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    1 OF 19

    Analysis of Intensive Care Unit Admission and Sequelae in Patients Intravenously Abusing Extended-Release Oral Oxymorphone.
    South Med J 2017 Mar;110(3):217-222
    From the Departments of Internal Medicine and Anesthesiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
    Objectives: Prescription drug abuse is a major public health problem in the United States, with the rate of opioid-related deaths nearly quadrupling between 2000 and 2014. Extended-release oral oxymorphone hydrochloride (Opana ER) is a long-acting opioid prescribed for chronic pain; however, it also has the potential to be abused via intravenous injection. This retrospective review sought to analyze specific complications and sequelae requiring intensive care unit resources for patients intravenously abusing extended-release oral oxymorphone. Read More

    Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery.
    Ann Card Anaesth 2017 Jan-Mar;20(1):45-51
    Cardiovascular Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: This study aimed to test the beneficial effect of grape seed extract (GSE) (Vitis vinifera) and Vitamin C in oxidative stress and reperfusion injury induced by cardiopulmonary bypass (CPB) in coronary artery bypass surgery.

    Patients And Methods: In this randomized trial, 87 patients undergoing elective and isolated coronary bypass surgery included. The patients were randomly assigned into three groups (n = 29 each): (1) Control group with no treatment, (2) GSE group who received the extract 24 h before operation, 100 mg every 6 h, orally, (3) Vitamin C group who received 25 mg/kg Vitamin C through CPB during surgery. Read More

    Ketorolac Tromethamine Spray Prevents Postendotracheal-Intubation-Induced Sore Throat after General Anesthesia.
    Biomed Res Int 2016 29;2016:4582439. Epub 2016 Nov 29.
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Rheumatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Nursing, College of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
    Background. Postoperative sore throat is one of the major complaints of general anesthesia in the postanesthesia care unit. This prospective study investigated the preventive effect of ketorolac tromethamine spray in postendotracheal-intubation-induced sore throat after general anesthesia. Read More

    Accuracy of rapid sequence intubation medication dosing in obese patients intubated in the ED.
    Am J Emerg Med 2016 Dec 28;34(12):2423-2425. Epub 2016 Sep 28.
    Department of Emergency Medicine, MedStar Washington Hospital Center, Washington, DC; Department of Emergency Medicine, Georgetown University School of Medicine, Washington, DC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, MedStar Washington Hospital Center, Washington, DC.
    Objective: There are limited data regarding appropriateness of sedative and paralytic dosing of obese patients undergoing rapid sequence intubation (RSI) in the emergency department. The goal of this study was to compare rates of appropriate succinylcholine and etomidate doses in obese and nonobese patients.

    Methods: Retrospective review using a database of endotracheally intubated patients using RSI in an urban, tertiary care academic emergency department, from November 2009 to June 2011. Read More

    Intubation of Profoundly Agitated Patients Treated with Prehospital Ketamine.
    Prehosp Disaster Med 2016 Dec 19;31(6):593-602. Epub 2016 Sep 19.
    2Department of Emergency Medicine,Hennepin County Medical Center,Minneapolis,MinnesotaUSA.
    Background: Profound agitation in the prehospital setting confers substantial risk to patients and providers. Optimal chemical sedation in this setting remains unclear.

    Objective: The goal of this study was to describe intubation rates among profoundly agitated patients treated with prehospital ketamine and to characterize clinically significant outcomes of a prehospital ketamine protocol. Read More

    Resuscitation Prior to Emergency Endotracheal Intubation: Results of a National Survey.
    West J Emerg Med 2016 Sep 26;17(5):542-8. Epub 2016 Jul 26.
    Trauma Nova Scotia, Halifax, Nova Scotia, Canada.
    Introduction: Respiratory failure is a common problem in emergency medicine (EM) and critical care medicine (CCM). However, little is known about the resuscitation of critically ill patients prior to emergency endotracheal intubation (EETI). Our aim was to describe the resuscitation practices of EM and CCM physicians prior to EETI. Read More

    Geriatric Resuscitation.
    Emerg Med Clin North Am 2016 Aug;34(3):453-67
    Emergency Medicine, Montefiore/Jacobi Medical Centers, 1400 Pelham Parkway South, Bronx, NY 10461, USA.
    The geriatric population makes up a large portion of the emergency patient population. Geriatric patients have less reserve and more comorbid diseases. They are frequently on multiple medications and are more likely to require aggressive treatment during acute illness. Read More

    The Effect of Betamethasone Gel and Lidocaine Jelly Applied Over Tracheal Tube Cuff on Postoperative Sore Throat, Cough, and Hoarseness.
    J Perianesth Nurs 2016 Aug 17;31(4):298-302. Epub 2016 May 17.
    Purpose: The purpose of the study was to investigate the effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the postextubation syndrome incidence (sore throat, cough, and hoarseness).

    Design: Double-blind randomized clinical trial study was used.

    Methods: Ninety-nine patients of either sex undergoing elective surgery, under general anesthesia with endotracheal intubation, were recruited. Read More

    Statin Medication Use and Nosocomial Infection Risk in the Acute Phase of Stroke.
    J Stroke Cerebrovasc Dis 2016 Oct 9;25(10):2360-7. Epub 2016 Jun 9.
    Providence Sacred Heart Medical Center, Spokane, Washington; Department of Pharmacotherapy, College of Pharmacy, Washington State University, Spokane, Washington.
    Goal: Statins have immunomodulatory and peripheral anti-inflammatory properties that are independent of their lipid-lowering action. Whether these properties reduce the risk for developing poststroke infection is debated in clinical literature. We estimated the risk for developing nosocomial poststroke infection based on statin exposure in patients aged 18 or older hospitalized for ischemic stroke. Read More

    Sustained release of isoniazid from polylactide microspheres prepared using solid/oil drug loading method for tuberculosis treatment.
    Sci China Life Sci 2016 Jul 8;59(7):724-31. Epub 2016 Jun 8.
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China.
    Polylactide (PLA) microspheres were prepared using the solid-in-oil (S/O) spray-drying method to achieve the sustained release of a hydrophilic drug for the treatment of tuberculosis, via intratracheal instillation. Isoniazid (IN), a low-molecular-weight hydrophilic drug, was used as a model drug. The effects of various sizes of micronized IN powder, different drug/polymer ratios, spray-drying process parameters, and drug-release characteristics were studied to optimize the manufacturing parameters. Read More

    Variation in seizure prophylaxis in severe pediatric traumatic brain injury.
    J Neurosurg Pediatr 2016 Oct 3;18(4):499-506. Epub 2016 Jun 3.
    Neurological Surgery.
    OBJECTIVE Posttraumatic seizure is a major complication following traumatic brain injury (TBI). The aim of this study was to determine the variation in seizure prophylaxis in select pediatric trauma centers. The authors hypothesized that there would be wide variation in seizure prophylaxis selection and use, within and between pediatric trauma centers. Read More

    Comparative study between benzydamine hydrochloride gel, lidocaine 5% gel and lidocaine 10% spray on endotracheal tube cuff as regards postoperative sore throat.
    Braz J Anesthesiol 2016 May-Jun;66(3):242-8. Epub 2014 Nov 26.
    Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
    Postoperative sore throat is a common complication after endotracheal intubation. After tracheal intubation, the incidence of sore throat varies from 14.4% to 50%. Read More

    Outcomes of Patients with Alcohol Withdrawal Syndrome Treated with High-Dose Sedatives and Deferred Intubation.
    Ann Am Thorac Soc 2016 Feb;13(2):248-52
    2 Hospital of Central Connecticut, New Britain, Connecticut.
    Rationale: High doses of sedating drugs are often used to manage critically ill patients with alcohol withdrawal syndrome.

    Objectives: To describe outcomes and risks for pneumonia and endotracheal intubation in patients with alcohol withdrawal syndrome treated with high-dose intravenous sedatives and deferred endotracheal intubation.

    Methods: Observational cohort study of consecutive patients treated in the intensive care unit (ICU) of a university-affiliated, community hospital for alcohol withdrawal syndrome, where patients were not routinely intubated to receive high-dose or continuously infused sedating medications. Read More

    Attenuation of Hemodynamic Responses to Intubation by Gabapentin in Coronary Artery Bypass Surgery: a Randomized Clinical Trial.
    Acta Med Iran 2015 Dec;53(12):733-7
    Department of Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    A varieties of medications have been suggested to prevent hemodynamic instabilities following laryngoscopy and endotracheal intubation. This study was conducted to determine the beneficial effects of gabapentin on preventing hemodynamic instabilities associated with intubation in patients who were a candidate for coronary artery bypass surgery (CABG). This double blinded randomized, parallel group clinical trial was carried out on 58 normotensive patients scheduled for elective CABG under general anesthesia with endotracheal intubation in Shariati Hospital. Read More

    Epidural pain relief versus systemic opioid-based pain relief for abdominal aortic surgery.
    Cochrane Database Syst Rev 2016 Jan 5(1):CD005059. Epub 2016 Jan 5.
    Department of Anesthesiology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada.
    Background: Epidural analgesia offers greater pain relief compared to systemic opioid-based medications, but its effect on morbidity and mortality is unclear. This review was originally published in 2006 and was updated in 2012 and again in 2016.

    Objectives: To assess the benefits and harms of postoperative epidural analgesia in comparison with postoperative systemic opioid-based analgesia for adults undergoing elective abdominal aortic surgery. Read More

    Differential Medical Aerosol Device and Interface Selection in Patients during Spontaneous, Conventional Mechanical and Noninvasive Ventilation.
    J Aerosol Med Pulm Drug Deliv 2016 Apr 30;29(2):95-106. Epub 2015 Dec 30.
    Division of Respiratory Therapy, Georgia State University , Atlanta, Georgia .
    Many aerosol delivery devices are available on the market that have different features, characteristics, and operating requirements that need to be considered for the effective treatment of patients with pulmonary diseases. Device selection in aerosol medicine is largely patient dependent. Since there is no aerosol device that suits all patient populations, device selection and successful integration of the prescribed aerosol device to patients is essential. Read More

    Hemodynamic changes with high infusion rates of lipid emulsion. Experimental study in swine.
    Acta Cir Bras 2015 Nov;30(11):720-6
    UNICAMP, Campinas, SP, Brazil.
    Purpose: To evaluate hemodynamic changes caused by sole intravenous infusion of lipid emulsion with doses recommended for treatment of drug-related toxicity.

    Methods: Large White pigs underwent general anesthesia, tracheal intubation was performed, and mechanical ventilation was instituted. Hemodynamic variables were recorded using invasive blood pressure and pulmonary artery catheterization. Read More

    Reducing sore throat following laryngeal mask airway insertion: comparing lidocaine gel, saline, and washing mouth with the control group.
    Braz J Anesthesiol 2015 Nov-Dec;65(6):450-4. Epub 2013 Oct 26.
    Social Medicine Department, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
    Background: Laryngeal mask airway is still accompanied by complications such as sore throat. In this study, effects of three methods of reducing postoperative sore throat were compared with the control group.

    Methods: 240 patients with ASA I, II candidates for cataract surgery were randomly divided into four same groups. Read More

    Fluid flow and particle transport in mechanically ventilated airways. Part II: particle transport.
    Med Biol Eng Comput 2016 Jul 5;54(7):1097-109. Epub 2015 Nov 5.
    Respiratory and Critical Care Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA.
    The flow mechanisms that play a role on aerosol deposition were identified and presented in a companion paper (Timothy et al. in Med Biol Eng Comput. doi: 10. Read More

    Post-intubation tracheal stenosis after management of complicated aortic dissection: a case series.
    J Cardiothorac Surg 2015 Nov 4;10:148. Epub 2015 Nov 4.
    Department of Anesthesia, First hospital of Jilin University, No.71st Xinmin ST, Changchun, Jilin, 130021, China.
    Background: Patients undergoing total aortic arch replacement or aortic dissecting aneurysmectomy are generally managed with medications to control hypotension and blood coagulation to minimize mortality and morbidity. However, prolonged mechanical ventilation via tracheal intubation increases the risk of tracheal stenosis in such patients.

    Case Presentation: We present 2 cases (a 49-year-old woman and a 62-year-old man) of post-intubation tracheal stenosis occurring after surgery for the correction of complicated aortic dissection; both cases were successfully managed by tracheal cryotherapy. Read More

    [The Interaction of Low-dose Droperidol, Propofol, and Sevoflurane on QTc Prolongation].
    Masui 2015 Jun;64(6):580-5
    Background: Droperidol is an effective antiemetic, but its use is limited because of the warning of drug-induced QT prolongation. Some reports showed that low-dose droperidol does not significantly probing QT interval. This study was aimed to determine the effect of low-dose droperidol (1. Read More

    [Two Separate Instances of Anesthetic Management in a Patient Initially Diagnosed with Stiff-person Syndrome].
    Masui 2015 Apr;64(4):430-3
    In this case report, we describe separate instances of general anesthetic management administered to a patient during treatment for two unrelated conditions. The patient, a 57-year-old woman who had been experiencing walking difficulties for about four years, fell down because of muscle rigidity and spasms and fractured her humerus. She was subsequently diagnosed with stiff-person syndrome. Read More

    Intubation of the Neurologically Injured Patient.
    J Emerg Med 2015 Dec 26;49(6):920-7. Epub 2015 Sep 26.
    University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Intubation of the neurologically injured patient is a critical procedure that must be done in a manner to prevent further neurologic injury. Although many different medications and techniques have been used to meet specific needs, there is little to no evidence to support many claims.

    Objective: To review the literature regarding important topics relating to intubating patients with neurologic injury. Read More

    THE BARIATRIC AIRWAY. It's not all about the intubation.
    JEMS 2015 Aug;40(8):58-60
    In airway procedures, preparation is 90% of success. For obese patients, positioning is 90% of this preparation. Other considerations include utilizing NIPPV and nasal cannula apneic oxygenation, utilizing multiple providers and airway adjuncts for BVM ventilation, correctly dosing medications based upon ideal, lean or total body weight, and having backup airway devices ready. Read More

    Comparison of Second-Generation Supraglottic Airway Devices (i-gel versus LMA ProSeal) During Elective Surgery in Children.
    AANA J 2015 Aug;83(4):275-80
    Second-generation supraglottic airway devices i-gel (Intersurgical Ltd) and LMA ProSeal (Teleflex Inc) are designed for a superior airway seal with a high success rate in adults. This study compared the efficacy of i-gel and LMA ProSeal (sizes 1, 1.5, and 2) as an airway device in a pediatric population, especially infants. Read More

    Anesthetic management of pediatric patients with Sturge-Weber syndrome: our experience and a review of the literature.
    J Anesth 2015 Dec 21;29(6):857-61. Epub 2015 Jul 21.
    Department of Anesthesia and Intensive Care, AIIMS, New Delhi, India.
    Introduction: Sturge-Weber syndrome (SWS) is a rare sporadic congenital neurocutaneous syndrome which is characterized by vascular malformation involving the brain, face and eye. The anesthetic management is complicated by its localized as well as systemic manifestations, associated anomalies and difficult airway due to the presence of angiomas of the oral cavity and airway. We retrospective analyzed the perioperative anesthetic management of children with SWS undergoing ophthalmic surgery and reviewed the literature. Read More

    [Anesthetic Management of Laparoscopic Nephrectomy for a Renal Cancer Patient with Distal Myopathy of Rimmed Vacuole].
    Masui 2015 Feb;64(2):164-7
    A 56-year-old male with distal myopathy of rimmed vacuoles underwent laparoscopic nephrectomy. Anesthesia was induced with propofol, remifentanil and ketamine. Tracheal intubation using McGRATH was uneventful without using muscle relaxants. Read More

    [Use of the i-gel for Tracheostomy in a Patient with Neck Deformity and Tracheal Stenosis].
    Masui 2015 Mar;64(3):307-9
    We report a successful use of the i-gel for tracheostomy in a patient with severe neck deformity and tracheal stenosis. A 20-year-old man, 142 cm, 22 kg, was scheduled for tracheotomy. He had tracheal stenosis with hypoxemia, due to the pressure from the brachiocephalic artery, associated with severe progression of symptomatic scoliosis and thoracic deformity. Read More

    Retrospective evaluation of prognostic indicators in dogs with head trauma: 72 cases (January-March 2011).
    J Vet Emerg Crit Care (San Antonio) 2015 Sep-Oct;25(5):631-9. Epub 2015 Jun 25.
    Ontario Veterinary College Health  Sciences  Centre, University of Guelph, Guelph, Ontario, Canada.
    Objective: To investigate the prognostic value of clinical and laboratory variables and scoring systems in dogs with head trauma.

    Design: Retrospective study (January-March, 2011).

    Setting: University teaching hospital. Read More

    Hydrogel Antimicrobial Capture Coatings for Endotracheal Tubes: A Pharmaceutical Strategy Designed to Prevent Ventilator-Associated Pneumonia.
    Mol Pharm 2015 Aug 23;12(8):2928-36. Epub 2015 Jul 23.
    School of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom.
    This paper presents a novel strategy for the prevention of ventilator-associated pneumonia that involves coating poly(vinyl chloride, PVC) endotracheal tubes (ET) with hydrogels that may be subsequently used to entrap nebulized antimicrobial solutions. Candidate hydrogels were prepared containing a range of ratios of hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) from 100:0 to 70:30 using free radical polymerization and, when required, simultaneous attachment to PVC was performed. The mechanical properties, glass transition temperatures, swelling kinetics, uptake of gentamicin from an aqueous medium, and gentamicin release were characterized. Read More

    Effect-site concentration of remifentanil for attenuating QTc interval prolongation following intubation in hypertensive female patients.
    Acta Anaesthesiol Scand 2015 Nov 24;59(10):1269-77. Epub 2015 Jun 24.
    Department of Anaesthesiology and Pain Medicine, Severance Hospital, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Background: Haemodynamic changes after sympathetic stimuli like tracheal intubation are more pronounced in hypertensive patients than in normotensive patients. Heart rate (HR)-corrected QT (QTc) interval changes related to intubation may also be more prominent in hypertensive patients. We hypothesised that there would be a difference in the effect-site concentration (Ce) of remifentanil to attenuate QTc interval prolongation in normotensive and hypertensive patients following intubation. Read More

    Awake without complaints: maximizing comfort during awake fiberoptic intubation.
    J Clin Anesth 2015 Sep 18;27(6):517-9. Epub 2015 Jun 18.
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA. Electronic address:
    In obese patients with unfavorable airways, awake fiberoptic intubations are sometimes performed to maintain spontaneous respiration and airway reflexes, until a secure airway is attained. Obese patients may be sensitive to the effects of sedation. Rapid oxygen desaturation may occur as a result of brief moments of apnea from even minimal amounts of sedating medications, due to poor baseline functional reserve as well as common comorbid conditions such as obstructive sleep apnea and obesity hypoventilation syndrome. Read More

    Target-Controlled Infusion of Remifentanil Without Muscle Relaxants Allows Acceptable Surgical Conditions During Thoracotomy Performed Under Sevoflurane Anesthesia.
    J Cardiothorac Vasc Anesth 2015 Dec 7;29(6):1557-66. Epub 2015 Feb 7.
    Surgery, King Fahd Hospital of the University of Dammam, Dammam, Saudi Arabia.
    Objectives: To test the hypothesis that the use of a nonmuscle relaxant anesthetic technique (NMRT) during thoracotomy would be associated with comparable surgical conditions with the standard use of neuromuscular blocking drugs.

    Design: A prospective, randomized, single-blind, controlled study.

    Setting: A single university hospital. Read More

    Factors Associated with Adverse Events during Tracheal Intubation in the NICU.
    Neonatology 2015 6;108(1):23-9. Epub 2015 May 6.
    Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pa., USA.
    Background: The incidence of adverse tracheal intubation-associated events (TIAEs) and associated patient, practice, and intubator characteristics in the neonatal intensive care unit (NICU) setting are unknown.

    Objectives: To determine the incidence of adverse TIAEs and to identify factors associated with TIAEs in the NICU.

    Methods: Single-site prospective observational cohort study of infants who were intubated in a level 4 referral NICU between September 1, 2011 and November 30, 2013. Read More

    Pulmonary Delivery of Vancomycin Dry Powder Aerosol to Intubated Rabbits.
    Mol Pharm 2015 Aug 6;12(8):2665-74. Epub 2015 May 6.
    †Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, United States.
    Antibiotic multiresistant pneumonia is a risk associated with long-term mechanical ventilation. Vancomycin is commonly prescribed for methicillin-resistant Staphylococcus aureus infections; however, current formulations of vancomycin are only given intravenously. High doses of vancomycin have been associated with severe renal toxicity. Read More

    EMS Intubation Improves with King Vision Video Laryngoscopy.
    Prehosp Emerg Care 2015 24;19(4):482-9. Epub 2015 Apr 24.
    Introduction: Intubation success by paramedics has historically been variable. The lack of first-pass success (FPS) has been associated with increased adverse events. Various video laryngoscope (VL) devices have been investigated to improve success among paramedics. Read More

    Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial.
    Trials 2015 Apr 21;16:177. Epub 2015 Apr 21.
    Department of Critical Care Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA, 17822, USA.
    Background: Endotracheal intubation (ETI) is commonly performed as a life-saving procedure in the intensive care unit (ICU). It is often associated with significant hemodynamic perturbations and can severely impact the outcome of ICU patients. Etomidate is often chosen by many critical care providers for the patients who are hypotensive because of its superior hemodynamic profile compared to other induction medications. Read More

    Severity of disease estimation and risk-adjustment for comparison of outcomes in mechanically ventilated patients using electronic routine care data.
    Infect Control Hosp Epidemiol 2015 Jul 17;36(7):807-15. Epub 2015 Apr 17.
    1Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,Massachusetts.
    BACKGROUND Valid comparison between hospitals for benchmarking or pay-for-performance incentives requires accurate correction for underlying disease severity (case-mix). However, existing models are either very simplistic or require extensive manual data collection. OBJECTIVE To develop a disease severity prediction model based solely on data routinely available in electronic health records for risk-adjustment in mechanically ventilated patients. Read More

    Prophylactic potential of defensins and L-isoleucine in tuberculosis household contacts: an experimental model.
    Immunotherapy 2015 ;7(3):207-13
    Unidad de Investigación Médica-Zacatecas, Mexican Institute for Social Security, México.
    Aim: Patients with pulmonary tuberculosis (TB) are the most important source for TB infection, being the risk of infection determined by the source case infectiousness and the contact closeness. Currently, the administration of isoniazid is used to prevent the infection to some extent in household contacts. At experimental level, defensins are efficient molecules for the treatment of TB and other infectious diseases. Read More

    Performance of size 1 I-gel compared with size 1 ProSeal laryngeal mask in anesthetized infants and neonates.
    ScientificWorldJournal 2015 22;2015:426186. Epub 2015 Feb 22.
    Department of Anesthesiology and Reanimation, Inonu University Medical Faculty, B Blok Daire 11, Malatya, Turkey.
    Purpose: The size 1 I-gel, recommended for small infants and neonates weighing 2-5 kg, has recently been released. There are no prospective studies available that assess the insertion conditions, sealing pressures, or ventilation quality of it. This study was designed to compare the performance of recently released size 1 I-gel with size 1 ProSeal LMA. Read More

    Sedation options for intubated intensive care unit patients.
    Crit Care Nurs Clin North Am 2015 Mar;27(1):131-45
    Department of Anesthesiology, Yale-New Haven Hospital, 20 York Street, New Haven, CT 06510, USA. Electronic address:
    A common requirement for intubated patients in the intensive care unit (ICU) is sedation and pain management to facilitate patient safety and timely, atraumatic healing. The Society of Critical Care Medicine guidelines for management of pain, sedation, and delirium in adult ICU patients provide assessment scales for pain, sedation, and delirium; medications for sedation and pain management, and protocols for weaning sedation, are discussed. Proficient assessment skills, pharmacologic knowledge of medications administered to provide sedation, and an understanding of the importance of nonpharmacologic interventions can help the registered nurse provide patient advocacy, safety, and improved outcomes. Read More

    Hemodynamic changes with two lipid emulsions for treatment of bupivacaine toxicity in swines.
    Acta Cir Bras 2015 Feb;30(2):87-93
    Hospital, UNICAMP, Campinas, SP, Brazil.
    Purpose: To compare the hemodynamic changes following two different lipid emulsion therapies after bupivacaine intoxication in swines.

    Methods: Large White pigs were anesthetized with thiopental, tracheal intubation performed and mechanical ventilation instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). Read More

    Ketamine and propofol combination ("ketofol") for endotracheal intubations in critically ill patients: a case series.
    Am J Case Rep 2015 Feb 13;16:81-6. Epub 2015 Feb 13.
    Department of Anesthesiology, Division of Critical Care Medicine and Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, MN, USA.
    Background: Endotracheal intubation is a common procedure performed for critically ill patients that can have immediate life-threatening complications. Induction medications are routinely given to facilitate the procedure, but most of these medications are associated with hypotension. While etomidate is known for its neutral hemodynamic profile, it has been linked with increased mortality in septic patients and increased morbidity in trauma patients. Read More

    Intravenous fluids in acute decompensated heart failure.
    JACC Heart Fail 2015 Feb;3(2):127-33
    Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut; Robert Wood Johnson Foundation Clinical Scholars Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut. Electronic address:
    Objectives: This study sought to determine the use of intravenous fluids in the early care of patients with acute decompensated heart failure (HF) who are treated with loop diuretics.

    Background: Intravenous fluids are routinely provided to many hospitalized patients.

    Methods: We conducted a retrospective cohort study of patients admitted with HF to 346 hospitals from 2009 to 2010. Read More

    Preeclampsia: an update.
    Acta Anaesthesiol Belg 2014 ;65(4):137-49
    Preeclampsia was formerly defined as a multisystemic disorder characterized by new onset of hypertension (i.e. systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg) and proteinuria (> 300 mg/24 h) arising after 20 weeks of gestation in a previously normotensive woman. Read More

    Does prewarming the i-gel supraglottic airway device fit the larynx better compared to keeping it at room temperature for non-paralysed, sedated patients: a randomised controlled trial.
    BMJ Open 2015 Jan 13;5(1):e006653. Epub 2015 Jan 13.
    Department of Anaesthesiology, Osaka Medical College, Takatsuki, Osaka, Japan.
    Objective: This study aimed to test the hypothesis that the i-gel supraglottic airway device would fit the larynx and provide better sealing pressure if prewarmed to 42°C relative to the device kept at room temperature in non-paralysed, sedated patients.

    Methods: A total of 74 adult patients were assigned to the warm (i-gel prewarmed to 42°C; W group; 37 patients) or the control (i-gel kept at room temperature; C group; 37 patients) groups. Anaesthesia was induced with propofol and fentanyl. Read More

    Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study.
    Pediatr Crit Care Med 2015 Mar;16(3):210-8
    1Department of Pediatrics, Pediatric Critical Care Medicine, Hasbro Children's Hospital, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI. 2Department of Pediatrics, Weill Cornell Medical College, New York, NY. 3Pediatric Critical Care Medicine, University of Louisville, Louisville, KY. 4Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke Children's Hospital, Duke University Medical Center, Durham, NC. 5Department of Pediatrics, Pediatric Critical Care Medicine, Stony Brook University School of Medicine, Stony Brook, NY. 6Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 7Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
    Objectives: Tracheal intubation in PICUs is often associated with adverse tracheal intubation-associated events. There is a paucity of data regarding medication selection for safe tracheal intubations in PICUs. Our primary objective was to evaluate the association of medication selection on specific tracheal intubation-associated events across PICUs. Read More

    Airborne transmission and precautions: facts and myths.
    J Hosp Infect 2015 Apr 13;89(4):225-8. Epub 2014 Dec 13.
    University of Hong Kong, School of Public Health, Hong Kong, SAR, China. Electronic address:
    Airborne transmission occurs only when infectious particles of <5 μm, known as aerosols, are propelled into the air. The prevention of such transmission is expensive, requiring N95 respirators and negative pressure isolation rooms. This lecture first discussed whether respiratory viral infections are airborne with reference to published reviews of studies before 2008, comparative trials of surgical masks and N95 respirators, and relevant new experimental studies. Read More

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