34,542 results match your criteria Toxicity Terpene

The Significance of the Ocular Adverse Effect Induced by Systemic Taxane Application.

Front Biosci (Landmark Ed) 2022 May;27(6):171

Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi, China.

In recent years, in-depth research on anti-tumor therapy has brought the emergence of new active chemotherapeutic agents and combination regimens. However, as one of them, taxane drugs are widely used in clinical practice, but it should be noted that many side reactions caused by their application bring some difficulties to routine management. Among the side reactions related to taxane anti-tumor therapy, ocular adverse reactions are occasionally reported and are not life-threatening but may seriously affect patients' life quality. Read More

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RNA-Seq and 16S rRNA Analysis Revealed the Effect of Deltamethrin on Channel Catfish in the Early Stage of Acute Exposure.

Front Immunol 2022 3;13:916100. Epub 2022 Jun 3.

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.

Deltamethrin (Del) is a widely used pyrethroid insecticide and a dangerous material that has brought serious problems to the healthy breeding of aquatic animals. However, the toxicological mechanisms of Del on channel catfish remain unclear. In the present study, we exposed channel catfish to 0, 0. Read More

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Oleanolic Acid Derivative AXX-18 Exerts Antiviral Activity by Inhibiting the Expression of HSV-1 Viral Genes UL8 and UL52.

Viruses 2022 Jun 13;14(6). Epub 2022 Jun 13.

Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Two-thirds of the world's population is infected with HSV-1, which is closely associated with many diseases, such as Gingival stomatitis and viral encephalitis. However, the drugs that are currently clinically effective in treating HSV-1 are Acyclovir (ACV), Ganciclovir, and Valacyclovir. Due to the widespread use of ACV, the number of drug-resistant strains of ACV is increasing, so searching for new anti-HSV-1 drugs is urgent. Read More

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Homology Modeling and Molecular Docking Approaches for the Proposal of Novel Insecticides against the African Malaria Mosquito ().

Molecules 2022 Jun 15;27(12). Epub 2022 Jun 15.

"Coriolan Dragulescu" Institute of Chemistry, 24 M. Viteazu Ave, 300223 Timisoara, Romania.

Vector-borne infectious diseases are responsible for the deaths of over 700,000 people annually, than 400,000 of them resulting from malaria. The mosquito is one of the dominant vector species of human malaria transmission. A significant issue of the conventional insecticides which target the arthropod borne infectious diseases is their induced resistance. Read More

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TP-CSO: A Triptolide Prodrug for Pancreatic Cancer Treatment.

Molecules 2022 Jun 8;27(12). Epub 2022 Jun 8.

Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China.

Triptolide (TP) is a potential drug candidate for the treatment of cancer, but its use was hampered by its systemic toxicity and poor water solubility. Hence, a TP-CSO prodrug was synthesized by conjugating TP to chitosan oligosaccharide (CSO), and characterized by H NMR, FTIR, DSC and XRD analyses. The TP-CSO containing about 4 wt% of TP exhibited excellent water solubility (15 mg/mL) compared to TP (0. Read More

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Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in .

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

School of Pharmacy, Lanzhou University, Lanzhou 730000, China.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world. However, there is no effective drug to cure it. Caesalmin C is a cassane-type diterpenoid abundant in (Linn. Read More

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Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries.

Int J Mol Sci 2022 Jun 7;23(12). Epub 2022 Jun 7.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The increased concern regarding the reduction in female fertility and the impressive numbers of women undergoing fertility treatment support the existence of environmental factors beyond inappropriate programming of developing ovaries. Among these factors are pyrethroids, which are currently some of the most commonly used pesticides worldwide. The present study was performed to investigate the developmental effects of the pyrethroid-based insecticide allethrin on ovarian function in rat offspring in adulthood. Read More

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Reduced concentrations and toxicity of sediment-associated pesticides from vegetable planting field to surrounding waterways: Impacts of chemical properties and intrinsic toxicity.

J Hazard Mater 2022 Aug 3;436:129292. Epub 2022 Jun 3.

School of Environment and Guangdong Provincial Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China.

Pesticides from agricultural activities transfer to surrounding waterways, jeopardizing aquatic ecosystem. To better characterize transfer of pesticide residues and toxicity, a batch of pesticides were analyzed in 22 sediment samples collected from the ditches (< 5 m away from field) and receiving streams nearby a vegetable planting area, South China. Sum concentrations of pesticides in ditch sediments (152 ± 121 ng/g dry wt. Read More

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Low temperature tolerance is depressed in wild-type and abscisic acid-deficient mutant barley grown in Cd-contaminated soil.

J Hazard Mater 2022 05 15;430:128489. Epub 2022 Feb 15.

Key Laboratory of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Science, Changchun 130102, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; CAS Engineering Laboratory for Eco-agriculture in Water Source of Liaoheyuan, Chinese Academy of Science, Changchun 130102, China. Electronic address:

The accumulation of heavy metals in soil, especially cadmium (Cd), may influence the tolerance of crops to other abiotic stress, such as low temperature. In this study, the low temperature tolerance of abscisic acid (ABA)-deficient mutant (Az34) barley and its wild-type (WT) irrigated with Cd solution (1 g L) was tested. It was found that Cd aggravated the destruction of chloroplast ultrastructure and disturbed the ion homeostasis under low temperature. Read More

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Emetic Response to T-2 Toxin Correspond to Secretion of Glucagon-like Peptide- Amide and Glucose-Dependent Insulinotropic Polypeptide.

Toxins (Basel) 2022 Jun 2;14(6). Epub 2022 Jun 2.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

The T-2 toxin, a major secondary metabolite of , is considered a great risk to humans and animals due to its toxicity, such as inducing emesis. The mechanism of emesis is a complex signal involving an imbalance of hormones and neurotransmitters, as well as activity of visceral afferent neurons. The T-2 toxin has been proven to induce emesis and possess the capacity to elevate expressions of intestinal hormones glucagon-like peptide- (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), both of which are important emetic factors. Read More

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Glucose-Dependent Insulinotropic Polypeptide and Substance P Mediate Emetic Response Induction by Masked Trichothecene Deoxynivalenol-3-Glucoside through Ca Signaling.

Toxins (Basel) 2022 May 27;14(6). Epub 2022 May 27.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

Deoxynivalenol (DON), the most naturally-occurring trichothecenes, may affect animal and human health by causing vomiting as a hallmark of food poisoning. Deoxynivalenol-3-glucoside (D3G) usually co-occurs with DON as its glucosylated form and is another emerging food safety issue in recent years. However, the toxicity of D3G is not fully understood compared to DON, especially in emetic potency. Read More

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Chemical Profiles and Insecticidal Potential of Essential Oils Isolated from Four Species against (F.).

Plants (Basel) 2022 Jun 14;11(12). Epub 2022 Jun 14.

Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.

Although chemical pesticides have been efficiently used to manage insect pest, their overuse has led to environmental contamination and threats to human health, enticing researchers to introduce eco-friendly and effective agents. In this study, the insecticidal effectiveness of essential oils isolated from species, including , , , and , was evaluated against the adults of . The terpenes -cymene, 1,8-cineole, linalool, α-terpineol, and carvacrol were the prominent compounds in the hydrodistilled essential oils. Read More

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Evaluation of Cellular Uptake and Removal of Chlorpropham in the Treatment of for Phytoene Production.

Mar Drugs 2022 May 30;20(6). Epub 2022 May 30.

School of Science, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.

Chlorpropham is a carbamate herbicide that inhibits cell division and has been widely used as a potato sprout suppressant. Recently we showed that the microalga treated with chlorpropham massively accumulated the colourless carotenoids phytoene and phytofluene. Phytoene and phytofluene are valued for their antioxidant, UV-absorption and skin protectant properties; however, they are present in very low quantities in nature. Read More

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Natural Marine Products: Anti-Colorectal Cancer In Vitro and In Vivo.

Mar Drugs 2022 May 25;20(6). Epub 2022 May 25.

Marine College, Shandong University, Weihai 264209, China.

Colorectal cancer, a malignant tumor with high mortality, has a poor prognosis due to drug resistance and toxicity in clinical surgery and chemotherapy. Thus, finding safer and more efficient drugs for clinical trials is vital and urgent. Natural marine compounds, with rich resources and original chemical structures, are applied widely in anticancer treatments. Read More

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Promising Insecticidal Efficiency of Essential Oils Isolated from Four Cultivated Species in Iran against the Lesser Grain Borer, (F.).

Insects 2022 May 31;13(6). Epub 2022 May 31.

Department of Pre-Clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom 73170, Thailand.

The lesser grain borer, (F.), causes damage to stored grains resulting in both quantitative and qualitative losses. The use of synthetic fumigants in the management of stored-product pests resulted in undesirable side effects such as environmental contamination and threat to human and animal health. Read More

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Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study-INTERACT MESO.

BMJ Open 2022 Jun 22;12(6):e062907. Epub 2022 Jun 22.

Department of Surgical Oncology, Erasmus MC Kanker Instituut, Rotterdam, The Netherlands.

Introduction: Malignant peritoneal mesothelioma (MPM) is a rare, aggressive tumour arising primarily from the peritoneum. The only potentially curative treatment is cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the majority of patients are not eligible to undergo this treatment. Read More

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GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients.

World J Surg Oncol 2022 Jun 22;20(1):212. Epub 2022 Jun 22.

Department of Medical Oncology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.

Background: The link between glutathione S-transferase P1 (GSTP1) c.313A > G polymorphism and chemotherapy-related adverse events remains controversial. The goal of this study was to assess how this variant affected the toxicity of anthracycline-/paclitaxel-based chemotherapy in patients with breast cancer. Read More

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A network meta-analysis for efficacies and toxicities of different concurrent chemoradiotherapy regimens in the treatment of locally advanced non-small cell lung cancer.

BMC Cancer 2022 Jun 20;22(1):674. Epub 2022 Jun 20.

Department of Thoracic Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610044, People's Republic of China.

Background: Concurrent chemoradiotherapy (CCRT) has become the cornerstone of treatment for patients with locally advanced non-small cell lung cancer (LA-NSCLC). The aim of this study was to compare the efficacies and toxicities of different CCRT regimens in the treatment of LA-NSCLC by adopting a network meta-analysis (NMA).

Methods: An exhaustive search of PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) was conducted to identify relevant studies from inception to October 1, 2020. Read More

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Comparative study of oral versus parenteral crocin in mitigating acrolein-induced lung injury in albino rats.

Sci Rep 2022 Jun 17;12(1):10233. Epub 2022 Jun 17.

Human Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Alsharquiah, Egypt.

Acrolein (Ac) is the second most commonly inhaled toxin, produced in smoke of fires, tobacco smoke, overheated oils, and fried foods; and usually associated with lung toxicity. Crocin (Cr) is a natural carotenoid with a direct antioxidant capacity. Yet, oral administration of crocin as a natural rout is doubtful, because of poor absorbability. Read More

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Synergism of deltamethrin with a mixture of short chain fatty acids for toxicity against pyrethroid-resistant and susceptible strains of Tribolium castaneum (Coleoptera: Tenebrionidae).

Pestic Biochem Physiol 2022 Jun 25;184:105132. Epub 2022 May 25.

Department of Entomology, Kansas State University, Manhattan, KS 6506, USA. Electronic address:

Deltamethrin is one of the most effective pyrethroid compounds used in stored product protection to control a wide range of pests. However, the development of resistance to deltamethrin in many pest species has been reported and useful research to overcome this problem is required. The present study investigated the possible synergistic effect of a commercial formulation of a mixture of the short chain fatty acids, octanoic, nonanoic and decanoic acid, in a formulation called "C8910" on the lethal activity of deltamethrin against susceptible (Lab-S) and relatively pyrethroid-resistant (Pyr-R) strains of T. Read More

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The sweet wormwood essential oil and its two major constituents are promising for a safe control measure against fall webworm.

Pestic Biochem Physiol 2022 Jun 16;184:105124. Epub 2022 May 16.

Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran.

The fall webworm, Hyphantria cunea (Drury), is a harmful polyphagous global defoliator. The major chemical components of Artemisia annua essential oil (EO) was found to contain (±)-camphor (16.42%), 1,8-cineole (6. Read More

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Inhibition of mitochondrial permeability transition pore and antioxidant effect of Delta-9-tetrahydrocannabinol reduces aluminium phosphide-induced cytotoxicity and dysfunction of cardiac mitochondria.

Pestic Biochem Physiol 2022 Jun 11;184:105117. Epub 2022 May 11.

Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran; Students Research Committee, Faculty of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

Previous studies have demonstrated that phosphine gas (PH) released from aluminium phosphide (AlP) can inhibit cytochrome oxidase in cardiac mitochondria and induce generation of free radicals, oxidative stress, alteration in antioxidant defense system and cardiotoxicity. Available evidence suggests that cannabinoids have protective effects in the reduction of oxidative stress, mitochondrial and cardiovascular damages. The objective of this study was to evaluate the effect of trans-Δ-9-tetrahydrocannabinol (THC) on AlP-induced toxicity in isolated cardiomyocytes and cardiac mitochondria. Read More

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Biochemical and insecticidal effects of plant essential oils on insecticide resistant and susceptible populations of Musca domestica L. point to a potential cross-resistance risk.

Pestic Biochem Physiol 2022 Jun 6;184:105115. Epub 2022 May 6.

Laboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium. Electronic address:

Essential oils (EOs) can provide important alternatives to chemical insecticides in the control of pests. In this study, 12 EOs of native plant species from Iran were evaluated for their adulticidal activity against the house fly. In addition, we examined the insecticidal activity of Zataria multiflora and Rosmarinus officinalis EOs on adult female house flies from pyrethroid and organophosphate resistant and susceptible populations, using both fumigant and topical bioassays. Read More

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Transcriptome analysis provides insight into deltamethrin-induced fat accumulation in 3T3-L1 adipocytes.

Pestic Biochem Physiol 2022 Jun 6;184:105114. Epub 2022 May 6.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China. Electronic address:

Previously, deltamethrin (a Type-II pyrethroid) has been reported to increase triglyceride (fat) accumulation in adipocytes, while its underlying molecular mechanism is not fully determined. The aim of this study was to further investigate the molecular mechanisms of deltamethrin induced fat accumulation in murine 3T3-L1 adipocytes. Consistent to previous reports, deltamethrin (10 μM) significantly promoted adipogenesis in 3T3-L1 adipocytes. Read More

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Metabolism and antioxidant activity of SlGSTD1 in Spodoptera litura as a detoxification enzyme to pyrethroids.

Sci Rep 2022 Jun 16;12(1):10108. Epub 2022 Jun 16.

Postdoctoral Mobile Station of Crop Science, Henan Agricultural University, Wenhua Road, Jinshui District, Zhengzhou, Henan, China.

Glutathione S-transferase (GSTs) are members of multifunction enzymes in organisms and mostly known for their roles in insecticide resistance by conjugation. Spodoptera litura (Fabricius) is a voracious agricultural pest widely distributed in the world with high resistance to various insecticides. The function of GSTs in the delta group of S. Read More

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A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity.

BMC Biol 2022 Jun 15;20(1):143. Epub 2022 Jun 15.

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.

Background: Zika virus (ZIKV) and dengue virus (DENV) cause microcephaly and dengue hemorrhagic fever, respectively, leading to severe problems. No effective antiviral agents are approved against infections of these flaviviruses, calling for the need to develop potent therapeutics. We previously identified gossypol as an effective inhibitor against ZIKV and DENV infections, but this compound is toxic and not suitable for in vivo treatment. Read More

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Starch-based carriers of paclitaxel: A systematic review of carriers, interactions, and mechanisms.

Carbohydr Polym 2022 Sep 18;291:119628. Epub 2022 May 18.

Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi, 214122, Jiangsu Province, People's Republic of China. Electronic address:

Paclitaxel, a clinical chemotherapy drug commonly used in the past few years, is greatly limited by its low therapeutic index. Starch and its derivatives have gained wide interest from researchers owing to their unique hydrophilic and hydrophobic properties resulting from their various modifications, which exert the effect-enhancing and toxicity-reducing activity to paclitaxel in vivo and in vitro. This review summarizes the research progress toward different kinds of starch-based carriers, whether oral or injectable. Read More

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September 2022

Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches.

BMC Complement Med Ther 2022 Jun 13;22(1):156. Epub 2022 Jun 13.

Centro de Investigaciones y Transferencia Villa María (CIT VM), Instituto Académico Pedagógico de Ciencias Humanas, Universidad Nacional de Villa María, Arturo Jauretche 1555, X5900 Villa María, Córdoba, Argentina.

Introduction: Despite the number of deaths and the significant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side effects and high toxicity for the patient. Therefore, there is an urgent need for safe, low-cost, and effective treatments. Natural products are an important source of bioactive compounds and there is current interest in finding natural bioactive molecules that can be used for treating these parasitic diseases. Read More

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Molecular Targets of Nimbolide for Anti-Cancer Therapy: An Updated Review.

J Environ Pathol Toxicol Oncol 2022 ;41(2):69-88

Department of Pharmacology, Cancer and Stem Cell Lab, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India.

Cancer is a major cause of death worldwide with an increasing incidence rate and is considered a major public health problem. Distance metastasis to other tissues, high toxicity, and drug resistance of cancer cells to chemotherapy demand novel therapeutic approaches to treat cancer. Natural compounds from medicinal plants have been studied for therapeutic use in various malignancies. Read More

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Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass.

J Vis Exp 2022 05 27(183). Epub 2022 May 27.

Institute for Cannabis Research, Colorado State University-Pueblo;

Industrial hemp (Cannabis spp.) has many compounds of interest with potential medical benefits. Of these compounds, cannabinoids have come to the center of attention, specifically acidic cannabinoids. Read More

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