Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects.
- Muhammad Irfan Siddique,
- Haliza Katas,
- Adawiyah Jamil,
- Mohd Cairul Iqbal Mohd Amin,
- Shiow-Fern Ng,
- Mohd Hanif Zulfakar,
- Syed Maaz Nadeem
Drug Deliv Transl Res 2017 Nov 20. Epub 2017 Nov 20.
Department of Pathology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Hydrocortisone (HC), topical glucocorticoid along with hydroxytyrosol (HT), and anti-microbial- and anti-oxidant-loaded chitosan nanoparticles (CSNPs) were prepared in large scale and analyzed for their adverse effects on healthy human skin followed by repeated applications. Ten subjects were randomized to receive test (HC-HT CSNPs) and vehicle samples (aqueous (AQ) cream). They were applied on the arms for 28 days, and transepidermal water loss (TEWL), erythema intensity, and irritation score were measured. Read More