23,608 results match your criteria Toxoplasmosis


Utility of Neonatal Ophthalmologic Examination for Detection of Infectious Etiologies for Symmetric Intrauterine Growth Restriction.

J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Wills Eye Hospital, Philadelphia, PA; Cooper University Hospital, Camden, NJ.

Objective: To determine the utility of ophthalmologic examination as part of evaluation for infection in infants with intrauterine growth restriction (IUGR).

Study Design: This is a single-institution retrospective chart review of neonates diagnosed with symmetric IUGR or small for gestational age (SGA) who underwent complete ophthalmologic consultation to assess for intraocular findings suggestive of congenital infection. Data collected included other factors that may cause IUGR, findings of the general and ophthalmologic examination, and results of investigation for intrauterine infection. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.003DOI Listing

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.

Front Cell Infect Microbiol 2020 9;10:203. Epub 2020 Jun 9.

Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.

Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311950PMC

Unmasking of infectious retinitis and intraocular lymphoma in patients following uncomplicated dropless cataract surgery.

J Cataract Refract Surg 2020 May 27. Epub 2020 May 27.

From the Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

In this case series, 3 unique cases of severe immune-mediated pathologies (primary ocular lymphoma, toxoplasmosis chorioretinitis, and syphilitic retinitis) following dropless cataract surgery with intraocular steroid injection are reportd. Patient immune status and subsequent local immunosuppression following dropless cataract surgery played roles in the worsening of these pathologies. This report demonstrates the need for vigilance when administering immunosuppressive agents locally during cataract surgery. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000251DOI Listing

Molecular Detection of Toxoplasma Gondii in Haemaphysalis Ticks in Korea.

Korean J Parasitol 2020 Jun 26;58(3):327-331. Epub 2020 Jun 26.

Department of Environmental Medical Biology, Institute of Tropical Medicine, Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Seoul 03722, Korea.

Toxoplasma gondii are intracellular protozoa that can cause neurological disease or death in fetuses and even in immunocompromised human adults. Ticks are recognized as vectors of many microorganisms including viruses, bacteria, and protozoa. Recent studies detected T. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.3.327DOI Listing

Seroprevalence and B1 gene Phylogeny of Toxoplasma gondii of Dogs and Cats in Republic of Korea.

Korean J Parasitol 2020 Jun 26;58(3):257-265. Epub 2020 Jun 26.

Parasitic and Honeybee Disease Laboratory, Bacterial and Parasitic Disease Division, Department of Animal & Plant Health Research, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.

The outbreak of human toxoplasmosis can be attributed to ingestion of food contaminated with Toxoplasma gondii. Toxoplasmosis recently increased in domestic and stray dogs and cats. It prompted studies on the zoonotic infectious diseases transmitted via these animals. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.3.257DOI Listing

The congenital toxoplasmosis burden in Brazil: Systematic review and meta-analysis.

Acta Trop 2020 Jun 29;211:105608. Epub 2020 Jun 29.

Pathology Laboratory, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil.

Congenital toxoplasmosis is a zoonosis caused by the intracellular Apicomplexa protozoan Toxoplasma gondii. This infection causes subclinical or clinical lesions, such as retinochoroiditis and central nervous system lesions. The severity of fetal infection is related to the stage of pregnancy and the efficacy of the gestational treatment on fetal infection, whether it is achieved, or if it starts early. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105608DOI Listing

Chronic toxoplasmosis and sleepiness in obstructive sleep apnea: Is there a link?

PLoS One 2020 1;15(7):e0235463. Epub 2020 Jul 1.

Inserm, CHU Grenoble Alpes, HP2, University Grenoble Alpes, Grenoble, France.

Introduction: Sleepiness is the main clinical expression of obstructive sleep apnea (OSA) syndrome resulting from upper airway collapse. Recent studies have discussed the fact that the presence of T. gondii cysts in the brain and the resulting biochemical and immunological mechanisms could be linked to neurobehavioral disorders. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235463PLOS

Serological prevalence of Toxoplasma gondii infection in cats (Belém, Pará, Brazil).

Rev Bras Parasitol Vet 2020 26;29(2):e022719. Epub 2020 Jun 26.

Laboratório de Zoonoses e Saúde Pública, Faculdade de Medicina Veterinária, Instituto de Medicina Veterinária, Universidade Federal do Pará - UFPA, Castanhal, PA, Brasil.

We evaluated the prevalence of anti-Toxoplasma gondii antibodies in the serum samples collected from domestic cats in Belém, Pará, Brazil. We also correlated the presence of T. gondii antibodies with environmental variables and cat-owner habits. Read More

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http://dx.doi.org/10.1590/S1984-29612020038DOI Listing

The molecular biology and immune control of chronic Toxoplasma gondii infection.

J Clin Invest 2020 Jul;130(7):3370-3380

Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have been described to date, and it is estimated that 30% of the global human population is chronically infected. Read More

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http://dx.doi.org/10.1172/JCI136226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324197PMC

Prospective study of serum and aqueous humor anti-Hsp70.1 IgG antibody levels in ocular toxoplasmosis.

Parasite Immunol 2020 Jun 30:e12771. Epub 2020 Jun 30.

Univ. Grenoble Alpes, CNRS, INSERM, CEA, Institute of Interdisciplinary Research of Grenoble (IRIG), Laboratory of Biology of Cancer and Infection, CEA- 38000, Grenoble, France.

Aims: We evaluate whether the serum and aqueous humor (AH) level of IgG anti-Hsp70.1 antibodies improved the biological diagnosis of ocular toxoplasmosis.

Methods And Results: In this prospective cross-sectional and multicentre study, serum and AH were collected at the time of active uveitis. Read More

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http://dx.doi.org/10.1111/pim.12771DOI Listing

Prevalence of toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH) infections among women attending the antenatal care clinic, maternity hospital in Abha, Southwestern Saudi Arabia.

Saudi Med J 2020 Jul;41(7):757-762

Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. E-mail.

Objectives: To investigate the presence of toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH) infections in women attending at the antenatal care clinic in Abha, Kingdom of Saudi Arabia (KSA). Methods: A total of 190 blood samples were collected from Abha maternity hospital in Aseer region, KSA, from February 2018 to May 2019 and screened with the TORCH panel (toxoplasmagondii [IgG/IgM], cytomegalovirus [CMV] [IgG/IgM], rubella [IgG/IgM], and herpes simplex type 1 and 2 [IgG/IgM]).

Results: The mean age was 31. Read More

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http://dx.doi.org/10.15537/smj.2020.7.25121DOI Listing
July 2020
0.554 Impact Factor

Genetic polymorphism in IL17RA induces susceptibility to Toxoplasma gondii infection in Brazilian pregnant.

Acta Trop 2020 Jun 26:105594. Epub 2020 Jun 26.

Laboratory of Malaria and Toxoplasmosis Biology/LABMAT, Department of Microbiology and Parasitology. Electronic address:

Congenital toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, an obligate intracellular parasite which can cause fetal death/abortion and can induce damage in the brain and eyes of the infected babies. The environmental and genetic factors associated with T. gondii and the maternal immune response, drive part of the pathogenesis of congenital toxoplasmosis. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105594DOI Listing

Identifying the Target of an Antiparasitic Compound in Using Thermal Proteome Profiling.

ACS Chem Biol 2020 Jul 6. Epub 2020 Jul 6.

Department of Biology, Massachusetts Institute of Technology, 30 Ames St, Cambridge, Massachusetts 02142, United States.

Apicomplexan parasites include the causative agents of malaria and toxoplasmosis. Cell-based screens in previously identified a chemical modulator of calcium signaling (ENH1) that blocked parasite egress from host cells and exhibited potent antiparasitic activity. To identify the targets of ENH1, we adapted thermal proteome profiling to , which revealed calcium-dependent protein kinase 1 (CDPK1) as a target. Read More

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http://dx.doi.org/10.1021/acschembio.0c00369DOI Listing

Seroepidemiology of ovine toxoplasmosis and neosporosis in breeding rams from Rio Grande do Sul, Brazil.

Transbound Emerg Dis 2020 Jun 29. Epub 2020 Jun 29.

Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Brazil.

This study determined the prevalence of ovine toxoplasmosis and neosporosis and the risk factors associated with the development of these diseases in breeding rams from the State of Rio Grande do Sul (RS), Southern Brazil. Serum samples (n = 1,800) from breeding rams maintained on 705 sheep farms from seven mesoregions were evaluated serologically to detect anti-IgG Toxoplasma gondii by indirect ELISA and anti-IgG Neospora caninum by the indirect immunofluorescence assay (IFA). The prevalence of T. Read More

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http://dx.doi.org/10.1111/tbed.13593DOI Listing

Serological Survey of and Co-Infection in Rodents in Northwestern Iran.

Iran J Parasitol 2020 Apr-Jun;15(2):253-258

Department of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Our knowledge of the epidemiology of rodents' parasitic agents in Iran is scarce, although some of these pathogens play an important role in human and veterinary medicine, such as and . The purpose of this study was to determine the seroprevalence of and in rodents of northwestern Iran between Mar and Dec 2015.

Methods: Overall, 157 serum samples from rodents (101 , 41 , and 15 ) were assayed by the indirect fluorescence antibody test (IFAT) for antibodies to and . Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311819PMC
June 2020
0.872 Impact Factor

Serological Evaluation of Anti- Antibodies in Patients with Acute Leukemia and Lymphoma through Chemotherapy.

Iran J Parasitol 2020 Apr-Jun;15(2):187-195

Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: is a protozoan parasite that belongs to the family Coccidae. We aimed to evaluate IgG avidity and the changes of anti- immunoglobulins M (IgM) and G (IgG) in patients with acute leukemia and lymphoma.

Methods: Ninety eight patients with Acute myeloid leukemia (AML), Acute Lymphoblastic Leukemia (ALL) and lymphoma, selected from patients referring to Imam Reza Hospital of Tabriz (38°04'N 46°18'E), in terms of the presence of anti- IgM, IgG, IgG avidity antibodies and the major risk factors were evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311818PMC

Isolation and Genotypic Characterization of Based on GRA6 Gene from Environmental Soil Samples in Mazandaran Province, North of Iran.

Iran J Parasitol 2020 Apr-Jun;15(2):158-167

Toxoplasmosis Research Center (TRC), Mazandaran University of Medical Sciences, Sari, Iran.

Background: Soil is one of the environmental sources of oocysts. The other hand, genotype of the parasite is one of the important factors for its pathogenicity. Due to the importance of toxoplasmosis on public health, this study aimed to isolation and genotyping of in environmental soil samples of Mazandaran Province, north of Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311813PMC

Editorial: Regulation of Immunity to Parasitic Infections Endemic to Africa.

Front Immunol 2020 12;11:1159. Epub 2020 Jun 12.

Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

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http://dx.doi.org/10.3389/fimmu.2020.01159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304307PMC

Cerebral toxoplasmosis associated with treatment with rituximab, azathioprine and prednisone for dermatomyositis.

Br J Clin Pharmacol 2020 Jun 27. Epub 2020 Jun 27.

Hospital pharmacy, Hospital San Cecilio, Granada, Spain.

We observed a severe case of cerebral toxoplasmosis in a 22-year-old woman diagnosed with dermatomyositis in 2016 in Venezuela, and treated with rituximab and azathioprine. The patient met clinical and microbiological. Treatment with pyrimethamine and sulfadiazine was initiated and the patient was discharged. Read More

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http://dx.doi.org/10.1111/bcp.14445DOI Listing

Association of Toxoplasma gondii infection with cardiovascular diseases: a cross-sectional study among patients with heart failure diseases in Urmia, North-West of Iran.

Ann Parasitol 2020 ;66(2):193-199

Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.

Toxoplasmosis is a disease caused by the protozoan parasite Toxoplasma gondii. Infection with T. gondii is one of the most common parasitic diseases in humans and other warm-blooded animals with global distribution and generally, one-third of human populations are estimated to be contaminated with this parasite. Read More

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http://dx.doi.org/10.17420/ap6602.254DOI Listing
January 2020

A case of congenital toxoplasmosis-associated miscarriage with maternal infection four months prior to conception.

Parasitol Int 2020 Jun 24;79:102165. Epub 2020 Jun 24.

Service de Parasitologie-Mycologie, CHU de Nice, Université Côte d'Azur, Nice, France; Inserm U1065, C3M, Nice, France.

Background: We report a case of fatal congenital toxoplasmosis with maternal infection dated four months before pregnancy in the absence of any specific immunosuppressive condition.

Case: Ms. D. Read More

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http://dx.doi.org/10.1016/j.parint.2020.102165DOI Listing

Seroprevalence and Risk Factors of Infection in Pregnant Women from Western Romania.

Vector Borne Zoonotic Dis 2020 Jun 24. Epub 2020 Jun 24.

Discipline of Parasitology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

Seroprevalence and risk factors of infection were assessed among pregnant women in Western Romania. seroprevalence was evaluated in 208 pregnant women by demonstration of serum antibodies using the commercial Vitros anti- immunoglobulin G (IgG) and IgM assays. A questionnaire was administered to obtain information regarding the risk factors associated with seropositivity. Read More

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http://dx.doi.org/10.1089/vbz.2019.2599DOI Listing

Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.

Arch Dis Child 2020 Jun 25. Epub 2020 Jun 25.

Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK.

Background: The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often limited, leading to missed diagnostic opportunities. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318841DOI Listing

NMR resonance assignments of the programmed cell death protein 5 (PDCD5) from Toxoplasma gondii.

Biomol NMR Assign 2020 Jun 23. Epub 2020 Jun 23.

Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.

Toxoplasmosis is a systematic protozoan disease caused by a tiny parasite Toxoplasma gondii. The infection can be dangerous for pregnant woman and people with weak immune systems. The secreted protein named TgPDCD5 (Programmed cell death protein 5 from Toxoplasma gondii) plays an important role in apoptosis-inducing effect on host cells. Read More

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http://dx.doi.org/10.1007/s12104-020-09961-8DOI Listing

Detection of in retail meat samples in Scotland.

Food Waterborne Parasitol 2020 Sep 12;20:e00086. Epub 2020 Jun 12.

Moredun Research Institute, Pentlands Science Park, Midlothian EH26 0PZ, UK.

is a globally important zoonotic parasite ranked as one of the most significant causes of disease burden among the major foodborne pathogens. Consumption of undercooked meat is a well-known risk factor for infection so the aim of this study was to investigate the presence of in meat samples from retail outlets in Scotland. In Sampling Period 1, 300 meat samples (39 beef, 21 chicken, 87 lamb, 71 pork and 82 venison) were purchased from butchers', farmers' markets, farm shops and supermarkets, and in Sampling Period 2, 67 pure venison samples only were purchased from farmers' markets, farm shops and supermarkets. Read More

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http://dx.doi.org/10.1016/j.fawpar.2020.e00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303546PMC
September 2020

The development and evaluation of a multi-epitope antigen as a serodiagnostic marker of Toxoplasma gondii infection.

Adv Clin Exp Med 2020 Jun;29(6):669-675

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Toxoplasma gondii (T. gondii) is a ubiquitous protozoan parasite which causes a serious disease called toxoplasmosis. The high prevalence of T. Read More

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http://dx.doi.org/10.17219/acem/104554DOI Listing

Evaluation of ursolic acid derivatives with potential anti-Toxoplasma gondii activity.

Exp Parasitol 2020 Jun 20;216:107935. Epub 2020 Jun 20.

Medical College of Dalian University, Dalian, 116622, China. Electronic address:

Toxoplasma gondii is an important pathogen that causes serious public health problems. Currently, therapeutic drugs for toxoplasmosis cause serious side effects, and more effective and novel substances with relatively low toxicity are urgently needed. Ursolic acid (UA) has many properties that can be beneficial to healthcare. Read More

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http://dx.doi.org/10.1016/j.exppara.2020.107935DOI Listing

Comparing spatio-temporal distribution of the most common human parasitic infections in Iran over two periods 2007 to 2012 and 2013 to 2018: A systematic quantitative literature review.

Int J Health Plann Manage 2020 Jun 22. Epub 2020 Jun 22.

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

This study analyses the spatio-temporal trend of the prevalence of the four most prevalent parasitic diseases in Iran over two periods, 2007 to 2012 and 2013 to 2018, indicating high-risk and low-risk areas. Out of 19 126 articles, we selected 220 articles for data extraction and calculated the pooled prevalence for cutaneous leishmaniasis, human toxoplasmosis, giardiasis and blastocystosis for all 31 provinces in the country. Anselin local Moran's I was used to identify clusters and outliers in the prevalence rates. Read More

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http://dx.doi.org/10.1002/hpm.3010DOI Listing

Seronegative ocular toxoplasma panuveitis in an immunocompetent patient.

Am J Ophthalmol Case Rep 2020 Sep 15;19:100745. Epub 2020 May 15.

Department of Ophthalmology, The University of Kansas School of Medicine, Kansas City, KS, USA.

Purpose: Toxoplasma gondii is the most common cause of infectious posterior uveitis worldwide in immunocompetent patients. Despite its prevalence, diagnosis can still be challenging and vision-threatening in cases with atypical presentations. This case exemplifies the importance of clinical exam and additional workup when required despite negative initial serology results. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296335PMC
September 2020

Duffy blood group system and ocular toxoplasmosis.

Infect Genet Evol 2020 Jun 19;85:104430. Epub 2020 Jun 19.

Faculdade de Medicina de São Jose do Rio Preto, SP, Brazil. Electronic address:

Duffy blood group phenotypes [Fy(a + b-), Fy(a-b+), Fy(a + b+), Fy(a-b-)], characterized by the expression of Fy, and Fy antigens, are present in red blood cells. Therefore, we hypothesize that the non-hematopoietic expression of these antigens might influence cell invasion by T. gondii. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104430DOI Listing

Implementation and analysis of Babesia immunoassay testing.

Pol Merkur Lekarski 2020 Jun;48(285):170-173

Kharkiv National Medical University, Kharkiv, Ukraine.

Lifelong withdrawal from the donor population of those who have been diagnosed with babesiosis must be used for transmission prevention.

Aim: The aim of the study was a detection of Babesia antibodies level with the usage of experimental Babesia divergens whole-cell slide antigen and commercial B. microti immunofluorescence assay substrate slide (Fuller Laboratories, USA). Read More

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Acute Perinatal Infection and the Evidenced-Based Risk of Intrauterine Diagnostic Testing: A Structured Review.

Authors:
R Douglas Wilson

Fetal Diagn Ther 2020 Jun 19:1-12. Epub 2020 Jun 19.

Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary/Alberta Health Services, Calgary, Alberta, Canada,

Background: The prevalence of perinatal infection from maternal exposure is increasing. The prevalence of acute maternal infections identifies cytomegalovirus, parvovirus B19, toxoplasmosis, and varicella as the most common organisms and in the order of frequency. Maternal informed consent and understanding is required before intrauterine testing for fetal infectious and possible genetic risk assessment. Read More

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http://dx.doi.org/10.1159/000508042DOI Listing

Elevation of CSF adenosine deaminase in HIV patient with meningitis from retroviral rebound syndrome, a case report.

Int J Infect Dis 2020 Jun 17. Epub 2020 Jun 17.

Department of Infectious Diseases, Kobe City Medical Center General Hospital, Japan; Department of General Internal Medicine, Kobe City Medical Center General Hospital, Japan.

Adenosine deaminase (ADA) in cerebrospinal fluid (CSF) is considered to be a useful biomarker in differentiating tuberculous meningitis (TBM) from other meningitis in non-HIV patients. However, its specificity decreases in patients with HIV, and other diseases such as cytomegalovirus encephalitis, toxoplasmosis or meningeal lymphomatosis can also elevate ADA in CSF. We here report a rare case of retroviral rebound syndrome in a HIV patient, whose ADA in CSF was elevated. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.050DOI Listing

Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature.

Rev Bras Ginecol Obstet 2020 Jun 19. Epub 2020 Jun 19.

Departament of Gynecology and Obstetrics, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Objective:  The aim of the current review is to present a systematic evaluation of reported human placental findings in cases of zika virus (ZIKV) infection.

Data Sources:  We reviewed the EMBASE, PUBMED, and SCIELO databases until June 2019, without language restrictions.

Selection Of Studies:  The search terms AND were used. Read More

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http://dx.doi.org/10.1055/s-0040-1712126DOI Listing

Seroprevalence of Toxoplasma gondii Infection and Associated Factors in Sheep from Jalisco, Mexico.

J Parasitol 2020 Jun;106(3):392-394

Tecnológico Nacional de México, Instituto Tecnológico El Llano Aguascalientes, km 18 carretera Aguascalientes-San Luis Potosí, El Llano, 20330, Aguascalientes, México.

The objective of the study was to identify the seroprevalence of anti-Toxoplasma gondii antibodies in sheep herds from 3 municipalities from Jalisco, Mexico, as well as estimate the association between seroprevalence and certain factors presents in the farms. In total, 12 sheep farms that maintain only hair breeds were included in the work. From these farms, 336 blood samples were collected, corresponding 324 to ewes and 12 rams. Read More

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http://dx.doi.org/10.1645/19-176DOI Listing

Association between Toxoplasma gondii infection and headache: a systematic review and meta-analysis.

Infect Disord Drug Targets 2020 Jun 17. Epub 2020 Jun 17.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari. Iran.

Background: The impact of infectious agents, such as Toxoplasma gondii (T. gondii), on human behavior and mental disorders has recently attracted the attention of researchers. T. Read More

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http://dx.doi.org/10.2174/1871526520666200617135851DOI Listing

Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Infection.

Brain Sci 2020 Jun 12;10(6). Epub 2020 Jun 12.

GI en Neurociencias-NeURos, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111221, Colombia.

is an obligate intracellular parasite considered one of the most successful pathogens in the world, owing to its ability to produce long-lasting infections and to persist in the central nervous system (CNS) in most warm-blooded animals, including humans. This parasite has a preference to invade neurons and affect the functioning of glial cells. This could lead to neurological and behavioral changes associated with cognitive impairment. Read More

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http://dx.doi.org/10.3390/brainsci10060369DOI Listing

Ischemic stroke associated with novel coronavirus 2019: a report of three cases.

Int J Neurosci 2020 Jun 17:1-5. Epub 2020 Jun 17.

Neurology Department, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

There is limited evidence about the neurological manifestations of COVID-19 in infected patients. In this report, we describe three patients with ischemic stroke associated with COVID-19 infection. We report 3 cases of adult patients with ischemic stroke and novel coronavirus 2019 infection. Read More

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http://dx.doi.org/10.1080/00207454.2020.1782902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309300PMC

Efficacy of Guanabenz Combination Therapy Against Chronic Toxoplasmosis Across Multiple Mouse Strains.

Antimicrob Agents Chemother 2020 Jun 15. Epub 2020 Jun 15.

Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA

, an obligate intracellular parasite that can cause life-threatening acute disease, differentiates into a quiescent cyst stage to establish lifelong chronic infections in animal hosts, including humans. This tissue cyst reservoir, which can reactivate into an acute infection, is currently refractory to clinically available therapeutics. Recently, we and others have discovered drugs capable of significantly reducing brain cyst burden in latently infected mice, but not to undetectable levels. Read More

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http://dx.doi.org/10.1128/AAC.00539-20DOI Listing

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Brain Cysts.

Antimicrob Agents Chemother 2020 Jun 15. Epub 2020 Jun 15.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Toxoplasmosis is a potentially fatal infection for immunocompromised people and the developing fetus. Current medicines for toxoplasmosis have high rates of adverse effects that interfere with therapeutic and prophylactic regimens. Endochin-like quinolones (ELQs) are potent inhibitors of proliferation and in animal models of acute and latent infection. Read More

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http://dx.doi.org/10.1128/AAC.00535-20DOI Listing

Treatment with melatonin induces a reduction of Toxoplasma gondii development in LLC-MK2 cells.

Parasitol Res 2020 Jun 14. Epub 2020 Jun 14.

Laboratório de Tecnologia em Cultura de Células, Centro Universitário Estadual da Zona Oeste, Av. Manuel Caldeira de Alvarenga, 1203, Campo Grande, Rio de Janeiro, RJ, CEP: 23070-200, Brazil.

It is known that the current treatment for toxoplasmosis causes side effects. Thus, it is essential to develop new therapies with reduced adverse effects while concurrently maintaining broad coverage and prophylactic therapy. Melatonin is a hormone that participates in the circadian cycle in vertebrates and has antioxidant, immunomodulatory, and antitumoral functions. Read More

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http://dx.doi.org/10.1007/s00436-020-06766-5DOI Listing

Seroprevalence and risk factors associated with infection in sheep of Veracruz State, southeast Mexico.

Vet Res Forum 2020 15;11(1):77-81. Epub 2020 Mar 15.

Faculty of Biological and Agricultural Sciences, Universidad Veracruzana , Córdoba, Mexico.

is widely prevalent in sheep and their products pose a risk to public health. The aim of this study was to identify the seroprevalence and risk factors associated with infection in sheep in Veracruz State, Mexico. The study was cross-sectional and it was carried out in thirteen municipalities distributed in three regions of Veracruz State. Read More

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http://dx.doi.org/10.30466/vrf.2019.96751.2313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282216PMC

Congenital toxoplasmotic chorioretinitis following reinfection.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 19. Epub 2020 Apr 19.

Department of General Surgery and Medical Surgical Specialities, University of Catania, Catania, Italy.

Toxoplasmosis does not usually give any symptoms to a pregnant woman and in most cases she does not realize to be infected. On the contrary, in the newborn, congenital toxoplasmosis can be responsible of hydrocephalus, microcephaly, intracranial calcifications, strabismus, blindness, epilepsy, mental retardation, thrombocytopenia, anemia and chorioretinitis. All these pathologies have been reported in the primary infection, while they are unusual in either reinfections or recurrences. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.04.045DOI Listing

[PECULIARITIES OF INTERACTION IN THE "PARASITE-HOST" SYSTEM IN HIV-INFECTED PATIENTS WITH TOXOPLASMOSIS: LITERATURE AND CLINICAL CASE REVIEW].

Georgian Med News 2020 Apr(301):130-136

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russia.

The article presents a review of current literature data on the development of opportunistic toxoplasmosis in patients suffering from HIV infection and a clinical case of an immunocompromised patient with toxoplasmosis. Current information concerning the incidence of toxoplasmosis in Russia and other countries are presented. Special attention is paid to the Toxoplasma gondii interactions with the host cell in HIV-infected people. Read More

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Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients.

Acta Parasitol 2020 Jun 12. Epub 2020 Jun 12.

Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Purpose: Immunocompromised patients may be at risk for reactivation of the toxoplasmosis infection, because of defection in cell-mediated immunity. Therefore, early diagnosis would be highly desirable in these individuals. This case-control study was designed to increase information about toxoplasmosis in hemodialysis (HD) patients in Guilan province, Iran. Read More

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http://dx.doi.org/10.1007/s11686-020-00238-7DOI Listing

Antileishmanial and antibacterial activities of the hydroalcoholic extract of Rhus coriaria L.

Ann Parasitol 2020 ;62(2):157-163

Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences; Km 18 of Khazarabad road, Sari, Iran.

Leishmaniosis is one of the most serious public health concern with a worldwide distribution. Since the current treatments of leishmaniosis are toxic and expensive, frequent studies have been conducted to investigate the benefits of new resources such as medicinal plants for treatment of this infectious disease. Recent studies revealed the antiparasitic potential of Rhus coriaria. Read More

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http://dx.doi.org/10.17420/ap6602.250DOI Listing
January 2020

Supply and demand-heme synthesis, salvage and utilization by Apicomplexa.

FEBS J 2020 Jun 12. Epub 2020 Jun 12.

Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Switzerland.

The Apicomplexa phylum groups important human and animal pathogens that cause severe diseases, encompassing malaria, toxoplasmosis, and cryptosporidiosis. In common with most organisms, apicomplexans rely on heme as cofactor for several enzymes, including cytochromes of the electron transport chain. This heme derives from de novo synthesis and/or the development of uptake mechanisms to scavenge heme from their host. Read More

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http://dx.doi.org/10.1111/febs.15445DOI Listing

Crossing the Vacuolar Rubicon: Structural Insights into Effector Protein Trafficking in Apicomplexan Parasites.

Authors:
Pascal F Egea

Microorganisms 2020 Jun 8;8(6). Epub 2020 Jun 8.

Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Apicomplexans form a large phylum of parasitic protozoa, including the genera , and , the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively. They cause diseases not only in humans but also in animals, with dramatic consequences in agriculture. Most apicomplexans are vacuole-dwelling and obligate intracellular parasites; as they invade the host cell, they become encased in a parasitophorous vacuole (PV) derived from the host cellular membrane. Read More

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http://dx.doi.org/10.3390/microorganisms8060865DOI Listing

Description of an atypical Toxoplasma gondii isolate from a case of congenital toxoplasmosis in northeastern Brazil.

Parasitol Res 2020 Jun 10. Epub 2020 Jun 10.

Department of Veterinary Medicine, Laboratory of Infectious-Contagious Diseases of Domestic Animals, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.

We report a case of severe congenital toxoplasmosis that involved an atypical T. gondii genotype in a newborn baby from Alagoas state in Northeastern Brazil. A pregnant woman presented IgM and IgG anti-T. Read More

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http://dx.doi.org/10.1007/s00436-020-06746-9DOI Listing

Occurrence of antibodies and associated risk factors in women in selected districts of Punjab province, Pakistan.

Parasitology 2020 Jun 10:1-7. Epub 2020 Jun 10.

Department of Biosciences, COMSATS University Islamabad, Park Road, Chakh Shahzad, Islamabad, Pakistan.

Toxoplasmosis is a parasitic zoonotic disease caused by Toxoplasma (T.) gondii. Limited data are available on the occurrence of T. Read More

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http://dx.doi.org/10.1017/S0031182020000967DOI Listing
June 2020
2.560 Impact Factor