Search Our Scientific Publications & Authors

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Division of Thoracic Surgery, Thoracic Surgery Research Laboratory (LIM-61), Heart Institute (InCor) do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Rua Dr. Eneas de Carvalho Aguiar 44, Bloco I, 7° andar, São Paulo, SP, 05403-000, Brazil.

To evaluate the feasibility of a 980-nm contact diode laser (CDL) as a method for creating a posterior laryngofissure in live pigs. Twenty-eight Landrace pigs (15-20 kg) were anesthetized, intubated, ventilated, and submitted to a cervical tracheostomy. An anterior and posterior midline longitudinal laryngofissure incision was created according to randomization-control (n = 4), posterior laryngofissure with a scalpel blade; electrocautery (n = 12), posterior laryngofissure by electrocautery (10, 15, 20, 25 W powers); CDL (n = 12), posterior laryngofissure by the CDL (10, 15, 20, 25 W peak powers in pulsed mode). Read More

Thorac Cardiovasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatric Cardiac Surgery, Heart Hospital, G. Monasterio Foundation, Massa, Italy.

Background:  Left pulmonary artery (LPA) sling (PAS) is a vascular ring, which is frequently associated with long-segment tracheal stenosis (TS). Mortality rate in operated children is still high, especially in cases of severe tracheal hypoplasia and/or associated congenital heart defects (CHDs). We report our experience of treatment and follow-up in a pediatric cohort of patients affected by PAS with severe tracheobronchial involvement. Read More

Ann Thorac Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Thoracic Surgery, University of Perugia Medical School, Loc. Sant'Andrea delle Fratte, 06134, Perugia, Italy. Electronic address:

An innovative technique for airway management, utilizing a small diameter, short-cuffed, orotracheal tube for assisting rigid bronchoscopy in critical airway obstruction is reported. The device, part of Translaryngeal Tracheostomy KIT, was placed beyond the stenosis and used in combination with the rigid bronchoscope. This procedure improves safety during the management of critical tracheal stenoses, because the airway is constantly under the anesthesiologist's control. Read More

J Bras Pneumol 2018 Nov-Dec;44(6):486-490

. Departamento de Cirurgia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista - UNESP - Botucatu (SP) Brasil.

Objective: To evaluate the efficacy of mitomycin C (MMC) in the endoscopic treatment of tracheal stenosis.

Methods: Patients with laryngotracheal, tracheal, or tracheobronchial stenosis were treated with dilation and topical MMC. The inclusion criteria were as follows: being ineligible for surgery (for medical reasons) at the time of evaluation; membranous stenosis responding well to dilation; and postoperative stenosis at the anastomosis site. Read More

Birth Defects Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah.

Background: The mutant chondrodysplasia (cho) is a cartilage-targeting disorder in C57BL mice that results in dwarfing and other malformations stemming from this collagenopathy. Clarke Fraser made the discovery of the mutation accidentally in the early 1960s during the thalidomide tragedy.

Methods: For this review we identified key research on cho as since its discovery. Read More

Otolaryngol Head Neck Surg 2019 Feb 5:194599818825471. Epub 2019 Feb 5.

2 Surgical Outcomes Center for Kids, Vanderbilt University, Nashville, Tennessee, USA.

Objective: The primary aim of this study is to evaluate the safety, efficacy, and execution of major open laryngotracheal operations for patients in the advanced decades.

Study Design: Case series with chart review.

Setting: Multidisciplinary clinic at a tertiary care academic hospital. Read More

Eur J Cardiothorac Surg 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, Australia.

Objectives: Pulmonary artery (PA) sling is a rare vascular anomaly often associated with congenital tracheal stenosis. We describe the long-term outcomes with repair of this condition.

Methods: A retrospective study was conducted at 2 institutions. Read More

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Japan.

Pulmonary artery (PA) sling is a congenital disease in which the left PA abnormally arises from the right PA and is usually diagnosed during the infantile period. We present an adult case of PA sling accompanied by tracheobronchomalacia found in a 49-year-old woman with a history of recurrent pneumonia. Computed tomography of the chest showed that the left lung was nourished by two aberrant PAs. Read More

Thorax 2019 Feb 2. Epub 2019 Feb 2.

Department of Clinical Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Pneumologie 2019 Jan 31. Epub 2019 Jan 31.

Lungenklinik Köln-Merheim, Lehrstuhl für Thoraxchirurgie, Kliniken der Stadt Köln gGmbH, private Universität Witten/Herdecke, Köln.

Introduction:  Cervical stenosis of the trachea caused by tracheotomy, tumor or without defined reason (idiopathic) can be treated by resection and anastomosis with good early and long-term results. Involvement of the ring cartilage makes the procedure technically demanding and increases the risk of morbidity. We describe our technique of laryngotracheal resection and reconstruction and compare the perioperative results with standard tracheal resection. Read More

Ann Otol Rhinol Laryngol 2019 Jan 30:3489419826134. Epub 2019 Jan 30.

1 Center for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

Objectives:: The clinical experience with tissue-engineered tracheal grafts (TETGs) has been fraught with graft stenosis and delayed epithelialization. A mouse model of orthotopic replacement that recapitulates the clinical findings would facilitate the study of the cellular and molecular mechanisms underlying graft stenosis.

Methods:: Electrospun nanofiber tracheal scaffolds were created using nonresorbable (polyethylene terephthalate + polyurethane) and co-electrospun resorbable (polylactide-co-caprolactone/polyglycolic acid) polymers (n = 10/group). Read More

Rev Mal Respir 2019 Jan 25. Epub 2019 Jan 25.

Service de chirurgie thoracique, CHU Hassan II, BP. 1893, Km 2.200, route de Sidi Harazem, 30000 Fès, Maroc; Faculté de médecine et de pharmacie, université Sidi Mohamed Ben Abdellah, Fès, Maroc.

Introduction: Primary tumours of the trachea are very rare and may develop from the tracheal salivary glands.

Case Reports: We describe four patients operated on in our service between 2010 and 2017 of whom two had an adenocystic carcinoma, one a mucoepidermoid carcinoma and one a pleomorphic adenoma of the trachea. All were treated by resection and tracheal anastomosis with clear margins in three cases. Read More

Ann Otol Rhinol Laryngol 2019 Jan 28:3489419826601. Epub 2019 Jan 28.

1 Department of Otolaryngology-Head & Neck Surgery, The Ohio State University Medical Center, Columbus, OH, USA.

Objectives:: Laryngotracheal stenosis and obstruction can be challenging to manage. Traditional assessment tools are limited in clinical correlation. Three-dimensional computational fluid dynamics (CFD) modeling is a novel technique used to analyze airflow dynamics. Read More

Niger J Clin Pract 2019 Jan;22(1):134-137

Division of Cardiothoracic Surgery, National Cardiothoracic Center, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Postintubation tracheal stenosis (PITS) is a known complication of endotracheal intubation or tracheostomy. It is the most common indication for tracheal resection/reconstructive surgery. Despite technological improvement and skilled patient care in the ICU, PITS still constitutes an important group of iatrogenic sequela after intubation. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14169

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University.

We aimed to evaluate the safety and efficacy of combined airway and esophageal stents under fluoroscopy guidance and local anesthesia for patients with malignant tracheobronchial and esophageal disease. This retrospective analysis included 35 consecutive patients underwent combined stenting from March 2012 to August 2016. All patients underwent chest computed tomography scans before stenting and during follow-up. Read More

J Dent Anesth Pain Med 2018 Dec 28;18(6):375-378. Epub 2018 Dec 28.

Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Yangsan, Republic of Korea.

Endotracheal intubation is commonly associated with laryngeal injury that often resolves spontaneously without any complication. However, stenosis or granulomatous lesions are generally found on the tracheal wall or vocal process at the tube cuff level, caused by excessive cuff pressure. We present a case of fatal vocal cord granuloma leading to dyspnea following orthognathic surgery and sustained intubation for 14 hours. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Jan;54(1):23-28

Department of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

To discuss the surgical safeness of the cleft palate children with airway stenosis by means of analyzing characteristics of the shape of the upper airway and comparing clinical data of cleft palate children with airway stenosis and non-airway stenosis. Tracing back from Apirl 2015 to Apirl 2017, 126 cleft palate children treated in Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, were included (46 male and 80 female, age of 7 to 74 months, median age 18 months). According to the spiral CT scan of neck, patients were categorized to airway-stenosis group (65 patients) and non-airway-stenosis group (61 patients). Read More

Laryngoscope 2019 Jan 8. Epub 2019 Jan 8.

Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom.

Objective: Translational research into subglottic disease is restricted by the availability of primary human tissue originating from this subsite. Primary epithelial cells are also limited by their inability to survive beyond several divisions in culture outside of the body. Specific subglottic cell lines, useful for in vitro studies, have not yet been described. Read More

Front Pediatr 2018 18;6:401. Epub 2018 Dec 18.

Neonatal Surgery Unit, Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.

Presence of laryngotracheal abnormalities is associated with increased morbidity and higher mortality rate in esophageal atresia patients. Determine the prevalence of laryngotracheal abnormalities (LTA) in a prospectively collected cohort of patients treated for esophageal atresia and/or tracheoesophageal fistula (EA/TEF). Analysis of the impact of those airway anomalies in early post-operative outcomes was performed. Read More

Int J Artif Organs 2019 Jan 7:391398818819953. Epub 2019 Jan 7.

1 National Research Center for Maternal and Child Health, Astana, Kazakhstan.

Purpose:: For the first time in Kazakhstan, we have used a combined extracorporeal support, by including the CytoSorb system in a continuous veno-venous hemofiltration system in an 8-month-old patient with a body weight of 5600 g.

Results:: The CytoSorb therapy session resulted in a reduction of inflammation markers IL-6, S100, procalcitonin, and C-reactive protein. Simultaneously, the level of transaminases, creatine kinase, and troponin were normalized, by the end of the session patient hemodynamics were stable and there was no need for vasopressors, acid-base balance was maintained, and the patient was weaned from mechanical ventilation to spontaneous breathing. Read More

Ann Otol Rhinol Laryngol 2019 Jan 4:3489418820348. Epub 2019 Jan 4.

1 University Voice and Swallowing Center, Department of Otolaryngology-Head and Neck Surgery, UC Irvine School of Medicine, Irvine, California, USA.

Objective:: Idiopathic subglottic stenosis (iSGS) is a rare disease with few local resources for individuals to use. With the explosive growth of online social networking, platforms such as Facebook possess compelling potential to facilitate user-driven sharing of health information and peer support. This study was performed to better understand the content shared in a busy online community for individuals with iSGS. Read More

Thorac Cancer 2019 Feb 29;10(2):378-380. Epub 2018 Dec 29.

Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

Robotic surgery for circumferential tracheal resection and reconstruction has not previously been reported. Herein we describe the case of a 48-year-old man with primary extra-luminal tracheal leiomyosarcoma. A preoperative bronchoscopy exam and chest computed tomography revealed a tracheal neoplasm, which derived from lower membranous trachea and nearly obstructed the orifice of the left main bronchus. Read More

Laryngoscope 2018 Dec 28. Epub 2018 Dec 28.

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio, U.S.A.

Objectives: 1) Evaluate success rates for adults undergoing cervical slide tracheoplasty. 2) Examine complication rates of slide tracheoplasty in adults.

Methods: A retrospective cohort of adults > 21 years of age undergoing cervical slide tracheoplasty for tracheal stenosis between October 2011 and August 2017 was reviewed. Read More

Laryngoscope 2018 Dec;128 Suppl 6:S1-S9

Department of Plastic and Reconstructive Surgery, New York University Langone Medical Center, New York, New York.

Objectives/hypothesis: To determine if a long segment of trachea can be transplanted as a vascularized organ and to determine if a tracheal transplant is a potential surgical option for a long-segment circumferential tracheal defect.

Study Design: Animal model.

Methods: Four (two donors and two recipients) adult domestic Yorkshire swine were used. Read More

In Vivo 2019 Jan-Feb;33(1):75-78

Department of Mechanical Engineering, POSTECH, Pohang, Republic of Korea

Background/aim: Tracheal anastomosis is commonly indicated for patients with tracheal tumor, stenosis and tracheoesophageal fistula. This study was designed to evaluate the healing activity of topical application of platelet-rich plasma (PRP) jelly for tracheal reconstruction in a rabbit model.

Materials And Methods: Thirty-six healthy New Zealand White rabbits were assigned to three groups of 12 animals each. Read More

Laryngoscope 2018 Dec 25. Epub 2018 Dec 25.

Department of Otorhinolaryngology, Yeditepe University, Istanbul, Turkey.

Objectives: In this study, pirfenidone's role about reducing tracheal stenosis by suppressing fibrosis and inflammation was examined.

Methods: Tracheotomy was performed on 14 rats, and their cannulas were fixed to tracheotomy area by stoma suture. Two working groups were established. Read More

Int J Pediatr Otorhinolaryngol 2019 Feb 22;117:88-95. Epub 2018 Nov 22.

Shanghai Children's Medical Center, National Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Department of Cardiovascular Surgery, Shanghai, China. Electronic address:

Objective: To preliminarily investigate the feasibility of bioabsorption tracheal stenting for the therapeutic application of congenital tracheal stenosis (CTS).

Study Design: Experimental research.

Setting: Shanghai Children Medical Center, National Children's Medical Center. Read More

Int J Pediatr Otorhinolaryngol 2019 Feb 10;117:175-178. Epub 2018 Nov 10.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Division of Pediatric Otolaryngology, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, NY, USA.

Objectives: Surgical reconstruction of tracheal disease has expanded to include bioengineering and three dimensional (3D) printing. This pilot study investigates the viability of introducing a living functional tracheal replacement graft in a rabbit animal model.

Methods: Seven New Zealand White rabbits were enrolled and six completed participation (one intraoperative mortality). Read More

Int J Pediatr Otorhinolaryngol 2019 Mar 7;118:6-10. Epub 2018 Dec 7.

Department of ENT, Christian Medical College, Vellore, India.

Study Objectives: To review the key parameters related to the proposed modified pediatric tracheostomy technique with to determine the efficacy, safety and outcomes in a tertiary hospital in south India. Patients and Methods A retrospective chart review of all children aged below 16 years who underwent tracheostomy at a tertiary hospital in south India during the period of August 2014 to August 2016. Data on age, gender, indication for tracheostomy, primary disease condition, duration of intubation, complications and decannulation rate were recorded. Read More

Laryngoscope 2018 Dec 19. Epub 2018 Dec 19.

Department of Otolaryngology, UT Southwestern Medical Center, Dallas, Texas, U.S.A.

Objectives: Tracheal stenosis is a recognized complication of tracheostomy. Yet, the incidence and demographics of tracheal stenosis due to tracheostomies have infrequently been studied.

Methods: We performed a cross-sectional analysis of U. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Division of General Thoracic Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

A 63-year-old man who had received a permanent tracheostoma after oesophageal cancer surgery developed fistulas in the left and right main bronchi and suffered repeated aspiration pneumonia. Placing an indwelling Dumon Y-stent using a rigid bronchoscope is an option to treat fistula and stenosis at the tracheal bifurcation, but in some cases, it may be difficult to use a rigid bronchoscope in patients with a permanent tracheostoma. In this study, we report placing a Dumon Y-stent in a patient with a permanent tracheostoma using a specially modified stent and forceps instead of a rigid bronchoscope. Read More

Laryngoscope 2019 Feb 22;129(2):317-323. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Cincinnati, OH, U.S.A.

Objective: Biofilm formation on medical devices such as tracheostomy tubes (TTs) is a serious problem. The clinical impact of biofilms on the airway is still unclear. Biofilms may play a role in granulation tissue development, recurrent airway infections, and failure of laryngotracheal reconstructions. Read More

Khirurgiia (Mosk) 2018 (11):11-19

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To analyze long-term outcomes of tracheal transplantation.

Material And Methods: There were 1128 patients with cicatricial tracheal stenosis who have been operated at the Petrovsky Russian Research Center for Surgery and the Sechenov First Moscow State Medical University for the period 1963-2015.

Results: Operations have become safer. Read More

J Pediatr Surg 2018 Oct 30. Epub 2018 Oct 30.

Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London, UK. Electronic address:

Objectives: Pediatric patients born with single functional lung can be associated with symptomatic airway abnormalities. Management of such patients is not only technically demanding but is also ethically challenging. This study reports our experience of managing symptomatic airway abnormalities in pediatric patients with congenital single functional lung. Read More

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261.

Tracheal stenting currently using non-degradable stents is commonplace for treatment of trauma, prolonged intubation related adult airway obstructions, and pediatric patients-associated tracheal stenosis conditions. Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. Read More

J Clin Monit Comput 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi-Ken, 329-0498, Japan.

The oxygen reserve index (ORi™) is a new noninvasive and continuous variable, which represents a moderate hyperoxygenation status, with a unitless scale between 0.00 and 1.00. Read More

Acta Otorhinolaryngol Ital 2018 Oct;38(5):417-423

Department of Otorhinolaryngology Head and Neck Surgery, Klinikum Stuttgart, Germany.

Idiopathic progressive subglottic stenosis is a rare cause of tracheal narrowing. Partial cricotracheal resection and anastomosis can cure idiopathic stenosis, even if some patients may require multiple interventions and experience voice and swallowing deterioration. We investigated risk factors for retreatment and assessed the impact of crico-tracheal resection on functional parameters. Read More

Zhonghua Yi Xue Za Zhi 2018 Nov;98(44):3587-3591

Department of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China.

To investigate the effect of different cryoablation time on tracheal traumatic granulation formation and its mechanism. A total of 32 rabbits were randomly assigned into four groups (A-D). Group A underwent tracheotomy alone. Read More

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):864-868

Department of Oncology, Shanghai Pudong New Area People's Hospital, Pudong New Area, Shanghai 201299, China.

To explore the clinical value of endoscopic interventional therapy for locally recurrent primary lung adenoid cystic carcinoma (ACC). The clinical data of 42 patients with locally recurrent ACC were retrospectively analyzed, and the differences of tracheal and bronchial diameter, airway scoring grade and airway obstruction degree before and after treatment were compared among three treatment methods: bronchoscopic interventional therapy + palliative radiotherapy, interventional therapy alone, and non-interventional therapy. Log rank test and Cox proportional risk model multi-factor analysis were used to determine the prognostic factors of ACC patients with local recurrence, and the long-term effect of bronchoscopic interventional therapy on ACC with local recurrence was determined. Read More

Otolaryngol Head Neck Surg 2018 Nov 27:194599818815068. Epub 2018 Nov 27.

4 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Objective: Laryngotracheal stenosis (LTS) is resource-intensive disease. The cost-effectiveness of LTS treatments has not been adequately explored. We aimed to conduct a cost-effectiveness analysis comparing open reconstruction (cricotracheal/tracheal resection [CTR/TR]) with endoscopic dilation in the treatment of LTS. Read More

Tuberk Toraks 2018 Sep;66(3):239-248

Clinic of Chest Diseases, Istanbul Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.

Postintubation tracheal stenosis (PITS) is an iatrogenic complication seen increasingly often as the number of intensive care unit (ICU) bed multiply, the indications for endotracheal intubation expand and disease awareness rises. PITS has a clinical severity spectrum ranging from asymptomatic cases to patients requiring urgent interventional procedures. It should therefore always be considered in the differential diagnosis in patients with a history of intubation who present with the complaint of difficult breathing. Read More

Cardiovasc Intervent Radiol 2019 Mar 21;42(3):426-432. Epub 2018 Nov 21.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jian She Road, Zhengzhou, 450052, China.

Objective: We aimed to determine the safety and feasibility of bifurcated covered self-expanding stents for the treatment of complex tracheobronchial fistulas or stenosis.

Methods: Twenty-eight patients were treated by multiple bifurcated covered airway stents (Micro-Tech Co. Ltd. Read More

Onco Targets Ther 2018 1;11:7709-7714. Epub 2018 Nov 1.

Department of Respiratory Medicine, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing 211100, Jiangsu, China,

Objective: The aim of this study was to investigate the clinical effects and feasibility of using flexible bronchoscopy intervention in cases of malignancy that causes central airway stenosis and respiratory failure.

Methods: The clinical data of patients who were admitted to the Department of Respiratory Medicine at the First Affiliated Hospital of Nanjing Medical University and underwent treatment of a malignant tumor with central airway stenosis and respiratory failure by flexible bronchos-copy from February 2010 to May 2013 were analyzed using a retrospective method. The age, gender, location, extent of airway stenosis, interventional therapy, efficacy, and complications for 12 patients were collected and analyzed using the SPSS 13. Read More

Emerg Med Clin North Am 2019 Feb;37(1):109-119

Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA.

Tracheostomy is a common procedure for long-term airway management. Although the overall complication rate is greater than 50%, the incidence of serious complications is low. These serious complications can, however, lead to significant morbidity and mortality and it is incumbent on the emergency provider to be prepared to deal with such tracheostomy-related emergencies. Read More

Artif Cells Nanomed Biotechnol 2018 Nov 19:1-10. Epub 2018 Nov 19.

a Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, College of Medicine , Hallym University , Chuncheon , Republic of Korea.

The purpose of this study was to evaluate whether the prior implantation of a 3D-printed polycaprolactone (PCL) artificial trachea in the omentum is beneficial for revascularization of the scaffold and reduces associated complications in the reconstruction of a circumferential tracheal defect. Ten New Zealand rabbits were divided into 2 groups: (1) PCL-OC group (PCL scaffold cultured in omentum for 2 weeks before transplantation) and (2) PCL group. In the PCL-OC group, newly formed connective tissue completely covered the luminal surface of the scaffold with mild inflammation at 2 weeks postoperatively; a minor degree of stenosis was noted at 8 weeks postoperatively. Read More

Kyobu Geka 2018 11;71(12):1018-1021

Division of Thoracic Surgery, Kobe University, Kobe, Japan.

Idiopathic subglottic stenosis (ISS) is defined as the narrowing of the upper airway without any known cause. A 40-year-old female was referred to our hospital with the complaint of exacerbation of dyspnea causing difficulty in going out. Chest computed tomography (CT) scan and bronchoscopy revealed subglottic tracheal stenosis with a luminal diameter of 5 mm at the narrowest part. Read More

A A Pract 2018 Nov 12. Epub 2018 Nov 12.

Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Transcatheter aortic valve replacement (TAVR) is an alternative to traditional surgery in patients considered to be at high or intermediate risk for open surgical repair of aortic stenosis. Despite its overall safety and efficacy, TAVR is associated with potentially serious complications including major vascular injury. Tracheal compression resulting from vascular pathology has been previously reported; however, airway compromise secondary to vascular injury during TAVR has not been described. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2018 Nov;41(11):857-862

Department of Endoscopic Diagnosis & Treatment, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.

To investigate the efficacy and safety of cryotherapy combined with balloon dilatation through electronic bronchoscope in the management of airway occlusion caused by scar stenosis type of tracheobronchial tuberculosis (TBTB). From December 2008 to May 2016, 98 cases of airway occlusion caused by scar stenosis of TBTB were diagnosed by microbiology, histopathology, CT (computer tomography), bronchial reconstructions and bronchoscopy. All patients underwent routine anti-tuberculosis chemotherapy and cryotherapy through bronchoscope. Read More

Med Biol Eng Comput 2018 Nov 13. Epub 2018 Nov 13.

Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, 560-8531, Japan.

Tracheal flow in infants with congenital tracheal stenosis (CTS) was numerically investigated using subject-specific airway models before and after reconstructive surgery. We quantified tracheal flow based on airway resistance during inhalation, and compared it between controls and patients before and after surgery. The airway resistance in each subject was assessed using geometrical parameters of the trachea: the minimum cross-sectional area A, the minimum cross-sectional area normalized by the standard deviation of the cross-sectional area A/σ, the area ratio of the minimum and maximum cross-sectional area A/A, and ratio of the normalized standard deviation of cross-sectional area to the mean cross-sectional area σ/A. Read More