30,799 results match your criteria Toxicity Terpene


A Review of Terpenes from Marine-Derived Fungi: 2015-2019.

Mar Drugs 2020 Jun 18;18(6). Epub 2020 Jun 18.

School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Marine-derived fungi are a significant source of pharmacologically active metabolites with interesting structural properties, especially terpenoids with biological and chemical diversity. In the past five years, there has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered. In this updated review, we examine the chemical structures and bioactive properties of new terpenes from marine-derived fungi, and the biodiversity of these fungi from 2015 to 2019. Read More

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http://dx.doi.org/10.3390/md18060321DOI Listing

Terpenoids as Potential Geroprotectors.

Antioxidants (Basel) 2020 Jun 17;9(6). Epub 2020 Jun 17.

Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya st., 167982 Syktyvkar, Russia.

Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). Read More

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http://dx.doi.org/10.3390/antiox9060529DOI Listing

Polak: Root Extract Has High Antioxidant Activity and Low Cytotoxicity .

J Med Food 2020 Jun 16. Epub 2020 Jun 16.

Physico-Chemical Studies and Natural Products Laboratory (LEFQPN), Federal University of Pampa (UNIPAMPA), Uruguaiana, Brazil.

The Asteraceae family is widely known for its therapeutic, aromatic, and nutritional properties. (), a member of the family, is widely used in folk medicine in southern Brazil. In this study, we aim to assess compounds present in root extracts of , and evaluate their antioxidant capacity and toxicity. Read More

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http://dx.doi.org/10.1089/jmf.2019.0309DOI Listing

Efficacy of geraniol and ß-citronellol against freshwater and marine monogeneans.

J Aquat Anim Health 2020 Jun 7. Epub 2020 Jun 7.

Centro de Investigación en Alimentación y Desarrollo, A.C. Unidad Mazatlán en Acuicultura y Manejo Ambiental, Av. Sábalo-Cerrito s/n, Mazatlán, 82112, Sinaloa, Mexico.

Monogeneans are parasitic flatworms that may be a threat for finfish aquaculture. In this study, the anthelminthic activity of two terpenes, geraniol and β-citronellol, was tested in vitro against ancyrocephalin and diplectanid monogeneans. Experiments were performed in both water and a culture medium. Read More

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http://dx.doi.org/10.1002/aah.10109DOI Listing

Evaluation of the Toxicity of C. A. Mey Essential Oil to Storage and Greenhouse Insect Pests and a Predator Ladybird.

Foods 2020 Jun 2;9(6). Epub 2020 Jun 2.

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.

The use of chemical insecticides has had several side-effects, such as environmental contamination, foodborne residues, and human health threats. The utilization of plant-derived essential oils as efficient bio-rational agents has been acknowledged in pest management strategies. In the present study, the fumigant toxicity of essential oil isolated from was assessed against cosmopolitan stored-product insect pests: Everts (khapra beetle), (Fabricius) (lesser grain borer), (Herbst) (red flour beetle), and (L. Read More

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http://dx.doi.org/10.3390/foods9060712DOI Listing

[Effects of ginsenoside Rg5 on cell cycle and invasion of gastric cancer].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Jan;36(1):51-54

Department of General Tumor Surgery, Xinxiang Central Hospital, Xinxiang 453000.

Objective: To investigate the effects of ginsenoside Rg5 on the proliferation, cycle and invasion of gastric carcinoma cell lines, providing experimental evidence for the anti-tumor mechanism of ginsenoside Rg5.

Methods: In this experimental study, the human immortalized normal gastric mucosa cell GES-1 and gastric adenocarcinoma cell lines AGS and MKN-45 were treated with Rg3 and Rg5 at the concentrations of 10, 20, 30, 40 and 50 μmol/L for 24 h, 3 parallel holes were set for each group. A cell viability test, cell cycle analysis, transwell assay, ELISA and immunoblotting were performed. Read More

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http://dx.doi.org/10.12047/j.cjap.5891.2020.011DOI Listing
January 2020

Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19.

Int J Mol Sci 2020 May 27;21(11). Epub 2020 May 27.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.

At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus disease-19 (COVID-19)), which frequently leads to lethal pulmonary inflammatory responses. COVID-19 pathology is characterized by extreme inflammation and amplified immune response with activation of a cytokine storm. A subsequent progression to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can take place, which is often followed by death. Read More

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http://dx.doi.org/10.3390/ijms21113812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312074PMC

Outcomes of concurrent radiotherapy with weekly docetaxel and platinum-based chemotherapy in stage III non-small-cell lung cancer.

Cancer Radiother 2020 Jul 18;24(4):279-287. Epub 2020 May 18.

Department of radiation oncology, Cancer Center GF Leclerc, Dijon, France.

Purpose: The present study evaluated the outcomes of concurrent weekly docetaxel and platinum-based drug doublet in association with concurrent thoracic radiotherapy (TR) in the curative treatment of stage III locally advanced non-small-cell lung cancer (NSCLC).

Patients And Methods: Patients with stage IIIA/B NSCLC were retrospectively included. Patients received weekly docetaxel and either cisplatin or carboplatin intravenous injections during concurrent TR (60 to 66Gy). Read More

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http://dx.doi.org/10.1016/j.canrad.2019.09.009DOI Listing

Celecoxib reduces Deoxynivalenol induced proliferation, inflammation and protein kinase C translocation via modulating downstream targets in mouse skin.

Chem Biol Interact 2020 Aug 13;326:109128. Epub 2020 May 13.

Genotoxicity Laboratory, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address:

Exposure to mycotoxins is mostly by ingestion but also occurs by the dermal and inhalation routes. The present study for the first time demonstrated that mycotoxin Deoxynivalenol (DON), permeates through Swiss albino mice skin, which demands awareness of health risks in people who are dermally exposed to mycotoxins especially agricultural farmers. Despite the widespread contamination of DON in food commodities studies to alleviate DON's toxicity are sparsely reported. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109128DOI Listing
August 2020
2.577 Impact Factor

Single- and repeated-dose toxicity studies on the novel HIV maturation inhibitor QF-036 in Sprague-Dawley rats.

Toxicol Lett 2020 Sep 4;329:26-30. Epub 2020 May 4.

State Key Laboratory of Innovative Natural Medicine and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Ganzhou, Jiangxi, China; Shanghai Qingrun Pharmaceutical Technology Co., Ltd., Shanghai, China. Electronic address:

QF-036 is a novel human immunodeficiency virus (HIV) maturation inhibitor that is a lupine triterpenoid derivative. The objective of this study was to evaluate the safety of QF-036. A single oral toxicity and a 4-week repeated oral toxicity were investigated in Sprague-Dawley (SD) rats. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.04.015DOI Listing
September 2020

How Dietary Diversity Enhances Hedonic and Eudaimonic Well-Being in Grazing Ruminants.

Front Vet Sci 2020 15;7:191. Epub 2020 Apr 15.

Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln, New Zealand.

Ruminants evolved in diverse landscapes of which they utilized, by choice, a diverse arrangement of plants (grasses, forbs, and trees) for food. These plants provide them with both primary (carbohydrates, protein, etc.) and secondary (phenolics, terpenes, etc. Read More

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http://dx.doi.org/10.3389/fvets.2020.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179672PMC

Efficacy and Safety of Weekly Paclitaxel in Breast Cancer With Symptomatic Bone Marrow Infiltration.

Anticancer Res 2020 May;40(5):2955-2960

Breast Cancer Unit, Centre François Baclesse, Institut Normand du Sein, Caen, France.

Background/aim: Currently, there is no recommendation for the treatment of breast cancer (BC) with bone-marrow cell infiltration (BMI). We evaluated the efficacy and safety of weekly-paclitaxel in this population.

Patients And Methods: This retrospective study included all BC patients with BMI receiving weekly-paclitaxel between January 2014 and May 2018. Read More

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http://dx.doi.org/10.21873/anticanres.14274DOI Listing
May 2020
1.872 Impact Factor

Study of the effect of cypermethrin on the spider Polybetes phytagoricus in different energy states.

Authors:
A Laino C F Garcia

Pestic Biochem Physiol 2020 May 5;165:104559. Epub 2020 Mar 5.

Instituto de Investigaciones Bioquímicas de La Plata "Profesor Doctor Rodolfo R. Brenner", 60 y 120 s/n, La Plata, Buenos Aires, Argentina. Electronic address:

Spiders are found among the most important predators of plague insects of numerous agricultural systems. They are the most numerous representatives of the Class Arachnid and are widely distributed in numerous ecosystems. Due to multiple variables, living beings are exposed to quantitative transitions of their energetic reserves, which affect their sensitivity before the different xenobiotics. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104559DOI Listing

The protective effect of Hibiscus sabdariffa calyxes extract against cypermethrin induced oxidative stress in mice.

Pestic Biochem Physiol 2020 May 30;165:104463. Epub 2019 Oct 30.

University of Carthage, Environmental Biomonitoring Laboratory (LBE), Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.

Cypermethrin (Cyp) is a kind of pyrethroids compound that is broadly used against different species of insects and pests. Cyp can also elicit a range of neurotoxic, immunotoxic, genotoxic and reproductive toxic effects on various experimental organisms. The aim of this study was to evaluate the protective effects of Hibiscus sabdariffa against the toxicity damage induced by Cyp exposure. Read More

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http://dx.doi.org/10.1016/j.pestbp.2019.09.007DOI Listing
May 2020
2.014 Impact Factor

Cypermethrin-induced cortical neurons apoptosis via the Nrf2/ARE signaling pathway.

Pestic Biochem Physiol 2020 May 19;165:104547. Epub 2020 Feb 19.

School of Public Health, Bengbu Medical College, Bengbu, Anhui 233030, China.

Pesticide residue is a common problem worldwide. Cypermethrin is a type II pyrethroid pesticide that has been widely used in recent years. It has become a widespread residual pesticide in the environment and agricultural products. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.02.013DOI Listing

NFE2L2 activator RS9 protects against corneal epithelial cell damage in dry eye models.

PLoS One 2020 22;15(4):e0229421. Epub 2020 Apr 22.

Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan.

Oxidative stress may cause ocular surface damage during the development of dry eye. Mammalian cells have defense systems against oxidative stress. A central regulator of the stress response is nuclear factor-erythroid 2-related factor 2 (NFE2L2). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229421PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176120PMC

Neuroprotective effect of 25-Methoxyhispidol A against CCl-induced behavioral alterations by targeting VEGF/BDNF and caspase-3 in mice.

Life Sci 2020 Jul 18;253:117684. Epub 2020 Apr 18.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

Brain oxidative stress and neuroinflammation have been implicated in various psychiatric disorders. The current study investigated the effect and mechanism of 25-Methoxyhispidol A (25-MHA) against CCl-induced anxiety and depression. Mice were challenged with CCl (1 ml/kg; i. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117684DOI Listing
July 2020
2.702 Impact Factor

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation.

Life Sci 2020 Jul 13;252:117669. Epub 2020 Apr 13.

Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. Electronic address:

Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effects of Rg1 in CSDS mice and explore its molecular mechanism. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117669DOI Listing
July 2020
2.702 Impact Factor

Abdominal contact of fluvalinate induces olfactory deficit in Apis mellifera.

Pestic Biochem Physiol 2020 Mar 1;164:221-227. Epub 2020 Mar 1.

Department of Life Sciences & Convergence Research Center for Insect Vectors, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea. Electronic address:

τ-Fluvalinate (fluvalinate) is a highly selective pyrethroid insecticide compound used for controlling ectoparasitic mites that cause major damages in honey bee colonies. Although honey bees have resistance and low toxicity to this xenobiotic chemical, little is known about the effects of this chemical on sensory modulation and behaviors in honey bees. Here we addressed the effect on olfactory cognition at the behavioral, molecular, and neurophysiological levels. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.02.005DOI Listing

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics.

Int J Mol Sci 2020 Apr 8;21(7). Epub 2020 Apr 8.

Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.

Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the genus, possesses good anti-inflammatory activity. Read More

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http://dx.doi.org/10.3390/ijms21072577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177626PMC

Engineering Cell Wall Integrity Enables Enhanced Squalene Production in Yeast.

J Agric Food Chem 2020 Apr 17;68(17):4922-4929. Epub 2020 Apr 17.

Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), 406-30, Jongga-ro, Jung-gu, Ulsan 44429, Republic of Korea.

Microbial production of many lipophilic compounds is often limited by product toxicity to host cells. Engineering cell walls can help mitigate the damage caused by lipophilic compounds by increasing tolerance to those compounds. To determine if the cell wall engineering would be effective in enhancing lipophilic compound production, we used a previously constructed squalene-overproducing yeast strain (SQ) that produces over 600 mg/L of squalene, a model membrane-damaging lipophilic compound. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c00967DOI Listing

Research Progress on the Molecular Mechanisms of Toxicology of Ethanol-Aconitine Induced Arrhythmia.

Fa Yi Xue Za Zhi 2020 Feb;36(1):115-119

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Abstract: Aconitum is one of the most widely used Chinese herbal medicines, and aconitine is the major toxic component in it. Aconitine can induce a variety of arrhythmias, resulting in death. Acute ethanol consumption causes arrhythmia as well. Read More

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http://dx.doi.org/10.12116/j.issn.1004-5619.2020.01.022DOI Listing
February 2020

Genotoxicity and sperm defects induced by 5-FU in male mice and the possible protective role of Pentas lanceolata-iridoids.

Mutat Res 2020 Feb - Mar;850-851:503145. Epub 2020 Jan 23.

Natural Compounds Chemistry Department, National Research Centre (NRC), Dokki, Cairo, Egypt.

5-Fluorouracil (5-FU) is a widely used antineoplastic drug. In this work, a comprehensive study was performed to detect the extent of chromosomal damage and morphological sperm defects induced by 5-FU in male mice and the possible protective role of the iridoids-rich fraction of Pentas lanceolata leaves (IFPL). Six main groups were examined in micronucleus and chromosomal assays: I- control negative, II- control positive (i. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2020.503145DOI Listing

Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway.

Life Sci 2020 Jul 1;252:117612. Epub 2020 Apr 1.

Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Aims: Intestinal mucositis is the most common side effect of 5-fluorouracil (5-Fu) treatment in cancer patients. Previous research suggested that andrographolide (Andro) attenuated the intestinal injury in colitis or diarrhea in mice. The present study was aimed at investigating the protective effect of Andro against 5-Fu induced intestinal mucositis and the underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117612DOI Listing

Hydrogen peroxide as a signalling molecule in plants and its crosstalk with other plant growth regulators under heavy metal stress.

Chemosphere 2020 Aug 14;252:126486. Epub 2020 Mar 14.

Department of Plant Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research, Corrensstraße 3, D-06466, Gatersleben, Germany.

Hydrogen peroxide (HO) acts as a significant regulatory component interrelated with signal transduction in plants. The positive role of HO in plants subjected to myriad of abiotic factors has led us to comprehend that it is not only a free radical, generated as a product of oxidative stress, but also helpful in the maintenance of cellular homeostasis in crop plants. Studies over the last two centuries has indicated that HO is a key molecule which regulate photosynthesis, stomatal movement, pollen growth, fruit and flower development and leaf senescence. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126486DOI Listing

Notch1-mediated histone demethylation of HCN4 contributes to aconitine-induced ventricular myocardial dysrhythmia.

Toxicol Lett 2020 Jul 28;327:19-31. Epub 2020 Mar 28.

Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, PR China; Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, PR China. Electronic address:

Traditional Chinese Medicines (TCMs)-containing aconitine are popular and indispensable home remedies in Asia for thousands of years due to its excellent pharmaceutical effects. Accumulating evidence has identified that repeated-dose of aconitine could cause polymorphic ventricular arrhythmias. However, underlying molecular mechanisms are still not fully understood. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.03.017DOI Listing

Essential Oils Extracted from Different Species of the Lamiaceae Plant Family as Prospective Bioagents against Several Detrimental Pests.

Molecules 2020 Mar 28;25(7). Epub 2020 Mar 28.

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo 38-90123, Italy.

On the basis of the side effects of detrimental synthetic chemicals, introducing healthy, available, and effective bioagents for pest management is critical. Due to this circumstance, several studies have been conducted that evaluate the pesticidal potency of plant-derived essential oils. This review presents the pesticidal efficiency of essential oils isolated from different genera of the Lamiaceae family including Gronovius, Jacquin, L. Read More

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http://dx.doi.org/10.3390/molecules25071556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180760PMC

Two-way immune effects of deoxynivalenol in weaned piglets and porcine alveolar macrophages: Due mainly to its exposure dosage.

Chemosphere 2020 Jun 10;249:126464. Epub 2020 Mar 10.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China. Electronic address:

Mycotoxins are toxic metabolites produced by fungal species that occur frequently in cereals and animal forages throughout the world, posing a serious threat to humans and animals. Although some studies showed the immunotoxicity of mycotoxins, little research focused on the two-way effects of mycotoxins on immune response in vitro and vivo. Here, we explored the effects of deoxynivalenol (DON), one of the most widely distributed mycotoxins, on immune function of piglets and porcine alveolar macrophages (PAMs), and found it exhibited bidirectional immune effects due to different exposure doses. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126464DOI Listing

Plant Bioactive Compounds in Pre- and Postharvest Management for Aflatoxins Reduction.

Front Microbiol 2020 12;11:243. Epub 2020 Mar 12.

Institute of Sciences of Food Production, Italian National Research Council, Bari, Italy.

Aflatoxins (AFs) are secondary metabolites produced by spp., known for their hepatotoxic, carcinogenic, and mutagenic activity in humans and animals. AF contamination of staple food commodities is a global concern due to their toxicity and the economic losses they cause. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080658PMC

Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use.

Pediatrics 2020 04;145(4)

Divisions of Pulmonary Medicine.

Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia. Although the exact etiology of idiopathic acute eosinophilic pneumonia remains unknown, an acute hypersensitivity reaction to an inhaled antigen is suggested, which is further supported by recent public health risks of vaping (electronic cigarette) use and the development of lung disease. Read More

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http://dx.doi.org/10.1542/peds.2019-3007DOI Listing

Toxicopathological studies on the effects of T-2 mycotoxin and their interaction in juvenile goats.

PLoS One 2020 26;15(3):e0229463. Epub 2020 Mar 26.

Division of Molecular Biology, Department of Water & Health Sciences-Faculty of Life Sciences, JSS Academy of Higher Education and Research (Deemed to be University), Mysuru, India.

Food and feeds contaminated with mycotoxins have been a threat to the rearing industry by causing some of the most fatal toxic reactions not only in the farm animals but also in humans who consume them. Toxicity to juvenile goats was induced by feed contamination with T-2 toxin (at 10 and 20 ppm dosage; group I and II, respectively). The toxicity impact was assessed on days 15 and 30 post treatment with respect to growth performance, oxidative stress, apoptotic studies and detailed pathomorphology. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229463PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098593PMC
June 2020
3.234 Impact Factor

Response Rate of Cisplatin Plus Docetaxel as Primary Treatment in Locally Advanced Head and Neck Carcinoma (Squamous Cell Types).

Asian Pac J Cancer Prev 2020 Mar 1;21(3):825-830. Epub 2020 Mar 1.

Department of Medical Oncology, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Objective: To evaluate the response rate of Cisplatin plus Docetaxel in the treatment of locally advanced head and neck squamous cell carcinomas (HNSCC) at a tertiary care hospital in Karachi, Pakistan.

Materials And Methods: It was a longitudinal study, conducted at the Department of Medical Oncology, Jinnah Postgraduate Medical Center, Karachi, Pakistan from December 2018 to June 2019. One hundred patients of age 14-66 years of age of either gender with histologically proven Squamous Cell Carcinoma of Head and Neck, Stage III and IV (locally advanced) with no distant metastases were included in the study. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.825DOI Listing

Vernonia anthelmintica (L.) Willd.: An ethnomedicinal, phytochemical, pharmacological and toxicological review.

J Ethnopharmacol 2020 Jun 20;256:112777. Epub 2020 Mar 20.

Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, Himachal Pradesh, India. Electronic address:

Ethnopharmacological Relevance: Vernonia anthelmintica (L.) Willd. (Asteraceae; Purple Fleabane) has a long history of traditional use for the management of several disorders related to skin, central nervous system, kidney, gynecology, gastrointestinal, metabolism, and general health. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112777DOI Listing
June 2020
2.998 Impact Factor

Transcription activation of β-carotene biosynthetic genes at the initial stage of stresses as an indicator of the increased β-carotene accumulation in isolated Dunaliella salina strain GY-H13.

Aquat Toxicol 2020 May 12;222:105472. Epub 2020 Mar 12.

Institute of Marine Biology & Pharmacology, Ocean College, Zhejiang University, 1 Zheda Road, Dinghai District, Zhoushan, 316000, Zhejiang, PR China; College of Marine Ocean Science and Technology, Zhejiang Ocean University, Zhoushan, 316022, PR China. Electronic address:

β-carotene is an efficient antioxidant and its accumulation is an oxidative response to stressors. Dunaliella salina strain GY-H13 is rich in β-carotene under environmental stresses, which was selected as material to understand the molecular mechanism underlying β-carotene biosynthesis. Seven full length cDNA sequences in β-carotene biosynthesis pathway were cloned, including geranylgeranyl pyrophosphate synthase (GGPS), phytoene synthase (PSY), phytoene desaturase (PDS), 15-cis-zeta-carotene isomerase (ZISO), zeta-carotene desaturase (ZDS), prolycopene isomerase (CRTISO), lycopene beta-cyclase (LCYb). Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105472DOI Listing

Cannabinol in the spotlight: Toxicometabolomic study and behavioral analysis of zebrafish embryos exposed to the unknown cannabinoid.

Chemosphere 2020 Aug 12;252:126417. Epub 2020 Mar 12.

Laboratory of Zoology, Biological Applications and Technology Department, University of Ioannina, 45110, Greece. Electronic address:

Cannabinol (CBN) is a degradation product of the cannabis metabolite Δ9-tetrahydrocannabinol. The CBN concentration in cannabis leaves ranges between 0.1 and 1. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126417DOI Listing

Nano selenium ameliorates oxidative stress and inflammatory response associated with cypermethrin-induced neurotoxicity in rats.

Ecotoxicol Environ Saf 2020 Jun 1;195:110479. Epub 2020 Apr 1.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Cypermethrin (CYP), a class II synthetic pyrethroid, is used to control household insects. CYP can cross the blood-brain barrier to exert neurotoxicity through changes in sodium ion channels. Selenium is an essential component of glutathione peroxidise enzyme; in addition, it shows a potential anti-inflammatory property. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110479DOI Listing

Fitness costs in chlorfenapyr-resistant populations of the chive maggot, Bradysia odoriphaga.

Ecotoxicology 2020 May 20;29(4):407-416. Epub 2020 Mar 20.

Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.

The chive maggot, Bradysia odoriphaga (Yang and Zhang) is an economically important insect pest, affecting many key vegetables, including Chinese chive, especially in northern China. Chlorfenapyr, a halogenated pyrrole insecticide that interferes with mitochondrial oxidative phosphorylation is widely used against B. odoriphaga. Read More

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http://dx.doi.org/10.1007/s10646-020-02183-7DOI Listing

Rhizobium response to sole and combined exposure to cadmium and the phytocompounds alpha-pinene and quercetin.

Ecotoxicology 2020 May 18;29(4):444-458. Epub 2020 Mar 18.

Department of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.

Soils can be contaminated with substances arising from anthropogenic sources, but also with natural bioactive compounds produced by plants, such as terpenes and flavonoids. While terpenes and flavonoids have received much less attention from research studies than metals, the effects that phytocompounds can have on soil organisms such as beneficial microorganisms should not be neglected. Herein we report the sole and combined exposure of Rhizobium to cadmium, to the monoterpene alpha-pinene and to the flavanol quercetin. Read More

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http://dx.doi.org/10.1007/s10646-020-02184-6DOI Listing

[Study on insecticide resistance of in southwest region of Shandong Province].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Jul;32(1):69-72

Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Jining 272033, China.

Objective: To explore the sensitivity of to common chemical insecticides in the southwestern region of Shandong Province, so as to provide a theoretical basis for the development of reasonable and effective mosquito control measures.

Methods: The resistance of larvae to 5 chemical insecticides, such as cypermethrin, deltamethrin, DDVP, propoxur, and acetofenate were tested by using the WHO biological test method in 2018, and the co-toxicity coefficients after compounding the above-mentioned insecticides were tested by using a drug compounding method.

Results: The resistance indexes of to cypermethrin, deltamethrin, DDVP, propoxur, and acetofenate in 3 cities were 144. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018261DOI Listing

Effects of glyphosate, cypermethrin, and chlorpyrifos on hematological parameters of the tegu lizard (Salvator merianae) in different embryo stages.

Chemosphere 2020 Aug 7;252:126433. Epub 2020 Mar 7.

Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina. Electronic address:

Different studies have demonstrated effects of pesticides during embryo development in vertebrates and stage-dependent effects, but there is no information concerning this for Salvator merianae. We evaluated the effects of the herbicides Glyphosate Roundup (GLY-RU) and Glyphosate Panzer Gold (GLY-PZ); and the insecticides Chlorpyrifos (CPF) and Cypermethrin (CYP), and their complex mixtures, at different concentrations in hematological parameters of S. merianae embryos at two different development stages. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126433DOI Listing

Loss of pyrethroid resistance in newly established laboratory colonies of Aedes aegypti.

PLoS Negl Trop Dis 2020 03 16;14(3):e0007753. Epub 2020 Mar 16.

Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Department of Microbiology, Immunology and Pathology, Arthropod Borne and Infectious Diseases Laboratory, Campus Delivery, Fort Collins, Colorado, United States of America.

Background: Resistance to pyrethroid insecticides in Aedes aegypti has become widespread after almost two decades of the frequent use of these pesticides to reduce arbovirus transmission. Despite this resistance, pyrethroids continue to be used because they are relatively inexpensive and have low human toxicity. Resistance management has been proposed as a way to retain the use of pyrethroids in natural populations. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117762PMC

Amenorrhea, fertility preservation, and counseling among young women treated with anthracyclines and taxanes for early-stage breast cancer, a retrospective study.

Medicine (Baltimore) 2020 Mar;99(11):e19566

Department of Medicine, King Hussein Cancer Center.

Chemotherapy may cause ovarian toxicity and infertility. Cancer patients are usually overwhelmed, and focus exclusively on cancer diagnosis and may not pay attention to fertility-related issues. In this paper we look at the rate of amenorrhea and fertility counseling among such young patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000019566DOI Listing

A novel insight into the potential toxicity mechanisms of Zhi-Zi-Hou-Po decoction by dynamic urinary metabolomics based on UHPLC-Q-Exactive Orbitrap-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Apr 3;1142:122019. Epub 2020 Feb 3.

Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

In recent years, depression occurs frequently. Given the long duration of the disease and the high risk of recurrence, the treatment of depression requires long-term medication. Zhi-Zi-Hou-Po Decoction (ZZHPD) has been used in clinical treatment of depression and related diseases for many years, and the potential toxic damage caused by its long-term use has gradually emerged. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122019DOI Listing

Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity.

Int J Nanomedicine 2020 24;15:553-571. Epub 2020 Jan 24.

Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, ChangChun, People's Republic of China.

Background: Breast cancer is the leading cause of cancer death in women. Chemotherapy to inhibit the proliferation of cancer cells is considered to be the most important therapeutic strategy. The development of long-circulating PEG and targeting liposomes is a major advance in drug delivery. Read More

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http://dx.doi.org/10.2147/IJN.S228715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986409PMC

Hydrogen sulfide upregulates miR-16-5p targeting PiK3R1 and RAF1 to inhibit neutrophil extracellular trap formation in chickens.

Ecotoxicol Environ Saf 2020 May 7;194:110412. Epub 2020 Mar 7.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.

Hydrogen sulfide (HS) is a toxic air pollutant that causes immune damage. Recent studies have found that neutrophil extracellular trap (NET) formation is one way in which neutrophils exert immune functions. In addition, the formation of NETs is also related to thrombosis and autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110412DOI Listing

Mechanism of deoxynivalenol-induced neurotoxicity in weaned piglets is linked to lipid peroxidation, dampened neurotransmitter levels, and interference with calcium signaling.

Ecotoxicol Environ Saf 2020 May 5;194:110382. Epub 2020 Mar 5.

College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China. Electronic address:

Deoxynivalenol(DON) has broad toxicity in livestock, but we know little about its neurotoxic mechanisms. We investigated DON neurotoxicity in the cerebral cortex, cerebellum, and hippocampus of "Duroc × Landrace × Yokshire" piglets. Control piglets were fed a basal diet, while those in low- and high-treatment groups were fed diets with 1. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110382DOI Listing

Acute lethal and sublethal effects of four insecticides on the lacewing (Chrysoperla sinica Tjeder).

Chemosphere 2020 Jul 25;250:126321. Epub 2020 Feb 25.

Key Laboratory of Pesticide Toxicology and Application Technique, College of Plant Protection, Shandong Agricultural University, Tai'an, China. Electronic address:

The lacewing, Chrysoperla sinica, is an important predatory insect, which plays an important role in the integrated pest management of agroforestry pests. However, the extensive use of insecticides negatively affects C. sinica. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126321DOI Listing

Toxic effects of terpinolene on Microcystis aeruginosa: Physiological, metabolism, gene transcription, and growth effects.

Sci Total Environ 2020 Jun 17;719:137376. Epub 2020 Feb 17.

Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, PR China.

Bioherbicide terpinolene is widely employed in the agricultural field because of its unique phytotoxic properties. However, little is known about the toxicity of bioherbicide on harmful algal blooms (HABs) and its mechanisms. Therefore, in this study, the inhibiting effect of bioherbicide terpinolene on the growth and physiological change of Microcystis aeruginosa was determined. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.137376DOI Listing

Triterpenoid corosolic acid modulates global CpG methylation and transcriptome of tumor promotor TPA induced mouse epidermal JB6 P+ cells.

Chem Biol Interact 2020 Apr 3;321:109025. Epub 2020 Mar 3.

Center for Phytochemical Epigenome Studies, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. Electronic address:

Epigenetic regulation is one of the driving forces in the process of carcinogenesis. Corosolic acid (CA); triterpenoid abundantly found in Lagerstroemia speciosa L. is known to modulate various cellular process including cellular oxidative stress and signaling kinases in various diseases, including skin cancer. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238714PMC

E-cigarette, or Vaping, Product Use-Associated Lung Injury Among Clusters of Patients Reporting Shared Product Use - Wisconsin, 2019.

MMWR Morb Mortal Wkly Rep 2020 Mar 6;69(9):236-240. Epub 2020 Mar 6.

On July 10, 2019, Wisconsin Department of Health Services (WDHS) was notified of five previously healthy adolescents with severe lung injuries who reported use of e-cigarette, or vaping, products before symptom onset. As of December 31, 2019, 105 confirmed or probable cases of e-cigarette, or vaping, product use-associated lung injury (EVALI)* had been reported to WDHS . Three social clusters (A, B, and C), comprising eight EVALI patients (cluster A = two patients, cluster B = three, and cluster C = three) were identified. Read More

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http://dx.doi.org/10.15585/mmwr.mm6909a4DOI Listing