1,211 results match your criteria Toxicity Theophylline


A systematic review of phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets in China.

Medicine (Baltimore) 2018 Dec;97(51):e13689

Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Objective: In this study, we aimed to review the literature on phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets (CPEHTT).

Method: A literature search was performed in the following databases: WANFANG DATA, HowNet, National Library Reference and Consultation Alliance, Full-text Database of Foreign Medical Journals, PubMed and Ovid. The search terms were "Compound Phenytoin Sodium, ephedrine Hydrochloride and Theophylline Tablets," and "poisoning," or "toxicity," in Chinese and in English. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0007
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http://dx.doi.org/10.1097/MD.0000000000013689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320048PMC
December 2018
8 Reads

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.

Theranostics 2018 22;8(19):5246-5258. Epub 2018 Oct 22.

Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China.

The role of small heterodimer partner (SHP) in regulation of xenobiotic detoxification remains elusive. Here, we uncover a critical role for SHP in circadian regulation of cytochromes P450 (CYPs) and drug-induced hepatotoxicity. The mRNA and protein levels of CYPs in the livers of wild-type and SHP mice were measured by quantitative real-time polymerase chain reaction and Western blotting, respectively. Read More

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http://www.thno.org/v08p5246.htm
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http://dx.doi.org/10.7150/thno.28676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276094PMC
October 2018
10 Reads

A Three-Dimensional Organoid Culture Model to Assess the Influence of Chemicals on Morphogenetic Fusion.

Toxicol Sci 2018 Dec;166(2):394-408

Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711.

Embryologic development involves cell differentiation and organization events that are unique to each tissue and organ and are susceptible to developmental toxicants. Animal models are the gold standard for identifying putative teratogens, but the limited throughput of developmental toxicological studies in animals coupled with the limited concordance between animal and human teratogenicity motivates a different approach. In vitro organoid models can mimic the three-dimensional (3D) morphogenesis of developing tissues and can thus be useful tools for studying developmental toxicology. Read More

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http://dx.doi.org/10.1093/toxsci/kfy207DOI Listing
December 2018
2 Reads

Investigation of using pectin and chitosan as natural excipients in pellet formulation.

Int J Biol Macromol 2018 Dec 27;120(Pt A):1208-1215. Epub 2018 Aug 27.

Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

This study aimed to evaluate the potential of applying pectin and chitosan polysaccharides in pellet formulation. These biopolymers have advantages such as biocompatibility, low toxicity, low price and easy processing which make them interesting candidates for drug delivery purposes. Careful control of pellet porosity is essential to achieve an appropriate drug release profile. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.08.129DOI Listing
December 2018
5 Reads

Synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and PARP, HMGB1, Bcl-2 family mediated apoptosis in MDA-MB-231 breast cancer cells.

Biomed Pharmacother 2018 Oct 11;106:858-867. Epub 2018 Jul 11.

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Berberine, is a plant alkaloid, proved to have anticancer effect on various cancers. Theophylline (TH), a natural product, is widely used in the treatment of respiratory difficulties. The present study designed to elucidate the effects of theophylline and berberine combination on breast cancer cells cytotoxicity, gene expression and cell cycle. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183292
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http://dx.doi.org/10.1016/j.biopha.2018.07.019DOI Listing
October 2018
25 Reads

Rare Case of Theophylline Toxicity due to Influenza A Infection in an Adult With Asthma.

Am J Ther 2018 Jul 10. Epub 2018 Jul 10.

Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH.

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http://Insights.ovid.com/crossref?an=00045391-900000000-9857
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http://dx.doi.org/10.1097/MJT.00000000000008177DOI Listing
July 2018
4 Reads

Theophylline toxicity: An old poisoning for a new generation of physicians.

Turk J Emerg Med 2018 Mar 5;18(1):37-39. Epub 2018 Jan 5.

Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

A healthy 4-year-old female presented to the emergency department for vomiting and diarrhea. She was diagnosed with a urinary tract infection, treated with antibiotics and anti-emetics and discharged. Within four hours, her symptoms recurred, followed by decreasing responsiveness and seizures. Read More

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http://dx.doi.org/10.1016/j.tjem.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009804PMC
March 2018
18 Reads

No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.

Pediatr Crit Care Med 2018 Aug;19(8):e425-e432

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Penn State University College of Medicine, Hershey, PA.

Objectives: To determine the relationship between theophylline trough levels and urine output in critically ill children administered aminophylline as adjunctive diuretic therapy.

Design: Retrospective cohort study.

Setting: The PICU of a tertiary care children's hospital. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080883PMC
August 2018
3 Reads

Dose-dependent effects of adenosine antagonists on tacrine-induced tremulous jaw movements.

Eur J Pharmacol 2018 Aug 6;833:364-369. Epub 2018 Jun 6.

California State University, Fullerton Department of Psychology, 800 N. State College Blvd., Fullerton, CA 92831, United States. Electronic address:

The present study examines the effect of three adenosine receptor antagonists on tremulous jaw movements (TJMs), an animal model of tremor. Forty-five rats were pre-treated with one adenosine antagonist: caffeine (0.0, 5. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.06.004DOI Listing
August 2018
2 Reads

[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].

Yakugaku Zasshi 2018 ;138(6):809-813

Graduate School of Pharmaceutical Sciences, The University of Tokyo.

 During the preclinical research period of drug development, animal testing is widely used to help screen out a drug's dangerous side effects. However, it remains difficult to predict side effects within the central nervous system. Here, we introduce a machine learning-based in vitro system designed to detect seizure-inducing side effects before clinical trial. Read More

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https://www.jstage.jst.go.jp/article/yakushi/138/6/138_17-00
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http://dx.doi.org/10.1248/yakushi.17-00213-1DOI Listing
August 2018
26 Reads

Sorbitol production and optimization of photosynthetic supply in the cyanobacterium Synechocystis PCC 6803.

J Biotechnol 2018 Jun 21;276-277:25-33. Epub 2018 Apr 21.

Department of Life Sciences (Biolgy), Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. Electronic address:

Biochemicals production is a major theme in the application of photosynthesis to address global warming and organic-resource problems. Among biochemicals, sugar alcohols have attracted research attention because they are directly derived from two photosynthetic products, sugars and reductants. Here, we produced sorbitol photosynthetically by using cyanobacteria and modified the supply of its substrates through genetic engineering. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2018.04.004DOI Listing
June 2018
8 Reads

Engineering riboswitch in L. major: From prediction to conceptualization.

Int J Biol Macromol 2018 Aug 12;115:98-105. Epub 2018 Apr 12.

Computational and Systems Biology Lab, National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune 411007, Maharashtra, India. Electronic address:

Post-transcriptional gene regulation is a vital process to regulate expression of the key genes in the eukaryotic cell. Such processes are essential for pathogens which reside inside the host cell. One such pathogen is Leishmania major, which causes cutaneous leishmaniasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183094
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http://dx.doi.org/10.1016/j.ijbiomac.2018.04.031DOI Listing
August 2018
20 Reads

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations.

Crit Rev Food Sci Nutr 2018 Apr 6:1-29. Epub 2018 Apr 6.

d University of Beira Interior (UBI) , Covilhã , Portugal.

Methylated xanthines (methylxanthines) are available from a significant number of different botanical species. They are ordinarily included in daily diet, in many extremely common beverages and foods. Caffeine, theophylline and theobromine are the main methylxanthines available from natural sources. Read More

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http://dx.doi.org/10.1080/10408398.2018.1461607DOI Listing
April 2018
17 Reads

Regulatory respiratory data refinement with reduced animal usage.

J Pharmacol Toxicol Methods 2018 Sep - Oct;93:69-74. Epub 2018 Mar 23.

Charles River, Safety Pharmacology, Elphinstone Research Centre, Tranent, Edinburgh EH33 2NE, United Kingdom.

Introduction: Assessment of effects of potential drug candidates on the respiratory system is part of the regulatory preclinical safety assessment conducted prior to first in human trials (FTIH). Commonly, this is carried out utilizing head out plethysmography (HOP) or whole body plethysmography (WBP) which record only ventilatory parameters. When dosing via the inhaled route a more thorough respiratory assessment, including a direct measure of airway mechanics, is desirable. Read More

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http://dx.doi.org/10.1016/j.vascn.2018.03.005DOI Listing
January 2019
6 Reads

Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity.

Eur J Med Chem 2018 Apr 27;150:307-333. Epub 2018 Feb 27.

National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland. Electronic address:

Three out of 16 newly synthesized 1,3-dimethylxanthine derivatives (proxyphylline analogues) exhibited consistencies between antifungal and anticancer properties. Proxyphylline possessing 1-(10H-phenothiazin-10-yl)propan-2-yl (6) and polybrominated benzimidazole (41) or benzotriazole moiety (42) remained selectively cidal against Candida albicans (lg R ≥ 3 at conc. of 31, 36 and 20 μM, respectively) however not against normal mammalian Vero cell line in vitro (IC ≥ 280 μM) and Galleria mellonella in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183021
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http://dx.doi.org/10.1016/j.ejmech.2018.02.077DOI Listing
April 2018
9 Reads

STUDIES OF NEW PURINE DERIVATIVES WITH ACETIC ACID MOIETY IN HUMAN KERATINOCYTES.

Acta Pol Pharm 2017 Jan;74(1):111-117

Recently we described a group of purine derivatives based on theophylline structure with acetic acid moiety. Studies in a group of these compounds demonstrated their analgesic and anti-inflammatory properties. Taking into account wide spectrum of theophylline derivatives activity and searching for their new properties. Read More

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January 2017
5 Reads

Intercalated theophylline-smectite hybrid for pH-mediated delivery.

Drug Deliv Transl Res 2018 Dec;8(6):1781-1789

Faculty of Engineering and Science, University of Greenwich, Chatham Maritime, Chatham, Kent, ME4 4TB, UK.

On the basis of their large specific surface areas, high adsorption and cation exchange capacities, swelling potential and low toxicity, natural smectite clays are attractive substrates for the gastric protection of neutral and cationic drugs. Theophylline is an amphoteric xanthine derivative that is widely used as a bronchodilator in the treatment of asthma and chronic obstructive pulmonary disease. This study considers the in vitro uptake and release characteristics of the binary theophylline-smectite system. Read More

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http://dx.doi.org/10.1007/s13346-018-0478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280968PMC
December 2018
5 Reads

A highly sensitive gold nanoparticle-based electrochemical aptasensor for theophylline detection.

Anal Chim Acta 2018 Jan 9;999:54-59. Epub 2017 Nov 9.

CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, PR China. Electronic address:

Theophylline is a common bronchodilator for the treatment of diseases like asthma, bronchitis and emphysema. However, it should be strictly used and monitored due to its toxicity when the concentration is above certain levels. In this work, an electrochemical biosensor for theophylline detection is proposed by recognition of RNA aptamer and gold nanoparticle (AuNP)-based amplification technique. Read More

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http://dx.doi.org/10.1016/j.aca.2017.10.039DOI Listing
January 2018
15 Reads

Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos.

BMC Pharmacol Toxicol 2017 11 15;18(1):72. Epub 2017 Nov 15.

Department of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11, 25123, Brescia, Italy.

Background: Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline.

Methods: Microinjections of the eight methylxanthines were performed in 1-2 cell stage zebrafish embryos and the general toxicity and cardiovascular effects were analyzed at different time points. Read More

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http://dx.doi.org/10.1186/s40360-017-0179-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688754PMC
November 2017
17 Reads

Steroid sparing effects of doxofylline.

Pulm Pharmacol Ther 2018 02 16;48:1-4. Epub 2017 Oct 16.

Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, UK.

Glucocorticosteroids are widely used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). However, there are growing concerns about the side effect profile of this class of drug, particularly an increased risk of pneumonia. Over the last two decades there have been many attempts to find drugs to allow a reduction of glucocorticosteroids, including xanthines such as theophylline. Read More

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http://dx.doi.org/10.1016/j.pupt.2017.10.008DOI Listing
February 2018
1 Read

Prevention of isoniazid toxicity by NAT2 genotyping in Senegalese tuberculosis patients.

Toxicol Rep 2016 17;3:826-831. Epub 2016 Oct 17.

Laboratoire de Toxicologie, Centre de Biologie Pathologie, Centre Hospitalier Régional et Universitaire, Lille, France.

Isoniazid (INH), recommended by WHO (World Health Organization) in the treatment of tuberculosis (TB), is metabolized primarily by the genetically polymorphic -acetyltransferase 2 (NAT2) enzyme. The human population is divided into three different phenotypic groups according to acetylation rate: slow, intermediate, and fast acetylators. The objective of this study was to explore the relationship between NAT2 genotypes and the serum concentrations of INH. Read More

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http://dx.doi.org/10.1016/j.toxrep.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5616082PMC
October 2016
10 Reads

Identification of some novel xanthine-based derivatives with bronchodilator activity.

Future Med Chem 2017 10 5;9(15):1731-1747. Epub 2017 Sep 5.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Aim: The discovery of new bronchodilators with higher efficacy than theophylline is an important issue for asthmatic patients.

Materials & Methods: Theophylline 2, 8-bromotheophylline 4 and theobromine 6 were reacted with different 2/3-chloro-N-phenylacetamides 1a-d or their propanamide analogs 1e-g to obtain 3a-g, 5a-g and 7a-g, respectively. The target compounds were screened for their in vitro bronchodilator activity using isolated guinea pig tracheal rings precontracted with histamine and compared with their precursors. Read More

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http://dx.doi.org/10.4155/fmc-2017-0092DOI Listing
October 2017
19 Reads

Atrazine suppresses FSH-induced steroidogenesis and LH-dependent expression of ovulatory genes through PDE-cAMP signaling pathway in human cumulus granulosa cells.

Mol Cell Endocrinol 2018 02 30;461:79-88. Epub 2017 Aug 30.

Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Serbia.

Atrazine (ATR) alters female reproductive functions in different animal species. Here, we analyzed whether ATR disturbs steroidogenic and ovulatory processes in hormone-stimulated human cumulus granulosa cells and mechanism of its action. Results showed that treatment of human cumulus granulosa cells with 20 μM ATR for 48 h resulted in lower FSH-stimulated estradiol and progesterone production. Read More

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http://dx.doi.org/10.1016/j.mce.2017.08.015DOI Listing
February 2018
4 Reads

Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.

Environ Health Perspect 2017 08 4;125(8):087004. Epub 2017 Aug 4.

IRSET INSERM UMR1085 , Rennes, France.

Background: Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis maldescent, malformations of the genitalia at birth, and poor semen quality later in life.

Objectives: Our aim was to investigate whether chemicals can act together to disrupt androgen production in human fetal testis explants and to evaluate the importance of mixture effects when characterizing the hazard of individual chemicals. Read More

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http://dx.doi.org/10.1289/EHP1014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783658PMC
August 2017
19 Reads

Xylan-Modified-Based Hydrogels with Temperature/pH Dual Sensitivity and Controllable Drug Delivery Behavior.

Materials (Basel) 2017 Mar 16;10(3). Epub 2017 Mar 16.

Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.

Among the natural macromolecules potentially used as the scaffold material in hydrogels, xylan has aroused great interest in many fields because of its biocompatibility, low toxicity, and biodegradability. In this work, new pH and thermoresponsive hydrogels were prepared by the cross-linking polymerization of maleic anhydride-modified xylan (MAHX) with -isopropylacrylamide (NIPAm) and acrylic acid (AA) under UV irradiation to form MAHX--P(NIPAm-co-AA) hydrogels. The pore volume, the mechanical properties, and the release rate for drugs of hydrogels could be controlled by the degree of substitution of MAHX. Read More

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http://dx.doi.org/10.3390/ma10030304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503382PMC
March 2017
23 Reads

Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.

J Med Food 2017 Aug 28;20(8):812-819. Epub 2017 Jul 28.

2 Department of Food Science and Technology, Kongju National University , Yesan, Korea.

Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy. We observed that the luteolin peak decreased simultaneously with the appearance of new radiolytic peaks, using high-performance liquid chromatography (HPLC). The highest new radiolytic peak (GLM) of radiolytic product in gamma-irradiated luteolin was observed at a dose of 70 kGy, and the GLM was identified by nuclear magnetic resonance and high-performance-liquid-chromatography-quadrupole-time-of-flight (HPLC-Q-TOF) mass spectrometry. Read More

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http://dx.doi.org/10.1089/jmf.2016.3890DOI Listing
August 2017
20 Reads

Possible mechanisms involved in the anti-nociceptive effects of hydro-ethanolic leaf extract of Ziziphus abyssinica.

Pharm Biol 2017 Dec;55(1):1962-1971

a Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences , Kwame Nkrumah University of Science and Technology , Kumasi , Ghana.

Context: Various parts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) have been used in Ghanaian and African traditional medicine as an analgesic. Read More

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http://dx.doi.org/10.1080/13880209.2017.1355927DOI Listing
December 2017
20 Reads

Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery.

Pharm Res 2017 Oct 29;34(10):2097-2108. Epub 2017 Jun 29.

Skin Barrier Research Group,, Charles University, Faculty of Pharmacy in Hradec Králové,, Akademika Heyrovského 1203,, 50005, Hradec Králové, Czech Republic.

Purpose: To study new skin penetration/permeation enhancers based on amphiphilic galactose derivatives.

Methods: Two series of alkyl and alkenyl galactosides were synthesized and evaluated for their enhancing effect on transdermal/topical delivery of theophylline (TH), hydrocortisone (HC) and cidofovir (CDV), reversibility of their effects on transepidermal water loss (TEWL) and skin impedance, interaction with the stratum corneum using infrared spectroscopy, and cytotoxicity on keratinocytes and fibroblasts.

Results: Initial evaluation identified 1-(α-D-galactopyranosyl)-(2E)-pentadec-2-ene A15 as a highly potent enhancer - it increased TH and HC flux through human skin 8. Read More

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http://dx.doi.org/10.1007/s11095-017-2214-3DOI Listing
October 2017
32 Reads

Photocatalytic interaction of aminophylline-riboflavin leads to ROS-mediated DNA damage and cell death: A novel phototherapeutic mechanism for cancer.

IUBMB Life 2017 08 21;69(8):611-622. Epub 2017 Jun 21.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

The accompanied tissue devastation and systemic toxicity of chemotherapy has shifted the quest for having an effective and palliative cancer therapy towards photodynamic therapy (PDT). Riboflavin (Rf), an essential micronutrient is emerging as a potent tool of PDT, due to its excellent photosensitizing properties. It can be used as an efficient adjuvant for various anticancer drugs. Read More

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http://dx.doi.org/10.1002/iub.1643DOI Listing
August 2017
5 Reads

Update on the renal toxicity of iodinated contrast drugs used in clinical medicine.

Drug Healthc Patient Saf 2017 22;9:25-37. Epub 2017 May 22.

Renal Unit, Department of Health Sciences.

An important side effect of diagnostic contrast drugs is contrast-induced acute kidney injury (CI-AKI; a sudden decrease in renal function) occurring 48-72 hours after injection of a contrast drug that cannot be attributed to other causes. Its existence has recently been challenged, because of some retrospective studies in which the incidence of AKI was not different between subjects who received a contrast drug and those who did not, even using propensity score matching to prevent selection bias. For some authors, only patients with estimated glomerular filtration rate <30 mL/min/1. Read More

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http://dx.doi.org/10.2147/DHPS.S122207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447694PMC
May 2017
40 Reads

Comparative Efficacy and Safety of Caffeine and Aminophylline for Apnea of Prematurity in Preterm (≤34 weeks) Neonates: A Randomized Controlled Trial.

Indian Pediatr 2017 Apr;54(4):279-283

Departments of Pediatrics and *Community Medicine, Women and Child block, Kasturba Hospital, Manipal. Correspondence to: Dr Leslie Edward Simon Lewis, Professor and Unit Head, Neonatal Intensive Care Unit, Department of Pediatrics, Kasturba Hospital, Manipal University Manipal 576 104, India.

Objective: To compare the efficacy and safety of standard doses of Caffeine and Aminophylline for Apnea of prematurity.

Study Design: Randomized controlled trial.

Setting: Tertiary-care referral centre and a teaching institution in Southern India. Read More

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April 2017
50 Reads

A case of life-threatening supraventricular tachycardia storm associated with theophylline toxicity.

J Cardiol Cases 2017 Apr 6;15(4):125-128. Epub 2017 Mar 6.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Okayama, Japan.

A 76-year-old man taking theophylline was admitted to our hospital with congestive heart failure and supraventricular tachycardia (SVT). After admission, he developed cardiogenic shock as a result of SVT storm, which was refractory to medical treatment including adenosine and electrical cardioversion. The serum theophylline concentration at admission was identified as toxic. Read More

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http://dx.doi.org/10.1016/j.jccase.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135038PMC
April 2017
3 Reads

Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.

J Pharmacol Sci 2017 Feb 28;133(2):70-78. Epub 2017 Jan 28.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; iPS-non Clinical Experiments for Nervous System (iNCENS) Project, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka 565-0871, Japan. Electronic address:

Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machine learning-based in vitro system designed to detect seizure-inducing side effects. Read More

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http://dx.doi.org/10.1016/j.jphs.2017.01.003DOI Listing
February 2017
11 Reads

Long-term consequences of disrupting adenosine signaling during embryonic development.

Mol Aspects Med 2017 06 13;55:110-117. Epub 2017 Feb 13.

Child Health Research Institute, Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address:

There is growing evidence that disruption in the prenatal environment can have long-lasting effects on an individual's health in adulthood. Research on the fetal programming of adult diseases, including cardiovascular disease, focuses on epi-mutations, which alter the normal pattern of epigenetic factors such as DNA methylation, miRNA expression, or chromatin modification, rather than traditional genetic alteration. Thus, understanding how in utero chemical exposures alter epigenetics and lead to adult disease is of considerable public health concern. Read More

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http://dx.doi.org/10.1016/j.mam.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487283PMC
June 2017
12 Reads

Using pharmacokinetic modelling to improve prescribing practices of intravenous aminophylline in childhood asthma exacerbations.

Pulm Pharmacol Ther 2017 04 18;43:6-11. Epub 2017 Jan 18.

Alder Hey Children's Hospital, Liverpool, UK; Department of Women's and Children's Health, University of Liverpool, UK; NIHR Alder Hey Clinical Research Facility, Alder Hey Children's Hospital, Liverpool, UK. Electronic address:

Objective: To evaluate physiologically based pharmacokinetic modelling (PBPK) software in paediatric asthma patients using intravenous aminophylline.

Methods: Prospective clinical audit of children receiving iv aminophylline (July 2014 to June 2016), and in-silico modelling using Simcyp software.

Results: Thirty-eight admissions (25 children) were included. Read More

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http://dx.doi.org/10.1016/j.pupt.2017.01.007DOI Listing
April 2017
12 Reads

Dodecyl Amino Glucoside Enhances Transdermal and Topical Drug Delivery via Reversible Interaction with Skin Barrier Lipids.

Pharm Res 2017 03 9;34(3):640-653. Epub 2017 Jan 9.

Skin Barrier Research Group, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005, Hradec Králové, Czech Republic.

Purpose: Skin permeation/penetration enhancers are substances that enable drug delivery through or into the skin.

Methods: To search for new enhancers with high but reversible activity and acceptable toxicity, we synthesized a series of D-glucose derivatives, both hydrophilic and amphiphilic.

Results: Initial evaluation of the ability of these sugar derivatives to increase permeation and penetration of theophylline through/into human skin compared with a control (no enhancer) or sorbitan monolaurate (Span 20; positive control) revealed dodecyl 6-amino-6-deoxy-α-D-glucopyranoside 5 as a promising enhancer. Read More

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http://link.springer.com/10.1007/s11095-016-2093-z
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http://dx.doi.org/10.1007/s11095-016-2093-zDOI Listing
March 2017
21 Reads

Potential risks of maternal administration of Mucophylline on the pups of albino rats during lactation.

Exp Toxicol Pathol 2017 Mar 23;69(3):143-152. Epub 2016 Dec 23.

Zoology Department, Faculty of Science, Cairo University, Egypt.

The present study was undertaken to evaluate the potential risks of the mucolytic and broncholytic drug, Theophylline derivatives (Mucophylline) maternally administered on the pups. The nursing rats orally administered from 1st postpartum day (PPD) to 21th PPD with two different doses 30.83mg/kg (low dose) and 66. Read More

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http://dx.doi.org/10.1016/j.etp.2016.12.008DOI Listing
March 2017
17 Reads

An evaluation of the anti-inflammatory, antipyretic and analgesic effects of hydroethanol leaf extract of Albizia zygia in animal models.

Pharm Biol 2017 Dec;55(1):338-348

a Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana.

Context: The leaves of Albizia zygia (DC.) J.F. Read More

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http://dx.doi.org/10.1080/13880209.2016.1262434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130645PMC
December 2017
23 Reads
1 Citation
1.340 Impact Factor

Measurement of caffeine and its three primary metabolites in human plasma by HPLC-ESI-MS/MS and clinical application.

Biomed Chromatogr 2017 Jun 4;31(6). Epub 2017 Jan 4.

Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.

Caffeine is a mild stimulant with significant potential for abuse, being consumed in larger doses with the widespread availability of energy drinks and by novel routes of administration such as inspired powder, oral sprays and electronic cigarettes. How these recent changes in caffeine consumption affecting caffeine disposition and abuse potential is of growing concern. In the study of caffeine disposition in humans, it is common to only measure the caffeine concentration; however, caffeine's three major metabolites (paraxanthine, theobromine and theophylline) retain central nervous system stimulant activity that may contribute to the overall pharmacological activity and toxicity. Read More

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http://doi.wiley.com/10.1002/bmc.3900
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http://dx.doi.org/10.1002/bmc.3900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415443PMC
June 2017
16 Reads

Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain.

Physiol Behav 2017 01 6;168:11-19. Epub 2016 Oct 6.

Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de SantaMaria, Santa Maria, RS 97105-900, Brazil. Electronic address:

Hyperlipidemia is a risk factor for the development of cognitive dysfunction and atherosclerosis. Natural compounds have recently received special attention in relation to the treatment of disease due to their low cost and wide margin of safety. Thus, the aim of this study was to determine the possible preventive effect of guarana powder (Paullinia cupana) on memory impairment and acetylcholinesterase (AChE) activity in the brain structures of rats with Poloxamer-407-induced hyperlipidemia. Read More

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http://dx.doi.org/10.1016/j.physbeh.2016.10.003DOI Listing
January 2017
19 Reads

Human Umbilical Cord Blood-Derived Neural Stem Cell Line as a Screening Model for Toxicity.

Neurotox Res 2017 04 2;31(3):319-326. Epub 2016 Nov 2.

Central Research Laboratory, Institute of Medical Sciences and Sum Hospital, Siksha 'O' Anusandhan University, Kalinga Nagar, Bhubaneswar, Odisha, 751003, India.

The aim was to investigate whether a human neural stem cell (NSC) line derived from human umbilical cord blood (hUCB) can be used for toxicity study. Toxicity of both neurotoxic environmental xenobiotics, methyl mercury chloride (CHHgCl), lead acetate (CHCOOPb), and chlorpyrifos (CP), and non-neurotoxic insecticide, dichlorvos, as well as non-neurotoxic drugs, theophylline and acetaminophen were assessed. Additionally, differentiation of neuronal and glial cell lines derived from hUCB was elucidated. Read More

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http://link.springer.com/10.1007/s12640-016-9681-x
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http://dx.doi.org/10.1007/s12640-016-9681-xDOI Listing
April 2017
11 Reads

Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.

Molecules 2016 Jul 27;21(8). Epub 2016 Jul 27.

Health Sciences Research Centre (CICS-UBI), University of Beira Interior, 6201-506 Covilhã, Portugal.

Methylxanthines are a group of phytochemicals derived from the purine base xanthine and obtained from plant secondary metabolism. They are unobtrusively included in daily diet in common products as coffee, tea, energetic drinks, or chocolate. Caffeine is by far the most studied methylxanthine either in animal or epidemiologic studies. Read More

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http://www.mdpi.com/1420-3049/21/8/974
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http://dx.doi.org/10.3390/molecules21080974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273298PMC
July 2016
17 Reads

Bronchodilator and Anti-Inflammatory Action of Theophylline in a Model of Ovalbumin-Induced Allergic Inflammation.

Adv Exp Med Biol 2016 ;935:53-62

Department of Pharmacology and Biomed, Jessenius School of Medicine in Martin, Comenius University in Bratislava, 4C Mala Hora, 03601, Martin, Slovakia.

Phosphodiesterases (PDEs) represent a super-family of 11 enzymes hydrolyzing cyclic nucleotides into inactive 5' monophosphates. Inhibition of PDEs leads to a variety of cellular effects, including airway smooth muscle relaxation, inhibition of cellular inflammation, and immune responses. In this study we focused on theophylline, a known non-selective inhibitor of PDEs. Read More

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http://dx.doi.org/10.1007/5584_2016_31DOI Listing
December 2017
12 Reads

Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.

Brain Res Bull 2016 06 3;124:172-81. Epub 2016 May 3.

Department of Zoology, University of West Hungary Savaria Campus, Szombathely, Károlyi Gáspár tér 4., 9700, Hungary. Electronic address:

The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intraperitoneal (i.p. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2016.05.001DOI Listing
June 2016
24 Reads

The effects of intravenous aminophylline on level of consciousness in acute intentional benzodiazepines poisoning in comparison to flumazenil.

Hum Exp Toxicol 2017 Mar 11;36(3):311-316. Epub 2016 Jul 11.

2 Tehran University of Medical Sciences, Tehran, Iran.

Aim: Acute intentional benzodiazepine poisoning is marked by a significant loss of consciousness, aspiration pneumonia, and increased rates of mortality and morbidity, especially in older patients with underlying heart or lung disease. These patients may need flumazenil to reverse the respiratory effects of benzodiazepines. The positive effects of aminophylline on respiration and neonatal apnea improvement have been shown previously. Read More

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http://dx.doi.org/10.1177/0960327116646619DOI Listing
March 2017
8 Reads

Sampling time and indications appropriateness for therapeutically monitored drugs at a teaching university hospital in Oman.

Saudi Pharm J 2015 Sep 24;23(4):458-62. Epub 2014 Nov 24.

Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Oman.

Objective: To evaluate prospectively the appropriateness of indications, sampling time and outcome of TDM requests at a teaching university hospital in Oman.

Methods: A prospective cross-sectional study was conducted over a four months period; October 2013-January 2014 at the Sultan Qaboos University Hospital (SQUH), an 855 bed university teaching hospital. Appropriateness criteria for indications and sampling time were defined a priori. Read More

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http://dx.doi.org/10.1016/j.jsps.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834676PMC
September 2015
20 Reads

Different antibacterial activity of novel theophylline-based ionic liquids - Growth kinetic and cytotoxicity studies.

Ecotoxicol Environ Saf 2016 Aug 12;130:54-64. Epub 2016 Apr 12.

Faculty of Chemical Technology, Poznan University of Technology, M. Skłodowskiej-Curie 2, 60-965 Poznan, Poland.

The aim of this study was to investigate novel theophylline-based ionic liquids and their cytotoxic effects towards model Gram-positive and Gram-negative bacteria (Bacillus cereus and Escherichia coli, respectively). Growth kinetics, respiratory rates and dehydrogenase activities were studied in the presence of ionic liquids at concentrations ranging from 10 to 1000mg/L. Additionally, the influence of ionic liquids on bacterial cells associated with specific interactions based on the structure of cell wall was evaluated. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2016.04.004DOI Listing
August 2016
27 Reads

Fenethylline (Captagon) Abuse - Local Problems from an Old Drug Become Universal.

Basic Clin Pharmacol Toxicol 2016 Aug 8;119(2):133-40. Epub 2016 Apr 8.

Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Fenethylline is a theophylline derivative of amphetamine having stimulant effects similar to those of other amphetamine-type derivatives. Fenethylline was used as medicament for hyperactivity disorders in children, narcolepsy and depression, but it has also been used as a drug of abuse under the common name of 'captagon'. Unlike other drugs of abuse, the clandestine synthesis of fenethylline is simple, using inexpensive laboratory instrumentation and raw materials legal to obtain. Read More

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http://dx.doi.org/10.1111/bcpt.12584DOI Listing
August 2016
16 Reads