3,883 results match your criteria Toxicity Thyroid Hormone


Effects of central nervous system drugs on androgen, estrogen α, glucocorticoid, and thyroid receptors.

Chem Biol Interact 2022 Jun 24:110030. Epub 2022 Jun 24.

University of Ljubljana, Faculty of Pharmacy, SI-1000, Ljubljana, Slovenia. Electronic address:

Some drugs that act on the central nervous system (CNS) are known to affect the endocrine system, although the mechanisms of endocrine toxicity are not well characterized to date. Such CNS drugs include antipsychotics, anticonvulsants, and antidepressants. In the present study, in-vitro firefly luciferase reporter-gene assays using the AR-EcoScreen assay using Chinese hamster ovary (CHO) cell line, hERα-HeLa9903, MDA-kb2, and GH3. Read More

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The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review.

Front Endocrinol (Lausanne) 2022 2;13:883827. Epub 2022 Jun 2.

Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Triclosan is an antibacterial agent suspected to disrupt the endocrine system. The aim of this study was to investigate the influence of triclosan on the human thyroid system through a systematic literature review of human studies.

Methods: Eligibility criteria and method of analysis were registered at Prospero (registration number: CRD42019120984) before a systematic search was conducted in Pubmed and Embase in October 2020. Read More

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Exploring the influence mechanism of dissolved organic matter on the bioavailability and thyroid hormone disrupting effect of zinc: A case study of effluents from galvanizing plants.

Ecotoxicol Environ Saf 2022 Jun 14;241:113747. Epub 2022 Jun 14.

Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address:

The effect of dissolved organic matter (DOM) on metal bioavailability and toxicity is a complex process. Effluents from galvanizing plants containing large amounts of DOM and Zn were selected to investigate the potential influence and mechanism of DOM on Zn bioavailability and its role in inducing thyroid hormone disrupting effects. Thyroid hormone disrupting effects were evaluated using a recombinant thyroid hormone receptor β gene yeast assay. Read More

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Gestational exposure to bisphenol A induces region-specific changes in brain metabolomic fingerprints in sheep.

Environ Int 2022 Jul 6;165:107336. Epub 2022 Jun 6.

Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.

Fetal brain development depends on maternofetal thyroid function. In rodents and sheep, perinatal BPA exposure is associated with maternal and/or fetal thyroid disruption and alterations in central nervous system development as demonstrated by metabolic modulations in the encephala of mice. We hypothesized that a gestational exposure to a low dose of BPA affects maternofetal thyroid function and fetal brain development in a region-specific manner. Read More

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Safety and toxicologic evaluation of Edible Pongamia Oil: A novel food ingredient.

Food Chem Toxicol 2022 Jun 10;166:113213. Epub 2022 Jun 10.

Terviva, Inc, 980 Atlantic Ave., STE 105, Alameda, CA, 94501, USA. Electronic address:

Edible Pongamia Oil (EPO) was evaluated in an acute oral toxicity study, GLP 14-Day and 90-Day repeated dose isocaloric dietary toxicity studies in rats, and in vitro Bacterial Reverse Mutation, and in vivo Mammalian Bone Marrow Chromosome Aberration genotoxicity studies for potential use as a food ingredient. In a non-GLP acute study, an LD > 5000 mg/kg was determined. Subacute 14-day repeated dose dietary administration of 0, 5, 10 and 15% oil revealed no adverse changes in clinical pathology, liver histology, body weight or weight gain, food consumption or food efficiency. Read More

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Effect of Acute Exposure to the Ionic Liquid 1-Methyl-3-octylimidazolium Chloride on the Embryonic Development and Larval Thyroid System of Zebrafish.

Animals (Basel) 2022 May 25;12(11). Epub 2022 May 25.

Henan International Joint Laboratory of Aquatic Toxicology and Health Protection, College of Life Science, Henan Normal University, Xinxiang 453007, China.

Previous studies have shown that ILs can induce toxicity in animals, plants, and cells. However, the effect of imidazolium-based ILs on the hypothalamus-pituitary-thyroid (HPT) axis of fish remains unknown. The present study aimed to evaluate the acute effect of [C8mim]Cl on the embryonic development and thyroid-controlled internal secretion system of zebrafish by determining the thyroid hormone level and the expression of HPT-related genes. Read More

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Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.

J Ethnopharmacol 2022 Jun 6;296:115443. Epub 2022 Jun 6.

Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Ethnopharmacological Relevance: Glycyrrhiza and sargassum are among the 18 incompatible medicaments according to traditional Chinese medicine (TCM) theory. Although it contains glycyrrhiza and sargassum, Haizao Yuhu decoction (HYD) is a classic prescription widely used as TCM to treat goiter. According to the Chinese Pharmacopoeia, glycyrrhiza is divided into three varieties: Glycyrrhiza uralensis Fish. Read More

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Bisphenol A Analogs Induce Cellular Dysfunction in Human Trophoblast Cells in a Thyroid Hormone Receptor-Dependent Manner: and Analyses.

Environ Sci Technol 2022 Jun 6. Epub 2022 Jun 6.

College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, P. R. China.

Bisphenol A (BPA) and its analogs are frequently detected in human daily necessities and environmental media. Placental thyroid hormone plays an important role in fetal development. Herein, we followed the adverse outcome pathway (AOP) to explore the toxic mechanisms of BPA and its analogs toward placental thyroid hormone receptor (TR). Read More

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Evaluation of human thyroid hormone receptor-antagonist activity in 691 chemical compounds using a yeast two-hybrid assay with Y190.

Data Brief 2022 Jun 21;42:108303. Epub 2022 May 21.

Health and Environmental Risk Division, National Institute for Environmental Studies, Japan.

The human thyroid receptor (hTR)-antagonist activities of 691 compounds were evaluated using a yeast two-hybrid assay with Y190 introduced hTRα and coactivator. In parallel, those YTOX tests were conducted to evaluate whether those compounds affected either antagonism or toxicity. This is the first report that focuses on the hTR-antagonist activity of many chemical compounds suspected to be endocrine disruptor. Read More

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Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines.

Appl In Vitro Toxicol 2021 Jun;7(2):39-49

Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States.

Introduction: Investigation of normal human thyroid function using culture systems is dependent on cells that recapitulate physiology of differentiated thyrocytes. Primary thyrocytes retain features of the native organ but have limited lifespan in culture. Immortalized thyrocytes offer an alternative if challenges maintaining phenotypic stability can be overcome to retain functional features of primary cells. Read More

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3,3',5-triiodo-l-thyronine inhibits drug-induced liver injury through activation of PPARα as revealed by network pharmacology and biological experimental verification.

Toxicol Appl Pharmacol 2022 Aug 2;448:116098. Epub 2022 Jun 2.

Key Laboratory of TCM-information Engineer of State Administration of TCM, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China. Electronic address:

Drug-induced liver injury (DILI) has increased in recent years, leading to acute liver failure. 3,3',5-triiodo-l-thyronine (T3) has been reported to exert a potent hepatoprotective effect. However, the mechanism and efficacy of T3 on DILI remain undocumented. Read More

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Ioxynil and diethylstilbestrol increase the risks of cardiovascular and thyroid dysfunction in zebrafish.

Sci Total Environ 2022 Sep 1;838(Pt 3):156386. Epub 2022 Jun 1.

Centre of Marine Sciences, University of Algarve, Faro, Portugal; Faculty of Medicine and Biomedical Sciences, University of the Algarve, Faro, Portugal; Algarve Biomedical Center-Research Institute (ABC-RI), University of Algarve, Faro, Portugal. Electronic address:

Endocrine disruption results from exposure to chemicals that alter the function of the endocrine system in animals. Chronic 60 days of exposure to a low dose (0.1 μM) of ioxynil (IOX) or diethylstilbestrol (DES) via food was used to determine the effects of these chemicals on the physiology of the heart and thyroid follicles in juvenile zebrafish. Read More

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September 2022

Alterations in the gut microbiota and its metabolic profile of PM exposure-induced thyroid dysfunction rats.

Sci Total Environ 2022 Sep 3;838(Pt 3):156402. Epub 2022 Jun 3.

Department of Environmental and Occupational Health, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China. Electronic address:

Fine particulate matter (PM) has drawn more and more interest due to its adverse effects on health. Thyroid has been demonstrated to be the key organ impacted by PM. However, the mechanisms for PM exposure-induced thyrotoxicity remain unclear. Read More

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September 2022

Hormonal profile changes induced by pesticide mixture exposure in female rats revealed by hair analysis.

Chemosphere 2022 Sep 26;303(Pt 2):135059. Epub 2022 May 26.

Human Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445, Strassen, Luxembourg. Electronic address:

Pesticide exposure has been associated with hormonal disruption in both animals and humans. However, there is limited knowledge of the combined effects of complex mixtures of pesticides on endogenous hormone levels. Here, we used hair analysis to assess the impact of a pesticide mixture comprising 19 components from multiple chemical classes at eight doses of 0-400 μg/kg body weight (bw) three times per week per component on concentrations of 36 steroid and thyroid hormones in female rats over a 90-day exposure period. Read More

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September 2022

Identification of combinations of endocrine disrupting chemicals in household chemical products that require mixture toxicity testing.

Ecotoxicol Environ Saf 2022 Jul 26;240:113677. Epub 2022 May 26.

Department of Occupational and Environmental Health, Yongin University, Yongin 17092, Republic of Korea. Electronic address:

People are exposed to various chemicals contained in consumer products for which the risks are poorly characterized. There is growing evidence that exposure to endocrine disrupting chemicals (EDCs) through product use potentially affects development, behavior, and reproduction. However, limited information is available about common combinations of chemicals based on their appearance and potential health effects. Read More

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Interaction of fluoride exposure and CREB1 gene polymorphisms on thyroid function in school-age children.

Chemosphere 2022 Sep 28;303(Pt 2):135156. Epub 2022 May 28.

Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:

Objectives: To evaluate the effects of CREB1 gene polymorphisms and long-term exposure to fluoride on thyroid function of children.

Study Design: A total of 424 children (including 226 boys and 198 girls) aged 7-12 years old were enrolled in Kaifeng, China by cross-sectional study in 2017. The concentrations of urinary fluoride (UF) and creatinine (UCr) were measured using fluoride ion-selective electrode assay and creatinine assay kit (picric acid method), respectively. Read More

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September 2022

Enantioselective bioaccumulation, oxidative stress, and thyroid disruption assessment of cis-metconazole enantiomers in zebrafish (Danio rerio).

Aquat Toxicol 2022 Jul 22;248:106205. Epub 2022 May 22.

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China. Electronic address:

Chiral triazole pesticides may cause enantioselectively adverse effects to non-target organisms. In this work, we employed zebrafish as an aquatic organism model to explore stereoselective acute toxicity, bioaccumulation, oxidative stress, and thyroid disruption of cis-metconazole enantiomers. The median lethal concentration values of (1S, 5R)-metconazole, (1R, 5S)-metconazole, and the mixture of them against zebrafish were 4. Read More

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Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study.

Environ Int 2022 Jul 21;165:107313. Epub 2022 May 21.

Department of Toxicology "Akademik Danilo Soldatović", University of Belgrade - Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address:

The main objective of this research was to conduct a dose-response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The study included 207 male participants from subjects of 5 different cohorts (patients with prostate, testicular, and pancreatic cancer, patients suffering from various thyroid and metabolic disorders, as well as healthy volunteers), enrolled from January 2019 to May 2021 at the Clinical Centre of Serbia in Belgrade, Serbia. Benchmark dose-response modeling analysis was performed with the PROAST software version 70. Read More

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Short-Term Exposure Effects of the Environmental Endocrine Disruptor Benzo(a)Pyrene on Thyroid Axis Function in Zebrafish.

Int J Mol Sci 2022 May 23;23(10). Epub 2022 May 23.

Lab of Endocrine and Metabolic Research, IRCCS Istituto Auxologico Italiano, 20100 Milan, Italy.

Benzo(a)Pyrene (BaP) is one of the most widespread polycyclic aromatic hydrocarbons (PAHs) with endocrine disrupting properties and carcinogenic effects. In the present study, we tested the effect of BaP on thyroid development and function, using zebrafish as a model system. Zebrafish embryos were treated with 50 nM BaP from 2. Read More

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Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System.

Int J Mol Sci 2022 May 20;23(10). Epub 2022 May 20.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro" (PROMISE), Section of Endocrinology, University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy.

There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has alarming adverse health effects through both hormone-direct and hormone-indirect pathways. Non-chemical agents, including physical agents such as artificial light, radiation, temperature, and stress exposure, are currently poorly investigated, even though they can seriously affect the endocrine system, by modulation of hormonal action. Read More

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Waterborne exposure to avobenzone and octinoxate induces thyroid endocrine disruption in wild-type and thrαa zebrafish larvae.

Ecotoxicology 2022 May 27. Epub 2022 May 27.

Department of Environmental Health, Graduate School at Yongin University, Yongin, 17092, Republic of Korea.

Avobenzone and octinoxate are frequently used as organic ultraviolet filters, and these chemicals are widely detected in water. This study evaluated the potential of avobenzone and octinoxate to disrupt thyroid endocrine system in wild-type and thyroid hormone receptor alpha a knockout (thrαa) zebrafish embryo/larvae. Following a 120 h exposure to various concentrations of avobenzone and octinoxate, larvae mortality and developmental toxicity in wild-type and thrαa fish were assessed. Read More

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The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats.

Toxicol Appl Pharmacol 2022 Jul 23;447:116085. Epub 2022 May 23.

Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States of America. Electronic address:

Ozone-induced lung injury/inflammation dissipates despite continued exposure for 3 or more days; however, the mechanisms of adaptation/habituation remain unclear. Since ozone effects are mediated through adrenal-derived stress hormones, which also regulate longevity of centrally-mediated stress response, we hypothesized that ozone-adaptation is linked to diminution of neuroendocrine stress-axes activation and glucocorticoid levels. Male Wistar-Kyoto-rats (12-week-old) were injected with vehicle or a therapeutically-relevant dexamethasone dose (0. Read More

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Higher free thyroxine associated with PFAS exposure in first trimester. The Odense Child Cohort.

Environ Res 2022 Sep 18;212(Pt D):113492. Epub 2022 May 18.

Department of Endocrinology, Odense University Hospital, Søndre Blvd. 29, 5000, Odense C, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000, Odense, Denmark.

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). Read More

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September 2022

mRNA-miRNA sequencing reveals mechanisms of 2,2'-dipyridyl disulfide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus).

Aquat Toxicol 2022 Jul 7;248:106191. Epub 2022 May 7.

College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, China. Electronic address:

This study was conducted to evaluate the thyroid-disrupting effects of 2,2'-dipyridyl disulfide using Japanese flounder (Paralichthys olivaceus) as an animal model and to reveal the underlying mechanisms from the perspective of miRNA-mRNA interactions. The results indicated that 2,2'-dipyridyl disulfide exposure decelerated the metamorphic progress of P. olivaceus, suggesting its thyroid-disrupting property as an antagonist. Read More

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IPPD-induced growth inhibition and its mechanism in zebrafish.

Ecotoxicol Environ Saf 2022 May 11;239:113614. Epub 2022 May 11.

Fishery Resources and Environmental Science Experimental Station of The Upper-Middle Reaches of Yangtze River (Ministry of Agriculture), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, Hubei 430223, China. Electronic address:

N-isopropyl-N-phenyl-1,4-phenylenediamine (IPPD) is used as a ubiquitous antioxidant worldwide, it is an additive in tire rubber easily discharged into the surrounding environment. At present, there is no study concerning the subacute toxicity of IPPD on fish. We used zebrafish embryos (2 h post-fertilization) exposed to IPPD for 5 days at concentrations of 0, 0. Read More

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Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function.

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

Epinephrine is the most abundant catecholamine hormone, produced by the nervous system and adrenal glands. Endocrine disruption of epinephrine synthesis, secretion and signaling is less studied than steroid and thyroid hormones. Dichlorodiphenyltrichloroethane (DDT) is recognized as one of the most prominent environmental contaminants with a long half-life. Read More

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Toxic Effects on Thyroid Gland of Male Adult Lizards () in Contact with PolyChlorinated Biphenyls (PCBs)-Contaminated Soil.

Int J Mol Sci 2022 Apr 26;23(9). Epub 2022 Apr 26.

Department of Biology, University of Naples "Federico II", 80126 Naples, Italy.

Skin exposure is considered a potentially significant but little-studied pathway for PolyChlorinated Biphenyls uptake in terrestrial reptiles. In this study, a native Italian lizard, , was exposed to PCBs-contaminated soil for 120 days. Tissues distribution of PCBs, thyroid hormone levels, and thyroid histo-physiopathology were examined. Read More

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Parental exposure to waterborne selenite induces transgenerational development toxicity in zebrafish offspring.

Chemosphere 2022 Sep 10;303(Pt 1):134838. Epub 2022 May 10.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China; Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Wuhan, 430070, People's Republic of China; Key Laboratory of Environment Correlative Dietology, Ministry of Education, Wuhan, 430070, People's Republic of China. Electronic address:

Excessive selenium (Se), especially selenite form exerts great toxicity to fish. Most studies have attached considerable attention to the adverse effects of Se on parental fish. However, the transgenerational toxicity of Se on fish has been rarely reported. Read More

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September 2022

Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ).

Toxicol Mech Methods 2022 Jun 21:1-16. Epub 2022 Jun 21.

College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.

Pyrroloquinoline quinone (PQQ), a potent coenzyme antioxidant naturally occurring in foods, has been demonstrated to protect brain cells by enhancing the expression of nerve growth factors (NGF) and NGF receptors, and suppressing the fibril formation and aggression of amyloid β. We developed mnemoPQQ, a novel PQQ disodium salt and assessed its safety in GLP compliant toxicity studies. Acute toxicity studies of mnemoPQQ in Wistar rats revealed that its LD was 1825- and 1410 mg/kg body weight (bw) in male and female rats, respectively, whereas its acute dermal LD was >2000 mg/kg bw. Read More

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Associations of exposure to metal and metal mixtures with thyroid hormones: Results from the NHANES 2007-2012.

Environ Res 2022 Sep 7;212(Pt C):113413. Epub 2022 May 7.

Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, 60612, USA; Chicago Center for Health and Environment (CACHET), University of Illinois at Chicago, 835 S. Wolcott, Chicago, IL, 60612, USA.

Background: Disrupted thyroid homeostasis plays a role in neurocognitive dysfunction and metabolic disorders. Since individuals are exposed to multiple metals simultaneously, it is important to assess the effects of metal mixtures on thyroid hormone status. This study aimed to investigate the associations of metal mixtures and individual metals with thyroid hormone levels. Read More

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September 2022