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PLoS One 2019 20;14(3):e0209145. Epub 2019 Mar 20.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Purpose: To evaluate changes in the macula and peripapillary choroidal area at one year after trabeculectomy in order to determine the effect of intraocular pressure (IOP) changes.

Methods: This prospective longitudinal study examined 30 eyes of 30 patients with glaucoma that was uncontrolled by medical therapy. At 1 day before and at 1 year after the trabeculectomy surgery, macular and peripapillary choroidal images were recorded by enhanced depth imaging optical coherence tomography (EDI-OCT). Read More

PLoS One 2019 19;14(3):e0213811. Epub 2019 Mar 19.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Purpose: To investigate the potential of colchicine to improve bleb function after trabeculectomy.

Methods: To find the maximum usable colchicine concentration, an ocular irritation study was performed with the Draize test at concentrations of 0.001%, 0. Read More

Ophthalmol Ther 2019 Mar 16. Epub 2019 Mar 16.

Glaucoma Service, Hospital San Juan de Dios, Santiago, Chile.

Introduction: The aim of this study was to evaluate the efficacy of trabeculectomy with suprachoroidal derivation in eyes with uncontrolled glaucoma after a 24-month follow-up period.

Methods: This was a prospective uncontrolled non-randomized case series. All patients scheduled for a trabeculectomy due to uncontrolled glaucoma at the "Instituto de Glaucoma y Catarata" (Lima, Peru) between 2011 and 2014 were included. Read More

BMC Ophthalmol 2019 Mar 12;19(1):75. Epub 2019 Mar 12.

Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: The objective of this study is to evaluate and compare the short-term efficacy and safety of Ex-PRESS® mini shunt surgery and trabeculectomy for neovascular glaucoma (NVG).

Methods: Patients with NVG who underwent Ex-PRESS® mini shunt surgery or trabeculectomy as a primary glaucoma surgery between March 2013 and October 2015 were included in the study, and their medical charts were retrospectively reviewed. The Ex-PRESS® and trabeculectomy groups included 14 eyes and 30 eyes, respectively. Read More

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

University of Alabama at Birmingham Callahan Eye Hospital, Birmingham, USA.

Purpose: To describe the first known case of Bacteroides spp. related blebitis, keratitis, and endophthalmitis following uncomplicated trabeculectomy METHODS:: Case report and literature review CASE: A: 63-year-old immunocompetent white male underwent uncomplicated trabeculectomy of his right eye. Two weeks later, a blebitis with adjacent keratitis was diagnosed, progressing over several days to endophthalmitis despite hourly topical fortified antibiotic therapy. Read More

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

Department of Ophthalmology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz Germany.

PRéCIS:: The closing limbal suture after trabeculectomy with a fornix-based conjunctival flap plays no critical role in the development of corneal astigmatism and intraocular pressure. A standard removal is not recommended.

Purpose: To investigate the effect of removal of the conjunctival suture after trabeculectomy with fornix-based conjunctival flap on corneal astigmatism, visual acuity, and intraocular pressure. Read More

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

Sri Sankaradeva Nethralaya, City-Guwahati, State Assam, Pin code- 781028, India.

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

Department of Ophthalmology, University of Washington, Seattle, WA.

J Cataract Refract Surg 2019 Mar;45(3):312-320

Glaukos Corp., San Clemente, California, USA.

Purpose: To assess 5-year outcomes after implantation of 1 trabecular microbypass stent during cataract surgery in eyes with open-angle glaucoma (OAG) or ocular hypertension.

Setting: Private ophthalmology clinic (AaM Augenklinik am Marienplatz, Munich, Germany).

Design: Prospective nonrandomized consecutive case series. Read More

J Med Case Rep 2019 Mar 7;13(1):64. Epub 2019 Mar 7.

Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Gastric cancer has a wide spectrum of clinical features, imaging manifestations, and pathology. Punctate calcifications in gastric cancer are infrequent but are usually found in mucinous adenocarcinoma. However, there have only been a few autopsy case reports describing the correlation between the radiology and pathology findings of calcified mucinous adenocarcinoma of the stomach. Read More

Zhonghua Yan Ke Za Zhi 2019 Mar;55(3):214-219

Department of Glaucoma & the Clinical Research Center, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, China.

To investigate the tear film stability after trabeculectomy and its relationship with bleb morphology using Optical Quality Analysis System Ⅱ (OQAS Ⅱ). A cross-sectional study. Glaucoma patients undergoing trabeculectomy in the Eye Hospital of Wenzhou Medical University from November 2011 to November 2016 were invited by telephone to perform optical quality, bleb photography, and break-up time examinations, and history of surgeries and medications was collected. Read More

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

PRéCIS:: Bleb needle revision with and without 5-FU showed similar success rates over the course of a long-term follow-up. A greater total number of needle revisions was identified as a risk factor for procedural failure.

Purpose: To investigate the efficacy and safety of bleb needle revision with adjunctive 5-fluorouracil (5-FU) subconjunctival injection in large-scaled patients with failing trabeculectomy bleb. Read More

Int Ophthalmol 2019 Mar 4. Epub 2019 Mar 4.

University Eye Hospital, University of Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Germany.

Purpose: The aim was to compare the postsurgical outcomes of trabeculectomy (TET) and transscleral cyclophotocoagulation (CPC) in a similar cohort of eyes diagnosed with primary open-angle glaucoma (POAG).

Materials And Methods: For this monocentric non-randomized retrospective comparative trial, the records of eyes which underwent TET or CPC between 2013 and 2016 at our institution for the treatment of POAG were reviewed. Parameters analyzed before surgery as well as 1 and 2-3 years afterwards were visual acuity (VA), intraocular pressure (IOP), mean defect (MD) of the visual field, number of glaucoma medications and the objective refraction using which the surgically induced astigmatism (SIA) was calculated. Read More

J Glaucoma 2019 Mar;28(3):e41-e43

Manchester Royal Eye Hospital, Manchester, United Kingdom.

Low intraocular pressure and hypotony secondary to overfiltration is a recognized complication after trabeculectomy, particularly when augmented with antimetabolites such as 5-fluorouracil and mitomycin C. The relatively recent introduction of minimally invasive glaucoma surgery such as the ab interno XEN 45 (Allergan, Ireland) subconjunctival gel implant has heralded a new era of glaucoma drainage surgery where postoperative complications may be less and surgical recovery quicker. However, any effective glaucoma filtering procedure will always carry the risk of inducing hypotony. Read More

Int J Ophthalmol 2019 18;12(2):226-234. Epub 2019 Feb 18.

Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Aim: To evaluate the outcome of the initial and the redo-surgeries for primary congenital glaucoma (PCG) correlated to its degree of severity.

Methods: A retrospective study involved patients with PCG presented between 2010 and 2018. Medical records were reviewed to assess the degree of the preoperative severity according to the intraocular pressure (IOP), corneal diameter and corneal edema. Read More

J Glaucoma 2019 Feb 21. Epub 2019 Feb 21.

Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Precis: Rabbit model studies suggested better morphology blebs with equal IOP efficacy as a standard MMC Trabeculectomy using a novel slow release drug delivery anti-fibrotic system delivering small quantities of MMC and 5 FU.

Purpose: To evaluate two different concentrations of biodegradable poly(lactic-co-glycolic acid) (PLGA) system with 5-fluorouracil (5-FU) and mitomycin C (MMC) (ElutiGLASS) for their ability to reduce fibrosis and compare the results to standard trabeculectomy with MMC in a rabbit model.

Methods: New Zealand albino rabbits (19) were divided into 3 groups (A, B, C) and standard trabeculectomy operation was performed in the right eye of each rabbit. Read More

Clin Ophthalmol 2019 8;13:303-309. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA,

Purpose: This study evaluated US resident and fellow glaucoma surgical experience over a 7- and 8-year period, respectively.

Methods: US ophthalmology resident glaucoma case logs from 2009 to 2016 and glaucoma fellow case logs from 2008 to 2016 were reviewed. The number of total, average, median, and minimum cases, along with percentile data for filtering surgery, shunting surgery, and novel procedures were analyzed for year-to-year trends. Read More

Cochrane Database Syst Rev 2019 02 25;2:CD012741. Epub 2019 Feb 25.

Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, UK, EC1V 2PD.

Background: Glaucoma is a leading cause of irreversible blindness. A number of minimally invasive surgical techniques have been introduced as a treatment to prevent glaucoma progressing. Among them, endoscopic cyclophotocoagulation (ECP) is a cyclodestructive procedure developed by Martin Uram in 1992. Read More

Eur J Ophthalmol 2019 Feb 25:1120672119830861. Epub 2019 Feb 25.

1 Department of Ophthalmology, University Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Milan, Italy.

Purpose:: To evaluate the efficacy and safety of needle revision and examine factors predictive of failure.

Methods:: In total, 157 eyes of 131 patients that underwent needle revision augmented with either 5-fluorouracil or betamethasone for trabeculectomy failure were included in this retrospective study. Complete failure was defined as additional glaucoma surgery, ciliodestructive procedures, loss of light perception, sight-threatening complications, hypotony maculopathy, and surgical bleb revision. Read More

Br J Ophthalmol 2019 Feb 23. Epub 2019 Feb 23.

Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia

Aims: To report 15 cases of intraocular lens (IOL) calcification following intraocular surgery and to identify common risk factors.

Methods: A retrospective case review of patients with IOL calcification reported from the Royal Victorian Eye and Ear Hospital, Melbourne, Australia, and six surgeons in private practice in the Australian states of Victoria, New South Wales and Queensland.

Results: 15 cases of IOL calcification were identified. Read More

Clin Exp Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Glaucoma Investigation and Research Unit, Royal Victorian Eye and Ear Hospital, Centre for Eye Research, East Melbourne, Victoria, Australia.

Importance: Bleb-associated endophthalmitis is a potentially vision-threatening complication of trabeculectomy. With improvements in surgical technique and changing patterns of intraoperative antimetabolite use, a re-evaluation of the incidence of bleb-associated endophthalmitis is warranted.

Background: To investigate changes in the incidence, presentation, management and outcomes of bleb-associated endophthalmitis between 1997 and 2015 in Victoria, Australia. Read More

Invest Ophthalmol Vis Sci 2019 Feb;60(2):677-684

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Purpose: To investigate the effect of trabeculectomy on the waveform changes of laser speckle flowgraphy (LSFG) in the optic nerve head (ONH) in patients with glaucoma.

Methods: Forty-eight eyes of 48 patients with open angle glaucoma were included in this prospective study. LSFG was performed before and 1, 3, and 6 months after trabeculectomy. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Department of Ophthalmology, Hospital Universitario Príncipe de Asturias, Carretera Alcalá-Meco s/n, Alcalá de Henares, 28805, Madrid, Spain.

Purpose: The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls.

Methods: A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). Read More

Indian J Ophthalmol 2019 Mar;67(3):395-396

Department of Ophthalmology, Kalpana Chawla Government Medical College and Hospital, Karnal, Haryana, India.

Indian J Ophthalmol 2019 Mar;67(3):358-365

VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India.

Purpose: To describe the prevalence of various types of childhood glaucomas, their clinical features and treatment methods.

Methods: We prospectively included consecutive children with glaucoma presenting to glaucoma clinic for the first time between March 2013 and May 2014. We classified childhood glaucomas as per the classification proposed by Congenital Glaucoma Research Network. Read More

Eur J Ophthalmol 2019 Feb 17:1120672119827768. Epub 2019 Feb 17.

2 Eye Institute of Thrace, Democritus University of Thrace, Alexandroupolis, Greece.

Purpose:: To evaluate the outcomes of a new antiglaucoma surgical method, a modification of the standard deep sclerectomy, the penetrating deep sclerectomy.

Participants:: Patients with medically uncontrolled primary open-angle glaucoma or pseudoexfoliative glaucoma were prospectively, in a consecutive way, enrolled in this study.

Methods:: The study was conducted in Glaucoma Unit, Department of Ophthalmology, University of Hospital of Alexandroupolis, Greece, in 29 eyes of 29 patients. Read More

Med J Aust 2019 Mar 14;210(4):180-187. Epub 2019 Feb 14.

University of Sydney, Sydney, NSW.

Glaucoma is an irreversible progressive optic neuropathy, for which the major proven treatment is to lower the intraocular pressure (IOP). Five groups of IOP-lowering eye drops have varying mechanisms of action. Some drops, such as β-blockers and α-2 agonists, have potentially serious systemic side effects. Read More

Am J Ophthalmol Case Rep 2019 Jun 25;14:1-4. Epub 2019 Jan 25.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab.

Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG).

Methods: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Read More

J Ophthalmol 2019 14;2019:1585830. Epub 2019 Jan 14.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

Purpose: Bleb-related endophthalmitis (BRE) after glaucoma surgery is an infection caused by bacteria in the avascular bleb gaining access into the eye. We report the clinical features and outcome of 10 consecutive eyes with severe BRE treated at our hospital.

Methods: Ten patients (10 eyes) with stage IIIb BRE after trabeculectomy diagnosed and treated at the Department of Ophthalmology, Tokyo Medical University, between April 2013 and May 2015, were studied. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 9. Epub 2019 Feb 9.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: The minimally invasive ab-interno trabeculectomy (AIT) via electro-ablation with the Trabectome has been on the European market since 2009. Many studies have proven the safety and efficacy of the procedure. Up until now, studies investigating the long-term effect of AIT have been sparse. Read More

Klin Monbl Augenheilkd 2019 Feb 8. Epub 2019 Feb 8.

Augenabteilung am St. Franziskus-Hospital Münster.

Background: Trabeculectomy for the surgical reduction of internal eye pressure is an established procedure, but the principle limitations are in postoperative wound healing. Various antimetabolites are regularly used to avoid postoperative subconjunctival scarring. The present study investigates whether the combination of an Ologen implant with bevacizumab can modify the rates of success and/or complications during trabeculectomy. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Hospital Santa Maria, Av Prof. Dr. Egas Moniz, 1649-035, Lisbon, Portugal.

Purpose: This literature review and meta-analysis aims to compare intraocular pressure (IOP) lowering efficacy, failure rates and loss of light perception (LP) rates 6 months after an IOP-lowering surgical procedure in neovascular glaucoma (NVG) eyes.

Methods: MEDLINE and EMBASE were used as data sources. Only studies including NVG patients who underwent two different surgical approaches were considered. Read More

Invest Ophthalmol Vis Sci 2019 Feb;60(2):605-614

Institute for Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, United Kingdom.

Purpose: Surgical techniques such as trabeculectomy aim to treat glaucoma by making an incision into the scleral tissue, to create an alternative drainage pathway for aqueous to flow into the sub-Tenon's/subconjunctival space. However, tissue fibrosis and wound healing occurring after the procedures can reduce the success rate. This study aims to investigate the synergistic effects of aqueous humor in combination with shear stress on the fibrosis response occurring in Tenon's capsule and conjunctival tissue (TCCT) after glaucoma surgery. Read More

J Glaucoma 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology, Medical Faculty Carl Gustav Carus, Technische Universität, Fetscherstrasse 74, 01307 Dresden, Germany.

Purpose: To study the longitudinal correlation between the clinical morphological appearance of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in the early postoperative period.

Methods: Thirty eyes of 30 glaucoma patients scheduled for first-time trabeculectomy with mitomycin C 0.02% were consecutively enrolled. Read More

J Glaucoma 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.

Purpose: To identify the cross-sectional morphological changes in successful filtering blebs after phacoemulsification using swept-source three-dimensional anterior segment optical coherence tomography (3D AS-OCT).

Materials And Methods: Thirty phakic eyes of 29 patients with successful filtering blebs after primary trabeculectomy were included in this retrospective cohort study. Success was defined as intraocular pressure (IOP)≤15▒mmHg and a>20% reduction in IOP without glaucoma medication or additional glaucoma surgery after trabeculectomy. Read More

Int Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology, University of Nigeria Teaching Hospital, PMB 01129, Ituku-Ozalla, Enugu, Nigeria.

Purpose: To investigate the current practice on glaucoma care with the aim of highlighting its poise to tackle this emerging sight-threatening disease in Nigeria.

Methods: This was a cross-sectional, descriptive, population-based survey involving 88 ophthalmologists. Information on their demographic characteristics, practice profile, challenges and prospects on glaucoma care was collected using a semi-structured, self-administered questionnaire in August 2016. Read More

BMJ Open Ophthalmol 2018 22;3(1):e000183. Epub 2018 Dec 22.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, USA.

Objective: To describe the safety and effectiveness of CyPass supraciliary microstent implantation alone in eyes with open-angle glaucoma (OAG) followed up for up to 3 years.

Methods And Analysis: This registry study included subjects with primary or secondary OAG who underwent CyPass Micro-Stent implantation alone at 12 sites in four European countries to reduce intraocular pressure (IOP) and/or use of IOP-lowering medications. The primary safety outcome was the incidence of adverse events. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14128

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine.

To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365. Read More

Int Ophthalmol 2019 Jan 24. Epub 2019 Jan 24.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, 510060, China.

Purpose: To investigate the predictors of long-term intraocular pressure (IOP) in chronic primary angle-closure glaucoma (CPACG) treated with primary trabeculectomy.

Methods: This study systematically reviewed cases of CPACG treated with primary trabeculectomy. The scleral flaps in all cases were sutured with two stitches in situ and two releasable sutures to ensure watertight under normal IOP conditions during surgery. Read More

Indian J Ophthalmol 2019 Feb;67(2):287-289

Glaucoma Research Facility and Clinical Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

A 19-year-old female, having aniridia with secondary glaucoma, presented with uncontrolled intraocular pressure (IOP) in the right eye (RE) on maximal topical and systemic medications. On examination, RE had a subluxated cataractous lens with advanced cupping. She underwent trabeculectomy with mitomycin C. Read More

Indian J Ophthalmol 2019 Feb;67(2):285-287

Glaucoma Research and Clinical Facility, Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

A 45-year-old diabetic male, with diabetic retinopathy and medically uncontrolled neovascular glaucoma (NVG) underwent intracameral bevacizumab followed by trabeculectomy, with controlled intraocular pressures (IOP) post-operatively, OD: 12 mmHg; OS: 14 mmHg. Patient was referred to hematology, where he was diagnosed as chronic myeloid leukemia (CML) and started on imatinib mesylate. Thereafter, he presented with recurrence of neovascularization and vascularization of the bleb along with OS vitreous hemorrhage at 6 weeks follow-up. Read More

Indian J Ophthalmol 2019 Feb;67(2):217-220

Department of Ophthalmology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Purpose: Terminal chop, a new technique of nuclear segmentation, has been recently described in literature. The technique is considered to be a safe and effective option.

Methods: We did a retrospective study to evaluate the outcome of terminal chop. Read More

Asia Pac J Ophthalmol (Phila) 2019 Jan-Feb;8(1):3-7. Epub 2019 Jan 22.

Retina Unit, Sydney Eye Hospital, Sydney, NSW, Australia.

Purpose: To evaluate the efficacy and safety of early pars plana vitrectomy (PPV) for the treatment of acute infective endophthalmitis, and identify prognostic factors for better visual outcome.

Design: Retrospective cohort study.

Methods: Consecutive patients who underwent early PPV within 72 hours of presentation for the treatment of acute infective bacterial endophthalmitis and presented to a large tertiary referral center in New South Wales, Australia, between January 2009 and December 2013 were included. Read More

Niger J Clin Pract 2019 Jan;22(1):138-143

Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.

The aim of this study is to describe the effectiveness of trabeculectomy with mitomycin C and releasable suture in Posner-Schlossman syndrome (PSS) with secondary glaucoma. Early treatment is the key to successful management of PSS with secondary glaucoma. However, unremitting exposure of high intraocular pressure (IOP) because of the high recurrence rate of PSS may cause further optic nerve damage and visual field defect. Read More

BMC Ophthalmol 2019 Jan 21;19(1):24. Epub 2019 Jan 21.

Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, DHU Sight Restore, 28 rue de Charenton, 75012, Paris, France.

Background: The purpose of this study was to evaluate the changes in choroidal thickness and lamina cribrosa position after nonpenetrating deep sclerectomy (NPDS) and trabeculectomy.

Methods: Twenty-three eyes with glaucoma that required filtering surgery were included (12 NDPS and 11 trabeculectomies) in this prospective observational study. OCT-enhanced depth imaging (OCT-EDI) was used to measure choroidal thickness, prelaminar tissue thickness and lamina cribrosa position before and 7 days and 1 month after surgery. Read More

Harefuah 2019 Jan;158(1):60-64

Ophthalmology Department, Hillel Yaffe Medical Center.

Introduction: The goal of all glaucoma surgery is to lower eye pressure to prevent or reduce damage to the optic nerve. Standard glaucoma surgeries - trabeculectomy, ExPRESS shunts and external tube-shunts like the Ahmed and Baerveldt valves - are major surgeries. While they are very often effective at lowering eye pressure and preventing progression of glaucoma, they have a long list of potential complications. Read More

Int J Ophthalmol 2019 18;12(1):66-72. Epub 2019 Jan 18.

Department of Ophthalmology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China.

Aim: To evaluate whether the level of thrombospondin-1 (TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma (PACG).

Methods: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy (case group) and 78 age- and sex-matched patients with PACG who underwent successful trabeculectomy (control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-β2 levels with an enzyme-linked immunosorbent assay method. Read More

J Ophthalmol 2018 16;2018:5149154. Epub 2018 Dec 16.

Department of Ophthalmology, United Christian Hospital, Kowloon, Hong Kong.

Purpose: To compare the surgical outcome of combined phacoemulsification and endoscopic cyclophotocoagulation (phacoECP) versus combined phacoemulsification and mitomycin C-augmented trabeculectomy (phacoTbx) in patients with coexisting glaucoma and visually significant cataract.

Methods: A retrospective review of 89 eyes of 89 patients who received phacoECP (=49) and phacoTbx (=40) was carried out at a tertiary eye center in Hong Kong. The minimum follow-up period was 6 months. Read More

Ophthalmologe 2019 Jan 14. Epub 2019 Jan 14.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

The Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA, USA) is a novel goniotomy instrument for opening Schlemm's canal. Performing the procedure is comparable to the Trabectome (Neomedix, Tustin, CA, USA) under gonioscopic control with the major difference that the trabeculectomy is created by a dual blade instead of electroablation. The currently available clinical data are limited to a small number of retrospective studies with ≤1 year of follow-up. Read More