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Harefuah 2019 Jan;158(1):60-64

Ophthalmology Department, Hillel Yaffe Medical Center.

Introduction: The goal of all glaucoma surgery is to lower eye pressure to prevent or reduce damage to the optic nerve. Standard glaucoma surgeries - trabeculectomy, ExPRESS shunts and external tube-shunts like the Ahmed and Baerveldt valves - are major surgeries. While they are very often effective at lowering eye pressure and preventing progression of glaucoma, they have a long list of potential complications. Read More

Int J Ophthalmol 2019 18;12(1):66-72. Epub 2019 Jan 18.

Department of Ophthalmology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China.

Aim: To evaluate whether the level of thrombospondin-1 (TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma (PACG).

Methods: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy (case group) and 78 age- and sex-matched patients with PACG who underwent successful trabeculectomy (control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-β2 levels with an enzyme-linked immunosorbent assay method. Read More

J Ophthalmol 2018 16;2018:5149154. Epub 2018 Dec 16.

Department of Ophthalmology, United Christian Hospital, Kowloon, Hong Kong.

Purpose: To compare the surgical outcome of combined phacoemulsification and endoscopic cyclophotocoagulation (phacoECP) versus combined phacoemulsification and mitomycin C-augmented trabeculectomy (phacoTbx) in patients with coexisting glaucoma and visually significant cataract.

Methods: A retrospective review of 89 eyes of 89 patients who received phacoECP (=49) and phacoTbx (=40) was carried out at a tertiary eye center in Hong Kong. The minimum follow-up period was 6 months. Read More

Ophthalmologe 2019 Jan 14. Epub 2019 Jan 14.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

The Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA, USA) is a novel goniotomy instrument for opening Schlemm's canal. Performing the procedure is comparable to the Trabectome (Neomedix, Tustin, CA, USA) under gonioscopic control with the major difference that the trabeculectomy is created by a dual blade instead of electroablation. The currently available clinical data are limited to a small number of retrospective studies with ≤1 year of follow-up. Read More

Medicine (Baltimore) 2019 Jan;98(2):e14026

Department of Ophthalmology and Visual Science, St Vincent's Hospital College of Medicine, Catholic University of Korea, Seoul, South Korea.

Objectives: Open-angle glaucoma (OAG) imposes high disease burden in South Korea. Although various effective interventions are available to manage the progression of OAG, there is limited data on the cost-effectiveness of these treatment strategies in South Korea.

Methods: Using a Markov cohort model, we evaluated the cost-effectiveness of 3 major treatment strategies (medication, laser trabeculoplasty, and trabeculectomy) for South Korean patients with OAG. Read More

Am J Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; Center for Eye Policy and Innovation, University of Michigan, Ann Arbor, MI; Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, MI. Electronic address:

Purpose: To characterize differences in resource utilization and cost of managing enrollees with exfoliation glaucoma (XFG) compared to primary open-angle glaucoma (POAG).

Design: Retrospective utilization and cost comparison using Medicare claims data.

Methods: We identified Medicare beneficiaries with XFG or POAG and ≥5 years of continuous enrollment from January 2008 to December 2014. Read More

J Fr Ophtalmol 2019 Jan 28;42(1):57-62. Epub 2018 Dec 28.

Service d'ophtalmologie, CHU Mohamed VI, avenue Ibn Sina, BP2360 Principal, Marrakech, Maroc.

The goal of our work is to analyze the clinical aspects, study the change in intraocular pressure and functional prognosis after trabeculectomy and amblyopia treatment of children followed for congenital glaucoma. The present study is a retrospective study including 86 patients (143 eyes) followed over a period from March 2009 to September 2015. The median age at diagnosis was 6 months. Read More

Medwave 2018 Dec 19;18(8):e7390. Epub 2018 Dec 19.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Oftalmología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: Aqueous shunt has emerged as an alternative technique to trabeculectomy, which is considered the standard treatment for glaucoma surgery. Currently, it is mainly indicated after failure of trabeculectomy or in some types of glaucoma with high risk of failure. However, there is still controversy regarding its effectiveness compared to trabeculectomy. Read More

Int J Ophthalmol 2018 18;11(12):1941-1944. Epub 2018 Dec 18.

Ophthalmology Department, Central Lisbon Hospital Center, Lisbon 1169050, Portugal.

Aim: To evaluate and compare the quality of life of patients submitted to XEN implant or trabeculectomy and the relationship with potentially involved variables.

Methods: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN (group 1) and trabeculectomy (group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure (IOP). Read More

Int J Ophthalmol 2018 18;11(12):1909-1915. Epub 2018 Dec 18.

Department of Ophthalmology, Ordu State Hospital, Ordu 52100, Turkey.

Aim: To compare the effects of bevacizumab and pazopanib with corticosteroids on wound healing after trabeculectomy.

Methods: In the study, 35 New Zealand white rabbits were randomly divided into five groups. Apart from the first group, limbus-based trabeculectomy was performed for the eyes of rabbits. Read More

Indian J Ophthalmol 2019 Jan;67(1):95-100

Department of Glaucoma, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Purpose: To evaluate the surgical outcomes of repeat trabeculectomy augmented with risk factor adjusted mitomycin C (MMC) exposure in eyes with previous failed trabeculectomy.

Methods: Case records of 38 eyes of 37 patients with previous failed filter who underwent repeat trabeculectomy with MMC were reviewed retrospectively. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP) reduction, requirement of anti-glaucoma medications, postoperative complications, and surgical success (defined as IOP of ≤21 mmHg and >5 mmHg along with 20% reduction from preoperative IOP with or without adjuvant medications) at 1-year postoperatively. Read More

Int J Mol Sci 2018 Dec 18;19(12). Epub 2018 Dec 18.

Biomarker Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1., 4032 Debrecen, Hungary.

Tears are a constantly available and highly valuable body fluid collectable by non-invasive techniques. Although it can give information on ocular status and be used for follow-ups, tear analysis is challenging due to the low amount of sample that is available. Proximity extension assay (PEA) allows for a sensitive and scalable analysis of multiple proteins in a single run from a one-µL sample, so we applied this technique and examined the amount of 184 proteins in tears collected at different time points after trabeculectomy. Read More

Eur J Ophthalmol 2018 Dec 19:1120672118819668. Epub 2018 Dec 19.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose:: To report on the clinical presentation and surgical treatment (procedure and outcome(s)) of glaucoma in children with facial port wine stain.

Materials And Methods:: This is a retrospective chart review of children with facial port wine stain referred to Alexandria University paediatric ophthalmology practice from 2005 to 2016. The charts of 22 children (44 eyes) with facial port wine stain were reviewed. Read More

Curr Opin Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Purpose Of Review: This article reviews recent studies related to tube shunt surgery.

Recent Findings: Medical claims data and surveys of glaucoma surgeons demonstrate that tube shunts are being selected with increasing frequency as an alternative to trabeculectomy. A 5-year pooled analysis of the Ahmed Baerveldt comparison study and Ahmed versus Baerveldt study found a higher rate of surgical success with the Baerveldt glaucoma implant compared with the Ahmed glaucoma valve, but Baerveldt implantation carried a higher risk of hypotony. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13643

Honghui Hospital, Xi'an Jiaotong University, No. 76 Nanguo Road, District Beilin, Xi'an, Shaanxi, China.

Study Design: A retrospective study.

Objective: To investigate the effectiveness and safety of intravenous tranexamic acid for reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis (TSS).

Methods: This is a retrospective observational study of 42 patients with multilevel TSS admitted from December 2016 to October 2017 to the spine department of Honghui Hospital who underwent posterolateral bone graft fusion with posterior laminectomy and decompression fixation. Read More

Cochrane Database Syst Rev 2018 Dec 16;12:CD012742. Epub 2018 Dec 16.

Ophthalmology, Nottingham University Hospital, Derby Road, Nottingham, UK, NG7 2UH.

Background: Glaucoma is a leading cause of irreversible blindness. Subconjunctival draining minimally-invasive glaucoma devices such as the Xen gelatin implant and InnFocus stent have been introduced as a treatment to prevent glaucoma progressing.These implants provide a channel to allow aqueous humour from the anterior chamber of the eye to drain into the subconjunctival space on the surface of the eye thus reducing intraocular pressure (IOP) and mimicking the mechanism of the most commonly undertaken glaucoma surgery, trabeculectomy. Read More

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, University of North Carolina at Chapel Hill.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Allure Laser Center & Medispa.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Department of operating room, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

Can J Ophthalmol 2018 Dec 3;53(6):588-594. Epub 2018 Apr 3.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To compare the efficacy and safety of ab interno trabeculectomy with the Trabectome combined with cataract surgery (phaco-AIT) versus Trabeculectomy with mitomycin C combined with cataract surgery (phaco-Trab) in open-angle glaucoma.

Methods: A prospective randomized controlled trial with a single surgeon and surgical center was undertaken. Patients were recruited from July 2009 to October 2014. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1389-1394

Center of Myopia, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.

Objective: To study the anti- scarring effect of rapamycin in rabbits receiving glaucoma filtering surgery.

Methods: Ninety-six Chinchilla rabbits were randomized equally into 3 rapamycin treatment groups and one control group. All the rabbits underwent trabeculectomy, after which the rabbits in the 3 rapamycin groups were treated with eye drops containing 1%, 3%, or 5% rapamycin in the operated eyes, and those in the control groups were given castor oil 4 times a day. Read More

Vestn Oftalmol 2018 ;134(5):99-103

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

At present, phacoemulsification and trabeculectomy are the most widespread surgery methods in cataract and glaucoma treatment, generally recognized as the gold standard. Among elderly patients, comorbid glaucoma and cataract are extremely prevalent, so the order of the two surgeries and the time interval between them are pivotal choices when planning treatment strategy. The reason for it is that almost any eye surgery is considered a risk factor for long-term trabeculectomy effectiveness. Read More

Vestn Oftalmol 2018 ;134(5. Vyp. 2):250-256

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

The article reviews the results of using optical coherence tomography (OCT) - a non-invasive non-contact examination method for obtaining a tomographic slice image of the site of glaucoma surgery. The method helped reveal the functional relationships between the newly created outflow pathways and various parameters of the filtering bleb such as its linear dimensions, wall structure, presence of microcysts, position of drainage, etc. Due to its high resolution and noninvasiveness, OCT can be reliably used to examine the structure of aqueous outflow pathways in different postoperative periods with accuracy close to morphometric. Read More

Adv Ther 2019 Jan 28;36(1):31-43. Epub 2018 Nov 28.

Department of Medical and Surgical Specialties, University of Brescia, Brescia, Italy.

Canaloplasty is a relatively new non-penetrating surgery for the reduction of intraocular pressure in patients affected by glaucoma. The technique uses a microcatheter to perform a 360 º cannulation of Schlemm's canal and leaves in place a tension suture providing an inward distension. It aims to restore the physiological outflow pathways of the aqueous humour and is independent of external wound healing. Read More

Minerva Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophthalmology, Harbin Ophthalmology Hospital, Harbin, China.

Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):387-393. Epub 2018 Nov 28.

Mayo Clinic, Rochester, MN.

Glaucoma is the leading cause of irreversible blindness in Africa. The condition is treatable but not curable. There are numerous obstacles to glaucoma care in Africa, including availability, accessibility and affordability of treatments, as well as medication nonadherence among patients. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.

Purpose: To analyze the longitudinal change in Bruch's membrane opening minimal rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) after glaucoma surgery via ab-interno trabeculectomy in adult glaucoma patients.

Methods: Retrospective audit of 65 eyes of 65 participants undergoing ab-interno trabeculectomy using electroablation of the trabecular meshwork. In 53 eyes, surgery was combined with phacoemulsification and posterior chamber lens implantation. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophthalmology, Hospital Universitario Ramón y Cajal (IRYCIS), Carretera de Colmenar Km 9.100, 28034, Madrid, Spain.

Mol Med Rep 2018 Nov 20. Epub 2018 Nov 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.

Subconjunctival fibrosis represents the primary cause of postoperative failure of trabeculectomy, and at present there is a lack of effective intervention strategies. The present study aimed to investigate the effect of the mitogen‑activated protein kinase kinase (MEK) inhibitor U0126 on human tenon fibroblast (HTF) myofibrosis transdifferentiation, and to illuminate the underlying molecular mechanisms involved. It was demonstrated that U0126 significantly inhibited the proliferation, migration and collagen contraction of HTFs stimulated with TGF‑β1. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 26. Epub 2018 Nov 26.

University of Pittsburgh, Pittsburgh, USA.

J Curr Glaucoma Pract 2018 May-Aug;12(2):85-89. Epub 2018 Aug 1.

Anterior Segment Specialist, Al-Adan Hospital, Kuwait, Kuwait.

Aim: To assess the role of porous collagen in deep sclerectomy (DS), with and without trabeculo-Descemet membrane (TDM) rupture.

Patients And Methods: Forty-six eyes with different types of open-angle glaucoma and medically uncontrolled intraocular pressure (IOP) were selected. DS was performed in all cases. Read More

J Curr Glaucoma Pract 2018 May-Aug;12(2):64-66. Epub 2018 Aug 1.

Consultant and Surgeon, Aintree University Hospitals NHS Foundation Trust, Longmoor Lane, Liverpool, UK.

Aim: Concerns regarding 5-Fluorouracil (5-FU) corneal toxicity have resulted in various ways of reducing its corneal exposure during post-operative trabeculectomy bleb manipulation. This study investigates the properties of various topical agents used to induce the precipitation of this compound.

Materials And Methods: This is a double-blind, descriptive, laboratory study comparing five different potential precipitants of 5-FU (proxymetacaine (proxy), oxybuprocaine (oxy), ametho-caine (ameth), fluorescein (flor), proxymetacaine + fluorescein (proxy-flor) to a control group (normal saline). Read More

Br J Ophthalmol 2018 Nov 24. Epub 2018 Nov 24.

Department of Epidemiology and International Eye Health, Institute of Ophthalmology, London, UK.

Aims: To compare success proportions at 5 years in three surgical groups: group 1, trabeculectomy alone; group 2, trabeculectomy followed by cataract surgery within 2 years; and group 3, trabeculectomy performed on a pseudophakic eye.

Methods: A retrospective cohort study. 194 eyes of 194 patients were identified with at least 5 years' follow-up post trabeculectomy (N=85, 60 and 49 in groups 1, 2 and 3, respectively). Read More

Int Ophthalmol 2018 Nov 23. Epub 2018 Nov 23.

Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.

Purpose: We aimed to investigate the effect of combined phacotrabeculectomy, trabeculectomy and phacoemulsification on the corneal endothelium in the early stage.

Materials And Methods: In this prospective and non-randomized study, three groups were identified each consisting of 20 eyes (Group I phacotrabeculectomy, group II trabeculectomy, group III phacoemulsification). In the pre- and postop month 1, corneal endothelial cell density (CECD), coefficient of variation (CV) (polymegathism) and hexagonality (Hex) (pleomorphism) were measured by means of a non-contact specular microscope (Nidek CEM-530, NIDEK Co. Read More

Eye (Lond) 2019 Jan 22;33(1):110-119. Epub 2018 Nov 22.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

Acute primary angle closure requires emergency management that involves a rapid lowering of the intraocular pressure and resolution of relative pupil block - the most common mechanism of angle closure. Emergency strategies for lowering intraocular pressure include medical treatment and argon laser peripheral iridoplasty. Anterior chamber paracentesis and diode laser transcleral cyclophotocoagulation may be considered in special situations. Read More

J Glaucoma 2019 Jan;28(1):20-26

Jasti V Ramanamma Children's Eye Care Center.

Purpose: The purpose of this study was to report presentation and outcomes of coexisting congenital glaucoma with retinopathy of prematurity (ROP) in "Indian Twin cities ROP study (ITCROPS)."

Methods: Children with ROP and congenital glaucoma were identified from ITCROPS (prospective digital database) between 1997 and 2016. The presentation, interventions, and outcomes for glaucoma and ROP were evaluated. Read More

Cont Lens Anterior Eye 2019 Feb 12;42(1):123-126. Epub 2018 Nov 12.

Visser Contact Lens Practice, Sint Annastraat 93, 6524 EJ Nijmegen, the Netherlands. Electronic address:

Purpose: Ocular hypotony after trabeculectomy may be treated medically, surgically and with a tamponade. Three cases are reported in which a scleral lens was applied to treat ocular hypotony after mitomycin C (MMC) augmented trabeculectomy.

Methods: In this retrospective case series the records of three eyes of three patients who developed ocular hypotony after they had undergone trabeculectomy augmented with MMC were evaluated. Read More

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):849-854

Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To investigate the clinical characteristics, surgical approaches and postoperative effects associated with congenital fibrovascular pupillary membranes. A retrospective study design was used. Thirteen children (13 eyes) with congenital fibrovascular pupillary membranes, treated in Beijing Children's Hospital from January 2014 to December 2017 were included. Read More

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):806-810

Department of Ophthalmology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.

The filtration bleb dependent surgeries, such as trabeculectomy, are the main methods for glaucoma treatment in China. However, the filtration bleb scarring after the surgery has always been a challenge to long-term results. In recent years, with the application of anti-glaucoma non-filtering bleb dependent surgery, the surgery complications of filter bubble dependence have been avoided, such as shallow anterior chamber and leakage of filtering bleb. Read More

Biosci Rep 2018 Dec 7;38(6). Epub 2018 Dec 7.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou 510060, China

Acute primary angle-closure (APAC) eyes show an early 'acute inflammatory' condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study involved 40 eyes of 32 PACG patients who required trabeculectomy and 24 eyes of 24 patients who required cataract surgery. The aqueous humor samples were collected at the time of surgery. Read More

Clin Ophthalmol 2018 23;12:2157-2165. Epub 2018 Oct 23.

VER Excellence in Ophthalmology, Goiânia, Goiás, Brazil,

Objective: Evaluate the pattern of intraocular pressure (IOP) variations through the pneumatic tonometer, between two specific surgical techniques, and the possible variables that may influence the behavior of this pressure.

Methods: Retrospective cross-sectional study carried out through the review of electronic medical records of a private ophthalmological reference hospital in the city of Goiânia, Goiás, Brazil, from 2012 to 2016, comprising of a sample of 550 eyes. The analyzed variables were, age, gender, IOP, axis, pachymetry, anterior chamber depth, and axial length. Read More

F1000Res 2018 22;7:876. Epub 2018 Jun 22.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Tehran, 19839-63113, Iran.

The aim of this study was to compare the safety and efficacy of primary trabeculectomy with mitomycin C and Ahmed glaucoma valve (AGV) implantation in patients with Fuchs heterochromic iridocyclitis (FHIC)-related glaucoma, a rare complication of an uncommon form of uveitis. s In this retrospective comparative case series, 26 FHIC-associated glaucoma patients received trabeculectomy (n=12) or an AGV (n=14). Primary outcome measures were surgical success, defined as intraocular pressure (IOP) ≤21 mmHg, decreasing ≥20% from baseline, and no secondary glaucoma surgery. Read More

PLoS One 2018 6;13(11):e0206040. Epub 2018 Nov 6.

Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wroclaw, Poland.

Purpose: To assess whether lamina cribrosa depth (LCD) reduction and the rate of change in LCD over time (ΔLCD/Δt) is associated with retinal nerve fiber layer (RNFL) thickness and the rate of RNFL thinning over time (ΔRNFL/Δt) to test the hypothesis that, in a long term, RNFL thinning occurs irrespectively to the displacement of the lamina cribrosa following glaucoma surgery.

Methods: Twenty-nine primary open-angle glaucoma patients underwent glaucoma surgery. Sixteen patients underwent trabeculectomy and 13 patients undertook non-penetrating deep sclerectomy. Read More

J Glaucoma 2019 Jan;28(1):27-31

Department of Ophthalmology, University of Washington, Seattle, WA.

Purpose: The purpose of this study was to assess long-term outcomes and complications of smaller-incision trabeculectomy revision with mitomycin (MMC) in glaucoma patients.

Methods: Review of patients undergoing trabeculectomy revision with MMC for inadequate intraocular pressure (IOP) control. After dissection of subconjunctival fibrosis through a smaller (median, 5 mm) incision, MMC was topically applied and episcleral fibrosis was incised. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 3. Epub 2018 Nov 3.

, Sao Paulo, SP, Brazil.

Sci Rep 2018 Nov 1;8(1):16168. Epub 2018 Nov 1.

Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Yoshida, Japan.

We compared complications between Ex-PRESS implantation and trabeculectomy for 2 years after surgery. Sixty-four open-angle glaucoma eyes were randomly assigned to treatment with trabeculectomy (n = 32) or Ex-PRESS implantation (n = 32). The primary outcomes were postoperative complications, including reduction of the endothelial cell density (ECD) of the cornea, cataract progression and the frequency of other late postoperative complications. Read More

Eye (Lond) 2018 Oct 31. Epub 2018 Oct 31.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Aim: To evaluate refractive outcomes of cataract surgery with intraocular lens (IOL) implantation in operated eyes of primary congenital glaucoma (PCG).

Design: A retrospective case-control study.

Methods: Patients of PCG who developed cataract following trabeculectomy with trabeculotomy were recruited. Read More

BMC Ophthalmol 2018 Oct 30;18(1):281. Epub 2018 Oct 30.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL, 33418, USA.

Background: A major obstacle that academic institutions face is the steep learning curve for cornea fellows initially learning to perform Descemet Stripping Endothelial Keratoplasty (DSEK). The purpose of this study is to evaluate the outcomes of complex DSEK performed by cornea fellow supervised by an attending surgeon at an academic institution.

Methods: Patients who underwent a complex DSEK procedure performed by a cornea fellow during the years 2009-2013 were included. Read More