An Acad Bras Cienc 2021 15;93(2):e20190861. Epub 2021 Mar 15.
Centro de Investigaciones Cerebrales, Universidad Veracruzana, Médicos y Odontólogos, s/n, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, México.
Autism spectrum disorder is associated with alterations in GABAergic and glutamatergic neurotransmission. Here, we aimed to determine the concentration of GABA, glutamate, glutamine, aspartate, taurine, and glycine in brain tissue and plasma of rats prenatally exposed to valproic acid (VPA), a well-characterized experimental model of autism. Pregnant rats were injected with VPA (600mg/Kg) during the twelfth-embryonic-day. Read More