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    2806 results match your criteria Toxicity Thyroid Hormone

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    Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects.
    Drug Deliv Transl Res 2017 Nov 20. Epub 2017 Nov 20.
    Department of Pathology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
    Hydrocortisone (HC), topical glucocorticoid along with hydroxytyrosol (HT), and anti-microbial- and anti-oxidant-loaded chitosan nanoparticles (CSNPs) were prepared in large scale and analyzed for their adverse effects on healthy human skin followed by repeated applications. Ten subjects were randomized to receive test (HC-HT CSNPs) and vehicle samples (aqueous (AQ) cream). They were applied on the arms for 28 days, and transepidermal water loss (TEWL), erythema intensity, and irritation score were measured. Read More

    Evaluation on the thyroid disrupting mechanism of malathion in Fischer rat thyroid follicular cell line FRTL-5.
    Drug Chem Toxicol 2017 Nov 16:1-8. Epub 2017 Nov 16.
    c Department of Environmental and Occupational Medicine , West China School of Public Health, Sichuan University , Chengdu , China.
    Thyroid hormones are involved in many important physiological activities including regulation of energy metabolism, development of nervous system, maintenance of cerebral functions, and so on. Endocrine-disrupting chemicals (EDCs) that interfere with thyroid functions raise serious concerns due to their frequent misuse in areas where regulations are poorly implemented. In addition, chemicals that are originally regarded safe may now be considered as toxic with the development of life sciences. Read More

    Multiple bioanalytical method to reveal developmental biological responses in zebrafish embryos exposed to triclocarban.
    Chemosphere 2017 Nov 8;193:251-258. Epub 2017 Nov 8.
    School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
    Triclocarban (TCC) is a well-known antibacterial agent that is frequently detected in environmental, wildlife and human samples. The potential toxicological effects and action mechanism of TCC on vertebrate development has remained unclear. In the present study, we analyzed phenotypic alterations, thyroid hormone levels, thyroid hormone responsive genes, and proteomic profiles of zebrafish embryos after exposure to a series of concentrations of TCC from 6 h post-fertilization (hpf) to 120 hpf. Read More

    Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients.
    J BUON 2017 Sep-Oct;22(5):1240-1245
    University of Thessaly, School of Health Sciences, Faculty of Medicine, Larissa, Greece.
    Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors.

    Methods: The data were collected by relevant studies on PubMed and EMBASE. Read More

    Sex differences in ochratoxin a toxicity in F344 rats after 7 and 21 days of daily oral administration.
    Food Chem Toxicol 2017 Nov 7. Epub 2017 Nov 7.
    University of Navarra, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, c/Irunlarrea 1, 31008, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain. Electronic address:
    Ochratoxin A (OTA) is a potent renal carcinogen in male rats but not in females. The mechanisms underlying these differences are unknown. The sex-dependent response of F344 rats after a repeated OTA oral administration for 7 (0. Read More

    Clinical guidance for Radioiodine Refractory Differentiated Thyroid Cancer.
    Clin Endocrinol (Oxf) 2017 Nov 2. Epub 2017 Nov 2.
    Department of Diabetes, EndocrinologyMetabolism, Royal North Shore Hospital Sydney, Australia.
    Prognosis from differentiated thyroid cancer is worse when the disease becomes refractory to radioiodine. Until recently, treatment options have been limited to local therapies such as surgery and radiotherapy, but the recent availability of systemic therapies now provides some potential for disease control. Multi-targeted kinase inhibitors (TKIs) including lenvatinib and sorafenib have been shown to improve progression free survival in Phase III clinical trials, but are also associated with a spectrum of adverse effects. Read More

    Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework.
    Toxicol Sci 2017 Nov;160(1):57-73
    Toxicity Assessment Division.
    Adequate levels of thyroid hormone (TH) are needed for proper brain development, deficiencies may lead to adverse neurologic outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between developmental exposures and decline in serum TH resulting in neurodevelopmental impairment is poorly understood. The present study developed a quantitative adverse outcome pathway where serum thyroxin (T4) reduction following inhibition of thyroperoxidase in the thyroid gland are described and related to deficits in fetal brain TH and the development of a brain malformation, cortical heterotopia. Read More

    Flame retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) toxicity is attenuated by N-acetylcysteine in human kidney cells.
    Toxicol Rep 2017 17;4:260-264. Epub 2017 May 17.
    Department of Urology, University of California, San Francisco, CA, USA.
    Prolonged exposure to the flame retardants found in many household products and building materials is associated with adverse developmental, reproductive, and carcinogenic consequences. While these compounds have been studied in numerous epidemiological and animal models, less is known about the effects of flame retardant exposure on cell function. This study evaluated the toxicity of the commonly used fire retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) in cell line derived from the kidney, a major tissue target of organohalogen toxicity. Read More

    Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program.
    Environ Health Perspect 2017 Sep 1;125(9):096001. Epub 2017 Sep 1.
    Office of Chemical Safety and Pollution Prevention, U.S. Environmental Protection Agency , Washington, DC, USA.
    Background: The U.S. EPA's Endocrine Disruptor Screening Program (EDSP) screens and tests environmental chemicals for potential effects in estrogen, androgen, and thyroid hormone pathways, and it is one of the only regulatory programs designed around chemical mode of action. Read More

    Effects of sublethal Abamectin exposure on some hormonal profiles and testicular histopathology in male albino rats and the possible ameliorative role of Eruca sativa.
    Environ Sci Pollut Res Int 2017 Nov 15;24(31):24690-24697. Epub 2017 Sep 15.
    Zoology Department, Faculty of Science, Minia University, Minia, 61519, Egypt.
    The ameliorative role of Eruca sativa on some hormonal profile and testicular histopathology in male albino rats exposed to a sublethal dose of 1 mg/kg body weight (b.wt). Abamectin (Crater 3. Read More

    Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis.
    J Toxicol Sci 2017 ;42(5):605-613
    Graduate School of Biomedical and Health Science, Hiroshima University.
    A large number of chemicals are routinely detected in aquatic environments, and these chemicals may adversely affect aquatic organisms. Accurate risk assessment requires understanding drug-metabolizing systems in aquatic organisms because metabolism of these chemicals is a critical determinant of chemical bioaccumulation and related toxicity. In this study, we evaluated mRNA expression levels of nuclear receptors and drug-metabolizing enzymes as well as cytochrome P450 (CYP) activities in pro-metamorphic tadpoles, froglets, and adult frogs to determine how drug-metabolizing systems are altered at different life stages. Read More

    Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.
    J Biol Chem 2017 Oct 31;292(40):16605-16615. Epub 2017 Aug 31.
    From the Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience and
    SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary manganese toxicity. Patients have elevated manganese in the blood and brain and develop neurotoxicity. Read More

    Thyrotoxicity of arsenate and arsenite on juvenile mice at organism, subcellular, and gene levels under low exposure.
    Chemosphere 2017 Nov 10;186:580-587. Epub 2017 Aug 10.
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China; Soil and Water Science Department, University of Florida, Gainesville, FL 32611, USA. Electronic address:
    Arsenic contamination in drinking water is a worldwide issue, posing threat to human health. Arsenic is an endocrine system disruptor, however, limited information is available regarding its long-term effects on thyroid endocrine system at low exposure. In this study, we assessed the thyroid toxicity of arsenate (AsV) and arsenite (AsIII) at 10-100 μg L(-1) in juvenile mice after 8-week of exposure via drinking water. Read More

    Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism.
    World J Gastroenterol 2017 Jul;23(28):5246-5252
    Fernando Díaz-Fontenla, Marta Castillo-Pradillo, Arantxa Díaz-Gómez, Luis Ibañez-Samaniego, Rafael Bañares-Cañizares, Rita García-Martínez, Unidad de Hepatología, Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
    Hepatic encephalopathy (HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events (i.e. Read More

    Silver nanoparticles cause osmoregulatory impairment and oxidative stress in Caspian kutum (Rutilus kutum, Kamensky 1901).
    Environ Monit Assess 2017 Aug 11;189(9):448. Epub 2017 Aug 11.
    Department of Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
    Silver nanoparticles (AgNPs) are increasingly used in several industrial and household products because of their antibacterial and antifungal properties. Hence, there is an inevitable risk that these chemicals may end up in aquatic biotopes and have adverse effects on the fauna. In order to assess potential health effects on aquatic organisms, this study evaluated the effects of waterborne AgNP exposure for 7 days on a set of critical stress parameters in juvenile Caspian kutum (Rutilus kutum), an economically important fish in the Caspian Sea. Read More

    Antenatal/early postnatal hypothyroidism alters arterial tone regulation in 2-week-old rats.
    J Endocrinol 2017 Nov 9;235(2):137-151. Epub 2017 Aug 9.
    Institute for Biomedical ProblemsRussian Academy of Sciences, Moscow, Russia.
    The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal/early postnatal hypothyroidism would alter the activity of endothelial NO pathway and Rho-kinase pathway, which are specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7 ppm) in drinking water during gestation and 2 weeks after delivery, and their progeny had normal body weight but markedly reduced blood levels of thyroid hormones (ELISA). Read More

    Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo.
    Chemosphere 2017 Oct 19;185:1173-1180. Epub 2017 Jul 19.
    Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China. Electronic address:
    Synthetic pyrethroids (SPs) are one of the most widely used pesticides and frequently detected in the aquatic environment. Previous studies have shown that SPs posed high aquatic toxicity, but information on the developmental toxicity and endocrine disruption on zebrafish (Danio rerio) at environmentally relevant concentrations is limited. In this study, zebrafish embryos were employed to examine the adverse effects of λ-cyhalothrin (LCT), fenvalerate (FEN), and permethrin (PM) at 2. Read More

    Acute exposure to tris (2-butoxyethyl) phosphate (TBOEP) affects growth and development of embryo-larval zebrafish.
    Aquat Toxicol 2017 Oct 27;191:17-24. Epub 2017 Jul 27.
    College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
    Tris (2-butoxyethyl) phosphate (TBOEP), is used as a flame retardant worldwide. It is an additive in materials and can be easily discharged into the surrounding environment. There is evidence linking TBOEP exposure to abnormal development and growth in zebrafish embryos/larvae. Read More

    Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity.
    Environ Pollut 2017 Nov 25;230:981-988. Epub 2017 Jul 25.
    College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan 430070, China; Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, China; National Demonstration Center for Experimental Aquaculture Education, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
    Microcystin-LR is the most poisonous and commonly encountered hepatotoxin produced by cyanobacteria in an aquatic ecosystem, and it may cause thyroid dysfunction in fish. The present study aimed to reveal the effects of transgenerational toxicity of MCLR on the thyroid endocrine system under sub-chronic exposure conditions. Adult zebrafish (F0) were exposed to environmentally relevant concentrations (1, 5 and 25 μg/L) of MCLR for 45 days. Read More

    Does laser phototherapy influence the proliferation of myoepithelial cells in the salivary gland of hypothyroid rats?
    J Photochem Photobiol B 2017 Aug 12;173:681-685. Epub 2017 Jul 12.
    Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal University of Bahia, Salvador, Brazil. Electronic address:
    Thyroid hormones influence both development and growth of organs and tissues and guarantee metabolic demands that interfere with the quality of digestive secretions, including those of the salivary glands. Laser phototherapy - LPT can modulate various biological phenomena and its diverse effects permit the action on different cell types. The aim of this study was to evaluate the influence of laser phototherapy on myoepithelial cells of salivary glands of hypothyroid rats. Read More

    Melatonin as pleiotropic molecule with therapeutic potential for type 2 diabetes and cancer.
    Curr Med Chem 2017 Jul 18. Epub 2017 Jul 18.
    Department of Structural Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University of Lodz, Lodz. Poland.
    The incidence both of diabetes, particularly type 2 (T2DM), and cancer is increasing worldwide, making these diseases growing global health problem along with increasing healthcare expenditures. The current therapeutic approach for the treatment of these multifactorial diseases is far from satisfactory. Therefore, there is still considerable interest in searching new therapeutic strategies with the use of both natural and synthetic compounds exhibiting higher efficiency and lower toxicity compared to medicines used currently in clinical practice. Read More

    The safety of available treatments options for neuroendocrine tumors.
    Expert Opin Drug Saf 2017 Oct 20;16(10):1149-1161. Epub 2017 Jul 20.
    b Department of Clinical Medicine and Surgery , Federico II University , Naples , Italy.
    Introduction: Neuroendocrine neoplasms (NEN) represent a heterogeneous group of malignancies generally characterized by low proliferation and indolent course. However, about half of the newly diagnosed cases are metastatic and require long-term systemic therapies. Areas covered: This review revises the literature to summarize the current knowledge upon safety of all systemic treatment options available. Read More

    Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring.
    Aquat Toxicol 2017 Sep 23;190:46-52. Epub 2017 Jun 23.
    State Key Laboratory of Pollution Control and Resource Reuse and School of the Environment, Nanjing University, Nanjing, Jiangsu 210093, China. Electronic address:
    Decabromodiphenyl ether (BDE-209) was one of most widely-used polybrominated diphenyl ether (PBDE) flame retardants and is frequently detected in both abiotic and biotic samples from environment. However, knowledge of its transgenerational risks is limited. Here, 4-month-old zebrafish were exposed to various concentrations of BDE-209 (0, 3, 30 or 300μg/L) for 28days and spawned in clean water without BDE-209. Read More

    Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls.
    Environ Res 2017 10 3;158:350-357. Epub 2017 Jul 3.
    Department of Biology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway; Department of Arctic Technology, University Centre in Svalbard, NO 9171 Longyearbyen, Norway. Electronic address:
    The glaucous gull (Larus hyperboreus) is an arctic top predator and scavenger exposed to high levels of mixtures of organohalogenated contaminants (OHCs) of which many interfere with the thyroid hormone (TH) system. In the present study, we applied statistical modeling to investigate the potential combined influence of the mixture of chlorinated, brominated and perfluorinated organic compounds in plasma of glaucous gulls on their plasma TH concentrations. In females, there were significant negative associations between several organochlorinated compounds (OCs) and free thyroxin (FT4) and triiodothyronine (FT3), indicating additive negative effects on FT4 and FT3. Read More

    A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.
    Aquat Toxicol 2017 Sep 21;190:1-10. Epub 2017 Jun 21.
    Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis 95616-8519, USA. Electronic address:
    The essential role of thyroid hormone (TH) signaling in mammalian development warrants the examination of man-made chemicals for its disruption. Among vertebrate species, the molecular components of TH signaling are highly conserved, including the thyroid hormone receptors (TRs), their heterodimer binding partners the retinoid-X receptors (RXRs), and their DNA recognition sequences (TREs). This molecular conservation allows examination of potential TH disruption in the tractable, in vivo model system of amphibian metamorphosis. Read More

    Image analysis for TSH mRNA in situ hybridization in pituitary glands from rats with thyroid follicular cell hypertrophy after treatment with three different test compounds.
    Res Vet Sci 2017 Oct 11;114:313-321. Epub 2017 Jun 11.
    Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Switzerland.
    The goal of this in situ hybridization and image analysis technique is to study the effects of new pharmacological/chemical entities on the thyroid and pituitary gland in rats, reveal the pathogenesis of thyroid follicular cell hypertrophy and to retrospectively exclude the risk of thyroid tumor development in humans. In the present study, we describe the increase of thyroid-stimulating hormone- (TSH-) beta subunit mRNA in the pars distalis of the pituitary gland and the quantitative measurement of TSH mRNA positive cells from rats of three 4-week toxicity studies treated with three different test compounds inducing thyroid follicular cell and hepatocellular hypertrophy in rats. Compared to immunohistochemistry (IHC), in situ hybridization (ISH) for TSH was found to be more sensitive. Read More

    Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway.
    Toxicology 2017 Jul 20;387:10-16. Epub 2017 Jun 20.
    School of Public Health, Xuzhou Medical University, 209 Tong-Shan Road, Xuzhou, Jiangsu 221000, China. Electronic address:
    We have shown Bisphenol A (BPA) acts as an androgen receptor (AR) antagonist in the previous study. However, the mechanisms underlying anti-androgenic effects of BPA remain unclear. The objective of this study was to explore whether the AR signaling was involved in AR antagonism of BPA. Read More

    The cell biology of the thyroid-disrupting mechanism of dichlorodiphenyltrichloroethane (DDT).
    J Endocrinol Invest 2017 Jun 21. Epub 2017 Jun 21.
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
    Objective: Dichlorodiphenyltrichloroethane (DDT) is an organochlorine known for its pesticide properties and for its negative effects on human health. It was banned in most countries for its toxicity to the endocrine system, but due to its persistence at clinically relevant concentrations in both soil and animal tissues, DDT is still linked to several health and social problems.

    Methods: We have previously shown that DDT exposure is causally related to the extracellular release of vesicular organelles such as microvesicles and/or exosomes by using immunocytochemistry with gold-tagged antibodies and various fluorescent membrane markers. Read More

    Thiocyanate: a review and evaluation of the kinetics and the modes of action for thyroid hormone perturbations.
    Crit Rev Toxicol 2017 Aug 6;47(7):537-563. Epub 2017 Mar 6.
    a Division of Biochemical Toxicology , National Center for Toxicological Research, US Food and Drug Administration , Jefferson , AR , USA.
    Exposure of the population to thiocyanate is predominantly through the diet and cigarette smoke. Thiocyanate is a potential thyroid disruptor due to its capacity to inhibit the uptake of iodide by the thyroid. Thiocyanate also interacts with the enzymatic reactions associated with iodide organification and thyroid hormone synthesis. Read More

    Time-dependent inhibitory effects of Tris(1, 3-dichloro-2-propyl) phosphate on growth and transcription of genes involved in the GH/IGF axis, but not the HPT axis, in female zebrafish.
    Environ Pollut 2017 Oct 15;229:470-478. Epub 2017 Jun 15.
    College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China; Collbaorative Innovation Center for Efficient and Health Production of Fisheries in Hunan Province, Hunan, Changde 415000, China. Electronic address:
    Growth curves were used to determine sensitive exposure windows for evaluation of developmental toxicity of chemicals to zebrafish. Dose- and time-dependent effects on body mass, body length and expression of genes involved in the growth hormone/insulin-like growth factor (GH/IGF) axis and the hypothalamic-pituitary-thyroid (HPT) axis were examined after exposure to environmentally relevant concentrations of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP). Based on growth curves, zebrafish grew most rapidly between 60 and 90 days post fertilization (dpf). Read More

    Endocrine-disrupting activity of per- and polyfluoroalkyl substances: Exploring combined approaches of ligand and structure based modeling.
    Chemosphere 2017 Oct 9;184:514-523. Epub 2017 Jun 9.
    Interdisciplinary Center for Nanotoxicity, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, 39217, USA. Electronic address:
    Exposure to perfluorinated and polyfluoroalkyl substances (PFCs/PFASs), endocrine disrupting halogenated pollutants, has been linked to various diseases including thyroid toxicity in human populations across the globe. PFASs can compete with thyroxine (T4) for binding to the human thyroid hormone transport protein transthyretin (TTR) which may lead to reduce thyroid hormone levels leading to endocrine disrupting adverse effects. Environmental fate and endocrine-disrupting activity of PFASs has initiated several research projects, but the amount of experimental data available for these pollutants is limited. Read More

    Endemic goitre and hypothyroidism in an adult female patient dependent on total parenteral nutrition.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    Departments of Endocrinology.
    We present the case of a thirty-year-old female patient who was referred to the endocrinology team with an enlarging goitre and biochemical hypothyroidism. She had been dependent on total parenteral nutrition for the previous six years as a result of intestinal failure thought to be caused by possible underlying mitochondrial disease. The patient also suffers from a Desmin myopathy, and at present, the exact aetiology behind her intestinal failure is not certain. Read More

    A comprehensive review of regulatory test methods for endocrine adverse health effects.
    Crit Rev Toxicol 2017 Jul 15;47(6):433-481. Epub 2017 Feb 15.
    b Equiparent Consulting , Woodbridge , VA , USA.
    Development of new endocrine disruption-relevant test methods has been the subject of intensive research efforts for the past several decades, prompted in part by mandates in the 1996 Food Quality Protection Act (FQPA). While scientific understanding and test methods have advanced, questions remain on whether current scientific methods are capable of adequately addressing the complexities of the endocrine system for regulatory health and ecological risk assessments. The specific objective of this article is to perform a comprehensive, detailed evaluation of the adequacy of current test methods to inform regulatory risk assessments of whether a substance has the potential to perturb endocrine-related pathways resulting in human adverse effects. Read More

    Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats.
    Endocr Regul 2017 Apr;51(2):105-113
    Objective: We investigated the effects of hydroalcoholic extract of Nigella sativa (NS) on renal tissue oxidative damage associated with propylthiouracil (PTU)-induced hypothyroidism during neonatal and juvenile growth in rats.

    Methods: Pregnant rats were divided into five groups designated as: 1) control; 2) propylthiouracil (PTU); 3) PTU-NS100; 4) PTU-NS200, and 5) PTU-NS400. All mothers except the control group received 0. Read More

    Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer.
    Food Chem Toxicol 2017 Sep 9;107(Pt A):186-200. Epub 2017 Jun 9.
    Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, HECSB, Health Canada, Ottawa, Ontario, Canada. Electronic address:
    Acrylamide (AA) exposure in 2-year cancer bioassays leads to thyroid, but not liver, adenomas and adenocarcinomas in rats. Hypothesized modes of action (MOAs) include genotoxicity/mutagenicity, or thyroid hormone dysregulation. To examine the plausibility of these two or any alternative MOAs, RNA-sequencing was performed on the thyroids and livers of AA-exposed rats, in parallel with measurement of genotoxicity (blood micronucleus and Pig-a mutant frequency) and serum thyroid hormone levels, following the exposure of male Fischer 344/DuCrl rats to 0. Read More

    Maternal perchlorate exposure in pregnancy and altered birth outcomes.
    Environ Res 2017 10 9;158:72-81. Epub 2017 Jun 9.
    School of Public Health, University of California, Berkeley, CA, USA; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA. Electronic address:
    Background: At high medicinal doses perchlorate is known to decrease the production of thyroid hormone, a critical factor for fetal development. In a large and uniquely exposed cohort of pregnant women, we recently identified associations between environmental perchlorate exposures and decreased maternal thyroid hormone during pregnancy. Here, we investigate whether perchlorate might be associated with birthweight or preterm birth in the offspring of these women. Read More

    Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat.
    J Toxicol Environ Health A 2017 1;80(4):236-249. Epub 2017 Jun 1.
    a Endocrine Toxicology Branch, Toxicity Assessment Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.
    Triclosan (TCS), an antibacterial, has been shown to be an endocrine disruptor in the rat. Previously, subchronic TCS treatment to female rats was found to advance puberty and potentiate the effect of ethinyl estradiol (EE) on uterine growth when EE and TCS were co-administered prior to weaning. In the pubertal study, a decrease in serum thyroxine (T4) concentrations with no significant change in serum thyroid-stimulating hormone (TSH) was also observed. Read More

    Cytotoxic and genotoxic effects of (131) I and (60) Co in follicular thyroid cancer cell (WRO) with and without recombinant human thyroid-stimulating hormone treatment.
    Environ Mol Mutagen 2017 Jul 31;58(6):451-461. Epub 2017 May 31.
    Centro de Biotecnologia, Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes, 2242, CEP 05508-900, Caixa Postal 11049, Cidade Universitária, São Paulo, Brazil.
    Normally, differentiated thyroid cancer (DTC) tends to be biologically indolent, highly curable and has an excellent prognosis. However, the treatment may fail when the cancer has lost radioiodine avidity. The present study was carried out in order to evaluate the cytotoxic and genotoxic effects of (131) I and (60) Co and radioiodine uptake in WRO cells, derived from DTC, harboring the BRAF(V600E) mutation. Read More

    Contaminants and energy expenditure in an Arctic seabird: Organochlorine pesticides and perfluoroalkyl substances are associated with metabolic rate in a contrasted manner.
    Environ Res 2017 08 26;157:118-126. Epub 2017 May 26.
    Norwegian Polar Research Institute, Fram Centre, NO-9296 Tromsø, Norway.
    Basal metabolic rate (BMR), the minimal energetic cost of living in endotherms, is known to be influenced by thyroid hormones (THs) which are known to stimulate in vitro oxygen consumption of tissues in birds and mammals. Several environmental contaminants may act on energy expenditure through their thyroid hormone-disrupting properties. However, the effect of contaminants on BMR is still poorly documented for wildlife. Read More

    Polychlorinated Biphenyl-Related Alterations of the Expression of Essential Genes in Harbour Seals (Phoca vitulina) from Coastal Sites in Canada and the United States.
    Arch Environ Contam Toxicol 2017 Aug 20;73(2):310-321. Epub 2017 May 20.
    Ocean Pollution Research Program, Coastal Ocean Research Institute, Vancouver Aquarium Marine Science Centre, PO Box 3232, Vancouver, BC, V6B 3X8, Canada.
    As long-lived marine mammals found throughout the temperate coastal waters of the North Pacific and Atlantic Oceans, harbour seals (Phoca vitulina) have become an invaluable sentinel of food-web contamination. Their relatively high trophic position predisposes harbour seals to the accumulation of harmful levels of persistent organic pollutants (POPs). We obtained skin/blubber biopsy samples from live-captured young harbour seals from various sites in the northeastern Pacific (British Columbia, Canada, and Washington State, USA) as well as the northwestern Atlantic (Newfoundland and Quebec, Canada). Read More

    Evidence for bisphenol A-induced disruption of maternal thyroid homeostasis in the pregnant ewe at low level representative of human exposure.
    Chemosphere 2017 Sep 5;182:458-467. Epub 2017 May 5.
    Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France. Electronic address:
    Many uncertainties remain regarding the potential of bisphenol A (BPA) as a thyroid disruptor in mammals and the relevance of experimental data to humans. The relevance of the exposure schemes used in experimental in vivo studies is also a major source of uncertainty when analysing the risk of BPA exposure for human health. In this context, the goals of our study, conducted in an ovine model relevant to human gestation and thyroid physiologies, were to: 1) determine the equivalence of subcutaneous and dietary exposures and 2) determine if environmentally relevant doses of BPA can alter gestational and newborn thyroid functions. Read More

    Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptors.
    Environ Pollut 2017 Aug 10;227:306-313. Epub 2017 May 10.
    Hokkaido Institute of Public Health, Kita-19, Nishi-12, Kita-ku, Sapporo 060-0819, Japan.
    In recent years, some pigments and chemical products have been reported to contain polychlorinated biphenyl (PCB) congeners as unintentional byproducts, and these have also been detected in residential environments from indoor air and house dust. In this study, using in vitro reporter gene assays, we characterized the agonistic and antagonistic activities of a total of 25 PCB congeners contained in pigments (PCB-1 to -16, -20, -35, -40, -52, -56, -77, -101, -126, and -153) against five nuclear hormone receptors, (estrogen receptor (ER) α/β, glucocorticoid receptor (GR), androgen receptor (AR), thyroid hormone receptor (TR) α1) and aryl hydrocarbon receptor (AhR). In the ERα/β assays, 19 and 13 of the 25 PCBs tested showed ERα/β agonistic and/or antagonistic activities, respectively. Read More

    Alternative plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester, for blood containers with protective effects on red blood cells and improved cold resistance.
    J Biomed Mater Res B Appl Biomater 2017 May 13. Epub 2017 May 13.
    Division of Medical Devices, National Institute of Health Sciences, Tokyo, 158-8501, Japan.
    Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC-made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers. Read More

    Impaired swim bladder inflation in early life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid.
    Environ Toxicol Chem 2017 Nov 28;36(11):2942-2952. Epub 2017 Jun 28.
    Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA.
    Inflation of the posterior and/or anterior swim bladder is a process previously demonstrated to be regulated by thyroid hormones. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically active form, 3,5,3'-triiodothyronine (T3), would impact swim bladder inflation. Two experiments were conducted using a model deiodinase inhibitor, iopanoic acid (IOP). Read More

    Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.
    Toxicol Lett 2017 Jun 3;275:77-82. Epub 2017 May 3.
    Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, Olomouc, CZ-783 71, Czech Republic.
    Aryl hydrocarbon receptor (AhR) is a transcription factor, the activity of which is modulated by hormones including glucocorticoids and estrogens. In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on transcriptional activity of AhR and the expression of its target gene CYP1A1. Study was carried out in human hepatocellular carcinoma cells HepG2 and primary cultures of human hepatocytes (HH). Read More

    Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.
    J Biol Chem 2017 Jun 1;292(23):9760-9773. Epub 2017 May 1.
    From the Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience and
    Manganese is an essential metal that becomes toxic at elevated levels. Loss-of-function mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a heritable manganese metabolism disorder resulting in elevated manganese levels and parkinsonian-like movement deficits. The underlying disease mechanisms are unclear; therefore, treatment is challenging. Read More

    Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications.
    Ann Pediatr Endocrinol Metab 2017 Mar 31;22(1):6-14. Epub 2017 Mar 31.
    School of Public Health, Seoul National University, Seoul, Korea.
    Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Read More

    Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes.
    PLoS One 2017 24;12(4):e0175784. Epub 2017 Apr 24.
    Type 1 Diabetes Centre, Infectivology and Clinical Trials Area, Children's Hospital Bambino Gesù, Rome, Italy.
    Type 1 diabetes and thyroid disease are T cell-dependent autoimmune endocrinopathies. The standard substitutive administration of the deficient hormones does not halt the autoimmune process; therefore, development of immunotherapies aiming to preserve the residual hormonal cells, is of crucial importance. PTPN22 C1858T mutation encoding for the R620W lymphoid tyrosine phosphatase variant, plays a potential pathophysiological role in autoimmunity. Read More

    Thyroid disrupting pesticides impair the hypothalamic-pituitary-testicular axis of a wildlife bird, Amandava amandava.
    Reprod Toxicol 2017 Aug 19;71:32-41. Epub 2017 Apr 19.
    Department of Biology, University of Waseda, Tokyo, Japan.
    The effect of two thyroid disrupting pesticides (TDPs) mancozeb (MCZ) and imidacloprid (IMI) on the hypothalamic-pituitary-gonadal/testicular (HPG) axis of a seasonally breeding bird, Amandava amandava has been evaluated. Male birds (n=8/group) were exposed to each of the pesticide (0.25% LD50 of respective pesticide) as well as to their two equimixture doses (0. Read More

    Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.
    Toxicol Sci 2017 Jul;158(1):101-115
    Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, Iowa.
    Chiral polychlorinated biphenyl (PCB) congeners have been implicated by laboratory and epidemiological studies in PCB developmental neurotoxicity. These congeners are metabolized by cytochrome P450 (P450) enzymes to potentially neurotoxic hydroxylated metabolites (OH-PCBs). The present study explores the enantioselective disposition and toxicity of 2 environmentally relevant, neurotoxic PCB congeners and their OH-PCB metabolites in lactating mice and their offspring following dietary exposure of the dam. Read More

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