3,179 results match your criteria Toxicity Thyroid Hormone


Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish.

Sci Total Environ 2019 Feb 13;665:855-863. Epub 2019 Feb 13.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Although 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), an alternative to perfluorooctanesulfonate (PFOS), has been regularly detected in different environmental matrices, information regarding its toxicity remains limited. To explore the transgenerational thyroid-disrupting capacity of F-53B, adult zebrafish (F0) were exposed to different concentrations of F-53B (0, 5, 50, or 500μg/L) for 180d, with their offspring (F1 and F2) subsequently reared in uncontaminated water. Thyroid disturbances were then examined in the three (F0, F1, and F2) generations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.198DOI Listing
February 2019

Proteome changes in methylmercury-exposed mouse primary cerebellar granule neurons and astrocytes.

Toxicol In Vitro 2019 Feb 15. Epub 2019 Feb 15.

Department of Biology, University of Ottawa, Canada. Electronic address:

Methylmercury (MeHg) is a neurotoxicant, with the cerebellum as the main target of toxicity; however, the toxic effects of MeHg on specific cell types remain unclear. Here, primary cerebellar granule neurons (CGNs) and cerebellar astrocytes were isolated and analyzed for total mercury accumulation, cellular reactive oxygen species (ROS) production, and whole-cell proteome expression after exposure to 0-10 μM MeHg for 24 h. Intracellular mercury and ROS levels showed dose-dependent increases. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.013DOI Listing
February 2019

Toxicity of Pexacerfont, a Corticotropin-Releasing Factor Type 1 Receptor Antagonist, in Rats and Dogs.

Int J Toxicol 2019 Feb 13:1091581819827501. Epub 2019 Feb 13.

2 Evansville, IL, USA.

Pexacerfont is a corticotropin-releasing factor subtype 1 receptor antagonist that was developed for the treatment of anxiety- and stress-related disorders. This report describes the results of repeat-dose oral toxicity studies in rats (3 and 6 months) and dogs (3 months and 1 year). Pexacerfont was well tolerated in all of these studies at exposures equal to or greater than areas under the curve in humans (clinical dose of 100 mg). Read More

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http://dx.doi.org/10.1177/1091581819827501DOI Listing
February 2019
1 Read

Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor.

Sci Total Environ 2019 Feb 5;653:1140-1148. Epub 2018 Nov 5.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

Acetochlor (ACT) is a chiral chloroacetamide pesticide that has been heavily used around the world, resulting in its residues being frequently found in surface waters. It has been reported that ACT is an endocrine disrupting chemical (EDC) with strong thyroid hormone-disrupting activity in aquatic organisms. However, the enantioselectivity underlying thyroid disruption has yet to be understood. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.037DOI Listing
February 2019

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Food Chem Toxicol 2019 Feb 5;126:1-6. Epub 2019 Feb 5.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.004DOI Listing
February 2019
1 Read

Transgenerational endocrine disruption: Does elemental pollution affect egg or nestling thyroid hormone levels in a wild songbird?

Environ Pollut 2019 Jan 23;247:725-735. Epub 2019 Jan 23.

Department of Biology, University of Turku, 20014, Turku, Finland.

Endocrine disrupting chemicals (EDCs) include a wide array of pollutants, such as some metals and other toxic elements, which may cause changes in hormonal homeostasis. In addition to affecting physiology of individuals directly, EDCs may alter the transfer of maternal hormones to offspring, i.e. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.088DOI Listing
January 2019
1 Read

Cytotoxicity against fish and mammalian cell lines and endocrine activity of the mycotoxins beauvericin, deoxynivalenol and ochratoxin-A.

Food Chem Toxicol 2019 Feb 1. Epub 2019 Feb 1.

Department of Environment, National Institute for Agricultural and Food Research and Technology (INIA), Carretera de la Coruña km 7, 28040, Madrid, Spain. Electronic address:

The toxicity of mycotoxins is well recognized in mammals, but their effects on fish have received less attention. Moreover, in the last years several studies have reported that some mycotoxins may act as endocrine disruptors. The aim of this study was to determine the cytotoxic effects and endocrine activities of three mycotoxins, beauvericin, deoxynivalenol and ochratoxin-A. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.036DOI Listing
February 2019

Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats.

Environ Sci Pollut Res Int 2019 Jan 29. Epub 2019 Jan 29.

Department of Biological Sciences, Faculty of Science, College of Science, King Faisal University, Hofuf, Al-Ahsa, 31982, Saudi Arabia.

The aim of this study was to evaluate the probable protective effect of quercetin (QUE) against cadmium (Cd)-induced sub-chronic toxicity in rats. Adult male rats were given either Cd (as cadmium chloride; 5 mg/kg) alone or in combination with QUE (50 mg/kg) daily for 4 weeks by oral gavage. At the end of the experimental period, Cd accumulation, and selected hematological, thyroid, and reproductive markers were assessed. Read More

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http://link.springer.com/10.1007/s11356-019-04276-1
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http://dx.doi.org/10.1007/s11356-019-04276-1DOI Listing
January 2019
4 Reads
2.828 Impact Factor

Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae.

Metallomics 2019 Jan 28. Epub 2019 Jan 28.

Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada. and Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada.

Mercury is one of the most toxic elements threatening the biosphere, with levels steadily rising due to both natural and human activities. Selenium is an essential micronutrient, required for normal development and functioning of many organisms. While selenium is known to counteract mercury's toxicity under some conditions, to date information about the mercury-selenium relationship is fragmented and often controversial. Read More

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http://xlink.rsc.org/?DOI=C8MT00315G
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http://dx.doi.org/10.1039/c8mt00315gDOI Listing
January 2019
2 Reads

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.

Pharm Biol 2019 Dec;57(1):29-37

a Key Laborotory Experimental Marine Biology, Institute of Oceanology , Chinese Academy of Sciences , Qingdao , China.

Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system.

Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Read More

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http://dx.doi.org/10.1080/13880209.2018.1563621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346718PMC
December 2019
2 Reads

Prevention & control of fluorosis & linked disorders: Developments in the 21 Century - Reaching out to patients in the community & hospital settings for recovery.

Indian J Med Res 2018 Nov;148(5):539-547

Centre for Promotion of Nutrition Research and Training with special focus on North East, tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

The review on fluorosis addresses the genesis of the disease, diagnostic protocols developed, mitigation and recovery through nutritional interventions. It reveals the structural and functional damages caused to skeletal muscle and erythrocytes, leading to clinical manifestations in fluorosis. Hormonal derangements resulting in serious abnormalities in the health of children and adults are discussed. Read More

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http://www.ijmr.org.in/text.asp?2018/148/5/539/249979
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http://dx.doi.org/10.4103/ijmr.IJMR_1775_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366265PMC
November 2018
14 Reads

Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.

J Med Chem 2019 Feb 4. Epub 2019 Feb 4.

New Drug Development Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , South Korea.

An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to radioiodine therapy in vitro. We synthesized potent, selective, and orally bioavailable ERRγ-inverse agonists and evaluated their activity by analyzing in vitro pharmacology and absorption, distribution, metabolism, excretion, and toxicity profiles. X-ray crystallographic analysis of the ligand and ERRγ complex showed that 35 completely binds to the target protein (PDB 6A6K ). Read More

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01296
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http://dx.doi.org/10.1021/acs.jmedchem.8b01296DOI Listing
February 2019
9 Reads

Organophosphate Ester, 2-Ethylhexyl Diphenyl Phosphate (EHDPP), Elicits Cytotoxic and Transcriptomic Effects in Chicken Embryonic Hepatocytes and Its Biotransformation Profile Compared to Humans.

Environ Sci Technol 2019 Feb 1;53(4):2151-2160. Epub 2019 Feb 1.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.

The effects of 2-ethylhexyl diphenyl phosphate (EHDPP) on cytotoxicity and mRNA expression, as well as its metabolism, were investigated using a chicken embryonic hepatocyte (CEH) assay. After incubation for 36 h, the lethal concentration 50 (LC) was 50 ± 11 μM, suggesting that EHDPP is one of a small cohort of highly toxic organophosphate esters (OPEs). By use of a ToxChip polymerase chain reaction (PCR) array, we report modulation of 6, 11, or 16/43 genes in CEH following exposure to 0. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.8b06246
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http://dx.doi.org/10.1021/acs.est.8b06246DOI Listing
February 2019
6 Reads

Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study.

Mol Autism 2019 9;10. Epub 2019 Jan 9.

1Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.

Background: Evidence has indicated that some non-inherited factors such as exposure to environmental pollutants are associated with neurodevelopment disorders like autism spectrum disorder (ASD). Studies report that endocrine disrupting compounds (EDCs), including polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances (PFAS), and some metals, have adverse effects on the fetal neurodevelopment. The aim of this study was to measure the amniotic fluid (AF) levels of EDCs and metals as well as the receptor transactivities induced by AF and investigate the possible link between prenatal exposure to EDCs and heavy metals and ASD risk. Read More

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https://molecularautism.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13229-018-0253-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327542PMC
February 2019
4 Reads

Amphibian (Rana nigromaculata)exposed to cyproconazole: Changes in growth index, behavioral endpoints, antioxidant biomarkers, thyroid and gonad development.

Aquat Toxicol 2019 Mar 3;208:62-70. Epub 2019 Jan 3.

Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing, 100193, China. Electronic address:

Pesticides are a major cause of reduction in the global population of amphibians. This study investigates the effect of varying concentrations of cyproconazole (1 and 10 mg/L) on Rana nigromaculata during a chronic 90 days exposure period. High levels of cyproconazole (10 mg/L) induced declined body weight, short snout-vent length, slow metamorphic development and abnormal behavioral endpoints in R. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183092
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http://dx.doi.org/10.1016/j.aquatox.2018.12.015DOI Listing
March 2019
4 Reads
3.451 Impact Factor

Enantioselectivity in endocrine disrupting effects of four cypermethrin enantiomers based on in vitro models.

Chemosphere 2019 Apr 28;220:766-773. Epub 2018 Dec 28.

College of Environment, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address:

Cypermethrin (CP) is a kind of chiral pesticides that has been defined as endocrine disrupting chemical. The diversity in bioactivity, toxicity, metabolism, bioaccumulation, and degradation behaviors of CP enantiomers as well as the research deficiency had made the risk assessment of CP enantiomers very complicated. Herein, four CP enantiomers were separated as target chemicals to investigate their enantioselective endocrine disrupting effects. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.158DOI Listing

Insecticide pyriproxyfen (Dragón) damage biotransformation, thyroid hormones, heart rate, and swimming performance of Odontophrynus americanus tadpoles.

Chemosphere 2019 Apr 2;220:714-722. Epub 2019 Jan 2.

Ecotoxicology Laboratory, Faculty of Biochemistry and Biological Sciences, FBCB-UNL, Ciudad Universitaria, Paraje el Pozo s/n (3000), Santa Fe, Argentina. Electronic address:

Odontoprynus americanus tadpoles were used to determine the safety concentration of pyriproxyfen (PPF) insecticide by acute and sublethal toxicity tests (nominal range tested 0.01 to 10 [± 15%] PPF mg/L). Median lethal concentration (LC) and no, and lowest-observed-effect concentrations (NOEC and LOEC, respectively) were calculated. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.181DOI Listing

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules.

Chemosphere 2019 Mar 17;218:885-894. Epub 2018 Nov 17.

Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131, Naples, Italy; Consorzio Interuniversitario INBB, Viale Medaglie d'Oro, 305, I-00136, Rome, Italy. Electronic address:

Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of environmental pollution, most of which exerting endocrine-disrupting activity, in thyroid cancer development. The increasing incidence of differentiated thyroid cancer (DTC) may be related to the rising production and environmental dissemination of pollutants. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.084DOI Listing
March 2019
4 Reads

Is the current-use flame retardant, DBE-DBCH, a potential obesogen? Effects on body mass, fat content and associated behaviors in American kestrels.

Ecotoxicol Environ Saf 2019 Mar 29;169:770-777. Epub 2018 Nov 29.

Ecotoxicology & Wildlife Health Division, Science & Technology Branch, Environment and Climate Change Canada, Burlington, Ontario, Canada. Electronic address:

The current-use brominated flame retardant, 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (DBE-DBCH), is capable of perturbing sex steroid and thyroid hormone pathways in vitro and in vivo. Chemicals with this capability may also disrupt metabolic processes and are candidate obesogens, but this potential has not yet been determined for DBE-DBCH. Our objective was to examine gross biomarkers of metabolic disruption in captive American kestrels. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.104DOI Listing

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases.

Toxicol Sci 2018 Dec 18. Epub 2018 Dec 18.

U.S. Environmental Protection Agency, Duluth, Minnesota.

Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical inhibition of deiodinase activity has been identified as an important endpoint to include in screening chemicals for thyroid hormone disruption. To address the lack of data regarding chemicals that inhibit the deiodinase enzymes, we developed robust in vitro assays that utilized human deiodinase types 1, 2, and 3 and screened over 1,800 unique chemicals from the U. Read More

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http://dx.doi.org/10.1093/toxsci/kfy302DOI Listing
December 2018
2 Reads

Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development.

Chemosphere 2019 Mar 8;219:517-525. Epub 2018 Dec 8.

Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Hangzhou, 310021, Zhejiang, China. Electronic address:

Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.061DOI Listing
March 2019
2 Reads

Lithium Treatment Is Safe in Children With Intellectual Disability.

Front Mol Neurosci 2018 22;11:425. Epub 2018 Nov 22.

Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lithium is a widely used and effective treatment for individuals with psycho-neurological disorders, and it exhibits protective and regenerative properties in multiple brain injury animal models, but the clinical experience in young children is limited due to potential toxicity. As an interim analysis, this paper reports the safety/tolerability profiles of low-dose lithium treatment in children with intellectual disability (ID) and its possible beneficial effects. In a randomized, single-center clinical trial, 124 children with ID were given either oral lithium carbonate 6 mg/kg twice per day or the same dose of calcium carbonate as a placebo ( = 62/group) for 3 months. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00425
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http://dx.doi.org/10.3389/fnmol.2018.00425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262083PMC
November 2018
12 Reads

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

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http://dx.doi.org/10.26355/eurrev_201811_16434DOI Listing
November 2018
1 Read

Gonadal impairment and parental transfer of tris (2-butoxyethyl) phosphate in zebrafish after long-term exposure to environmentally relevant concentrations.

Chemosphere 2019 Mar 22;218:449-457. Epub 2018 Nov 22.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tris (2-butoxyethyl) phosphate (TBOEP) is a ubiquitous environmental contaminant due to its overuse. TBOEP has been found to cause reproductive toxicity and endocrine disruption during acute toxic experiment. In this study, we examined the effects of TBOEP on growth in initial generation (F0) zebrafish and transgenerational effects on growth of first generation (F1) larvae after parental long-term exposure (120 d) to environmentally relevant concentrations (0, 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.139DOI Listing
March 2019
2 Reads

European Perspective on 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: Proceedings of an Interactive International Symposium.

Thyroid 2019 Jan 7;29(1):7-26. Epub 2019 Jan 7.

18 Department of Endocrinology and Metabolism, Endocrine Tumor Center at WTZ, Essen University Hospital, Essen, Germany.

Background: The American Thyroid Association (ATA) management guidelines for patients with thyroid nodules and differentiated thyroid cancer (DTC) are highly influential practice recommendations. The latest revision appeared in 2015 ("ATA 2015"). These guidelines were developed predominantly by North American experts. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2017.0129
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http://dx.doi.org/10.1089/thy.2017.0129DOI Listing
January 2019
6 Reads

Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin αvβ3.

J Environ Sci (China) 2019 Jan 24;75:1-13. Epub 2018 May 24.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Bisphenol A (BPA) is one of the highest volume industrial products worldwide and has been widely used to make various products as the intermediates of polycarbonate plastics and epoxy resins. Inevitably, general population has been widely exposed to BPA due to extensive use of BPA-containing products. BPA has similar chemical structure with the natural estrogen and has been shown to induce a variety of estrogen-like endocrine effects on organism in vivo or in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10010742173349
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http://dx.doi.org/10.1016/j.jes.2018.05.002DOI Listing
January 2019
8 Reads
2.002 Impact Factor

Endocrine and metabolic adverse effects of immune checkpoint inhibitors: an overview (what endocrinologists should know).

J Endocrinol Invest 2018 Nov 23. Epub 2018 Nov 23.

Department of Human Pathology of Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy.

Immune checkpoint inhibitors (ICIs) are novel anticancer agents, recently introduced with the aim of boosting the immune response against tumors. ICIs are monoclonal autoantibodies that specifically target inhibitory receptors on T cells: cytotoxic T lymphocyte antigen 4 (CTLA4), programmed death 1 (PD-1) and its ligand (PD-1L). ICIs also generate peculiar dysimmune toxicities, called immune-related adverse events (irAEs), that can potentially affect any tissue, and some may be life-threatening if not promptly recognized. Read More

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http://dx.doi.org/10.1007/s40618-018-0984-zDOI Listing
November 2018
8 Reads

Endocrine disruption as an adverse effect of non-endocrine targeting pharmaceuticals.

Environ Sci Pollut Res Int 2019 Jan 22;26(2):1277-1286. Epub 2018 Nov 22.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.

Endocrine disruptors have gained widespread attention owing to their severe adverse health impacts. These produce enormous burden of disease and are associated with high economic cost especially in developed countries. Environmental pollutants causing endocrine disruption include pesticides, industrial wastes, packaging materials, food constituents, plastics, and cosmetic products. Read More

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http://dx.doi.org/10.1007/s11356-018-3774-4DOI Listing
January 2019
11 Reads
2.828 Impact Factor

DINP aggravates autoimmune thyroid disease through activation of the Akt/mTOR pathway and suppression of autophagy in Wistar rats.

Environ Pollut 2019 Feb 30;245:316-324. Epub 2018 Oct 30.

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China. Electronic address:

Di-isononyl phthalate (DINP) is used as a substitute for traditional phthalates, in a wide range of applications. However, there is growing concern regarding its toxicity. Studies have indicated that DINP is related to thyroid hormone disorder and that phthalates can affect thyroid normal function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183282
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http://dx.doi.org/10.1016/j.envpol.2018.10.108DOI Listing
February 2019
8 Reads

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.

Thyroid 2019 Jan 15;29(1):111-123. Epub 2018 Dec 15.

1 Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.

Background: The thyrotropin receptor (TSHR) is the target for autoimmune thyroid stimulating antibodies (TSAb) triggering hyperthyroidism. Whereas elevated thyroid hormone synthesis by the thyroid in Graves' disease can be treated by antithyroid agents, for the pathogenic activation of TSHR in retro-orbital fibroblasts of the eye, leading to Graves' orbitopathy (GO), no causal TSHR directed therapy is available.

Methods: Due to the therapeutic gap for severe GO, TSHR inhibitors were identified by high-throughput screening in Chinese hamster ovary cells expressing the TSHR. Read More

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http://dx.doi.org/10.1089/thy.2018.0349DOI Listing
January 2019
14 Reads

Role of Mitotane in Adrenocortical Carcinoma - Review and State of the art.

Eur Endocrinol 2018 Sep 10;14(2):62-66. Epub 2018 Sep 10.

Unit of Endocrinology, Università Cattolica del Sacro Cuore, Rome, Italy.

Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine tumour deriving from the adrenal cortex. A correct therapeutic strategy requires a multidisciplinary approach between endocrinologist, surgeon and oncologist. Surgery is the mainstay treatment in ACC while mitotane, deriving from the insecticide dichloro-diphenyl-trichloro-ethane, is the main base of the medical treatment of ACC in consideration of its adrenocytolitic activity. Read More

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http://www.touchendocrinology.com/articles/role-mitotane-adr
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http://dx.doi.org/10.17925/EE.2018.14.2.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182924PMC
September 2018
11 Reads

Metabolism of Diflubenzuron in Lizard ( Eremias argus) and Comparative Toxicity of Diflubenzuron and Its Metabolite.

J Agric Food Chem 2018 Nov 29;66(44):11640-11646. Epub 2018 Oct 29.

Research Center for Eco-Environmental Sciences , Chinese Academy of Sciences , Shuangqing RD 18 , Beijing 100085 , China.

The metabolic process of diflubenzuron in rat or fish has been well studied, but little is known about its elimination pathway in lizard. The current study predicted the metabolic route of diflubenzuron in lizard feces and compared the toxicity of diflubenzuron and 4-chloroaniline on lizard thyroid system. The amido bond cleavage was the major route for diflubenzuron elimination in lizard feces. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b03713DOI Listing
November 2018
2 Reads

Protective effect of mulberry crude extract against nonylphenol-induced thyroid disruption by inhibiting the activity of deiodinase in rats.

Gen Comp Endocrinol 2019 01 16;270:90-95. Epub 2018 Oct 16.

College of Food Science, South China Agricultural University, Guangzhou, GZ, China; Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China; Laboratory of Quality and Safety Risk Assessment to Post-harvested Product Storage, Ministry of Agriculture, Guangzhou 510642, China. Electronic address:

Nonylphenol (NP) is an endocrine-disrupting chemical (EDC) that can lead to thyroid disruption. We explored NP-induced toxicity in the rat thyroid and evaluated the mitigating effects of mulberry crude extract (MCE) on NP toxicity. First, we aimed to evaluate NP-induced thyroid disruption by dosing Sprague-Dawley (SD) rats with NP (0, 30, 90, or 270 mg/kg body weight) daily for 28 days. Read More

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http://dx.doi.org/10.1016/j.ygcen.2018.10.010DOI Listing
January 2019
10 Reads

RNA-sequencing to assess the health of wild yellow perch (Perca flavescens) populations from the St. Lawrence River, Canada.

Environ Pollut 2018 Dec 30;243(Pt B):1657-1668. Epub 2018 Sep 30.

Environment and Climate Change Canada, 105 McGill Street, Montréal, QC, H2Y 2E7, Canada.

This study aimed to better understand in situ cumulative effects of anthropogenic stressors on the health of St. Lawrence River (QC, Canada) yellow perch populations using high-throughput transcriptomics and a multi-biological level approach. Fish were collected in the upstream fluvial Lake Saint-François (LSF) with low degree of environmental perturbations; Lake Saint-Louis (LSL) considered having a moderate degree of anthropogenic stressors, and Lake Saint-Pierre (LSP) a sector where the perch population has been severely declining. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183172
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http://dx.doi.org/10.1016/j.envpol.2018.09.133DOI Listing
December 2018
10 Reads

DnBP-induced thyroid disrupting activities in GH3 cells via integrin αβ and ERK1/2 activation.

Chemosphere 2018 Dec 3;212:1058-1066. Epub 2018 Sep 3.

Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address:

Di-n-butylphthalate (DnBP) exhibits alarming thyroid disrupting activities. However, the toxic mechanism of DnBP is not completely understood. In this study, we investigated the mechanism of DnBP in thyroid disruption. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183165
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http://dx.doi.org/10.1016/j.chemosphere.2018.09.007DOI Listing
December 2018
5 Reads

Endocrine disruption, oxidative stress and lipometabolic disturbance of Bufo gargarizans embryos exposed to hexavalent chromium.

Ecotoxicol Environ Saf 2018 Dec 28;166:242-250. Epub 2018 Sep 28.

School of Environmental Science and Engineering, Chang'an University, Xi'an 710054, China; Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Chang'an University Xi'an 710062, China; Shaanxi Key Laboratory of Land Consolidation, Xi'an 710062, China. Electronic address:

The aim of the current study was to determine the potential developmental and metabolic abnormalities caused by Cr (VI) exposure on Bufo gargarizans (B. gargarizans) embryos. B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183097
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http://dx.doi.org/10.1016/j.ecoenv.2018.09.100DOI Listing
December 2018
1 Read

Influences of dissolved humic acid on Zn bioavailability and its consequences for thyroid toxicity.

Ecotoxicol Environ Saf 2018 Dec 25;166:132-137. Epub 2018 Sep 25.

Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address:

This study aimed to investigate the effect of dissolved humic acid (dHA) on Zn bioavailability and the subsequent influence on the Zn-induced thyroid toxicity. Zn toxicity was assessed using a yeast bioassay in the presence and absence of dHA. With increasing concentration of dHA, the toxic effects decreased, and the free Zn concentrations detected by the anodic stripping voltammetry (ASV) method also decreased. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183091
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http://dx.doi.org/10.1016/j.ecoenv.2018.09.051DOI Listing
December 2018
8 Reads

Hexachloronaphthalene (HxCN) as a potential endocrine disruptor in female rats.

Environ Pollut 2018 Dec 17;243(Pt B):1026-1035. Epub 2018 Sep 17.

Department of Toxicology, Faculty of Pharmacy, Medical University, Muszynskiego 1, 90-151, Lodz, Poland. Electronic address:

Hexachloronaphthalene (HxCN) is one of the most toxic and most bioaccumulative congeners of polychlorinated naphthalenes (PCNs) known to be present in animal and human adipose tissue. Unfortunately, little data is available regarding the negative effect of PCNs on endocrine function. The aim of the study was to investigate the direct influence of subacute (two and four-week) and subchronic (13-week) daily oral exposure of female rats to 30, 100 and 300 μg kg b. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183308
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http://dx.doi.org/10.1016/j.envpol.2018.09.045DOI Listing
December 2018
11 Reads

Insights from zebrafish deficiency models to understand the impact of local thyroid hormone regulator action on early development.

Gen Comp Endocrinol 2018 Sep 19. Epub 2018 Sep 19.

KU Leuven, Laboratory of Comparative Endocrinology, Department of Biology, B-3000 Leuven, Belgium. Electronic address:

Thyroid hormones (THs) stimulate and coordinate a wide range of processes to ensure normal development, mainly by binding of the most active TH 3,5,3'-triiodothyronine (T) to nuclear receptors resulting in changes in gene transcription. Local TH action is monitored at three distinct levels by different types of regulators: transmembrane transporters (TH influx and efflux), deiodinases (TH activation and inactivation) and nuclear receptors (TH signalling). Since TH regulators are strongly conserved among vertebrate species, the externally and rapidly developing zebrafish (Danio rerio) has become one of the favourite models to study their role in TH-dependent development. Read More

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http://dx.doi.org/10.1016/j.ygcen.2018.09.011DOI Listing
September 2018
4 Reads

Transgenerational thyroid endocrine disruption induced by bisphenol S affects the early development of zebrafish offspring.

Environ Pollut 2018 Dec 15;243(Pt B):800-808. Epub 2018 Sep 15.

Marine Life Science College, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong province, PR China.

Maternal thyroid hormones (THs) play an essential role in the embryonic and larval development of fish. Previous studies in fish have reported that parental exposure to thyroid disrupting chemicals (TDCs) changed maternal TH levels in the offspring; however, whether this transgenerational thyroid endocrine disruption can further disturb the early development of the offspring still remains largely unknown. Bisphenol S (BPS), a substitute of bisphenol A, has been reported to be a potential TDC. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.09.042DOI Listing
December 2018
2 Reads

Radioactive Iodine-Refractory Differentiated Thyroid Cancer in the Elderly.

Curr Oncol Rep 2018 Sep 11;20(10):82. Epub 2018 Sep 11.

Sylvester Comprehensive Cancer Center, University of Miami - Miller School of Medicine, Miami, FL, USA.

Most common thyroid cancers are differentiated thyroid cancers (DTCs) and have papillary, follicular, or Hürthle cell morphology. Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland. The incidence of DTC increases with age. Read More

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http://link.springer.com/10.1007/s11912-018-0736-4
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http://dx.doi.org/10.1007/s11912-018-0736-4DOI Listing
September 2018
18 Reads

Long-Term Late Toxicity, Quality of Life, and Emotional Distress in Patients With Nasopharyngeal Carcinoma Treated With Intensity Modulated Radiation Therapy.

Int J Radiat Oncol Biol Phys 2018 10 4;102(2):340-352. Epub 2018 Jun 4.

Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: To report long-term (>4 years) toxicity and quality of life (QoL) among patients with nasopharyngeal carcinoma (NPC) treated with intensity modulated radiation therapy (IMRT) in a nonendemic center.

Methods And Materials: A cross-sectional cohort study enrolled patients with NPC who were disease-free and ≥4 years after IMRT ± chemotherapy. Physician-reported adverse events (Common Terminology Criteria for Adverse Events, version 4. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.060DOI Listing
October 2018
24 Reads
4.260 Impact Factor

Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.

Endocr Rev 2019 02;40(1):17-65

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Immune checkpoints are small molecules expressed by immune cells that play critical roles in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) with inhibitory antibodies has demonstrated effective and durable antitumor activity in subgroups of patients with cancer. The US Food and Drug Administration has approved several immune checkpoint inhibitors (ICPis) for the treatment of a broad spectrum of malignancies. Read More

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http://dx.doi.org/10.1210/er.2018-00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270990PMC
February 2019
13 Reads

Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones: The Hokkaido birth cohort study.

Environ Res 2018 Nov 23;167:583-590. Epub 2018 Aug 23.

Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan. Electronic address:

Background: Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for thyroid hormones (TH) is limited, and the underlying mechanism remains unknown.

Objectives: We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and maternal and neonatal TH levels, taking the maternal-fetal TH transfer into account.

Methods: In this prospective birth cohort (the "Hokkaido study") we included 222 mother-neonate pairs. Read More

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http://dx.doi.org/10.1016/j.envres.2018.08.027DOI Listing
November 2018
4 Reads

Effects of environmentally relevant concentrations of tris (2-butoxyethyl) phosphate on growth and transcription of genes involved in the GH/IGF and HPT axes in zebrafish (Danio rerio).

Chemosphere 2018 Dec 20;212:376-384. Epub 2018 Aug 20.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tris (2-butoxyethyl) phosphate (TBOEP), as one of the most widely used organophosphate flame retardants (OPFRs), is applied in nearly all manufactured items and materials. It has been reported that TBOEP could cause developmental impairments and disrupt the endocrine regulation of fish growth during acute toxic experiments. However, concentrations to which fish were exposed in these studies were greater than environmentally relevant concentrations ever reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183157
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http://dx.doi.org/10.1016/j.chemosphere.2018.08.102DOI Listing
December 2018
15 Reads

Chronic effects of mercury on Bufo gargarizans larvae: Thyroid disruption, liver damage, oxidative stress and lipid metabolism disorder.

Ecotoxicol Environ Saf 2018 Nov 23;164:500-509. Epub 2018 Aug 23.

College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710119 China. Electronic address:

Mercury is severely detrimental to organisms and is ubiquitous in both terrestrial and aquatic ecosystems. In the present study, we examined the effects of chronic mercury (Hg) exposure on metamorphosis, body size, thyroid microstructures, liver microstructural and ultrastructural features, and transcript levels of genes associated with lipid metabolism, oxidative stress and thyroid hormones signaling pathways of Chinese toad (Bufo gargarizans) tadpoles. Tadpoles were exposed to mercury concentrations at 0, 6, 12, 18, 24 and 30 µg/L from Gosner stage 26-42 of metamorphic climax. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.08.058DOI Listing
November 2018
5 Reads

Anticonvulsant and Neuroprotective Effects of the Thyroid Hormone Metabolite 3-Iodothyroacetic Acid.

Thyroid 2018 Oct;28(10):1387-1397

1 Department of Neurology, Psychology, Drug Sciences, and Child Health, Pharmacology Division; Division of Clinical Pharmacology and Oncology; University of Florence , Florence, Italy .

Background: 3-Iodothyroacetic acid (TA1) is among the thyroid hormone (T3) metabolites that can acutely modify behavior in mice. This study aimed to investigate whether TA1 is also able to reduce neuron hyper-excitability and protect from excitotoxic damage.

Methods: CD1 male mice were treated intraperitoneally with saline solution or TA1 (4, 7, 11, or 33 μg/kg) before receiving 90 mg/kg pentylenetrazole subcutaneously. Read More

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http://dx.doi.org/10.1089/thy.2017.0506DOI Listing
October 2018
5 Reads

Changes in thyroid status of Menidia beryllina exposed to the antifouling booster irgarol: Impacts of temperature and salinity.

Chemosphere 2018 Oct 26;209:857-865. Epub 2018 Jun 26.

Department of Environmental Sciences, University of California Riverside, Riverside, CA, USA.

The triazine-based herbicide irgarol is widely used in antifouling systems as an algicide and has been detected recently in multiple coastal environments. Studies evaluating sub-lethal responses of fish following exposure to irgarol are limited. Moreover, impacts of climate change on fish endocrinology may also contribute to the sublethal toxicity of irgarol. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.06.152DOI Listing
October 2018
2 Reads

[Decabromodiphenyl ethane: a review of its pollution levels and toxicity].

Authors:
Y F Yu Y Bai T Chen

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Aug;52(8):855-861

School of Basic Medical Science, Capital Medicine University, Beijing 100069, China.

Decabromodiphenyl ethane (DBDPE) is a kind of new brominated flame retardants, which is widely used as a replace of decabromodiphenyl ether in electronic appliances, textiles and other goods. This review summarizes environmental levels and body burden of human beings of DBDPE in recent years. The data shows that the concentration of DBDPE in the environment and human tissues shows an upward trend. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.08.015DOI Listing

Effects of bisphenol analogs on thyroid endocrine system and possible interaction with 17β-estradiol using GH3 cells.

Toxicol In Vitro 2018 Dec 9;53:107-113. Epub 2018 Aug 9.

Department of Environmental Health, Graduate School at Yongin University, Yongin 17092, Republic of Korea. Electronic address:

This study was conducted using a rat pituitary (GH3) cell line to understand the effects of bisphenol analogs (BPs) on the thyroid endocrine system, in the presence of 17β-estradiol (E2). In the first series of experiments, changes in cell proliferation were examined after exposure to each of ten BPs, in the absence or presence of a median effective concentration (6.4 × 10 M) of triiodothyronine (T3). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183043
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http://dx.doi.org/10.1016/j.tiv.2018.08.005DOI Listing
December 2018
6 Reads