22,443 results match your criteria Toxoplasmosis


Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group.

Pathogens 2019 Feb 18;8(1). Epub 2019 Feb 18.

Assistance Publique-Hôpitaux de Marseille, Department of Neonatal Medicine; Hospital of the Conception, 13005 Marseille, France.

Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. Read More

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http://dx.doi.org/10.3390/pathogens8010024DOI Listing
February 2019

hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye.

Int J Mol Sci 2019 Feb 16;20(4). Epub 2019 Feb 16.

Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.

Human retinal pigment epithelial (hRPE) cells are important for the establishment and maintenance of the immune privilege of the eye. They function as target cells for human cytomegalovirus (hCMV), but are able to restrict viral replication. hCMV causes opportunistic posterior uveitis such as retinitis and chorioretinitis. Read More

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http://dx.doi.org/10.3390/ijms20040858DOI Listing
February 2019

Detection of Toxoplasma gondii B1 Gene and IgM in IgG Seropositive Pregnant Women.

Clin Lab 2019 Jan;65(1)

Background: The onset of acute toxoplasmosis in pregnant women may pose a risk to their growing fetuses. The timely diagnosis of infection in managing the disease and preventing its harmful consequences on the fetus is very important. Therefore, the study was conducted to identify acute toxoplasmosis in the pregnant women by detecting the specific IgM antibody and Toxoplasma gondii B1 gene. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180425DOI Listing
January 2019

Rhoptry antigens as vaccine target.

Clin Exp Vaccine Res 2019 Jan 31;8(1):4-26. Epub 2019 Jan 31.

Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Toxoplasmosis is a cosmopolitan zoonotic infection, caused by a unicellular protozoan parasite known as that belongs to the phylum Apicomplexa. It is estimated that over one-third of the world's population has been exposed and are latently infected with the parasite. In humans, toxoplasmosis is predominantly asymptomatic in immunocompetent persons, while among immunocompromised individuals may be cause severe and progressive complications with poor prognosis. Read More

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http://dx.doi.org/10.7774/cevr.2019.8.1.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369123PMC
January 2019

Protein O- and C-Glycosylation pathways in Toxoplasma gondii and Plasmodium falciparum.

Parasitology 2019 Feb 18:1-12. Epub 2019 Feb 18.

Department of Clinical Biochemistry OE4340,Hannover Medical School,Carl-Neuberg-Strasse 1, 30625 Hannover,Germany.

Apicomplexan parasites are amongst the most prevalent and morbidity-causing pathogens worldwide. They are responsible for severe diseases in humans and livestock and are thus of great public health and economic importance. Until the sequencing of apicomplexan genomes at the beginning of this century, the occurrence of N- and O-glycoproteins in these parasites was much debated. Read More

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http://dx.doi.org/10.1017/S0031182019000040DOI Listing
February 2019

Liver transplant, toxoplasmosis and kidney stones: connecting the dots.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Department of Nephrology, University of Florida College of Medicine, Gainesville, Florida, USA.

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http://dx.doi.org/10.1136/bcr-2019-229197DOI Listing
February 2019

Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite.

Behav Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, 8240 Risskov, Denmark; Department of Clinical Medicine, AUGUST Centre, Aarhus University, Risskov, Denmark.

Toxoplasma gondii (TOX) is an intracellular parasite which infects warm-blooded animals including humans. An increasing number of clinical studies now hypothesize that latent toxoplasmosis may be a risk factor for the development of psychiatric disease. For depression, the results have been varied and we speculate that genetic background is important for the response to latent toxoplasmosis. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.018DOI Listing
February 2019

Toxoplasma gondii infection and toxoplasmosis in North Africa: a review.

Parasite 2019 15;26. Epub 2019 Feb 15.

Laboratoire de Parasitologie, Univ. Manouba, École Nationale de Médecine Vétérinaire de Sidi Thabet, 2020 Sidi Thabet, Tunisia.

Toxoplasmosis is an important zoonosis caused by an obligate intracellular parasitic protozoan, Toxoplasma gondii. The disease is distributed worldwide and can affect all warm-blooded vertebrates, including humans. The present review aimed to collect, compile and summarize the data on the prevalence of T. Read More

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http://dx.doi.org/10.1051/parasite/2019006DOI Listing
February 2019
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Intraocular toxoplasmosis mimicking vitreous lymphoma.

Blood 2019 Feb;133(7):767

University of California at Los Angeles.

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http://dx.doi.org/10.1182/blood-2018-10-883124DOI Listing
February 2019

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018

Socioeconomic vulnerability associated to Toxoplasma gondii exposure in southern Brazil.

PLoS One 2019 14;14(2):e0212375. Epub 2019 Feb 14.

Department of Preventive Veterinary Medicine, Laboratory of Zoonoses and Public Health, Londrina State University, Londrina, Paraná, Brazil.

Human toxoplasmosis, a protozoonosis caused by Toxoplasma gondii, has been described as a worldwide foodborne disease with important public health impact. Despite infection has reportedly varied due to differences in alimentary, cultural and hygienic habits and geographic region, social vulnerability influence on toxoplasmosis distribution remains to be fully established. Accordingly, the present study has aimed to assess T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212375PLOS
February 2019
4 Reads

Potential public health benefits from cat eradications on islands.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007040. Epub 2019 Feb 14.

Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, California, United States of America.

Cats (Felis catus) are reservoirs of several pathogens that affect humans, including Toxoplasma gondii. Infection of pregnant women with T. gondii can cause ocular and neurological lesions in newborns, and congenital toxoplasmosis has been associated with schizophrenia, epilepsy, movement disorders, and Alzheimer's disease. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007040
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http://dx.doi.org/10.1371/journal.pntd.0007040DOI Listing
February 2019
2 Reads

Fresh water snails as intermediate host of trematodes in Iran: A systematic.

Epidemiol Health 2019 Jan 7:e2019001. Epub 2019 Jan 7.

Associate Professor, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari,, Sari, Iran.

Objectives: Freshwater snails, as first intermediate hosts of trematodes, can cause health hazards in animals and humans. Recently, WHO has included Iran among six countries known to have a serious problem with fascioliasis. In addition, Cercarial dermatitis is a job-related disease that is seen often in paddy workers and swimmers of Iran particularly in the Mazandaran province. Read More

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http://dx.doi.org/10.4178/epih.e2019001DOI Listing
January 2019

Toxoplasmic retinochoroiditis: The influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis.

PLoS One 2019 12;14(2):e0211627. Epub 2019 Feb 12.

Laboratory, Oswaldo Cruz Institute -FIOCRUZ, Rio de Janeiro, Brazil.

Purpose: To analyze risk factors for recurrent toxoplasmic retinochoroiditis.

Design: Single center prospective case series.

Population And Methods: A total of 230 patients with toxoplasmic retinochoroiditis were prospectively followed to assess recurrences. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211627PLOS
February 2019

Promising role of Wolbachia as anti-parasitic drug target and eco-friendly biocontrol agent.

Recent Pat Antiinfect Drug Discov 2019 Feb 11. Epub 2019 Feb 11.

Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari. Iran.

Background: Wolbachia is the most common endosymbiotic bacteria in insect-borne parasites and it is the most common reproductive parasite in the world. Wolbachia has been found worldwide in numerous arthropod and parasite species, including: insects, terrestrial isopods, spiders, mites and filarial nematodes. There is a complicated relationship between Wolbachia and its hosts and in some cases, they create a mutual relationship instead of a parasitic relationship. Read More

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http://dx.doi.org/10.2174/1574891X14666190211162403DOI Listing
February 2019

Systematic Identification of Thiosemicarbazides for Inhibition of Growth In Vitro.

Molecules 2019 Feb 10;24(3). Epub 2019 Feb 10.

Department of Immunoparasitology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.

One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to . In the search for such structures, thiosemicarbazide-based compounds have emerged as a novel and promising leads. Here, a series of imidazole-thiosemicarbazides with suitable properties for CNS penetration was evaluated to determine the structural requirements needed for potent anti- activity. Read More

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http://dx.doi.org/10.3390/molecules24030614DOI Listing
February 2019

Cerebral toxoplasmosis after allogeneic hematopoietic stem cell transplantation diagnosed by megagenomic analysis.

Chin Med J (Engl) 2019 Feb 6. Epub 2019 Feb 6.

Department of Hematolgy and Hematological Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

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http://dx.doi.org/10.1097/CM9.0000000000000087DOI Listing
February 2019
1 Read

Prevalence of Toxoplasma and Echinococcus IgG antibodies in slaughterhouse workers, a serosurvey in Northeast Iran

Ann Parasitol 2018 ;64(4):391–397

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Square, 9177948564 Mashhad, Iran

Cystic echinococcosis and toxoplasmosis are two human parasitic diseases. Butchers and slaughterhouse workers are in close contact with body fluids and tissues of ruminants. To investigate the prevalence of Toxoplasma and Echinococcus IgG antibodies in slaughterhouse workers in Northeast of Iran, Mashhad, 2016. Read More

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January 2018
1 Read

Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii.

Microb Pathog 2019 Feb 6;129:112-117. Epub 2019 Feb 6.

UNESP-São Paulo State University, Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, Botucatu, State of São Paulo, Brazil. Electronic address:

Canine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.01.048DOI Listing
February 2019
2 Reads

The Women and Children's Infectious Diseases Center: An integrated approach to congenital infectious diseases.

Clin Invest Med 2019 Jan 30;41(4):E211-E212. Epub 2019 Jan 30.

Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, QC.

Congenital infectious diseases, transmitted during the course of pregnancy, are estimated to affect nearly one in every hundred births worldwide. These infections may be associated with fetal and infant adverse health outcomes, due to congenital malformations caused by in utero transmission of the infectious organism itself (as is the case with cytomegalovirus, toxoplasmosis, syphilis and Zika virus), or due to chronic infection in the infant (as is the case with human immunodeficiency virus [HIV] and hepatitis B and C). In addition, children who are exposed, yet uninfected, may still suffer from the consequences of exposure to infectious pathogens or to the drugs given to treat pregnant women and prevent in utero transmission (as may be the case with HIV infection). Read More

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http://dx.doi.org/10.25011/cim.v41i4.32223DOI Listing
January 2019
1 Read

A Pathway Analysis Based on Genome-Wide DNA Methylation of Chinese Patients with Graves' Orbitopathy.

Biomed Res Int 2019 13;2019:9565794. Epub 2019 Jan 13.

Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: The pathogenesis Graves' Orbitopathy (GO) is not yet fully understood. Here, we conducted a pathway analysis based on genome-wide DNA methylation data of Chinese GO patients to explore GO-related pathways and potential feature genes.

Methods: Six GO patients and 6 age-matched control individuals were recruited, and a genome-scale screen of DNA methylation was measured using their peripheral blood sample. Read More

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http://dx.doi.org/10.1155/2019/9565794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348866PMC
January 2019
1 Read

Outbreak of toxoplasmosis in a flock of domestic chickens (Gallus gallus domesticus) and guinea fowl (Numida meleagris).

Parasitol Res 2019 Feb 6. Epub 2019 Feb 6.

Departamento de Patologia Clínica Veterinária, Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Prédio 42505, Porto Alegre, RS, 91540-000, Brazil.

Toxoplasmosis is a disease with a worldwide distribution that affects a wide variety of animal species, though with rare descriptions in chickens. We describe the clinical, epidemiological, pathological, and molecular aspects of a toxoplasmosis outbreak in domestic chickens and guinea fowl in southern Brazil. The flock was composed of 47 domestic chickens and 29 guinea fowl. Read More

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http://dx.doi.org/10.1007/s00436-019-06233-wDOI Listing
February 2019

Associated Antenatal Health Risk Factors with Incidence of Toxoplasmosis in Egyptian Pregnant Women.

Pak J Biol Sci 2018 Jan;21(9):463-468

Background And Objective: The major maternal toxoplasmosis infection during pregnancy is regularly related to trans-placental transmission to the embryo and newly-borne child. This cross-section study was performed to investigate the prevalence of toxoplasmosis among pregnant women attending antennal health centers.

Materials And Methods: The IgM antibodies against Toxoplasma were quantitatively determined by commercially available kits, while IgG antibodies and avidity (AV) of Toxoplasma gondii-specific IgG antibodies were quantitatively determined by using of conventional ELISA. Read More

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http://dx.doi.org/10.3923/pjbs.2018.463.468DOI Listing
January 2018
1 Read

[Ocular lesions in HIV-infected patients of the ophthalmic hospitals].

Vestn Oftalmol 2018 ;134(6):25-32

Perm State Medical University named after E.A. Wagner, 26 Petropavlovskaya St., Perm, Russian Federation, 614000; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 91 Pervomaiskaya St., Yekaterinburg, Russian Federation, 620041.

Purpose: To analyze ophthalmic pathologies in HIV-infected patients of the ophthalmic hospitals of Perm city.

Material And Methods: Medical records of 75 HIV patients registered in Perm Regional Centre for Prevention and Control of AIDS and Infectious Diseases who had received treatment in ophthalmic in-patient clinics of Perm in 2005-2015 years were analyzed retrospectively. Patient examination included traditional ophthalmological methods, as well as immunological (determination of CD4 cells and viral load), serological (detection of antibodies to herpes simplex virus, cytomegalovirus, chlamydia, toxoplasma), general clinical methods, and consultations by allied specialists. Read More

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http://dx.doi.org/10.17116/oftalma201813406125DOI Listing
January 2018
5 Reads

Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities, and Perspectives.

Trends Parasitol 2019 Feb 1. Epub 2019 Feb 1.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China. Electronic address:

Important progress has been made in understanding how immunity is elicited against Toxoplasma gondii - a complex pathogen with multiple mechanisms of immune evasion. Many vaccine candidates have been tested using various strategies in animal models. However, none of these strategies has delivered as yet, and important challenges remain in the development of vaccines that can eliminate the tissue cysts and/or fully block vertical transmission. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714922193001
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http://dx.doi.org/10.1016/j.pt.2019.01.005DOI Listing
February 2019
5 Reads

Acanthamoeba spp. from water and soil sources in Iran: a systematic review and meta-analysis

Ann Parasitol 2018 ;64(4):285–297

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Farah Abad Road, Sari, Iran

Acanthamoeba, an opportunistic protozoan parasite, is distributed in the environment globally, causes serious human infections, including a fatal encephalitis and keratitis. The purpose of this study was to evaluate the prevalence and genotyping of Acanthamoeba spp. from different water and soil sources in Iran. Read More

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January 2018
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Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis.

Microb Pathog 2019 Jan 29;129:30-42. Epub 2019 Jan 29.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Department of Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Science, Sari, Iran. Electronic address:

Toxoplasmosis, caused by Toxoplasma gondii, is a great public health concern in cancer patients, which can induce serious pathological effects. This systematic review and meta-analysis was performed to evaluate the worldwide seroprevalence rate of T. gondii infection among cancer patients. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.01.040DOI Listing
January 2019

Comprehensive bioinformation analysis of methylated and differentially expressed genes in esophageal squamous cell carcinoma.

Mol Omics 2019 Feb;15(1):88-100

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, North 4th Road, Shihezi 832002, China.

Differentially methylated genes (DMGs) play a crucial role in the etiology and pathogenesis of esophageal squamous cell carcinoma (ESCC). This study aimed to ascertain aberrant DMGs and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE51287 from the Gene Expression Omnibus (GEO). Read More

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http://dx.doi.org/10.1039/c8mo00218eDOI Listing
February 2019
1 Read

Pets in modern society: hidden threats.

Ter Arkh 2018 Nov;90(11):105-111

Central Research Institute of Epidemiology, Federal Supervision Service for Consumer Rights Protection and People's Welfare, Moscow, Russia.

The article discusses the problem of the role of pets as a source of zoonotic infections, representing a hidden threat to modern society. Since the content is now very popular at home, both traditional and exotic animals, it is necessary to develop an interdisciplinary program to control the spread of zoonotic infections and the risks of their infection with people. Since the problem lies in the intersection of several disciplines, joint efforts of doctors, veterinarians, health organizers and laboratory specialists are necessary. Read More

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http://dx.doi.org/10.26442/terarkh20189011105-111DOI Listing
November 2018
1 Read

Opportunistic diseases in patients with HIV infection in the intensive care unit.

Ter Arkh 2018 Nov;90(11):13-17

Peoples Friendship University of Russia (RUDN University), Moscow, Russia.

Aim: The aim of the study was to analyze the incidence and prevalence of opportunistic diseases and comorbidities in patients admitted in the intensive care unit.

Materials And Methods: A specialized intensive care unit (ICU) for patients with severe HIV infection was set up in 2014 at the infectious diseases 2nd state hospital Moscow. It provides intensive care and treatments for HIV patients with severe co-morbidities and opportunistic infections. Read More

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http://dx.doi.org/10.26442/terarkh2018901113-17DOI Listing
November 2018
5 Reads

Plasmonic gold chips for the diagnosis of Toxoplasma gondii, CMV, and rubella infections using saliva with serum detection precision.

Eur J Clin Microbiol Infect Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Chemistry, Stanford University, William Keck Science Building rm 125, Stanford, CA, 94305-5080, USA.

Sampling the blood compartment by an invasive procedure such as phlebotomy is the most common approach used for diagnostic purposes. However, phlebotomy has several drawbacks including pain, vasovagal reactions, and anxiety. Therefore, alternative approaches should be tested to minimize patient's discomfort. Read More

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http://dx.doi.org/10.1007/s10096-019-03487-1DOI Listing
January 2019
1 Read

Transdisciplinary and social-ecological health frameworks-Novel approaches to emerging parasitic and vector-borne diseases.

Parasite Epidemiol Control 2019 Feb 11;4:e00084. Epub 2019 Jan 11.

Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.

Ecosystem Health, Conservation Medicine, EcoHealth, One Health, Planetary Health and GeoHealth are inter-related disciplines that underpin a shared understanding of the functional prerequisites of health, sustainable vitality and wellbeing. All of these are based on recognition that health interconnects species across the planet, and they offer ways to more effectively tackle complex real-world challenges. Herein we present a bibliometric analysis to document usage of a subset of such terms by journals over time. Read More

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http://dx.doi.org/10.1016/j.parepi.2019.e00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348238PMC
February 2019
1 Read

Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis.

BMC Genomics 2019 Jan 30;20(1):97. Epub 2019 Jan 30.

College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, People's Republic of China.

Background: Toxoplasma gondii is an obligate intracellular parasite that infects humans and other warm-blooded animals. Previous quantitative proteomic analyses of infected host cells revealed that the expression of many host proteins is modulated by T. gondii infection. Read More

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http://dx.doi.org/10.1186/s12864-019-5458-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354428PMC
January 2019

Erratum: Prevalence and risk factors of toxoplasmosis among adults in a small Brazilian city.

Authors:

Rev Soc Bras Med Trop 2019 01 24;52:e20190099. Epub 2019 Jan 24.

[This corrects the article doi: 10.1590/0037-8682-0214-2017]. Read More

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http://dx.doi.org/10.1590/0037-8682-0099-2019DOI Listing
January 2019

The Correlation between Serum Levels of Anti- Antibodies and the Risk of Diabetes.

Iran J Parasitol 2018 Oct-Dec;13(4):637-642

Dept. of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: This study investigated the presence of specific antibodies against infection among people with diabetes (type I and II) in comparison with control group.

Methods: Overall 300 serum samples were collected equally from three groups including patients with type I and type II diabetes and non-diabetic healthy control that referred to Tabriz Central Laboratory in northwest Iran during July to Sep 2015. The level of specific IgG and IgM antibodies against were measured using the chemiluminescence immunoassay (CLIA) method. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348218PMC
January 2019
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Detection of Toxoplasma gondii in Crassostrea spp. oysters cultured in an estuarine region in eastern Amazon.

Zoonoses Public Health 2019 Jan 27. Epub 2019 Jan 27.

Laboratory of Zoonoses and Public Health (LZSP), Graduate Program in Animal Health in the Amazon, Institute of Veterinary Medicine, Federal University of Pará (UFPA), Castanhal, Pará, Brazil.

The aim of the present study was to detect DNA of Toxoplasma gondii in Crassostrea spp. oysters cultured in the state of Pará, Brazil. A total of 400 oysters were directly collected from a fixed rack system. Read More

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http://dx.doi.org/10.1111/zph.12564DOI Listing
January 2019

Aetiology of livestock fetal mortality in Mazandaran province, Iran.

PeerJ 2019 18;6:e5920. Epub 2019 Jan 18.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

In the farming industry, the productivity of livestock herds depends on the fertility efficiency of animals. The accurate diagnosis of a broad range of aetiological agents causing fetal death is often difficult. Our aim was to assess the prevalence rates of , , and spp. Read More

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http://dx.doi.org/10.7717/peerj.5920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340351PMC
January 2019
1 Read

Simultaneous circulation of arboviruses and other congenital infections in pregnant women in Rio de Janeiro, Brazil.

Acta Trop 2019 Jan 24;192:49-54. Epub 2019 Jan 24.

Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, Brazil; Departamento de Patologia, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, Brazil. Electronic address:

Background: Arboviruses (Zika, dengue and chikungunya) represent a major risk for pregnant women, especially because their vertical transmission can lead to neurological damage in newborns. Early diagnosis can be difficult due to similar clinical presentation with other congenital infections that are associated with congenital abnormalities.

Objectives: To investigate the circulation of arboviruses and other pathogens responsible for congenital infections, reporting clinical aspects and geographic distribution of maternal rash in a metropolitan region of Rio de Janeiro (Brazil). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.020DOI Listing
January 2019
3 Reads

Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin.

BMC Infect Dis 2019 Jan 25;19(1):91. Epub 2019 Jan 25.

GEPAMOL, Centro de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia.

Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools.

Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Read More

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http://dx.doi.org/10.1186/s12879-018-3613-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347798PMC
January 2019
3 Reads

[Retrospective evaluation of serologic and molecular test results of toxoplasmosis suspected patients].

Mikrobiyol Bul 2019 Jan;53(1):96-105

Erciyes University Faculty of Medicine, Department of Parasitology, Kayseri, Turkey.

Toxoplasma gondii is a compulsory intracellular protozoan parasite with a wide range of host in warm-blooded vertebrates and has importance in terms of health and economy. Toxoplasmosis is very common because it can infect people with a variety of ways; ingestion of contaminated water and nutrients; raw or undercooked meats containing tissue cysts, blood transfusions, organ transplantantation and transplacental transfer. The aim of this study was to evaluate serologic and molecular test results of toxoplasmosis pre-diagnosed patients. Read More

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http://dx.doi.org/DoiYapistirDOI Listing
January 2019
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[Silencing the target rhoptry neck protein (RON) gene responsible for the invasion of Toxoplasma gondii with siRNA transfection].

Mikrobiyol Bul 2019 Jan;53(1):81-95

Erciyes University Faculty of Medicine, Kayseri, Turkey.

Toxoplasma gondii is a coccidian protozoan that causes toxoplasmosis is a common disease in Turkey as well as all over the world. It causes various clinical symptoms depending on the immune system status, age, or location of the disease. There is an organelle called the apical complex at the anterior end of the parasite. Read More

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http://dx.doi.org/10.5578/mb.67701DOI Listing
January 2019
5 Reads

Anti-parasitic effect on Toxoplasma gondii induced by a spider peptide lycosin-I.

Exp Parasitol 2019 Jan 22;198:17-25. Epub 2019 Jan 22.

Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, PR China. Electronic address:

Toxoplasmosis is a widely distributed parasitic protozoan disease, caused by Toxoplasma gondii (T. gondii). High prevalence of toxoplasmosis and limitations of conventional treatments lead to a search for new therapeutic drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144894183008
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http://dx.doi.org/10.1016/j.exppara.2019.01.009DOI Listing
January 2019
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A systematic review on efficiency of microneme proteins to induce protective immunity against Toxoplasma gondii.

Eur J Clin Microbiol Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Toxoplasma gondii is an intracellular parasite infecting almost all warm-blooded animals. Many studies on vaccination have been performed previously, and micronemal proteins (MICs) have crucial importance in this regard. The current review aims to reveal the efficiency of MICs as target antigen, adjuvants, animal models (species/strain), T. Read More

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http://link.springer.com/10.1007/s10096-018-03442-6
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http://dx.doi.org/10.1007/s10096-018-03442-6DOI Listing
January 2019
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Vaccination with recombinant adenoviruses expressing Toxoplasma gondii MIC3, ROP9, and SAG2 provide protective immunity against acute toxoplasmosis in mice.

Vaccine 2019 Feb 19;37(8):1118-1125. Epub 2019 Jan 19.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China; Key Laboratory of Zoonosis, Shenyang Agricultural University, Shenyang, Liaoning 110866, China. Electronic address:

Toxoplasmosis is a worldwide zoonosis caused by the protozoan parasite Toxoplasma gondii, an obligate intracellular parasite. Currently, no viable vaccine or effective drug strategies exist to prevent and control toxoplasmosis. T. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183172
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http://dx.doi.org/10.1016/j.vaccine.2018.12.044DOI Listing
February 2019
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Seroprevalence of and infections and associated factors in sheep from Costa Rica.

Parasite Epidemiol Control 2019 Feb 10;4:e00085. Epub 2019 Jan 10.

Programa de Investigación en Medicina Poblacional, Escuela de Medicina Veterinaria, Universidad Nacional (UNA), P.O. Box 86-3000, Heredia, Costa Rica.

The presence of antibodies against and were analyzed in 392 sheep sera from ten Costa Rican ovine flocks using indirect immuno-enzymatic assays. Additionally, general information about sheep management, environment, and clinical reproductive disorders was assessed through a questionnaire to inquire factors related to these apicomplexan parasites. A total of 161 (41. Read More

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http://dx.doi.org/10.1016/j.parepi.2019.e00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330264PMC
February 2019
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Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants.

J Biomed Sci 2019 Jan 21;26(1):10. Epub 2019 Jan 21.

Laboratório de Imunofisiologia da Reprodução, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará, 1720, Building: 2B, CEP, Uberlândia, 38405-320, Brazil.

Background: Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlândia city, Brazil, two virulent strains were isolated: TgChBrUD1 and TgChBrUD2. Read More

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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929
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http://dx.doi.org/10.1186/s12929-019-0503-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340180PMC
January 2019
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ROP9, MIC3, and SAG2 are heparin-binding proteins in Toxoplasma gondii and involved in host cell attachment and invasion.

Acta Trop 2019 Jan 18;192:22-29. Epub 2019 Jan 18.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, Changchun, China; Key Laboratory of Zoonosis, Shenyang Agricultural University, Shenyang, China. Electronic address:

Toxoplasma gondii (T. gondii) is an obligatory intracellular parasite that can infect varieties of warm-blooded animals, including humans and birds. Heparan sulfate (HS) is widely distributed on the eukaryotic cell surface of vertebrates and can inhibit T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.001DOI Listing
January 2019
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ACUTE MYOCARDITIS WITH CARDIOGENIC SHOCK AND MULTIPLE ORGAN FAILURE, FOLLOWED BY BILATERAL PANUVEITIS MASQUERADING AS ENDOGENOUS ENDOPHTHALMITIS, DUE TO TOXOPLASMA GONDII IN AN IMMUNOCOMPETENT PATIENT.

Retin Cases Brief Rep 2019 Jan 17. Epub 2019 Jan 17.

Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, Massachusetts.

Purpose: To report a case of systemic and ocular toxoplasmosis in an immunocompetent patient, who developed myocarditis with resulting cardiogenic shock and multiple organ failure, followed by bilateral panuveitis masquerading as endogenous endophthalmitis.

Methods: Single case report with images.

Results: A 59-year-old man with a history of monoclonal gammopathy of undetermined significance and associated scleromyxedema but otherwise immunocompetent was admitted to the intensive care unit for cardiogenic shock and multiple organ failure due to presumed viral myocarditis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000855DOI Listing
January 2019
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First report of caprine abortions due to Chlamydia abortus in Argentina.

Vet Med Sci 2019 Jan 21. Epub 2019 Jan 21.

Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, CEDIVE, La Plata, Argentina.

Infectious abortions of goats in Argentina are mainly associated with brucellosis and toxoplasmosis. In this paper, we describe an abortion outbreak in goats caused by Chlamydia abortus. Seventy out of 400 goats aborted. Read More

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http://dx.doi.org/10.1002/vms3.145DOI Listing
January 2019
2 Reads