21,689 results match your criteria Toxicity Vitamin

Ethyl acetate fraction of () attenuates lead acetate induced testicular toxicity in male Wistar rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Benjamin S. Carson (Snr.) School of Medicine, Babcock University, Ilishan-Remo, Ogun State, Nigeria.

Objectives: The use of in folklore medicine for the management of reproductive disorders has been poorly reported. We sought to investigate the protective potential of the ethyl acetate fraction of stem bark extract (EFSC) on lead acetate-induced (LA) testicular toxicity in male rats.

Methods: Animals during a 28 days treatment received dimethyl sulfoxide (DMSO, 0. Read More

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Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future.

Curr Dev Nutr 2021 May 25;5(5):nzab018. Epub 2021 Feb 25.

Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC, USA.

The risk of vitamin D insufficiency in humans is a global problem that requires improving ways to increase vitamin D intake. Supplements are a primary means for increasing vitamin D intake, but without a clear consensus on what constitutes vitamin D sufficiency, there is toxicity risk with taking supplements. Chickens have been used in many vitamin-D-related research studies, especially studies involving vitamin D supplementation. Read More

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[Management of patients developing acute gastro-intestinal graft-versus-host-disease: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2021 May 6. Epub 2021 May 6.

Université de Lille, CHU de Lille, Inserm U1286, Infinite, 59000 Lille, France.

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic cell transplantation (allo-HCT) with a frequency range of 30% to 50%. GVH is the leading cause of non-relapse-related deaths and a cause early mortality. Gastro-intestinal (GI) GVH results in digestive manifestations that involve the small intestine and the colon. Read More

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Efficacy of vitamin E in protection against methotrexate induced placental injury in albino rats.

Biomed Pharmacother 2021 May 6;139:111637. Epub 2021 May 6.

Anatomy Department, Faculty of Medicine, Minia University, Egypt. Electronic address:

Methotrexate (MXT) is a chemotherapeutic drug that has been used in a wide range of clinical practices. Unfortunately, the administration of MXT during pregnancy may induce abortion, fetal deformities, and intrauterine growth retardation. Vitamin E is an antioxidant agent that can ameliorate free radical damage. Read More

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Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride.

Sci Total Environ 2021 Apr 30;786:147434. Epub 2021 Apr 30.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

Sertraline hydrochloride (Ser-HCl) is an effective and commonly used antidepressant drug, which is also frequently detected in aquatic environments. Our previous research showed that Ser-HCl changes the community composition of aquatic microbiome, but the understanding of the expression of functional pathways in microbial communities is still incomplete; to address this knowledge gap, we used meta-transcriptomics analysis to evaluate the toxicity of Ser-HCl to natural aquatic microbial communities cultured in laboratory microcosms. Meta-transcriptomic results show that a 15-day exposure to 50 μg/L Ser-HCl significantly changed the functional expression activity of aquatic microbial communities. Read More

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Central and peripheral pain intervention by Ophiorrhizarugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators.

J Ethnopharmacol 2021 May 5;276:114182. Epub 2021 May 5.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy. Electronic address:

Ethnopharmacological Relevance: Ophiorrhiza rugosa var. prostrata is a traditional medicinal plant used by the indigenous and local tribes (Chakma, Marma and Tanchangya) of Bangladesh for the management of chest pain, body ache, and earache. However, the knowledge of anti-nociceptive and anti-inflammatory potentials of this plant is scarce. Read More

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Protective and therapeutic effects of ethanolic extract of (watercress) and vitamin E against bleomycin-induced pulmonary fibrosis in rats.

Res Pharm Sci 2021 Feb 30;16(1):94-102. Epub 2020 Dec 30.

Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.

Background And Purpose: Pulmonary fibrosis is a chronic disease of the lungs caused by inflammation, species of reactive oxygen, and immune defects. Antioxidant properties of has been reported in some studies. Therefore, the objective of the current study was to evaluate the effect of ethanolic extract of (EENO) on bleomycin (BLM)-induced lung fibrosis in rats. Read More

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February 2021

Complementary and Alternative Medicine for the Treatment of Gliomas: Scoping Review of Clinical Studies, Patient Outcomes, and Toxicity Profiles.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

USC Brain Tumor Center, USC Department of Neurosurgery, Keck School of Medicine of the University of Southern California. Los Angeles, CA, USA.

Introduction: Complementary and alternative medicine (CAM) are highly utilized amongst those diagnosed with glioma. Further research is warranted, however, as it remains important to clearly delineate CAM practices that are unproven, disproven, or promising for future research and implementation.

Methods: A systematic review was conducted to identify all articles that investigated the effect of any CAM therapy on survival of patients with newly diagnosed or recurrent glioma. Read More

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Protective Effect of Combined Long Time Administration of Selenium and Vitamin C on Liver and Kidney Toxicity of Cadmium in Rats.

Iran J Pathol 2021 23;16(2):174-180. Epub 2020 Nov 23.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background & Objective: Increased industrial activities leads to prolonged human exposure to industrial pollutant such as cadmium (Cd). ‍Chronic exposure to Cd in Mammals and also human being, can cause damages to various organs and particularly kidneys and liver. The goal of this study was to investigate the prophylactic effects of combined selenium (Se) and ascorbic acid supplement in rat cadmium toxicity. Read More

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November 2020

Ultraviolet B-irradiated mushroom supplementation increased the Ca uptake and ameliorated the LPS-induced inflammatory responses in zebrafish larvae.

J Food Biochem 2021 Apr 30:e13742. Epub 2021 Apr 30.

Department of Biotechnology, Daegu University, Gyeongsan, Republic of Korea.

The harmful effects of excessive ultraviolet (UV) exposure are well known. However, moderate exposure to UV radiation is beneficial and required for active vitamin D synthesis in our body. People living in the coldest regions on the earth are unable to expose their skin to the solar UV radiation and, therefore, additional supplementation of Vitamin D2 is recommended. Read More

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Melatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation Signaling.

Oxid Med Cell Longev 2021 8;2021:5573357. Epub 2021 Apr 8.

Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Republic of Korea.

Despite the numerous studies on melatonin and nicotinamide (NAM, the active form of vitamin B3), the linkage between these two biomolecules in the context of signaling pathways regulating preimplantation embryo development has not yet been investigated. In this study, we used bovine oocyte model to elucidate the effect of melatonin on the developmental competence of oocytes under the stress of high NAM concentrations. Results showed that NAM (20 mM) administration during in vitro maturation (IVM) significantly reduced oocyte maturation and actin distribution, while induced reactive oxygen species (ROS) accumulation and mitochondrial dysfunction, the multiple deleterious effects that were alleviated by melatonin (10 M). Read More

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Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate.

Antioxidants (Basel) 2021 Apr 16;10(4). Epub 2021 Apr 16.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Pancreatic cancer cells (PDACs) are more susceptible to an oxidative insult than normal cells, resulting in greater cytotoxicity upon exposure to agents that increase pro-oxidant levels. Pharmacological ascorbate (P-AscH), i.e. Read More

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Lichens-A Potential Source for Nanoparticles Fabrication: A Review on Nanoparticles Biosynthesis and Their Prospective Applications.

J Fungi (Basel) 2021 Apr 12;7(4). Epub 2021 Apr 12.

Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11543, Saudi Arabia.

Green synthesis of nanoparticles (NPs) is a safe, eco-friendly, and relatively inexpensive alternative to conventional routes of NPs production. These methods require natural resources such as cyanobacteria, algae, plants, fungi, lichens, and naturally extracted biomolecules such as pigments, vitamins, polysaccharides, proteins, and enzymes to reduce bulk materials (the target metal salts) into a nanoscale product. Synthesis of nanomaterials (NMs) using lichen extracts is a promising eco-friendly, simple, low-cost biological synthesis process. Read More

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Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity.

Adv Nutr 2021 Apr 29. Epub 2021 Apr 29.

University College Venlo, Campus Venlo, Maastricht University, Maastricht, The Netherlands.

Vitamin B-6 in the form of pyridoxine (PN) is commonly used by the general population. The use of PN-containing supplements has gained lots of attention over the past years as they have been related to the development of peripheral neuropathy. In light of this, the number of reported cases of adverse health effects due to the use of vitamin B-6 have increased. Read More

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Assessing the potential use of chitosan scaffolds for the sustained localized delivery of vitamin D.

Saudi J Biol Sci 2021 Apr 20;28(4):2210-2215. Epub 2021 Jan 20.

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Vitamin D is a commonly used bone modulator in regenerative medicine. Several modalities have been explored for the delivery of vitamin D including nanoparticles and scaffold. The present study aimed to assess the potential use of a bio-degradable chitosan scaffold for the delivery of vitamin D. Read More

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Nutrition, one-carbon metabolism and arsenic methylation.

Toxicology 2021 Apr 24;457:152803. Epub 2021 Apr 24.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:

Exposure to arsenic (As) is a major public health concern globally. Inorganic As (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl (DMAs)-arsenical species, facilitating urinary As elimination. MMAs is considerably more toxic than either InAs or DMAs, and a higher proportion of MMAs in urine has been associated with risk for a wide range of adverse health outcomes. Read More

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Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks.

Front Cell Dev Biol 2021 9;9:663032. Epub 2021 Apr 9.

The Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States.

The ubiquitous use of flame retardant chemicals (FRCs) in the manufacture of many consumer products leads to inevitable environmental releases and human exposures. Studying toxic effects of FRCs as a group is challenging since they widely differ in physicochemical properties. We previously used zebrafish as a model to screen 61 representative FRCs and showed that many induced behavioral and teratogenic effects, with aryl phosphates identified as the most active. Read More

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Gender-dependent reproductive toxicity of copper metal-organic frameworks and attenuation by surface modification.

Nanoscale 2021 Apr 13;13(15):7389-7402. Epub 2021 Apr 13.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Metal-organic frameworks (MOFs) as promising materials have been widely used in drug delivery, disease diagnosis and therapy; however, their effects on the reproductive system remain unknown, which hinders their further clinical applications. Here we show that repeated subcutaneous injections of copper MOFs (HKUST-1) induce higher toxicity into the male reproductive system relative to the female reproductive system, with disrupted seminiferous tubule histology, sperm generation disorder, irreversible sperm morphological abnormities and reduced pregnancy rate but only slight follicle dysfunction and pregnancy complications in female mice. Interestingly, the modification of HKUST-1 with folic acid attenuates the reproductive toxicity and even improves pregnancy and fetus development. Read More

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In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles.

Int J Nanomedicine 2021 15;16:2879-2896. Epub 2021 Apr 15.

The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.

Background: Effective treatment strategy for cervical carcinoma is subject to the limitation of its anatomical location and histological characteristics. Comprehensive imaging before cervical carcinoma treatment is of great significance for the patients. Current imaging methods cannot meet the requirements of high resolution, deep imaging depth and non-invasive imaging at the same time. Read More

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Arrabidaea chica Verlot fractions reduce MIA-induced osteoarthritis progression in rat knees.

Inflammopharmacology 2021 Apr 21. Epub 2021 Apr 21.

Biological and Health Sciences Center, Federal University of Maranhão, Av. dos Portugueses 1966, São Luís, MA, 65085-580, Brazil.

This study aims to investigate the activity of n-hexane, ethyl acetate and butanol fractions obtained from Arrabidaea chica Verlot against MIA-induced osteoarthritis (OA). The antinociceptive potentials of each fraction were evaluated through a cyclooxygenase (COX) 1 and 2 inhibition test and an in vivo OA-model. In addition, toxicity assessments in the liver, spleen and kidney, as well as radiographic and histopathological knee analyses, were performed. Read More

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Stoss therapy is safe for treatment of vitamin D deficiency in pediatric patients undergoing HSCT.

Bone Marrow Transplant 2021 Apr 19. Epub 2021 Apr 19.

Phoenix Children's Hospital, Phoenix, AZ, USA.

Vitamin D deficiency remains common among pediatric patients undergoing hematopoietic stem cell transplant (HSCT) despite both aggressive and standard of care strategies. This study examined the safety and efficacy of single high-dose oral vitamin D therapy (Stoss therapy) for treatment of vitamin D deficiency in HSCT recipients. Patients ages 1-21 years presenting for HSCT were randomized to receive either Stoss regimen plus weekly/daily supplementation or standard of care, per US Endocrine Society guidelines. Read More

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Polyethyleneimine- -Tocopherol Hydrogen Succinate/Hyaluronic Acid-Quercetin (PEI-TOS/HA-QU) Core-Shell Micelles Delivering Paclitaxel for Combinatorial Treatment of MDR Breast Cancer.

J Biomed Nanotechnol 2021 Mar;17(3):382-398

Multidrug resistance (MDR) remains a significant impediment to chemotherapy during cancer therapy. In this study, the amphiphilic biomaterials PEI-TOS and HA-QU were synthesized to self-assemble into PEI-TOS/HA-QU core-shell micelles for the targeted codelivery of paclitaxel (PTX) and quercetin (QU) to alleviate multidrug drug resistance and enhance therapeutic efficacy. The PTX-loaded micelles possessed a uniform particle size (167. Read More

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MRI of Nitrous Oxide-Related Subacute Cervical Myelopathy.

J Belg Soc Radiol 2021 Apr 8;105(1):22. Epub 2021 Apr 8.

AZ Monica, BE.

Myelopathy may occur following nitrous oxide (NO) misuse, even if vitamin B12-levels are normal. The typical appearance on magnetic resonance imaging (MRI), is an inverted V-shaped T2-weighted hypersignal in the dorsal columns of the cervicothoracic spinal cord. Read More

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Ethanol extract of (Gaertn, F) leaves protects against sodium arsenite - induced toxicity in male wistar rats.

Toxicol Rep 2021 2;8:774-784. Epub 2021 Apr 2.

Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

The inadvertent exposure to arsenic has been associated with diverse diseases such as cancers. is a medicinal plant with antidiabetic and antiproliferative properties. Here, we assessed the ameliorative role of Ethanol Leaf extract of (ELVp) in Sodium Arsenite (SA) - induced toxicity in rats after oral treatment for two weeks as follows: Group 1 (Control, distilled water), Group 2 (Vitamin E, 100 mg/kg), Groups 3 and 4 (ELVp, 100 & 200 mg/kg respectively), Group 5 (SA, 2. Read More

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The influence of vitamin D on mammographic density: results from CALGB 70806 (Alliance) a randomized clinical trial.

Cancer Prev Res (Phila) 2021 Apr 13. Epub 2021 Apr 13.

Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center.

Current therapies for breast cancer prevention only prevent estrogen receptor positive (Er+) disease and toxicity limits use of these agents. Vitamin D is a potential prevention therapy for both Er+ and Er- disease and is safe with few side effects. This study evaluates the effect of one-year of vitamin D supplementation on mammographic density (MD), a biomarker of breast cancer risk in a multicenter randomized controlled trial. Read More

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Rare presentation of subglottic soft-tissue swelling following FOLFOX therapy in a patient with metastatic oesophageal cancer.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Critical Care Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA

Oesophageal cancer is categorised among the most fatal cancers across the world with a mortality ranking of sixth position. Chemotherapy with FOLFOX-a regimen of fluorouracil, leucovorin, and oxaliplatin-has been approved in the treatment of oesophageal cancer owing to its lower toxicity compared with the previous regimens. We report the first case of a patient with oesophageal cancer metastatic to the hyoid presenting with sudden-onset shortness of breath and anterior neck swelling secondary to treatment with FOLFOX-6. Read More

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Chlorpyrifos alters expression of enzymes involved in vitamin D synthesis in skin cells.

Pestic Biochem Physiol 2021 May 27;174:104812. Epub 2021 Feb 27.

Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland. Electronic address:

Skin acts as a mechanical barrier between human body and environment. Epidermal cells are regularly exposed to many physiological and environmental stressors, such as pesticides, like chlorpyrifos (CPS). It is recognised that CPS may affect metabolism of other exo- and endogenous substances by affecting enzyme activity and expression. Read More

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Nitrous oxide-induced motor-predominant axonal peripheral neuropathy: A phenotype distinct from isolated vitamin B12 deficiency.

J Neurol Sci 2021 05 11;424:117390. Epub 2021 Mar 11.

Department of Neurology, Atkinson Morley Neurosciences Centre, St George's Hospital, London SW17 0QT, United Kingdom. Electronic address:

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