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Acta Ophthalmol 2021 May 4. Epub 2021 May 4.

Centro Internacional de Oftalmologia Avanzada, Madrid, Spain.

The formation of filtration blebs is the main drainage mechanism for reducing intraocular pressure after traditional incisional glaucoma surgery such as trabeculectomy and non-penetrating deep sclerotomy. Early and short-lasting blebs may also occur after canaloplasty. Bleb formation also plays an important role after the implantation of glaucoma drainage devices, including Minimally Invasive Glaucoma Surgery devices. Read More

Am J Ophthalmol Case Rep 2021 Jun 14;22:101088. Epub 2021 Apr 14.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: The aim of this report was to describe a case of cataract surgery and Descemet stripping automated endothelial keratoplasty (DSAEK) after cytomegalovirus (CMV) corneal endotheliitis and bullous keratopathy (BK) following immunosuppressive treatment for Mooren's ulcer.

Observations: A 64-year-old man was referred to our hospital because of peripheral ulcerative keratitis in his left eye. He had a history of trabeculectomy for open angle glaucoma in his left eye. Read More

BMJ Case Rep 2021 Apr 30;14(4). Epub 2021 Apr 30.

Jhaveri Microbiology Centre, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Cytomegalovirus (CMV) can cause recalcitrant recurrent keratouveitis and secondary glaucoma. We report a case of chronic recurrent anterior uveitis with secondary glaucoma presenting with acute visual loss and interface fluid 9 years after laser in situ keratomileusis. Based on clinical presentation, a viral aetiology was suspected. Read More

Br J Ophthalmol 2021 Apr 30. Epub 2021 Apr 30.

Ophthalmology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Purpose: To compare outcomes of primary trabeculectomy using either mitomycin C (MMC) alone versus MMC augmented with intracamerular bevacizumab in patients with open-angle glaucoma.

Methods: Retrospective, cohort, two-centre, comparative study. Patients' data were screened between October 2015 and March 2019, with inclusion requiring a minimum follow-up of 24 months. Read More

Br J Ophthalmol 2021 Apr 30. Epub 2021 Apr 30.

Ophthalmology Department, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, UK.

Background/aim: The aim of the study was to examine the effect of the COVID-19 pandemic on glaucoma surgical practices within the UK.

Methods: A cross-sectional online survey was distributed to all consultant glaucoma specialists who are on the UK and Eire Glaucoma Society contact list. Participants were asked specific questions regarding preferences in glaucoma surgical practices and whether these had changed subsequent to the onset of the COVID-19 pandemic. Read More

Klin Monbl Augenheilkd 2021 Apr 30;238(4):391-395. Epub 2021 Apr 30.

Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland.

Purpose: To evaluate the outcome of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma (OAG).

Participants And Methods: A retrospective case series of patients with uncontrolled OAG treated by GATT at the cantonal Hospital Lucerne, a tertiary referral center, between October 2018 and July 2019 with a minimal 6-month follow-up period. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, and complications. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Apr 30. Epub 2021 Apr 30.

Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan.

Purpose: To investigate how the central visual field would be changed after fornix-based trabeculectomy with mitomycin C in Japanese normal-tension glaucoma (NTG) patients monitored for more than 10 years including before surgery.

Methods: This is a retrospective cohort study. We identified twenty-eight eyes of 28 NTG cases regularly monitored for more than 5 years and examined static visual field (VF) tests for more than five times before and after fornix-based trabeculectomy (including combined surgery). Read More

J Clin Med 2021 Apr 12;10(8). Epub 2021 Apr 12.

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, 44037 Kaunas, Lithuania.

Dry eye disease causes ocular discomfort and visual disturbances. Older adults are at a higher risk of developing dry eye disease as well as needing for ophthalmic surgery. Anterior segment surgery may induce or worsen existing dry eye symptoms usually for a short-term period. Read More

J Clin Med 2021 Apr 10;10(8). Epub 2021 Apr 10.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Specific postoperative complications, such as tube exposure and conjunctival erosion, have occurred despite the favorable surgical outcomes of tube shunt surgeries for refractory glaucoma. The new autologous scleral pocket technique is performed by inserting the tube into the vitreous cavity without using a donor scleral patch. The purpose of this study was to evaluate the surgical results of Ahmed glaucoma valve (AGV) implantation using this technique for neovascular glaucoma (NVG), which is one of the representative refractory types of glaucoma. Read More

Indian J Ophthalmol 2021 May;69(5):1135-1141

Department of Ophthalmology, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

Purpose: Patients with glaucoma undergoing trabeculectomy develop bleb cicatrix causing poor postoperative intraocular pressure (IOP) control and low success rates. Several approaches have been explored over the years for better outcomes. This study assesses the safety, efficacy, and outcome of trabeculectomy with HealaFlow (Anteis S. Read More

Int J Appl Basic Med Res 2021 Apr-Jun;11(2):80-84. Epub 2021 Apr 8.

Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, India.

Background: Glaucoma is a serious vision-threatening condition appropriately called as the silent killer of sight. The effect of postoperative fibrosis on success of filtration surgeries requires modulation of the wound healing process.

Aim: The aim of the study was to compare trabeculectomy augmented with collagen matrix implant with mitomycin C in primary glaucoma. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Ophthalmology Department, Instituto de Investigación Sanitaria San Carlos (IdISSC), San Carlos Clinical Hospital, Madrid, Spain.

Purpose: To evaluate the efficacy and safety profile of Kahook Dual Blade ab interno trabeculectomy combined with phacoemulsification compared to stand-alone conventional cataract surgery.

Methods: A single-center longitudinal, randomized controlled trial was conducted. Patients older than 18 years with coexisting cataract and open-angle glaucoma or ocular hypertension were invited to participate. Read More

Retin Cases Brief Rep 2021 Apr 16. Epub 2021 Apr 16.

Department of Ophthalmology, University of Washington Eye Institute, 908 Jefferson St, 98104, Seattle, Washington, USA.

Purpose: To report a rare case of Abiotrophia defectiva bleb associated endophthalmitis (BAE).

Methods: In this case report of a patient with BAE, the authors describe the features of severe and rapid onset, associated retinitis, and a favorable outcome after aggressive early intervention.

Results: A 75-year old female presented that decreased visual acuity of hand motions with elevated intraocular pressure of 39 mm Hg in the left eye. Read More

J Cataract Refract Surg 2021 Jan;47(1):130

A 59-year-old man with mild to moderate pigmentary glaucoma was referred for management of hypotony-related maculopathy 3 years after combined phacoemulsification and trabeculectomy in his right eye. His ocular history is significant for retinal detachment in the right eye that was surgically treated with a pars plana vitrectomy and scleral buckle 5 years prior to the current presentation and 1 year prior to his combined phacoemulsification-trabeculectomy procedure. After trabeculectomy, he reportedly had a wound leak with hypotony and choroidal effusion. Read More

J Glaucoma 2021 May;30(5):e237-e245

Eye Department, Skaraborg Hospital, Skövde, Sahlgrenska Academy, University of Gothenburg and Karolinska Institute, Skövde, Sweden.

Prcis: In a Sweden-based study, a lower success rate in exfoliation than in open-angle glaucoma patients was found in a 5-year follow-up after trabeculectomy.

Purpose: The present study aimed to compare the success of trabeculectomies in exfoliation versus open-angle glaucoma patients.

Patients And Methods: Data were gathered through a retrospective chart review. Read More

Int Ophthalmol 2021 Apr 24. Epub 2021 Apr 24.

Department of Ophthalmology, Ningbo Eye Hospital, No. 599 Beimingcheng Road, Yinzhou District, Ningbo, 315000, Zhejiang Province, China.

Purpose: To compare the efficacy and security of conbercept and ranibizumab combined with trabeculectomy and panretinal photocoagulation for neovascular glaucoma (NVG).

Methods: One hundred and sixty patients with NVG were randomly divided into a conbercept group comprised of 80 patients and a ranibizumab group comprised of 80 patients. The postoperative and preoperative visual acuities, intraocular pressures frequency of anti-glaucoma medications, and surgical complications were recorded. Read More

BMC Ophthalmol 2021 Apr 24;21(1):188. Epub 2021 Apr 24.

Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Yoshida, 23-3 Simoaizuki, Matsuoka, Fukui, Japan.

Background: We aimed to compare the outcomes of trabeculectomy combined with phacoemulsification and those of trabeculectomy followed by phacoemulsification.

Methods: A total of 141 patients with primary open-angle glaucoma, exfoliation glaucoma, and glaucoma secondary to uveitis glaucoma who underwent trabeculectomy followed by (n = 48) or combined with (n = 93) phacoemulsification were included. We analyzed data collected from the Collaborative Bleb-Related Infection Incidence and Treatment Study, a prospective cohort study conducted in 34 clinical centers that included 1249 eyes. Read More

Eur J Ophthalmol 2021 Apr;31(1_suppl):16-19

Health Education KSS, East Surrey Hospital, Redhill, UK.

Introduction: Minimally invasive glaucoma surgery (MIGS) is a relatively new surgical technique available to glaucoma surgeons. The ab interno gelatin XEN stent (XEN®45, Allergan Inc., CA, USA) drains aqueous into the subconjunctival space and is theoretically less invasive than trabeculectomy and therefore carries less risk. Read More

Acta Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

The Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, Zhejiang, China.

Purpose: To report the efficacy and safety of bleb-independent penetrating canaloplasty in the management of primary angle-closure glaucoma (PACG).

Methods: This single-centre prospective interventional case series enrolled 57 eyes from 53 PACG patients with medically uncontrolled intraocular pressure (IOP) and peripheral anterior synechiae of over 270°. Penetrating canaloplasty, mainly consisted of tensioning suture-aided Schlemm's canal dilation and a trabeculectomy, was performed to create a direct communication between the anterior chamber and the Schlemm's canal. Read More

Int Ophthalmol 2021 Apr 21. Epub 2021 Apr 21.

Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: The aim of this study is to compare, using optical coherence tomography (OCT), the changes in the thickness of the macular nerve fiber layer (mNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL) and peripapillary global retinal nerve fiber layer (gRNFL) (in a span of 3 years) in surgically treated eyes with primary open-angle glaucoma (POAG).

Methods: The medical records of 32 consecutive POAG patients who underwent trabeculectomy with mitomycin-C, between January 2013 and December 2014, were retrospectively reviewed. Pre- and postoperative measurements of IOP and OCT were analyzed 1, 2 and 3 years after the operation. Read More

Acta Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

University of Iceland and Oculis ehf., Reykjavik, Iceland.

Using topical application to deliver therapeutic concentrations of drugs to the posterior segment of the eye remains very challenging. As a result, posterior segment diseases are usually treated by intravitreal injection or implant. While topical treatments are commonly used for anterior segment conditions, they sometimes require frequent applications. Read More

Int J Ophthalmol 2021 18;14(4):510-516. Epub 2021 Apr 18.

Department of Ophthalmology, Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Aim: To evaluate the safety and efficacy of augmented trabeculotomy with Ologen versus perfluoropropane in management of pseudophakic glaucoma.

Methods: This is a comparative randomized study included 57 pseudophakic eyes of 57 patients with medically uncontrolled open angle glaucoma (OAG). Twenty-nine patients were allocated in group I (trabeculectomy with Ologen; trab-ologen group), while 28 patients were assigned in group II (trabeculectomy with perfluoropropane gas bubble; trab-C3F8 gas bubble group). Read More

BMC Surg 2021 Apr 19;21(1):200. Epub 2021 Apr 19.

Stanley Eye Unit, Abergele Hospital, Llanfair Road, Abergele, Conwy, Wales, UK.

Background: Uveitic glaucoma commonly leads to a more intense optic nerve damage than other types of glaucoma, causing glaucomatous optic nerves and visual field defects. Anterior uveitis is the most commonly associated risk factor. Surgical intervention is usually indicated when all medical treatment has failed. Read More

J Curr Glaucoma Pract 2020 Sep-Dec;14(3):106-108

Department of Ophthalmology, University of California, Gavin Herbert Eye Institute, Irvine, California, USA; University of California, Irvine School of Medicine, Irvine, California, USA.

Purpose: To present an association between acquired pits of the optic nerve (APON) and prior laser-assisted keratomileusis (LASIK).

Materials And Methods: A retrospective case series of patients with an optic disc pit on clinical exam and a history of LASIK. Spectralis Optical Coherence Tomography images and Humphrey Visual Fields were reviewed from prior visits. Read More

J Curr Glaucoma Pract 2020 Sep-Dec;14(3):87-92

Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.

Aim: To compare outcomes of XEN gelatin stent (Allergan, Dublin, Ireland) implantation vs trabeculectomy with mitomycin C (MMC).

Materials And Methods: A retrospective review was conducted of eyes that underwent standalone XEN implantation or trabeculectomy with MMC at a single institution from 2014 to 2019. Intraocular pressure (IOP), visual acuity, glaucoma medications, complications, and postoperative interventions were evaluated. Read More

J Glaucoma 2021 Apr 15. Epub 2021 Apr 15.

Department of Ophthalmology University of Florida, Gainesville, FL The Edward Via College of Osteopathic Medicine, Spartanburg, South Carolina.

Prcis: A comparison of 186 glaucoma patients with mixed diagnoses who underwent non-valved glaucoma drainage implant surgery showed similar long-term IOP, medication, and VA outcomes between those with prior failed trabeculectomy surgery versus those without.

Purpose: To evaluate whether prior failed trabeculectomy adversely affects the outcome of glaucoma tube surgery.

Patients And Methods: 186 eyes of 186 patients who underwent a non-valved glaucoma drainage implant (GDD) surgery by a single surgeon between 1996 and 2015 at a University practice were included. Read More

Ophthalmol Glaucoma 2021 Apr 14. Epub 2021 Apr 14.

Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK; School of Health Professions (Faculty of Health), Plymouth, UK. Electronic address:

Eur J Ophthalmol 2021 Apr 16:11206721211010402. Epub 2021 Apr 16.

Department of Ophthalmology, Gulhane School of Medicine, University of Health Sciences, Ankara, Turkey.

A 13-year-old female patient with refractory primary congenital glaucoma (PCG) in the right eye who had a history of multiple glaucoma operations underwent ab interno 180-degree trabeculectomy with the Kahook Dual Blade (KDB) targeting the nasal and inferior angles. On postoperative day 1, the intraocular pressure (IOP) of the right eye reduced from 43 to 15 mmHg while on medical therapy. The patient maintained this IOP level throughout the 6-month follow-up. Read More

Eur J Ophthalmol 2021 Apr 15:11206721211009446. Epub 2021 Apr 15.

Department of Ophthalmology, Shri Jagdamba Charitable Eye Hospital, Sri Ganganagar, Rajasthan, India.

Background: The purpose of this paper is to delineate a technique of using a 23G, single, sutureless transconjunctival pars plana sclerotomy to facilitate anterior segment surgery in eyes with increased positive vitreous pressure (PVP) ascribe to predisposing or intraoperative factors.

Methods: We have implemented this technique in five eyes when PVP was anticipated before the surgery because of risk factors or it was encountered during anterior segment surgery. Different case scenarios in which PVP occurs during the surgery comprising phacolytic glaucoma, corneal tear repair combined with cataract surgery with IOL in a case with traumatic corneal injury, anterior capsule rupture and secondary glaucoma, Trabeculectomy in case of uveitic glaucoma, routine phacoemulsification cataract surgery with PVP encountered during surgery were addressed by using this technique. Read More

Klin Monbl Augenheilkd 2021 Apr 14;238(4):380-390. Epub 2021 Apr 14.

Klinik für Augenheilkunde, Sankt-Johannes-Hospital Dortmund, Dortmund, Germany.

Background: To report the efficacy of ab externo canaloplasty by exclusively using only a nonabsorbable suture as a standalone operation or combined with phacoemulsification in terms of mean intraocular pressure (IOP), medication reduction, and intra- and postoperative complication rates as well as additional glaucoma surgery.

Patients And Methods: Forty-eight patients with primary open-angle glaucoma (POAG) and 50 eyes were divided into two groups according to the operation performed (Group A canaloplasty, n = 34 and Group B canaloplasty combined with phaco, n = 16), respectively. The success criteria were evaluated between three IOP ranges: a) IOP ≤ 16 mmHg, b) ≤ 18 mmHg, and c) ≤ 21 mmHg. Read More