24,450 results match your criteria Toxoplasmosis


Association between ocular toxoplasmosis and APEX1 and MYD88 polymorphism.

Acta Trop 2021 Jun 9:106006. Epub 2021 Jun 9.

Laboratory of Biology of Malaria and Toxoplasmosis, Department of Parasitology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address:

Ocular toxoplasmosis (OT) is the most common form of posterior uveitis, and in some countries, it is the most frequent cause of visual impairment. Studies demonstrate that the polymorphism in genes involved with the immune response can be related both to the occurrence and to the recurrence of OT. Thus, the present study aimed to analyze the association between OT and the polymorphism of the APEX1 (rs1130409) and MyD88 (rs7744) genes. Read More

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Distinguishing swept-source optical coherence tomography findings in active toxoplasmic retinochoroiditis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Objective: To define the swept-source optical coherence tomography (SS-OCT) features which distinguish ocular toxoplasmosis (OT) from other forms of retinochoroiditis.

Methods: This is a prospective diagnostic study enrolling 43 eyes of 43 patients with active toxoplasmic (TOXO) retinochoroiditis matched to 54 eyes (54 lesions) with non-TOXO retinochoroiditis evaluated by structural SS-OCT.

Results: The finding of retinal hyper-reflective round deposits, sub-lesional choroidal thickening, and sub-lesional retinal pigment epithelium elevation were more likely to be found in TOXO lesions with a positive likelihood ratio of 45. Read More

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Epidemic preparedness: Prenatal Zika virus screening during the next epidemic.

BMJ Glob Health 2021 Jun;6(6)

Health Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK

Zika virus (ZIKV) is a vectorborne infectious agent of global public health significance due to its potential to cause severe teratogenic outcomes. The question of whether health systems should consider adopting screening programmes for ZIKV infections during pregnancy warrants consideration. In this analysis, we apply the Wilson-Jungner framework to appraise the potential utility of a prenatal ZIKV screening programme, outline potential screening strategies within the case-finding pathway, and consider other epidemiological factors that may influence the planning of such a screening programme. Read More

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Morphological and Molecular Identification of Emerged Lophomonas blattarum Infection in Mazandaran Province, Northern Iran: First Registry-Based Study.

Acta Parasitol 2021 Jun 11. Epub 2021 Jun 11.

Toxoplasmosis Research Center, Communicable Diseases Institute, Iranian National Registry Center for Lophomoniasis (INRCL), Mazandaran University of Medical Sciences, Farah-Abad Road, P.O Box: 48471- 91971, Sari, Iran.

Background: In the last decade, several cases of bronchopulmonary lophomoniasis (BPL) have been recorded. Little information is available about epidemiological aspects on Lophomonas infection among BPL patients. The present study was aimed to investigate the prevalence of Lophomonas spp. Read More

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The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii.

Biochem J 2021 Jun 11. Epub 2021 Jun 11.

Universita degli Studi di Verona, Verona, Italy.

Centrins are conserved calcium (Ca2+)-binding proteins typically associated with centrosomes that have been implicated in several biological processes. In Toxoplasma gondii, a parasite that causes toxoplasmosis, three centrin isoforms have been recognized. We have recently characterized the metal binding and structural features of isoform 1 (TgCEN1), demonstrating that it possesses properties consistent with a role as a Ca2+ sensor and displays a Ca2+-dependent tendency to self-assemble. Read More

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Molecular diagnosis of toxoplasmosis: recent advances and a look to the future.

Expert Rev Anti Infect Ther 2021 Jun 11. Epub 2021 Jun 11.

Service de Parasitologie-Mycologie, CHU Grenoble Alpes, Grenoble, 38000, France.

Introduction: Toxoplasmosis is a globally distributed parasitic infection that can be particularly severe when opportunistic or congenital. Its diagnosis requires accurate and rapid techniques that rely mainly on serology and molecular methods.

Areas Covered: The aim of this review was to discuss the positioning of the molecular diagnosis of toxoplasmosis according to the different clinical situations possibly resulting from infection with , and to detail recent developments in this technique. Read More

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Detection of Toxoplasma gondii in water for human consumption from water wells (jagüeyes) in the rural area of the municipality of Sincelejo

Biomedica 2021 05 31;41(Supl. 1):82-99. Epub 2021 May 31.

Investigaciones Biomédicas, Universidad de Sucre, Sincelejo, Colombia.

Introduction: Toxoplasmosis is an orally-transmitted zoonosis that may appear after consuming food contaminated with any infective form of Toxoplasma gondii. Its transmission by water has been reported in several countries including Colombia. The rural population of Sincelejo could be at risk of contracting toxoplasmosis through this route given that they lack potable water. Read More

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A woman in her forties with unilateral blurred vision and pain upon eye movement.

Tidsskr Nor Laegeforen 2021 06 3;141(9). Epub 2021 Jun 3.

Background: Toxoplasmosis is a relatively common cause of infectious papillitis and neuroretinitis, which may affect both immunocompetent and immunodeficient patients.

Case Presentation: A previously healthy woman in her mid-forties presented with subacute onset of unilateral blurred vision and retrobulbar pain exacerbated by eye movements. Ophthalmological assessment revealed decimal best-corrected visual acuity of 0. Read More

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Calcium signaling through a Transient Receptor Channel is important for growth.

Elife 2021 Jun 9;10. Epub 2021 Jun 9.

Cellular Biology, University of Georgia, Athens, United States.

Transient Receptor Potential (TRP) channels participate in calcium ion (Ca) influx and intracellular Ca release. TRP channels have not been studied in or any other apicomplexan parasite. In this work we characterize TgGT1_310560, a protein predicted to possess a TRP domain (TgTRPPL-2) and determined its role in Ca signaling in , the causative agent of toxoplasmosis. Read More

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A 64-year-old woman with rapid neurologic decline diagnosed with encephalitis after presumed metastatic cancer.

SAGE Open Med Case Rep 2021 24;9:2050313X211019784. Epub 2021 May 24.

University of California, Irvine School of Medicine, Irvine, CA, USA.

In an era of fragmented medical care, concurrent clinical features that ultimately lead to a unified diagnosis may not be prioritized appropriately. We present a case of a 64-year-old woman referred to hematology clinic for anemia, with recent memory loss and gait disturbance. Two months later, she developed pneumonia; imaging workup showed a left renal mass. Read More

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In vitro evaluation of new 4-thiazolidinones on invasion and growth of Toxoplasma gondii.

Int J Parasitol Drugs Drug Resist 2021 Jun 2;16:129-139. Epub 2021 Jun 2.

Grupo GICOC, Universidad del Quindío, Armenia. Electronic address:

Treatments for toxoplasmosis such as pyrimethamine have shown numerous side effects. It has been reported that the likelihood of relapse associated with pyrimethamine-based therapy in patients with HIV and toxoplasmic encephalitis (TE) can have significant implications, even for patients who often develop new lesions in areas of the brain previously free of infection. This led us to research for new agents against Toxoplasma gondii. Read More

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GRA8 DNA vaccine formulations protect against chronic toxoplasmosis.

Microb Pathog 2021 Jun 7;158:105016. Epub 2021 Jun 7.

Ege University Faculty of Medicine, Department of Parasitology, Bornova, İzmir, Turkey; Ege University, Vaccine Development, Application and Research Center, Bornova, İzmir, Turkey. Electronic address:

Toxoplasma gondii has a very wide host range and infects all warm-blooded animals including humans. The disease causes great economic losses both in animals and humans. Vaccination is the most effective approach to fight against toxoplasmosis however an effective vaccine has not been developed yet. Read More

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Congenital ocular toxoplasmosis with torpedo maculopathy and retinopathy of prematurity in a premature baby.

Am J Ophthalmol Case Rep 2021 Sep 13;23:101121. Epub 2021 May 13.

Moorfields Eye Hospitals UAE, Dubai, United Arab Emirates.

Purpose: To report an unusual case of congenital bilateral abnormality due to coexisting ocular toxoplasmosis and retinopathy of prematurity.

Observations: A prematurely born baby with bilateral retinopathy of prematurity (ROP) (one eye treated) was found to have a hyperpigmented torpedo maculopathy lesion in one eye while the other eye presented with microphthalmia, congenital cataract and non-specific pigmentary retinopathy. Following negative TORCH screening, laboratory tests subsequently revealed increased plasma IgG and IgM for toxoplasmosis. Read More

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September 2021

Human Papillomavirus Infection at the Time of Delivery.

Cureus 2021 Jun 1;13(6):e15364. Epub 2021 Jun 1.

Biophysics Laboratory, Stefan S Nicolau Institute of Virology, Bucharest, ROU.

Human papillomavirus (HPV) is one of the most encountered viral etiologies of genital infections that are transmitted through the sexual route in sexually active females. In the genital area, condylomata acuminate warts and the Buschke-Loewenstein tumor (giant condyloma acuminatum) are described. These lesions are associated with benign HPV6 and HPV 11 types. Read More

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Recent aspects on epidemiology, clinical disease, and genetic diversity of Toxoplasma gondii infections in Australasian marsupials.

Parasit Vectors 2021 Jun 5;14(1):301. Epub 2021 Jun 5.

Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20895, USA.

Background: Toxoplasma gondii infections are common in humans and animals worldwide. Among all intermediate hosts of T. gondii, captive marsupials from Australia and New Zealand are highly susceptible to clinical toxoplasmosis. Read More

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CLINICAL FEATURES OF THE HIV INFECTION COURSE AND THE DEPENDENCE OF CHANGES IN LABORATORY PARAMETERS ON THE CLINICAL STAGE AND ON THE CD4 LYMPHOCYTES LEVEL.

Wiad Lek 2021 ;74(5):1189-1195

SUMY STATE UNIVERSITY, SUMY, UKRAINE.

Objective: The aim: Is to determine the features of the HIV infection and changes in indicators of endogenous intoxication and immunoreactivity depending on the clinical stage and the level of CD4 lymphocytes.

Patients And Methods: Materials and methods: 72 HIV-patients were examined. Comparison group included 40 healthy blood donors. Read More

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The prevalence of Toxoplasma gondii in sheep in China: A systematic review and meta-analysis.

Res Vet Sci 2021 May 25;138:19-29. Epub 2021 May 25.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China. Electronic address:

Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, which is widespread in warm-blooded animals and humans. Currently, many studies regarding T. gondii infection in sheep have been published worldwide. Read More

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The Delayed Death-Causing Nature of Rosmarinus officinalis Leaf Extracts and Their Mixture within Experimental Chronic Toxoplasmosis: Therapeutic and Prophylactic Implications.

Acta Trop 2021 Jun 2:105992. Epub 2021 Jun 2.

Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt.

Background: The restricted effect, significant toxicity, and emerging resistance of anti-toxoplasmosis synthetic agents impose the search for alternatives. The current research aimed to evaluate the prophylactic and therapeutic efficacy of Rosmarinus officinalis extracts and their mixtures against chronic murine toxoplasmosis and to clarify the phenomenon of delayed death.

Methods: This research included two experimental designs, the first to test the preventive and curative efficacy of the extracts and the second to assess delayed death in mice infected with the ME49 strain of Toxoplasma gondii. Read More

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Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Infection.

Immunohorizons 2021 Jun 4;5(6):384-394. Epub 2021 Jun 4.

Department of Pathobiology, University of Pennsylvania, Philadelphia, PA; and

Resistance to the parasite is mediated by NK and T cell production of IFN-γ, but the failure to contract this response can lead to severe T cell-dependent immunopathology. Although the cytokines IL-10 and IL-27 prevent immune hyperactivity during toxoplasmosis, inhibitory receptors, expressed by NK and T cells, are also implicated in this process. The inhibitory receptor TIGIT is expressed on NK and T cells and competes with the costimulatory receptor CD226 for binding of the ligand CD155. Read More

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Fulminant hepatorenal syndrome due to Acetaminophen toxicity: A case report.

Clin Case Rep 2021 May 24;9(5):e04037. Epub 2021 Mar 24.

Toxoplasmosis Research Center Communicable Diseases Institute Iranian National Registry Center for Lophomoniasis and Toxoplasmosis Mazandaran University of Medical Sciences Sari Iran.

HRS is a rare and poor prognosis complication of chronic acetaminophen toxicity, which presents by progressive decline in renal function secondary to liver failure. Read More

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Multicenter comparative assessment of the TIB MolBiol Toxoplasma gondii detection kit and four laboratory-developed PCR assays for molecular diagnosis of toxoplasmosis.

J Mol Diagn 2021 May 31. Epub 2021 May 31.

"Molecular biology" pole of the National Reference Center (CNR) for Toxoplasmosis, Montpellier, France; Univ Montpellier, CNRS, IRD, CHU of Montpellier, MiVEGEC and Department of Parasitology-Mycology, Montpellier, France. Electronic address:

Toxoplasmosis may be a life-threatening infection, particularly in pregnancy and in immunocompromised patients. The biological diagnosis of toxoplasmosis is challenging, and has been revolutionized by molecular detection methods. Here is presented the data of a multicenter study involving four centers to assess the performances of a commercial PCR assay as compared to four in-house PCR assays using Toxoplasma gondii standards, 20 external quality control specimens and 133 clinical samples. Read More

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Comparison between Enzyme Immunoassays Performed on Samples of Dried Blood and Serum for Toxoplasmosis Prenatal Screening: Population-based Study.

Rev Bras Ginecol Obstet 2021 Jun 2. Epub 2021 Jun 2.

Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective:  Most prenatal screening programs for toxoplasmosis use immunoassays in serum samples of pregnant women. Few studies assess the accuracy of screening tests in dried blood spots, which are of easy collection, storage, and transportation. The goals of the present study are to determine the performance and evaluate the agreement between an immunoassay of dried blood spots and a reference test in the serum of pregnant women from a population-based prenatal screening program for toxoplasmosis in Brazil. Read More

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Assessment of an ELISA and IgG avidity test based on SAG1 and GRA7 proteins for discriminating between acute and chronic toxoplasmosis in humans.

J Clin Microbiol 2021 Jun 2:JCM0041621. Epub 2021 Jun 2.

Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran. Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran.

To improve serodiagnostic methods for diagnosis of acute from chronic toxoplasmosis, an economical ELISA for measuring -specific IgG, IgM and IgG avidity has been developed and assessed based on use of various antigens, including SAG1, GRA7 and a combination of SAG1 and GRA7 (SAG1+GRA7) as well as lysate antigens (TLAs). Performances of IgM, IgG and IgG avidity assays were compared to those of ELISA commercial kits and VIDAS Toxo IgG avidity. A set of 138 sera from patients with acquired infection and seronegative people were assessed. Read More

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Techniques for inactivating Toxoplasma gondii oocysts: a systematic review.

Rev Bras Parasitol Vet 2021 28;30(2):e026420. Epub 2021 May 28.

Departamento de Medicina Veterinária Preventiva, Universidade Estadual de Londrina - UEL, Londrina, PR, Brasil.

The oocyst, a resistant form of Toxoplasma gondii, plays an important role in the transmission of this protozoan. The objective of this review was to report the methods capable of inactivating oocysts through a systematic review of the literature carried out in the Scientific Electronic Library Online, Web of Science, Science Direct, PubMed and Scopus databases. The keywords searched were (((effects OR infectivity OR resistance) AND Toxoplasma) AND oocyst). Read More

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Molecular characterization of Toxoplasma gondii isolates from free-range chickens reveals new genotypes in Goiânia, Goiás, Brazil.

Rev Bras Parasitol Vet 2021 28;30(2):e000321. Epub 2021 May 28.

Laboratório de Estudos da Relação Parasito-Hospedeiro, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás - UFG, Goiânia, GO, Brasil.

The aim of this study was to evaluate the genotypic characteristics of Toxoplasma gondii isolated from free-range chickens in the metropolitan area of Goiânia, Goiás, in Brazil's central-west region. The seroprevalence rate was found to be 96%, according to an indirect hemagglutination assay. Brain and heart samples were processed by peptic digestion for a mice bioassay. Read More

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Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents.

Molecules 2021 May 31;26(11). Epub 2021 May 31.

The State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co. Ltd., Dongguan 523871, China.

The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. Read More

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Oxidative Stress as a Possible Target in the Treatment of Toxoplasmosis: Perspectives and Ambiguities.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St, 85-092 Bydgoszcz, Poland.

is an apicomplexan parasite causing toxoplasmosis, a common disease, which is most typically asymptomatic. However, toxoplasmosis can be severe and even fatal in immunocompromised patients and fetuses. Available treatment options are limited, so there is a strong impetus to develop novel therapeutics. Read More

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Proteasome Subunit Alpha Type 1 with Chitosan: A Promising Alternative to Traditional Adjuvant.

Pharmaceutics 2021 May 19;13(5). Epub 2021 May 19.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210000, China.

As an important zoonotic protozoan, () has spread around the world, leading to infections in one-third of the population. There is still no effective vaccine or medicine against , and recombinant antigens entrapped within nanospheres have benefits over traditional vaccines. In the present study, we first expressed and purified proteasome subunit alpha type 1 (TgPSA1), then encapsulated the recombinant TgPSA1 (rTgPSA1) in chitosan nanospheres (CS nanospheres, rTgPSA1/CS nanospheres) and incomplete Freund's adjuvant (IFA, rTgPSA1/IFA emulsion). Read More

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Descriptive Comparison of ELISAs for the Detection of   Antibodies in Animals: A Systematic Review.

Pathogens 2021 May 15;10(5). Epub 2021 May 15.

Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC 3030, Australia.

is the zoonotic parasite responsible for toxoplasmosis in warm-blooded vertebrates. This systematic review compares and evaluates the available knowledge on enzyme-linked immunosorbent assays (ELISAs), their components, and performance in detecting antibodies in animals. Four databases were searched for published scientific studies on and ELISA, and 57 articles were included. Read More

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The Association of IgG and Cardiovascular Biomarkers.

Int J Environ Res Public Health 2021 May 5;18(9). Epub 2021 May 5.

Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.

() is a protozoan parasite with high prevalence worldwide. More than 40 million individuals in the United States carry this parasite. infection causes toxoplasmosis, which is the leading cause of death associated with foodborne diseases in the United States. Read More

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