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    2851 results match your criteria Toxicity Thyroid Hormone

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    Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.
    Reprod Toxicol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States. Electronic address:
    There continues to be a need to develop in vivo high-throughput screening (HTS) and computational methods to screen chemicals for interaction with the estrogen, androgen, and thyroid pathways and as complements to in vitro HTS assays. This study explored the utility of an embryonic zebrafish HTS approach to identify and classify endocrine bioactivity using phenotypically-anchored transcriptome profiling. Transcriptome analysis was conducted on zebrafish embryos exposed to 25 estrogen-, androgen-, or thyroid-active chemicals at concentrations that elicited adverse malformations or mortality at 120 hours post-fertilization in 80% of animals exposed. Read More

    Endocrine Disruption Activity of 30-day Dietary Exposure to Decabromodiphenyl Ethane in Balb/C Mouse.
    Biomed Environ Sci 2018 Jan;31(1):12-22
    Institute of Health and Environmental Medicine, Academy Military Medical Sciences, Tianjin 300050, China.
    Objective: This study aimed to evaluate the hepatotoxicity, metabolic disturbance activity and endocrine disrupting activity of mice treated by Decabromodiphenyl ethane (DBDPE).

    Methods: In this study, Balb/C mice were treated orally by gavage with various doses of DBDPE. After 30 days of treatment, mice were sacrificed; blood, livers and thyroid glands were obtained, and hepatic microsomes were isolated. Read More

    Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae.
    Chemosphere 2018 Apr;197:353-361
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.
    Tetrabromobisphenol A (TBBPA), one of the most widely used brominated flame retardants (BFRs), has resulted in worldwide environmental contamination. TBBPA has been reported as a thyroid endocrine disruptor and a potential neurotoxicant. However, the underlying mechanism is still not clear. Read More

    Impacts of Salinity and Temperature on the Thyroidogenic Effects of the Biocide Diuron in Menidia beryllina.
    Environ Sci Technol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Environmental Sciences, University of California, Riverside , 900 University Avenue, Riverside, California 92521, United States.
    Diuron is a herbicide used in agricultural and urban settings and also as an antifouling agent. Recent studies have indicated sublethal responses of diuron in the endocrine system of fish and amphibians. Given the potential of climate change to also alter fish endocrinology, the combination of environmental stressors with diuron may contribute to its sublethal toxicity. Read More

    Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study.
    Toxicol Sci 2018 Jan 27. Epub 2018 Jan 27.
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA.
    Thyroid hormones (TH) are essential for brain development, but there exists few rodent models that link TH insufficiency to apical neurodevelopmental endpoints. We have previously described a structural anomaly, a heterotopia, in the brains of rats treated in utero with propylthiouracil (PTU). However, how the timing of an exposure relates to this birth defect is unknown. Read More

    Identification of hepatic thyroid hormone-responsive genes in neonatal rats: Potential targets for thyroid hormone-disrupting chemicals.
    Toxicol Lett 2018 Apr 2;286:48-53. Epub 2018 Feb 2.
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, Japan.
    There have been many concerns about the possible adverse effects of thyroid hormone-disrupting chemicals in the environment. Because thyroid hormones are essential for regulating the growth and differentiation of many tissues, disruption of thyroid hormones during the neonatal period of an organism might lead to permanent effects on that organism. We postulated that there are target genes that are sensitive to thyroid hormones particularly during the neonatal period and that would thus be susceptible to thyroid hormone-disrupting chemicals. Read More

    Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients.
    Endocr J 2018 Jan 11. Epub 2018 Jan 11.
    Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
    Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Read More

    Organophosphate triesters and selected metabolites enhance binding of thyroxine to human transthyretin in vitro.
    Toxicol Lett 2018 Mar 3;285:87-93. Epub 2018 Jan 3.
    Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University, Ottawa, Canada; Department of Biology, Carleton University, Ottawa, Canada. Electronic address:
    The toxicological properties of organophosphate (OP) triesters that are used as flame retardants and plasticizers are currently not well understood, though increasing evidence suggests they can affect the thyroid system. Perturbation of thyroid hormone (TH) transport is one mechanism of action that may affect thyroid function. The present study applied an in vitro competitive protein binding assay with thyroxine (T4) and human transthyretin (hTTR) transport protein to determine the potential for the OP triesters, TDCIPP (tris(1,3-dichloro-2-propyl) phosphate), TBOEP (tris(butoxyethyl) phosphate), TEP (triethyl phosphate), TPHP (triphenyl phosphate), p-OH-TPHP (para-hydroxy triphenyl phosphate), and the OP diester DPHP (diphenyl phosphate), to competitively displace T4 from hTTR. Read More

    Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats.
    Toxicol Lett 2018 Mar 2;285:81-86. Epub 2018 Jan 2.
    Consejo Nacional de Investigaciones Cientificas y Técnicas, Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, CABA, Argentina.
    Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Read More

    Efficacy, Safety, and Pharmacokinetics of Axitinib in Nasopharyngeal Carcinoma: A Preclinical and Phase II Correlative Study.
    Clin Cancer Res 2018 Jan 4. Epub 2018 Jan 4.
    Comprehensive Cancer Trials Unit, Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
    We hypothesized that axitinib is active with an improved safety profile in nasopharyngeal carcinoma (NPC).We evaluated axitinib in preclinical models of NPC and studied its efficacy in a phase II clinical trial in recurrent or metastatic NPC patients who progressed after at least one line of prior platinum-based chemotherapy. We excluded patients with local recurrence or vascular invasion. Read More

    A novel lactoferrin-modified stealth liposome for hepatoma-delivery of triiodothyronine.
    Int J Pharm 2018 Feb 30;537(1-2):257-267. Epub 2017 Dec 30.
    Università degli Studi di Cagliari, Dept. Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124, Cagliari, Italy. Electronic address:
    Triiodothyronine (T3), a thyroid hormone synthesized and secreted by the thyroid gland, plays an essential role in morphogenesis and differentiation through interaction with its nuclear receptors (TRs). However, there are increasing evidences for its role in hepatocellular carcinoma (HCC) suppression. The aim of this work was to develop an effective hepatocellular carcinoma targeting drug delivery system to improve T3 delivery to hepatic cancer cells as well as to reduce toxic side effects. Read More

    Male Reproductive Functions Disrupted by Pharmacological Agents.
    Adv Exp Med Biol 2017 ;1034:13-24
    Department of Urology, University of Kansas Medical Center, Kansas City, KS, USA.
    In this chapter, we review the male reproductive functions disrupted by medications. Medications can affect the hypothalamic-pituitary-gonad axis, acting as endocrine disrupting chemicals (EDCs). Disturbances may be directly at androgen receptors, modifying the activity of endogenous androgens at the target tissue, or may disrupt feedback loops at the hypothalamus or pituitary resulting in modification of gonadotropin release. Read More

    Screening the Toxcast Phase 1 Chemical Library For Inhibition of Deiodinase Type 1 Activity.
    Toxicol Sci 2017 Dec 7. Epub 2017 Dec 7.
    Mid-Continent Ecology Division, Duluth, MN, 55803, USA.
    Thyroid hormone (TH) homeostasis is dependent upon coordination of multiple key events including iodide uptake, hormone synthesis, metabolism and elimination, to maintain proper TH signaling. Deiodinase enzymes catalyze iodide release from THs to interconvert THs between active and inactive forms, and are integral to hormone metabolism. The activity of deiodinases has been identified as an important endpoint to include in the context of screening chemicals for thyroid hormone disruption. Read More

    Methamphetamine Use With Subsequent Thyrotoxicosis/Thyroid Storm, Agranulocytosis, and Modified Total Thyroidectomy: A Case Report.
    Clin Med Insights Ear Nose Throat 2017 17;10:1179550617741293. Epub 2017 Nov 17.
    Division of Otolaryngology, Department of Surgery, St. Joseph's Medical Hospital and Medical Center, Phoenix, AZ, USA.
    Thyroid storm is a rare, potentially lethal condition involving collapse of the hypothalamic-pituitary-thyroid feedback loop. Thyroid storm carries a significant mortality rate, thus requiring prompt identification and treatment. A 47-year-old woman presented to the emergency department complaining of palpitations, shortness of breath, and emesis for 24 hours after using methamphetamine. Read More

    Digital gene expression analysis in the gills of Ruditapes philippinarum exposed to short- and long-term exposures of ammonia nitrogen.
    Aquat Toxicol 2018 Jan 23;194:121-131. Epub 2017 Nov 23.
    Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, PR China. Electronic address:
    Previous study revealed severe toxic effects of ammonia nitrogen on Ruditapes philippinarum including lysosomal instability, disturbed metabolic profiles, gill tissues with damaged structure, and variation of neurotransmitter concentrations. However, the underlying molecular mechanism was not fully understood yet. In the present study, digital gene expression technology (DGE) was applied to globally screen the key genes and pathways involved in the responses to short- and long-term exposures of ammonia nitrogen. Read More

    Gestational 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure disrupts fetoplacental unit: Fetal thyroid-cytokines dysfunction.
    Life Sci 2018 Jan 21;192:213-220. Epub 2017 Nov 21.
    Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
    Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40μg/kgb. Read More

    Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects.
    Drug Deliv Transl Res 2017 Nov 20. Epub 2017 Nov 20.
    Department of Pathology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
    Hydrocortisone (HC), topical glucocorticoid along with hydroxytyrosol (HT), and anti-microbial- and anti-oxidant-loaded chitosan nanoparticles (CSNPs) were prepared in large scale and analyzed for their adverse effects on healthy human skin followed by repeated applications. Ten subjects were randomized to receive test (HC-HT CSNPs) and vehicle samples (aqueous (AQ) cream). They were applied on the arms for 28 days, and transepidermal water loss (TEWL), erythema intensity, and irritation score were measured. Read More

    Evaluation on the thyroid disrupting mechanism of malathion in Fischer rat thyroid follicular cell line FRTL-5.
    Drug Chem Toxicol 2017 Nov 16:1-8. Epub 2017 Nov 16.
    c Department of Environmental and Occupational Medicine , West China School of Public Health, Sichuan University , Chengdu , China.
    Thyroid hormones are involved in many important physiological activities including regulation of energy metabolism, development of nervous system, maintenance of cerebral functions, and so on. Endocrine-disrupting chemicals (EDCs) that interfere with thyroid functions raise serious concerns due to their frequent misuse in areas where regulations are poorly implemented. In addition, chemicals that are originally regarded safe may now be considered as toxic with the development of life sciences. Read More

    Multiple bioanalytical method to reveal developmental biological responses in zebrafish embryos exposed to triclocarban.
    Chemosphere 2018 Feb 8;193:251-258. Epub 2017 Nov 8.
    School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
    Triclocarban (TCC) is a well-known antibacterial agent that is frequently detected in environmental, wildlife and human samples. The potential toxicological effects and action mechanism of TCC on vertebrate development has remained unclear. In the present study, we analyzed phenotypic alterations, thyroid hormone levels, thyroid hormone responsive genes, and proteomic profiles of zebrafish embryos after exposure to a series of concentrations of TCC from 6 h post-fertilization (hpf) to 120 hpf. Read More

    Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients.
    J BUON 2017 Sep-Oct;22(5):1240-1245
    University of Thessaly, School of Health Sciences, Faculty of Medicine, Larissa, Greece.
    Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors.

    Methods: The data were collected by relevant studies on PubMed and EMBASE. Read More

    Sex differences in ochratoxin a toxicity in F344 rats after 7 and 21 days of daily oral administration.
    Food Chem Toxicol 2018 Jan 7;111:363-373. Epub 2017 Nov 7.
    University of Navarra, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, c/Irunlarrea 1, 31008, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain. Electronic address:
    Ochratoxin A (OTA) is a potent renal carcinogen in male rats but not in females. The mechanisms underlying these differences are unknown. The sex-dependent response of F344 rats after a repeated OTA oral administration for 7 (0. Read More

    Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish.
    Aquat Toxicol 2017 Dec 28;193:228-235. Epub 2017 Oct 28.
    Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, United States. Electronic address:
    Endocrine disrupting chemicals (EDCs) can alter thyroid function and adversely affect growth and development. Halogenated compounds, such as perfluorinated chemicals commonly used in food packaging, and brominated flame retardants used in a broad range of products from clothing to electronics, can act as thyroid disruptors. Due to the adverse effects of these compounds, there is a need for the development of safer next generation chemicals. Read More

    Clinical guidance for radioiodine refractory differentiated thyroid cancer.
    Clin Endocrinol (Oxf) 2017 Nov 2. Epub 2017 Nov 2.
    Department of Diabetes, Endocrinology & Metabolism, Royal North Shore Hospital Sydney, St Leonards, NSW, Australia.
    Prognosis from differentiated thyroid cancer is worse when the disease becomes refractory to radioiodine. Until recently, treatment options have been limited to local therapies such as surgery and radiotherapy, but the recent availability of systemic therapies now provides some potential for disease control. Multitargeted kinase inhibitors (TKIs) including lenvatinib and sorafenib have been shown to improve progression-free survival in phase III clinical trials, but are also associated with a spectrum of adverse effects. Read More

    Endocrine disruptors affect larval zebrafish behavior: Testing potential mechanisms and comparisons of behavioral sensitivity to alternative biomarkers.
    Aquat Toxicol 2017 Dec 6;193:128-135. Epub 2017 Oct 6.
    Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
    Larval zebrafish (Danio rerio) are a tool for assessing endocrine disruption during early development. Here, we investigated the extent to which a simple light/dark behavioral test at five days post fertilization could compliment current methods within the field. We exposed fertilized embryos to hormones (17β-estradiol, testosterone, dihydrotestosterone, 11-ketotestosterone, thyroxine, triiodothyronine, progesterone, and hydrocortisone) and other relevant compounds (17α ethinylestradiol, bisphenol A, bisphenol S, nonylphenol, flutamide, nilutamide, linuron, drospirenone, potassium perchlorate, mifepristone, and fadrozole) to screen for behavioral effects between 96 and 118h post fertilization (hpf). Read More

    Perfluoroalkyl substances, bone density, and cardio-metabolic risk factors in obese 8-12 year old children: A pilot study.
    Environ Res 2018 Jan 15;160:314-321. Epub 2017 Oct 15.
    Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York, Albany, NY 12201-0509, USA. Electronic address:
    Background And Objective: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. Read More

    Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus).
    Environ Pollut 2018 Jan 7;232:338-346. Epub 2017 Oct 7.
    Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing, 100085, China. Electronic address:
    Diflubenzuron (DFB) is a potential endocrine-disrupting chemical. However, its thyroid endocrine effect on reptiles has not been reported. In this study, immature lizards (Eremias argus) were exposed to 20 mg kgDFB once a week for 42 days through oral or dermal routes. Read More

    Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework.
    Toxicol Sci 2017 Nov;160(1):57-73
    Toxicity Assessment Division.
    Adequate levels of thyroid hormone (TH) are needed for proper brain development, deficiencies may lead to adverse neurologic outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between developmental exposures and decline in serum TH resulting in neurodevelopmental impairment is poorly understood. The present study developed a quantitative adverse outcome pathway where serum thyroxin (T4) reduction following inhibition of thyroperoxidase in the thyroid gland are described and related to deficits in fetal brain TH and the development of a brain malformation, cortical heterotopia. Read More

    Stereoselective degradation and thyroid endocrine disruption of lambda-cyhalothrin in lizards (Eremias argus) following oral exposure.
    Environ Pollut 2018 Jan 29;232:300-309. Epub 2017 Sep 29.
    Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China. Electronic address:
    The disturbance of the thyroid system and elimination of chiral pyrethroid pesticides with respect to enantioselectivity in reptiles have so far received limited attention by research. In this study, bioaccumulation, thyroid gland lesions, thyroid hormone levels, and hypothalamus-pituitary-thyroid axis-related gene expression in male Eremias argus were investigated after three weeks oral administration of lambda-cyhalothrin (LCT) enantiomers. In the lizard liver, the concentration of LCT was negatively correlated with the metabolite-3-phenoxybenzoic acid (PBA) level during 21 days of exposure. Read More

    Flame retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) toxicity is attenuated by-acetylcysteine in human kidney cells.
    Toxicol Rep 2017 17;4:260-264. Epub 2017 May 17.
    Department of Urology, University of California, San Francisco, CA, USA.
    Prolonged exposure to the flame retardants found in many household products and building materials is associated with adverse developmental, reproductive, and carcinogenic consequences. While these compounds have been studied in numerous epidemiological and animal models, less is known about the effects of flame retardant exposure on cell function. This study evaluated the toxicity of the commonly used fire retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) in cell line derived from the kidney, a major tissue target of organohalogen toxicity. Read More

    Competition and pesticide exposure affect development of invasive (Rhinella marina) and native (Fejervarya vittigera) rice paddy amphibian larvae.
    Ecotoxicology 2017 Dec 21;26(10):1293-1304. Epub 2017 Sep 21.
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, 86001, USA.
    Increased pesticide use in rice agricultural ecosystems may alter competitive interactions between invasive and native amphibian species. We conducted an experiment with two rice paddy amphibians found in Luzon, Philippines, the invasive cane toad (Rhinella marina) and the endemic Luzon wart frog (Fejervarya vittigera), to determine whether exposure to a common herbicide, butachlor, drives competitive interactions in favor of the invasive amphibian. Our results revealed that competition had a strong effect on the development of both species, but in opposing directions; Luzon wart frog tadpoles were smaller and developed slower than when raised alone, whereas cane toad tadpoles were larger and developed faster. Read More

    Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo.
    Int J Pharm 2017 Oct 19;532(1):581-594. Epub 2017 Sep 19.
    Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    In this study, we prepared tetraiodothyroacetic acid (tetrac) conjugated PEG-PLGA polymersomes for the targeted delivery of camptothecin to colon adenocarcinoma. Tetrac, which binds to integrin αβwith high affinity and specificity, was covalently conjugated to the surface of the PEGylated polymersomal formulation of camptothecin (CPT). The hydrodynamic and morphological properties of the prepared system were evaluated using TEM (transmission electron microscopy), SEM (scanning electron microscopy) and DLS (dynamic light scattering) experiments. Read More

    Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program.
    Environ Health Perspect 2017 09 1;125(9):096001. Epub 2017 Sep 1.
    Office of Chemical Safety and Pollution Prevention, U.S. Environmental Protection Agency , Washington, DC, USA.
    Background: The U.S. EPA's Endocrine Disruptor Screening Program (EDSP) screens and tests environmental chemicals for potential effects in estrogen, androgen, and thyroid hormone pathways, and it is one of the only regulatory programs designed around chemical mode of action. Read More

    Effects of sublethal Abamectin exposure on some hormonal profiles and testicular histopathology in male albino rats and the possible ameliorative role of Eruca sativa.
    Environ Sci Pollut Res Int 2017 Nov 15;24(31):24690-24697. Epub 2017 Sep 15.
    Zoology Department, Faculty of Science, Minia University, Minia, 61519, Egypt.
    The ameliorative role of Eruca sativa on some hormonal profile and testicular histopathology in male albino rats exposed to a sublethal dose of 1 mg/kg body weight (b.wt). Abamectin (Crater 3. Read More

    Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis.
    J Toxicol Sci 2017 ;42(5):605-613
    Graduate School of Biomedical and Health Science, Hiroshima University.
    A large number of chemicals are routinely detected in aquatic environments, and these chemicals may adversely affect aquatic organisms. Accurate risk assessment requires understanding drug-metabolizing systems in aquatic organisms because metabolism of these chemicals is a critical determinant of chemical bioaccumulation and related toxicity. In this study, we evaluated mRNA expression levels of nuclear receptors and drug-metabolizing enzymes as well as cytochrome P450 (CYP) activities in pro-metamorphic tadpoles, froglets, and adult frogs to determine how drug-metabolizing systems are altered at different life stages. Read More

    BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt.
    Environ Toxicol Pharmacol 2017 Dec 1;56:29-34. Epub 2017 Sep 1.
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, 33612, United States. Electronic address:
    PBDEs (polybrominated diphenyl ethers) are environmental pollutants that have been linked to the development of type 2 diabetes, however, the precise mechanisms are not clear. Particularly, their direct effect on insulin secretion is unknown. In this study, we show that two PBDE congeners, BDE-47 and BDE-85, potentiate glucose-stimulated insulin secretion (GSIS) in INS-1 832/13 cells. Read More

    Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.
    J Biol Chem 2017 10 31;292(40):16605-16615. Epub 2017 Aug 31.
    From the Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience and
    SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary manganese toxicity. Patients have elevated manganese in the blood and brain and develop neurotoxicity. Read More

    Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL.
    Aquat Toxicol 2017 Oct 19;191:175-188. Epub 2017 Aug 19.
    School of Life Sciences, The Chinese University of Hong Kong, Sha Tin, N.T., Hong Kong, China. Electronic address:
    Triclosan (TCS, 5-chloro-2-(2,4-dichlorophenoxy) phenol) is an antimicrobial agent widely used in personal care products. It has been detected in surface water, soil, aquatic species, and even humans. In this study, we used zebrafish (Danio rerio) as a model to test the hypothesis that TCS exhibits toxic effects by interacting with thyroid hormone receptor β (TRβ) and aryl hydrocarbon receptor (AhR) and by inducing the transcription of thyroid hormone (TH)-associated genes and affecting phase I and phase II enzymes. Read More

    Environmental exposure to a major urban wastewater effluent: Effects on the energy metabolism of northern pike.
    Aquat Toxicol 2017 Oct 4;191:131-140. Epub 2017 Aug 4.
    Centre de recherche en toxicologie de l'environnement (TOXEN), Département des sciences biologiques, Université du Québec à Montréal, C.P. 8888, Succursale Centre-ville, Montreal, QC H3C 3P8, Canada.
    Municipal wastewater effluents (MWWEs) consist of dynamic and complex mixtures of chemical and biological compounds that can alter the health of exposed aquatic organisms. Disturbance of energy metabolism has been reported in fish exposed to MWWEs. However, there is a scarcity of knowledge on the physiological events leading to perturbation of energy balance and thyroid regulation, and associated lipid metabolism. Read More

    Acute nitrite exposure alters the metabolism of thyroid hormones in grass carp (Ctenopharyngodon idellus).
    Chemosphere 2017 Nov 8;186:798-804. Epub 2017 Aug 8.
    College of Fisheries, Huazhong Agricultural University, Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan, 430070, PR China.
    Nitrite has the potential to disturb thyroid hormone homeostasis, but little is known about the underlying mechanisms. In the present study, juvenile grass carp (Ctenopharyngodon idellus) were exposed to various concentrations of nitrite (0, 0.5, 1, 4, and 16 mg/L, respectively). Read More

    Thyrotoxicity of arsenate and arsenite on juvenile mice at organism, subcellular, and gene levels under low exposure.
    Chemosphere 2017 Nov 10;186:580-587. Epub 2017 Aug 10.
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China; Soil and Water Science Department, University of Florida, Gainesville, FL 32611, USA. Electronic address:
    Arsenic contamination in drinking water is a worldwide issue, posing threat to human health. Arsenic is an endocrine system disruptor, however, limited information is available regarding its long-term effects on thyroid endocrine system at low exposure. In this study, we assessed the thyroid toxicity of arsenate (AsV) and arsenite (AsIII) at 10-100 μg Lin juvenile mice after 8-week of exposure via drinking water. Read More

    Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism.
    World J Gastroenterol 2017 Jul;23(28):5246-5252
    Fernando Díaz-Fontenla, Marta Castillo-Pradillo, Arantxa Díaz-Gómez, Luis Ibañez-Samaniego, Rafael Bañares-Cañizares, Rita García-Martínez, Unidad de Hepatología, Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
    Hepatic encephalopathy (HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events (., portosystemic shunt) and alternative diagnosis. Read More

    Silver nanoparticles cause osmoregulatory impairment and oxidative stress in Caspian kutum (Rutilus kutum, Kamensky 1901).
    Environ Monit Assess 2017 Aug 11;189(9):448. Epub 2017 Aug 11.
    Department of Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
    Silver nanoparticles (AgNPs) are increasingly used in several industrial and household products because of their antibacterial and antifungal properties. Hence, there is an inevitable risk that these chemicals may end up in aquatic biotopes and have adverse effects on the fauna. In order to assess potential health effects on aquatic organisms, this study evaluated the effects of waterborne AgNP exposure for 7 days on a set of critical stress parameters in juvenile Caspian kutum (Rutilus kutum), an economically important fish in the Caspian Sea. Read More

    Antenatal/early postnatal hypothyroidism alters arterial tone regulation in 2-week-old rats.
    J Endocrinol 2017 Nov 9;235(2):137-151. Epub 2017 Aug 9.
    Institute for Biomedical ProblemsRussian Academy of Sciences, Moscow, Russia.
    The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal/early postnatal hypothyroidism would alter the activity of endothelial NO pathway and Rho-kinase pathway, which are specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7 ppm) in drinking water during gestation and 2 weeks after delivery, and their progeny had normal body weight but markedly reduced blood levels of thyroid hormones (ELISA). Read More

    Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo.
    Chemosphere 2017 Oct 19;185:1173-1180. Epub 2017 Jul 19.
    Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China. Electronic address:
    Synthetic pyrethroids (SPs) are one of the most widely used pesticides and frequently detected in the aquatic environment. Previous studies have shown that SPs posed high aquatic toxicity, but information on the developmental toxicity and endocrine disruption on zebrafish (Danio rerio) at environmentally relevant concentrations is limited. In this study, zebrafish embryos were employed to examine the adverse effects of λ-cyhalothrin (LCT), fenvalerate (FEN), and permethrin (PM) at 2. Read More

    Acute exposure to tris (2-butoxyethyl) phosphate (TBOEP) affects growth and development of embryo-larval zebrafish.
    Aquat Toxicol 2017 Oct 27;191:17-24. Epub 2017 Jul 27.
    College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
    Tris (2-butoxyethyl) phosphate (TBOEP), is used as a flame retardant worldwide. It is an additive in materials and can be easily discharged into the surrounding environment. There is evidence linking TBOEP exposure to abnormal development and growth in zebrafish embryos/larvae. Read More

    Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity.
    Environ Pollut 2017 Nov 25;230:981-988. Epub 2017 Jul 25.
    College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan 430070, China; Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, China; National Demonstration Center for Experimental Aquaculture Education, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
    Microcystin-LR is the most poisonous and commonly encountered hepatotoxin produced by cyanobacteria in an aquatic ecosystem, and it may cause thyroid dysfunction in fish. The present study aimed to reveal the effects of transgenerational toxicity of MCLR on the thyroid endocrine system under sub-chronic exposure conditions. Adult zebrafish (F0) were exposed to environmentally relevant concentrations (1, 5 and 25 μg/L) of MCLR for 45 days. Read More

    Does laser phototherapy influence the proliferation of myoepithelial cells in the salivary gland of hypothyroid rats?
    J Photochem Photobiol B 2017 Aug 12;173:681-685. Epub 2017 Jul 12.
    Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal University of Bahia, Salvador, Brazil. Electronic address:
    Thyroid hormones influence both development and growth of organs and tissues and guarantee metabolic demands that interfere with the quality of digestive secretions, including those of the salivary glands. Laser phototherapy - LPT can modulate various biological phenomena and its diverse effects permit the action on different cell types. The aim of this study was to evaluate the influence of laser phototherapy on myoepithelial cells of salivary glands of hypothyroid rats. Read More

    The safety of available treatments options for neuroendocrine tumors.
    Expert Opin Drug Saf 2017 Oct 20;16(10):1149-1161. Epub 2017 Jul 20.
    b Department of Clinical Medicine and Surgery , Federico II University , Naples , Italy.
    Introduction: Neuroendocrine neoplasms (NEN) represent a heterogeneous group of malignancies generally characterized by low proliferation and indolent course. However, about half of the newly diagnosed cases are metastatic and require long-term systemic therapies. Areas covered: This review revises the literature to summarize the current knowledge upon safety of all systemic treatment options available. Read More

    Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring.
    Aquat Toxicol 2017 Sep 23;190:46-52. Epub 2017 Jun 23.
    State Key Laboratory of Pollution Control and Resource Reuse and School of the Environment, Nanjing University, Nanjing, Jiangsu 210093, China. Electronic address:
    Decabromodiphenyl ether (BDE-209) was one of most widely-used polybrominated diphenyl ether (PBDE) flame retardants and is frequently detected in both abiotic and biotic samples from environment. However, knowledge of its transgenerational risks is limited. Here, 4-month-old zebrafish were exposed to various concentrations of BDE-209 (0, 3, 30 or 300μg/L) for 28days and spawned in clean water without BDE-209. Read More

    Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls.
    Environ Res 2017 10 3;158:350-357. Epub 2017 Jul 3.
    Department of Biology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway; Department of Arctic Technology, University Centre in Svalbard, NO 9171 Longyearbyen, Norway. Electronic address:
    The glaucous gull (Larus hyperboreus) is an arctic top predator and scavenger exposed to high levels of mixtures of organohalogenated contaminants (OHCs) of which many interfere with the thyroid hormone (TH) system. In the present study, we applied statistical modeling to investigate the potential combined influence of the mixture of chlorinated, brominated and perfluorinated organic compounds in plasma of glaucous gulls on their plasma TH concentrations. In females, there were significant negative associations between several organochlorinated compounds (OCs) and free thyroxin (FT4) and triiodothyronine (FT3), indicating additive negative effects on FT4 and FT3. Read More

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