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Front Vet Sci 2022 9;9:843031. Epub 2022 Jun 9.

Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.

This study evaluated the immunotoxic effects of thallium (Tl) in Nile tilapia fingerlings and the recovery role of dietary polysaccharides (ASs). An 8-week experiment was designed where 180 fishes were randomly and equally assigned in triplicates into the six groups: the control group (CNT) was reared in unpolluted water and fed a commercial diet, two groups were fed a well-balanced commercial diet plus 1.5 and 3. Read More

Environ Sci Pollut Res Int 2022 Jun 23. Epub 2022 Jun 23.

Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.

Thallium (Tl) is a trace metal enriched in wastewaters associated with mining and smelting of base metals. The toxicity of Tl to aquatic biota is poorly understood, particularly with respect to its sublethal effects. In this study, phototactic behavioural responses of naïve (i. Read More

BMC Med 2022 Jun 17;20(1):207. Epub 2022 Jun 17.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Osteoarthritis (OA) is a worldwide public health concern, mainly afflicting older adults. Although the etiology of OA remains unclear, environmental factors are increasingly considered as non-negligible risk factors. This study aims to evaluate the associations of urinary metals with OA risk and the mediated effect of biological aging. Read More

J Chromatogr B Analyt Technol Biomed Life Sci 2022 Jul 28;1204:123312. Epub 2022 May 28.

Graduate Program in Pure and Applied Chemistry (POSQUIPA) Federal University of Western Bahia, Rua Bertioga, 892, Morada Nobre II, Barreiras, Bahia, CEP 47810-059, Brazil; Department of Biochemistry, Laboratory of Immunopathology Keizo Asami-LIKA, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Graduate Program in Applied Health Biology (PPGBAS) Federal University of Pernambuco, Recife, Pernambuco, CEP: 50670-901, Brazil. Electronic address:

The Caenorhabditis elegans (C. elegans) is a model organism that has been increasingly used in health and environmental toxicity assessments. The quantification of such elements in vivo can assist in studies that seek to relate the exposure concentration to possible biological effects. Read More

Eur J Mass Spectrom (Chichester) 2022 Jun 3:14690667221105835. Epub 2022 Jun 3.

Department of Pharmaceutical Analysis, 78997GITAM Institute of Pharmacy, Gandhi Institute of Technology and Management (GITAM) (Deemed to be University), Visakhapatnam, 530 045, Andhra Pradesh, India.

Atorvastatin calcium is employed as front-line treatment for cardiovascular diseases. According to the international conference on harmonization (ICH) guideline ICH Q3D, elemental impurities can come into drug products from various sources. These elemental impurities do not have any therapeutic benefit to the end-user. Read More

Anal Lett 2022 8;55(8):1269-1280. Epub 2021 Dec 8.

Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States.

Thallium (Tl) can be released as a byproduct of smelting, mining, and other industries, causing human exposure. There are knowledge gaps on the toxicity of thallium compounds, so the National Toxicology Program is investigating the toxicity of thallium (I) sulfate in rodents. We developed and validated a method to quantitate Tl in rodent plasma and secondary matrices. Read More

Sci Total Environ 2022 Sep 12;838(Pt 2):155899. Epub 2022 May 12.

Centre for Mined Land Rehabilitation, Sustainable Minerals Institute, The University of Queensland, Australia. Electronic address:

Biscutella laevigata is the strongest known thallium (Tl) hyperaccumulator plant species. However, little is known about the ecophysiological processes leading to root uptake and translocation of Tl in this species, and the interactions between Tl and its chemical analogue potassium (K). Biscutella laevigata was subjected to hydroponics experimentation in which it was exposed to Tl and K, and it was investigated in a rhizobox experiment. Read More

Environ Res 2022 Sep 7;212(Pt C):113413. Epub 2022 May 7.

Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, 60612, USA; Chicago Center for Health and Environment (CACHET), University of Illinois at Chicago, 835 S. Wolcott, Chicago, IL, 60612, USA.

Background: Disrupted thyroid homeostasis plays a role in neurocognitive dysfunction and metabolic disorders. Since individuals are exposed to multiple metals simultaneously, it is important to assess the effects of metal mixtures on thyroid hormone status. This study aimed to investigate the associations of metal mixtures and individual metals with thyroid hormone levels. Read More

Environ Pollut 2022 Aug 6;306:119388. Epub 2022 May 6.

Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Metals may affect adversely cardiovascular system, but epidemiological evidence on the associations of priority-controlled metals including antimony (Sb), arsenic (As), cadmium, lead, and thallium with children's blood pressure (BP) was scarce and inconsistent. We conducted two panel studies with 3 surveys across 3 seasons among 144 and 142 children aged 4-12 years in Guangzhou and Weinan, respectively. During each seasonal survey, urine samples were collected for 4 consecutive days and BP was measured on the 4th day. Read More

Neurotox Res 2022 Jun 27;40(3):814-824. Epub 2022 Apr 27.

Laboratorio de Aminoácidos Excitadores/Laboratorio de Neurofarmacología Molecular y Nanotecnología, Instituto Nacional de Neurología y Neurocirugía, 14269, Mexico City, Mexico.

Thallium (Tl) is a heavy metal that causes toxicity in several organs, including the brain. Its cytotoxic profile, combined with its affinity for tumor cells when used as a radioligand for labeling these cells, suggests its potential use as antitumor therapy. In this study, glioblastoma cell lines C6 (from rat) and U373 (from human) were exposed to increased concentrations of thallium(I) acetate (5, 10, 50, 100, or 200 µM) and several toxic endpoints were evaluated, including loss of confluence and morphological changes, loss of cell viability, changes in cell cycle, and apoptosis. Read More

Environ Sci Technol 2022 May 18;56(9):5530-5541. Epub 2022 Apr 18.

Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, College of Environment and Ecology, Chongqing University, Chongqing 400044, China.

The redox transformation between the oxidation states of thallium (Tl(I) and Tl(III)) is the key to influencing its toxicity, reactivity, and mobility. Dissolved iron (Fe) is widely distributed in the environment and coexists at a high level with Tl in acidic mine drainages (AMDs). While ultraviolet (UV) light and HO can directly (by inducing Tl(III) reduction) and indirectly (by inducing Fe(III) to form reactive intermediates) impact the redox cycles of Tl in Fe(III)-containing solutions, the kinetics and mechanism remain largely unclear. Read More

Chemosphere 2022 Jun 24;297:134102. Epub 2022 Feb 24.

School of Medicine, Jinan University, Guangzhou, 510632, China. Electronic address:

Heavy metals play an important role in inducing fine particulate matter (PM) related cardiovascular disease (CVD). However, most of the past researches concerned the associations between CVD mortality and the PM mass, which may not reveal the CVD mortality risk contributed by heavy metals in PM. This study explored the correlations between individual heavy metals in PM and CVD mortality, identified the heavy metals that significantly contribute to PM-related CVD, heart disease (HD), and cerebrovascular disease (CEV) mortality, and attempted to establish corresponding source control measures. Read More

Environ Res 2022 07 22;210:112976. Epub 2022 Feb 22.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Exposure to metals may contribute to the development of metabolic syndrome (MetS); however, evidence from midlife women who are at greater risk of cardiometabolic disease is limited. We assessed the associations of 15 urinary metal concentrations with incident MetS in a prospective cohort of midlife women in the United States. The study population included 947 White, Black, Chinese and Japanese women, aged 45-56 years, free of MetS at baseline (1999-2000), who participated in the Study of Women's Health Across the Nation Multi-Pollutant Study. Read More

BMC Bioinformatics 2022 Feb 17;22(Suppl 5):620. Epub 2022 Feb 17.

Department of Food Science, National Taiwan Ocean University, Keelung City, 20224, Taiwan.

Background: Naturally existing and human-produced heavy metals are released into the environment and cannot be completely decomposed by microorganisms, but they continue to accumulate in water and sediments, causing organisms to be exposed to heavy metals.

Results: This study designs and proposes heavy metal hazard decision trees for aquatic products, which are divided into seven categories including pelagic fishes, inshore fishes, other fishes, crustaceans, shellfish, cephalopods, and algae. Based on these classifications, representative fresh and processed seafood products are at the root of the heavy metal hazard decision trees. Read More

Sci Total Environ 2022 May 29;821:153399. Epub 2022 Jan 29.

Department of Agronomy, Food, Natural resources, Animals and Environment (DAFNAE), University of Padova, Agripolis Campus, Viale dell'Università, 16, 35020 Legnaro, PD, Italy.

Thallium is a trace metal with severe toxicity. Contamination of thallium (Tl) generated by steel and non-ferrous metals industry is gaining growing concern worldwide. However, little is known on Tl contamination owing to industrial activities using carbonate minerals. Read More

Chemosphere 2022 Apr 7;293:133570. Epub 2022 Jan 7.

Department of Global Health, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China; Global Health Institute, Wuhan University, 115# Donghu Road, Wuhan, 430071, China. Electronic address:

Exposure to fine particulate matter (PM) has been reported to increase the risks of chronic kidney disease. However, limited research has assessed the effect of PM and its constituents on renal function, and the underlying mechanism has not been well characterized. We aimed to evaluate the association of PM and its constituents with kidney indicators and to explore the roles of systematic oxidative stress and inflammation in the association. Read More

Environ Res 2022 04 28;206:112615. Epub 2021 Dec 28.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

The association between prenatal exposure to the metal mixture and allergic diseases is poorly understood. We aimed to explore the individual effect and the combined effect of prenatal exposure to vanadium (V), chromium (Cr), nickel (Ni), arsenic (As), cadmium (Cd), thallium (Tl), and lead (Pb) on early childhood allergic diseases based on a birth cohort study that included 628 mother-infant pairs. Metals were measured in maternal urine samples collected in the first, second, and third trimesters. Read More

Sci Total Environ 2022 Mar 23;813:152650. Epub 2021 Dec 23.

Department of Chemistry, Covenant University, Km 10 Idiroko Road, Ota, Nigeria. Electronic address:

The pervasive existence of microplastics (MPs) and toxic metals is raising environmental and health concerns. Plastics are essentially a complex mixture of chemicals, but exposure to the aquatic environment increases their complexity through contaminant desorption/sorption. The aim of this study was to establish baseline data on the elemental occurrence and distribution of potentially toxic and geochemical metals/metalloids in microplastics 1-5 mm and mesoplastics (> 5 mm - 1 cm) along designated coastlines of the Gulf of Guinea (Nigeria) in addition to enabling more comprehensive ecotoxicological risk assessment. Read More

Sci Total Environ 2022 Mar 14;812:152370. Epub 2021 Dec 14.

Nanjing Institute of Environmental Sciences, Ministry of Environment and Ecology of China, Nanjing 210042, China. Electronic address:

With thousands of chemicals discharged into the aquatic environment, it is necessary to identify those that are likely to be having the greatest impact on wildlife to better protect the ecosystem. A risk ranking approach was developed to compare the ecotoxicological risk of chemicals on aquatic wildlife with a wide range of environmental measurement data and ecotoxicity data. Nineteen metals including some rarely monitored ones including antimony (Sb), molybdenum (Mo), cobalt (Co), vanadium (V), titanium (Ti) and thallium (Tl) in the lower Yangtze River were risk ranked as a case study. Read More

Environ Pollut 2022 Jan 18;293:118545. Epub 2021 Nov 18.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, China. Electronic address:

Thallium, a highly toxic heavy metal and priority pollutant, has been widely reported to cause neurodevelopmental toxicity in animals. However, accessible epidemiological studies concerning the neurodevelopmental toxicity of early-life thallium exposure in humans are limited. In a prospective birth cohort including 2164 mother-child pairs, we explored the effect of prenatal serum thallium exposure on cognitive development among preschool-aged children born in Ma'anshan, Anhui, China. Read More

Reprod Toxicol 2021 12 9;106:94-102. Epub 2021 Oct 9.

College of Health and Human Services, George Mason University, 4400 University Drive, MS 2G7, Fairfax, VA 22030, United States. Electronic address:

Multiple studies have demonstrated a global population-wide decline in semen quality, with sperm concentrations having fallen 50 % over the past 50 years. Several metal and metalloid ("metal(loid)") compounds are known to have testicular toxicity, raising concerns about their contribution to rising infertility. In the male reproductive tract, metal(loid)s can reduce semen quality and disturb function both directly, by inducing tissue damage, and indirectly, by disrupting hormone production and secretion. Read More

Biometals 2021 12 16;34(6):1295-1311. Epub 2021 Sep 16.

Laboratorio de Neuroprotección, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos Cuernavaca, Av. Universidad 1001 Col. Chamilpa, Cuernavaca, C.P. 62209, Morelos, Mexico.

Thallium (TI) is one of the most toxic heavy metals. Human exposure to Tl occurs through contaminated drinking water and from there to food, a threat to health. Recently, environmental contamination by Tl has been reported in several countries, urging the need for studies to determine the impact of endogenous and exogenous mechanisms preventing thallium toxicity. Read More

J Hazard Mater 2022 02 30;423(Pt A):127080. Epub 2021 Aug 30.

Key Laboratory of Water Quality and Conservation in the Pearl River Delta, Ministry of Education, Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, China; State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu, China.

Thallium (Tl) is a trace metal with high toxicity. Comprehensive investigation of spatial distribution of Tl and microorganism is still limited in soils from mining area. In this study, 16S rRNA sequencing and network analysis were used for deciphering the co-occurrence patterns of bacterial communities in two different types of soil profiles around a typical Tl-bearing pyrite mine. Read More

Fish Shellfish Immunol 2021 Nov 10;118:251-260. Epub 2021 Sep 10.

Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 22758, Egypt. Electronic address:

A 60-day experiment was performed to assess the efficacy of dietary Astragalus membranaceus polysaccharides (ASP) in attenuation of sub-lethal thallium (Tl) toxicity in Nile tilapia. Six experimental groups (in triplicates) were designed where a fish group was raised in clean water and fed basal diet and served as control (CONT), two groups were fed the basal diet supplemented with 0.15% and 0. Read More

J Trace Elem Med Biol 2021 Dec 25;68:126848. Epub 2021 Aug 25.

Graduate Program in Pure and Applied Chemistry, Federal University of Western Bahia, Rua Bertioga, 892, Morada Nobre II, CEP 47810-059, Barreiras, Bahia, Brazil; Immunopathology Laboratory Keizo Asami. The Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address:

Background: Thallium (Tl) is a toxic metalloid and an emerging pollutant due to electronic devices and dispersal nearby base-metal mining. Therefore, Tl poses a threat to human health and especially the long-term impact on younger individuals exposed is still unknown. This study aimed to evaluate the toxic effects of thallium acetate in C. Read More

Environ Int 2021 12 6;157:106808. Epub 2021 Aug 6.

Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Exposure to metals/metalloids from both the natural environment and anthropogenic sources have a complex influence on human health. However, relatively few studies have explored the relations of exposure to multiple metals/metalloids with mortality. Therefore, this prospective study aims to examine the relations of multiple metal/metalloids exposures with all-cause and cardiovascular disease (CVD) mortality. Read More

J Hazard Mater 2022 Feb 28;424(Pt C):126513. Epub 2021 Jun 28.

Department of Agricultural Chemistry, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan. Electronic address:

Paddy soils contaminated by thallium (Tl) have been frequently reported; however, their ecotoxicological impact in the paddy field is less known. We used a novel soil-fish exposure system with larvae of rice fish medaka (Oryzias latipes) to assess the bioavailability of Tl from soils to fish and causal toxicity under simulated conditions of rice cultivation. Two acidic soils [Pingzhen (Pc) and Sankengtzu (Sk)] spiked with monovalent Tl [Tl(I), 75-250 mg/kg] released higher Tl into pore or overlying waters than neutral soils [Sangkang (Su)], which resulted in higher mortality to exposed fish. Read More

EJNMMI Res 2021 Jul 5;11(1):63. Epub 2021 Jul 5.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Background: Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron capture, releasing around 37 Auger and Coster-Kronig electrons per decay. However, its therapeutic and toxic effects in cancer cells remain largely unexplored. Read More

J Inorg Biochem 2021 09 3;222:111469. Epub 2021 May 3.

Laboratory of Inorganic Chemistry and Advanced Materials, School of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

Among transition and non-transition metals, thallium is a unique case of an element which, despite its known toxicity, provides interesting challenges through its biology and chemistry linked to diagnosis of human pathophysiologies. Poised to investigate in-depth the structural and electronic aspects of thallium involvement in physiological processes, the synthetic exploration of aqueous binary systems of Tl(I) with physiological binders from the family of hydroxycarboxylic acids (glycolic, lactic, mandelic and citric acid) was pursued in a pH-specific fashion. The isolated crystalline coordination polymers, emerging from that effort, were physicochemically characterized through elemental analysis, FT-IR, ESI-MS, H-/C-NMR, and X-ray crystallography. Read More

J Pharmacol Toxicol Methods 2021 Jul-Aug;110:107087. Epub 2021 Jun 19.

University of Zagreb, Faculty of Pharmacy and Biochemistry, Kovaciceva 1, Zagreb, Croatia. Electronic address:

The aim of the study was to develop fast and accurate method for assessment of intracellular level of cadmium (Cd) and thallium (Tl), and to establish accumulation of the metals in the cells. HepG2 cells were treated with Cd or Tl (1.0 or 10. Read More