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    2728 results match your criteria Toxicity Thyroid Hormone

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    Alternative plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester, for blood containers with protective effects on red blood cells and improved cold resistance.
    J Biomed Mater Res B Appl Biomater 2017 May 13. Epub 2017 May 13.
    Division of Medical Devices, National Institute of Health Sciences, Tokyo, 158-8501, Japan.
    Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC-made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers. Read More

    IMPAIRED SWIM BLADDER INFLATION IN EARLY-LIFE STAGE FATHEAD MINNOWS EXPOSED TO A DEIODINASE INHIBITOR, IOPANOIC ACID.
    Environ Toxicol Chem 2017 May 10. Epub 2017 May 10.
    Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth,Minnesota.
    Inflation of the posterior and/or anterior swim bladder are processes previously demonstrated to be thyroid-hormone regulated. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically-active form, 3,5,3'-triiodothyronine (T3), would impact swim bladder inflation. Two experiments were conducted using a model deiodinase inhibitor, iopanoic acid (IOP). Read More

    Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.
    J Biol Chem 2017 May 1. Epub 2017 May 1.
    The University of Texas at Austin, United States;
    Manganese (Mn) is an essential metal that becomes toxic at elevated levels. Loss-of-function mutations in SLC30A10, a cell surface-localized Mn efflux transporter, cause a heritable Mn metabolism disorder resulting in elevated Mn levels and parkinsonian-like movement deficits. The underlying disease mechanisms are unclear; therefore, treatment is challenging. Read More

    Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications.
    Ann Pediatr Endocrinol Metab 2017 Mar 31;22(1):6-14. Epub 2017 Mar 31.
    School of Public Health, Seoul National University, Seoul, Korea.
    Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Read More

    Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes.
    PLoS One 2017 24;12(4):e0175784. Epub 2017 Apr 24.
    Type 1 Diabetes Centre, Infectivology and Clinical Trials Area, Children's Hospital Bambino Gesù, Rome, Italy.
    Type 1 diabetes and thyroid disease are T cell-dependent autoimmune endocrinopathies. The standard substitutive administration of the deficient hormones does not halt the autoimmune process; therefore, development of immunotherapies aiming to preserve the residual hormonal cells, is of crucial importance. PTPN22 C1858T mutation encoding for the R620W lymphoid tyrosine phosphatase variant, plays a potential pathophysiological role in autoimmunity. Read More

    Thyroid disrupting pesticides impair the hypothalamic-pituitary-testicular axis of a wildlife bird, Amandava amandava.
    Reprod Toxicol 2017 Apr 19;71:32-41. Epub 2017 Apr 19.
    Department of Biology, University of Waseda, Tokyo, Japan.
    The effect of two thyroid disrupting pesticides (TDPs) mancozeb (MCZ) and imidacloprid (IMI) on the hypothalamic-pituitary-gonadal/testicular (HPG) axis of a seasonally breeding bird, Amandava amandava has been evaluated. Male birds (n=8/group) were exposed to each of the pesticide (0.25% LD50 of respective pesticide) as well as to their two equimixture doses (0. Read More

    Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.
    Toxicol Sci 2017 Apr 14. Epub 2017 Apr 14.
    current affiliation: Health Research Institute Laboratories, Fairfield, Iowa. USA.
    Chiral polychlorinated biphenyl (PCB) congeners have been implicated by laboratory and epidemiological studies in PCB developmental neurotoxicity. These congeners are metabolized by cytochrome P450 (P450) enzymes to potentially neurotoxic hydroxylated metabolites (OH-PCBs). The present study explores the enantioselective disposition and toxicity of two environmentally relevant, neurotoxic PCB congeners and their OH-PCB metabolites in lactating mice and their offspring following dietary exposure of the dam. Read More

    Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma.
    Cochrane Database Syst Rev 2017 Apr 21;4:CD010349. Epub 2017 Apr 21.
    Nuclear Medicine, Academic Medical Center, P.O Box 9, Amsterdam, Netherlands, 2200 DD.
    Background: Patients with newly diagnosed high-risk (HR) neuroblastoma (NBL) still have a poor outcome, despite multi-modality intensive therapy. This poor outcome necessitates the search for new therapies, such as treatment with (131)I-meta-iodobenzylguanidine ((131)I-MIBG).

    Objectives: To assess the efficacy and adverse effects of (131)I-MIBG therapy in patients with newly diagnosed HR NBL. Read More

    Clinical Toxicity of Acute Overdoses With L-Thyroxin in Children.
    Pediatr Emerg Care 2017 Apr 18. Epub 2017 Apr 18.
    From the *Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri; and †Department of Pediatric Endocrinology, Dr Sami Ulus Children Training and Research Hospital, Ankara, Turkey.
    Objectives: L-Thyroxine ingestion is rarely seen in children; here, we report our experience of it. This study describes the clinical characteristics and laboratory findings of acute L-thyroxine ingestion in children.

    Methods: This retrospective study enrolled patients treated for L-thyroxine ingestion at Kayseri Teaching Hospital between September 2013 and September 2016. Read More

    Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury.
    J Neural Eng 2017 Jun 30;14(3):036014. Epub 2017 Mar 30.
    School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United States of America.
    Objective: Traumatic spinal cord injury (SCI) causes apoptosis of myelin-forming oligodendrocytes (OLs) and demyelination of surviving axons, resulting in conduction failure. Remyelination of surviving denuded axons provides a promising therapeutic target for spinal cord repair. While cell transplantation has demonstrated efficacy in promoting remyelination and functional recovery, the lack of ideal cell sources presents a major obstacle to clinical application. Read More

    Recognizing and managing on toxicities in cancer immunotherapy.
    Tumour Biol 2017 Mar;39(3):1010428317694542
    Department of Cancer Biotherapy Center, Hubei Cancer Hospital, Wuhan, China.
    Over the past 4 years, cancer immunotherapy has significantly prolonged survival time of patients with prostate cancer, melanoma, lung cancer, and liver cancer, but its side effects are also impressive. Different types of the immune therapeutic agents have different on-target or off-target toxicity due to high affinity or weak specificity, respectively. Treatment toxicity spectrums vary greatly even in patients with the same type of cancer. Read More

    Impact of body mass index on survival outcome in patients with differentiated thyroid cancer.
    Braz J Otorhinolaryngol 2017 Feb 28. Epub 2017 Feb 28.
    King Saud University, College of Medicine, Department of Otolaryngology-Head & Neck Surgery, Riyadh, Saudi Arabia. Electronic address:
    Introduction: Increased body mass index (BMI) is known to be associated with the high prevalence of Differentiated Thyroid Cancers (DTC); however data on its impact on survival outcome after thyroidectomy and adjuvant therapy is scanty.

    Objective: We aimed to evaluate the impact of BMI on overall survival (OS) and disease free survival (DFS) rates in patients with DTC.

    Methods: Between 2000 and 2011, 209 patients with DTC (papillary, follicular, hurthle cell) were treated with thyroidectomy followed by adjuvant radioactive iodine-131 (RAI) therapy and thyroid-stimulating hormone (TSH) suppression. Read More

    Safety and tolerability of a dried aqueous spearmint extract.
    Regul Toxicol Pharmacol 2017 Jun 7;86:167-176. Epub 2017 Mar 7.
    Kemin Foods, L.C., 2100 Maury St., Des Moines, IA 50317, USA.
    Spearmint (Mentha spicata L.) and spearmint extracts are Generally Recognized as Safe (GRAS) for use as flavoring in beverages, pharmaceuticals, and confectionaries. Studies of spearmint extracts in humans and animals have reported conflicting results with respect to toxicity. Read More

    Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga.
    Fish Physiol Biochem 2017 Mar 11. Epub 2017 Mar 11.
    Laboratory of Fish Reproduction, Aquaculture Division, National Institute of Oceanography Fisheries, Alexandria, 21556, Egypt.
    Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (Cydonia oblonga). To fulfill this aim, catfish Clarias gariepinus were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. Read More

    Semicarbazide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus) and its potential mechanisms.
    Ecotoxicol Environ Saf 2017 Jun 28;140:131-140. Epub 2017 Feb 28.
    Marine Life Science College, Ocean University of China, Qingdao 266003, China. Electronic address:
    Semicarbazide (SMC) is a carcinogenic and genotoxic substance that has been found in aquatic systems. SMC may also cause thyroid follicular epithelial cell injury in rats, but the thyroid-disrupting properties of SMC and its potential mechanisms remain unclear. In this study, we exposed fertilized eggs of Japanese flounder (Paralichthys olivaceus) to 1, 10, 100, and 1000μg/L SMC for 55 d to assess the impact of SMC exposure on the thyroid system. Read More

    Adverse effects of BDE-47 on in vivo developmental parameters, thyroid hormones, and expression of hypothalamus-pituitary-thyroid (HPT) axis genes in larvae of the self-fertilizing fish Kryptolebias marmoratus.
    Chemosphere 2017 Jun 20;176:39-46. Epub 2017 Feb 20.
    Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:
    2,2',4,4'-tetrabromodiphenylether (BDE-47) is known to have the potential to disrupt the thyroid endocrine system in fishes due to its structural similarity to the thyroid hormones triiodothyronine (T3) and thyroxine (T4). However, the effects of BDE-47 on thyroid function in fishes remain unclear. In this study, abnormal development (e. Read More

    Re-evaluation of thyroid hormone signaling antagonism of tetrabromobisphenol A for validating the T3-induced Xenopus metamorphosis assay.
    J Environ Sci (China) 2017 Feb 24;52:325-332. Epub 2016 Nov 24.
    College of Environment, Nanjing University of Technology, Nanjing 211816, China. Electronic address:
    We developed the T3-induced Xenopus metamorphosis assay, which is supposed to be able to sensitively detect thyroid hormone (TH) signaling disruption of chemicals. The present study aimed to validate the T3-induced Xenopus metamorphosis assay by re-evaluating the TH signaling antagonism of tetrabromobisphenol A (TBBPA), a known TH signaling disruptor. According to the assay we developed, Xenopus tadpoles at stage 52 were exposed to 10-500nmol/L TBBPA in the presence of 1nmol/L T3. Read More

    Optimization of the T3-induced Xenopus metamorphosis assay for detecting thyroid hormone signaling disruption of chemicals.
    J Environ Sci (China) 2017 Feb 23;52:314-324. Epub 2016 Nov 23.
    School of Environment and Resource, Southwest University of Science and Technology, Mianyang 621010, China. Electronic address:
    T3-induced Xenopus metamorphosis is an ideal model for detecting thyroid hormone (TH) signaling disruption of chemicals. To optimize the T3-induced Xenopus assay and improve its sensitivity and reproducibility, we intend to develop quantitatively morphological endpoints and choose appropriate concentrations and exposure durations for T3 induction. Xenopus laevis at stage 52 were exposed to series of concentrations of T3 (0. Read More

    Disruption of the hypothalamic-pituitary-thyroid axis on co-exposures to dithiocarbamate and neonicotinoid pesticides: Study in a wildlife bird, Amandava amandava.
    Neurotoxicology 2017 Feb 22;60:16-22. Epub 2017 Feb 22.
    Department of Zoology, University of Allahabad, Allahabad 211002, U.P., India. Electronic address:
    Non-target organisms, including human and wildlife, are susceptible to deleterious effects of pesticide mixtures in their environment. Present study demonstrated the disruption of the hypothalamic-pituitary-thyroid (HPT) axis in a seasonally breeding wildlife bird Amandava amandava on co-exposure to dithiocarbamate mancozeb/MCZ and neonicotinoid imidacloprid/IMI, at concentrations even lower than respective environmentally realistic exposure level of each of the pesticide. Adult male birds (n=8/group) were exposed individually to 0. Read More

    [Human exposure and thyroid toxicity of polybrominated diphenyl ethers].
    Zhonghua Yu Fang Yi Xue Za Zhi 2017 Feb;51(2):188-192
    School of Public Health, Shanghai Jiao Tong university, Shanghai 200025, China.
    Polybrominated diphenyl ethers (PBDEs), a kind of important Brominated Flame Retardant (BFR), are widely used in electronic products, construction materials and textiles. PBDEs have been detected in many environmental media (including air, water, dust, sediment and food), many animal and human tissues. For their environmental persistence, high bioaccumulative and multiple biotoxicitiies, PBDEs have been viewed as one of the most concerned environmental Endocrine Disrupting Chemicals (EDCs) at present. Read More

    Birds and flame retardants: A review of the toxic effects on birds of historical and novel flame retardants.
    Environ Res 2017 Apr 10;154:398-424. Epub 2017 Feb 10.
    Environment and Climate Change Canada, Canada Centre for Inland Waters, 867 Lakeshore Road, Burlington, Ontario, Canada L7S 1A1. Electronic address:
    Flame retardants (FRs) are a diverse group of chemicals, many of which persist in the environment and bioaccumulate in biota. Although some FRs have been withdrawn from manufacturing and commerce (e.g. Read More

    Disruption of thyroxine and sex hormones by 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (DBE-DBCH) in American kestrels (Falco sparverius) and associations with reproductive and behavioral changes.
    Environ Res 2017 Apr 9;154:389-397. Epub 2017 Feb 9.
    Ecotoxicology & Wildlife Health Division, Science & Technology Branch, Environment and Climate Change Canada, Burlington, Ontario, Canada. Electronic address:
    1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (DBE-DBCH - formerly TBECH) is an emerging brominated flame retardant (BFR) pollutant with androgen potentiating ability and other endocrine disrupting effects in birds and fish. The objectives of this study were to determine the effects of exposure to environmentally-relevant levels of DBE-DBCH on circulating levels of thyroid and sex steroid hormones in American kestrels, and if hormonal concentrations were related to previously reported changes in reproductive success and courtship behaviors. Sixteen kestrel pairs were exposed to 0. Read More

    Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus).
    Aquat Toxicol 2017 Apr 4;185:40-47. Epub 2017 Feb 4.
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing 100085, PR China.
    In the present study, to evaluate embryonic toxicity and the thyroid-disrupting effects of 2,4-dichloro-6-nitrophenol (DCNP), embryos and adults of Chinese rare minnow (Gobiocypris rarus) were exposed to 2, 20, and 200μg/L DCNP. In the embryo-larval assay, increased percentages of mortality and occurrence of malformations, decreased percentage of hatching, and decreased body length and body weight were observed after DCNP treatment. Moreover, the whole-body T3 levels were significantly increased at 20 and 200μg/L treatments, whereas the T4 levels were markedly decreased significantly (p<0. Read More

    Risk of cumulative toxicity after complete melanoma response with pembrolizumab.
    BMJ Case Rep 2017 Feb 1;2017. Epub 2017 Feb 1.
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Pembrolizumab is an approved first-line systemic therapy for unresectable metastatic melanoma. Despite the achievement of complete and durable responses in a small subgroup of patients, it is standard practice that pembrolizumab therapy continues beyond complete response. Nevertheless, the incidence of immune-related toxicities gradually increases with continuing pembrolizumab therapy. Read More

    Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats.
    Oxid Med Cell Longev 2017 4;2017:4383652. Epub 2017 Jan 4.
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
    Wistar rats were randomly divided into groups of varying iodide intake: normal iodide; 10 times high iodide; and 100 times high iodide on Days 7, 14, and 28. Insignificant changes were observed in thyroid hormone levels (p > 0.05). Read More

    Hypothesis-driven weight-of-evidence analysis of endocrine disruption potential: a case study with triclosan.
    Crit Rev Toxicol 2017 Apr 27;47(4):263-285. Epub 2017 Jan 27.
    b Colgate-Palmolive Company , Piscataway , NJ , USA.
    Triclosan is an antimicrobial agent used in a range of consumer products, such as deodorants, oral care, clothing, and household items. As with many consumer products, triclosan can be rinsed down the drain and transported to wastewater treatment plants. While most is eliminated during activated sludge sewage treatment by biodegradation and adsorption, some triclosan enters the aquatic environment and may expose wildlife. Read More

    An Overview of Selenium Uptake, Metabolism, and Toxicity in Plants.
    Front Plant Sci 2016 11;7:2074. Epub 2017 Jan 11.
    Ecotoxicogenomics Lab, Department of Biotechnology, Jamia Millia Islamia New Delhi, India.
    Selenium (Se) is an essential micronutrient for humans and animals, but lead to toxicity when taken in excessive amounts. Plants are the main source of dietary Se, but essentiality of Se for plants is still controversial. However, Se at low doses protects the plants from variety of abiotic stresses such as cold, drought, desiccation, and metal stress. Read More

    Endocrine disrupting pesticides impair the neuroendocrine regulation of reproductive behaviors and secondary sexual characters of red munia (Amandava amandava).
    Physiol Behav 2017 May 21;173:15-22. Epub 2017 Jan 21.
    Department of Zoology, University of Allahabad, Allahabad 211002, U.P., India. Electronic address:
    The exposure effects of two endocrine disrupting pesticides (EDPs), mancozeb/MCZ and imidacloprid/IMI of the group dithiocarbamate and neonicotinoid respectively, on reproductive behaviors and secondary sexual characters have been studied in a seasonally breeding wildlife bird, red munia (Amandava amandava). Adult male birds were exposed to both the pesticides individually (0.25% LD50 of each) as well as co-exposed (MIX-I: 0. Read More

    Thyroid pathology in deer mice (Peromyscus maniculata) from a reclaimed mine site on the athabasca oil sands.
    Environ Pollut 2017 Mar 16;222:42-49. Epub 2017 Jan 16.
    Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW Calgary, Alberta T2N 4Z6, Canada. Electronic address:
    Information on naturally occurring thyroid disease in wild animals in general and in small mammals specifically is extremely limited. In the present field-based work, we investigated the structure and function of thyroid glands of deer mice (Peromyscus maniculata) studied as sentinels of ecosystem sustainability on reclaimed areas post-mining on the oil sands of northeastern Alberta, because of their greater sensitivity to contaminants relative to meadow voles (Microtus pennsylvanicus) on the same sites. Extraction of bitumen in the oil sands of northeastern Alberta, results in the release of contaminants including polycyclic aromatic compounds (PACs), metals, and metalloids to the environment that have a measurable biological cost to wildlife living in the affected areas. Read More

    Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages.
    Chemosphere 2017 Apr 4;172:210-216. Epub 2017 Jan 4.
    Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing, 100085, China. Electronic address:
    Flufenoxuron is a widely used pesticide to inhibit the synthesis of chitin during insect development and its effect on the growth of lizards has been little addressed. The hypothalamus-pituitary-thyroid (HPT) axis plays an important role on the development of lizards. In this study, the lizards at different development stages (proliferation and resting stages) were exposed to flufenoxuron for 21 days. Read More

    Effects of Long-Term In Vivo Exposure to Di-2-Ethylhexylphthalate on Thyroid Hormones and the TSH/TSHR Signaling Pathways in Wistar Rats.
    Int J Environ Res Public Health 2017 Jan 4;14(1). Epub 2017 Jan 4.
    Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150081, China.
    Di-(2-ethylhexyl)phthalate (DEHP) was a widely used chemical with human toxicity. Recent in vivo and in vitro studies suggested that DEHP-exposure may be associated with altered serum thyroid hormones (THs) levels, but the underlying molecular mechanisms were largely unknown. To explore the possible molecular mechanisms, 128 Wistar rats were dosed with DEHP by gavage at 0, 150, 300, and 600 mg/kg/day for 3 months (M) and 6 M, respectively. Read More

    Adult hippocampal neurogenesis is impaired by transient and moderate developmental thyroid hormone disruption.
    Neurotoxicology 2017 Mar 31;59:9-21. Epub 2016 Dec 31.
    Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
    The hippocampus maintains a capacity for neurogenesis throughout life, a capacity that is reduced in models of adult onset hypothyroidism. The effects of developmental thyroid hormone (TH) insufficiency on neurogenesis in the adult hippocampus, however, has not been examined. Graded degrees of TH insufficiency were induced in pregnant rat dams by administration of 0, 3 or 10ppm of 6-propylthiouracil (PTU) in drinking water from gestational day (GD) 6 until weaning. Read More

    Arecoline aggravates hypothyroidism in metabolic stress in mice.
    Arch Physiol Biochem 2017 May 26;123(2):105-111. Epub 2016 Dec 26.
    a Department of Zoology , University of Calcutta , Calcutta , India.
    Millions of people consume betel nut for increased capacity of work. It contains arecoline which is highly toxic and has several untoward side effects on endocrine functions. In this article, the role of arecoline on thyroid function under metabolic stress was investigated in mice. Read More

    Oxidative stress, endocrine disruption, and malformation of Bufo gargarizans embryo exposed to sub-lethal cadmium concentrations.
    Environ Toxicol Pharmacol 2017 Jan 12;49:97-104. Epub 2016 Dec 12.
    College of Life Science, Shaanxi Normal University, Xi'an 710119, China. Electronic address:
    Thyroid hormone (TH) is critical for vertebrate postembryonic development as well as embryonic development. Chinese toad (Bufo gargarizans) embryos were exposed to different concentrations of cadmium (5, 50, 100, 200 and 500μg Cd L(-1)) for 7days. Malformations were monitored daily, and growth and development of embryos were measured at day 4 and 7, and type 2 and 3 iodothyronine deiodinase (Dio2 and Dio3), thyroid hormone receptors (TRα and TRβ) mRNA levels were also measured to assess disruption of TH synthesis. Read More

    Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS).
    Toxicol In Vitro 2017 Apr 12;40:66-78. Epub 2016 Dec 12.
    Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address:
    The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals that may disrupt the thyroid signaling pathway. Read More

    Approaches for grouping of pesticides into cumulative assessment groups for risk assessment of pesticide residues in food.
    Regul Toxicol Pharmacol 2017 Feb 10;83:89-99. Epub 2016 Dec 10.
    Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany. Electronic address:
    The European Food Safety Authority (EFSA) is developing approaches to cumulative risk assessment of pesticides by assigning individual pesticides to cumulative assessment groups (CAGs). For assignment to CAGs, EFSA recommended to rely on adverse effects on the specific target system. Contractors to EFSA have proposed to allocate individual pesticides into CAGs relying on NOAELs for effects on target organs. Read More

    Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1).
    Br J Clin Pharmacol 2017 Jun 19;83(6):1176-1184. Epub 2017 Jan 19.
    Department of Pediatrics, Division of Hematology and Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    OATP1B1 (SLCO1B1) is predominantly expressed at the basolateral membrane of hepatocytes and is critically important for the hepatic uptake and clearance of numerous drug substrates and endogenous compounds. In general, the organic anion transporting polypeptides (OATP; SLCO) represent a superfamily of uptake transporters that mediate the sodium-independent transport of a diverse range of amphipathic organic compounds including bile salts, steroid conjugates, thyroid hormones, anionic peptides, numerous drugs and other xenobiotic substances. OATP1B1 is highly polymorphic and a number of relevant and ethnically dependent polymorphisms have been identified and functionally characterized. Read More

    Toxicologic effects of 28-day dietary exposure to the flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)-cyclohexane (TBECH) in F344 rats.
    Toxicology 2017 Feb 5;377:1-13. Epub 2016 Dec 5.
    Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON, K1A 0K9, Canada.
    The brominated flame retardant TBECH is used as an additive to delay ignition and inhibit fires in construction materials and consumer goods. Trends in human exposure are not clear, although humans may be exposed to TBECH via indoor dust and air. In birds and fish there is some evidence of disruption in endocrine and reproductive parameters due to TBECH. Read More

    Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats.
    Toxicology 2017 Feb 1;377:25-37. Epub 2016 Dec 1.
    Universidade Federal de São Paulo, Unifesp/EPM, Departamento de Medicina, Disciplina de Endocrinologia Clínica, Laboratório de Endocrinologia Molecular e Translacional (LEMT), São Paulo, Brazil. Electronic address:
    Glyphosate-based herbicides (GBHs) are widely used in agriculture. Recently, several animal and epidemiological studies have been conducted to understand the effects of these chemicals as an endocrine disruptor for the gonadal system. The aim of the present study was to determine whether GBHs could also disrupt the hypothalamic-pituitary-thyroid (HPT) axis. Read More

    Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013.
    Environ Res 2017 Feb 29;153:63-72. Epub 2016 Nov 29.
    National Environmental Health Research Center, National Institute of Environmental Health Science, National Health Research Institutes, Miaoli, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Safety, Health and Environmental Engineering, National United University, Taiwan.
    Background: Previous epidemiologic and toxicological studies provide some inconsistent evidence that exposure to phthalates may affect thyroid function and growth hormone homeostasis.

    Objective: To assess the relations between exposure to phthalates and indicators of thyroid function and growth hormone homeostasis disturbances both among adults and minors.

    Methods: We conducted a population-based cross-sectional study of 279 Taiwanese adults (≥18 years old) and 79 minors (<18 years old) in 2013. Read More

    Morphofunctional Changes in the Thyroid Gland of Pubertal and Postpubertal Rats Exposed to Low Dose of DDT.
    Bull Exp Biol Med 2016 Dec 1;162(2):260-263. Epub 2016 Dec 1.
    Research Institute of Human Morphology, Moscow, Russia.
    Consumption of low dose DDT from birth until puberty suppressed functional activity of the thyroid gland in rats and leads to destructive changes in the organ during the postpubertal period with compensatory stimulation of secretory activity of thyrocytes aimed at normalization of thyroxin production. Read More

    Thyroid Function after Postoperative Radiation Therapy in Patients with Breast Cancer
    Asian Pac J Cancer Prev 2016 10 1;17(10):4577-4581. Epub 2016 Oct 1.
    Department of Radiotherapy, Regional Clinical Hospital in Zielona Gora Zyty 26, 65-001 Zielona Gora, Poland |University of Zielona Gora, Faculty of Medicine and Health Sciences, Poland, Email:
    Objective: The aim of this study was to assess thyroid function in breast cancer patients exposed to therapeutic external beam radiation. The focus was on possible progressive changes and any relationships between the incidence of primary hypothyroidism, the time required to become hypothyroid, and factors such as chemotherapy, hormonotherapy and immunotherapy. Materials and Methods: Seventy females undergoing 3D conformal and IMRT radiation therapy for breast cancers were enrolled in a non-randomized prospective study. Read More

    Tetraiodothyroacetic acid-conjugated polyethylenimine for integrin receptor mediated delivery of the plasmid encoding IL-12 gene.
    Colloids Surf B Biointerfaces 2017 Feb 5;150:426-436. Epub 2016 Nov 5.
    Department of Pharmaceutical Biotechnology and Pharmaceutical Sciences Research Center, Shiraz School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Center for Nanotechnology in Drug Delivery, Shiraz School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
    Targeted delivery by polymer-based nanoparticles has been considered as an efficient approach to transfer genetic materials into cells. Considering the over expression of integrin αVβ3 receptor on tumor cells and the presence of the binding site for tetraiodothyroacetic acid (tetrac) on integrin receptor, we hypothesized that the conjugation of tetrac to polyethylenimine (PEI) might be an effective strategy for pDNA delivery into the cells over-expressing integrins on their surfaces. In order to test the hypothesis, tetrac conjugated PEI/plasmid DNA complexes were prepared and their ability in the delivery of plasmid encoding IL-12 gene was investigated. Read More

    Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles.
    Environ Toxicol Pharmacol 2016 Dec 3;48:237-244. Epub 2016 Nov 3.
    Department of Biology, Texas Christian University, Fort Worth, TX, 76129, USA. Electronic address:
    Few studies have investigated the thyroid-disrupting effects of polybrominated diphenyl ethers (PBDEs) across multiple levels of biological organization in anurans, despite their suitability for the screening of thyroid disruptors. Therefore, the present study evaluated the effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on development, thyroid histology and thyroid hormone-related gene expression in Xenopus laevis exposed to 0 (control), 50 (low), 500 (medium) or 5000μg BDE-47/g food (high) for 21days. Only the high dose of BDE-47 hindered growth and development; however, thyroid hormone-associated gene expression was downregulated in the brains of tadpoles regardless of dose. Read More

    Gallic acid attenuates chromium-induced thyroid dysfunction by modulating antioxidant status and inflammatory cytokines.
    Environ Toxicol Pharmacol 2016 Dec 27;48:225-236. Epub 2016 Oct 27.
    Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt.
    Hexavalent chromium-mediated oxidative stress causes severe organ damage. The present study was designed to investigate the possible thyroprotective effect and underlying mechanisms of gallic acid using rat model of potassium dichromate-induced thyroid dysfunction. Forty adult male albino rats were divided into 4 groups: control, gallic acid (20mg GA/kg b. Read More

    Effects of exposure to microcystin-LR at environmentally relevant concentrations on the metabolism of thyroid hormones in adult zebrafish (Danio rerio).
    Toxicon 2016 Dec 4;124:15-25. Epub 2016 Nov 4.
    College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, PR China; Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan, 430070, PR China; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan, 430070, PR China.
    Microcystin-LR (MC-LR) has the potential to disturb thyroid hormone homeostasis. However, the effects of MC-LR at environmentally relevant concentrations on the thyroid system in adult fish are still unclear. In this study, adult zebrafish were exposed to 0, 1, 5, and 25 μg/L MC-LR for 7, 14, 21, and 28 days. Read More

    Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback.
    Gen Comp Endocrinol 2017 Mar 1;243:60-69. Epub 2016 Nov 1.
    Center for Bioengineering Innovation & Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA. Electronic address:
    Perchlorate is a ubiquitous environmental contaminant that has widespread endocrine disrupting effects in vertebrates, including threespine stickleback (Gasterosteus aculeatus). The target of perchlorate is thyroid tissue where it induces changes in the organization, activation, and morphology of thyroid follicles and surrounding tissues. To test the hypothesis that some phenotypes of perchlorate toxicity are not mediated by thyroid hormone, we chronically exposed stickleback beginning at fertilization to perchlorate (10, 30, 100ppm) or control water with and without supplementation of either iodide or thyroxine (T4). Read More

    Triclosan exposure results in alterations of thyroid hormone status and retarded early development and metamorphosis in Cyprinodon variegatus.
    Aquat Toxicol 2016 Dec 24;181:1-10. Epub 2016 Oct 24.
    Laboratory of Oceanology, MARE, B6c, Liège University, Liège, Belgium. Electronic address:
    Thyroid hormones are critically involved in somatic growth, development and metamorphosis of vertebrates. The structural similarity between thyroid hormones and triclosan, an antimicrobial compound widely employed in consumer personal care products, suggests triclosan can have adverse effects on the thyroid system. The sheepshead minnow, Cyprinodon variegatus, is now used in ecotoxicological studies that have recently begun to focus on potential disruption of the thyroid axis by endocrine disrupting compounds. Read More

    Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists.
    J Med Chem 2016 Nov 9;59(22):10209-10227. Epub 2016 Nov 9.
    New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061, Korea.
    We evaluated the in vitro pharmacology as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chemical entities that not only were shown to be highly selective agonists for ERRγ but also exhibited enhanced pharmacokinetic profile compared with 3 (GSK5182). 6g and 10b had comparable potency to 3 and were far more selective for ERRγ over the ERRα, -β, and ERα. The in vivo pharmacokinetic profiles of 6g and 10b were further evaluated, as they possessed superior in vitro ADMET profiles compared to the other compounds. Read More

    An assessment of exposure and effects of persistent organic pollutants in an urban Cooper's hawk (Accipiter cooperii) population.
    Ecotoxicology 2017 Jan 28;26(1):32-45. Epub 2016 Oct 28.
    Department of Biological Sciences, Simon Fraser University, Burnaby, BC, V5A 1 S7, Canada.
    Among the stressors confronting urban wildlife, chemical contaminants pose a particular problem for high trophic feeding species. Previous data from fortuitous carcass collections revealed surprisingly high levels of persistent organic pollutants in raptor species, including the Cooper's hawk (Accipiter cooperii), from urbanized areas of southwestern British Columbia, Canada. Thus, in 2012 and 2013, we followed up on that finding by measuring POPs in blood samples from 21 adult and 15 nestling Cooper's hawks in Vancouver, a large urban area in southwestern Canada. Read More

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