3,219 results match your criteria Toxicity Thyroid Hormone


Practical considerations for developmental thyroid toxicity assessments: What's working, what's not, and how can we do better?

Regul Toxicol Pharmacol 2019 Apr 21. Epub 2019 Apr 21.

BASF SE, Experimental Toxicology and Ecology, 67056, Ludwigshafen, Germany. Electronic address:

Thyroid hormones (THs; T3 and T4) play a role in development of cardiovascular, reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent studies (during pregnancy, in fetuses, neonates, and adults) is critical in hazard characterization and risk assessment. A roundtable session at the 2017 Society of Toxicology (SOT) meeting brought together academic, industry and government scientists to share knowledge and different perspectives on technical and data interpretation issues. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.04.010DOI Listing

Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits.

Environ Sci Pollut Res Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Zoology, University of the Punjab, Lahore, Pakistan.

Cadmium and mercury are non-biodegradable toxic metals that may cause many detrimental effects to the thyroid gland and blood. Vitamin C has been found to be a significant chain-breaking antioxidant and enzyme co-factor against metal toxicity and thus make them less available for animals. The current study was performed to find the effect of individual metals (cadmium and mercury), their co-administration, and the ameliorative effects of vitamin C on some of the parameters that indicate oxidative stress and thyroid dysfunction. Read More

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http://dx.doi.org/10.1007/s11356-019-04886-9DOI Listing
April 2019
1 Read

Parental exposure to 2,2',4,4'5 - pentain polybrominated diphenyl ethers (BDE-99) causes thyroid disruption and developmental toxicity in zebrafish.

Toxicol Appl Pharmacol 2019 Apr 10;372:11-18. Epub 2019 Apr 10.

Observation Station for Fishery Resource and Environment in Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Key Laboratory of Freshwater Biodiversity Conservation (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address:

Although polybrominated diphenyl ethers (PBDEs) are known to disturb thyroid hormone signaling, the mechanisms underlying the effects of 2,2',4,4'5 - pentain polybrominated diphenyl ethers (BDE-99) in fish remain unclear. In order to reveal these mechanisms, adult zebrafish (Danio rerio) were exposed to different concentrations of BDE-99 (0, 0.5, 5, or 50 μg/L) for 28 days and spawned by mating naturally in clean water (without BDE-99). Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.008DOI Listing
April 2019
2 Reads

Parental exposure to tebuconazole causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring.

Aquat Toxicol 2019 Apr 3;211:116-123. Epub 2019 Apr 3.

Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou 310058, PR China.

Azole fungicides are one class of the most extensively applied current-use pesticides. Tebuconazole is a common azole fungicide that has been frequently detected in aquatic ecosystems, thus raising concerns about its ecological safety. However, adverse effects of tebuconazole remain largely unknown, especially with regard to endocrine function in aquatic organisms. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.04.002DOI Listing
April 2019
2 Reads
3.451 Impact Factor

Thyroxine, levothyroxine, and thyroxine complexed into cyclodextrin changed animal behavior, oxygen consumption, and photopic electroretinogram of Colossoma macropomum.

Fish Physiol Biochem 2019 Apr 2. Epub 2019 Apr 2.

Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, Dois Irmãos,, Recife, PE, 52171-900, Brazil.

The toxic effects of thyroxine (TF), levothyroxine (L-T), and thyroxine complexed into β-cyclodextrin (β-CD-T) on the biological parameters of tambaqui (Colossoma macropomum) were evaluated. The animals were exposed to a chronic toxicity test based on concentrations of influent (60 ng/L) for 2 months. Weight, total length, animal behavior, oxygen consumption, photopic electroretinogram (ERG), and the Flicker exam were evaluated. Read More

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http://dx.doi.org/10.1007/s10695-019-00630-9DOI Listing
April 2019
2 Reads

Effects of exposure to ethanolic extract from Achyrocline satureioides (Lam.) D.C. flowers on reproductive and developmental parameters in Wistar rats.

J Toxicol Environ Health A 2019 Apr 2:1-10. Epub 2019 Apr 2.

b Department of Morphology , Institute of Biosciences of Botucatu, UNESP -São Paulo State University Estadual Paulista , Botucatu , São Paulo State , Brazil.

Achyrocline satureioides (LAM) D.C. is a species plant used in folk medicine with several medicinal properties; however, few studies have focused on its potential adverse effects. Read More

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http://dx.doi.org/10.1080/15287394.2019.1593904DOI Listing
April 2019
2 Reads

Thyroid Hormone Disruptors Interfere with Molecular Pathways of Eye Development and Function in Zebrafish.

Int J Mol Sci 2019 Mar 27;20(7). Epub 2019 Mar 27.

Department of Veterinary Sciences, Veterinary Physiology and Biochemistry, Zebrafishlab, University of Antwerp, Universiteitsplein 1, 2160 Wilrijk, Belgium.

The effects of thyroid hormone disrupting chemicals (THDCs) on eye development of zebrafish were investigated. We expected THDC exposure to cause transcriptional changes of vision-related genes, which find their phenotypic anchoring in eye malformations and dysfunction, as observed in our previous studies. Zebrafish were exposed from 0 to 5 days post fertilization (dpf) to either propylthiouracil (PTU), a thyroid hormone synthesis inhibitor, or tetrabromobisphenol-A (TBBPA), which interacts with thyroid hormone receptors. Read More

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http://dx.doi.org/10.3390/ijms20071543DOI Listing

Report from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points.

Arch Toxicol 2019 Mar 30. Epub 2019 Mar 30.

German Federal Institute for Risk Assessment, Berlin, Germany.

This publication summarizes discussions that were held during an international expert hearing organized by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany, in October 2017. The expert hearing was dedicated to providing practical guidance for the measurement of circulating hormones in regulatory toxicology studies. Adequate measurements of circulating hormones have become more important given the regulatory requirement to assess the potential for endocrine disrupting properties for all substances covered by the plant protection products and biocidal products regulations in the European Union (EU). Read More

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http://dx.doi.org/10.1007/s00204-019-02436-3DOI Listing
March 2019
2 Reads

Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats.

Environ Health Perspect 2019 Mar;127(3):37008

1 Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development (ORD), U.S. Environmental Protection Agency (U.S. EPA) , Research Triangle Park, North Carolina, USA.

Background: Hexafluoropropylene oxide dimer acid [(HFPO-DA), GenX] is a member of the per- and polyfluoroalkyl substances (PFAS) chemical class, and elevated levels of HFPO-DA have been detected in surface water, air, and treated drinking water in the United States and Europe.

Objectives: We aimed to characterize the potential maternal and postnatal toxicities of oral HFPO-DA in rats during sexual differentiation. Given that some PFAS activate peroxisome proliferator-activated receptors (PPARs), we sought to assess whether HFPO-DA affects androgen-dependent development or interferes with estrogen, androgen, or glucocorticoid receptor activity. Read More

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http://dx.doi.org/10.1289/EHP4372DOI Listing
March 2019
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Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors.

Eur J Med Chem 2019 May 8;170:1-15. Epub 2019 Mar 8.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:

Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in most cancer cells and it is increasingly recognized as a potential therapeutic target in oncology. In a continuation of our discovery of lead compound 5 and SAR study, the 7-azaindole moiety in compound 5 was systematically optimized. The results showed that compound 6f, which has a difluoroethyl substitution on the 7-azaindole ring, exhibited high PKM2 activation potency and anti-proliferation activities on A375 cell lines. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.003DOI Listing
May 2019
2 Reads

A transient window of hypothyroidism alters neural progenitor cells and results in abnormal brain development.

Sci Rep 2019 Mar 15;9(1):4662. Epub 2019 Mar 15.

U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Toxicity Assessment Division, Endocrine Toxicology Branch, Research Triangle Park, North Carolina, NC, 27711, USA.

Cortical heterotopias are clusters of ectopic neurons in the brain and are associated with neurodevelopmental disorders like epilepsy and learning disabilities. We have previously characterized the robust penetrance of a heterotopia in a rat model, induced by thyroid hormone (TH) disruption during gestation. However, the specific mechanism by which maternal TH insufficiency results in this birth defect remains unknown. Read More

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http://dx.doi.org/10.1038/s41598-019-40249-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420655PMC
March 2019
1 Read

Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations.

Ecotoxicol Environ Saf 2019 Jun 5;174:353-362. Epub 2019 Mar 5.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

The liver is one of the major targets of hormones, including thyroid hormones (THs), and many industrial chemicals, such as endocrine-disrupting chemicals. Those compounds may permeate the placenta barrier and pose a risk for embryonic development. Therefore, it is necessary to assess the toxic effects of those kind of industrial chemicals during liver development. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.091DOI Listing
June 2019
1 Read

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition.

Environ Int 2019 May 28;126:377-386. Epub 2019 Feb 28.

Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. Electronic address:

In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH) pathway. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.024DOI Listing
May 2019
1 Read

Toxicokinetics of Imidacloprid-Coated Wheat Seeds in Japanese Quail ( Coturnix japonica) and an Evaluation of Hazard.

Environ Sci Technol 2019 Apr 13;53(7):3888-3897. Epub 2019 Mar 13.

U.S. Geological Survey Patuxent, Wildlife Research Center , Beltsville , Maryland 20705 , United States.

Birds are potentially exposed to neonicotinoid insecticides by ingestion of coated seeds during crop planting. Adult male Japanese quail were orally dosed with wheat seeds coated with an imidacloprid (IMI) formulation at either 0.9 or 2. Read More

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http://dx.doi.org/10.1021/acs.est.8b07062DOI Listing
April 2019
2 Reads

Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish.

Sci Total Environ 2019 May 13;665:855-863. Epub 2019 Feb 13.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Although 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), an alternative to perfluorooctanesulfonate (PFOS), has been regularly detected in different environmental matrices, information regarding its toxicity remains limited. To explore the transgenerational thyroid-disrupting capacity of F-53B, adult zebrafish (F0) were exposed to different concentrations of F-53B (0, 5, 50, or 500μg/L) for 180d, with their offspring (F1 and F2) subsequently reared in uncontaminated water. Thyroid disturbances were then examined in the three (F0, F1, and F2) generations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.198DOI Listing
May 2019
1 Read

Proteome changes in methylmercury-exposed mouse primary cerebellar granule neurons and astrocytes.

Toxicol In Vitro 2019 Jun 15;57:96-104. Epub 2019 Feb 15.

Department of Biology, University of Ottawa, Canada. Electronic address:

Methylmercury (MeHg) is a neurotoxicant, with the cerebellum as the main target of toxicity; however, the toxic effects of MeHg on specific cell types remain unclear. Here, primary cerebellar granule neurons (CGNs) and cerebellar astrocytes were isolated and analyzed for total mercury accumulation, cellular reactive oxygen species (ROS) production, and whole-cell proteome expression after exposure to 0-10 μM MeHg for 24 h. Intracellular mercury and ROS levels showed dose-dependent increases. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.013DOI Listing
June 2019
1 Read

Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38/MAPK and MEK/ERK signal pathway.

Ecotoxicol Environ Saf 2019 May 13;173:142-148. Epub 2019 Feb 13.

Department of Geriatric Endocrinology, Geriatric Hospital of Nanjing Medical University, Luojia Road 30, Nanjing 210024, China. Electronic address:

Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.024DOI Listing
May 2019
1 Read

Parental exposure to tris(1,3-dichloro-2-propyl) phosphate results in thyroid endocrine disruption and inhibition of growth in zebrafish offspring.

Aquat Toxicol 2019 Apr 7;209:132-141. Epub 2019 Feb 7.

Key Laboratory of Preparation and Application of Environmental Friendly Materials, the Ministry of Education, Jilin Normal University, Siping, 136000, China.

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a re-emerging environmental contaminant used as a suitable substitute for brominated flame retardants. The objective of this study was to evaluate the effects of TDCIPP on thyroid disruption and growth inhibition in zebrafish (Danio rerio) offspring after chronic parental exposure, and to examine the possible molecular mechanisms involved. When adult zebrafish (4 months old) were exposed to 5. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.004DOI Listing
April 2019
2 Reads

Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio).

Aquat Toxicol 2019 Apr 28;209:99-112. Epub 2019 Jan 28.

University of Exeter, Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, Stocker Rd., Exeter, EX4 4QD, UK. Electronic address:

Brominated flame retardants are known to disrupt thyroid hormone (TH) homeostasis in several vertebrate species, but the molecular mechanisms underlying this process and their effects on TH-sensitive tissues during the stages of early development are not well characterised. In this study, we exposed zebrafish (Danio rerio) embryo-larvae to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and tetrabromobisphenol A (TBBPA) via the water for 96 h from fertilisation and assessed for lethality, effects on development and on the expression of a suite of genes in the hypothalamic-pituitary-thyroid (HPT) axis via both real time quantitative PCR (qRT-PCR) on whole body extracts and whole mount in situ hybridisation (WISH) to identify tissue targets. The 96-h lethal median concentration (96h-LC) for TBBPA was 0. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.01.022DOI Listing
April 2019
1 Read

Toxicity of Pexacerfont, a Corticotropin-Releasing Factor Type 1 Receptor Antagonist, in Rats and Dogs.

Int J Toxicol 2019 Mar/Apr;38(2):110-120. Epub 2019 Feb 13.

2 Evansville, IL, USA.

Pexacerfont is a corticotropin-releasing factor subtype 1 receptor antagonist that was developed for the treatment of anxiety- and stress-related disorders. This report describes the results of repeat-dose oral toxicity studies in rats (3 and 6 months) and dogs (3 months and 1 year). Pexacerfont was well tolerated in all of these studies at exposures equal to or greater than areas under the curve in humans (clinical dose of 100 mg). Read More

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http://dx.doi.org/10.1177/1091581819827501DOI Listing
February 2019
2 Reads

Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor.

Sci Total Environ 2019 Feb 5;653:1140-1148. Epub 2018 Nov 5.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

Acetochlor (ACT) is a chiral chloroacetamide pesticide that has been heavily used around the world, resulting in its residues being frequently found in surface waters. It has been reported that ACT is an endocrine disrupting chemical (EDC) with strong thyroid hormone-disrupting activity in aquatic organisms. However, the enantioselectivity underlying thyroid disruption has yet to be understood. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.037DOI Listing
February 2019
2 Reads

The organophosphate pesticide -OP- malathion inducing thyroidal disruptions and failures in the metamorphosis of the Senegalese sole, Solea senegalensis.

BMC Vet Res 2019 Feb 11;15(1):57. Epub 2019 Feb 11.

Instituto de Ciencias Marinas de Andalucía-ICMAN, CSIC Campus Universitario Río San Pedro, 11510, Puerto Real, Cádiz, Spain.

Background: Organophosphate pesticides-OP-, like malathion, can alter the normal functioning of neuro-endocrine systems (e.g., hypothalamus-pituitary-thyroid-HPT- axis), and to interfere on the thyroidal homeostasis. Read More

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http://dx.doi.org/10.1186/s12917-019-1786-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371575PMC
February 2019
1 Read

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Food Chem Toxicol 2019 Apr 5;126:1-6. Epub 2019 Feb 5.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422739PMC
April 2019
2 Reads

Acrylamide: A review about its toxic effects in the light of Developmental Origin of Health and Disease (DOHaD) concept.

Food Chem 2019 Jun 17;283:422-430. Epub 2019 Jan 17.

Laboratory of Reproductive Toxicology, Department of Pharmacy, State University of Centro-Oeste, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil. Electronic address:

The endocrine system is highly sensitive to endocrine-disrupting chemicals (EDC) which interfere with metabolism, growth and reproduction throughout different periods of life, especially in the embryonic and pubertal stages, in which gene reprogramming may be associated with impaired development and control of tissues/organs even in adulthood. Acrylamide is considered a potential EDC and its main source comes from fried, baked and roasted foods that are widely consumed by children, teenagers and adults around the world. This review aimed to present some aspects regarding the acrylamide formation, its toxicokinetics, the occurrence of acrylamide in foods, the recent findings about its effects on different systems and the consequences for the human healthy. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.01.054DOI Listing
June 2019
3 Reads

Transgenerational endocrine disruption: Does elemental pollution affect egg or nestling thyroid hormone levels in a wild songbird?

Environ Pollut 2019 Apr 23;247:725-735. Epub 2019 Jan 23.

Department of Biology, University of Turku, 20014, Turku, Finland.

Endocrine disrupting chemicals (EDCs) include a wide array of pollutants, such as some metals and other toxic elements, which may cause changes in hormonal homeostasis. In addition to affecting physiology of individuals directly, EDCs may alter the transfer of maternal hormones to offspring, i.e. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.088DOI Listing
April 2019
1 Read

Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring.

Environ Toxicol Pharmacol 2019 Apr 25;67:53-60. Epub 2019 Jan 25.

Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China. Electronic address:

Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of perinatal DEHP exposure on the thyroid function of pups. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.012DOI Listing
April 2019
1 Read

Cytotoxicity against fish and mammalian cell lines and endocrine activity of the mycotoxins beauvericin, deoxynivalenol and ochratoxin-A.

Food Chem Toxicol 2019 May 1;127:288-297. Epub 2019 Feb 1.

Department of Environment and Agronomy, National Institute for Agricultural and Food Research and Technology (INIA), Carretera de la Coruña km 7, 28040, Madrid, Spain. Electronic address:

The toxicity of mycotoxins is well recognized in mammals, but their effects on fish have received less attention. Moreover, in the last years several studies have reported that some mycotoxins may act as endocrine disruptors. The aim of this study was to determine the cytotoxic effects and endocrine activities of three mycotoxins: beauvericin, deoxynivalenol and ochratoxin-A. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.036DOI Listing
May 2019
4 Reads

Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats.

Environ Sci Pollut Res Int 2019 Mar 29;26(8):8202-8211. Epub 2019 Jan 29.

Department of Biological Sciences, Faculty of Science, College of Science, King Faisal University, Hofuf, Al-Ahsa, 31982, Saudi Arabia.

The aim of this study was to evaluate the probable protective effect of quercetin (QUE) against cadmium (Cd)-induced sub-chronic toxicity in rats. Adult male rats were given either Cd (as cadmium chloride; 5 mg/kg) alone or in combination with QUE (50 mg/kg) daily for 4 weeks by oral gavage. At the end of the experimental period, Cd accumulation, and selected hematological, thyroid, and reproductive markers were assessed. Read More

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http://link.springer.com/10.1007/s11356-019-04276-1
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http://dx.doi.org/10.1007/s11356-019-04276-1DOI Listing
March 2019
13 Reads
2.828 Impact Factor

Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae.

Metallomics 2019 Mar;11(3):621-631

Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada.

Mercury is one of the most toxic elements threatening the biosphere, with levels steadily rising due to both natural and human activities. Selenium is an essential micronutrient, required for normal development and functioning of many organisms. While selenium is known to counteract mercury's toxicity under some conditions, to date information about the mercury-selenium relationship is fragmented and often controversial. Read More

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http://xlink.rsc.org/?DOI=C8MT00315G
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http://dx.doi.org/10.1039/c8mt00315gDOI Listing
March 2019
21 Reads

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.

Pharm Biol 2019 Dec;57(1):29-37

a Key Laborotory Experimental Marine Biology, Institute of Oceanology , Chinese Academy of Sciences , Qingdao , China.

Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system.

Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Read More

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http://dx.doi.org/10.1080/13880209.2018.1563621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346718PMC
December 2019
3 Reads

Prevention & control of fluorosis & linked disorders: Developments in the 21 Century - Reaching out to patients in the community & hospital settings for recovery.

Indian J Med Res 2018 Nov;148(5):539-547

Centre for Promotion of Nutrition Research and Training with special focus on North East, tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

The review on fluorosis addresses the genesis of the disease, diagnostic protocols developed, mitigation and recovery through nutritional interventions. It reveals the structural and functional damages caused to skeletal muscle and erythrocytes, leading to clinical manifestations in fluorosis. Hormonal derangements resulting in serious abnormalities in the health of children and adults are discussed. Read More

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http://www.ijmr.org.in/text.asp?2018/148/5/539/249979
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http://dx.doi.org/10.4103/ijmr.IJMR_1775_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366265PMC
November 2018
17 Reads

Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.

J Med Chem 2019 Feb 4;62(4):1837-1858. Epub 2019 Feb 4.

New Drug Development Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , South Korea.

An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to radioiodine therapy in vitro. We synthesized potent, selective, and orally bioavailable ERRγ-inverse agonists and evaluated their activity by analyzing in vitro pharmacology and absorption, distribution, metabolism, excretion, and toxicity profiles. X-ray crystallographic analysis of the ligand and ERRγ complex showed that 35 completely binds to the target protein (PDB 6A6K ). Read More

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01296
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http://dx.doi.org/10.1021/acs.jmedchem.8b01296DOI Listing
February 2019
12 Reads

Organophosphate Ester, 2-Ethylhexyl Diphenyl Phosphate (EHDPP), Elicits Cytotoxic and Transcriptomic Effects in Chicken Embryonic Hepatocytes and Its Biotransformation Profile Compared to Humans.

Environ Sci Technol 2019 Feb 1;53(4):2151-2160. Epub 2019 Feb 1.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.

The effects of 2-ethylhexyl diphenyl phosphate (EHDPP) on cytotoxicity and mRNA expression, as well as its metabolism, were investigated using a chicken embryonic hepatocyte (CEH) assay. After incubation for 36 h, the lethal concentration 50 (LC) was 50 ± 11 μM, suggesting that EHDPP is one of a small cohort of highly toxic organophosphate esters (OPEs). By use of a ToxChip polymerase chain reaction (PCR) array, we report modulation of 6, 11, or 16/43 genes in CEH following exposure to 0. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.8b06246
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http://dx.doi.org/10.1021/acs.est.8b06246DOI Listing
February 2019
10 Reads

Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study.

Mol Autism 2019 9;10. Epub 2019 Jan 9.

1Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.

Background: Evidence has indicated that some non-inherited factors such as exposure to environmental pollutants are associated with neurodevelopment disorders like autism spectrum disorder (ASD). Studies report that endocrine disrupting compounds (EDCs), including polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances (PFAS), and some metals, have adverse effects on the fetal neurodevelopment. The aim of this study was to measure the amniotic fluid (AF) levels of EDCs and metals as well as the receptor transactivities induced by AF and investigate the possible link between prenatal exposure to EDCs and heavy metals and ASD risk. Read More

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https://molecularautism.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13229-018-0253-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327542PMC
February 2019
12 Reads

Amphibian (Rana nigromaculata)exposed to cyproconazole: Changes in growth index, behavioral endpoints, antioxidant biomarkers, thyroid and gonad development.

Aquat Toxicol 2019 Mar 3;208:62-70. Epub 2019 Jan 3.

Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing, 100193, China. Electronic address:

Pesticides are a major cause of reduction in the global population of amphibians. This study investigates the effect of varying concentrations of cyproconazole (1 and 10 mg/L) on Rana nigromaculata during a chronic 90 days exposure period. High levels of cyproconazole (10 mg/L) induced declined body weight, short snout-vent length, slow metamorphic development and abnormal behavioral endpoints in R. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183092
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http://dx.doi.org/10.1016/j.aquatox.2018.12.015DOI Listing
March 2019
15 Reads
3.451 Impact Factor

Enantioselectivity in endocrine disrupting effects of four cypermethrin enantiomers based on in vitro models.

Chemosphere 2019 Apr 28;220:766-773. Epub 2018 Dec 28.

College of Environment, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address:

Cypermethrin (CP) is a kind of chiral pesticides that has been defined as endocrine disrupting chemical. The diversity in bioactivity, toxicity, metabolism, bioaccumulation, and degradation behaviors of CP enantiomers as well as the research deficiency had made the risk assessment of CP enantiomers very complicated. Herein, four CP enantiomers were separated as target chemicals to investigate their enantioselective endocrine disrupting effects. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.158DOI Listing

Insecticide pyriproxyfen (Dragón) damage biotransformation, thyroid hormones, heart rate, and swimming performance of Odontophrynus americanus tadpoles.

Chemosphere 2019 Apr 2;220:714-722. Epub 2019 Jan 2.

Ecotoxicology Laboratory, Faculty of Biochemistry and Biological Sciences, FBCB-UNL, Ciudad Universitaria, Paraje el Pozo s/n (3000), Santa Fe, Argentina. Electronic address:

Odontoprynus americanus tadpoles were used to determine the safety concentration of pyriproxyfen (PPF) insecticide by acute and sublethal toxicity tests (nominal range tested 0.01 to 10 [± 15%] PPF mg/L). Median lethal concentration (LC) and no, and lowest-observed-effect concentrations (NOEC and LOEC, respectively) were calculated. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.181DOI Listing
April 2019
2 Reads

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules.

Chemosphere 2019 Mar 17;218:885-894. Epub 2018 Nov 17.

Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131, Naples, Italy; Consorzio Interuniversitario INBB, Viale Medaglie d'Oro, 305, I-00136, Rome, Italy. Electronic address:

Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of environmental pollution, most of which exerting endocrine-disrupting activity, in thyroid cancer development. The increasing incidence of differentiated thyroid cancer (DTC) may be related to the rising production and environmental dissemination of pollutants. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.084DOI Listing
March 2019
4 Reads

Is the current-use flame retardant, DBE-DBCH, a potential obesogen? Effects on body mass, fat content and associated behaviors in American kestrels.

Ecotoxicol Environ Saf 2019 Mar 29;169:770-777. Epub 2018 Nov 29.

Ecotoxicology & Wildlife Health Division, Science & Technology Branch, Environment and Climate Change Canada, Burlington, Ontario, Canada. Electronic address:

The current-use brominated flame retardant, 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (DBE-DBCH), is capable of perturbing sex steroid and thyroid hormone pathways in vitro and in vivo. Chemicals with this capability may also disrupt metabolic processes and are candidate obesogens, but this potential has not yet been determined for DBE-DBCH. Our objective was to examine gross biomarkers of metabolic disruption in captive American kestrels. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.104DOI Listing
March 2019
1 Read

Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring.

Life Sci 2019 Feb 23;218:253-264. Epub 2018 Dec 23.

Laboratory of Endocrine Physiology, Biology Institute, State University of Rio de Janeiro, RJ, Brazil. Electronic address:

Aims: Bisphenol A (BPA), an endocrine disruptor used in industrial applications, has been detected in both placenta and milk. We studied the effects of BPA exposure during pregnancy and lactation on body composition, palatable food intake, biochemical, hormonal and behavioral profiles of young and adult Wistar rat offspring.

Main Methods: Female rats were divided into: control, BPA10 (10 μg/kg/day) and BPA50 (50 μg/kg/day). Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.039DOI Listing
February 2019

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases.

Toxicol Sci 2019 Apr;168(2):430-442

U.S. Environmental Protection Agency.

Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical inhibition of deiodinase activity has been identified as an important endpoint to include in screening chemicals for thyroid hormone disruption. To address the lack of data regarding chemicals that inhibit the deiodinase enzymes, we developed robust in vitro assays that utilized human deiodinase types 1, 2, and 3 and screened over 1800 unique chemicals from the U. Read More

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http://dx.doi.org/10.1093/toxsci/kfy302DOI Listing
April 2019
2 Reads

Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development.

Chemosphere 2019 Mar 8;219:517-525. Epub 2018 Dec 8.

Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Hangzhou, 310021, Zhejiang, China. Electronic address:

Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.061DOI Listing
March 2019
5 Reads

Lithium Treatment Is Safe in Children With Intellectual Disability.

Front Mol Neurosci 2018 22;11:425. Epub 2018 Nov 22.

Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lithium is a widely used and effective treatment for individuals with psycho-neurological disorders, and it exhibits protective and regenerative properties in multiple brain injury animal models, but the clinical experience in young children is limited due to potential toxicity. As an interim analysis, this paper reports the safety/tolerability profiles of low-dose lithium treatment in children with intellectual disability (ID) and its possible beneficial effects. In a randomized, single-center clinical trial, 124 children with ID were given either oral lithium carbonate 6 mg/kg twice per day or the same dose of calcium carbonate as a placebo ( = 62/group) for 3 months. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00425
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http://dx.doi.org/10.3389/fnmol.2018.00425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262083PMC
November 2018
23 Reads

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

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http://dx.doi.org/10.26355/eurrev_201811_16434DOI Listing
November 2018
4 Reads

Octylphenol influence growth and development of Rana chensinensis tadpoles via disrupting thyroid function.

Ecotoxicol Environ Saf 2019 Mar 28;169:747-755. Epub 2018 Nov 28.

College of Life Sciences, Shaanxi Normal University, Xi'an 710119, Shaanxi, PR China. Electronic address:

Octylphenol (OP), a class of endocrine disrupting chemicals (EDCs), could produce adverse effects on developmental process of animals. Thyroid hormone is one of the important hormones involved in animal development. To determine whether OP affect the growth and development of amphibian larvae via interfering the thyroid function, Rana chensinensis larvae at Gosner stage 29 were exposed to 10, 10 and 10 mol/L OP in the present study. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.083DOI Listing
March 2019
4 Reads
2.762 Impact Factor

Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish.

Ecotoxicol Environ Saf 2019 Apr 1;170:25-32. Epub 2018 Dec 1.

School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Organophosphate flame retardants (OPFRs) have been widely used as alternatives to polybrominated diphenyl ethers for fire prevention. OPFRs are suspected of causing potential thyroid disruption in humans. In fish, their thyroid hormone modulation is reported but the mechanisms of this modulation are less understood. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.058DOI Listing
April 2019
4 Reads

Gonadal impairment and parental transfer of tris (2-butoxyethyl) phosphate in zebrafish after long-term exposure to environmentally relevant concentrations.

Chemosphere 2019 Mar 22;218:449-457. Epub 2018 Nov 22.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tris (2-butoxyethyl) phosphate (TBOEP) is a ubiquitous environmental contaminant due to its overuse. TBOEP has been found to cause reproductive toxicity and endocrine disruption during acute toxic experiment. In this study, we examined the effects of TBOEP on growth in initial generation (F0) zebrafish and transgenerational effects on growth of first generation (F1) larvae after parental long-term exposure (120 d) to environmentally relevant concentrations (0, 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.139DOI Listing
March 2019
3 Reads

European Perspective on 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: Proceedings of an Interactive International Symposium.

Thyroid 2019 Jan 7;29(1):7-26. Epub 2019 Jan 7.

18 Department of Endocrinology and Metabolism, Endocrine Tumor Center at WTZ, Essen University Hospital, Essen, Germany.

Background: The American Thyroid Association (ATA) management guidelines for patients with thyroid nodules and differentiated thyroid cancer (DTC) are highly influential practice recommendations. The latest revision appeared in 2015 ("ATA 2015"). These guidelines were developed predominantly by North American experts. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2017.0129
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http://dx.doi.org/10.1089/thy.2017.0129DOI Listing
January 2019
7 Reads

Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin αvβ3.

J Environ Sci (China) 2019 Jan 24;75:1-13. Epub 2018 May 24.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Bisphenol A (BPA) is one of the highest volume industrial products worldwide and has been widely used to make various products as the intermediates of polycarbonate plastics and epoxy resins. Inevitably, general population has been widely exposed to BPA due to extensive use of BPA-containing products. BPA has similar chemical structure with the natural estrogen and has been shown to induce a variety of estrogen-like endocrine effects on organism in vivo or in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10010742173349
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http://dx.doi.org/10.1016/j.jes.2018.05.002DOI Listing
January 2019
8 Reads
2.002 Impact Factor

Endocrine and metabolic adverse effects of immune checkpoint inhibitors: an overview (what endocrinologists should know).

J Endocrinol Invest 2018 Nov 23. Epub 2018 Nov 23.

Department of Human Pathology of Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy.

Immune checkpoint inhibitors (ICIs) are novel anticancer agents, recently introduced with the aim of boosting the immune response against tumors. ICIs are monoclonal autoantibodies that specifically target inhibitory receptors on T cells: cytotoxic T lymphocyte antigen 4 (CTLA4), programmed death 1 (PD-1) and its ligand (PD-1L). ICIs also generate peculiar dysimmune toxicities, called immune-related adverse events (irAEs), that can potentially affect any tissue, and some may be life-threatening if not promptly recognized. Read More

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http://dx.doi.org/10.1007/s40618-018-0984-zDOI Listing
November 2018
14 Reads