3,421 results match your criteria Toxicity Thyroid Hormone


Human riboflavin kinase: Species-specific traits in the biosynthesis of the FMN cofactor.

FASEB J 2020 Jul 10. Epub 2020 Jul 10.

Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain.

Human riboflavin kinase (HsRFK) catalyzes vitamin B (riboflavin) phosphorylation to flavin mononucleotide (FMN), obligatory step in flavin cofactor synthesis. HsRFK expression is related to protection from oxidative stress, amyloid-β toxicity, and some malignant cancers progression. Its downregulation alters expression profiles of clock-controlled metabolic-genes and destroys flavins protection on stroke treatments, while its activity reduction links to protein-energy malnutrition and thyroid hormones decrease. Read More

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http://dx.doi.org/10.1096/fj.202000566RDOI Listing

Regulation of Thyroid Disrupting Chemicals to Protect the Developing Brain.

Endocrinology 2020 Jul 2. Epub 2020 Jul 2.

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, DK, Denmark.

Manmade chemicals with endocrine disrupting properties are pervasive in the environment and are present in the bodies of humans and in wildlife. As thyroid hormones (THs) control normal brain development, and maternal hypothyroxinemia is associated with neurological impairments in children, chemicals that interfere with TH signaling are of considerable concern for children's health. However, identifying thyroid disrupting chemicals (TDCs) in vivo is largely based on serum tetraiodothyronine (T4) measures in rats, which may be inadequate to assess TDCs with disparate mechanisms of action. Read More

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http://dx.doi.org/10.1210/endocr/bqaa106DOI Listing

Emerging environmental pollutants hydroxylated polybrominated diphenyl ethers: From analytical methods to toxicology research.

Mass Spectrom Rev 2020 Jul 1. Epub 2020 Jul 1.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China.

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are of particular concern due to their ubiquitous distribution and adverse health effects. Significant progress has been made in the characterization of OH-PBDEs by using mass spectrometry (MS). In this review, we summarize applications of MS-based techniques in detection, environmental and biota distribution, and potential health risk effects, hoping to unfold an overall picture on account of current knowledge of OH-PBDEs. Read More

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http://dx.doi.org/10.1002/mas.21640DOI Listing

Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes.

Toxicol Rep 2020 11;7:730-742. Epub 2020 Jun 11.

Department of Pharmacognosy, SVKM's NMIMS, School of Pharmacy & Technology Management Mukesh Patel Technology Park, Babulde, Mumbai-Agra Highway, Shirpur, India.

Hypothyroidism is the most frequent consequence of the interaction of a large variety of drugs, environmental pollutants and industrial chemicals with the thyroid gland. It is associated with diminished endocrine function which may lead to hyperlipidemia, diabetes, Alzheimer's disease, weight gain, and other metabolic disorders. The present study evaluates the pro-thyroid activity of a bioactive fraction from a polyherbal teabag in rats with hypothyroidism induced by propylthiouracil. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301176PMC

Stereoselective environmental behavior and biological effects of the chiral bitertanol.

Sci Total Environ 2020 Aug 22;728:138867. Epub 2020 Apr 22.

Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing 210095, China. Electronic address:

Bitertanol is a widely used chiral triazole fungicide. The stereoselective environmental behavior and biological effects of bitertanol are not clear. The present study evaluated the stereoselectivity of bitertanol, including its degradation in five typical soils (under laboratory controlled aerobic, anaerobic and sterilization conditions), metabolism in rat liver microsomes (RLM; in vitro), and the endocrine disruption effects on the estrogen receptor (ER) and thyroid hormone receptor (TR) using reporter gene assays. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138867DOI Listing
August 2020
4.099 Impact Factor

Trifluoroiodomethane (CF3I) (2019).

Authors:

Toxicol Ind Health 2020 May 16;36(5):310-321. Epub 2020 Jun 16.

Trifluoroiodomethane (CFI) is a colorless and odorless gas used primarily as a fire suppressant. CFI has low acute inhalation toxicity. The no-observed adverse effect level (NOAEL) of CFI for cardiac sensitization in dogs was 2000 ppm. Read More

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http://dx.doi.org/10.1177/0748233720930549DOI Listing

Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR's toxicological profile database.

Int J Environ Health Res 2020 Jun 4:1-18. Epub 2020 Jun 4.

US Department of Health and Human Services, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR) , Atlanta, GA, USA.

This review utilizes the robust database of literature contained in toxicological profiles developed by the Agency for Toxic Substances and Disease Registry. The aim was to use this database to identify developmental toxicity studies reporting alterations in hormone levels in the developing fetus and offspring and identify windows of sensitivity. We identified 74 oral exposure studies in rats that provided relevant information on 30 chemicals from 21 profiles. Read More

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http://dx.doi.org/10.1080/09603123.2020.1772204DOI Listing

An overview on performance and image enhancing drugs (PIEDs) confiscated in Italy in the period 2017-2019.

Clin Toxicol (Phila) 2020 Jun 1:1-6. Epub 2020 Jun 1.

Department of Health Surveillance and Bioethics, Forensic Toxicology Laboratory, Università Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, Rome, Italy.

The illegal market of counterfeit and falsified medicines and supplements containing unlabeled pharmaceuticals is expanding worldwide. They are usually referred to by the term "performance and image enhancing drugs" (PIEDs) and are mainly steroids, stimulants, hormones, and drugs for erectile dysfunction. PIEDs are easily accessible through the online or black markets. Read More

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http://dx.doi.org/10.1080/15563650.2020.1770277DOI Listing

Changes in thyroid hormone levels and related gene expressions in embryo-larval zebrafish exposed to binary combinations of bifenthrin and acetochlor.

Ecotoxicology 2020 Jul 28;29(5):584-593. Epub 2020 May 28.

Key Laboratory of Agrifood Safety and Quality, Ministry of Agriculture of China, 100081, Beijing, PR China.

Bifenthrin (BF) and acetochlor (AT) are widely used as an insecticide and herbicide, respectively, which are introduced to the aquatic environment as a natural result. Although the thyroid active substances may coexist in the environment, their joint effects on fish have not been identified. We examined the joint toxicity of BF and AT in zebrafish (Danio rerio) in this study. Read More

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http://dx.doi.org/10.1007/s10646-020-02206-3DOI Listing

Ethanol Extract of Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway.

Front Pharmacol 2020 29;11:606. Epub 2020 Apr 29.

Department of Thyroid and Breast Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Triple-negative breast cancer (TNBC) is an aggressive disease with worst prognosis than other subtypes of breast cancer. Owing to the lack of hormone receptors and HER2 expression on TNBC cells, patients do not have targeted therapy options available with other breast cancer subtypes. Extensive efforts have been made to identify novel therapeutics against TNBC. Read More

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http://dx.doi.org/10.3389/fphar.2020.00606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201043PMC

Adjuvant immunotherapy: the sting in the tail.

Eur J Cancer 2020 Jun 5;132:207-210. Epub 2020 May 5.

Institute of Cancer Sciences, University of Manchester and the Christie NHS Foundation Trust, Manchester, UK. Electronic address:

Adjuvant therapy with PD-1 inhibitors for resected Stage III/IV melanoma reduces the risk of recurrence by 40-50% and is now a standard of care. Immune-related adverse events occurred in approximately 37% of patients in the pivotal trials, 10-15% were severe (grade III-IV). Endocrine toxicities were common and mostly irreversible. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.03.016DOI Listing

Subchronic Toxicity of the New Iodine Complex in Dogs and Rats.

Front Vet Sci 2020 17;7:184. Epub 2020 Apr 17.

Scientific Center for Anti-infectious Drugs, Almaty, Kazakhstan.

Complexes of iodine (povidone-iodine and cadexomers) are among the most important antiseptics used in clinical and veterinary medicines. However, high local irritation activity and systemic toxicity limits their oral administration. The purpose of the study was to compare the effect of a new complex of iodine (PA, potentiator of anticancer antibiotics), in which iodine is coordinated by carbohydrates and polypeptides) on the organisms of rats and dogs treated orally with the drug for 30 days. Read More

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http://dx.doi.org/10.3389/fvets.2020.00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181231PMC

Microplastics enhance the developmental toxicity of synthetic phenolic antioxidants by disturbing the thyroid function and metabolism in developing zebrafish.

Environ Int 2020 Jul 29;140:105750. Epub 2020 Apr 29.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China. Electronic address:

Coexposure of MPs and other contaminants adsorbed from the environment has raised many attentions, but the understanding of the combined effects of MPs and plastic additives are limited. Butylated hydroxyanisole (BHA), a widely used synthetic phenolic antioxidant in plastics, has gained high concerns due to their unintended environmental release and potential threat to aquatic organisms. This study was conducted to reveal the influences of MPs on the bioaccumulation and developmental toxicity of BHA in zebrafish larvae. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105750DOI Listing

Molecular interactions of thyroxine binding globulin and thyroid hormone receptor with estrogenic compounds 4-nonylphenol, 4-tert-octylphenol and bisphenol A metabolite (MBP).

Authors:
Ishfaq A Sheikh

Life Sci 2020 Jul 30;253:117738. Epub 2020 Apr 30.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

Aim: Endocrine disruption due to environmental chemical contaminants is a global human health issue. The aim of present study was to investigate the structural binding aspects of possible interference of commonly detected environmental contaminants on thyroid function.

Material And Methods: Three compounds, 4-tert-octylphenol (4-tert-OP), 4-nonylphenol (4-NP), and 4-methyl-2,4-bis(4-hydroxypentyl)pent-1-ene (MBP) were subjected to induced fit docking (IFD) against thyroxine binding globulin (TBG) and thyroid hormone receptor (THR). Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117738DOI Listing

Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project.

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

School of Science and Technology, Orebro University, SE-701 82 Orebro, Sweden.

The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Read More

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http://dx.doi.org/10.3390/ijms21093123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247692PMC
April 2020
2.862 Impact Factor

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration.

Cell Prolif 2020 May 29;53(5):e12808. Epub 2020 Apr 29.

Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.

Objectives: Although the hepatomitogenic activity of triiodothyronine (T3) is well established, the wide range of harmful effects exerted by this hormone precludes its use in liver regenerative therapy. Selective agonists of the beta isoform of thyroid hormone receptor (TRβ) do not exhibit T3-induced cardiotoxicity and show a good safety profile in patients with NASH. The aim of this study was to investigate whether two novel TRβ agonists, the prodrug TG68 and the active compound IS25 could stimulate hepatocyte proliferation without T3/TRα-dependent side effects. Read More

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http://dx.doi.org/10.1111/cpr.12808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260063PMC

Hormonal and molecular alterations induced by sub-lethal toxicity of zinc oxide nanoparticles on .

Saudi J Biol Sci 2020 May 16;27(5):1296-1301. Epub 2020 Jan 16.

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.

This study was carried out to determine the biochemical and molecular potential effects of Zn-ONPs sub-lethal toxicity on the hormonal profile of (O. niloticus). One hundred and fifty juvenile female were used in this experiment; Ninety for determination of LC50 and other 60 fish were divided into 3 groups with 20 fish each (two replicate in each group). Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182787PMC

Thyroid disruption and developmental toxicity caused by Cd in Schizopygopsis younghusbandi larvae.

Comp Biochem Physiol C Toxicol Pharmacol 2020 Sep 25;235:108783. Epub 2020 Apr 25.

Fishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of the Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address:

In recent years, the adverse effects of cadmium (Cd) on aquatic systems have attracted much attention because Cd can induce endocrine disorders and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in native fish in Lhasa are still unclear. In the present study, Schizopygopsis younghusbandi larvae were exposed to Cd (0. Read More

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http://dx.doi.org/10.1016/j.cbpc.2020.108783DOI Listing
September 2020

Parental exposure to cadmium chloride causes developmental toxicity and thyroid endocrine disruption in zebrafish offspring.

Comp Biochem Physiol C Toxicol Pharmacol 2020 Aug 25;234:108782. Epub 2020 Apr 25.

Shaanxi Institute of Pediatric Diseases, Xi'an Key Laboratory of Children's Health and Diseases, Xi'an Children's Hospital, Xi'an, Shaanxi 710003, PR China. Electronic address:

Cadmium is a common heavy metal pollutant. Previous studies have found that long-term cadmium exposure can cause damage to multiple organs/systems in humans and experimental animals; however, there are few studies that elucidate its effects on offspring development, discuss whether it can be transmitted to offspring from the parent, and debate whether it affects the functional development of the thyroid hormone system in offsprings. In this study, sexually mature zebrafish were exposed to different concentrations of cadmium chloride (0. Read More

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http://dx.doi.org/10.1016/j.cbpc.2020.108782DOI Listing

Toxicokinetics and persistent thyroid hormone disrupting effects of chronic developmental exposure to chlorinated polyfluorinated ether sulfonate in Chinese rare minnow.

Environ Pollut 2020 Aug 1;263(Pt B):114491. Epub 2020 Apr 1.

Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.

The abnormality in thyroid hormone modulation in developmental fish, vulnerable to per- and polyfluorinated substances, is of particular concerns for the alternative substances. Juvenile rare minnows, were exposed to chlorinated polyfluoroalkyl ether sulfonates (Cl-PFESAs), the novel alternatives to perfluorooctane sulfonate (PFOS), for 4 weeks followed by 12 weeks of depuration. Half lives were determined to be 33 d, 29 d, and 47 d for total Cl-PFESAs, C8 Cl-PFESA and C10 Cl-PFESA, respectively. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114491DOI Listing
August 2020
4.143 Impact Factor

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence.

Int J Environ Res Public Health 2020 Apr 13;17(8). Epub 2020 Apr 13.

Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.

Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen and androgen activities, as well as being suspected of other health outcomes. Given the crucial role of thyroid hormones and the increasing incidence of thyroid carcinoma in the last few decades, this review analyzes the effects of BPS on the thyroid, considering original research in vitro, in vivo, and in humans published from January 2000 to October 2019. Both in vitro and in vivo studies reported the ability of BPs to disrupt thyroid function through multiple mechanisms. Read More

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http://dx.doi.org/10.3390/ijerph17082654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216215PMC

Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70 a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity.

Auto Immun Highlights 2019 Dec 7;10(1):11. Epub 2019 Nov 7.

AV7 Limited, FIRS Laboratories, Parc Ty Glas, Llanishen, Cardiff, CF14 5DU UK.

Background: The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies.

Methods: The preclinical toxicology assessment following weekly intravenous (IV) or intramuscular (IM) administration of K1-70™ in rats and cynomolgus monkeys for 29 days was carried out. An assessment of delayed onset toxicity and/or reversibility of toxicity was made during a further 4 week treatment free period. Read More

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http://dx.doi.org/10.1186/s13317-019-0121-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065368PMC
December 2019

Toxicity of canola-derived glucosinolates in pigs fed resistant starch-based diets.

J Anim Sci 2020 May;98(5)

Department of Animal Science, South Dakota State University, Brookings, SD.

A study was conducted to determine effects of reducing hindgut pH through dietary inclusion of high-amylose cornstarch (HA-starch) on growth performance, organ weights relative to live body weight (BW), blood thyroid hormone levels, and glucosinolate degradation products of nursery pigs fed cold-pressed canola cake (CPCC). A total of 240 pigs (initial BW: 7.1 kg), which had been weaned at 21 d of age, were housed in 40 pens (6 pigs per pen) and fed 4 diets (10 pens per diet) in a randomized complete block design for 28 d. Read More

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http://dx.doi.org/10.1093/jas/skaa111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320599PMC

Thyroid-disrupting effects and mechanism of thiazole-Zn-induced thyroid cell hypertrophy and hyperplasia in male Sprague-Dawley rats.

Ecotoxicol Environ Saf 2020 Jun 3;196:110544. Epub 2020 Apr 3.

Tianjin Institute of Environmental and Operational Medicine, Tianjin, 30050, China. Electronic address:

Thiazole-Zn is a systemic fungicide synthesized and developed in China that has been used for the prevention and treatment of bacterial and fungal diseases on fruits and vegetables. Thiazole-Zn is a new thyroid disruptor chemical. The purpose of this study was to clarify the thyroid-disrupting property of thiazole-Zn and the mechanism responsible for thyroid hormone (TH) biosynthesis inhibition in male rats induced by thiazole-Zn. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110544DOI Listing
June 2020
2.762 Impact Factor

Thyroid Dysfunction Related to the Antiangiogenic VEGFR2-Binding Monoclonal Antibody Ramucirumab: A Series of 14 Cases and a Descriptive Study.

Biol Pharm Bull 2020 ;43(4):752-756

Department of Pharmacy, Shiga University of Medical Science Hospital.

Hypothyroidism is a well-established toxicity of small-molecule anti-vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors. However, its association with anti-VEGF biologics is uncertain. The aim of this study was to investigate the incidence, time course, clinical features, and severity of thyroid dysfunction in patients receiving ramucirumab (an antiangiogenic VEGF receptor 2-binding monoclonal antibody). Read More

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http://dx.doi.org/10.1248/bpb.b19-01071DOI Listing
January 2020

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.

PLoS Biol 2020 03 27;18(3):e3000688. Epub 2020 Mar 27.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.

Obesity leads to multiple health problems, including diabetes, fatty liver, and even cancer. Here, we report that urolithin A (UA), a gut-microflora-derived metabolite of pomegranate ellagitannins (ETs), prevents diet-induced obesity and metabolic dysfunctions in mice without causing adverse effects. UA treatment increases energy expenditure (EE) by enhancing thermogenesis in brown adipose tissue (BAT) and inducing browning of white adipose tissue (WAT). Read More

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http://dx.doi.org/10.1371/journal.pbio.3000688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141696PMC

Titanium dioxide nanoparticles enhanced thyroid endocrine disruption of pentachlorophenol rather than neurobehavioral defects in zebrafish larvae.

Chemosphere 2020 Jun 17;249:126536. Epub 2020 Mar 17.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academic of Science, Wuhan, 430072, China.

This study investigated the influences of titanium dioxide nanoparticles (n-TiO) on the thyroid endocrine disruption and neurobehavioral defects induced by pentachlorophenol (PCP) in zebrafish (Danio rerio). Embryos (2 h post-fertilization) were exposed to PCP (0, 3, 10, and 30 μg/L) or in combination with n-TiO (0.1 mg/L) until 6 days post-fertilization. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126536DOI Listing

[Effect of niclosamide on thyroid endocrine system of larval zebrafish].

Authors:
B R Zhu B Li

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Sep;32(1):78-82

Hubei Center for Disease Control and Prevention, China.

Objective: To examine the effect of niclosamide on thyroid endocrine disruption in larval zebrafish.

Methods: Zebrafish embryos (2 hours post-fertilization) were exposed to niclosamide at concentrations of 0, 5, 10, 20, 40 μg/L and 80 μg/L until 120 hours post-fertilization, and the body weight, hatching rate, malformation rate and survival rate of zebrafish embryos/larvae were measured. In addition, the triiodothyronine (T3) and thyroxin (T4) activities were determined in zebrafish, and the expression of and genes that were associated with the regulation of thyroid hormones was quantified using a quantitative real-time PCR (qPCR) assay. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019085DOI Listing
September 2019

Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae.

Toxicol Appl Pharmacol 2020 May 12;394:114957. Epub 2020 Mar 12.

Fishery Resources and Environmental Science Experimental Station of The Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address:

The adverse effects of triphenyltin (TPT) on aquatic systems have attracted much attention because TPT is widely used and prevalent in aquatic environments. Here, zebrafish embryos/larvae were exposed to TPT (0, 0.039, 0. Read More

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http://dx.doi.org/10.1016/j.taap.2020.114957DOI Listing
May 2020
3.705 Impact Factor

Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos.

Aquat Toxicol 2020 May 9;222:105466. Epub 2020 Mar 9.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. Electronic address:

The co-occurrence of hypoxia and xenobiotics is extremely common in natural environments, highlighting the necessity to elicit their interaction on aquatic toxicities. In the present study, marine medaka embryos were exposed to various concentrations (nominal 0, 1, 3.3 and 10 mg/L) of perfluorobutane sulfonate (PFBS), an environmental pollutant of emerging concern, under either normoxia (6. Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105466DOI Listing

Renal protective effects of grape seed extract treatment against Eltroxin-induced hyperthyroidism, kidney damage, and oxidative stress in male mice.

Environ Sci Pollut Res Int 2020 May 12;27(15):17963-17971. Epub 2020 Mar 12.

Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

The present study aimed to investigate the influence of grape seed extract (GSE) in renal toxicity, oxidative stress, and Bcl-2 expressions in Eltroxin-induced hyperthyroidism to male mice. GSE was evaluated through oral administration to male mice at dose 50 mg/kg daily for 3 consecutive weeks. Eltroxin (100 μg/kg) was administered to mice for 3 weeks, and the mice were posttreated with GSE for another 3 weeks. Read More

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http://dx.doi.org/10.1007/s11356-020-08210-8DOI Listing

Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction.

Endocr Connect 2020 Mar 1. Epub 2020 Mar 1.

M Pirmohamed, Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom of Great Britain and Northern Ireland.

Intoduction: Immune checkpoint inhibitors can lead to thyroid dysfunction. However the understanding of the clinical phenotype of ICI-induced thyroid dysfunction in the real-world population is limited. The purpose of this study was to characterise the clinical patterns of dysfunction and evaluate the demographic, biochemical and immunological features associated with this patient cohort. Read More

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http://dx.doi.org/10.1530/EC-19-0473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159260PMC

Organochlorine pesticides: Agrochemicals with potent endocrine-disrupting properties in fish.

Mol Cell Endocrinol 2020 May 26;507:110764. Epub 2020 Feb 26.

Department of Physiological Sciences, Center for Environmental and Human Toxicology, UF, USA; Genetics Institute, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611, USA. Electronic address:

Organochlorine pesticides (OCPs) are persistent environmental contaminants that act as endocrine disruptors and organ system toxicants. These pesticides (e.g. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110764DOI Listing

An Adolescent Female with Bipolar Disorder Presenting with Lithium-Induced Hyperthyroidism.

Case Rep Endocrinol 2020 12;2020:1283464. Epub 2020 Feb 12.

Department of Pediatric Endocrinology, Children's Mercy Hospital, 3101 Broadway Blvd., Kansas City, MO 64111, USA.

Lithium therapy has been associated with several endocrine disorders including thyroid dysfunction, diabetes insipidus, and hyperparathyroidism. While its suppressive effect on thyroid function is well known, it is very rare to observe lithium-induced hyperthyroidism especially in the pediatric population. Here, we describe a case of lithium-induced hyperthyroidism in an adolescent female with bipolar disorder. Read More

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http://dx.doi.org/10.1155/2020/1283464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037979PMC
February 2020

Perinatal low-dose PBDE-47 exposure hampered thyroglobulin turnover and induced thyroid cell apoptosis by triggering ER stress and lysosomal destabilization contributing to thyroid toxicity in adult female rats.

J Hazard Mater 2020 06 10;392:122265. Epub 2020 Feb 10.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of Education, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address:

Evidence demonstrates that 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) is able to disturb thyroid hormones (THs) homeostasis, yet the mechanisms remain unknown. We sought to investigate the effects of PBDE-47 on endoplasmic reticulum (ER) and lysosomes in thyroids. Using female Sprague-Dawley rats orally administered PBDE-47 at environmentally relevant doses (0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122265DOI Listing
June 2020
4.529 Impact Factor

Renal Toxicity of Cancer Immunother apy.

Authors:
T Büchler

Klin Onkol 2020 ;33(1):29-31

Background: Acute renal impairment is a relatively rare complication of anti-tumour immunotherapy. The incidence of renal toxicity due to immuno-oncological therapy is relatively low, approximately 2% in patients treated with PD-1/PD-L1 inhibitors and 4.5% with combination treatments with PD-1/PD-L1 therapy and a CTLA-4 inhibitor. Read More

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http://dx.doi.org/10.14735/amko202029DOI Listing
January 2020

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.

Klin Onkol 2020 ;33(1):15-19

Modern immunotherapy with checkpoint inhibitors has become the backbone treatment for many cancers. However, it is often accompanied by immune-related side effects, which may differ depending on the nature of the treatment. The frequency of adverse reactions increases with the number of patients receiving immunotherapy. Read More

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http://dx.doi.org/10.14735/amko202015DOI Listing
January 2020

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX).

Environ Health Perspect 2020 Feb 13;128(2):27006. Epub 2020 Feb 13.

Division of the National Toxicology Program (DNTP), NTP Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, North Carolina, USA.

Background: Perfluorooctanoic acid (PFOA) is a poly- and perfluoroalkyl substance (PFAS) associated with adverse pregnancy outcomes in mice and humans, but little is known regarding one of its replacements, hexafluoropropylene oxide dimer acid (HFPO-DA, referred to here as GenX), both of which have been reported as contaminants in drinking water.

Objectives: We compared the toxicity of PFOA and GenX in pregnant mice and their developing embryo-placenta units, with a specific focus on the placenta as a hypothesized target.

Methods: Pregnant CD-1 mice were exposed daily to PFOA (0, 1, or ) or GenX (0, 2, or ) via oral gavage from embryonic day (E) 1. Read More

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http://dx.doi.org/10.1289/EHP6233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064328PMC
February 2020

Competitive binding assays for measuring the binding affinity of thyroid-disrupting chemicals for integrin αβ.

Chemosphere 2020 Jun 1;249:126034. Epub 2020 Feb 1.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. Electronic address:

Some thyroid-disrupting chemicals (TDCs) affect thyroid function by activating the pathways mediated by a typical thyroid hormone (TH) membrane receptor, integrin αβ. The present study introduces improved competitive binding assays for the rapid and sensitive evaluation of the binding affinities of TDCs for integrin αβ Based on different probes, two assays were modified: a fluorescence competitive binding assay and a radioligand competitive binding assay. The chemicals tested included the known TH, 3,3',5,5'-tetraiodo-l-thyronine (T4); a deaminated analog of T4, tetraiodothyroacetic acid (tetrac); and phthalate esters (PAEs). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126034DOI Listing

Metabolomics evaluation of repeated administration of potassium iodide on adult male rats.

Arch Toxicol 2020 03 11;94(3):803-812. Epub 2020 Feb 11.

Aix Marseille Univ, INSERM, INRAE, C2VN, BioMeT, Marseille, France.

The long-lasting consequence of a new iodine thyroid blocking strategy (ITB) to be used in case of nuclear accident is evaluated in male Wistar rats using a metabolomics approach applied 30 days after ITB completion. The design used 1 mg/kg/day of KI over 8 days. Thyroid hormones remained unchanged, but there was a metabolic shift measured mainly in thyroid then in plasma and urine. Read More

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http://dx.doi.org/10.1007/s00204-020-02666-wDOI Listing

Saussurea lappa root extract ameliorates the hazards effect of thorium induced oxidative stress and neuroendocrine alterations in adult male rats.

Environ Sci Pollut Res Int 2020 Apr 3;27(12):13237-13246. Epub 2020 Feb 3.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

The present study was aimed to estimating the effect of Saussurea lappa (costus) root extract on thorium accumulation in different brain regions (cerebral cortex, cerebellum, and hypothalamus) of adult male albino rats and also to evaluate the antioxidant effect and thyroid gland modulation activity of costus following thorium toxicity. Adult male rats were randomly allocated into four groups; control group receiving saline (0.9% NaCl), thorium group receiving an intraperitoneal (i. Read More

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http://dx.doi.org/10.1007/s11356-020-07917-yDOI Listing
April 2020
2.828 Impact Factor

[HEPATOCELLULAR TOXICITY IN THE BACKGROUND OF AMIODARON-INDUCED THYROID DYSFUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION].

Georgian Med News 2019 Dec(297):84-87

Ivano-Frankivsk National Medical University, Ukraine.

The purpose of the work was to establish the frequency and conditions in which structural and functional changes of the liver might occur in case of long-term amiodarone use, depending on thyroid dysfunction. The study included 80 patients with cardiosclerosis with atrial fibrillation (AF). The patients were assigned to: group I (n=60) - received amiodarone at a maintenance dose for one year (on background of basic therapy); control group (CG) - patients (n=20) who received on the background of basic therapy digoxin and bisoprolol. Read More

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December 2019

Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats.

Int J Environ Res Public Health 2020 01 23;17(3). Epub 2020 Jan 23.

Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia.

Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 -ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b. Read More

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http://dx.doi.org/10.3390/ijerph17030746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037109PMC
January 2020

PANCYTOPENIA AND LYMPHOID ORGAN HYPERPLASIA IN A PATIENT WITH GRAVES DISEASE: RESPONSE TO ANTITHYROID DRUG THERAPY.

AACE Clin Case Rep 2019 Nov-Dec;5(6):e388-e392. Epub 2019 Aug 28.

Objective: In rare instances, cytopenias manifest as a complication of thyrotoxicosis. Here, we report a case of Graves disease (GD) thyrotoxicosis presenting as pancytopenia that resolved with antithyroid therapy.

Methods: A 35-year-old male presented with fever and chills following an outpatient colonoscopy. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873849PMC

Gestational and lactational exposure to gossypol alters the testis transcriptome.

BMC Genomics 2020 Jan 17;21(1):59. Epub 2020 Jan 17.

Department of Animal Sciences, University of Florida, Gainesville, FL, 32611, USA.

Background: Reproductive capacity can be altered by challenges experienced during critical periods of development, including fetal development and early neonatal life. Gossypol is a polyphenolic compound, commonly found in cotton seeds, that impairs male reproduction. Here, we investigated whether the exposure to gossypol in utero and during lactation alters male reproductive function in sheep. Read More

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http://dx.doi.org/10.1186/s12864-020-6487-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969474PMC
January 2020

Embryo/larval toxicity and transcriptional effects in zebrafish (Danio rerio) exposed to endocrine active riverbed sediments.

Environ Sci Pollut Res Int 2020 Apr 16;27(10):10729-10747. Epub 2020 Jan 16.

ARPA - Regional Agency for Environmental Protection of Lombardy, Laboratories Sector, Via Rosellini, 17, 20124, Milan, Italy.

Sediment toxicity plays a fundamental role in the health of inland fish communities; however, the assessment of the hazard potential of contaminated sediments is not a common objective in environmental diagnostics or remediation. This study examined the potential of transcriptional endpoints investigated in zebrafish (Danio rerio) exposed to riverbed sediments in ecotoxicity testing. Embryo-larval 10-day tests were conducted on sediment samples collected from five sites (one upstream and four downstream of the city of Milan) along a polluted tributary of the Po River, the Lambro River. Read More

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http://dx.doi.org/10.1007/s11356-019-07417-8DOI Listing

Effects of perfluorooctanoic acid (PFOA) on the thyroid status, vitellogenin, and oxidant-antioxidant balance in the Murray River rainbowfish.

Ecotoxicology 2020 Mar 14;29(2):163-174. Epub 2020 Jan 14.

Ecotoxicology Research Group, School of Science, RMIT University, Bundoora West Campus, Melbourne, VIC, 3083, Australia.

Perfluorooctanoic acid's (PFOA) widespread use, presence and persistence in the aquatic environment has led to an increasing number of studies focusing on its toxicological effects. In Australia, PFOA has been detected in the aquatic environment, however its effects on Australian native fauna are unknown. In this study, male Australian native fish Murray River rainbowfish (Melanotaenia fluviatilis) were exposed to four different concentrations of PFOA (0. Read More

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http://dx.doi.org/10.1007/s10646-020-02161-zDOI Listing

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis.

Eur J Med Chem 2020 Feb 23;188:112006. Epub 2019 Dec 23.

Department of Pharmacy, University of Pisa, Pisa, 56126, Italy; Interdepartmental Research Centre for Biology and Pathology of Aging, University of Pisa, Pisa, Italy. Electronic address:

Although triiodothyronine (T3) induces several beneficial effects on lipid metabolism, its use is hampered by toxic side-effects, such as tachycardia, arrhythmia, heart failure, bone and muscle catabolism and mood disturbances. Since the α isoform of thyroid hormone receptors (TRs) is the main cause of T3-related harmful effects, several efforts have been made to develop selective agonists of the β isoform that could induce some beneficial effects (i.e. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.112006DOI Listing
February 2020

Evaluation of structurally different brominated flame retardants interacting with the transthyretin and their toxicity on HepG2 cells.

Chemosphere 2020 May 24;246:125749. Epub 2019 Dec 24.

Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan, Hubei, 430074, China. Electronic address:

Brominated flame retardants (BFRs) are found at quantifiable levels in both humans and wildlife and may potentially cause a health risk. For BFRs and their derivatives, limited information regarding the relationship among the structure, binding affinity to the target protein and toxicity is currently available. In the present work, representative BFRs with different hydroxyl- or bromo-substituents, namely 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), 3-hydroxy-2, 2', 4, 4'-tetrabromodiphenyl ether (3-OH-BDE-47) and tetrabromobisphenol A (TBBPA), were selected to investigate the interactions with transthyretin (TTR) by electrospray ionization mass spectrometry (ESI-MS) and cytotoxicity on HepG2 cells. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125749DOI Listing

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data.

Front Endocrinol (Lausanne) 2019 9;10:743. Epub 2019 Dec 9.

Muséum National d'Histoire Naturelle, CNRS UMR 7221, Laboratoire Physiologie moléculaire de l'adaptation, Paris, France.

Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield-reducing pests including insects, fungi, nematodes, and weeds. Concern has been raised that some pesticides may act as endocrine disrupting chemicals (EDCs) with the potential to interfere with the hormone systems of non-target invertebrates and vertebrates, including humans. EDCs act at low doses and particularly vulnerable periods of exposure include pre- and perinatal development. Read More

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http://dx.doi.org/10.3389/fendo.2019.00743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915086PMC
December 2019