3 results match your criteria Toxicity Warfarin and Superwarfarins

  • Page 1 of 1

The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats.

Toxicol Sci 2017 09;159(1):224-237

Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612.

Superwarfarins are very long-lasting rodenticides effective in warfarin-resistant rodents at extremely low doses. The consequences of chronic superwarfarin levels in tissues, due to biological half-lives on the order of 20 days, have not been examined. We now characterized the neurological effects of brodifacoum (BDF), one of the most widely used superwarfarins, in adult male Sprague Dawley rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfx134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837443PMC
September 2017
9 Reads

Membrane Cholesterol Modulates Superwarfarin Toxicity.

Biophys J 2016 04;110(8):1777-1788

Department of Anesthesiology, University of Illinois-Chicago, Chicago, Illinois; Jesse Brown VA Medical Center, Chicago, Illinois. Electronic address:

Superwarfarins are modified analogs of warfarin with additional lipophilic aromatic rings, up to 100-fold greater potency, and longer biological half-lives. We hypothesized that increased hydrophobicity allowed interactions with amphiphilic membranes and modulation of biological responses. We find that superwarfarins brodifacoum and difenacoum increase lactate production and cell death in neuroblastoma cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850322PMC
April 2016
9 Reads
  • Page 1 of 1