Int J Biol Macromol 2022 Jun 7;210:252-260. Epub 2022 May 7.
Nanobiotechnology Department, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran; Biophysics Department, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran. Electronic address:
Valproic acid (VPA) usage in high dose is teratogen with low bioavailability. Hence to improve its efficacy and reduce its side effect it was encapsulated by the Nano liposomes and stabilized by the chitosan at different concentrations. The cellular uptake, biocompatibility, loading and encapsulation efficiency of the six-different formulations (1:1, 2:1, and 4:1 of chitosan-phospholipids: VPA), PC12 differentiation to neuron cells assays (gene-expression level by qRT-PCR) were conducted for the efficacy assessment of the Nano carriers. Read More