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BMC Neurol 2022 Jun 24;22(1):233. Epub 2022 Jun 24.

Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.

Background: The present case contributes to the limited literature on central nervous system involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN).  CASE PRESENTATION : A 63-year-old male presented to the department of neurology with a three-day history of rapidly progressing headache, fatigue, and confusion. Physical examination revealed multiple bruise-like skin lesions. Read More

Infect Disord Drug Targets 2022 Jun 22. Epub 2022 Jun 22.

Imam Hossein Hospital, Shahid Beheshti University of Medical Science. Tehran, Iran.

Background: In immunocompromised organ transplant recipients, toxoplasmosis can be caused by either an infected graft or a latent infection, during which transformation from a chronic state to an active infection (reactivation) is observed. PCR is an accurate and sensitive molecular method widely used in medical sciences, especially in diagnostic procedures.

Objective: The aim of this study was to determine the prevalence of early toxoplasmosis infection in bone marrow transplant patients by PCR. Read More

Pathogens 2022 Jun 10;11(6). Epub 2022 Jun 10.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, (Chinese Center for Tropical Diseases Research), Shanghai 200025, China.

is an intracellular obligate parasite that causes toxoplasmosis, a zoonotic infection that affects warm-blooded animals and humans worldwide. To comprehensively characterize the disease condition in Pakistan for future reference, we ascertained the prevalence of infection and predisposing factors in the Pakistani population over a 20-year period. We systematically reviewed research articles published in English (2000-2020) from PubMed and Google Scholar. Read More

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Parasitology-Mycology, University Hospital and Grenoble-Alpes University, 38043 Grenoble, France.

The high sensitivity of the automated tests used for serology can yield false-positive IgM results due to aspecific reactions. On the other hand, specific therapy can delay IgG production and, therefore, the diagnosis of seroconversion. There is a need for confirmation tests to early detect seroconversions during pregnancy. Read More

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.

The utilization of fluorescein-guided biopsies has recently been discussed to improve and expedite operative techniques in the detection of tumor-positive tissue, as well as to avoid making sampling errors. In this study, we aimed to report our experience with fluorescein-guided biopsies and elucidate distribution patterns in different histopathological diagnoses in order to develop strategies to increase the efficiency and accuracy of this technique. We report on 45 fluorescence-guided stereotactic biopsies in 44 patients (15 female, 29 male) at our institution from March 2016 to March 2021, including 25 frame-based stereotactic biopsies and 20 frameless image-guided biopsies using VarioGuide. Read More

Int J Environ Res Public Health 2022 Jun 19;19(12). Epub 2022 Jun 19.

Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.

Background: () is a ubiquitous obligatory intracellular parasite which infects over 40 million Americans and causes toxoplasmosis. Inside the human body, can damage tissues and invade vital organs.

Methods: This study evaluated the association of infection and liver disease using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2010, with a sample size of 3371 participants (age 20-80 years). Read More

Biomedicines 2022 Jun 6;10(6). Epub 2022 Jun 6.

National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Toxoplasmosis is a serious zoonotic disease that threatens human and animal health. Here, we evaluated the vaccine potential of the deletion of rhoptry protein 38 (PruΔ) through its pathogenicity and immunoprotective efficacy in mice. Mice inoculated intraperitoneally with 1 × 10, 2 × 10, or 4 × 10 PruΔ showed no visible signs, whereas mice inoculated with 1 × 10 parental Pru strain showed obvious wasting and bow-back, suggesting a significantly lower pathogenicity of PruΔ in mice. Read More

PLoS One 2022 23;17(6):e0270377. Epub 2022 Jun 23.

Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Introduction: Neurotropic pathogens such as Toxoplasma gondii (T. gondii) which result in chronic infections in the brain are associated with mental illnesses. In view of this, a growing body of literature has revealed the possible interaction of schizophrenia and T. Read More

Ann Med Surg (Lond) 2022 Jun 17;78:103802. Epub 2022 May 17.

Department of Ophthalmology. Farhat Hached University Hospital, Sousse, Tunisia.

-Kyrieleis arteritis is a rare manifestation in posterior uveitis-Kyrieleis arteritis is most frequently reported in ocular toxoplasmosis.-The pathogenesis still highly debated.-It is characterized by the presence of focal, segmental plaques or exudates within retinal arteries. Read More

Ann Med Surg (Lond) 2022 Jun 20;78:103842. Epub 2022 May 20.

Department of Infectious Diseases, Hamad Medical Corporation, P.O 3050, Doha, Qatar.

Background And Introduction: Human immune deficiency virus (HIV) infection remains a major health problem since discovery of the virus in 1981. Globally, since introduction of antiretroviral therapy, AIDS-related mortality was reduced by 47% since 2010. Also, HIV-related opportunistic infections (OIs) became less common, especially with use of prophylaxis to prevent such infections. Read More

Front Immunol 2022 6;13:910961. Epub 2022 Jun 6.

Pathology, Microbiology and Immunology department, School of Veterinary Medicine, University of California Davis, Davis, CA, United States.

Toxoplasmosis is a worldwide disease affecting all warm-blooded animals, including humans. Vaccination strategies aimed at inducing an efficient immune response while preventing transmission have been attempted in the past. While many different approaches can partially protect immunized animals against subsequent infections, full and lasting protection is rarely attained and only with live-attenuated vaccines. Read More

BMJ Case Rep 2022 06 21;15(6). Epub 2022 Jun 21.

Vitreo-retina, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneshwar, Odisha, India

N Z Med J 2022 Apr 14;135(1553):10-18. Epub 2022 Apr 14.

PhD MBChB FRANZCO - Consultant Ophthalmologist; Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand.

Aim: Our aim was to examine rate of recurrence of toxoplasmosis retinochoroiditis and risk factors for recurrence. No New Zealand epidemiological data on recurrence rates of toxoplasmosis retinochoroiditis have been previously published.

Methods: Retrospective chart review of all patients with toxoplasmosis retinochoroiditis presented to Auckland District Health Board Department of Ophthalmology between 2006-2019. Read More

PLoS Pathog 2022 Jun 21;18(6):e1010296. Epub 2022 Jun 21.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Initial TCR engagement (priming) of naive CD8+ T cells results in T cell expansion, and these early events influence the generation of diverse effector and memory populations. During infection, activated T cells can re-encounter cognate antigen, but how these events influence local effector responses or formation of memory populations is unclear. To address this issue, OT-I T cells which express the Nur77-GFP reporter of TCR activation were paired with the parasite Toxoplasma gondii that expresses OVA to assess how secondary encounter with antigen influences CD8+ T cell responses. Read More

Interdiscip Perspect Infect Dis 2022 16;2022:8034295. Epub 2022 Jun 16.

Toxoplasmosis Research Center, Communicable Diseases Institute, Iranian National Registry Center for Lophomoniasis (INRCL), Mazandaran University of Medical Sciences, Sari, Iran.

Background: is an emerging protozoan agent that mainly infects the lower respiratory system, causing pulmonary lophomoniasis. The bronchoscopic findings in patients with pulmonary lophomoniasis have not been investigated yet. Accordingly, we assess the bronchoscopic findings of lophomoniasis in patients suffering from pulmonary lophomoniasis through a registry-based clinical study. Read More

Diagn Microbiol Infect Dis 2022 May 13;103(4):115724. Epub 2022 May 13.

Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil. Electronic address:

The aim of the study was to describe the heterogeneity of the humoral immune response and pregnancy outcomes in infected women during an outbreak of toxoplasmosis. Forty-two pregnant women referred to the University Hospital of Santa Maria (HUSM), RS, Brazil in 2018 and 2019, were evaluated. Clinical symptoms were reported in 33. Read More

Can J Ophthalmol 2022 Jun 15. Epub 2022 Jun 15.

Department of Ophthalmology, Hospital Saint-Sacrement, University of Quebec Centre Hospital-Laval University Research Centre, Quebec, Que. Electronic address:

Purpose: To review the clinical usefulness of chorioretinal biopsies in diagnostically undefined cases of intraocular inflammation or chorioretinal lesions.

Design: Retrospective case series.

Participants: Seven patients who underwent chorioretinal biopsies. Read More

ACS Chem Biol 2022 Jun 17. Epub 2022 Jun 17.

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand.

Pyrimethamine (Pyr), a known dihydrofolate reductase (DHFR) inhibitor, has long been used to treat toxoplasmosis caused by (Tg) infection. However, Pyr is effective only at high doses with associated toxicity to patients, calling for safer alternative treatments. In this study, we investigated a series of Pyr analogues, previously developed as DHFR inhibitors of bifunctional DHFR-thymidylate synthase (PfDHFR-TS), for their activity against DHFR-TS (TgDHFR-TS). Read More

Parasitol Res 2022 Jun 17. Epub 2022 Jun 17.

Department of Medical Parasitology, Faculty of Medicine, Mansoura University, 2 El Gomhouria Street, Mansoura, 35516, Egypt.

Toxoplasma gondii is a worldwide prevalent parasite. The infection has been linked to variable inflammatory effects including neuroinflammation. Biochanin A (BCA) is an isoflavone, known for its anti-inflammatory and anti-oxidative properties. Read More

Mol Immunol 2022 Jun 13;149:27-38. Epub 2022 Jun 13.

Departamento de Parasitologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Parasitic protozoa are eukaryotic unicellular organisms that depend on a variety of living organisms and can develop intra- and extracellularly inside their hosts. In humans, these parasites cause diseases with a significant impact on public health, such as malaria, toxoplasmosis, Chagas disease, leishmaniasis and amebiasis. The ability of a parasite in establishing a successful infection depends on a series of intricate evolutionarily selected adaptations, which include the development of molecular and cellular strategies to evade the host immune system effector mechanisms. Read More

Front Microbiol 2022 30;13:902855. Epub 2022 May 30.

Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.

The global distribution of breast cancer and the opportunistic nature of the parasite have resulted in many patients with breast cancer becoming infected with toxoplasmosis. However, very limited information is available about the potential effects of tamoxifen on chronic toxoplasmosis and its contribution to the reactivation of the latent infection. The present study investigated the potential effects of tamoxifen on chronic toxoplasmosis in animal models (Swiss albino mice). Read More

Case Rep Oncol 2022 Jan-Apr;15(1):430-435. Epub 2022 Apr 21.

Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada-city, Japan.

A 30-year-old woman was pointed out for her right axillary lymphadenopathy in a medical checkup. Ultrasonography showed two swollen lymph nodes and the presence of lymph node hilum with a convex shape in the larger lymph node. Under the tentative diagnosis of lymphadenitis, the patient was initially treated with antibiotic therapy, leading to no improvement in her lymphadenopathy for 1 month. Read More

Pathog Glob Health 2022 Jun 11:1-10. Epub 2022 Jun 11.

Parasitology Division, Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

infection in the central nervous system commonly occurs among immunodeficient patients. Its prevalence is high in countries with a high burden of HIV and low coverage of antiretroviral drugs. The brain is one of the predilections for infection due to its low inflammatory reaction, and cerebral toxoplasmosis occurs solely due to the reactivation of a latent infection rather than a new infection. Read More

Cureus 2022 May 8;14(5):e24827. Epub 2022 May 8.

Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IND.

Central nervous system (CNS) toxoplasmosis is one of the common causes of hemorrhagic brain lesions in people living with HIV and AIDS (PLWHA), resulting in high mortality and morbidity. It has a broad clinical and neuro-radiological spectrum, which may or may not be limited to typical findings of focal and subacute neurological deficits or ring-enhancing lesions in the basal ganglia. Here, we present a case of a patient who is a newly detected person living with HIV and AIDS with a low CD cell count and classical imaging findings of central nervous system toxoplasmosis on his magnetic resonance imaging (MRI) of the brain. Read More

Clin Med Insights Case Rep 2022 7;15:11795476221103813. Epub 2022 Jun 7.

Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Mazandaran University of Medical Sciences, Sari, Iran.

Opium addiction can cause symptoms in the central or peripheral neurological systems, as well as gastrointestinal disorders and anemia; in such situations, lead poisoning should be considered and chelation therapy should be started as soon as possible. In adults, lead poisoning is an unusual cause of abdominal pain. A common form of lead neuropathy includes weakness of the wrist and finger extensors. Read More

J Parasit Dis 2022 Jun 14;46(2):337-342. Epub 2021 Sep 14.

Department of Microbiology & Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.

Toxoplasmosis is a globally parasitic zoonotic disease transmitted by protozoa. This infection in its chronic form can cause a change in its host's specific behavior and is also associated with developing neuropsychological symptoms in humans. Changes in neurotransmitters' levels, especially dopamine, have been identified as a behavior change factor in the infected host. Read More

Transpl Infect Dis 2022 Jun 11:e13880. Epub 2022 Jun 11.

Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, NSW, Australia.

Animals (Basel) 2022 May 28;12(11). Epub 2022 May 28.

State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China.

and belong to the Apicomplexan protozoa which is an obligate intracellular parasite, causing toxoplasmosis and neosporosis throughout the world. Cats and dogs are the definitive hosts of these two parasites. However, information on the epidemiology of toxoplasmosis and neosporosis in stray cats and dogs in the Qinghai-Tibetan Plateau Area (QTPA) is limited, and little is known about the diversity of the diseases. Read More

PLoS One 2022 9;17(6):e0266214. Epub 2022 Jun 9.

Clínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Durango, Mexico.

We determined the association between Toxoplasma gondii (T. gondii) infection and insomnia. Through an age-and gender-matched case-control study, 577 people with insomnia (cases) and 577 people without insomnia (controls) were tested for anti-T. Read More