Mutat Res Genet Toxicol Environ Mutagen 2019 Feb 23;838:9-15. Epub 2018 Nov 23.
Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26, Tonomach, Kawasaki-ku, Kawasaki, 210-9501, Japan.
Previously, we proposed 12 marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2 and Tubb4b) to discriminate mouse genotoxic hepatocarcinogens (GTHC) from non-genotoxic hepatocarcinogens (NGTHC). This was determined by qPCR and principal component analysis (PCA), as the aim of an in vivo short-term screening for genotoxic hepatocarcinogens. For this paper, we conducted an application study of the 12 mouse marker genes to rat data, Open TG-GATEs (public data). Read More