2,851 results match your criteria Toxicity Toluene


In vitro toxicological evaluation of emissions from catalytic oxidation removal of industrial VOCs by air/liquid interface (ALI) exposure system in repeated mode.

Toxicol In Vitro 2019 Mar 22;58:110-117. Epub 2019 Mar 22.

UCEIV - EA4492, Unité de Chimie Environnementale et Interactions sur le Vivant, SFR Condorcet FR CNRS 3417, Université du Littoral Côte d'Opale, Dunkerque, France.

Toxicity of toluene and by-products formed during its catalytic oxidative degradation was studied in human bronchial BEAS-2B cells repeatedly exposed. BEAS-2B cells were exposed using an Air-Liquid Interface (ALI) System (Vitrocell®) for 1 h per day during 1, 3 or 5 days to gaseous flows: toluene vapors (100 and 1000 ppm) and outflow after catalytic oxidation of toluene (10 and 100%). After exposure to gaseous flow, cytotoxicity, inflammatory response and Xenobiotic Metabolism Enzymes (XME) gene expression were investigated. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.03.030DOI Listing
March 2019
2 Reads

Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.

Biotech Histochem 2019 Mar 1:1-6. Epub 2019 Mar 1.

g School of Medicine, Department of Physiology , Bezmialem Vakif University , Istanbul , Turkey.

Toluene is an organic solvent that is toxic to humans. Caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ) exhibit antioxidant and antitoxic effects. We investigated the protective effects of CAPE and TQ on toluene induced hepatotoxicity. Read More

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http://dx.doi.org/10.1080/10520295.2018.1554825DOI Listing
March 2019
1 Read

Copper promotes E. coli laccase-mediated TNT biotransformation and alters the toxicity of TNT metabolites toward Tigriopus japonicus.

Ecotoxicol Environ Saf 2019 May 21;173:452-460. Epub 2019 Feb 21.

Department of Biotechnology, National Kaohsiung Normal University, Kaohsiung, Taiwan. Electronic address:

Although laccase is involved in the biotransformation of 2,4,6-trinitrotoluene (TNT), little is known regarding the effect of E. coli laccase on TNT biotransformation. In this study, E. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.056DOI Listing
May 2019
3 Reads

Environmental Aspects of the Use of Extract in Bioremediation Process.

Microorganisms 2019 Feb 5;7(2). Epub 2019 Feb 5.

Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland.

This paper analyzes the impact of saponins from English ivy leaves on the properties of environmental bacterial strains and hydrocarbon degradation ability. For this purpose, two bacterial strains, M03 and M1B, have been used in toluene, 4-chlorotoluene, and α,α,α-trifluorotoluene biodegradation supported by extract. Moreover, theeffects of ivy exposition on cell properties and extract toxicity were investigated. Read More

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http://www.mdpi.com/2076-2607/7/2/43
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http://dx.doi.org/10.3390/microorganisms7020043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406833PMC
February 2019
2 Reads

Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor.

Sci Total Environ 2019 Feb 5;653:1140-1148. Epub 2018 Nov 5.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

Acetochlor (ACT) is a chiral chloroacetamide pesticide that has been heavily used around the world, resulting in its residues being frequently found in surface waters. It has been reported that ACT is an endocrine disrupting chemical (EDC) with strong thyroid hormone-disrupting activity in aquatic organisms. However, the enantioselectivity underlying thyroid disruption has yet to be understood. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.037DOI Listing
February 2019
2 Reads

A case study of BTEX characteristics and health effects by major point sources of pollution during winter in Iran.

Environ Pollut 2019 Apr 24;247:607-617. Epub 2019 Jan 24.

Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This study characterized spatio-temporal variations in the concentration of benzene, toluene, ethylbenzene, and xylene (BTEX) compounds in the vicinity of gas and compressed natural gas (CNG) stations in Tehran, Iran. Health risk assessment (HRA) was computed using Monte Carlo simulations (MCS) for evaluating inhalation lifetime cancer risk (LTCR), the hazard quotient (HQ), and sensitivity analysis (SA) for BTEX exposure in different age groups (birth to <81) and as a function of distance (0-250 m) from the center of the stations. For all monitoring stations, the average values of benzene, toluene, ethylbenzene, and xylene in winter were 466. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.070DOI Listing
April 2019
1 Read

Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures.

Forensic Toxicol 2019 Jan 28;37(1):17-26. Epub 2018 Jun 28.

RTI International, 3040 Cornwallis Road, Research Triangle Park, NC, 27709, USA.

Purpose: The use of novel synthetic cannabinoids as intoxicants continues in spite of associated health risks. These compounds are typically smoked or vaporized, but many synthetic cannabinoids contain thermally labile chemical moieties. This study investigated the thermal stability six carboxamide-type synthetic cannabinoids (CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18) in order to characterise potential user exposure to thermolysis products. Read More

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http://dx.doi.org/10.1007/s11419-018-0430-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349387PMC
January 2019
3 Reads

[Study on proteomic profiling changes of workers exposed to methylbenzene and healthy individuals].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):824-826

Wuxi Rehabilitation Hospital, Wuxi 214043, China.

This study focused on the proteomicchanges between workers exposed to methylbenzene (WMB) and healthy individuals (HI) . The serum of WMB and HI was collected and the unmarked label free mass spectrometry was utilized for protein identification and quantitative comparison. The differentlyexpressed proteins in WMB and the HI were screened, followed by the analysis of protein and biological functions by bioinformatics tools. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.006DOI Listing
November 2018
1 Read

Amitraz toxicity to the midge Chironomus riparius: Life-history and biochemical responses.

Chemosphere 2019 Apr 4;221:324-332. Epub 2019 Jan 4.

Departamento de Biologia & CESAM, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.

Acute and chronic toxicity of the formamidine pesticide amitraz to the midge Chironomus riparius was assessed using conventional ecotoxicological tests and biochemical approaches (biomarkers). Amitraz is mainly used as an ectoparasiticide in veterinary medicine, but also in agriculture and apiculture. However, information of amitraz toxicity to non-target invertebrates is limited. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.018DOI Listing
April 2019
3 Reads

Enantiomeric environmental behavior, oxidative stress and toxin release of harmful cyanobacteria Microcystis aeruginosa in response to napropamide and acetochlor.

Environ Pollut 2019 Mar 18;246:728-733. Epub 2018 Dec 18.

MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Harmful algal blooms have emerged as a worldwide issue. After concentrations of herbicides entering water, herbicides in water may pose ecological effects on them. The present study investigates the toxicity and environmental behavior of the herbicides, napropamide and acetochlor as enantiomers and as racemates on Microcystis aeruginosa which is the main specie known to produce hepatotoxins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183475
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http://dx.doi.org/10.1016/j.envpol.2018.12.056DOI Listing
March 2019
11 Reads

Assessment of benzene, toluene, ethyl-benzene, and xylene (BTEX) toxicity in soil using sulfur-oxidizing bacterial (SOB) bioassay.

Chemosphere 2019 Apr 17;220:651-657. Epub 2018 Dec 17.

Department of Biological Environment, Kangwon National University, Chuncheon, 24341, Gangwon-do, South Korea. Electronic address:

The assessment of benzene, toluene, ethyl-benzene, and xylene (BTEX)-contaminated soil toxicity was performed using a sulfur-oxidizing bacteria (SOB) assay. The experiments were set up using an individual pollutant in a 25-mL bottle sealed with a rubber stopper and aluminum cap since BTEX are volatile. A large headspace volume (14 mL) was kept in the reactors to provide enough oxygen for the SOB. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.102DOI Listing
April 2019
3 Reads

Toxicity and expression of oxidative stress genes in Tribolium castaneum induced by toluene, xylene, and thinner.

J Toxicol Environ Health A 2019 24;82(1):28-36. Epub 2018 Dec 24.

a Environmental and Computational Chemistry Group. School of Pharmaceutical Sciences , Zaragocilla Campus. University of Cartagena , Cartagena, Bolivar , Colombia.

Thinner is a solvent that contains toluene, xylene, and other substances. The aim of this study was to examine the toxicity of thinner, xylene, and toluene on adult red flour beetles, Tribolium castaneum (Herbst), as well as the effects of thinner and toluene on gene expression. The major compounds identified in the thinner with peak area >2% were p-xylene (6%), toluene (4%), 2,4-dimethylheptane (3%), methylcyclohexane (2. Read More

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https://www.tandfonline.com/doi/full/10.1080/15287394.2018.1
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http://dx.doi.org/10.1080/15287394.2018.1546245DOI Listing
December 2018
13 Reads

Pulsed laser assisted synthesis of gadolinium carbide/carbon shell dots with enhanced magnetic resonance properties.

Nanotechnology 2019 Mar 6;30(10):105705. Epub 2018 Dec 6.

School of Materials Science and Engineering, Hefei University of Technology, Anhui 230009, People's Republic of China. State Key Laboratory of Pulsed Power Laser Technology, Electronic Engineering Institute, Anhui 230037, People's Republic of China.

There is now the opportunity for nanomaterials to be utilized in bioapplications with low toxicity, good stability and fine dissolvability. Herein, we present a pulsed laser assisted carbon coating method for nanocrystals, and gadolinium carbide/carbon shell (GC/CS) dots with a face-centered cubic structured gadolinium carbide core that have been synthesized in toluene. Good stability of the GC/CS dots was observed, not only in ethanol but also in the immunoconjugates. Read More

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http://iopscience.iop.org/article/10.1088/1361-6528/aaf6c5
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http://dx.doi.org/10.1088/1361-6528/aaf6c5DOI Listing
March 2019
12 Reads

Successful resuscitation of prolonged cardiac arrest occurring in association with '' and toluene toxicity.

Turk J Emerg Med 2018 Dec 7;18(4):172-175. Epub 2018 Mar 7.

Karadeniz Technical University, Faculty of Medicine, Department of Cardiology, Trabzon, Turkey.

We report a case of prolonged and successful resuscitation following cardiotoxicity-related arrest occurring after inhaling toluene and , which is an increasingly popular synthetic cannabinoid (SC). Following presentation to the emergency department because of lethargy, nausea and chest pain, a 28-year-old male user of and toluene suffered from cardiac arrest due to ventricular fibrillation (VF). Cardiogenic shock, severe metabolic acidosis and regular wide QRS tachycardia were observed in the patient, and he developed VF every 5-10 minutes over the course of 10 hours. Read More

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http://dx.doi.org/10.1016/j.tjem.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261096PMC
December 2018
4 Reads

Multiple environmental stressors induce complex transcriptomic responses indicative of phenotypic outcomes in Western fence lizard.

BMC Genomics 2018 Dec 5;19(1):877. Epub 2018 Dec 5.

U.S. Army Public Health Center, Aberdeen Proving Ground, Aberdeen, MD, 21010, USA.

Background: The health and resilience of species in natural environments is increasingly challenged by complex anthropogenic stressor combinations including climate change, habitat encroachment, and chemical contamination. To better understand impacts of these stressors we examined the individual- and combined-stressor impacts of malaria infection, food limitation, and 2,4,6-trinitrotoluene (TNT) exposures on gene expression in livers of Western fence lizards (WFL, Sceloporus occidentalis) using custom WFL transcriptome-based microarrays.

Results: Computational analysis including annotation enrichment and correlation analysis identified putative functional mechanisms linking transcript expression and toxicological phenotypes. Read More

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-018-5270-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282355PMC
December 2018
16 Reads

Pharmacokinetics and brain distribution of amitraz and its metabolites in rats.

Environ Toxicol Pharmacol 2019 Jan 23;65:40-45. Epub 2018 Nov 23.

Zoetis, Inc., Veterinary Medicine Research and Development, Kalamazoo, MI, 49007, USA.

Amitraz is an acaricide and insecticide widely used in agriculture and veterinary medicine. Although central nervous system (CNS) toxicity is one of major toxicities following oral ingestion of amitraz, the understanding of the cause of the toxicity is limited. This study evaluated the systemic and brain exposure of amitraz and its major metabolites, BTS27271, 2',4'-formoxylidide, and 2,4-dimethylaniline following administration of amitraz in male Sprague-Dawley rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183047
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http://dx.doi.org/10.1016/j.etap.2018.11.005DOI Listing
January 2019
3 Reads

Genetic modification of western wheatgrass (Pascopyrum smithii) for the phytoremediation of RDX and TNT.

Planta 2019 Apr 28;249(4):1007-1015. Epub 2018 Nov 28.

Department of Civil and Environmental Engineering, University of Washington, Box 355014, Seattle, WA, 98195-5014, USA.

Main Conclusion: Transgenic western wheatgrass degrades the explosive RDX and detoxifies TNT. Contamination, from the explosives, hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine (RDX), and 2, 4, 6-trinitrotoluene (TNT), especially on live-fire training ranges, threatens environmental and human health. Phytoremediation is an approach that could be used to clean-up explosive pollution, but it is hindered by inherently low in planta RDX degradation rates, and the high phytotoxicity of TNT. Read More

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http://link.springer.com/10.1007/s00425-018-3057-9
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http://dx.doi.org/10.1007/s00425-018-3057-9DOI Listing
April 2019
6 Reads

Analysis of bacteria stress responses to contaminants derived from shale energy extraction.

Environ Sci Process Impacts 2019 Feb;21(2):269-278

Department of Chemistry and Biochemistry, The University of Texas at Arlington, 700 Planetarium Pl.; Box 19065, Arlington, TX 76019-0065, USA.

In order to survive environmental changes, bacteria have stress responses, which protect them from adverse and variable conditions. Contamination can be a source of stress and bacterial responses can serve as an indicator of environmental abnormality. In this work, the biochemical effects of toxic compounds that stem from hydraulic fracturing were measured on the whole cell-derived fatty acid and protein compositions of Escherichia coli, Klebsiella oxytoca, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzeri, Aeromonas hydrophila, Bacillus cereus, and Bacillus subtilis. Read More

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http://xlink.rsc.org/?DOI=C8EM00338F
Publisher Site
http://dx.doi.org/10.1039/c8em00338fDOI Listing
February 2019
16 Reads

Evaluation of Three Peptide Immobilization Techniques on a QCM Surface Related to Acetaldehyde Responses in the Gas Phase.

Sensors (Basel) 2018 Nov 14;18(11). Epub 2018 Nov 14.

Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, Gabriela Narutowicza 11/12, 80-233 Gdansk, Poland.

The quartz-crystal microbalance is a sensitive and universal tool for measuring concentrations of various gases in the air. Biochemical functionalization of the QCM electrode allows a label-free detection of specific molecular interactions with high sensitivity and specificity. In addition, it enables a real-time determination of its kinetic rates and affinity constants. Read More

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http://dx.doi.org/10.3390/s18113942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264005PMC
November 2018
3 Reads

The efficacy and cytotoxicity of iron oxide-carbon black composites for liquid-phase toluene oxidation by persulfate.

Environ Sci Pollut Res Int 2018 Nov 1. Epub 2018 Nov 1.

Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.

This study evaluated the oxidation of toluene (TOL) by persulfate (PS) in aqueous solution in the presence of a FeO-carbon black (CB) composite oxidant system generating sulfate radicals. The cytotoxic activity and oxidative stress generated by these materials were investigated in rat liver Clone 9 cells. The effects of various operating parameters including the pH and concentrations of PS, FeO-CB, and TOL were evaluated to optimize the oxidation process. Read More

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http://link.springer.com/10.1007/s11356-018-3593-7
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http://dx.doi.org/10.1007/s11356-018-3593-7DOI Listing
November 2018
4 Reads

Assessment of multiple anthropogenic contaminants and their potential genotoxicity in the aquatic environment of Plitvice Lakes National Park, Croatia.

Environ Monit Assess 2018 Oct 31;190(11):694. Epub 2018 Oct 31.

Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, PO Box 291, 10001, Zagreb, Croatia.

In this study, the influence of anthropogenic pollution on the aquatic environment of Plitvice Lakes National Park (PLNP) was investigated during 2011-2012 using a combination of chemical and cytogenetic analyses. Four groups of major contaminants [(volatile organic compounds: benzene, toluene, ethylbenzene, and xylenes (BTEX); persistent organochlorine pollutants: organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs); major and trace elements; anthropogenic radionuclides (Sr, Cs, and Cs)] were determined in three aquatic compartments (water, sediment, fish). Mass fractions of inorganic constituents in different compartments reflected the geological background of the area, indicating their origin from predominantly natural sources. Read More

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http://dx.doi.org/10.1007/s10661-018-7028-1DOI Listing
October 2018
4 Reads

Selective Photokilling of Human Pancreatic Cancer Cells Using Cetuximab-Targeted Mesoporous Silica Nanoparticles for Delivery of Zinc Phthalocyanine.

Molecules 2018 Oct 24;23(11). Epub 2018 Oct 24.

Institut Quimic de Sarria, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain.

Background: Photodynamic therapy (PDT) is a non-invasive and innovative cancer therapy based on the photodynamic effect. In this study, we sought to determine the singlet oxygen production, intracellular uptake, and in vitro photodynamic therapy potential of Cetixumab-targeted, zinc(II) 2,3,9,10,16,17,23,24-octa(tert-butylphenoxy))phthalocyaninato(2-)-N,N,N,N (ZnPcOBP)-loaded mesoporous silica nanoparticles against pancreatic cancer cells.

Results: The quantum yield () value of ZnPcOBP was found to be 0. Read More

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http://dx.doi.org/10.3390/molecules23112749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278564PMC
October 2018
21 Reads

Lethality of synthetic and natural acaricides to worker honey bees (Apis mellifera) and their impact on the expression of health and detoxification-related genes.

Environ Sci Pollut Res Int 2018 Dec 15;25(34):34730-34739. Epub 2018 Oct 15.

School of Environmental Sciences, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

In this study, honey bees (Apis mellifera L.) were exposed to LD and LD doses of five commonly used acaricides for controlling the parasitic mite, Varroa destructor. LD values at 48 h post-treatment showed that tau-fluvalinate was the most toxic, followed by amitraz, coumaphos, thymol, and formic acid. Read More

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http://link.springer.com/10.1007/s11356-018-3205-6
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http://dx.doi.org/10.1007/s11356-018-3205-6DOI Listing
December 2018
7 Reads

The Correlation Between Length of Work and Nasal Mucociliary Transport Time of Gas/Fuel Station Workers.

Kobe J Med Sci 2018 May 28;64(1):E6-E10. Epub 2018 May 28.

Department of Ear Nose Throat-Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Yogyakarta, Indonesia.

Gasoline contains toxic substances such as benzene, toluene, ethylbenzene, xylene (BTEX) that negatively influence gas/fuel station workers' health via continuous inhalation, causing loss of cilia and epithelial cell necrosis of the nasal mucosa. The aim of this study is to determine the correlation between length of work with nasal mucociliary transport time (NMCTT) of the gas/fuel station workers This study used a cross sectional design. The data were obtained from anamnesis, physical and NMCTT examinations of gas station workers in Yogyakarta, during November 2013. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192822PMC
May 2018
3 Reads

Reuse of materials from a Sustainable Drainage System device: Health, Safety and Environment assessment for an end-of-life Pervious Pavement Structure.

Sci Total Environ 2019 Feb 26;650(Pt 2):1759-1770. Epub 2018 Sep 26.

GITECO-UC, Univ. of Cantabria, Avda de los Castros s/n. 39005, Santander, Spain.

Pervious pavement systems can have a life span of about 20years but, at end-of-life, it becomes necessary to evaluate the state of the infrastructure to determine whether they pose a health and safety risk to workers during dismantling, and also determine potential reuse of the waste material generated. In this paper, we report of an investigation conducted to evaluate whether Pervious pavement systems are hazardous to human health at end-of-life and also to assess the mobility of the stormwater pollutants trapped in the system as a measure of their potential release to receiving systems such as water-bodies and groundwater systems. After decommissioning, the pervious pavement structure was sampled for analysis including Gas Chromatography, inductively coupled plasma spectroscopy and, leachate analysis. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.224DOI Listing
February 2019
2 Reads

Safety liver profile of teriflunomide versus interferon β in multiple sclerosis: Systematic review and indirect comparison meta-analysis.

Mult Scler Relat Disord 2018 Nov 22;26:192-200. Epub 2018 Sep 22.

Fundación Cardioinfantil, Instituto de Cardiologia, Bogotá, Colombia; Grupo de investigación en neurociencias NeURos, School of medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; Hospital Universitario Mederi, Bogotá, Colombia.

Objectives: To compare the liver safety profile of interferon β (IFN β) and teriflunomide in patients with multiple sclerosis.

Methods: A network meta-analysis was carried out following the Cochrane Collaboration methodology. All trials comparing all types of IFN β with teriflunomide, or disease-modifying drugs, or placebo in RRMS were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183032
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http://dx.doi.org/10.1016/j.msard.2018.09.014DOI Listing
November 2018
11 Reads

[Study on the health effects of occupational exposure to low concentrations of benzene].

Authors:
Y M Cao W M Gao J Liu

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Jun;36(6):435-438

No. 5 Suzhou People's Hospital, Suzhou 215137, China.

The main purpose of this study was to ascertain whether (or not) exposure to benzene, toluene, xylene and ethylbenzene (BTXE) , under normal working conditions, was associated with any health effects. From January to December 2014, the workplaces concentrations of BTXE were measured of 71 enterprises in Suzhou Industrial Park. Occupational health examination were investigated on 764 employees who exposed to BTXE, as well as 4409 employees of the corresponding enterprises who unexposed to BTXE, and analyzed the data of the two groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.06.010DOI Listing
June 2018
18 Reads

Medico-legal implications of toluene abuse and toxicity. Review of cases along with blood concentrations.

Leg Med (Tokyo) 2018 Sep 23;34:48-57. Epub 2018 Aug 23.

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, 40126 Bologna, Italy. Electronic address:

Toluene, a liquid aromatic hydrocarbon, is one of the most widely used industrial solvents, and is present in numerous paints, paint thinners, glues and other industrial and household products. It has become the most abused solvent in the world due to its rapid effects following inhalation. However, the numerous cases of fatal and non-fatal toluene-related intoxication reported in the literature have not yet been collected and discussed in the forensic setting. Read More

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http://dx.doi.org/10.1016/j.legalmed.2018.08.008DOI Listing
September 2018
3 Reads

Herbicide Toxicity to Soybean-Rhizobium Symbiosis as Affected by Soil pH.

Bull Environ Contam Toxicol 2018 Oct 17;101(4):434-438. Epub 2018 Aug 17.

Department of Agronomy and Plant Breeding, Faculty of Agriculture, Bu-Ali Sina University, Hamadan, Islamic Republic of Iran.

The current study examined whether soil pH could influence the toxicity of herbicides to soybean-rhizobium symbiosis. This can be useful for farmers to minimize the toxicity of them to crop-rhizobium symbiosis via applying their reduced doses. The toxicity of bentazon, metribuzin, and trifluralin to soybean-rhizobium symbiosis was investigated in pH 6. Read More

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http://dx.doi.org/10.1007/s00128-018-2417-2DOI Listing
October 2018
6 Reads

Silica-Nanochannel-Based Interferometric Sensor for Selective Detection of Polar and Aromatic Volatile Organic Compounds.

Anal Chem 2018 09 24;90(18):10780-10785. Epub 2018 Aug 24.

Institute of Analytical Chemistry, Department of Chemistry , Zhejiang University , Hangzhou 310058 , China.

Public awareness of the toxicity of volatile organic compounds (VOCs) has led to increased requirements for direct measurement of these substances. This work reports the sensitive detection of VOCs at the ppb level by an interferometric sensor based on the multilayer silica-nanochannel membrane (MSNM). The MSNM is fabricated by layer-by-layer stacking of a free-standing ultrathin SNM composed of regularly ordered channels with an ultrasmall diameter of about 2. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b01681DOI Listing
September 2018
11 Reads

Exposure to amitraz, fipronil and permethrin affects cell viability and ABC transporter gene expression in an Ixodes ricinus cell line.

Parasit Vectors 2018 Jul 31;11(1):437. Epub 2018 Jul 31.

Department of Veterinary Sciences, University of Parma, 43126, Parma, Italy.

Background: Over-expression of ATP-binding cassette (ABC) transporter proteins has been implicated in resistance of ticks to acaricides. Tick cell lines are useful for investigating resistance mechanisms, as development of an in vitro model for the study of acaricide resistance would contribute to improving knowledge of the molecular basis behind drug processing and exclusion in ticks. In the present study, cultures of the Ixodes ricinus-derived cell line IRE/CTVM19 were treated with the acaricides amitraz, permethrin or fipronil to determine modulation of ABC transporter gene expression. Read More

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http://dx.doi.org/10.1186/s13071-018-3020-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069974PMC
July 2018
2 Reads

Growth changes after inhalant abuse and toluene exposure: A systematic review and meta-analysis of human and animal studies.

Hum Exp Toxicol 2019 Feb 31;38(2):157-172. Epub 2018 Jul 31.

1 Addiction Neuroscience, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Victoria, Australia.

Inhalant abuse is a significant public health issue, particularly for adolescents, the predominant group of inhalant users. Adolescence is a critical growth period, and inhalant abuse has been associated with growth impairments, including reduced body weight and height. However, the extent to which inhalant abuse affects growth remains unquantified, and potential moderators remain unknown. Read More

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http://dx.doi.org/10.1177/0960327118792064DOI Listing
February 2019
14 Reads

Development and Validation of an Analytical Method to Quantitate Tris(chloroisopropyl)phosphate in Rat and Mouse Plasma using Gas Chromatography with Flame Photometric Detection.

J Anal Toxicol 2019 Jan;43(1):36-44

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, 111 Alexander Dr., Research Triangle Park, NC, USA.

Tris(chloropropyl)phosphate (TCPP) is an organophosphorus flame retardant (OPFR) and plasticizer increasingly used in consumer products and as a replacement for brominated flame retardants. Commercially available TCPP is a mixture of four structural isomers the most abundant of which is tris(1-chloro-2-propyl)phosphate (TCPP-1). Although there is a widespread use of TCPP and potential for human exposure, there is limited data on the safety or toxicity of TCPP. Read More

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http://dx.doi.org/10.1093/jat/bky048DOI Listing
January 2019

Chronic near lifetime toluene exposure in rodents does not replicate solvent abuse leukoencephalopathy in humans.

Neurotoxicology 2018 12 26;69:260-265. Epub 2018 Jul 26.

Department of Pathology, University of Manitoba, Winnipeg Canada; Children's Hospital Research Institute of Manitoba, Winnipeg Canada. Electronic address:

Toluene is an organic solvent used in industry and as a substance of abuse. The latter situation may be associated with a leukoencephalopathy characterized by white matter atrophy, multifocal myelin loss, and macrophages that contain birefringent granular inclusions. To determine if rodents can develop the same white matter damage, we studied archived rodent brain samples from three near-lifetime toluene carcinogenicity experiments. Read More

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http://dx.doi.org/10.1016/j.neuro.2018.07.013DOI Listing
December 2018
1 Read

Synthesis of N-aryl substituted p-toluenesulphonamides via nickel catalyzed amidation reaction and their antibacterial, antifungal and antioxidant activities evaluation.

Pak J Pharm Sci 2018 Jul;31(4):1209-1216

Synthetic Medicinal Chemistry Unit, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka.

In present study nickel catalyzed synthesis of N-(aryl) substituted p-toluene sulphonamides is reported. The intermediate 4-methylbenzenesulphonamide (2) was obtained by the reaction between p-toluene sulphonyl chloride and ammonium hydroxide. Various readily available aryl halides (3a-e) Substituted p-toluene sulphonamides (4a-e) were obtained by coupling 4-methylbenezenesulphonamide (2) with via Buchwald-Hartwig cross-coupling reaction. Read More

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July 2018
26 Reads

Enhancement effect of earthworm (Eisenia fetida) on acetochlor biodegradation in soil and possible mechanisms.

Environ Pollut 2018 Nov 12;242(Pt A):728-737. Epub 2018 Jul 12.

Agro-Environmental Protection Institute, Ministry of Agriculture, MOA Key Laboratory of Original Agro-Environmental Pollution Prevention and Control, Tianjin 300191, China; College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Acetochlor is a widely used chloroacetanilide herbicide and has posed environmental risks in soil and water due to its toxicity and high leaching capacity. Earthworm represents the dominant invertebrate in soil and can promote the decomposition of organic pollutants. The effect of earthworm on acetochlor degradation in soil was studied by soil column experiment with or without acetochlor and earthworm in sterile and natural soils. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183034
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http://dx.doi.org/10.1016/j.envpol.2018.07.029DOI Listing
November 2018
35 Reads

Novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties.

J Biochem Mol Toxicol 2018 Sep 10;32(9):e22191. Epub 2018 Jul 10.

Department of Chemistry, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey.

The thiolation reaction was carried out in a benzene solution at 80°C and p-substituted ketones and mercaptoacetic acid in a molar ratio (1:4) of in the presence of a catalytic amount of toluene sulfonic acids. The enzyme inhibition activities of the novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives were investigated. These novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). Read More

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http://dx.doi.org/10.1002/jbt.22191DOI Listing
September 2018
7 Reads
1.925 Impact Factor

Effect of ozone injection on the long-term performance and microbial community structure of a VOCs biofilter.

J Environ Sci (China) 2018 Jul 23;69:133-140. Epub 2017 Sep 23.

Environmental Simulation and Pollution Control State Key Joint Laboratory, School of Environment, Tsinghua University, Beijing 100084, China; Key Laboratory of Microorganism Application and Risk Control of Shenzhen, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. Electronic address:

For biofilters treating waste gases containing volatile organic compounds (VOCs), biomass accumulation is a common problem which will induce bed clogging and significant decrease in VOCs removal efficiency during long-term operation. In this study, ozone injection was developed as a biomass control strategy, and its effects on the biofilter performance and the microbial community structure were investigated in long-term operation. Two biofilters, identified as BF1 and BF2, were operated continuously for 160 days treating gaseous toluene under the same conditions, except that 200 mg/m ozone was continuously injected into BF1 during days 45-160. Read More

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http://dx.doi.org/10.1016/j.jes.2017.09.008DOI Listing
July 2018
5 Reads

Toluene diisocyanate exposure and autotaxin-lysophosphatidic acid signalling.

Toxicol Appl Pharmacol 2018 09 22;355:43-51. Epub 2018 Jun 22.

Division of Occupational and Environmental Medicine, Lund University, SE 221 85 Lund, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE171 77 Stockholm, Sweden. Electronic address:

Toluene diisocyanate (TDI) is a reactive chemical used in manufacturing plastics. TDI exposure adversely affects workers' health, causing occupational asthma, but individuals differ in susceptibility. We recently suggested a role for signalling mediated by the enzyme autotaxin (ATX) and its product, lysophosphatidic acid (LPA), in TDI toxicity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183028
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http://dx.doi.org/10.1016/j.taap.2018.06.019DOI Listing
September 2018
25 Reads

Attenuation of toluene-induced brain stimulation reward enhancement and behavioral disturbances by N-acetylcysteine in mice.

Toxicology 2018 09 21;408:39-45. Epub 2018 Jun 21.

Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien, 97004, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan; Research Center for Mind, Brain, and Learning, National Chengchi University, 64, Sec. 2, ZhiNan Road, Wenshan District, Taipei City 11605, Taiwan. Electronic address:

Toluene, a commonly used organic solvent, produces a variety of behavioral disturbances in both humans and animals comparable to noncompetitive N-methyl-D-aspartate receptor (NMDARs) antagonists, such as phencyclidine (PCP). N-acetylcysteine (NAC) is capable of reversing the psychotomimetic effects of PCP via activation of cystine-glutamate antiporters (xCT). The present study examined whether NAC is capable of attenuating the toluene-induced brain stimulation reward enhancement and behavioral manifestations. Read More

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http://dx.doi.org/10.1016/j.tox.2018.06.011DOI Listing
September 2018
29 Reads

Biodegradation of gaseous emissions of 2-chlorotoluene by strains of Rhodococcus sp. in polyurethane foam packed biotrickling filters.

Sci Total Environ 2018 Oct 28;639:1491-1500. Epub 2018 May 28.

Institute of Sanitary Engineering, Water Quality and Solid Waste Management, University of Stuttgart, Bandtäle 2, Stuttgart 70569, Germany.

About 60,000-70,000 tons of 2-chlorotoluene, which shows high toxicity in aquatic ecosystems, are produced worldwide and used in a tremendous field of applications. However, clear proofs of biodegradation were only presented for Comamonas testosteroni KT5 and Rhodococcus sp. OCT10. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.05.278DOI Listing
October 2018
4 Reads

Participation of voltage-gated sodium and calcium channels in the acute cardiac effects of toluene.

Toxicol Mech Methods 2018 Nov 31;28(9):670-677. Epub 2018 Jul 31.

c Facultad de Ciencias Médicas y Biológicas "Dr. Ignacio Chávez" , Universidad Michoacana de San Nicolás de Hidalgo, Dr. Rafael Carrillo esquina Dr. Salvador González Herrejón, Col. Bosque Cuauhtémoc , Morelia , Mexico.

Inhaling solvents can lead to occurrence of cardiac arrhythmias and sudden sniffing death. Mechanisms related to this phenomenon are not fully understood. The purpose of this study was to investigate the effect of acute toluene exposure on heart reactivity to epinephrine and the participation of voltage-gated sodium and calcium channels. Read More

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http://dx.doi.org/10.1080/15376516.2018.1491664DOI Listing
November 2018
14 Reads

Synthesis, crystal structure, and cytotoxicity studies of titanacalix[4 and 8]arene complexes.

Dalton Trans 2018 Jul;47(27):8992-8999

Chemistry, School of Mathematics and Physical Sciences, University of Hull, Hull, HU6 7RX, UK.

Reaction of 5,11,17,23-tetra-tert-butyl-dihydroxy-26,28-bis(2-pentoxy)calix[4]arene (L(OH)2(Opentyl)2) with [TiCl4] afforded the dichlorotitanoacalix[4]arene complex [TiCl2L(O)2(Opentyl)2] (1) in good yield. Hydrolysis of 1 led to the isolation of the complex {[TiL(O)3(Opentyl)]2(μ-OH)(μ-Cl)} (2). Reaction of 5,11,17,23,29,35,41,47-p-tert-butyl-49,50,51,52,53,54,55,56-octapropoxycalix[8]arene (L'(Opropyl)8) with [TiCl4] in refluxing toluene afforded, following work-up, a 35 : 65 mixture (3) of the complex [Ti(NCMe)Cl]2[TiCl(μ-O)]2L' and the silicone grease derived complex [Ti(NCMe)Cl]2[Ti(μ-O)]2[OSi(CH3)2OSi(CH3)2O]L' in which the grease replaces two chloride ligands. Read More

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http://dx.doi.org/10.1039/c8dt01992dDOI Listing
July 2018
6 Reads

Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory.

Environ Health Prev Med 2018 Jun 19;23(1):24. Epub 2018 Jun 19.

Department of Environment Health, University of Occupational and Environmental Health, Kitakyushu, Japan.

Background: Plastic resins are complex chemicals that contain toluene diisocyanate (TDI) and/or trimellitic anhydride (TMA), which cause occupational allergies (OA), including respiratory allergies. Serum IgGs against TDI and TMA have been suggested as potential markers of the exposure status and as exploring cause of OA. Although TDI-specific IgG has been examined for suspected OA, TMA-specific IgG is not commonly evaluated in a urethane foam factory. Read More

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http://dx.doi.org/10.1186/s12199-018-0713-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010152PMC
June 2018
3 Reads

Draft genome sequence of Rhodococcus erythropolis B7g, a biosurfactant producing actinobacterium.

J Biotechnol 2018 Aug 4;280:38-41. Epub 2018 Jun 4.

Institute of Biosciences, Chemistry and Physics Faculty, TU Bergakademie Freiberg, 09599, Freiberg, Germany; Microbial Biotechnology, Ruhr University Bochum, 44780, Bochum, Germany. Electronic address:

Biosurfactants are amphipathic molecules with relevance in biotechnology due to their structural diversity, low toxicity and biodegradability. The genus Rhodococcus has extensively been studied because of its capacity to produce trehalose-containing surfactants as well as trehalose lipids as potential pathogenic factor. Here we present the draft genome sequence of Rhodococcus erythropolis B7g isolated with toluene from fuel-contaminated soil. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2018.06.001DOI Listing
August 2018
5 Reads

Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark).

Scand J Work Environ Health 2018 11 7;44(6):658-669. Epub 2018 Jun 7.

Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France.

Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. Read More

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http://www.sjweh.fi/show_abstract.php?abstract_id=3732
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http://dx.doi.org/10.5271/sjweh.3732DOI Listing
November 2018
8 Reads

Green synthesis and characterizations of gold nanoparticles using Thyme and survey cytotoxic effect, antibacterial and antioxidant potential.

J Photochem Photobiol B 2018 Jul 19;184:71-79. Epub 2018 May 19.

Department of Chemistry, Payame Noor University, Tehran, Iran. Electronic address:

Nowadays, green chemistry methods are noticeable for synthesis metal nanoparticles due to affordable, easy and high reaction rate. In the present study gold nanoparticles (Au NPs) were eco-friendly synthesized using Thyme extract at the room temperature for 30 min to provide non-toxic, which can be used for different applications. Identifying properties of synthesized gold nanoparticles was done by various analytical technique including UV-Vis absorption spectroscopy approved presence of Au NPs in the solution, the functional groups of Thyme extract in the reduction and capping process of Au NPs are determined by FT-IR, Crystalline with the fcc plane approved by X-ray diffraction (XRD) pattern, energy dispersive spectroscopy (EDS) determined existence of elements in the sample, surface morphology, diverse shapes and size of present Au NPs were showed by scanning electron microscopy (SEM), atomic force microscopy (AFM) and Transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.05.016DOI Listing
July 2018
5 Reads

[Indirect and mixed mechanisms of action in toxic myopathies].

Ann Pharm Fr 2018 Jul 24;76(4):273-285. Epub 2018 May 24.

Service de toxicologie, CHU Bab-El-Oued, rue Mohamed Lamine Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du petit Staouali Delly Brahim, 16062 Alger, Algérie.

Toxic myopathies are a group of pathologies characterized by a structural and/or functional disturbance of muscles induced by an exogenous agent. The most frequent are those induced by drugs used in clinical practice. Illegal drugs, pesticides, solvents, metals and even physical and gaseous agents can cause this kind of disease and exert toxicity on muscle tissues. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.004DOI Listing
July 2018
6 Reads

An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine.

J Occup Health 2018 Jul 9;60(4):307-311. Epub 2018 May 9.

National Institute of Occupational Safety and Health.

Background: ortho-Toluidine (OT) was listed as a Group 1 carcinogen by the International Agency for Research on Cancer in 2012 based on epidemiological observations of workers co-exposed to OT and aromatic amines. From 2014 to 2017, several cases of bladder cancer (BCa) secondary to occupational exposure, primarily to OT, were detected in Japan.

Objective: To describe 10 cases of BCa in male Japanese workers exposed primarily to OT at two plants that produce organic dye and pigment intermediates. Read More

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http://dx.doi.org/10.1539/joh.2017-0220-OADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078838PMC
July 2018
2 Reads