749,122 results match your criteria Toxicity Warfarins and Superwarfarins


Nanocellulose for peripheral nerve regeneration in rabbits using citric acid as crosslinker with chitosan and freeze/thawed PVA.

Biomed Mater 2021 Jul 30. Epub 2021 Jul 30.

UFCG, Programa de Pós-Graduação em Medicina Veterinária - PPGMV, Universidade Federal de Campina Grande, Campina Grande, PB, 58429-900, BRAZIL.

This work investigates peripheral nerve regeneration using membranes consisting of pure chitosan, which was further blended with nanofibrillated cellulose, with citric acid as crosslinker, with posterior addition of polyvinyl alcohol, with subsequent freeze thawing. Nanocellulose improves the mechanical and thermal resistance, as well as flexibility of the film, which is ideal for the surgical procedure. The hydrogel presented a slow rate of swelling, which is adequate for cell and drug delivery. Read More

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Self-assembled micelles of the (lipo) glycopeptides, teicoplanin, as taxane nanocarriers.

Nanotechnology 2021 Jul 30. Epub 2021 Jul 30.

Centro de Excelencia en Productos y Procesos Cordoba, Pabellon Ceprocor. Santa Maria de Punilla, Cordoba, 5004, ARGENTINA.

The use of nanoparticles is one of the strategies currently studied to minimize the toxicity and lack of tissue specificity of many cancer drugs used in chemotherapy. In this research the physicochemical and biological behavior of a novel self-assembled nanostructure of the antibiotic Teicoplanin (Teico) was characterized as a nanocarrier system for solubilizing highly hydrophobic drugs like Paclitaxel (Ptx) in aqueous media. The Teico micelles were loaded with Ptx in DMSO or PEG-400. Read More

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Effect of root surface charge on the absorption and accumulation of Cu(II) by different japonica and indica rice varieties under acidic conditions.

Ecotoxicol Environ Saf 2021 Jul 27;223:112547. Epub 2021 Jul 27.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, P.O. Box 821, Nanjing, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Excessive amounts of copper (Cu) in soils causes toxic effects on plants. In this study, 58 rice cultivars were classified into tolerant, moderately tolerant, and susceptible types for Cu(II) toxicity based on 50% germination (LC). Nine japonica rice varieties (three each from the tolerant, moderately tolerant, and susceptible groups) and six indica rice varieties (three from the moderately tolerant and susceptible groups) were selected for the hydroponics experiments. Read More

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Simultaneous determination of tetra-, penta- and hexachlorobutadienes in shellfish by gas chromatography-triple quadrupole mass spectrometry.

Environ Pollut 2021 Jul 24;289:117845. Epub 2021 Jul 24.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310000, China.

Polychloro-1,3-butadienes (polyCBDs) are attracting increasing concern due to their high toxicity. However, research on multiple polyCBDs in aquatic biota is still extremely limited. In this study, a sensitive method for simultaneous determination of nine polyCBD (Cl-Cl) congeners, including six tetrachlorobutadiene (TeCBD) isomers, two pentachlorobutadiene (PeCBD) isomers, and hexachlorobutadiene (HCBD), in shellfish was developed based on accelerated solvent extraction (ASE), solid-phase extraction (SPE) clean-up and gas chromatography-triple quadrupole mass spectrometry (GC-QqQ-MS/MS). Read More

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Characterization of PFOS toxicity on in-vivo and ex-vivo mouse pancreatic islets.

Environ Pollut 2021 Jul 26;289:117857. Epub 2021 Jul 26.

Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Considerable human data have shown that the exposure to perfluorooctane sulfonate (PFOS) correlates to the risk of metabolic diseases, however the underlying effects are not clearly elucidated. In this study, we investigated the impacts of PFOS treatment, using in-vivo, ex-vivo and in-vitro approaches, on pancreatic β-cell functions. Mice were oral-gavage with 1 and 5 μg PFOS/g body weight/day for 21 days. Read More

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Olaparib in combination with pegylated liposomal doxorubicin for platinum-resistant ovarian cancer regardless of BRCA status: a GEICO phase II trial (ROLANDO study).

ESMO Open 2021 Jul 27;6(4):100212. Epub 2021 Jul 27.

Department of Medical Oncology Department, Clínica Universidad de Navarra, Madrid, Spain.

Background: There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status.

Patients And Methods: Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Read More

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Biomarker-based assessment of sublethal toxicity of organic UV filters (ensulizole and octocrylene) in a sentinel marine bivalve Mytilus edulis.

Sci Total Environ 2021 Jul 26;798:149171. Epub 2021 Jul 26.

Department of Marine Biology, Institute for Biological Sciences, University of Rostock, Rostock, Germany; Department of Maritime Systems, Interdisciplinary Faculty, University of Rostock, Rostock, Germany. Electronic address:

The global occurrence of organic UV filters in the marine environment is of increasing ecotoxicological concern. Here we assessed the toxicity of UV filters ensulizole and octocrylene in the blue mussels Mytilus edulis exposed to 10 or 100 μg l of octocrylene and ensulizole for two weeks. An integrated battery of biochemical and molecular biomarkers related to xenobiotics metabolism and cellular toxicity (including oxidative stress, DNA damage, apoptosis, autophagy and inflammation) was used to assess the toxicity of these UV filters in the mussels. Read More

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Combining yeast MBR, Fenton and nanofiltration for landfill leachate reclamation.

Waste Manag 2021 Jul 27;132:105-114. Epub 2021 Jul 27.

Department of Sanitary and Environmental Engineering - Federal University of Minas Gerais, P.O. Box 1294, ZIP 30.270-901, Belo Horizonte, MG, Brazil.

This study investigated the best way to combine nanofiltration (NF) and Fenton with membrane bioreactor inoculated with Saccharomyces cerevisiae (MBRy) for the treatment of landfill leachate, aiming at compliance with legislation and water reuse. Firstly, the permeate from MBRy was treated by Fenton process followed by NF (MBRy - Fenton - NF). Another alternative evaluated was the polishment of MBRy permeate by NF and treatment of NF concentrate by Fenton process (MBRy - NF - Fenton). Read More

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Heterogeneous photocatalysis of moxifloxacin at a pilot solar compound parabolic collector: Elimination of the genotoxicity.

J Environ Manage 2021 Jul 27;297:113296. Epub 2021 Jul 27.

Universidade Federal Do Rio Grande Do Sul (UFRGS), Programa de Pós-Graduação Em Engenharia de Minas, Metalúrgica e de Materiais (PPGE3M), Av. Bento Gonçalves, 9500, Porto Alegre, RS, Brazil.

Photocatalysis has been applied for the elimination or reduction concentration of emerging pollutants in water. One of them, is the moxifloxacin (MOX), a fluoroquinolone that have a potential to develop resistant bacteria and have been present toxicity. The MOX achieves the environment due to inefficient wastewater treatment and incorrect disposal. Read More

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Effects of ultraviolet-filters on Daphnia magna development and endocrine-related gene expression.

Aquat Toxicol 2021 Jul 17;238:105915. Epub 2021 Jul 17.

Center for Environmental and Human Toxicology, University of Florida.

Ultraviolet (UV) filters are emerging contaminants of concern that are widely spread throughout the aquatic environment. Many organic UV filters are endocrine disrupting compounds (EDCs) in vertebrates. However, few studies have assessed their effects on invertebrates. Read More

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PCNA inhibition enhances the cytotoxicity of β-lapachone in NQO1-Positive cancer cells by augmentation of oxidative stress-induced DNA damage.

Cancer Lett 2021 Jul 27. Epub 2021 Jul 27.

Department of Radiation Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Electronic address:

β-Lapachone is a classic quinone-containing antitumor NQO1-bioactivatable drug that directly kills NQO1-overexpressing cancer cells. However, the clinical applications of β-lapachone are primarily limited by its high toxicity and modest lethality. To overcome this side effect and expand the therapeutic utility of β-lapachone, we demonstrate the effects of a novel combination therapy including β-lapachone and the proliferating cell nuclear antigen (PCNA) inhibitor T2 amino alcohol (T2AA) on various NQO1 cancer cells. Read More

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TRAIL produced by SAM-1-activated CD4 and CD8 subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors.

Toxicol Appl Pharmacol 2021 Jul 27:115656. Epub 2021 Jul 27.

Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, Liaoning, China.

Bacterial superantigens potently activate conventional T-cells to induce massive cytokine production and mediate tumor cell death. To engineer superantigens for immunotherapy against tumors in clinic, we previously generated SAM-1, a staphylococcal enterotoxins C2 (SEC2) mutant, that exhibited significantly reduced toxicity but maintained the superantigen activity in animal models. This present study aimed to investigate whether SAM-1 activates T cells and induces apoptosis in human tumor cells. Read More

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Assessment of toxicity and potential health risk from persistent pesticides and heavy metals along the Delhi stretch of river Yamuna.

Environ Res 2021 Jul 27:111780. Epub 2021 Jul 27.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

The present study aims at the assessment of environmental quality of the most polluted stretch of river Yamuna along the megacity of Delhi. The study was conducted in order to examine toxicity and health hazards associated with persistent pollutants present in the fluvial ecosystem. Eighty four sediment and 56 vegetable samples from same locations were collected from the Delhi segment of river Yamuna flood plain in order to examine 20 organochlorine pesticides (OCPs) and 9 heavy metals (Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn). Read More

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Progressive multifocal leukoencephalopathy in patients treated with rituximab: a 20-year review from the Southern Network on Adverse Reactions.

Lancet Haematol 2021 Aug;8(8):e593-e604

Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE, USA.

Progressive multifocal leukoencephalopathy (PML) is a serious and usually fatal CNS infection caused by the John Cunningham virus. CD4 and CD8 T-cell lymphopenia, resulting from HIV infection, chemotherapy, or immunosuppressive therapy, are primary risk factors for PML. Following its introduction in 1997, the immunomodulatory anti-CD20 monoclonal antibody, rituximab, has received regulatory approval worldwide for treatment of non-Hodgkin lymphoma, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis with polyangiitis, microscopic polyangiitis, and pemphigus vulagris. Read More

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Investigation of the effects and mechanisms of anticancer action of a Ru(II)-arene iminophosphorane compound in triple negative breast cancer cells.

ChemMedChem 2021 Jul 30. Epub 2021 Jul 30.

Brooklyn College and The Graduate Center, The City University of New York, Chemistry Department, 2900 Bedford Avenue, 11210-2889, Brooklyn, UNITED STATES.

Triple negative breast cancer (TNBC) is one of the breast cancers with poorer prognosis and survival rates. TNBC has a disproportionally high incidence and mortality in women of African descent. We report on the evaluation of Ru-IM (1) in TNBC cell lines derived from patients of European (MDA-MB-231) and African (HCC-1806) ancestry (including IC50 values, cellular and organelle uptake, cell death pathways, cell cycle, effects on migration, invasion, and angiogenesis, a preliminary proteomic analysis, and an NCI 60 cell-line panel screen). Read More

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14-Day Nose-Only Inhalation Toxicity and Haber's Rule Study of NNK in Sprague-Dawley Rats.

Toxicol Sci 2021 Jul 30. Epub 2021 Jul 30.

National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR.

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. However, repeated inhalation toxicity data on NNK, which is more directly relevant to cigarette smoking, are currently limited. In the present study, the subacute inhalation toxicity of NNK was evaluated in Sprague Dawley rats. Read More

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Efficient mineralization of TBBPA via an integrated photocatalytic reduction/oxidation process mediated by MoS/SnInS photocatalyst.

Chemosphere 2021 Jul 13;285:131542. Epub 2021 Jul 13.

Indoor Environment Engineering Research Center of Fujian Province, Fujian University of Technology, Fuzhou, 350118, China. Electronic address:

Currently, Tetrabromobisphenol A (TBBPA) has been regarded as an emerging organic pollutant and efficient TBBPA elimination technology has been attracting increasing attention. In this work, a novel photocatalyst, MoS/SnInS, was synthesized through hydrothermal method by introducing few-layer MoS nanosheets and then employed to establish an integrated photocatalytic reduction/oxidation system for the remediation of TBBPA under visible light. The characterization results demonstrated that the few-layer MoS nanosheets were well combined with SnInS and significantly lowered the recombination rate of the photo-induced electron and holes, leading to outstanding photocatalytic performance of MoS/SnInS composite. Read More

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Combined exposure to microplastics and zinc produces sex-specific responses in the water flea Daphnia magna.

J Hazard Mater 2021 Jul 16;420:126652. Epub 2021 Jul 16.

Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

Microplastics are ubiquitous environmental pollutants and a great threat to the aquatic environment. Due to their small size (ranging from 1 µm to 5 mm), microplastics be easily ingested by a wide range of organisms and can serve as a vector for various contaminants. In this study, additive or possible synergistic effects of microplastics and zinc were demonstrated through sex-specific alterations in behavior, redox status, and modulation of detoxification-related genes in Daphnia magna, with males being more sensitive than females with stronger modulations of antioxidant responses, particularly on glutathione S-transferases expressions. Read More

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Removal of disinfection by-product precursors by Al-based coagulants: A comparative study on coagulation performance.

J Hazard Mater 2021 Jul 3;420:126558. Epub 2021 Jul 3.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Ministry of Education Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, China; International Joint Research Center for Sustainable Urban Water System, Tongji University, Shanghai 200092, China. Electronic address:

Coagulation is well-established for controlling regulated disinfection by-products (DBPs), but its effectiveness for controlling unregulated DBPs remains unclear. The efficiency of coagulation in controlling unregulated DBPs requires clarification owing to their relatively high toxicity. In this study, three Al-based coagulants, aluminum sulfate (Alum), polyaluminum chloride (PAC), and a novel type of covalently bond hybrid coagulant (CBC, synthesized using AlCl) were selected, and the coagulation performance of these Al-based coagulants in controlling DBPs and DBP-associated toxicity was compared over 5 classes of DBPs, including trihalomethanes, haloacetic acids, haloacetaldehydes, haloacetonitriles, and halonitromethanes. Read More

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Reduction of antibiotic resistance determinants in urban wastewater by ozone: Emphasis on the impact of wastewater matrix towards the inactivation kinetics, toxicity and bacterial regrowth.

J Hazard Mater 2021 Jun 29;420:126527. Epub 2021 Jun 29.

Department of Civil and Environmental Engineering, School of Engineering, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus; Nireas-International Water Research Centre, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus. Electronic address:

This study investigated the impact of bench-scale ozonation on the inactivation of total cultivable and antibiotic-resistant bacteria (faecal coliforms, Escherichia coli, Pseudomonas aeruginosa, Enterococcus spp., and total heterotrophs), and the reduction of gene markers (16S rRNA and intl1) and antibiotic resistance genes (qacEΔ1, sul1, aadA1 and dfrA1) indigenously present in wastewater effluents treated by membrane bioreactor (MBR) or conventional activated sludge (CAS). The Chick-Watson model-predicted ozone exposure (CT) requirements, showed that higher CT values were needed for CAS- than MBR-treated effluents to achieve a 3-log reduction of each microbial group, i. Read More

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Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure model.

J Hazard Mater 2021 Jul 14;420:126637. Epub 2021 Jul 14.

Telethon Kids Institute, Centre for Health Research, The University of Western Australia, Nedlands, Perth 6009, Western Australia, Australia; St. John of God Hospital, Subiaco, Perth 6008, Western Australia, Australia.

Background: Biodiesel is promoted as a sustainable replacement for commercial diesel. Biodiesel fuel and exhaust properties change depending on the base feedstock oil/fat used during creation. The aims of this study were, for the first time, to compare the exhaust exposure health impacts of a wide range of biodiesels made from different feedstocks and relate these effects with the corresponding exhaust characteristics. Read More

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Insights into the impacts of bioturbation by multiple benthic organisms on the bioavailability and toxic effects of perfluorooctane sulfonate in sediment.

J Hazard Mater 2021 Jul 17;420:126675. Epub 2021 Jul 17.

Key Laboratory of Pollution Processes and Environmental Criteria of Ministry of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:

Sediment is an important reservoir for perfluorooctane sulfonate (PFOS) in the environment, which likely poses adverse effects to benthos. In this study, the impacts of bioturbation of three benthic organisms, i.e. Read More

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Probiotics and gut microbiome - Prospects and challenges in remediating heavy metal toxicity.

J Hazard Mater 2021 Jul 17;420:126676. Epub 2021 Jul 17.

Centre for Innovation and Translational Research, CSIR, Indian Institute for Toxicology Research, Lucknow 226001, Uttar Pradesh, India; Centre for Energy and Environmental Sustainability, Lucknow 226029, Uttar Pradesh, India. Electronic address:

The gut microbiome, often referred to as "super organ", comprises up to a hundred trillion microorganisms, and the species diversity may vary from person to person. They perform a decisive role in diverse biological functions related to metabolism, immunity and neurological responses. However, the microbiome is sensitive to environmental pollutants, especially heavy metals. Read More

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Omics technologies used in pesticide residue detection and mitigation in crop.

J Hazard Mater 2021 Jul 10;420:126624. Epub 2021 Jul 10.

Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University, Zhengzhou 450002, China; Biological Security and Sustainability (BioSES) Research Interest Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia. Electronic address:

In agriculture, the convenience and efficacy of chemical pesticides have become inevitable to manage cultivated crop production. Here, we review the worldwide use of pesticides based on their categories, mode of actions and toxicity. Excessive use of pesticides may lead to hazardous pesticide residues in crops, causing adverse effects on human health and the environment. Read More

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Chronic cereulide exposure causes intestinal inflammation and gut microbiota dysbiosis in mice.

Environ Pollut 2021 Jul 19;288:117814. Epub 2021 Jul 19.

Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, 510642, PR China; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, Guangdong, 510642, PR China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, 510642, PR China. Electronic address:

Known as a cause of food poisoning, Bacillus cereus (B. cereus) is widespread in nature. Cereulide, the heat-stable and acid-resistant emetic toxin which is produced by some B. Read More

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Prioritization and environmental risk assessment of pharmaceuticals mixtures from Brazilian surface waters.

Environ Pollut 2021 Jul 19;288:117803. Epub 2021 Jul 19.

Department of Sanitary and Environmental Engineering, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The present study provides an environmental risk assessment of the pharmaceutical mixtures detected in Brazilian surface waters, based on Toxic Units and Risk Quotients. Furthermore, the applicability of a previously proposed prioritization methodology was evaluated. The pharmaceuticals were classified according to their properties (occurrence, persistence, bioaccumulation, and toxicity) and the contribution of the prioritized compounds to the mixture risk was determined. Read More

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A chemical genetic approach using genetically encoded reporters to detect and assess the toxicity of plant secondary metabolites against bacterial pathogens.

J Hazard Mater 2021 Jun 12;418:126399. Epub 2021 Jun 12.

Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand 247667, India. Electronic address:

Plant secondary metabolites are emerging as attractive alternatives in the development of therapeutics against infectious and chronic diseases. Due to the present pandemic, therapeutics showing toxicity against bacterial pathogens and viruses are gaining interest. Plant metabolites of terpenoid and phenylpropanoid categories have known antibacterial and antiviral properties. Read More

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Effects of cloransulam-methyl and diclosulam on soil nitrogen and carbon cycle-related microorganisms.

J Hazard Mater 2021 Jun 12;418:126395. Epub 2021 Jun 12.

College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China. Electronic address:

Cloransulam-methyl and diclosulam are applied to soybean fields to control broad-leaved weeds. These herbicides have become a focus of attention because of their low application dose and high-efficiency advantages. However, the effects of these two herbicides on soil microorganisms are unknown. Read More

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Emission-to-ash detoxification mechanisms of co-combustion of spent pot lining and pulverized coal.

J Hazard Mater 2021 Jun 11;418:126380. Epub 2021 Jun 11.

Guangdong Provincial Key Laboratory of Radioactive and Rare Resource Utilization, Guangdong Provincial Institute of Mining Applications, Shaoguan 512026, China.

In response to the global initiative for greenhouse gas emission reduction, the co-combustion of coal and spent pot lining (SPL) may cost-effectively minimize waste streams and environmental risks. This study aimed to quantify the emission-to-ash detoxification mechanisms of the co-combustion of SPL and pulverized coal (PC) and their kinetics, gas emission, fluorine-leaching toxicity, mineral phases, and migrations. The main reaction covered the ranges of 335-540 °C and 540-870 °C while the interactions occurred at 360-780 °C. Read More

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Silver nanoparticles in aquatic sediments: Occurrence, chemical transformations, toxicity, and analytical methods.

J Hazard Mater 2021 Jun 9;418:126368. Epub 2021 Jun 9.

Key Laboratory of Water and Sediment Sciences of Ministry of Education, State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, People's Republic of China. Electronic address:

Sediments represent the major sink for released silver nanoparticles (AgNPs) in aquatic environments. It is well known that the environmental behavior and toxicity of AgNPs in sediments are governed by their specific chemical species instead of their total concentration. This review focuses on various chemical transformations of AgNPs in sediments, which have not been well outlined before. Read More

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