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Nitric Oxide 2022 Aug 15. Epub 2022 Aug 15.

Department of Biotechnology & Microbiology, School of Sciences, Noida International University, Uttar Pradesh, 203201, India. Electronic address:

Agriculture and ecosystem are negatively influenced by the abiotic stresses which create solemn pressures on plants as they are sessile in nature leading to excessive losses in economy. For maintenance of sustainable agriculture and to fulfil the cumulative call of food for rapidly growing population worldwide, it becomes crucial to protects the crop plants from climate fluctuations. Plants fight back against these challenges by generation of redox molecules comprising reactive oxygen species (ROS) and reactive nitrogen species (RNS) and cause modulation at cellular, physiological and molecular levels. Read More

Int J Biol Macromol 2022 Aug 15. Epub 2022 Aug 15.

Laboratory of Computational Modeling of Drugs, Higher Medical and Biological School, South Ural State University, Chelyabinsk 454 080, Russia; Department of Physics, Kalasalingam Academy of Research and Education, Krishnankoil 626126, Tamil Nadu, India.

The current study aimed to screen bacteriocin producing LAB from different dairy products and evaluation of their biological properties. Initially, 12 (4-chess, 4-curd, and 4-yohurt) LAB species were isolated and only 4 isolates alone were selected based on their clear yellow halo zone around the colonies in the selective medium. The selected 4 isolates were identified based on their morphological and biochemical characteristics. Read More

Int J Biol Macromol 2022 Aug 16;220:183-192. Epub 2022 Aug 16.

Institute of Nanobiomaterials and Immunology, School of Life Science, Taizhou University, Taizhou, Zhejiang 318000, China; Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Science, Heilongjiang University, Harbin, Heilongjiang 150080, China; Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:

The immunogenicity and toxicity of N-2-Hydroxypropyl trimethyl ammonium chloride chitosan/N, O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) as a universal vaccine adjuvant/delivery system remains unclear. The present study indicated that the positively charged N-2-HACC/CMCS NPs showed a regular spherical morphology, with a particle size of 219 ± 13.72 nm, zeta potential of 37. Read More

Reprod Toxicol 2022 Aug 15. Epub 2022 Aug 15.

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley - UNIVASF, Petrolina, Brazil.

This study was conducted to evaluate the protective effects of epigallocatechin-3-gallate (EGCG) against ovarian toxicity in cyclophosphamide-treated mice and to verify the possible involvement of phosphorylated Akt, FOXO3a and rpS6 in the EGCG actions. Mice received saline solution (i.p. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2022 Aug 15:109441. Epub 2022 Aug 15.

College of Urban and Rural Construction, Shaoyang University, 422099 Shaoyang, China. Electronic address:

Cadmium (Cd) is a kind of toxic heavy metal widely distributed in the environment, posing life-threatening challenges to organisms. The paddy field spider is a natural enemy of pests and an essential component of rice biodiversity. Nonetheless, the effects of Cd stress on the postembryonic development of spiders and its detailed mechanism remain to be investigated. Read More

Environ Pollut 2022 Aug 15;311:119896. Epub 2022 Aug 15.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan, 430074, China. Electronic address:

Currently little is known about the adsorption behaviors of metalloids on microplastics (MPs) and their complex toxic effects on aquatic plants. Herein, we investigated the adsorption behaviors of arsenic (As(III) and As(V)) on three types of MPs (polystyrene, polyvinyl chloride, and polyethylene) with four different particle sizes (100, 10, 1, and 0.1 μm). Read More

Mol Cell Endocrinol 2022 Aug 15:111753. Epub 2022 Aug 15.

Departments of Physiology, University of Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Ontario, Canada. Electronic address:

Accumulation of excess lipids in non-adipose tissues, such as the hypothalamus, is termed lipotoxicity and causative of free fatty acid-mediated pathology in metabolic disease. This study aimed to elucidate the molecular mechanisms behind oleate (OA)- and palmitate (PA)-mediated changes in hypothalamic neurons. Using the well-characterized hypothalamic neuronal cell model, mHypoE-46, we assessed gene changes through qRT-PCR, cell death with quantitative imaging, PA metabolism using stable isotope labeling, and cellular mechanisms using pharmacological modulation of lipid metabolism and autophagic flux. Read More

Environ Res 2022 Aug 15:113984. Epub 2022 Aug 15.

Department of Organic and Inorganic Chemistry, University of the Basque Country UPV/EHU, 48940, Leioa, Spain; Basque Center for Biophysics CSIC-UPVEH, University of Basque Country UPV/EHU, 48940, Leioa, Spain; Basque Center for Biophysics CSIC-UPVEH, University of Basque Country UPV/EHU, 48940, Leioa, Spain; IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Biscay, Spain.

Globally, pesticides are toxic substances with wide applications. However, the widespread use of pesticides has received increasing attention from regulatory agencies due to their various acute and chronic effects on multiple organisms. In this study, Quantitative Structure-Toxicity Relationship (QSTR) models were established using Multiple Linear Regression (MLR) and five Machine Learning (ML) algorithms to predict pesticide toxicity in Americamysis bahia. Read More

Environ Res 2022 Aug 15:114060. Epub 2022 Aug 15.

Guangxi Laboratory on the Study of Coral Reefs in the South China Sea; Coral Reef Research Center of China; School of Marine Sciences, Guangxi University, Nanning, 530004, China.

Recent studies have indicated that coral mucus plays an important role in the bioaccumulation of a few organic pollutants by corals, but no relevant studies have been conducted on organochlorine pesticides (OCPs). Previous studies have also indicated that OCPs widely occur in a few coral reef ecosystems and have a negative effect on coral health. Therefore, this study focused on the occurrence and bioaccumulation of a few OCPs, such as dichlorodiphenyltrichloroethanes (DDTs), hexachlorobenzene (HCB) and p,p'-methoxychlor (MXC), in the coral tissues and mucus as well as in plankton and seawater from a coastal reef ecosystem (Weizhou Island) in the South China Sea. Read More

Eur J Pharmacol 2022 Aug 15:175210. Epub 2022 Aug 15.

Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, University of Kwazulu-Natal, P.O. Box X5401, Durban, South Africa. Electronic address:

Cancer is a leading cause of increased morbidity and mortality worldwide despite advancements in diagnosis and treatment. Lack of early detection and diagnosis of different cancers and adverse effects and toxicity associated with conventional cancer treatments, such as chemotherapy and radiation, remains a problem. MicroRNAs can act as oncogenes or tumour suppressors in different types of cancers. Read More

Eur J Pharmacol 2022 Aug 15:175192. Epub 2022 Aug 15.

Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA. Electronic address:

Current medicinal treatments for diseases comprise largely of two categories: small molecule (chemical) drugs (e.g., aspirin) and larger molecules (peptides/proteins, e. Read More

Sci Total Environ 2022 Aug 15:158039. Epub 2022 Aug 15.

Civil Engineering, College of Science and Engineering, National University of Ireland, Galway, Galway H91 TK33, Ireland. Electronic address:

Autotrophic denitrification using inorganic compounds as electron donors has gained increasing attention in the field of wastewater treatment due to its numerous advantages, such as no need for exogenous organic carbon, low energy input, and low sludge production. Tetracycline (TC), a refractory contaminant, is often found coexisting with nutrients (NO and PO) in wastewater, which can negatively affect the biological nutrient removal process because of its biological toxicity. However, the performance of autotrophic denitrification under TC stress has rarely been reported. Read More

Ecotoxicol Environ Saf 2022 Aug 15;243:113966. Epub 2022 Aug 15.

The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330000, China. Electronic address:

Generally, individual microplastics (MPs) or lead (Pb) exposure could initiate ovarian toxicity. However, their combined effects on the ovary and its mechanism in mammals remained unclear. Female C57BL/6 mice were used in this study to investigate the combined ovarian toxicity of polystyrene MPs (PS-MPs, 0. Read More

Phys Med 2022 Aug 15;101:71-78. Epub 2022 Aug 15.

University of Minnesota Medical School, 420 Delaware St SE, MMC 494, Minneapolis, MN 55455, United States.

Purpose: The aim of this study was to relate common toxicity endpoints with dose to the macula, optic disc, and lens for uveal melanoma patients treated with Iodine-125 Collaborative Ocular Melanoma Study (COMS) eye plaque brachytherapy.

Methods: A cohort of 52 patients treated at a single institution between 2005 and 2019 were retrospectively reviewed. Demographics, dosimetry, and clinical outcomes were recorded. Read More

Eur J Cancer 2022 Aug 15;174:78-80. Epub 2022 Aug 15.

2nd Dermatology Department, Aristotle University of Thessaloniki Faculty of Health Sciences, Thessaloniki, Greece.

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Aug;30(4):1040-1048

Department of Clinical Molecular Medicine of Children's Hospital in Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China,Clinical Research Unit of Children's Hospital in Shanghai Jiaotong University; Institute of Pediatric Infection, Immunity and Critical Care Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200062, China,E-mail:

Objective: To investigate the function of RAS protein on the progression of the T-ALL cell lines in vitro.

Methods: The DNA of the T-ALL cells was purified then amplified the coding regions of three RAS genes (KRAS, NRAS, HRAS) by PCR reaction. After T-A cloning, the coding regions of KRAS, NRAS and HRAS were sequenced by Sanger Sequencing. Read More

Pediatr Emerg Care 2022 Aug 17. Epub 2022 Aug 17.

Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital.

Objective: Lipid emulsion (LE) has been used to treat children with cardiovascular collapse induced by toxic doses of nonlocal anesthetics with high lipid solubility. We aimed to analyze case reports on LE administration for resuscitation of toxicity induced by these drugs in pediatric patients.

Methods: Case reports involving pediatric patients undergoing LE treatment for toxicity caused by nonlocal anesthetic drugs until December 31, 2021, were searched through PubMed and Scopus using the following terms: "toxicity, or intoxication, or poisoning, or overdose" and "LE or intralipid. Read More

Adv Healthc Mater 2022 Aug 18:e2201378. Epub 2022 Aug 18.

Department of Materials, Department of Bioengineering, and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.

Polyurethane-based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, we present a simple method for synthesizing and casting biocompatible polyurethane-poly(ethylene glycol) (PU-PEG) hydrogels with tunable mechanical properties, non-fouling characteristics, and sustained tolerability as an implantable material or coating. The hydrogels are synthesized via a simple one-pot method using commercially available precursors and low toxicity solvents and reagents, yielding a consistent and biocompatible gel platform primed for long-term biomaterial applications. Read More

Am J Manag Care 2022 Aug;28(8):398-402

University of Michigan Medical School, 300 N Ingalls St, Room 6E18, Ann Arbor, MI 48109-5456. Email:

Objectives: Many patients report financial stress following hospitalization for COVID-19. Although many COVID-19 survivors require extensive care after discharge, the degree to which this care contributes to financial stress is unclear. Using national data, we assessed out-of-pocket spending during the 180 days after discharge among patients hospitalized for COVID-19. Read More

Cancer Immunol Res 2022 Aug 18. Epub 2022 Aug 18.

Vir Biotechnology (Switzerland), San Francisco, CA, United States.

Novel therapeutic approaches combining immune checkpoint inhibitors are needed to improve clinical outcomes for patients with cancer. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint molecule that inhibits T-cell activity and antitumor immune responses, acting through an independent mechanism from that of programmed death-1 (PD-1) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4). Here, we describe the development and preclinical characterization of relatlimab, a human antibody that binds to human LAG-3 with high affinity and specificity to block the interaction of LAG-3 with the ligands MHC-II and fibrinogen like protein-1, and to reverse LAG-3-mediated inhibition of T-cell function in vitro. Read More

Anim Biotechnol 2022 Aug 18:1-17. Epub 2022 Aug 18.

Immunity Department, Animal Reproduction Research Institute (ARRI), Agriculture Research Center (ARC), Giza, Egypt.

This study investigated the role of ξ Potential on Monometallic (MM) and Bimetallic (BM) Calcium Oxide/Magnetite Iron Oxides nanoparticles to stimulate the immune response. Metallic nanoparticles (MNPs) were biosynthesis using S48. MNPs characterization was carried out by UV-Vis spectra, XRD analysis, Zeta potential and Particles size, SEM-EDS, and TEM, and the concentrations were calculated by ICP-AES. Read More

PLoS One 2022 18;17(8):e0269739. Epub 2022 Aug 18.

Department of Bioinformatics & Biotechnology, Government College University Faisalabad-Pakistan, Faisalabad, Pakistan.

Hypertension (HTN) is a major risk factor for cardiovascular and renal diseases, cerebrovascular accidents (CVA) and a prime underlying cause of worldwide morbidity and mortality. Hypertension is a complex condition and a strong interplay of multiple genetic, epigenetic and environmental factors is involved in its etiology. Previous studies showed an association of overexpression of genes with hypertension. Read More

Small 2022 Aug 18:e2203506. Epub 2022 Aug 18.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Lab of Fine Chemistry, School of Chemical Engineering and Technology, Hainan University, Haikou, 570228, China.

Ethanol as a fuel for direct ethanol fuel cells (DEFCs) has the advantages of being highly energetic, environmentally friendly, and low-cost, while the slow anodic ethanol oxidation reaction (EOR), intermediate poisoning effect, and incomplete oxidation of ethanol became obstacles to the development of DEFCs. Herein, a 2D ternary cyclic Pd Pt Rh nanorings (NRs) catalyst with efficient EOR performance is prepared via a facile one-pot solvothermal approach, and systematic studies are carried out to reveal the mechanisms of the enhanced performance and C-C bond selectivity. In particular, the optimized catalyst exhibits impressive mass activity, stability, toxicity resistance, and C-C bond cleavage ability. Read More

ACS Nano 2022 Aug 18. Epub 2022 Aug 18.

Howard Hughes Medical Institute, Cambridge, Massachusetts 02139, United States.

Antimicrobial peptides (AMPs) constitute a promising class of alternatives to antibiotics to curb antimicrobial resistance. Nonetheless, their utility as a systemic agent is hampered by short circulation time and toxicity. Infection sites, analogous to tumors, harbor an aberrant microenvironment that has the potential to be exploited to develop conditionally activated therapeutics with an improved therapeutic index. Read More

Clin Exp Metastasis 2022 Aug 18. Epub 2022 Aug 18.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum - Bologna University, Bologna, Italy.

Androgen deprivation therapy (ADT) is the standard treatment of metastatic prostate cancer (PCa). However, metastases-directed therapies can delay the initiation or switch of systemic treatments and allow local control (LC) and prolonged progression-free survival (PFS), particularly in patients with lymph nodes (LN) oligometastases. We performed a systematic review on stereotactic body radiotherapy (SBRT) in this setting. Read More

Environ Sci Pollut Res Int 2022 Aug 18. Epub 2022 Aug 18.

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University, P.O Box 21545, Alexandria, Egypt.

The in vivo effect of the oral sublethal doses of 3.014 mg kg of IMI (1/25 LD) for 1, 7, 14, and 28 days every other day on Japanese quail was investigated. The results revealed that certain biomarkers in the selected tissues of the quail such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), aminotransaminases (alanine aminotransferase, ALT, and aspartate aminotransaminase, AST), phosphatases (acid phosphatase, ACP, and alkaline phosphatase, ALP), lactate dehydrogenase (LDH), adenosine-triphosphatase (ATPase), glutathione-S-transferase (GST), lipid peroxidation (LPO), and blood glucose showed significant inductions, while significant reductions in the levels of glutathione-reduced (GSH), deoxyribonucleic acid (DNA), and ribonucleic acid (RNA) were noticed. Read More

Support Care Cancer 2022 Aug 18. Epub 2022 Aug 18.

The Ottawa Hospital Cancer Center, Ottawa, ON, Canada.

Rationale: Patient support lines (PSLs) assist in triaging clinical problems, addressing patient queries, and navigating a complex multi-disciplinary oncology team. While providing support and training to the nursing staff who operate these lines is key, there is limited data on their experience and feedback.

Methods: We conducted a cross-sectional study of oncology nurses' (ONs') perspectives on the provision of care via PSLs at a tertiary referral cancer center via an anonymous, descriptive survey. Read More

Clin Cancer Res 2022 Aug 18. Epub 2022 Aug 18.

Yokohama Municipal Citizen's Hospital, yokohama, Kanagawa, Japan.

Purpose: The addition of cytotoxic chemotherapy to immune checkpoint inhibitor (ICI) may enhance anti-tumor effects. We conducted an open-label randomized phase II/III study to evaluate nivolumab + docetaxel combination therapy in comparison to nivolumab monotherapy for previously treated ICI-naïve non-small-cell lung cancer (NSCLC).

Patients And Methods: The primary endpoint of the phase III study was overall survival (OS), and the secondary endpoints included progression-free survival (PFS), overall response rate (ORR), and toxicity. Read More

J Med Food 2022 Aug;25(8):845-852

Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.

Obesity-associated nonalcoholic fatty liver disease (NAFLD) is characterized by excessive intrahepatic lipid accumulation. Despite the increasing prevalence of NAFLD and obesity, the pathogenesis of NAFLD has not yet been clearly elucidated. Prohibitin 1 (PHB1) is mainly expressed in the inner membrane of mitochondria and is known to play an important role in hepatocyte proliferation and lipid metabolism. Read More

Mol Pharm 2022 Aug 18. Epub 2022 Aug 18.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.

Visceral leishmaniasis (VL) is one of the most fatal and neglected tropical diseases caused by donovani (). The applications of currently available chemotherapy (amphotericin B, miltefosine, and others) in VL treatment have been limited due to their poor bioavailability, unfavorable toxicity profile, and prolonged parenteral dosing. Quercetin (QT), a potent natural antioxidant, is a prominent target when conducting investigations on alternative therapies against infections. Read More