/10.1080/16549716.2019.1570646DOI Listing
January 2019

Interventions to improve gender equity in eye care in low-middle income countries: A systematic review.

Ophthalmic Epidemiol 2019 Feb 15:1-11. Epub 2019 Feb 15.

b Seva Canada Society , Vancouver , Canada.

Purpose: Women bear an inequitable burden of blinding conditions compared to men primarily because they have more limited access to eye care services. This systematic review sought evidence regarding interventions to increase gender equity in eye care.

Methods: We searched MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, and EBSCO CINAHL, and contacted experts to identify studies in low- and middle-income countries of health services interventions for age-related cataract, childhood cataract, and trachoma. Read More

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http://dx.doi.org/10.1080/09286586.2019.1574839DOI Listing
February 2019

Sensitivity and specificity of computer vision classification of eyelid photographs for programmatic trachoma assessment.

PLoS One 2019 11;14(2):e0210463. Epub 2019 Feb 11.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, United States of America.

Background/aims: Trachoma programs base treatment decisions on the community prevalence of the clinical signs of trachoma, assessed by direct examination of the conjunctiva. Automated assessment could be more standardized and more cost-effective. We tested the hypothesis that an automated algorithm could classify eyelid photographs better than chance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210463PLOS
February 2019

Absence of Serological Evidence of Exposure to among Children Suggests Yaws Is No Longer Endemic in Kiribati.

Am J Trop Med Hyg 2019 Feb 4. Epub 2019 Feb 4.

Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Yaws is a neglected tropical disease targeted for eradication by 2020. Kiribati, a Pacific Island nation, was previously endemic for yaws but lacks recent data from which its current endemicity status could be determined. This study tested antibody responses to to determine if transmission of yaws is taking place among children in Kiribati. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0799DOI Listing
February 2019

Optimization of a rapid test for antibodies to the Chlamydia trachomatis antigen Pgp3.

Diagn Microbiol Infect Dis 2018 Nov 10. Epub 2018 Nov 10.

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address:

Serological surveillance for trachoma could allow monitoring of transmission levels in areas that have achieved elimination targets. Platforms that allow testing in basic laboratories or testing of easy-to-manage samples such as dried blood spots would contribute to the feasibility of serologic testing. Blood from 506 1-12-year-olds in 2 villages in Kongwa district, Tanzania, was tested for antibodies against the antigen Pgp3. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.11.001DOI Listing
November 2018

Effect of Adding Azithromycin to Seasonal Malaria Chemoprevention.

N Engl J Med 2019 Jan 30. Epub 2019 Jan 30.

From the London School of Hygiene and Tropical Medicine, London (D.C., M.C., I.K., P.M., B.G.); the Malaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali (A.D., I.S., M.D., A.B., A. Tapily, S.C., I.T., O.D.); and Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso (I.Z., F.N., S.Y., A. Traore, H.T., J.-B.O.).

Background: Mass administration of azithromycin for trachoma control led to a sustained reduction in all-cause mortality among Ethiopian children. Whether the addition of azithromycin to the monthly sulfadoxine-pyrimethamine plus amodiaquine used for seasonal malaria chemoprevention could reduce mortality and morbidity among African children was unclear.

Methods: We randomly assigned children 3 to 59 months of age, according to household, to receive either azithromycin or placebo, together with sulfadoxine-pyrimethamine plus amodiaquine, during the annual malaria-transmission season in Burkina Faso and Mali. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1811400
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http://dx.doi.org/10.1056/NEJMoa1811400DOI Listing
January 2019
4 Reads

Ocular Chlamydia trachomatis infection: elimination with mass drug administration.

Expert Rev Anti Infect Ther 2019 Jan 30:1-12. Epub 2019 Jan 30.

a Dana Center for Preventive Ophthalmology , Johns Hopkins Medical Institutions , Baltimore , MD , USA.

Introduction: Ocular Chlamydia trachomatis infection, the causative agent for trachoma, is responsible for 1.9 million cases of visual loss worldwide. Mass Drug Administration (MDA) with azithromycin to entire trachoma-endemic districts is part of the World Health Organization's public health strategy for trachoma elimination. Read More

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http://dx.doi.org/10.1080/14787210.2019.1577136DOI Listing
January 2019

Community-level chlamydial serology for assessing trachoma elimination in trachoma-endemic Niger.

PLoS Negl Trop Dis 2019 Jan 28;13(1):e0007127. Epub 2019 Jan 28.

Divison of Parasitic Diseases and Malaria, Centers for Disease Prevention and Control, Atlanta, Georgia, United States of America.

Background: Program decision-making for trachoma elimination currently relies on conjunctival clinical signs. Antibody tests may provide additional information on the epidemiology of trachoma, particularly in regions where it is disappearing or elimination targets have been met.

Methods: A cluster-randomized trial of mass azithromycin distribution strategies for trachoma elimination was conducted over three years in a mesoendemic region of Niger. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007127
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http://dx.doi.org/10.1371/journal.pntd.0007127DOI Listing
January 2019
4 Reads

Assessment of trachoma in suspected endemic areas within 16 provinces in mainland China.

PLoS Negl Trop Dis 2019 Jan 28;13(1):e0007130. Epub 2019 Jan 28.

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing, China.

Background: China used to be among the countries with a high prevalence of trachoma. At the launch of The Global Elimination of Trachoma (GET) 2020 campaign by the World Health Organization (WHO) in 1996, China was placed on the list of countries endemic for trachoma based on historical data. However, empirical observation and routinely collected eye care data were suggesting that trachoma was no longer a public health problem. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007130DOI Listing
January 2019
1 Read

3D images as a field grader training tool for trachomatous trichiasis: A diagnostic accuracy study in Ethiopia.

PLoS Negl Trop Dis 2019 Jan 24;13(1):e0007104. Epub 2019 Jan 24.

International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: Trachomatous trichiasis (TT) will continue to develop among those people who have had repeated infections after active trachoma is controlled. Detecting and treating affected individuals will remain necessary for years; a long "tail" of incident cases is anticipated. As the prevalence of TT declines, there will be fewer cases available for training trachoma graders (TG), necessitating alternative methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363231PMC
January 2019
4 Reads

Self-Reported Side Effects following Mass Administration of Azithromycin to Eliminate Trachoma in Amhara, Ethiopia: Results from a Region-Wide Population-Based Survey.

Am J Trop Med Hyg 2019 Jan 21. Epub 2019 Jan 21.

The Carter Center Atlanta.

A region-wide population-based post-mass drug administration (MDA) coverage survey was conducted 3 weeks following the 2016 trachoma MDA in Amhara, Ethiopia. The prevalence of self-reported side effects was assessed among those who self-reported receiving azithromycin. A total of 16,773 individuals from 5,129 households reported taking azithromycin during the 2016 MDA in Amhara. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0781DOI Listing
January 2019
2 Reads

Population coverage and factors associated with participation following a mass drug administration of azithromycin for trachoma elimination in Amhara, Ethiopia.

Trop Med Int Health 2019 Jan 23. Epub 2019 Jan 23.

Trachoma Control Program, The Carter Center, Atlanta, GA, USA.

Objectives: Mass drug administration (MDA) with azithromycin is a core component of the WHO-recommended strategy to eliminate trachoma as a public health problem, but low participation rates in MDA campaigns may undermine the effectiveness of this intervention. We explored factors associated with individual MDA participation at the individual, head of household and household levels in Amhara, Ethiopia.

Methods: We conducted four district-level, multilevel cluster random coverage surveys to collect data on self-reported MDA participation and predictors. Read More

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http://dx.doi.org/10.1111/tmi.13208DOI Listing
January 2019
1 Read

How to improve Iranians' vision health: on the national policy of preventing Iranians' blindness.

Int J Ophthalmol 2019 18;12(1):114-122. Epub 2019 Jan 18.

Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran 1445613113, Iran.

Aim: To review vision health situation of Iranian community, analyze its determinants, and discuss the adopted improvement strategies by the Iran Ministry of Health and Medical Education (MOHME).

Methods: This was a rapid situation analysis with a qualitative approach in three parts of recognition, orientation and implementation. The data were gathered review of upstream documents, national and international experiences, and experts and stakeholders' opinions. Read More

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http://dx.doi.org/10.18240/ijo.2019.01.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326938PMC
January 2019
0.500 Impact Factor

The Ocular Microbiome: Molecular Characterisation of a Unique and Low Microbial Environment.

Curr Eye Res 2019 Jan 14:1-10. Epub 2019 Jan 14.

a School of Optometry and Vision Science , University of New South Wales , Sydney , Australia.

Aim: The ocular surface is continually exposed to bacteria from the environment and traditional culture-based microbiological studies have isolated a low diversity of microorganisms from this region. The use of culture-independent methods to define the ocular microbiome, primarily involving 16S ribosomal RNA gene sequencing studies, have shown that the microbial communities present on the ocular surface have a greater diversity than previously reported.

Method: A review of the literature on ocular microbiome research in health and disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/02713683.2019.1
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http://dx.doi.org/10.1080/02713683.2019.1570526DOI Listing
January 2019
6 Reads

Ophthalmia Neonatorum.

Authors:
Aik-Kah Tan

N Engl J Med 2019 Jan;380(2):e2

Normah Medical Specialist Center, Kuching, Malaysia

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http://dx.doi.org/10.1056/NEJMicm1808613DOI Listing
January 2019

Genetic Transformation of a Ocular Isolate With the Functional Tryptophan Synthase Operon Confers an Indole-Rescuable Phenotype.

Front Cell Infect Microbiol 2018 14;8:434. Epub 2018 Dec 14.

Molecular Microbiology Group, Department of Clinical and Experimental Science, Southampton General Hospital, University Medical School, Southampton, United Kingdom.

is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this tissue tropism is the active tryptophan biosynthesis pathway encoded by the genomic operon in urogenital strains. Here we describe genetic complementation studies that are essential to confirm the role of tryptophan synthase in the context of an ocular genomic background. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00434
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http://dx.doi.org/10.3389/fcimb.2018.00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302012PMC
December 2018
8 Reads

Mass Azithromycin Distribution to Prevent Childhood Mortality: A Pooled Analysis of Cluster-Randomized Trials.

Am J Trop Med Hyg 2019 Jan 2. Epub 2019 Jan 2.

Department of Ophthalmology, University of California, San Francisco, San Francisco, California.

Mass drug administration (MDA) with azithromycin may reduce under-5 child mortality (U5M) in sub-Saharan Africa. Here, we conducted a pooled analysis of all published cluster-randomized trials evaluating the effect of azithromycin MDA on child mortality. We pooled data from cluster-randomized trials randomizing communities to azithromycin MDA versus control. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0846
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http://dx.doi.org/10.4269/ajtmh.18-0846DOI Listing
January 2019
3 Reads

Exploring the role of programmed cell death protein 1 and its ligand 1 in eye diseases.

Crit Rev Clin Lab Sci 2019 Jan 3;56(1):18-32. Epub 2019 Jan 3.

a Tianjin Medical University Eye Hospital , Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University , Tianjin , China.

Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1/PD-L1-mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceuticals and immunotherapy. Furthermore, monoclonal antibodies to PD-1 have just been approved by the US Food and Drug Administration to treat certain types of malignancies. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1522292DOI Listing
January 2019
11 Reads

Optimising age adjustment of trichiasis prevalence estimates using data from 162 standardised surveys from seven regions of Ethiopia.

Ophthalmic Epidemiol 2018 Dec 28:1-8. Epub 2018 Dec 28.

a Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: The prevalence of trichiasis is higher in females and increases markedly with age. Surveys carried out in the daytime, particularly in developing countries, are prone to find older individuals and females at home at the time of the survey. Population-level trichiasis estimates should adjust sample proportions to reflect the demographic breakdown of the population, although the most accurate method of doing this is unclear. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
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http://dx.doi.org/10.1080/09286586.2018.1555262DOI Listing
December 2018
4 Reads
1.271 Impact Factor

Trachoma and Herbert's Pits.

QJM 2018 Dec 24. Epub 2018 Dec 24.

Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.

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http://dx.doi.org/10.1093/qjmed/hcy296DOI Listing
December 2018
12 Reads

Trachoma control: the SAFE strategy.

Int J Ophthalmol 2018 18;11(12):1887-1888. Epub 2018 Dec 18.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Vision Science Key Lab, Beijing 100730, China.

As a contagious bacterial infection that affects the conjunctival covering of the eye, the cornea and the eyelids, trachoma is controlled by an endorsed integrated strategy consisting of surgery for trichiasis, antibiotic therapy, facial cleanliness and environmental improvement, namely, the SAFE strategy developed by World Health Organization. Developed based on evidence from previous field trials and constantly modified in practice, SAFE strategy has greatly boosted the progress in trachoma control. Regardless of the fact that there are still many pending questions, national program coordinators are convinced that trachoma control initiative based on SAFE strategy would be effective. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.12.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288535PMC
December 2018
7 Reads

The utility of serology for elimination surveillance of trachoma.

Nat Commun 2018 12 21;9(1):5444. Epub 2018 Dec 21.

Malaria: Parasites & Hosts, Department of Parasites and Insect Vectors, Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France.

Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Analyses with sero-catalytic and antibody acquisition models provide insights into transmission history within each population. Read More

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http://www.nature.com/articles/s41467-018-07852-0
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http://dx.doi.org/10.1038/s41467-018-07852-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303365PMC
December 2018
10 Reads

Achieving the endgame: Integrated NTD case searches.

PLoS Negl Trop Dis 2018 12 20;12(12):e0006623. Epub 2018 Dec 20.

The Carter Center, Atlanta, Georgia, United States of America.

Trachoma and Guinea Worm Disease (GWD) are neglected tropical diseases (NTD) slated for elimination as a public health problem and eradication respectively by the World Health Organization. As these programs wind down, uncovering the last cases becomes an urgent priority. In 2010, Ghana Health Services, along with The Carter Center, Sightsavers, and other partners, conducted integrated case searches for both GWD and the last stage of trachoma disease, trachomatous trichiasis (TT), as well as providing surgical treatment for TT to meet elimination (and eradication targets). Read More

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http://dx.plos.org/10.1371/journal.pntd.0006623
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http://dx.doi.org/10.1371/journal.pntd.0006623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319769PMC
December 2018
8 Reads

Trachoma in 3 Amerindian Communities, Venezuelan Amazon, 2018.

Emerg Infect Dis 2019 Jan;25(1)

Trachoma is among the most common infectious causes of blindness. During January-May 2018, a total of 4 trachoma cases were diagnosed among Amerindians of the Yanomami ethnic group in 3 communities of southern Venezuela. This country has social and environmental conditions conducive to the endemicity of this neglected tropical disease. Read More

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http://wwwnc.cdc.gov/eid/article/25/1/18-1362_article.htm
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http://dx.doi.org/10.3201/eid2501.181362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302605PMC
January 2019
8 Reads

Serological and PCR-based markers of ocular Chlamydia trachomatis transmission in northern Ghana after elimination of trachoma as a public health problem.

PLoS Negl Trop Dis 2018 12 14;12(12):e0007027. Epub 2018 Dec 14.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Validation of elimination of trachoma as a public health problem is based on clinical indicators, using the WHO simplified grading system. Chlamydia trachomatis (Ct) infection and anti-Ct antibody responses (anti-Pgp3) have both been evaluated as alternative indicators in settings with varying levels of trachoma. There is a need to evaluate the feasibility of using tests for Ct infection and anti-Pgp3 antibodies at scale in a trachoma-endemic country and to establish the added value of the data generated for understanding transmission dynamics in the peri-elimination setting. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007027
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http://dx.doi.org/10.1371/journal.pntd.0007027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310292PMC
December 2018
5 Reads

Evaluation of a Single Dose of Azithromycin for Trachoma in Low-Prevalence Communities.

Ophthalmic Epidemiol 2019 Feb 13;26(1):1-6. Epub 2018 Dec 13.

a Division of Parasitic Diseases and Malaria , Centers for Disease Control and Prevention , Atlanta , GA , USA.

Purpose: Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is the leading infectious cause of blindness worldwide and is targeted for elimination as a public health problem. We sought to determine whether a one-time azithromycin mass treatment would reduce trachomatous inflammation-follicular (TF) levels below the elimination threshold of 5% in communities with disease prevalence between 5 and 9.9%. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2017.1
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http://dx.doi.org/10.1080/09286586.2017.1293693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352373PMC
February 2019
9 Reads

The History of Trachoma and Current Prevalence (Spotlight on Iran): A Review Article.

Iran J Public Health 2018 Oct;47(10):1458-1465

Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Background: Trachoma as a common cause of infectious blindness is caused by . This study aimed to review the available data from variety of sources and provide an overview of the epidemiological situation of Trachoma in Iran focused on the past seventy five years.

Methods: A literature search of English and Farsi articles regarding trachoma in Iran from the electronic databases and paper documents was performed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277721PMC
October 2018
6 Reads

Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation Reduces Infectivity Independent of Targeted Cytokine Inhibition.

Front Microbiol 2018 15;9:2757. Epub 2018 Nov 15.

Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

is the major cause of infectious blindness and represents the most common bacterial sexually transmitted infection worldwide. Considering the potential side effects of antibiotic therapy and increasing threat of antibiotic resistance, alternative therapeutic strategies are needed. Previous studies showed that water filtered infrared A alone (wIRA) or in combination with visible light (wIRA/VIS) reduced infectivity. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02757
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http://dx.doi.org/10.3389/fmicb.2018.02757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262300PMC
November 2018
8 Reads

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

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http://dx.doi.org/10.4103/ojo.OJO_4_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219341PMC
December 2018
2 Reads

Celebrating 20 years of progress: accelerating towards elimination.

Community Eye Health 2018 ;31(103):73

Special Projects and Campaigns: International Coalition for Trachoma Control London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253308PMC
January 2018

Behavioural change interventions for sustained trachoma elimination.

Bull World Health Organ 2018 Oct 10;96(10):723-725. Epub 2018 Sep 10.

Sightsavers, London, England.

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http://dx.doi.org/10.2471/BLT.18.212514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238993PMC
October 2018
2 Reads

A systematic review of historical and contemporary evidence of trachoma endemicity in the Pacific Islands.

PLoS One 2018 15;13(11):e0207393. Epub 2018 Nov 15.

Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Introduction: Trachoma is endemic in several Pacific Island countries. The aims of this study were to (a) identify future trachoma mapping needs in the Pacific and (b) to examine whether any temporal trends in trachoma prevalence could be ascertained from the historical literature on trachoma in the Pacific Islands.

Methods: Human studies of trachoma and eye care in the Pacific Islands were identified from a systematic search of PubMed, EMbase, Scopus and Web of Science databases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207393PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237375PMC
November 2018
9 Reads

Safety of azithromycin in infants under six months of age in Niger: A community randomized trial.

PLoS Negl Trop Dis 2018 11 12;12(11):e0006950. Epub 2018 Nov 12.

Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America.

Background: Mass azithromycin distribution reduces under-5 child mortality. Trachoma control programs currently treat infants aged 6 months and older. Here, we report findings from an infant adverse event survey in 1-5 month olds who received azithromycin as part of a large community-randomized trial in Niger. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006950
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http://dx.doi.org/10.1371/journal.pntd.0006950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258425PMC
November 2018
12 Reads

Prevalence and causes of blindness and vision impairment: magnitude, temporal trends and projections in South and Central Asia.

Br J Ophthalmol 2018 Nov 8. Epub 2018 Nov 8.

Vision and Eye Research Unit, School of Medicine, Anglia Ruskin University, Cambridge, UK

Background: To assess prevalence and causes of vision loss in Central and South Asia.

Methods: A systematic review of medical literature assessed the prevalence of blindness (presenting visual acuity<3/60 in the better eye), moderate and severe vision impairment (MSVI; presenting visual acuity <6/18 but ≥3/60) and mild vision impairment (MVI; presenting visual acuity <6/12 and ≥6/18) in Central and South Asia for 1990, 2010, 2015 and 2020.

Results: In Central and South Asia combined, age-standardised prevalences of blindness, MSVI and MVI in 2015 were for men and women aged 50+years, 3. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3122
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http://dx.doi.org/10.1136/bjophthalmol-2018-312292DOI Listing
November 2018
11 Reads
2.980 Impact Factor

Comment on: 'Association of Chlamydia trachomatis ompA genovar with trachoma phenotypes'.

Authors:
Hugh Taylor

Eye (Lond) 2018 Nov 2. Epub 2018 Nov 2.

University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1038/s41433-018-0266-1DOI Listing
November 2018
1 Read

In vitro activities of a new fluoroquinolone derivative highly active against Chlamydia trachomatis.

Bioorg Chem 2019 Mar 19;83:180-185. Epub 2018 Oct 19.

Univ Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086, CNRS, 15 rue Jean Antoine de Baïf, F-75205 Paris, France. Electronic address:

Chlamydia trachomatis is a bacterial human pathogen responsible for the development of trachoma, an infection leading to blindness, and is also the cause of the main bacterial sexually transmitted infection worldwide. We designed a new inhibitor of this bacterium with, however, some prerequisites using (i) the iron dependency of the bacterium, (ii) a commercially available broad-spectrum antibiotic and (iii) a short synthetic pathway. The corresponding 8-hydroxyquinoline-ciprofloxacin conjugate was evaluated against a panel of pathogenic bacteria, including C. Read More

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http://dx.doi.org/10.1016/j.bioorg.2018.10.033DOI Listing
March 2019
2 Reads

Imagining eye care in India (2018 Lalit Prakash Agarwal lecture).

Indian J Ophthalmol 2018 Nov;66(11):1532-1538

Indian Oil Center for Rural Eye Health, L V Prasad Eye Institute, Bhubaneswar, Odisha, India.

India has done well in eye care delivery by recognizing visual impairment and blindness as a major medical challenge. Major contributions have come from ophthalmologists (mass cataract surgery in the early 1900s; major participation of non-government organizations), policy makers (National Program for Control of Blindness and Visual Impairment 1976; systematic development under the World Bank assisted India Cataract Project, 1995-2002), and the industry (manufacturing of affordable surgical instruments and medicines). Although the country could boast of higher cataract surgical coverage and near-total elimination of trachoma, there is increasing prevalence of diabetic retinopathy and undetected glaucoma. Read More

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http://www.ijo.in/text.asp?2018/66/11/1532/244080
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http://dx.doi.org/10.4103/ijo.IJO_872_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213694PMC
November 2018
7 Reads

Active trachoma among children of District Dera Ghazi Khan, Punjab, Pakistan: A cross sectional study.

J Pak Med Assoc 2018 Sep;68(9):1300-1303

Ameer ud Din Medical College, PGMI, Lahore.

Objective: This study was conducted to determine the prevalence of trachoma among children of age one month to 15 years.

Methods: Community based cross sectional study was conducted in district Dera Ghazi Khan from January to December 2014. The simple random sampling technique was employed. Read More

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September 2018

Optimising sampling regimes and data collection to inform surveillance for trachoma control.

PLoS Negl Trop Dis 2018 10 11;12(10):e0006531. Epub 2018 Oct 11.

Big Data Institute, Li Ka Shing Centre for Health Informatics, University of Oxford, Oxford, United Kingdom.

It is estimated that 190 million individuals are at risk of blindness from trachoma, and that control by mass drug administration (MDA) is reducing this risk in many populations. Programs are monitored using prevalence of follicular trachoma disease (TF) in children. However, as programs progress to low prevalence there are challenges interpreting this indirect measure of infection. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006531
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http://dx.doi.org/10.1371/journal.pntd.0006531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181273PMC
October 2018
1 Read

Development of a rapid colorimetric multiplex PCR-reverse line blot for the detection and typing of 14 Chlamydia trachomatis genovars.

J Med Microbiol 2018 Oct 10. Epub 2018 Oct 10.

3​Department of Obstetrics and Gynaecology, University of Melbourne, Australia.

Purpose: Chlamydia trachomatis is responsible for trachoma-associated blindness as well as the most common sexually transmitted bacterial infection worldwide, although the genovars for the former are typically A-C, whilst for the latter they are D-K and for the uncommon infection lymphogranuloma venereum they are L1-3. Nucleotide variations within the ompA gene facilitate the identification of C. trachomatis genovars. Read More

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http://www.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.000836DOI Listing
October 2018
9 Reads

Identifying a sufficient core group for trachoma transmission.

PLoS Negl Trop Dis 2018 10 8;12(10):e0006478. Epub 2018 Oct 8.

F.I. Proctor Foundation, University of California San Francisco, San Francisco, CA, United States of America.

Background: In many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would disappear in the remainder of the community. No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006478
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http://dx.doi.org/10.1371/journal.pntd.0006478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175502PMC
October 2018
9 Reads

Antimicrobial resistance following mass azithromycin distribution for trachoma: a systematic review.

Lancet Infect Dis 2019 Jan 3;19(1):e14-e25. Epub 2018 Oct 3.

Francis I Proctor Foundation, University of California, San Francisco, CA, USA; Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA. Electronic address:

Mass azithromycin distribution is a core component of trachoma control programmes and could reduce mortality in children younger than 5 years in some settings. In this systematic review we synthesise evidence on the emergence of antimicrobial resistance after mass azithromycin distribution. We searched electronic databases for publications up to June 14, 2018. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30444-4DOI Listing
January 2019
13 Reads

Trachoma prevalence remains below threshold in five districts after stopping mass drug administration: results of five surveillance surveys within a hyperendemic setting in Amhara, Ethiopia.

Trans R Soc Trop Med Hyg 2018 Dec;112(12):538-545

Trachoma Control Program, The Carter Center, Atlanta, GA, USA.

Background: The World Health Organization (WHO) recommends conducting trachoma surveillance surveys in districts where the elimination targets have been met and following a minimum 2-year period after cessation of mass drug administration (MDA) in order to determine the sustainability of low trachoma levels.

Methods: In 2015, population-based surveillance surveys were conducted in five districts of Amhara, Ethiopia. All five districts had a prior trachomatous inflammation-follicular (TF) prevalence among children 1-9 y of age of <5% determined by an impact survey and had not received MDA for ≥2 y. Read More

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http://dx.doi.org/10.1093/trstmh/try096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255692PMC
December 2018
4 Reads

Health risk perceptions and local knowledge of water-related infectious disease exposure among Kenyan wetland communities.

Int J Hyg Environ Health 2019 Jan 24;222(1):34-48. Epub 2018 Sep 24.

GeoHealth Centre, Institute for Hygiene & Public Health, University Hospital Bonn, Germany; Center for Development Research (ZEF), University of Bonn, Germany.

Background: Risk perceptions have the potential of motivating and shaping health-related behaviour, i.e. the application of protective health measures. Read More

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http://dx.doi.org/10.1016/j.ijheh.2018.08.003DOI Listing
January 2019
7 Reads

Feasibility and safety of mass drug coadministration with azithromycin and ivermectin for the control of neglected tropical diseases: a single-arm intervention trial.

Lancet Glob Health 2018 Oct;6(10):e1132-e1138

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Background: Mass drug administration has made a major contribution to the public health control of several important neglected tropical diseases. For settings with more than one endemic disease, combined mass drug administration has potential practical advantages compared with separate programmes but needs confirmation of feasibility and safety. We undertook a study of mass drug administration in the Solomon Islands for trachoma and scabies control using ivermectin and azithromycin, key drugs in the control of neglected tropical diseases worldwide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X183039
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http://dx.doi.org/10.1016/S2214-109X(18)30397-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139784PMC
October 2018
7 Reads

Achieving universal eye health coverage: planning and human resource lessons from trachoma.

Community Eye Health 2018 ;31(102):54

Communications Specialist: International Coalition for Trachoma Control London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134455PMC
January 2018

Mass antibiotic distribution to reduce mortality among preschool children?

Arch Dis Child 2019 Mar 14;104(3):227-228. Epub 2018 Sep 14.

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/archdischild-2018-315451DOI Listing

Prevalence and causes of vision loss in South-east Asia and Oceania in 2015: magnitude, temporal trends and projections.

Br J Ophthalmol 2018 Sep 12. Epub 2018 Sep 12.

Vision & Eye Research Unit, Anglia Ruskin University, Cambridge, UK.

Background: To assess prevalence and causes of vision impairment in South-east Asia and Oceania regions from 1990 to 2015 and to forecast the figures for 2020.

Methods: Based on a systematic review of medical literature, prevalence of blindness (presenting visual acuity (PVA) <3/60 in the better eye), moderate and severe vision impairment (MSVI; PVA <6/18 but ≥3/60), mild vision impairment (PVA <6/12 but ≥6/18) and near vision impairment (>N5 or N8 in the presence of normal vision) were estimated for 1990, 2010, 2015 and 2020.

Results: The age-standardised prevalence of blindness for all ages and both genders was higher in the Oceania region but lower for MSVI when comparing the subregions. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3119
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-311946DOI Listing
September 2018
8 Reads
2.980 Impact Factor

Prevalence and causes of vision loss in North Africa and Middle East in 2015: magnitude, temporal trends and projections.

Br J Ophthalmol 2018 Sep 12. Epub 2018 Sep 12.

Vision and Eye Research Unit, School of Medicine, Anglia Ruskin University, Cambridge, UK.

Background: To assess the prevalence and causes of vision impairment in North Africa and the Middle East (NAME) from 1990 to 2015 and to forecast projections for 2020.

Methods: Based on a systematic review of medical literature, the prevalence of blindness (presenting visual acuity (PVA) <3/60 in the better eye), moderate and severe vision impairment (MSVI; PVA <6/18 but ≥3/60) and mild vision impairment (PVA <6/12 but ≥6/18) was estimated for 2015 and 2020.

Results: The age-standardised prevalence of blindness and MSVI for all ages and genders decreased from 1990 to 2015, from 1. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3120
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-312068DOI Listing
September 2018
8 Reads
2.980 Impact Factor