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Ophthalmic Res 2020 Jun 4. Epub 2020 Jun 4.

The characteristics of the conjunctival bleb are some of the most important factors for the surgical success of glaucoma filtering surgery. To improve surgical outcome, we investigated histology of bleb after three glaucoma surgeries. Surgery was performed in the 21 white rabbits. Read More

Clin Ophthalmol 2020 12;14:1277-1285. Epub 2020 May 12.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: To evaluate the safety and efficacy of non-penetrating deep sclerectomy with a collagen implant versus trabeculectomy in primary congenital glaucoma.

Subjects And Methods: This was a retrospective interventional comparative non-randomized clinical study that included 80 eyes of 80 children presenting with primary congenital glaucoma under the age of 3 years. Forty eyes have undergone non-penetrating deep sclerectomy (NPDS) and the other 40 eyes have undergone penetrating trabeculectomy. Read More

Arq Bras Oftalmol 2020 Jun 29;83(3):215-224. Epub 2020 May 29.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: Our initial goal was to compare the efficacy and safety of a glaucoma drainage device and trabeculectomy for children with primary congenital glaucoma after angular surgery failure. However, we discontinued the study due to the rate of complications and wrote this report to describe the results obtained with the two techniques in this particular group.

Methods: This was a parallel, non-masked, controlled trial that included patients aged 0-13 years who had undergone previous trabeculotomy or goniotomy and presented inadequately controlled glaucoma with an intraocular pressure ≥21 mmHg on maximum tolerated medical therapy. Read More

Int Ophthalmol 2020 Jun 1. Epub 2020 Jun 1.

Ophthalmology Department, Faculty of Medicine, Menofia University, Shebin El Kom, Egypt.

Objective: This prospective study aimed to compare the surgical outcomes of ab externo 240-degree trabeculotomy and trabeculotomy-trabeculectomy in managing primary congenital glaucoma (PCG).

Patients And Methods: The study included 30 eyes of 30 patients aged less than 3 years who were diagnosed with PCG and was conducted in Menofia University Hospital between November 2018 and January 2020. The studied eyes were divided into two equal groups. Read More

J Glaucoma 2020 Jun 1. Epub 2020 Jun 1.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Precis: Improvements in post-trabeculectomy visual field outcomes were found to be significantly associated with pre-operative nerve fiber layer thickness parameters extracted from the sectorized structure-function relationship, baseline visual field and severity of glaucoma.

Objective: To determine whether the pre-operative structure-function relationship helps to predict visual outcomes at one-year post-trabeculectomy.

Patients And Methods: 91 eyes from 87 participants who successfully underwent trabeculectomy were included in our study. Read More

Curr Eye Res 2020 Jun 1. Epub 2020 Jun 1.

Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi, India.

Purpose To describe a goats' eye training model for teaching of trabeculectomy and releasable suture techniques for Ophthalmology residents. Methods A descriptive report explaining the methodology for setting up a goats' eye wet-lab model for teaching trabeculectomy for Ophthalmology residents. It details the approaches to eyeball preparation, steps of surgery, application and release of two representative types of 'releasable sutures' in a step-by-step manner. Read More

Jpn J Ophthalmol 2020 May 30. Epub 2020 May 30.

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan.

Purpose: This study evaluated the surgical practice patterns of glaucoma management followed by glaucoma specialists in Japan.

Methods: A survey was administered to 50 glaucoma specialists who were councilors in the Japan Glaucoma Society about surgical preferences and postoperative glaucoma care.

Results: All 50 glaucoma specialists participated in the survey. Read More

Indian J Ophthalmol 2020 Jun;68(6):1090-1094

L.V. Prasad Eye Institute, Bhubaneswar, Odisha, India.

Purpose: This study aims to evaluate efficacy and outcomes of manual small incision cataract surgery with trabeculectomy (Group 1) and phacoemulsification with trabeculectomy (Group 2) in pseudoexfoliation glaucoma (PXG).

Methods: In this retrospective comparative observational case series, All patients with PXG who underwent either small incision cataract surgery or phacoemulsification with trabeculectomy from 2011-2015 were studied. Data compared included best corrected visual acuity (BCVA), intraocular pressure (IOP), total surgical time, and incidence of intra/postoperative complications. Read More

J Glaucoma 2020 May 22. Epub 2020 May 22.

Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo.

Purpose: The purpose of this work was to report a new method for the repair of ischemic bleb leaks. Bleb leakage is a serious complication of glaucoma filtering surgery with mitomycin C. Many surgical methods have been proposed to seal the leakage from a bleb; however, this novel plication method is effective, relatively easy to perform, and safe. Read More

Eur J Ophthalmol 2020 May 26:1120672120924339. Epub 2020 May 26.

Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Purpose: To compare the short-term changes in corneal endothelial cells after trabeculectomy or XEN Gel Stent implantation.

Design: Prospective, interventional, comparative study.

Methods: Changes in corneal endothelium in patients that underwent XEN Gel Stent implantation or trabeculectomy were prospectively evaluated. Read More

Eur J Ophthalmol 2020 May 26:1120672120924343. Epub 2020 May 26.

Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

Purpose: Bleb dysfunction may occur as a late complication following glaucoma filtration surgery. Over-filtering, thinning and cystic blebs can lead to hypotony, leak and corneal dellen. We report our surgical management and outcomes of this specific entity using donor scleral patch grafts. Read More

Surv Ophthalmol 2020 May 22. Epub 2020 May 22.

Save Sight Institute, Faculty of Medicine and Health, University of Sydney; Sydney Eye Hospital, Macquarie St, Sydney, Australia.

Trabeculectomy has been performed since the mid-1960s and remains the gold standard for glaucoma surgery. Newer surgical options have evolved, collectively referred to as minimally invasive glaucoma surgeries (MIGS). Despite producing large intraocular pressure decreases, full-thickness procedures into the subconjunctival space may be limited by fibrosis. Read More

Am J Ophthalmol 2020 May 21. Epub 2020 May 21.

University of Toronto, Department of Ophthalmology and Vision Sciences, Toronto, Canada.

Purpose: To evaluate 4-year outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with prior glaucoma surgery.

Design: Retrospective, comparative case series METHODS: Patients with prior trabeculectomy or glaucoma-drainage-device (GDD) implantation, who later underwent DMEK (study group) were matched for follow-up duration with Fuch's dystrophy DMEK patients (control group). Minimum follow-up was 18 months. Read More

Arch Soc Esp Oftalmol 2020 May 15. Epub 2020 May 15.

Departamento de Oftalmología, Hospital Puerta de Hierro Majadahonda, Madrid, España; Departamento de Oftalmología, Universidad de Castilla La Mancha, Albacete, España.

Case Report: A 31-year-old male was referred for evaluation after being diagnosed with Cushing syndrome secondary to a pituitary microadenoma. He presented with a reduced visual acuity and high intraocular pressure (IOP) of 48mmHg in both eyes. The examination with biomicroscopy showed normal anterior segment, increased cup to disc ratio, and open angle. Read More

Eur J Ophthalmol 2020 May 18:1120672120924340. Epub 2020 May 18.

Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Purpose: The aim of the study was to analyze morphological parameters of apparently functional filtering blebs with anterior segment optical coherence tomography at 1 month post trabeculectomy and to correlate these parameters with intraocular pressure at 6 months of follow-up to predict the short-term success of trabeculectomy.

Methods: In this cross-sectional, descriptive study, apparently functional blebs were evaluated using anterior segment optical coherence tomography with crossline scans after 1 month of trabeculectomy.

Results: A total of 55 eyes of 55 cases with mean age 49. Read More

Crit Rev Eukaryot Gene Expr 2020 ;30(1):39-43

University Institute of Medical Lab Technology, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.

Glaucoma is the second most prominent cause of impaired vision in the world. Over 60 million individuals are presently affected, and 12 million are sightless as a result. Primary congenital glaucoma (PCG) is a childhood disease that can lead to blindness in newborns and very young children. Read More

Graefes Arch Clin Exp Ophthalmol 2020 May 15. Epub 2020 May 15.

Ophthalmology Clinic, Department of Medicine and Aging Sciences, University G. d'Annunzio of Chieti-Pescara, Via dei Vestini, 66100, Chieti, CH, Italy.

Purpose: To describe and compare the conjunctival filtering bleb features after XEN gel implantation and trabeculectomy using anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM).

Methods: Fifty-two patients who underwent completely successful trabeculectomy (24 eyes) or completely successful XEN gel implantation (28 eyes) were consecutively enrolled. At the sixth-month follow-up, filtering blebs were analyzed with AS-OCT and IVCM. Read More

Mil Med 2020 May 15. Epub 2020 May 15.

Section of Ophthalmology, Providence VA Medical Center, Providence, RI 02908.

Introduction: Glaucoma surgical practice patterns are not well described in the United States (US). This study aims to evaluate the indications for and potential barriers to glaucoma surgery in the Veterans Health Administration (VHA).

Materials And Methods: An anonymous 10-question survey using REDCap (Nashville, TN) software was sent by mail (with web link) and email to ophthalmology chiefs at the 86 academically affiliated Veterans Affairs Medical Centers (VAMCs). Read More

J Glaucoma 2020 May 12. Epub 2020 May 12.

St. Peter's Hospital, Albany, New York.

PRéCIS: Combining Trabectome or iStent with phacoemulsification equally reduces IOP and IOP-lowering medication burden during a 24-month follow-up, with a possible advantage to the Trabectome in the early postoperative period.

Purpose: Intra-subject same-surgeon comparison between phacoemulsification combined with Trabectome (Phaco/Trabectome) versus one 1st-generation iStent (Phaco/iStent).

Settings: Private glaucoma and cataract practice. Read More

BMJ Case Rep 2020 May 13;13(5). Epub 2020 May 13.

VST Center for Glaucoma Care, LV Prasad Eye Institute, Hyderabad, India

A 5-year-old boy with failed combined trabeculotomy and trabeculectomy underwent Ahmed glaucoma valve (AGV) implantation and presented 5 weeks postoperatively, with sudden onset proptosis downward displacement of the globe, limited extraocular movements and displacement of tube from anterior chamber. CT scan of the orbits showed a large cystic bleb with posterior dislocation of the implant and was explanted. In vitro testing of implant for fluid flow characteristics revealed a dysfunctional valve with anterior leak, which could have possibly lead to anterior and inferior fluid accumulation resulting in displacement of implant, a probable cause for this rare complication. Read More

Int J Ophthalmol 2020 18;13(4):591-598. Epub 2020 Apr 18.

Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Aim: To assess the changes in the anterior chamber parameters using Pentacam following four different lines of treatment of primary angle-closure glaucoma (PACG).

Methods: A retrospective comparative study included 126 patients (126 eye) presented within 24-48h after acute angle-closure glaucoma (AACG). Patients were divided into 2 groups: group A (68 eyes) with controlled intraocular pressure (IOP) ≤21 mm Hg, which included subgroup A1 (34 eyes) with clear lens underwent Nd:YAG laser peripheral iridotomy (LPI) and subgroup A2 (34 eyes) with cataract underwent standard phacoemulsification; and group B (58 eyes) with uncontrolled IOP, which included subgroup B1 (30 eyes) with clear lens underwent trabeculectomy and subgroup B2 (28 eyes) with cataract underwent combined phacoemulsification and trabeculectomy. Read More

Eye (Lond) 2020 May 12. Epub 2020 May 12.

NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.

Purpose: To examine the safety and economic effect of using fibrin glue to reduce suturing of a donor patch graft and in conjunctival closure during aqueous shunt implantation.

Study Design: Retrospective interventional case series of 150 patients from a single institution including historical controls from before the introduction of the change in technique. The surgery was performed by multiple glaucoma surgeons. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):144-154

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objectives: To observe the short-term efficacy of EX-PRESS filtration shunt implantation in the treatment of open angle glaucoma, and to analyze the safety and effectiveness of the surgical method.

Methods: From April 2017 to January 2018, a total of 28 eyes of 17 open angle glaucoma patients in Xiangya Hospital of Central South University were screened. Among them, 16 eyes in the experimental group were treated with EX-PRESS filtration shunt (P200)implantation, and 12 eyes in the control group underwent trabeculectomy. Read More

J Ophthalmol 2020 21;2020:8720450. Epub 2020 Apr 21.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Purpose: To evaluate the effect of phacoemulsification and intraocular lens (IOLs) implantation in eyes with medically uncontrolled primary angle-closure glaucoma (PACG) previously treated with trabeculectomy and to quantify the anatomical changes in the anterior chamber angle by ultrasound biomicroscopy (UBM).

Methods: Forty-four eyes of 37 consecutive patients with medically uncontrolled PACG coexisting cataracts with a surgical history of trabeculectomy were included in this study. Each patient underwent phacoemulsification and IOL implantation. Read More

Graefes Arch Clin Exp Ophthalmol 2020 Jun 5;258(6):1211-1216. Epub 2020 May 5.

Department of Ophthalmology, University of Würzburg, Josef-Schneider-Straße 11, 97080, Würzburg, Germany.

Purpose: To characterize the effects of netarsudil on the aqueous humor outflow tract distal to the trabecular meshwork (TM). We hypothesized that netarsudil increases outflow facility in eyes with and without circumferential ab interno trabeculectomy (AIT) that removes the TM.

Methods: Sixty-four porcine anterior segment cultures were randomly assigned to groups with (n = 32) and without circumferential AIT (n = 32). Read More

Eye (Lond) 2020 May 4. Epub 2020 May 4.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, PR China.

Objectives: To evaluate the long-term outcome of patients with iridocorneal endothelial (ICE) syndrome who underwent Ahmed glaucoma valve implantation surgery for uncontrolled glaucoma.

Methods: Eighteen patients who suffered from unilateral ICE syndrome with uncontrolled glaucoma and subsequently underwent Ahmed aqueous shunt surgery at Zhongshan Ophthalmic Center between January 2008 and December 2016 were reviewed. Outcome measures included intraocular pressure (IOP), the use of glaucoma medications, visual acuity, further surgical interventions, and surgical complications. Read More

Ann Thorac Surg 2020 Apr 29. Epub 2020 Apr 29.

Department of Cardiovascular Surgery, Saga University, Saga, Saga, Japan.

Isolated left ventricular noncompaction, where broad trabeculae and deep intertrabecular recesses are observed in the left ventricular myocardium resulting from an arrest in normal embryogenesis, is a rare cardiomyopathy. We present the first report on isolated trabeculectomy and postoperative echocardiographic follow-up showing the recovery of the cardiac function for isolated left ventricular noncompaction. Read More

BMC Ophthalmol 2020 May 1;20(1):172. Epub 2020 May 1.

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI, 48105, USA.

Background: The surgical management of glaucoma associated with Axenfeld-Rieger Syndrome (ARS) is poorly described in the literature. The goal of this study is to compare the effectiveness of various glaucoma surgeries on intraocular pressure (IOP) management in ARS.

Methods: Retrospective cohort study at a university hospital-based practice of patients diagnosed with ARS between 1973 and 2018. Read More

Acta Ophthalmol 2020 Apr 30. Epub 2020 Apr 30.

Department of Ophthalmology, Rigshospitalet-Glostrup, Copenhagen, Denmark.

Purpose: Favourable outcome after glaucoma surgery depends on proper control of the inflammatory response. Failing filtration bleb and consequently increased intraocular pressure is an important cause of continuous visual field deterioration after uncomplicated glaucoma surgery. The present systematic review and meta-analysis aimed to compare the effects of employing either Mitomycin C (MMC), 5-Fluoruracil (5-FU) or no anti-metabolite in needling revision of trabeculectomies. Read More

J Ophthalmol 2020 14;2020:5189179. Epub 2020 Apr 14.

Department of Ophthalmology with Pediatric Unit, St Barbara 5th Regional Hospital, Trauma Centre, Medykow Square 1, 41200 Sosnowiec, Poland.

Purpose: Long-term results of the patients with total LSCD, who had undergone keratolimbal allograft (KLAL) for limbal reconstruction followed by penetrating keratoplasty (PK).

Methods: The study analyzes surgical treatment of 43 eyes with severe ocular surface disorders. All subjects underwent KLAL to achieve suitable conditions for consecutive PK. Read More

Folia Med (Plovdiv) 2019 12;61(4):506-511

Medical University of Plovdiv, Plovdiv, Bulgaria.

Aim: To present 5 cases of late choroidal detachment occurring spontaneously in pseudophakic glaucomatous eyes with previous trabeculectomy before cataract surgery. We discuss the causes, risk factors, frequency, diagnostic methods, differential diagnosis, and treatment of this disease.

Materials And Methods: In the presented 5 cases the choroidal effusion is proved by ophthalmoscopy and echography. Read More

Ophthalmology 2020 Mar 4. Epub 2020 Mar 4.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: To describe visual field (VF) outcomes in the Tube Versus Trabeculectomy (TVT) Study.

Design: Cohort analysis of patients in a multicenter randomized clinical trial.

Participants: A total of 122 eyes of 122 patients, with 61 eyes in both the tube shunt and trabeculectomy groups. Read More

Ophthalmic Epidemiol 2020 Apr 24:1-9. Epub 2020 Apr 24.

Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.

To determine the trends in epidemiological data in patients with neovascular glaucoma (NVG) in Taiwan. The data were obtained from the 2016 version of the Longitudinal Health Insurance Database, which contains data on two million randomly sampled patients. Patients with NVG diagnostic codes were enrolled in this study, after which we separated the study population according to different time periods. Read More

Eur J Ophthalmol 2020 Apr 21:1120672120920225. Epub 2020 Apr 21.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

PLoS One 2020 20;15(4):e0231614. Epub 2020 Apr 20.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Objective: To compare surgical success, postoperative intraocular pressure and complication rates between trabeculectomy and XEN gelstent surgery in a cohort of glaucoma patients in a typical clinical setting.

Methods: A retrospective cohort study of consecutive patients with refractory open-angle glaucoma including patients who underwent either stand-alone XEN gelstent insertion with Mitomycin C or trabeculectomy with Mitomycin C between 2016 and 2018 at the University Eye Hospital Mainz, Germany. Primary outcome measure was the proportion of surgical success 1 year after surgery. Read More

Int Ophthalmol 2020 Apr 16. Epub 2020 Apr 16.

Ophthalmology Department, Başkent University, Ankara, Turkey.

Purpose: To evaluate alterations in corneal biomechanical properties before and 6 months after conventional trabeculectomy (TRAB) and Ahmed glaucoma valve (AGV) implantation.

Methods: Thirty-nine eyes of 39 patients were evaluated retrospectively. Complete ophthalmological examinations including evaluation of corneal biomechanical properties using the Ocular Response Analyzer were performed before and after 6 months postoperatively. Read More

PLoS One 2020 16;15(4):e0231360. Epub 2020 Apr 16.

Department of Ophthalmology, University of Würzburg, Würzburg, Germany.

Purpose: To investigate whether microsurgical excision of trabecular meshwork (TM) in an ex vivo pigmentary glaucoma model can normalize the hypertensive phenotype.

Methods: Eight eyes of a porcine pigmentary glaucoma model underwent 90° of microsurgical TM excision with an aspirating dual-blade (Goniotome (G)). 24 hours later, additional 90° of TM were removed. Read More

Graefes Arch Clin Exp Ophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Purpose: The primary objective of the study was to assess the frequency and severity of visual field defects (VFD) in primary congenital glaucoma (PCG). The secondary objective was to ascertain any associated risk factors.

Methods: An ambispective review of patients with PCG on follow-up with a 'target' intraocular pressure (IOP) of ≤ 15 mmHg. Read More

Am J Ophthalmol Case Rep 2020 Jun 31;18:100682. Epub 2020 Mar 31.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: Two diabetic case reports of serous retinal detachment (SRD) accompanied by pachychoroid in hypotony maculopathy after trabeculectomy for neovascular glaucoma (NVG).

Observations: Case 1: A 66-year-old female with stage 3 NVG and decreased vision acuity in the left eye. After trabeculectomy, postoperative laser suture lysis (LSL) resulted in development of hypotony maculopathy, followed by pachychoroid and SRD. Read More

J Ophthalmol 2020 23;2020:1723691. Epub 2020 Mar 23.

Department of Ophthalmology, Shijiazhuang No. 1 Hospital, Hebei 050000, China.

Purpose: To compare long-term effects of trabeculectomy on pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG).

Methods: This retrospective case-control study included 53 eyes of PXG and 76 eyes of POAG. Intraocular pressure (IOP), number of antiglaucoma medications used, surgical success rate, and occurrence of complications were observed and statistically analyzed in both groups at 3 and 6 months and at 1, 3, and 5 years after trabeculectomy. Read More

Eur J Ophthalmol 2020 Apr 13:1120672120914491. Epub 2020 Apr 13.

St. Johannes Hospital, Eye Clinic, Dortmund, Germany.

Purpose: To estimate a risk-benefit ratio by comparing the efficacy of canaloplasty to trabeculectomy exclusively in pseudophakic eyes with primary open angle glaucoma.

Patients And Methods: One hundred four eyes that underwent canaloplasty and 136 eyes that underwent trabeculectomy with mitomycin C 0.02% and collagen matrix implantation were retrospectively compared. Read More

Int Ophthalmol 2020 Apr 11. Epub 2020 Apr 11.

Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Purpose: To evaluate the safety and efficacy profile of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma with a history of previous failed trabeculectomy surgery.

Method: This case-series study included 26 eyes of 26 consecutive patients with a mean age of 64.1 ± 4. Read More

Hum Genet 2020 Apr 9. Epub 2020 Apr 9.

Área de Genética, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain.

Abnormal development of the ocular anterior segment may lead to a spectrum of clinical phenotypes ranging from primary congenital glaucoma (PCG) to variable anterior segment dysgenesis (ASD). The main objective of this study was to identify the genetic alterations underlying recessive congenital glaucoma with ASD (CG-ASD). Next-generation DNA sequencing identified rare biallelic CPAMD8 variants in four patients with CG-ASD and in one case with PCG. Read More

J Cell Mol Med 2020 May 8;24(9):5195-5204. Epub 2020 Apr 8.

GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India.

Prostaglandin analogues (PG), beta-blockers (BB) or their combination (PG+BB) are used primarily to reduce the intraocular pressure (IOP) pathologically associated with glaucoma. Since, fibrosis of the trabecular meshwork (TM) is a major aetiological factor in glaucoma, we studied the effect of these drugs on fibrosis-associated gene expression in TM of primary glaucoma patients. In the present study, TM and iris of primary open-angle (n = 32) and angle-closure (n = 37) glaucoma patients were obtained surgically during trabeculectomy and categorized based on the type of IOP-lowering medications use as PG, BB or PG+BB. Read More

BMJ Open Ophthalmol 2020 24;5(1):e000423. Epub 2020 Mar 24.

Department of Vitreoretinal Surgery, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background/aims: To analyse the complications and outcomes of vitrectomy surgery for endophthalmitis.

Methods: This was a retrospective case series. All cases that underwent 23-gauge vitrectomy surgery for endophthalmitis at a tertiary centre between 1 February 2013 and 1 February 2018 were included. Read More

Vestn Oftalmol 2020 ;136(1):36-41

S.N. Fyodorov National Medical Research Center "MNTK "Eye Microsurgery", 59A Beskudnikovsky Blvd., Moscow, Russian Federation, 127486.

The universally established method for effective and less-invasive reduction of the intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG) is a two-step method consisting of non-penetrating deep sclerectomy (NDSE) followed by laser goniopuncture of the Descemet's membrane (Descemet's goniopuncture; DGP). However, the hypotensive effect can diminish at different times during the follow-up due to excessive scarring in surgically formed outflow tracts (SFOT).

Purpose: To evaluate the condition of SFOT in dynamics with Visante OCT after one-step combined laser technique consisting of modified selective laser activation of the trabecula (MSLAT) and DGP in advanced POAG patients with normalized IOP who have pronounced pigmentation of the trabecular meshwork and stage II pseudoexfoliation syndrome (PES). Read More

Vestn Oftalmol 2020 ;136(1):17-24

Ophthalmological Center of the Federal Medical-Biological Agency of the Russian Federation, A.I. Burnazyan Federal Medical and Biophysical Center of FMBA, 15 Gamalei St., Moscow, Russian Federation, 123098.

Purpose: To study the changes in central corneal thickness (CCT) and corneal hysteresis (CH) after selective laser trabeculoplasty (SLT) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) after laser peripheral iridotomy (LPI) and to determine their effect on the prognosis of the surgery.

Material And Methods: The prospective study involved 68 eyes with initial PACG after LPI and 74 eyes with initial POAG observed for 6 months. Corneal-compensated IOP (IOPcc), corneal resistance factor (CRF), CH and CCT were studied as the predictors of SLT, which was considered successful when IOPcc decreased by 20% or more from the baseline without additional hypotensive therapy and/or repeated SLT. Read More

J Nippon Med Sch 2020 Mar 31. Epub 2020 Mar 31.

Department of Ophthalmology, Nippon Medical School.

Purpose: The aim of this study was to measure the serum levels of brain-derived neurotrophic factor (BDNF) in primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients in Japan.

Methods: This was a prospective, observational study that examined serum BDNF levels in 78 patients who underwent cataract surgery or trabeculectomy (27 glaucoma patients and 51 non-glaucoma cataract patients as controls). The patients' age was 68. Read More

Laeknabladid 2020 04;106(4):187-192

University of Iceland, Ophthalmology department of Landspitali University Hospital, Iceland.

Introduction: Glaucoma is a degenerative disease in the optic nerve with associated visual field defects (VFD). Trabeculectomy is the most common glaucoma surgery. Surgery is indicated if glaucomatous optic neuropathy progresses despite tolerated medical treatment or in patients with severe VFD. Read More

Korean J Ophthalmol 2020 Apr;34(2):166-167

Department of Ophthalmology, Myung-Gok Eye Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.