28,998 results match your criteria Toxicity Terpene


Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms.

Biomed Pharmacother 2019 Feb 16;112:108582. Epub 2019 Feb 16.

Department of Antibiotics, Federal University of Pernambuco, Cidade Universitária, Av. Arthur de Sá, S/N, 50670-901, Recife, PE, Brazil. Electronic address:

Objective: Avicennia schaueriana Stapf is an endemic mangrove species widely used by traditional Brazilian communities as a folk remedy for the treatment of rheumatism, ulcers, and skin wounds. The aim of the present study was to evaluate the gastroprotective potential of the ethyl acetate extract from the leaves of A. schaueriana (As-AcOEt). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.043DOI Listing
February 2019

Proteasome inhibition by MG-132 protects against deltamethrin-induced apoptosis in rat hippocampus.

Life Sci 2019 Mar 26;220:76-83. Epub 2019 Jan 26.

Department of Toxicology, MOE Key Laboratory of Environmental and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

Aims: Deltamethrin (DM), a type II synthetic pyrethroid insecticide, is widely used in agriculture and home pest control. The evaluation of their toxic effects is of major concern to public health. However, the molecular mechanism of DM-induced neurodegenerative disease is still far from clear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.041DOI Listing

Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba.

Sci Total Environ 2019 Mar 2;657:926-937. Epub 2018 Dec 2.

Department of Biology, Aveiro University, Campus de Santiago, 3810-193 Aveiro, Portugal; Centre for Environmental and Marine Studies (CESAM), Campus de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In the last years the environmental presence of pharmaceuticals has gained increasing attention. Research data show that these compounds can cause toxicological effects in different species of fish, mollusks and macroinvertebrates. However, the literature is scarce in terms of ecotoxicity data especially focusing on plants as test organisms. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.002DOI Listing

Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance.

Authors:
David O Kennedy

Sports Med 2019 Feb;49(Suppl 1):39-58

Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK.

Subjective alertness and optimal cognitive function, including in terms of attention, spatial/working memory and executive function, are intrinsic to peak performance in many sports. Consumption of a number of plant-derived 'secondary metabolite' phytochemicals can modulate these psychological parameters, although there is a paucity of evidence collected in a sporting context. The structural groups into which these phytochemicals fall-phenolics, terpenes and alkaloids-vary in terms of the ecological roles they play for the plant, their toxicity and the extent to which they exert direct effects on brain function. Read More

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http://dx.doi.org/10.1007/s40279-018-1007-0DOI Listing
February 2019
3 Reads

New Perspectives on the Efficacy of Gallic Acid in Cosmetics & Nanocosmeceuticals.

Curr Pharm Des 2019 Jan 18. Epub 2019 Jan 18.

College of Pharmacy, Manchester University, Fort Wayne, IN 46845. United States.

Background: Gallic acid (GA - 3,4,5-trihydroxybenzoic acid), a phenolic phytochemical, is an ubiquitous secondary metabolite found in most plants, with appreciable concentrations in grapes seed, rose flowers, sumac, oak and witch hazel. GA often results from the hydrolysis of terpenes and the polyphenol tannic acid.

Applications: It exhibits powerful antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. Read More

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http://dx.doi.org/10.2174/1381612825666190118150614DOI Listing
January 2019
6 Reads

Acute Toxicity and Sub-lethal Effects of the Essential Oil of Aristolochia trilobata and Its Major Constituents on Nasutitermes corniger (Termitidae: Nasutitermitinae).

Neotrop Entomol 2019 Jan 12. Epub 2019 Jan 12.

Programa de Pós-Graduação em Agricultura e Biodiversidade (PPGAGRI), Univ Federal de Sergipe, Av. Marechal Rondon, s/n, Rosa Elze, 49100-000, São Cristóvão, SE, Brasil.

Nasutitermes corniger (Motschulsky, 1855) (Termitidae: Nasutitermitinae) is an important pest in urban environments and bioinsecticides can be an alternative to its control. Here, we determined the toxicity and repellence of the essential oil (EO) prepared from stems of Aristolochia trilobata L. (Aristolochiaceae) and its major constituents on N. Read More

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http://dx.doi.org/10.1007/s13744-018-0665-9DOI Listing
January 2019

The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell.

Pan Afr Med J 2018 8;30:264. Epub 2018 Aug 8.

Department of Dermatology and Venerology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Introduction: Keloids characterized by fibroblast hyperproliferation and depositions of collagen which similar to cancer cells. Tagitinin C is a class of sesquiterpene lactones (SLS) was isolated from the leaves of the moon flower (Hemsley) A. Gray. Read More

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http://www.panafrican-med-journal.com/content/article/30/264
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http://dx.doi.org/10.11604/pamj.2018.30.264.9994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317294PMC
January 2019
5 Reads

Mechanical-physicochemical properties and biocompatibility of catechin-incorporated adhesive resins.

J Appl Oral Sci 2019 Jan 7;27:e20180111. Epub 2019 Jan 7.

Universidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Departamento de Odontologia Restauradora, Grupo Acadêmico de Pesquisa Clínica, São José dos Campos, São Paulo, Brasil.

Objectives: Several anti-proteolytic dentin therapies are being exhaustively studied in an attempt to reduce dentin bond degradation and improve clinical performance and longevity of adhesive restorations. This study assessed the effect of epigallocatechin-3-gallate (EGCG) on long-term bond strength when incorporated into adhesives.

Material And Methods: Adhesive systems were formulated with EGCG concentrations of 0 wt%: (no EGCG; control); 0. Read More

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http://dx.doi.org/10.1590/1678-7757-2018-0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322639PMC
January 2019
3 Reads

Essential oils from Varronia curassavica (Cordiaceae) accessions and their compounds (E)-caryophyllene and α-humulene as an alternative to control Dorymyrmex thoracius (Formicidae: Dolichoderinae).

Environ Sci Pollut Res Int 2019 Jan 9. Epub 2019 Jan 9.

Universidade Federal de Sergipe, Cidade Universitária Professor José Aloísio de Campos, Av. Marechal Rondon s/n, Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.

The process of urbanization of natural environments has dramatically increased the incidence of pest insects. To control these organisms in urban environments, the last decades have been marked by an increase in the use of synthetic insecticides. However, the intensive and indiscriminate use of synthetic insecticides has provoked a series of environmental problems and human health. Read More

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http://link.springer.com/10.1007/s11356-018-4044-1
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http://dx.doi.org/10.1007/s11356-018-4044-1DOI Listing
January 2019
7 Reads

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

Pharm Res 2019 Jan 7;36(2):33. Epub 2019 Jan 7.

Department of Pharmacy &Pharmacology, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, the Netherlands.

Purpose: Limited available data suggest that older patients are more prone to develop paclitaxel-induced toxicity than their younger peers. It remains unclear whether this is related to age-dependent pharmacokinetics (PK) of paclitaxel. Primary objective of this study was to determine the influence of older age on the PK of paclitaxel. Read More

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http://dx.doi.org/10.1007/s11095-018-2563-6DOI Listing
January 2019
2 Reads

Cellular effects of paclitaxel-loaded iron oxide nanoparticles on breast cancer using different 2D and 3D cell culture models.

Int J Nanomedicine 2019 21;14:161-180. Epub 2018 Dec 21.

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Erlangen, Germany,

Background: Magnetic drug targeting (MDT) is an effective alternative for common drug applications, which reduces the systemic drug load and maximizes the effect of, eg, chemotherapeutics at the site of interest. After the conjugation of a magnetic carrier to a chemotherapeutic agent, the intra-arterial injection into a tumor-afferent artery in the presence of an external magnetic field ensures the accumulation of the drug within the tumor tissue.

Materials And Methods: In this study, we used superparamagnetic iron oxide nanoparticles (SPIONs) coated with lauric acid and human serum albumin as carriers for paclitaxel (SPION). Read More

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http://dx.doi.org/10.2147/IJN.S187886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306067PMC
February 2019
2 Reads

Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.

Chem Biol Interact 2019 Feb 3;300:18-26. Epub 2019 Jan 3.

Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China. Electronic address:

Chronic pancreatitis is characterized by pancreatic fibrosis, associated with excessive activation of pancreatic stellate cells (PSCs) and increased expression of transforming growth factor-β1 (TGF-β1). Recently, our studies have shown that autophagy inhibitor could inhibit PSCs activation and reduce collagen secretion. Saikosaponin d (SSd), the major active component of bupleurum falcatum (a medicinal plant), has anti-fibrosis effects in liver. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183103
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http://dx.doi.org/10.1016/j.cbi.2019.01.005DOI Listing
February 2019
5 Reads

Untargeted LC-MS based C labelling provides a full mass balance of deoxynivalenol and its degradation products formed during baking of crackers, biscuits and bread.

Food Chem 2019 May 11;279:303-311. Epub 2018 Dec 11.

Center for Analytical Chemistry, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad-Lorenz-Str. 20, 3430 Tulln, Austria; Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road, Belfast BT7 1NN, Northern Ireland, United Kingdom.

Deoxynivalenol (DON) is considered to be one of the most important contaminants in cereals and food commodities produced thereof. So far it is not clear i) to which extent DON is degraded during baking and ii) if a degradation results in reduced toxicity. We have elucidated the fate of DON during baking of crackers, biscuits and bread, which were produced from fortified dough and processed under pilot plant conditions. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.11.150DOI Listing
May 2019
1 Read

Resistance to insecticides and synergistic and antagonistic effects of essential oils on dimefluthrin toxicity in a field population of Culex quinquefasciatus Say.

Ecotoxicol Environ Saf 2019 Mar 30;169:928-936. Epub 2018 Nov 30.

Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou 510642, PR China. Electronic address:

In this work, we firstly tested five spatial repellent pyrethroids, meperfluthrin, dimefluthrin, heptafluthrin, metofluthrin and transfluthrin, to determine the susceptibility of pyrethroids to field strains of Culex quinquefasciatus using adult topical bioassay. The results showed that though field strains exhibited the highest resistance to dimefluthrin among the selected five pyrethroids, it still can be considered low resistance in the scale of Cui et al. (2006; 2007). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183126
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http://dx.doi.org/10.1016/j.ecoenv.2018.11.115DOI Listing
March 2019
9 Reads

Seven herbs against the stored product insect: Toxicity evidence and the active sesquiterpenes from Atractylodes lancea.

Ecotoxicol Environ Saf 2019 Mar 29;169:807-813. Epub 2018 Nov 29.

Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, NO.19 Xinjiekouwai Street, Beijing 100875, China. Electronic address:

In this work, the essential oils (EO) were extracted from seven typical Chinese herbs, and their repellent and contact toxicities against Tribolium castaneum adults (red flour beetles) were evaluated. The experimental results showed that the above EOs presented the various levels of repellent and contact toxicities. The EOs extracted from A. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.095DOI Listing
March 2019
1 Read

l-arginine protects against T-2 toxin-induced male reproductive impairments in mice.

Theriogenology 2019 Mar 14;126:249-253. Epub 2018 Dec 14.

College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan, 471023, China.

l-arginine is beneficial for reproductive health; however, whether l-arginine may confer protection against T-2 toxin-induced reproductive impairment is not known. To address this, we used a mice model treated with T-2 toxin to investigate protective effects of l-arginine. Experimentally, we pre-treated mice with designed diet of l-arginine supplementation prior to the T-2 toxin-injected intraperitoneally exposure and then assessed semen quality, fertility and serum testosterone concentration. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2018.12.024DOI Listing
March 2019
3 Reads

Chemical composition and oral toxicity assessment of Anisophyllea boehmii kernel oil: Potential source of new edible oil with high tocopherol content.

Food Chem 2019 Apr 30;278:795-804. Epub 2018 Nov 30.

Laboratory of Biology of Plants and Microorganisms, Department of Biology, Faculty of Science, University Mohammed First, 717, 60000 Oujda, Morocco.

Anisophyllea boehmii is an indigenous and wild species in Burundi. Its fruits are edible and commercialized in local markets. This study investigates chemical quality, composition and toxicity test of A. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.11.112DOI Listing
April 2019
1 Read

The synergistic potential of azole fungicides does not directly correlate to the inhibition of cytochrome P450 activity in aquatic invertebrates.

Aquat Toxicol 2019 Feb 14;207:187-196. Epub 2018 Dec 14.

Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg, Denmark. Electronic address:

The ability of azole fungicides to inhibit cytochrome P450 dependent metabolism is proposed to be the main mechanism for their synergizing effect on pyrethroid insecticide toxicity in aquatic invertebrates. This study investigates the correlation between inhibition strength and synergistic potential of azole fungicides in the crustacean Daphnia magna and the insect larvae Chironomus riparius. Inhibition strength was measured in vivo toward the cytochrome P450 catalysed conversion of 7-ethoxycoumarin to 7-hydroxycoumarin (ECOD). Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.12.010DOI Listing
February 2019
5 Reads

Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice.

BMC Vet Res 2018 Dec 22;14(1):415. Epub 2018 Dec 22.

National Research Center for Veterinary Vaccine Engineering and Technology of China, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.

Background: Vaccination is the principal strategy for prevention and control of diseases, and adjuvant use is an effective strategy to enhance vaccine efficacy. Traditional mineral oil-based adjuvants have been reported with post-immunization reactions. Developing new adjuvant formulations with improved potency and safety will be of great value. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1719-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303909PMC
December 2018
6 Reads

In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives.

Malar J 2018 Dec 19;17(1):482. Epub 2018 Dec 19.

Laboratório de Biologia da Malária e Toxoplasmose - LABMAT, Departmento de Microbiologia e Parasitologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Background: Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets because the pathway is different in several steps when compared with the human host. Naphthoquinone derivatives have been described as potentially promising for the development of anti-malarial leader molecules. In view of that, the focus in this work is twofold: first, evaluate the in vitro naphthoquinone antiplasmodial activity and cytotoxicity; secondly, investigate one possible action mechanism of two derivatives of hydroxy-naphthoquinones. Read More

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http://dx.doi.org/10.1186/s12936-018-2615-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300878PMC
December 2018
1 Read

Stability, Cytotoxicity, and Retinal Pigment Epithelial Cell Binding of Hyaluronic Acid-Coated PLGA Nanoparticles Encapsulating Lutein.

AAPS PharmSciTech 2018 Dec 17;20(1). Epub 2018 Dec 17.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Ongkarak, Nakhon Nayok, 26120, Thailand.

The application of lutein was limited due to water insolubility and susceptible to heat and light degradation. In this study, hyaluronic acid (HA)-coated PLGA nanoparticles encapsulating lutein were fabricated by a solvent displacement method to improve the physicochemical properties and the stability of lutein. A biphasic release profile of lutein was observed, following zero-order release kinetics. Read More

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http://dx.doi.org/10.1208/s12249-018-1256-0DOI Listing
December 2018

Activation of polymeric nanoparticle intracellular targeting overcomes chemodrug resistance in human primary patient breast cancer cells.

Int J Nanomedicine 2018 29;13:8153-8164. Epub 2018 Nov 29.

The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA,

Background: Successfully overcoming obstacles due to anticancer drugs' toxicity and achieving effective treatment using unique nanotechnology is challenging. The complex nature of breast tumors is mainly due to chemoresistance. Successful docetaxel (DTX) delivery by nanoparticles (NPs) through inhibition of multidrug resistance (MDR) can be a bridge to enhance intracellular dose and achieve higher cytotoxicity for cancer cells. Read More

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http://dx.doi.org/10.2147/IJN.S182184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278841PMC
January 2019
2 Reads

Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.

Eur J Med Chem 2019 Feb 7;163:560-568. Epub 2018 Dec 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in MDCK (Madin-Darby canine kidney) cells were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183104
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http://dx.doi.org/10.1016/j.ejmech.2018.12.006DOI Listing
February 2019
18 Reads

Inflammation and oxidative stress are key mediators in AKB48-induced neurotoxicity in vitro.

Toxicol In Vitro 2019 Mar 12;55:101-107. Epub 2018 Dec 12.

Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Beyazıt, 34116 Istanbul, Turkey.

Synthetic cannabinoids were introduced into market in early 2000s; since these "legal highs" are dramatically popular among youth, it becomes a deadly problem. Synthetic cannabinoids have high affinity to cannabinoid receptors; leading to various clinical symptoms. AKB48 (Apinaca) has been classified as a third-generation synthetic cannabinoid for the first time in 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183081
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http://dx.doi.org/10.1016/j.tiv.2018.12.005DOI Listing
March 2019
8 Reads

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.

Nat Commun 2018 12 13;9(1):5293. Epub 2018 Dec 13.

Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More

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http://www.nature.com/articles/s41467-018-07688-8
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http://dx.doi.org/10.1038/s41467-018-07688-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294255PMC
December 2018
18 Reads

Capecitabine monotherapy in advanced breast cancer resistant to anthracycline and taxane: A meta-analysis.

J Cancer Res Ther 2018 Dec;14(Supplement):S957-S963

Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

Background: Capecitabine monotherapy is usually used for advanced breast cancer (ABC) resistant to anthracycline and taxane, but there are still many other options too. Our meta-analysis assessed whether capecitabine monotherapy was superior or noninferior to the other regimens in ABC pretreated with anthracycline and taxane.

Materials And Methods: PubMed databases and abstracts from the proceedings of American Society of Clinical Oncology and San Antonio Breast Cancer Symposium were searched for randomized controlled trials that compared capecitabine monotherapy with other regimens for ABC progression after anthracycline- and taxane-treatment. Read More

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http://dx.doi.org/10.4103/0973-1482.187384DOI Listing
December 2018
1 Read

Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.

J Stroke Cerebrovasc Dis 2019 Jan 24;28(1):175-184. Epub 2018 Oct 24.

Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China. Electronic address:

Background: Stevioside, isolated from the herb Stevia rebaudiana, has been widely used as a food sweetener all over the world. Isosteviol Sodium (STV-Na), an injectable formulation of isosteviol sodium salt, has been proved to possess much greater solubility and bioavailability and exhibit protective effects against cerebral ischemia injury in vivo by inhibiting neuron apoptosis. However, the underlying mechanisms of the neuroprotective effects STV-Na are still not completely known. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183052
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.020DOI Listing
January 2019
6 Reads

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

J Mol Neurosci 2019 Jan 7;67(1):62-71. Epub 2018 Dec 7.

Laboratory of Molecular Pharmacology, Jilin Provincial Key Laboratory of BioMacromolecules of Chinese Medicine, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.

The objective of this study was to investigate the neuroprotective and antioxidant effects of ginsenoside compound K (CK) in a model of scopolamine hydrobromide-induced, memory-impaired mice. The role of CK in the regulation of amyloid β (Aβ) and its capacity to activate the Nrf2/Keap1 signaling pathway were also studied due to their translational relevance to Alzheimer's disease. The Morris water maze was used to assess spatial memory functions. Read More

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http://dx.doi.org/10.1007/s12031-018-1210-3DOI Listing
January 2019
2 Reads

Recombinant Manganese Peroxidase Reduces A2E Burden in Age-Related and Stargardt's Macular Degeneration Models.

Rejuvenation Res 2018 Dec;21(6):560-571

1 Ichor Therapeutics, Inc., Lafayette, New York.

Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. Read More

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http://dx.doi.org/10.1089/rej.2018.2146DOI Listing
December 2018
13 Reads

Therapeutic potential of Panax ginseng and its constituents, ginsenosides and gintonin, in neurological and neurodegenerative disorders: a patent review.

Expert Opin Ther Pat 2019 Jan 11;29(1):55-72. Epub 2018 Dec 11.

c Pharmaceutical Research Center, Pharmaceutical Technology Institute , Mashhad University of Medical Sciences , Mashhad , Iran.

Introduction: Ginseng, Panax ginseng, has been used for various diseases and proven its great efficacy in managing central nervous system diseases. Area covered: This article covers the therapeutic potential of patents on ginseng and its active constituents to develop therapies for neurodegenerative and neurological disorders, since 2010. The literature review was provided using multiple search engines including Google Patent, Espacenet and US Patent in the field of neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, cognitive, and neurological disorders. Read More

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http://dx.doi.org/10.1080/13543776.2019.1556258DOI Listing
January 2019
11 Reads

Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.

Lancet 2019 01 30;393(10167):156-167. Epub 2018 Nov 30.

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, National Institute of Health Research Biomedical Research Centre, London, UK.

Background: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)31999-8DOI Listing
January 2019
4 Reads

Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research.

Environ Toxicol Pharmacol 2019 Jan 23;65:31-39. Epub 2018 Nov 23.

Laboratory for Ecotoxicology - LECOTOX, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg D. Obradovica 2, 21000, Novi Sad, Serbia.

Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183042
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http://dx.doi.org/10.1016/j.etap.2018.11.007DOI Listing
January 2019
6 Reads

Salicylic acid and jasmonic acid restrains nickel toxicity by ameliorating antioxidant defense system in shoots of metallicolous and non-metallicolous Alyssum inflatum Náyr. Populations.

Plant Physiol Biochem 2019 Feb 14;135:450-459. Epub 2018 Nov 14.

Laboratory of Plant Physiology, Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran.

The presence of heavy metals in the soils is undoubtedly one of the prime abiotic stresses in the world. There are a considerable amount of plant yield losses because of heavy metal stress. The goal of this study was to assess the morphological, physiological and biochemical changes in Alyssum inflatum Nyár. Read More

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http://dx.doi.org/10.1016/j.plaphy.2018.11.015DOI Listing
February 2019

Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells.

Chem Biol Interact 2019 Feb 24;299:15-26. Epub 2018 Nov 24.

Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. Electronic address:

Many reports demonstrated that aluminum maltolate (Almal) has potential toxicity to human and animal. Our study has demonstrated that Almal can induce oxidative damage and apoptosis in PC12 cells and SH-SY5Y Cells, two in vitro models of neuronal cells. Hyperforin (HF) is a well-known antioxidant, anti-inflammatory, anti-amyloid and anti-depressant compound extracted from Hypericum perforatum extract. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797173115
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http://dx.doi.org/10.1016/j.cbi.2018.11.016DOI Listing
February 2019
12 Reads

Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.

Nat Commun 2018 11 26;9(1):4982. Epub 2018 Nov 26.

MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, W2 1PG, UK.

Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Read More

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http://www.nature.com/articles/s41467-018-07357-w
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http://dx.doi.org/10.1038/s41467-018-07357-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255894PMC
November 2018
14 Reads

Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.

Phytochemistry 2019 Feb 24;158:77-85. Epub 2018 Nov 24.

Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address:

Six previously undescribed labdane diterpenoids, frullanians A-F, along with five known diterpenoids, were isolated from the Chinese liverwort Frullania hamatiloba Stephani. Their structures were determined using NMR data, electronic circular dichroism (ECD) calculations as well as the single crystal X-ray diffraction measurement. NAD(P)H: QR (quinone reductase) assay demonstrated that frullanian D and four known compounds displayed antioxidant effect mediated via Nrf2 (Nuclear factor-erythroid 2-related factor 2) induction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00319422183053
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http://dx.doi.org/10.1016/j.phytochem.2018.11.002DOI Listing
February 2019
15 Reads
2.547 Impact Factor

Aging and retinoid X receptor agonists on masculinization of female Pomacea canaliculata, with a critical appraisal of imposex evaluation in the Ampullariidae.

Ecotoxicol Environ Saf 2019 Mar 24;169:573-582. Epub 2018 Nov 24.

IHEM, Universidad Nacional de Cuyo, CONICET, Casilla de Correo 33, 5500-Mendoza, Argentina; Universidad Nacional de Cuyo, Facultad de Ciencias Médicas, Instituto de Fisiología, Casilla de Correo 33, 5500-Mendoza, Argentina; Universidad Nacional de Cuyo, Facultad de Ciencias Exactas y Naturales, Departamento de Biología, Casilla de Correo 33, 5500-Mendoza, Argentina.

Ampullariidae are unique among gastropods in that females normally show a primordium of the copulatory apparatus (CApp). The aims of this study were (a) to quantitatively evaluate the development and growth of the female CApp with age; (b) to compare the effects of RXR and PPARγ agonists in adult females of known age and (c) to explore the effect of masculinizing RXR agonists on the expression of RXR in the CApp. It was found that the CApp grows and develops with age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183110
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http://dx.doi.org/10.1016/j.ecoenv.2018.10.096DOI Listing
March 2019
2 Reads

Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos.

Chemosphere 2019 Mar 15;218:273-281. Epub 2018 Nov 15.

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

Ultraviolet (UV) filters are widely used in personal care products and due to their lipophilicity these chemicals tend to bioaccumulate in the aquatic biota. 4-Methylbenzylidene camphor (4-MBC) is one of the most used UV-filters, and it is commonly detected in freshwater fish tissues. This substance is suspected to be an endocrine disruptor due to its interaction with Hypothalamus-Pituitary-Gonadal (HPG) and HP-Thyroid (HPT)-axis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183220
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http://dx.doi.org/10.1016/j.chemosphere.2018.11.096DOI Listing
March 2019
23 Reads

Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo through up-regulating miR-124.

Life Sci 2019 Jan 22;216:147-155. Epub 2018 Nov 22.

School of Public Health Jilin University, Changchun 130021, Jilin, China. Electronic address:

Aims: Spinal cord injury (SCI) is a damage of spinal cord caused by trauma or diseases. Here, we explored the effects of tanshinone IIA (Tan IIA) on SCI oxidative damage in vitro and in vivo.

Materials And Methods: In vitro, PC-12 cells were treated by HO to stimulate oxidative injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.046DOI Listing
January 2019
8 Reads
2.702 Impact Factor

A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins.

Phytomedicine 2018 Nov 17;50:73-87. Epub 2018 Sep 17.

School of Advanced Medical Science, Shandong University, 44 Wenhuaxilu road, Jinan, Shandong 250012, China; The Second Hospital of Shandong University, 247 Beiyuan Ave, Jinan, Shandong 250033, China; Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, Shandong 250355, China. Electronic address:

Background: Radix Bupleuri (RB) has been widely used in Chinese Traditional Medicine for over 2000 years and is currently marketed in China as Chai-Hu-Shu-Gan tablets and Xiao-Yao-Wan tablets. Saikosaponins (SSs, especially SSa, SSc and SSd), as the major bioactive compounds in RB, represent anti-inflammatory, anti-tumor, anti-oxidant, anti-viral and hepatoprotective effects.

Purpose: To summarize recent findings regarding to the extraction, detection, biosynthesis, metabolism, pharmacological/toxicological effects of SSs. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.09.174DOI Listing
November 2018
10 Reads

Thymol exposure mediates pro-oxidant shift by regulating Nrf2 and apoptotic events in zebrafish (Danio rerio) embryos.

Environ Toxicol Pharmacol 2019 Jan 7;65:1-8. Epub 2018 Nov 7.

Department of Biotechnology, College of Engineering, Daegu University Kyoungsan, Kyoungbook 712-714, Republic of Korea. Electronic address:

The biochemical process of oxidative stress is an integral mechanism of chemical toxicity, contributing to complex pathological disorders. Thymol (THY) has a wide range of therapeutic applications for several ailments, although a better understanding of signaling cues regulated by this compound is needed to address the mechanism of its action. To better perceive the mode of action, we investigated the potential impact of THY on zebrafish embryos, with special emphasis on ROS biogenesis. Read More

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http://dx.doi.org/10.1016/j.etap.2018.11.001DOI Listing
January 2019
6 Reads

Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review.

Food Chem Toxicol 2019 Jan 16;123:459-469. Epub 2018 Nov 16.

Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology (DFS), Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil. Electronic address:

Many diseases, such as inflammatory and central nervous system disorders, currently have a limited number of effective side-effect free treatments. Citronellol (CT) is a monoterpene alcohol present in the essential oil of several plants used in cooking and traditional medicine, such as those of the genus Cymbopogon and Citrus, with pharmacological activities already described in the literature. The aim of this review was to summarize the pharmacological activities already attributed to CT that could be used in treatments for humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183083
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http://dx.doi.org/10.1016/j.fct.2018.11.030DOI Listing
January 2019
10 Reads

CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation.

PLoS Negl Trop Dis 2018 11 19;12(11):e0006933. Epub 2018 Nov 19.

Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York, United States of America.

Aedes aegypti poses a serious risk to human health due to its wide global distribution, high vector competence for several arboviruses, frequent human biting, and ability to thrive in urban environments. Pyrethroid insecticides remain the primary means of controlling adult A. aegypti populations during disease outbreaks. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006933
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http://dx.doi.org/10.1371/journal.pntd.0006933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277111PMC
November 2018
16 Reads

Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice.

Life Sci 2019 Jan 14;216:215-226. Epub 2018 Nov 14.

Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense (UNESC), 88006-000 Criciúma, SC, Brazil; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil. Electronic address:

Diosmetin is an O‑methylated flavone found naturally in citrus fruit, and it was identified in Amphilophium crucigerum (L.), a plant popularly used as an analgesic. This compound had different pharmacological effects and presented a chemical structure like the flavonoid eriodyctiol that exhibited antinociceptive effects by TRPV1 antagonism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183073
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http://dx.doi.org/10.1016/j.lfs.2018.11.029DOI Listing
January 2019
11 Reads

Protective effect of Myrsine parvifolia plant extract against the inflammatory process induced by Bothrops jararaca snake venom.

Toxicon 2019 Jan 14;157:66-76. Epub 2018 Nov 14.

Laboratório de Tecnologia de Produtos Naturais, Departamento de Tecnologia Farmacêutica, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.

Accidents involving snakes from the genus Bothrops sp. constitute the most important cause of snake envenomation in Brazil. The Myrsine genus has been reported to be used in folk medicine against snakebites. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183101
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http://dx.doi.org/10.1016/j.toxicon.2018.11.289DOI Listing
January 2019
12 Reads

Tocolytic activity of the Lippia alba essential oil and its major constituents, citral and limonene, on the isolated uterus of rats.

Chem Biol Interact 2019 Jan 14;297:155-159. Epub 2018 Nov 14.

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil. Electronic address:

The species Lippia alba (Mill.) N. E. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183091
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http://dx.doi.org/10.1016/j.cbi.2018.11.006DOI Listing
January 2019
15 Reads

Tabernaemontana catharinensis leaves exhibit topical anti-inflammatory activity without causing toxicity.

J Ethnopharmacol 2019 Mar 13;231:205-216. Epub 2018 Nov 13.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Background: Tabernaemontana catharinensis, popularly known as snake skin, has been empirically used as an anti-inflammatory to treat cutaneous skin disorders. However, no study proves its effectiveness as a topical anti-inflammatory.

Study Design: We investigated the topical anti-inflammatory effect of T. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183329
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http://dx.doi.org/10.1016/j.jep.2018.11.021DOI Listing
March 2019
14 Reads

Protective efficacy of crocetin and its nanoformulation against cyclosporine A-mediated toxicity in human embryonic kidney cells.

Life Sci 2019 Jan 13;216:39-48. Epub 2018 Nov 13.

Institute of Life Sciences, Bhubaneswar, Odisha, India. Electronic address:

Aim: This study is aimed to formulate crocetin-loaded lipid Nanoparticles (NPs) and to evaluate its antioxidant properties in a cyclosporine A-mediated toxicity in Human Embryonic Kidney (HEK-293) cells in vitro.

Main Methods: Crocetin-loaded NPs were prepared followed by physicochemical characterization. In vitro protective efficacy of crocetin and crocetin loaded NPs was investigated in cyclosporine A-mediated toxicity in HEK-293 cells by assessing free radical scavenging, DNA Nicking, cytotoxicity, intracellular Reactive oxygen species (ROS) inhibition, Mitochondrial membrane potential (MMPs) loss and evaluating the activity and expression of antioxidant enzymes and non-enzyme level. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.027DOI Listing
January 2019
2 Reads

Assessment of endophyte-derived tremorgenic compounds in Ipomoea asarifolia using mouse models.

Toxicon 2018 Dec 12;156:52-60. Epub 2018 Nov 12.

USDA-ARS Poisonous Plant Research Laboratory, Logan, 84341, UT, USA.

Ipomoea asarifolia has been associated with a tremorgenic syndrome in livestock. Recently indole diterpene compounds were identified in I. asarifolia, some of which have been shown to cause a tremorgenic syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183072
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http://dx.doi.org/10.1016/j.toxicon.2018.11.008DOI Listing
December 2018
9 Reads

Nanoparticle albumin bound-paclitaxel for treatment of advanced non-small cell lung cancer: an evaluation of the clinical evidence.

Expert Opin Pharmacother 2019 Jan 15;20(1):95-102. Epub 2018 Nov 15.

a Department of Medical Oncology , Albert Einstein College of Medicine/Montefiore Medical Center , Bronx , NY , USA.

Introduction: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel), a microtubule inhibitor, has demonstrated clinical efficacy in the treatment of advanced non-small cell lung cancer (NSCLC) either as monotherapy or in combination. Nab-paclitaxel was developed to reduce the toxicities associated with solvent-bound paclitaxel (sb-paclitaxel). Areas covered: This review first focuses on the clinical trials evaluating the efficacy and tolerability of nab-paclitaxel in NSCLC at different settings. Read More

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http://dx.doi.org/10.1080/14656566.2018.1546290DOI Listing
January 2019
4 Reads