20,111 results match your criteria Toxicity Vitamin


Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO) exposure on Zebrafish (Danio rerio).

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand; Science and Technology Research Institute, Chiang Mai University, 239 Huay keaw Rd., Suthep, Muang, Chiang Mai 50200, Thailand. Electronic address:

The present study evaluated silver nanoparticle (AgNPs) toxicity using biomarkers of oxidative and metabolic stress, immunological impairment and cellular damage in zebrafish (Danio rerio), as well as the optimal dose of vitamin E neutralizing undesirable effects. Fish were fed for ten days and eight study groups were investigated: controls, AgNPs exposure alone (1.5 mg L) and combined with three different vitamin E doses (1. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.04.004DOI Listing

Iatrogenic pediatric hydroxocobalamin overdose.

Am J Emerg Med 2019 Apr 10. Epub 2019 Apr 10.

University of Washington, Department of Emergency Medicine, United States of America.

Introduction: Hydroxocobalamin, a precursor molecule to vitamin B12, has emerged as the preferred empiric treatment for patients rescued from enclosed-space fires with concern for inhalational injury and potential concomitant cyanide toxicity. Limited data exist on the effects of hydroxocobalamin toxicity, particularly in pediatric patients.

Case Report: We report a case of a healthy three-year old girl who was rescued from an apartment fire and electively intubated by prehospital providers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757193023
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http://dx.doi.org/10.1016/j.ajem.2019.04.012DOI Listing
April 2019
1 Read

Larvicidal activity of extract against mosquitoes.

J Vector Borne Dis 2018 Oct-Dec;55(4):282-290

World Health Organization, SEARO, New Delhi, India.

Background & Objectives: Vector control strategies play significant role in reducing the transmission of malaria, dengue and other vector-borne diseases. The control of vector population using synthetic insecticides has resulted in development of insecticide resistance and negative effects on humans and environment. The present investigation evaluated the larvicidal potential of methanol, dichloromethane and hexane extracts of leaves and seeds of Ricinus communis (castor) plant against the early IV instar larvae of the dengue vector, Aedes aegypti, and malaria vector, Anopheles culicifacies. Read More

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http://dx.doi.org/10.4103/0972-9062.256563DOI Listing
April 2019
2 Reads

The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis.

Andrologia 2019 Apr 17:e13292. Epub 2019 Apr 17.

Faculty of Medicine, Department of Biostatistics, Inonu University, Malatya, Turkey.

Thirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant-antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. Read More

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http://dx.doi.org/10.1111/and.13292DOI Listing
April 2019
1 Read

Disodium Cantharidinate and Vitamin B6 Injection Adjunct with Platinum-Based Chemotherapy for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis.

Evid Based Complement Alternat Med 2019 12;2019:9386273. Epub 2019 Mar 12.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Purpose: Disodium cantharidinate and vitamin B6 (DCVB6) injection is effective and widely used for the clinical treatment of non-small-cell lung cancer (NSCLC). This meta-analysis aimed to provide evidence-based medical data for clinical treatment with DCVB6 injection.

Methods: We searched 7 medical databases up to January 2018 for all randomized controlled trials (RCTs) based on DCVB6 injection combined with chemotherapy in patients with NSCLC. Read More

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http://dx.doi.org/10.1155/2019/9386273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434307PMC
March 2019
1 Read

Amelioration of PM-induced lung toxicity in rats by nutritional supplementation with fish oil and Vitamin E.

Respir Res 2019 Apr 16;20(1):76. Epub 2019 Apr 16.

International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, 601 Jinsui Street, Xinxiang, 453003, Henan Province, China.

Background: Exposure to fine particulate matter (PM) has been associated with respiratory morbidity and mortality. Identification of interventional measures that are efficacious against PM-induced toxicity may provide public health benefits. This study examined the inhibitory effects of nutritional supplementation with fish oil as a source of omega-3 fatty acids and vitamin E (Vit E) on PM-induced lung toxicity in rats. Read More

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http://dx.doi.org/10.1186/s12931-019-1045-7DOI Listing
April 2019
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Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits.

Environ Sci Pollut Res Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Zoology, University of the Punjab, Lahore, Pakistan.

Cadmium and mercury are non-biodegradable toxic metals that may cause many detrimental effects to the thyroid gland and blood. Vitamin C has been found to be a significant chain-breaking antioxidant and enzyme co-factor against metal toxicity and thus make them less available for animals. The current study was performed to find the effect of individual metals (cadmium and mercury), their co-administration, and the ameliorative effects of vitamin C on some of the parameters that indicate oxidative stress and thyroid dysfunction. Read More

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http://dx.doi.org/10.1007/s11356-019-04886-9DOI Listing
April 2019
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Vitamins C and E alone and in combination partly protect against chronic ethanol-induced toxicity in rat erythrocytes.

Int J Vitam Nutr Res 2019 Apr 16:1-9. Epub 2019 Apr 16.

2 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Oxidative stress is part of the mechanisms involved in ethanol toxicity. We investigated effects of vitamins C (VC), E (VE) and the combination of VC+VE on chronic ethanol-induced toxicity in rat erythrocytes. The following groups were treated for 30 days: control (C), VC (200 mg/kg), VE (200 mg/kg), VC (200 mg/kg) + VE (200 mg/kg), ethanol 4 g/kg, ethanol + VC, ethanol + VE and ethanol + VC + VE. Read More

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https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000551
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http://dx.doi.org/10.1024/0300-9831/a000551DOI Listing
April 2019
2 Reads

Food Supplements to Mitigate Detrimental Effects of Pelvic Radiotherapy.

Microorganisms 2019 Apr 3;7(4). Epub 2019 Apr 3.

Interdisciplinary Biosciences Group, Belgian Nuclear Research Centre (SCK•CEN), Boeretang 200, 2400 Mol, Belgium.

Pelvic radiotherapy has been frequently reported to cause acute and late onset gastrointestinal (GI) toxicities associated with significant morbidity and mortality. Although the underlying mechanisms of pelvic radiation-induced GI toxicity are poorly understood, they are known to involve a complex interplay between all cell types comprising the intestinal wall. Furthermore, increasing evidence states that the human gut microbiome plays a role in the development of radiation-induced health damaging effects. Read More

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https://www.mdpi.com/2076-2607/7/4/97
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http://dx.doi.org/10.3390/microorganisms7040097DOI Listing
April 2019
2 Reads

Reducing oxidative toxicity of L-dopa in combination with two different antioxidants: an essential oil isolated from Rosa Damascena Mill., and vitamin C.

Toxicol Rep 2019 22;6:267-271. Epub 2019 Mar 22.

Department of chemistry and biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.

Parkinson disease (PD) is a multifactorial disease that takes a leading place among contemporary frequent diseases of the central nervous system (CNS) with not well-established mechanism. One of the most popular and effective therapy for patients with PD is Levodopa (L-dopa), but clinical effect of the drug diminished by motor complications resulting from prolonged treatment. Due to the L-dopa neurotoxic effect in the disease treatment, the L-dopa administration is delayed as long as possible in order to avoid side effects. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444129PMC
March 2019
1 Read

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.

Environ Int 2019 Apr 10;127:503-513. Epub 2019 Apr 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, USA.

Background: Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite the abundance of observational and controlled studies reporting associations between traffic sources and asthma exacerbation and hospitalizations.

Objectives: To identify molecular pathways perturbed following traffic pollution exposures, we analyzed data as part of the Atlanta Commuters Exposure (ACE-2) study, a crossover panel of commuters with and without asthma.

Methods: We measured 27 air pollutants and conducted high-resolution metabolomics profiling on blood samples from 45 commuters before and after each exposure session. Read More

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http://dx.doi.org/10.1016/j.envint.2019.04.003DOI Listing
April 2019
1 Read

Vitamin C protects against defects induced by juglone during porcine oocyte maturation.

J Cell Physiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

Juglone, a naphthoquinone isolated from many species of the Juglandaceae family, has been used in traditional Chinese medicine for centuries because of its antiviral, antibacterial, and antitumor activities. However, the toxicity of juglone has also been demonstrated. Here, we used porcine oocytes as a model to explore the effects of juglone on oocyte maturation and studied the impact of vitamin C (VC) administration on juglone exposure-induced meiosis defects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28555
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http://dx.doi.org/10.1002/jcp.28555DOI Listing
April 2019
2 Reads

EARLY VITAMIN A SUPPLEMENTATION IMPROVES THE OUTCOME OF RETINOPATHY OF PREMATURITY IN EXTREMELY PRETERM INFANTS.

Retina 2019 Apr 5. Epub 2019 Apr 5.

Department of Neonatology, Shangqiu People's Hospital, Shangqiu, China.

Purpose: This study assessed the efficacy and safety of early vitamin A (VA) supplementation to improve outcomes of retinopathy of prematurity in extremely preterm infants.

Methods: A total of 262 eligible extremely preterm infants underwent randomization; of these, 132 were assigned to the VA group and 130 to the control group. The infants were administered a solution of VA (1,500 IU/day), added to their enteral feeds as soon as minimal feeding was introduced and continued for 28 days or until discharge. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002543DOI Listing
April 2019
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Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial.

JAMA 2019 04;321(14):1370-1379

Yale Cancer Center, New Haven, Connecticut.

Importance: In observational studies, higher plasma 25-hydroxyvitamin D (25[OH]D) levels have been associated with improved survival in metastatic colorectal cancer (CRC).

Objective: To determine if high-dose vitamin D3 added to standard chemotherapy improves outcomes in patients with metastatic CRC.

Design, Setting, And Participants: Double-blind phase 2 randomized clinical trial of 139 patients with advanced or metastatic CRC conducted at 11 US academic and community cancer centers from March 2012 through November 2016 (database lock: September 2018). Read More

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http://dx.doi.org/10.1001/jama.2019.2402DOI Listing
April 2019
2 Reads

When and How to Diagnose and Treat Vitamin D Deficiency in Adults: A Practical and Clinical Update.

J Diet Suppl 2019 Apr 7:1-19. Epub 2019 Apr 7.

b Independent Researcher , Beirut , Lebanon.

Vitamin D deficiency is considered a major public health concern. Inadequate sun exposure, limited oral intake, and impaired intestinal absorption are common risk factors for vitamin D deficiency. An increasing amount of research is aimed at answering questions regarding the most convenient test that can assess vitamin D status, the indications for screening, and finally the utility of treatments for vitamin D deficiency. Read More

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http://dx.doi.org/10.1080/19390211.2019.1577935DOI Listing
April 2019
4 Reads

Dosage considerations in the combined use of ocular-specific vitamins and nutrients and multivitamin products: A systemic review and analysis.

J Am Pharm Assoc (2003) 2019 Apr 1. Epub 2019 Apr 1.

Objectives: To provide guidance for safe and appropriate vitamin and mineral supplementation regimens for patients who use vitamins marketed for ocular use concurrently with general-purpose multivitamin (MVI) supplementation.

Data Sources: Primary and tertiary evidence was compiled from secondary literature reference databases.

Study Selection: Dosage exposure with the use of supplements marketed for the prevention of ocular disease, including those recommended by the Age-Related Eye Disease Studies (AREDS), when used in combination with conventional MVI/nutrient products was determined. Read More

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http://dx.doi.org/10.1016/j.japh.2019.01.013DOI Listing
April 2019
4 Reads

Nanocomposites as biomolecules delivery agents in nanomedicine.

J Nanobiotechnology 2019 Apr 3;17(1):48. Epub 2019 Apr 3.

Department of Applied Toxicology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str, 02-097, Warsaw, Poland.

Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range of between 1 and 100 nm. Their nano-sized dimensions, which are in the same range as those of vital biomolecules, such as antibodies, membrane receptors, nucleic acids, and proteins, allow them to interact with different structures within living organisms. Because of these features, numerous nanoparticles are used in medicine as delivery agents for biomolecules. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0479-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448271PMC
April 2019
6 Reads

Acute oral toxicity and antioxidant studies of an amine-based diselenide.

BMC Complement Altern Med 2019 Apr 3;19(1):80. Epub 2019 Apr 3.

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.

Background: Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice.

Methods: Mice were randomly divided into four groups, with each group comprising of seven animals. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2489-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448241PMC
April 2019
4 Reads

An evaluation of total 25-hydroxyvitamin D assay standardization: Where are we today?

J Steroid Biochem Mol Biol 2019 Mar 30;190:224-233. Epub 2019 Mar 30.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; OPEN, Odense Patient data Explorative Network, Odense University Hospital/Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address:

Background: Serum total 25-hydroxyvitamin D is a measure of the total circulating 25-hydroxyvitamin D concentration and is the primary measurement for estimating vitamin D status. A number of automated immunoassays are commercially available, and in an attempt to standardize the assays the Vitamin D Standardization Program (VDSP) was established in 2010. Therefore, the aim of the current project is to evaluate the status of the standardization of routinely used 25-hydroxyvitamin D assays. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.015DOI Listing
March 2019
4 Reads

Oncoxin nutritional supplement in the management of chemotherapy- and/or radiotherapy-associated oral mucositis.

Mol Clin Oncol 2019 Apr 14;10(4):463-468. Epub 2019 Feb 14.

Khanty-Mansiysk State Medical Academy, 628011 Khanty-Mansiysk, Russia.

Oral mucositis (OM) is a common and potentially dangerous complication of anticancer treatment. Since there are only few therapeutic options for OM, there is a need to identify novel approaches to its management and prevention. The aim of the present study was to evaluate the efficacy of Oncoxin (ONCX), a nutritional supplement that contains microelements, vitamins, amino acids and certain biologically active substances of natural origin, in cancer patients who receive chemotherapy, radiotherapy or a combination of the two. Read More

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http://dx.doi.org/10.3892/mco.2019.1809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425507PMC
April 2019
2 Reads

Report from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points.

Arch Toxicol 2019 Mar 30. Epub 2019 Mar 30.

German Federal Institute for Risk Assessment, Berlin, Germany.

This publication summarizes discussions that were held during an international expert hearing organized by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany, in October 2017. The expert hearing was dedicated to providing practical guidance for the measurement of circulating hormones in regulatory toxicology studies. Adequate measurements of circulating hormones have become more important given the regulatory requirement to assess the potential for endocrine disrupting properties for all substances covered by the plant protection products and biocidal products regulations in the European Union (EU). Read More

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http://dx.doi.org/10.1007/s00204-019-02436-3DOI Listing
March 2019
2 Reads

Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.

Free Radic Biol Med 2019 Mar 26;136:12-21. Epub 2019 Mar 26.

Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI, 02912, USA. Electronic address:

Bleomycin is a redox-active drug with anticancer and other clinical applications. It is also frequently used as a tool in fundamental research on cellular responses to DNA double-strand breaks (DSBs). A conversion of bleomycin into its DNA-breaking form requires Fe, one-electron donors and O. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.026DOI Listing
March 2019
1 Read

Vitamin D Usage Among Iranian Population: A Toxicity Crisis is on the Way.

Oman Med J 2019 Mar;34(2):174-175

Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.5001/omj.2019.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425062PMC
March 2019
2 Reads

Vitamin D Usage Among Iranian Population: A Toxicity Crisis is on the Way.

Oman Med J 2019 Mar;34(2):174-175

Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.5001/omj.2019.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425057PMC
March 2019
2 Reads

Does affinity of Cisplatin to B-Vitamins impair the therapeutic effect in the case of patient with lung cancer consuming carrot or beet juice?

Anticancer Agents Med Chem 2019 Mar 25. Epub 2019 Mar 25.

Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpińskiego 5, 85-096, Bydgoszcz. Poland.

Background: Cisplatin (CisPt) has a well-recognized anticancer activity by interacting with DNA and inducing programmed cell death. However, theoretical studies performed on the molecular level suggest that such nonspecific interactions can also take place with many competitive compounds, such as vitamins containing aromatic rings with lone-pair orbitals. It is argued that such direct analogy to interaction of canonical purines can impair the therapeutic effect of Cisplatin. Read More

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http://dx.doi.org/10.2174/1871520619666190325150624DOI Listing
March 2019
1 Read

Comparison and Evaluation of Different Seed Extracts of for Immunomodulatory Effect on Cell-Mediated Immunity through Delayed-Type Hypersensitivity Assay Skin Thickness Method.

J Pharm Bioallied Sci 2019 Jan-Mar;11(1):43-48

Department of Pharmacy, Faculty of Pharmacy, University of Lahore, Lahore, Punjab, Pakistan.

Objective: The aim and objective of this study was to find the immunostimulant and immunomodulatory effect of seed extracts.

Methods: Seeds of were extracted using three different solvents -hexane, chloroform, and methanol by using soxhlet apparatus. To assess the immunomodulatory effect, delayed-type hypersensitivity (DTH) assay method was used and by the DTH assay, the effect of on the skin thickness of rats was estimated. Read More

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http://dx.doi.org/10.4103/jpbs.JPBS_174_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394156PMC
March 2019
1 Read

2-O-β-d-glucopyranosyl--ascorbic acid, a novel vitamin C derivative from Lycium barbarum, prevents oxidative stress.

Redox Biol 2019 Mar 18;24:101173. Epub 2019 Mar 18.

Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China. Electronic address:

Reducing agents are crucial for the management of maladaptive inflammation-induced macrophage death and hematopoietic toxicity of chemotherapy. 2-O-β-d-glucopyranosyl--ascorbic acid (AA-2βG), a unique AA (or vitamin C) derivative identified in Lycium barbarum, exhibited enhanced free radical scavenging activity compared with AA and its synthetic derivative AA-2αG. AA-2βG protected hydrogen peroxide-induced cell death in murine macrophage RAW264. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430735PMC
March 2019
1 Read

Vitamin B combination reduces fluconazole toxicity in Wistar rats.

Daru 2019 Mar 22. Epub 2019 Mar 22.

Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. Box: 80200, Zip Code: 21589, Jeddah, Kingdom of Saudi Arabia.

Background: The major adverse effect associated with systemic administration of Fluconazole (FLZ), is hepatic toxicity. FLZ is most commonly used antifungal drug in treatment of invasive fungal infections.

Methods: FLZ toxicity was challenged by individual and in combination of three vitamins (B1, B2 B3). Read More

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http://dx.doi.org/10.1007/s40199-019-00252-9DOI Listing
March 2019
3 Reads

Adult Idiopathic Renal Fanconi Syndrome: A Case Report.

Electrolyte Blood Press 2018 Dec 31;16(2):19-22. Epub 2018 Dec 31.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Renal Fanconi syndrome (RFS) is caused by generalized proximal tubular dysfunction and can be divided into hereditary and acquired form. Adult-onset RFS is usually associated with drug toxicity or systemic disorders, and modern molecular genetics may explain the etiology of previous idiopathic cases of RFS. Here, we report the case of a 52-year-old woman with RFS whose etiology could not be identified. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5049/EBP.2018.16
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http://dx.doi.org/10.5049/EBP.2018.16.2.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414315PMC
December 2018
3 Reads

Mediators in Preterm Infants With Late-onset Sepsis: A Randomized Controlled Trial.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):578-584

Department of Neonatology, Cleveland Clinic Children's Hospital, Cleveland, OH.

Objective: To evaluate biochemical and clinical effects of 2 different doses of vitamin D supplementation in preterm infants with late-onset sepsis (LOS).

Study Design: A double blinded randomized controlled stratified trial included preterm infants with gestational age (GA) ≥28 weeks with LOS. Subjects were randomly assigned to receive 400 or 800 IU/day of vitamin D3. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002238DOI Listing
April 2019
3 Reads
2.625 Impact Factor

Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity.

Mini Rev Med Chem 2019 Mar 20. Epub 2019 Mar 20.

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. Malaysia.

Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Read More

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http://dx.doi.org/10.2174/1389557519666190320124438DOI Listing
March 2019
4 Reads

Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows.

Exp Biol Med (Maywood) 2019 Mar 19:1535370219838785. Epub 2019 Mar 19.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

Impact Statement: Vitamin A (VA) deficiency and hypervitaminosis A have been reported in groups of people worldwide. Conventional biomarkers of VA deficiency (e.g. Read More

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http://dx.doi.org/10.1177/1535370219838785DOI Listing
March 2019
3 Reads

Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside.

Subcell Biochem 2019;91:435-451

Edward A. Doisy Department of Biochemistry and Molecular Biology, Doisy Research Center, St Louis University School of Medicine, St. Louis, MO, USA.

The structural nuclear proteins known as "lamins" (A-type and B-type) provide a scaffold for the compartmentalization of genome function that is important to maintain genome stability. Mutations in the LMNA gene -encoding for A-type lamins- are associated with over a dozen of degenerative disorders termed laminopathies, which include muscular dystrophies, lipodystrophies, neuropathies, and premature ageing diseases such as Hutchinson Gilford Progeria Syndrome (HGPS). This devastating disease is caused by the expression of a truncated lamin A protein named "progerin". Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_15DOI Listing
January 2019
1 Read

Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats.

Mol Biol Rep 2019 Mar 18. Epub 2019 Mar 18.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.

The increasing application of titanium dioxide nanoparticles (NTiO) in life and the toxicity potential of these nanoparticles have raised concerns about their detrimental effects on human health. This study was conducted to investigate the hepatoprotective effects of vitamin E and vitamin A against hepatotoxicity induced by NTiO in rats. Thirty-six male Wistar rats were randomly divided into six groups of six rats each. Read More

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http://link.springer.com/10.1007/s11033-019-04752-4
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http://dx.doi.org/10.1007/s11033-019-04752-4DOI Listing
March 2019
8 Reads

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.

Mol Carcinog 2019 Mar 18. Epub 2019 Mar 18.

Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity and the acquired resistance by cancer cells. Therefore, synthetic retinoids were developed, such as the atypical adamantyl retinoid ST1926 that provides enhanced bioavailability and reduced toxicity. Read More

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http://dx.doi.org/10.1002/mc.23004DOI Listing
March 2019
1 Read

Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats.

Drug Chem Toxicol 2019 Mar 18:1-8. Epub 2019 Mar 18.

b Institute for Biological Research "Siniša Stanković" , University of Belgrade , Belgrade , Republic of Serbia.

Acetaminophen is widely used as an over-the-counter analgesic and antipyretic drug. The aim of the present study was to investigate the pro-oxidative effects of acetaminophen (300 mg/kg/day i.p. Read More

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http://dx.doi.org/10.1080/01480545.2019.1587451DOI Listing
March 2019
2 Reads

In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform.

Sci Rep 2019 Mar 15;9(1):4616. Epub 2019 Mar 15.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany.

Organ-on-chip platforms provide models that allow the representation of human physiological processes in cell-based miniaturized systems. Potential pre-clinical applications include drug testing and toxicity studies. Here we describe the use of a multi-compartment micro-fluidic chip to recapitulate hepatic vitamin D metabolism (vitamin D to 25-hydroxyvitamin D) and renal bio-activation (25-hydroxyvitamin D to 1,25-dihydroxyvitamin D) in humans. Read More

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http://dx.doi.org/10.1038/s41598-019-40851-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420623PMC
March 2019
1 Read

D-α-tocopherol polyethylene glycol 1000 succinate-modified liposomes with an siRNA corona confer enhanced cellular uptake and targeted delivery of doxorubicin via tumor priming.

Int J Nanomedicine 2019 18;14:1255-1268. Epub 2019 Feb 18.

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China,

Background: Combination therapy employing siRNAs and antitumor drugs is a promising method for the treatment of solid tumors. However, regarding combined treatments involving siRNAs and chemotherapeutic reagents, most prior research has focused on the enhanced cytotoxicity against tumor cells conferred by downregulation of the targeted protein.

Purpose: We developed D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-modified cationic liposomes (LPs) to simultaneously deliver doxorubicin (Dox) and the Bcl-2 siRNA (siBcl-2) for synergistic chemotherapy. Read More

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http://dx.doi.org/10.2147/IJN.S191858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391153PMC
April 2019
1 Read

Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes.

Authors:
Wolfgang Maret

Met Ions Life Sci 2019 Jan;19

After 40 years of significant work, it was generally accepted that chromium in its trivalent valence state, Cr(III), is an essential micronutrient for humans. This view began to be challenged around the turn of the millennium. Some investigators argue that its effects on glucose and lipid metabolism reflect a pharmacological rather than a nutritional mode of action while yet others express concern about the toxicity and safety of supplemental chromium. Read More

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http://dx.doi.org/10.1515/9783110527872-015DOI Listing
January 2019
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The protective role of ascorbic acid in the hepatotoxicity of cadmium and mercury in rabbits.

Environ Sci Pollut Res Int 2019 Mar 9. Epub 2019 Mar 9.

Department of Zoology, University of the Punjab, Lahore, Pakistan.

The liver is one of the vital and sensitive organs which are usually exposed against the toxicity of mercury (Hg) and cadmium (Cd). The main objective of the current study was to evaluate the potential toxicological effects of both Cd and Hg as individual and combined. Hepatotoxicity was evaluated by monitoring the biochemical parameters of the liver and their accumulation in the liver as well as therapeutic role of vitamin C in said toxicity in rabbits (Oryctolagus cuniculus). Read More

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http://link.springer.com/10.1007/s11356-019-04620-5
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http://dx.doi.org/10.1007/s11356-019-04620-5DOI Listing
March 2019
2 Reads
2.828 Impact Factor

Modulatory Role of Vitamins A and E on Memory and Motor Functions of Cyanide Induced Neurotoxicity in Adult Swiss Mice.

Niger J Physiol Sci 2018 Dec 30;33(2):183-189. Epub 2018 Dec 30.

Department of Nursing, College of Nursing and Midwifery Sciences, Sokoto.

Cyanide is a potent neurotoxic substance that can initiate series of intracellular reactions leading to oxidativestress. To evaluate effect of sublethal administration of potassium cyanide (KCN) on sensorimotor functions and long termvisuo-spatial learning and memory in adult Swiss mice and possible ameliorative role of vitamins A and E. These vitaminsA and E (dietary) are antioxidants that have scavenging properties against free radicals and reactive oxygen species as aresult of oxidative stress induced by cyanide. Read More

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December 2018
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Timing of folic acid/vitamin B12 supplementation and hematologic toxicity during first-line treatment of patients with nonsquamous non-small cell lung cancer using pemetrexed-based chemotherapy: The PEMVITASTART randomized trial.

Cancer 2019 Mar 2. Epub 2019 Mar 2.

Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Vitamin B12 and folic acid (FA) supplementation (B12-FAS) reduces hematologic toxicity with pemetrexed-based chemotherapy (PEM). However, the basis for recommending 1 week of B12-FAS before PEM initiation has never been proven in a randomized trial.

Methods: An open-label, randomized trial (PEMVITASTART; clinicaltrials. Read More

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http://dx.doi.org/10.1002/cncr.32028DOI Listing
March 2019
3 Reads
4.889 Impact Factor

Cardiovascular Effects of PCB 126 (3,3',4,4',5-Pentachlorobiphenyl) in Zebrafish Embryos and Impact of Co-Exposure to Redox Modulating Chemicals.

Int J Mol Sci 2019 Mar 1;20(5). Epub 2019 Mar 1.

GRET-Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.

The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we exposed zebrafish embryos to PCB126 or to several redox-modulating chemicals to study their ability to modulate the dysmorphogenesis produced by PCB126. Read More

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http://dx.doi.org/10.3390/ijms20051065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429282PMC
March 2019
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Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy).

Case Rep Endocrinol 2019 20;2019:1482727. Epub 2019 Jan 20.

University of Oklahoma College of Pharmacy, Pediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4502 E. 41 St, Tulsa, OK 74135, 918-660-3578, USA.

Globally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. Read More

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http://dx.doi.org/10.1155/2019/1482727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360572PMC
January 2019
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Nephroprotective and antioxidant effect of green tea (Camellia sinensis) against nicotine-induced nephrotoxicity in rats and characterization of its bioactive compounds by HPLC-DAD.

Appl Physiol Nutr Metab 2019 Feb 25. Epub 2019 Feb 25.

3Higher Institute of Applied Biology ISBAM Medenine 4119, University of Gabes, Tunisia., Gafsa, None Selected, Tunisia ;

Nicotine (NT) is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. Natural antioxidants that prevent or slow the progression and severity of nicotine toxicity may have a significant health impact. The purpose of this study, conducted on Wistar rats, was to evaluate the beneficial effects of green tea (Camellia sinensis) extract on nicotine treatment induced damage on kidney. Read More

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http://www.nrcresearchpress.com/doi/10.1139/apnm-2017-0834
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http://dx.doi.org/10.1139/apnm-2017-0834DOI Listing
February 2019
2 Reads

Interaction of aminophylline with photoilluminated riboflavin leads to ROS mediated macromolecular damage and cell death in benzopyrene induced mice lung carcinoma.

Chem Biol Interact 2019 Apr 15;302:135-142. Epub 2019 Feb 15.

Department of Biochemistry, Faculty of Life Sciences, AMU, India. Electronic address:

Riboflavin (Rf) or vitamin B₂ is a known photosensitizer whose photophysical and photochemical properties are well established. Aminophylline (Am) is a phosphodiesterase inhibitor and is currently used as a bronchodilator. Although there are several reports of haemolytic and proteolytic interaction of photoilluminated riboflavin with aminophylline, the cytotoxicity of this system against malignant tissue is not well defined and fully unravelled. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.003DOI Listing
April 2019
2 Reads

Boron supply maintains efficient antioxidant system, cell wall components and reduces aluminum concentration in roots of trifoliate orange.

Plant Physiol Biochem 2019 Apr 8;137:93-101. Epub 2019 Feb 8.

Microelement Research Center, College of Resources and Environment, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China. Electronic address:

Aluminum (Al) toxicity in the acid soils (pH ≤ 5) is the major limiting abiotic factor affecting the productivity of crops. Boron (B) has been reported to alleviate Al toxicity. In spite of recent advances, it is not clear how B relieves Al toxicity. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.02.003DOI Listing
April 2019
3 Reads
2.756 Impact Factor

Bilateral Medullary Nephrocalcinosis Secondary to Vitamin D Toxicity: A 14-year Follow-up Report.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):853-854

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ijem.IJEM_588_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330868PMC
February 2019
2 Reads

Chlorpyrifos stimulates expression of vitamin D receptor in skin cells irradiated with UVB.

Pestic Biochem Physiol 2019 Feb 12;154:17-22. Epub 2018 Dec 12.

Institute of Rural Health, Department of Molecular Biology and Translational Research, Lublin, Poland; University of Information Technology and Management, Department of Medical Biology and Translational Research, Rzeszow, Poland. Electronic address:

Skin, the organ responsible for vitamin D synthesis, is fully exposed to many xenobiotics, e.g. polycyclic aromatic hydrocarbons and pesticides. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00483575183052
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http://dx.doi.org/10.1016/j.pestbp.2018.12.003DOI Listing
February 2019
4 Reads

The clinical presentation of cobalamin-related disorders: From acquired deficiencies to inborn errors of absorption and intracellular pathways.

J Inherit Metab Dis 2018 Dec 27. Epub 2018 Dec 27.

Division of Metabolism and Children's Research Center, University Children's Hospital Zürich, Zürich, Switzerland.

This review gives an overview of clinical characteristics, treatment and outcome of nutritional and acquired cobalamin (Cbl; synonym: vitamin B12) deficiencies, inborn errors of Cbl absorption and intracellular trafficking, as well as methylenetetrahydrofolate dehydrogenase (MTHFD1) and methylene tetrahydrofolate reductase (MTHFR) deficiencies, which impair Cbl-dependent remethylation. Acquired and inborn Cbl-related disorders and MTHFR deficiency cause multisystem, often severe disease. Failure to thrive, neurocognitive or psychiatric symptoms, eye disease, bone marrow alterations, microangiopathy and thromboembolic events are characteristic. Read More

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http://dx.doi.org/10.1002/jimd.12012DOI Listing
December 2018
2 Reads