75,298 results match your criteria Tracheal Tumors


Impact of surfactant administration through a thin catheter in the delivery room: A quality control chart analysis coupled with a propensity score matched cohort study in preterm infants.

PLoS One 2018 12;13(12):e0208252. Epub 2018 Dec 12.

Department of Pediatrics, University of Rennes 1,Rennes, France.

Introduction: Most infants born before 30 weeks gestational age (GA) develop respiratory distress syndrome soon after birth. Methods of surfactant administration that avoid ventilation have been recently introduced. The aim of this study was to evaluate the impact of implementing a new procedure of less invasive surfactant administration (LISA) and determine whether it is associated with an improvement in respiratory outcome. Read More

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December 2018

Use of tracheal ultrasound combined with clinical parameters to select left double-lumen tube size: A prospective observational study.

Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anesthesiology and Intensive Care, C.H.U. Dijon (ER, PI, P-GG, BB, OD-R), Dijon and Université Bourgogne Franche-Comté, LNC UMR866, Dijon Cedex, France (P-GG, BB, OD-R), Anaesthesia and Intensive Care, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy (SM, FM) and Unit of Anaesthesia and Intensive Care, Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy (ER, FM).

Background: Left double-lumen tubes (LDLTs) are used in thoracic surgery to allow one-lung ventilation. Their size is usually chosen on the basis of clinical parameters (height, sex). Double-lumen endobronchial tubes are frequently undersized/oversized, risking tube displacement or tracheal trauma. Read More

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December 2018

Unplanned extubations in general intensive care unit: A nine-year retrospective analysis.

Acta Biomed 2018 Dec 7;89(7-S):25-31. Epub 2018 Dec 7.

ASST Monza, Ospedale San Gerardo - università degli Studi di Milano-Bicocca.

Background And Aim: Unplanned extubation (UE) in Intensive Care Units (ICU) is an indicator of quality and safety of care. UEs are classified in: accidental extubations, if involuntarily caused during nursing care or medical procedures; self-extubation, if determined by the patient him/herself.  In scientific literature, the cumulative incidence of UEs varies from 0. Read More

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December 2018
3 Reads

Comparison of the Whole Cell Proteome and Secretome of Epidemic Strains From the 2008-2012 Australian Epidemic Under Sulfate-Modulating Conditions.

Front Microbiol 2018 27;9:2851. Epub 2018 Nov 27.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.

Sulfate is an important modulator for virulence factor expression in , the causative organism for whooping cough. During infection, sulfate is released when respiratory epithelial cells are damaged which can affect gene expression. The current predominant strains in Australia are found in single nucleotide polymorphism (SNP) cluster I (). Read More

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November 2018

TNFα-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia.

Pediatr Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Inflammation is a key factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Tumor necrosis factor-stimulated protein 6 (TSG-6) is a glycoprotein that modulates inflammation. Here we tested the hypothesis that intra-tracheal (IT) administration of an adenovirus overexpressing TSG-6 (AdTSG-6) would decrease inflammation and restore lung structure in experimental BPD. Read More

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December 2018

Neonatal Intubation Practice and Outcomes: An International Registry Study.

Pediatrics 2018 Dec 11. Epub 2018 Dec 11.

Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background And Objectives: Neonatal tracheal intubation is a critical but potentially dangerous procedure. We sought to characterize intubation practice and outcomes in the NICU and delivery room (DR) settings and to identify potentially modifiable factors to improve neonatal intubation safety.

Methods: We developed the National Emergency Airway Registry for Neonates and collected standardized data for patients, providers, practices, and outcomes of neonatal intubation. Read More

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December 2018

Is continuous better than intermittent control of tracheal cuff pressure? A meta-analysis.

Nurs Crit Care 2018 Dec 9. Epub 2018 Dec 9.

Children's Hospital of Nanjing Medical University, Nanjing, China.

Aim: To compare and evaluate the efficacy and safety of continuous and intermittent control of P .

Methods: We performed a comprehensive and systematic meta-analysis of randomized controlled trials (RCTs) assessing the continuous and intermittent control of P by searching PUBMED, EMBASE and other such databases (from inception to 31 March 2018). Summary odds ratios or mean differences with 95% confidence intervals were calculated using a fixed- or random-effects model. Read More

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December 2018
0.868 Impact Factor

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock.

Cochrane Database Syst Rev 2018 Dec 10;12:CD010593. Epub 2018 Dec 10.

Intensive Care Unit, Second Affiliated Hospital Medical College, Zhejiang University, 88 Jiefang Road, Hangzhou, China, 310009.

Background: Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Whether conservative or liberal fluid therapy can improve clinical outcomes in patients with sepsis and septic shock remains unclear. Read More

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December 2018
2 Reads

An In-depth Perspective of Aortic Arch Branching in Fetal Vascular Rings Using Spatiotemporal Image Correlation Combined With High-definition Flow Imaging: Report of 4 Cases.

J Ultrasound Med 2018 Dec 11. Epub 2018 Dec 11.

Pediatric Cardiology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.

On the basis of 2-dimensional fetal echocardiographic findings, we investigated 4 different fetal vascular ring cases using spatiotemporal image correlation (STIC) combined with high-definition (HD) flow imaging. An in-depth 3-dimensional perspective of aortic arch branching (ie, the brachiocephalic arteries) was created by application of glass body and HDlive flow rendering algorithms (GE Healthcare, Zipf, Austria). Additionally, complete (U- or O-shaped) or incomplete (C-shaped) vascular rings were clearly differentiated in utero, and articulations around the trachea and esophagus were more easily imaged. Read More

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December 2018
1 Read

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

Central compartment revision surgery for persistent or recurrent thyroid carcinoma: analysis of survival and complication rate.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena, Italy.

Purpose: Locoregional recurrence of thyroid carcinoma is relatively common and reported rate are between 5 and 20%. Cervical nodes are usually involved, especially at the central compartment. The management of recurrent thyroid carcinoma at central compartment still remains challenging because of higher incidence of complication rate. Read More

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December 2018

Complete Genomic Sequences of Highly Pathogenic H5N1 Avian Influenza Viruses Obtained Directly from Human Autopsy Specimens.

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

The complete genomic sequences of H5N1 highly pathogenic avian influenza (HPAI) viruses were directly obtained from lung, trachea, and colon tissues and an intestinal fecal sample of a patient by using the next-generation sequencing technique. This is the first report on complete H5N1 viral genomes from human autopsy specimens. Read More

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December 2018

Feasibility of On-table Extubation After Cardiac Surgery with Cardiopulmonary Bypass: A Randomized Clinical Trial.

Anesth Pain Med 2018 Oct 24;8(5):e80158. Epub 2018 Sep 24.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: The use of short-acting anesthetics, muscle relaxation, and anesthesia depth monitoring allows maintaining sufficient anesthesia depth, fast recovery, and extubation of the patients in the operating room (OR). We evaluated the feasibility of extubation in the OR in cardiac surgery.

Methods: This clinical trial was performed on 100 adult patients who underwent elective noncomplex cardiac surgery using cardiopulmonary bypass. Read More

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October 2018

A Large Substernal Goiter that Extended to Both Sides of the Thorax.

Case Rep Surg 2018 5;2018:6107982. Epub 2018 Nov 5.

Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

Most substernal goiters can be managed through the transcervical approach, but a sternotomy is required in some cases. This report is about a large substernal goiter, which was resected via a transcervical and full sternotomy approach. The patient was a 57-year-old female, who visited our hospital for surgical treatment for a large substernal goiter. Read More

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November 2018

A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) 2007-2016.

Infect Drug Resist 2018 15;11:2311-2319. Epub 2018 Nov 15.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China,

Objective: This study aimed to determine the risk factors for intra-abdominal infections (IAIs), assess the clinical outcomes of IAIs, and investigate the spectrum and antimicrobial resistance of major pathogens causing IAIs.

Patients And Methods: This prospective observational study enrolled patients from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) program between 2007 and 2016. Data on the clinicopathological factors and causative pathogens were collected. Read More

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November 2018

C-MAC D-BLADE for awake oro-tracheal intubation with minimal mouth opening - A safe alternative to fibreoptic bronchoscope.

Indian J Anaesth 2018 Nov;62(11):916-918

Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

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November 2018

[Long-term oucomes of tracheal transplantation: success and unsolved problems].

Khirurgiia (Mosk) 2018 (11):11-19

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To analyze long-term outcomes of tracheal transplantation.

Material And Methods: There were 1128 patients with cicatricial tracheal stenosis who have been operated at the Petrovsky Russian Research Center for Surgery and the Sechenov First Moscow State Medical University for the period 1963-2015.

Results: Operations have become safer. Read More

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January 2018

Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury.

Shock 2018 May 4. Epub 2018 May 4.

Div. of Surgical Research/Department of Surgery, Lifespan-Rhode Island Hospital and Brown University, Providence, RI, USA.

Therapeutic interventions to treat acute lung injury (ALI) remain largely limited to lung-protective strategies, as a real molecular pathophysiologically driven therapeutic intervention has yet to become available. While we have previously documented the expression of HVEM on leukocytes of septic mice and critically ill patients, its functional role in shock/sepsis-induced ALI has not yet been studied. Inasmuch; a murine model of indirect ALI (iALI) was induced by hemorrhagic shock (HEM) followed by cecal ligation and puncture (CLP), septic challenge and HVEM-siRNA or PBS was administrated by intra-tracheal instillation 2 hours after hemorrhage to determine the role of HVEM in the development of experimental iALI. Read More

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Ultralow Dose Dynamic Expiratory Computed Tomography for Evaluation of Tracheomalacia.

J Comput Assist Tomogr 2018 Dec 7. Epub 2018 Dec 7.

Northwell Health Thoracic Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

Objective: The aim of this study was to determine the average effective radiation dose and feasibility of ultralow dose dynamic expiratory computed tomography (CT) for evaluation of tracheomalacia (ULD) and to evaluate factors that impact image quality.

Methods: This is a retrospective study of 64 consecutive patients from September to October 2016 for the evaluation of tracheomalacia. All studies were performed with routine inspiration chest CT followed by ULD z(kilovoltage peak (kVp) 80, 100, or 120 and fixed milliamperage 10) or typical dose CT (TD) (kVp 100 or 120 with automated milliamperage) dynamic expiration CT. Read More

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December 2018

Determining correct tracheal tube insertion depth by measuring distance between endotracheal tube cuff and vocal cords by ultrasound in Chinese adults: a prospective case-control study.

BMJ Open 2018 Dec 6;8(12):e023374. Epub 2018 Dec 6.

Department of Anesthesiology, Peking University Third Hospital, Beijing, China.

Objectives: Unrecognised malposition of the endotracheal tube can lead to severe complications in patients under general anaesthesia. The purpose of this study was to verify the feasibility of using ultrasound to measure the distance between the upper edge of saline-inflated cuff and the vocal cords.

Design: Prospective case-control study. Read More

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December 2018

Video-assisted thoracic surgical repair of the airway.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Thoracic Surgery Department, Hospital Universitari la Ribera. Alzira (Spain).

We communicate the first reported application of video-assisted thoracic surgery for early repair of a post-intubation tracheal laceration. The patient was a 60-year-old male. After an initial unsuccessful approach with conservative measures, surgical repair was indicated. Read More

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December 2018

Pathological and molecular investigation of porcine sapelovirus infection in naturally affected Indian pigs.

Microb Pathog 2018 Dec 5. Epub 2018 Dec 5.

Division of Pathology, ICAR- Indian Veterinary Research Institute, Bareilly, Izatnagar, 243 122, U.P, India. Electronic address:

The aim of the present study was to pathological and molecular investigation of porcine sapelovirus (PSV) in naturally infected Indian pigs of various age groups. Eight samples (16%) out of 49 necropsied animals were positive for PSV on the basis of pathological and molecular investigation. Major lesions of PSV positive cases were thickening and clouding of meninges, congestion in brain, severe to moderate congestion in lungs along with froathy exudates in trachea, thickening of intestinal mucosa, especially mucosal folds of ileum. Read More

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December 2018

Single-cell branching morphogenesis in the Drosophila trachea.

Authors:
Benedikt T Best

Dev Biol 2018 Dec 4. Epub 2018 Dec 4.

European Molecular Biology Laboratory (EMBL), Director's Research Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany; Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences.

The terminal cells of the tracheal epithelium in Drosophila melanogaster are one of the few known cell types that undergo subcellular morphogenesis to achieve a stable, branched shape. During the animal's larval stages, the cells repeatedly sprout new cytoplasmic processes. These grow very long, wrapping around target tissues to which the terminal cells adhere, and are hollowed by a gas-filled subcellular tube for oxygen delivery. Read More

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December 2018

Inhalational injury and the larynx: A review.

Burns 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatrics Otolaryngology Head & Neck Surgery, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Western Australia 6008, Australia; Murdoch ENT, Wexford Medical Centre, St John of God Hospital (Murdoch), Suite 17-18, Level 1, 3 Barry Marshall Parade, Murdoch, Western Australia 6150, Australia; School of Surgery, University of Western Australia, Stirling Highway, Crawley, Perth, Western Australia 6009, Australia; St John of God Hospital (Murdoch), Wexford Medical Center, Suite 17-18, Level 1, 3 Barry Marshall Parade, Murdoch 6150, Western Australia, Australia.

Objective: To review and discuss the existing research on the pathophysiology, impact and management of inhalational injury on the larynx and lower respiratory tract.

Data Sources: A literature search was conducted on the PubMed, MedLine, Embase, Web of Science and Google Scholar databases based on the keywords "airway burn", "inhalational injury" and "larynx".

Review Methods: Inclusion criteria included English language studies containing original and review data on airway injury. Read More

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December 2018

Use of midazolam in combination with medetomidine for premedication in healthy dogs.

Vet Anaesth Analg 2018 Aug 30. Epub 2018 Aug 30.

School of Veterinary Medicine, University of Bristol, Langford, Bristol, UK.

Objective: To assess the sedative effects, propofol sparing properties and impact on quality of induction and intubation of intravenous (IV) medetomidine and midazolam administered consecutively at different doses compared to medetomidine alone in healthy dogs for premedication.

Study Design: Prospective, randomized, blinded, clinical study.

Animals: A total of 40 adult healthy client owned dogs, weighing 18 ± 7 kg (mean ± standard deviation). Read More

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Tailored Management of Airway Abnormalities in Children with Congenital Single Functional Lung.

J Pediatr Surg 2018 Oct 30. Epub 2018 Oct 30.

Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London, UK. Electronic address:

Objectives: Pediatric patients born with single functional lung can be associated with symptomatic airway abnormalities. Management of such patients is not only technically demanding but is also ethically challenging. This study reports our experience of managing symptomatic airway abnormalities in pediatric patients with congenital single functional lung. Read More

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October 2018

Video screen viewing and first intubation attempt success with standard geometry video laryngoscope use.

Am J Emerg Med 2018 Oct 16. Epub 2018 Oct 16.

Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, United States of America; Department of Emergency Medicine, University of Minnesota Medical School, 717 Delaware Street SE, Suite 508, Minneapolis, MN 55414, United States of America. Electronic address:

Study Objectives: Direct laryngoscopy (DL) is the traditional approach for emergency intubation but video laryngoscopy (VL) is gaining popularity. Some studies have demonstrated higher first-attempt success with VL, particularly in difficult airways. In real-world settings, physicians choose whether or not to view the video screen when utilizing VL devices for tracheal intubation. Read More

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October 2018

Comparative features of infections of two Massachusetts (Mass) infectious bronchitis virus (IBV) variants isolated from Western Canadian layer flocks.

BMC Vet Res 2018 Dec 10;14(1):391. Epub 2018 Dec 10.

Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center 2C53, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.

Background: Infectious bronchitis virus (IBV) is one of the leading causes of mortality and morbidity in chickens. There are numerous serotypes and variants, which do not confer cross protection resulting in failure of currently used IBV vaccines. Although variant IBV isolates with major genetic differences have been subjected to comparative studies, it is unknown whether minor genetic differences in IBV variants within a serotype are different in terms of pathogenesis and eliciting host responses. Read More

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December 2018

Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens.

PLoS One 2018 6;13(12):e0207611. Epub 2018 Dec 6.

Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Infectious laryngotracheitis (ILT) is an upper respiratory tract disease of chickens that is caused by infectious laryngotracheitis virus (ILTV), an alphaherpesvirus. This disease causes significant economic loses in poultry industries worldwide. Despite widespread use of commercial live attenuated vaccines, many poultry industries continue to experience outbreaks of disease caused by ILTV. Read More

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December 2018
1 Read

Evaluation of magnesium alloys for use as an intraluminal tracheal for pediatric applications in a rat tracheal bypass model.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261.

Tracheal stenting currently using non-degradable stents is commonplace for treatment of trauma, prolonged intubation related adult airway obstructions, and pediatric patients-associated tracheal stenosis conditions. Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. Read More

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December 2018
2 Reads

Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Lung Inflammatory Diseases Research Center, Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran.

The present study aimed to investigate the role of microRNA-146a and its adapter proteins [interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)-sensitized rats in association with the diet-induced obesity condition. Twenty male Wistar rats were divided into four groups: control with normal diet (ND), OVA-sensitized with normal diet (S + ND), high-fat diet (HFD), and OVA-sensitized with high-fat diet (S + HFD). All the animals were fed for 8 weeks with standard pelts or high-fat diet, and were then sensitized and challenged with OVA or saline for another 4 weeks. Read More

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December 2018
3 Reads

Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas.

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

The present study investigated the co-localization of the Middle East respiratory syndrome coronavirus (MERS-CoV) and its receptor dipeptidyl peptidase-4 (DPP4) across respiratory and lymphoid organs of experimentally MERS-CoV infected pigs and llamas by immunohistochemistry (IHC). Also, scanning electron microscopy (SEM) was performed to assess the ciliary integrity of respiratory epithelial cells in both species. In pigs, on day 2 post-inoculation (p. Read More

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December 2018

Oxygen reserve index (ORi™) contributes to prediction of hypoxemia and patient safety during tracheal stent insertion using rigid bronchoscopy: a case report.

J Clin Monit Comput 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi-Ken, 329-0498, Japan.

The oxygen reserve index (ORi™) is a new noninvasive and continuous variable, which represents a moderate hyperoxygenation status, with a unitless scale between 0.00 and 1.00. Read More

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December 2018

Mindray 3-directional NMT Module (a new generation "Tri-axial" neuromuscular monitor) versus the Relaxometer mechanomyograph and versus the TOF-Watch SX acceleromyograph.

J Clin Monit Comput 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Pharmacometrics, Centre for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Recently introduced Mindray "3-directional" neuromuscular transmission transducer (NMT, Shenzhen, China) acceleromyograph) claim to monitor thumb movement in 3 different directions. We compared NMT with the gold standard Relaxometer® mechanomyograph (MMG, Groningen University, Netherlands) in Study-1 and with TOF-Watch SX™ (WTCH) acceleromyograph from which it was developed in Study-2. We used first twitch (T%) and train-of-four (TOF) ratio rocuronium 0. Read More

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December 2018

Effects of fascia iliaca compartment block combined with general laryngeal mask airway anesthesia in children undergoing femoral fracture surgery: a randomized trial.

J Pain Res 2018 8;11:2821-2826. Epub 2018 Nov 8.

School of Medicine, Jiaxing University, Jiaxing 314000, Zhejiang, China,

Background: Postoperative agitation after general anesthesia is a common complication in children; however, pain or uncomfortable feeling is the main reason of emergence agitation. Here, we have investigated the effects of fascia iliaca compartment block (FICB) combined with general laryngeal mask airway (LMA) anesthesia in children undergoing femoral surgery.

Methods: Eighty children undergoing femoral surgery were randomly divided into two groups: FICB + LMA group and control group (n=40). Read More

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November 2018
1 Read

Aortopexy for tracheomalacia via a suprasternal incision.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Paediatric Surgery, Evelina London Children's Hospital, Lambeth, London, UK. Electronic address:

Aim: Tracheomalacia is flaccidity of the tracheal wall leading to tracheal collapse, particularly on expiration. When severe it can warrant surgical intervention. Aortopexy is one surgical option and has been described using a variety of approaches. Read More

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November 2018
1 Read

Effect of Kaempferol on Cyclooxygenase 2 (Cox2) and Cytosolic Phospholipase A2 (cPLA2) Protein Expression in BALB/c Mice.

Iran J Allergy Asthma Immunol 2018 Oct 14;17(5):428-435. Epub 2018 Oct 14.

Department of Animal Biotechnology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, Republic of Korea.

Kaempferol, a phytochemical found in many edible plants, is known to alleviate diseases such as cancer, allergy, and inflammation. The objective of this study was to investigate whether kaempferol could reduce omega-6 and ovalbumin-mediated allergic reactions at lung and trachea in BALB/c mice. Mice were allocated into five groups: 1) control group (CON); 2) positive control group with orally administration of omega-6 (POS); 3) bovine serum albumin (BSA) sensitization group (with BSA injection and ovalbumin inhalation); 4) BSA+K10 group: BSA injection, 10 μg/g of kaempferol administration and ovalbumin inhalation; and 5) BSA+K20 group: BSA injection, 20 μg/g of kaempferol administration and ovalbumin inhalation. Read More

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October 2018

Host immune responses of pigeons infected with Newcastle disease viruses isolated from pigeons.

Microb Pathog 2018 Nov 30;127:131-137. Epub 2018 Nov 30.

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, China; Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, China. Electronic address:

Newcastle disease (ND), affecting over 250 bird species, is caused by the Newcastle disease virus (NDV). ND is one of the leading causes of morbidity and mortality in pigeons. Most studies investigating NDV in pigeons have focused on the epidemiology and pathogenicity of the virus. Read More

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November 2018
4 Reads

HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.

Transpl Immunol 2018 Dec 1. Epub 2018 Dec 1.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.

Background: Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown.

Methods: A murine heterotopic tracheal transplantation model was used. Protein concentrations of HMGB1, interferon-γ (IFN-γ), interleukin (IL)-10, and IL-17 were analyzed in the isografts, allografts, controls, and HMGB1-neutralizing antibody administered allografts (n = 6; Days 1, 3, 5, 7, 14, 21, and 28). Read More

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December 2018
1 Read

Reconstruction of a Posterior Tracheal Wall Defect With a Myocutaneous Pectoralis Major Flap After Salvage Cervical Exenteration for a Squamous Carcinoma of the Upper Third of the Esophagus.

Plast Surg Nurs 2018 Oct/Dec;38(4):162-165

Enrique Salmerón-González, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Elena García-Vilariño, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Pedro A. Antolin-Santamaria, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Alberto Sanchez-Garcia, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Alfonso A. Valverde-Navarro, PhD, Director, Department of Human Anatomy and Embryology, University of Valencia, Spain.

In this article, we describe the case of a 59-year-old patient suffering from a squamous cell carcinoma affecting the upper third of the esophagus, treated with a cervical exenteration with extended resection of the posterior wall of the trachea, which was reconstructed with a gastric tube transposition and a myocutaneous pectoralis major flap for coverage of the gastropharyngeal anastomosis and stabilization of the posterior tracheal wall. Also, a review of literature regarding posterior tracheal wall reconstruction is performed. Read More

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December 2018
4 Reads

Nursing Considerations When Using Neuromuscular Blocking Agents to Assist With Intubation: A Review of Literature.

Crit Care Nurs Q 2019 Jan/Mar;42(1):30-40

Department of Baccalaureate Nursing, Indiana State University, Monroeville (Mr Blauvelt); and School of Nursing, Indiana State University, Terre Haute (Drs Burdick and Cannon).

The use of neuromuscular blocking agents (NMBAs) in acute care settings during intubation is vitally important. The NMBAs increase first pass success rates significantly while protecting patients from gastric aspiration, tracheal injury, and death. During emergent intubations, succinylcholine and rocuronium are commonly used, but each comes with specific risks and individualized interventions. Read More

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December 2018
1 Read

Impact of stainless-steel welding fumes on proteins and non-coding RNAs regulating DNA damage response in the respiratory tract of Sprague-Dawley rats.

J Toxicol Environ Health A 2018 Dec 3:1-15. Epub 2018 Dec 3.

a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , TN , India.

Substantial evidence has established the negative impact of inhalation exposure to welding fumes on respiratory functions. The aim of the present study was to investigate the effect of welding fume inhalation on expression of molecules that function as sensors, transducers and effectors of DNA damage response (DDR) in the respiratory tract of male Sprague-Dawley rats. Animals were exposed to 50 mg/m stainless steel welding fumes for 1 h/d for 4, 8, and 12 weeks, respectively. Read More

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December 2018
1 Read

Nursing Oral Suction Intervention to Reduce Aspiration and Ventilator Events (NO-ASPIRATE): A Randomized Clinical Trial.

J Adv Nurs 2018 Dec 3. Epub 2018 Dec 3.

Orlando Health, Orlando, FL.

Aim: The primary aim of this study is to compare an oropharyngeal suction intervention versus usual care on microaspiration in intubated patients. Secondary aims are to evaluate the intervention on ventilator associated condition rates, time to occurrence and compare tracheal-oral α-amylase ratios between groups.

Design: Prospective randomized clinical trial. Read More

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December 2018

Unintentional endotracheal tube cuff deflation during routine checks: a simulation study.

Nurs Crit Care 2018 Dec 2. Epub 2018 Dec 2.

The Critical Care Department, The Queen Elizabeth Hospital, King's Lynn, UK.

Background: Endotracheal tube cuff pressures should be maintained between 20 and 30 cm H O to prevent the aspiration of subglottic secretions past the cuff. Guidance recommends regular monitoring of the cuff pressure, performed using a handheld manometer/inflator. Poor technique can lead to transient deflation of the cuff, leading to the bolus aspiration of upper respiratory tract secretions, tracheal colonization and, ultimately, ventilator-associated pneumonia. Read More

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December 2018
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Preliminary study on application of augmented reality visualization in robotic thyroid surgery.

Ann Surg Treat Res 2018 Dec 26;95(6):297-302. Epub 2018 Nov 26.

Department of Biomedical Engineering, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Increased robotic surgery is attended by increased reports of complications, largely due to limited operative view and lack of tactile sense. These kinds of obstacles, which seldom occur in open surgery, are challenging for beginner surgeons. To enhance robotic surgery safety, we created an augmented reality (AR) model of the organs around the thyroid glands, and tested the AR model applicability in robotic thyroidectomy. Read More

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December 2018
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Haemodynamic Response to Four Different Laryngoscopes.

Turk J Anaesthesiol Reanim 2018 Dec 6;46(6):434-440. Epub 2018 Sep 6.

Department of Anaesthesiology and Reanimation, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.

Objective: In this prospective randomized study, we aimed to evaluate the effect of tracheal intubation with four different laryngoscopes [Macintosh direct laryngoscope-classic laryngoscope (CL), McCoy (MC), C-Mac video-laryngoscope (CM) and McGrath video-laryngoscope (MG)] on haemodynamic responses in patients with a normal airway.

Methods: One hundred and sixty patients were included. Succeeding haemodynamic measurements were performed immediately after intubation (T2) and for 5 min with 1-min intervals (T3-T4-T5-T6-T7). Read More

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December 2018
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Polypoidal trachea- A clinician's predicament.

Am J Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology & Head and Neck surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

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November 2018
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The effect of erdosteine on airway defence mechanisms and inflammatory cytokines in the settings of allergic inflammation.

Pulm Pharmacol Ther 2018 Nov 28. Epub 2018 Nov 28.

Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Pharmacology, Martin, Slovakia.

Introduction: Mucoactive agent, erdosteine, besides mucolytic activity, is characterized by many other pharmacodynamic properties which could be beneficial in the management of inflammatory conditions.

Background: s: Using guinea pig experimental model of allergic inflammation, we evaluated the ability of erdosteine to modulate airway defence mechanisms and inflammation after 10 days (10 mg/kg/day) administration.

Methods: In vivo changes in specific airway resistance and amplitude of tracheal contraction were estimated to evaluate the bronchodilatory effect. Read More

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November 2018
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Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.

J Mol Cell Cardiol 2018 Nov 28;127:20-30. Epub 2018 Nov 28.

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, NY, New York, USA. Electronic address:

Background: Pulmonary arterial hypertension (PAH) results in right ventricular (RV) failure, electro-mechanical dysfunction and heightened risk of sudden cardiac death (SCD), although exact mechanisms and predisposing factors remain unclear. Because impaired chronotropic response to exercise is a strong predictor of early mortality in patients with PAH, we hypothesized that progressive elevation in heart rate can unmask ventricular tachyarrhythmias (VT) in a rodent model of monocrotaline (MCT)-induced PAH. We further hypothesized that intra-tracheal gene delivery of aerosolized AAV1. Read More

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November 2018
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