Biophys J 2016 04;110(8):1777-1788
Department of Anesthesiology, University of Illinois-Chicago, Chicago, Illinois; Jesse Brown VA Medical Center, Chicago, Illinois. Electronic address:
Superwarfarins are modified analogs of warfarin with additional lipophilic aromatic rings, up to 100-fold greater potency, and longer biological half-lives. We hypothesized that increased hydrophobicity allowed interactions with amphiphilic membranes and modulation of biological responses. We find that superwarfarins brodifacoum and difenacoum increase lactate production and cell death in neuroblastoma cells. Read More