29,279 results match your criteria Toxicity Terpene


Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Trastuzumab Followed by 5-Fluorouracil/Epirubicin/Cyclophosphamide for HER2-positive Operable Breast Cancer: A Multicenter Phase II Trial.

Anticancer Res 2019 Apr;39(4):2053-2059

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Aim: This study was conducted in order to evaluate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus trastuzumab followed by 5-fluorouracil/ epirubicin/cyclophosphamide (FEC) in a neoadjuvant chemotherapy (NAC) setting for patients with human epidermal growth factor receptor 2 (HER2)-positive operable breast cancer.

Patients And Methods: Each patient received four cycles of 260 mg/m nab-paclitaxel with 6 mg/kg trastuzumab (8 mg/kg as the loading dose) every 3 weeks (q3w) followed by four cycles of FEC (500/100/500 mg/m) q3w. The primary endpoint was pathological complete response (pCR) rate. Read More

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http://dx.doi.org/10.21873/anticanres.13316DOI Listing

Flavanone-3-Hydroxylase Plays an Important Role in the Biosynthesis of Spruce Phenolic Defenses Against Bark Beetles and Their Fungal Associates.

Front Plant Sci 2019 25;10:208. Epub 2019 Feb 25.

Department of Biochemistry, Max Planck Institute for Chemical Ecology, Jena, Germany.

Conifer forests worldwide are becoming increasingly vulnerable to attacks by bark beetles and their fungal associates due to the effects of global warming. Attack by the bark beetle and the blue-stain fungus it vectors () on Norway spruce () is well known to induce increased production of terpene oleoresin and polyphenolic compounds. However, it is not clear whether specific compounds are important in resisting attack. Read More

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http://dx.doi.org/10.3389/fpls.2019.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397876PMC
February 2019
1 Read

Phytochemical Screening and Toxicological Study of Linn Roots: Histopathological and Biochemical Evidence.

J Toxicol 2019 3;2019:8203832. Epub 2019 Feb 3.

Laboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, 19 rue Tarik Ibn Ziad, Casablanca, Morocco.

(A) is a wild species of Aristolochiaceae family; its roots are used by Moroccan people against cancer for many years ago. The objective of the study was to investigate the phytochemical screening, acute and subacute toxicity of roots growing in the north of Morocco. Qualitative and quantitative analyses of roots were performed using standard methods; the acute toxicity of the root extract of the studied plant was assessed in mice by gavage of single doses of 1, 2, and 4 g/kg body weight for 14 days; by the time the subacute toxicity was done using repeated doses 1, 1. Read More

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http://dx.doi.org/10.1155/2019/8203832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377958PMC
February 2019
1 Read

Promoting cannabis products to pharmaceutical drugs.

Eur J Pharm Sci 2019 Apr 7;132:118-120. Epub 2019 Mar 7.

Institute of Plant Science, Agriculture Research Organization, Volcani Center, Rishon LeZion 7528809, Israel.

Cannabis sativa is widely used for medical purposes. However, to date, aroma, popular strain name or the content of two phytocannabinoids-Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are mostly considered for therapeutic activity. This is despite the hundreds of compounds in this plant and their potential synergistic interactions in mixtures. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.027DOI Listing
April 2019
6 Reads

Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

J Toxicol Sci 2019 ;44(3):167-175

Department of Pharmacy, the First Hospital of Jilin University, China.

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered AS IV for 7 days. Histopathological and biochemical analysis were used to assess liver and kidney function. Read More

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http://dx.doi.org/10.2131/jts.44.167DOI Listing
March 2019
2 Reads

Solvent-based paclitaxel or nab-paclitaxel for heavily treated relapsed/refractory small cell lung cancer: Retrospective single-institution observational study.

Medicine (Baltimore) 2019 Mar;98(9):e14758

Departments of Medical Oncology.

Treatment options for patients with relapsed/refractory small cell lung cancer (R/R SCLC) are limited, and the efficacy of salvage therapies for heavily treated patients should be assessed. Here, we evaluated the efficacy of paclitaxel (PTX) in R/R SCLC patients.A single-institute retrospective chart review was conducted. Read More

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http://dx.doi.org/10.1097/MD.0000000000014758DOI Listing

Evaluation of toxicity of clothianidin (neonicotinoid) and chlorfenapyr (pyrrole) insecticides and cross-resistance to other public health insecticides in Anopheles arabiensis from Ethiopia.

Malar J 2019 Feb 22;18(1):49. Epub 2019 Feb 22.

Entomology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329-4027, USA.

Background: Insecticide-based interventions play an integral role in malaria vector control. However, the continued spread of insecticide resistance threatens to undermine progress made thus far and may ultimately lead to operational failure of current control measures. Clothianidin and chlorfenapyr both have unique modes of action and have expanded the number of insecticide classes available to vector control programmes. Read More

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http://dx.doi.org/10.1186/s12936-019-2685-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387473PMC
February 2019
1 Read

Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms.

Biomed Pharmacother 2019 Apr 16;112:108582. Epub 2019 Feb 16.

Department of Antibiotics, Federal University of Pernambuco, Cidade Universitária, Av. Arthur de Sá, S/N, 50670-901, Recife, PE, Brazil. Electronic address:

Objective: Avicennia schaueriana Stapf is an endemic mangrove species widely used by traditional Brazilian communities as a folk remedy for the treatment of rheumatism, ulcers, and skin wounds. The aim of the present study was to evaluate the gastroprotective potential of the ethyl acetate extract from the leaves of A. schaueriana (As-AcOEt). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.043DOI Listing
April 2019
1 Read

Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer.

Cochrane Database Syst Rev 2019 02 18;2:CD012873. Epub 2019 Feb 18.

Medical Oncology Department, Concord Repatriation General Hospital, Concord, New South Wales, Australia, 2139.

Background: Anthracyclines and taxanes are chemotherapeutic agents widely used in a sequential regimen in the adjuvant and neoadjuvant treatment of early breast cancer to reduce the risk of cancer recurrence. Standard practice is to administer anthracycline-based chemotherapy followed by a taxane. Anthracyclines tend to be administered first as they were established before taxanes for treatment of early breast cancer. Read More

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http://dx.doi.org/10.1002/14651858.CD012873.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378927PMC
February 2019
8 Reads

The antagonistic effect of Se on the Pb-weakening formation of neutrophil extracellular traps in chicken neutrophils.

Ecotoxicol Environ Saf 2019 May 14;173:225-234. Epub 2019 Feb 14.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Neutrophils represent an important part of the body's innate immunity and can resist the invasion of pathogenic microorganisms by releasing neutrophil extracellular traps (NETs). In this study, we investigated the toxic effects of lead (Pb) on the release of NETs, the antagonism of selenium (Se) on Pb toxicity and the potential molecular mechanisms. Our model was an in vitro exposure model for the addition of Se, Pb or both in the culture medium and was based on the separation of neutrophils from the peripheral blood of healthy chickens. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.033DOI Listing
May 2019
1 Read

Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study.

Life Sci 2019 Mar 14;221:311-318. Epub 2019 Feb 14.

Department of Pharmacology and Psychopharmacology Research Unit, Marmara University School of Pharmacy, Istanbul, Turkey.

Aims: The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated.

Material And Methods: The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.018DOI Listing
March 2019
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The role of chloroplasts in the oxidative stress that is induced by zearalenone in wheat plants - The functions of 24-epibrassinolide and selenium in the protective mechanisms.

Plant Physiol Biochem 2019 Apr 1;137:84-92. Epub 2019 Feb 1.

Polish Academy of Sciences, The Franciszek Górski Institute of Plant Physiology, Niezapominajek 21, 30-239, Kraków, Poland. Electronic address:

This study focused on the idea that the toxic effect of zearalenone (ZEA) and the protective actions of the brassinosteroid - 24-epibrassinolide (EBR) as well as selenium are dependent on its accumulation in chloroplasts to a high degree. These organelles were isolated from the leaves of oxidative stress-sensitive and stress-tolerant wheat cultivars that had been grown from grains that had been incubated in a solution of ZEA (30 μM), NaSeO (Se, 10 μM), EBR (0.1 μM) or in a mixture of ZEA with Se or EBR. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.01.030DOI Listing
April 2019
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Environmentally relevant concentrations of bifenthrin affect the expression of estrogen and glucocorticoid receptors in brains of female western mosquitofish.

Aquat Toxicol 2019 Apr 17;209:121-131. Epub 2018 Dec 17.

Department of Neurobiology, Physiology, and Behavior, University of California, Davis, United States.

In recent decades, pyrethroid pesticides have been deemed a safer alternative to previously used pesticides. While some evidence supports this assumption in mammals and birds, exposure to certain pyrethroids can affect concentrations of hormones vital to reproduction in fish. Thus, we hypothesized that pyrethroid exposure impacts fish reproductive behavior and the expression of genes associated with reproduction. Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.12.001DOI Listing
April 2019
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Metabolism of nivalenol and nivalenol-3-glucoside in rats.

Toxicol Lett 2019 May 12;306:43-52. Epub 2019 Feb 12.

Christian Doppler Laboratory for Mycotoxin Metabolism, Center for Analytical Chemistry, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad Lorenz Str. 20, Tulln 3430, Austria.

Plant-derived mycotoxin conjugates like deoxynivalenol-3-glucoside can be partly hydrolyzed to their aglycones in vivo, albeit to different extent depending on the mycotoxin conjugate and on the animal species. The aim of this work was to investigate the metabolization of the trichothecene mycotoxin nivalenol (NIV) and the fate of its modified form NIV-3-glucoside (NIV3G) in rats. To that end, 350 μg/kg body weight of NIV and the equimolar dose of NIV3G were administered to six rats by gavage in a 5 × 6 design and excreta were collected for 2 days after each treatment. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.02.006DOI Listing
May 2019
10 Reads

Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera.

Pestic Biochem Physiol 2019 Feb 21;154:46-59. Epub 2018 Dec 21.

Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China. Electronic address:

When any living organism is frequently exposed to any drugs or toxic substances, they evolve different detoxification mechanism to confront with toxicants during absorption and metabolism. Likewise, the insects have evolved detoxification mechanisms as they are frequently exposed to different toxic secondary plant metabolites and commercial insecticides. ABC transporter superfamily is one of the largest and ubiquitous group of proteins which play an important role in phase III of the detoxification process. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.12.007DOI Listing
February 2019
2 Reads
2.014 Impact Factor

Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a.

Life Sci 2019 Mar 11;221:152-158. Epub 2019 Feb 11.

Department of Ophthalmology, Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China. Electronic address:

Aims: The therapeutic strategies for diabetic retinopathy (DR) are disappointing. Ginsenoside Rg1 (Rg1) extracted from Panax ginseng can induce glucose uptake and lower oxidative stress. We aimed to explore the effect of Rg1 on DR using human retinal pigment epithelium cells (ARPE-19). Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.021DOI Listing
March 2019
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Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans.

PLoS Genet 2019 02 14;15(2):e1007975. Epub 2019 Feb 14.

Department of Genetics, Harvard Medical School, Boston, MA, United States of America.

Chemicals that are highly prevalent in our environment, such as phthalates and pesticides, have been linked to problems associated with reproductive health. However, rapid assessment of their impact on reproductive health and understanding how they cause such deleterious effects, remain challenging due to their fast-growing numbers and the limitations of various current toxicity assessment model systems. Here, we performed a high-throughput screen in C. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375566PMC
February 2019
1 Read

The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair.

PLoS Genet 2019 02 14;15(2):e1007971. Epub 2019 Feb 14.

Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392337PMC
February 2019

The protective effects of melatonin on oxidative damage and the immune system of the Chinese mitten crab (Eriocheir sinensis) exposed to deltamethrin.

Sci Total Environ 2019 Feb 6;653:1426-1434. Epub 2018 Nov 6.

National Demonstration Center for Experimental Fisheries Science Education, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai, China. Electronic address:

Deltamethrin (Del), an important broad-spectrum insecticide, is widely used in agricultural activities. However, Del is an effective reactive oxygen species (ROS) inducer that induces oxidative stress damage in cells or tissues. Del is significantly more toxic to aquatic organisms, especially crustaceans, than to mammals and birds. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.063DOI Listing
February 2019
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Encapsulation of inuloxin A, a plant germacrane sesquiterpene with potential herbicidal activity, in β-cyclodextrins.

Org Biomol Chem 2019 02;17(9):2508-2515

Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy.

Inuloxin A is a promising plant phytotoxic sesquiterpene that deserves further studies to evaluate its potential as a bioherbicide. However, its low solubility in water and its bioavailability could hamper its practical applications. For this reason, inuloxin A was complexed with β-cyclodextrins by using three different methods, i. Read More

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http://dx.doi.org/10.1039/c8ob03156hDOI Listing
February 2019

Immunosuppressive effects of the limonoid azadirachtin, insights on a nongenotoxic stress botanical, in flesh flies.

Pestic Biochem Physiol 2019 Jan 4;153:55-66. Epub 2018 Nov 4.

Department of Entomology, Faculty of Science, Cairo University, Giza, PO Box 12613, Egypt. Electronic address:

The tetranortriterpenoid azadirachtin (Aza) is a well-known insect growth disruptor of plant origin. Although its actions on insects have been extensively studied; fragmentary reports are available from the immunological point of view. Therefore, in the present study, total (THC) and differential hemocyte counts (DHC), nodulation, phenoloxidase (PO) activity, immune-reactive lysozymes and inducible nitric oxide (NO) were assessed, as measures of immune responses, in Sarcophaga argyrostoma 3 instars challenged individually with M. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.11.004DOI Listing
January 2019
1 Read

LC of lambda-cyhalothrin stimulates reproduction on the moth Mythimna separata (Walker).

Pestic Biochem Physiol 2019 Jan 3;153:47-54. Epub 2018 Nov 3.

Key Laboratory of Economic and Applied Entomology of Liaoning Province, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:

Lambda-cyhalothrin has long been recommended as an effective insecticide to control the oriental armyworm, Mythimna separata (Walker), a notorious migratory pest of agricultural plants. Previous researches have suggested that survival, development, and reproduction of insects are influenced by sublethal concentrations of insecticides. However, the effects of sublethal concentrations of lambda-cyhalothrin on M. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00483575183043
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http://dx.doi.org/10.1016/j.pestbp.2018.11.001DOI Listing
January 2019
7 Reads

Insecticide activity of Curcuma longa (leaves) essential oil and its major compound α-phellandrene against Lucilia cuprina larvae (Diptera: Calliphoridae): Histological and ultrastructural biomarkers assessment.

Pestic Biochem Physiol 2019 Jan 12;153:17-27. Epub 2018 Oct 12.

Laboratory of Parasitic Diseases, Federal University of Parana, Curitiba, Brazil.

Lucilia cuprina, known as the Australian blowfly, is of high medico-sanitary and veterinary importance due to its ability to induce myiasis. Synthetic products are the most frequent form of fly control, but their indiscriminate use has selected for resistant populations and accounted for high levels of residues in animal products. This study aimed to assess the effect of essential oil from leaves of Curcuma longa (CLLEO), and its major compound α-phellandrene against L. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.10.002DOI Listing
January 2019
3 Reads

Isolation, characterization and mode of action of a larvicidal compound, 22-hydroxyhopane from Adiantum latifolium Lam. against Oryctes rhinoceros Linn.

Pestic Biochem Physiol 2019 Jan 8;153:161-170. Epub 2018 Dec 8.

Department of Zoology, University College, Thiruvananthapuram, Kerala 695034, India. Electronic address:

Oryctes rhinoceros Linn. is one of the most serious pests of coconuts and other palms. Following bioassay guided method, a larvicidal compound, 22-hydroxyhopane has been isolated for the first time from methanol extract of leaves of Adiantum latifolium Lam. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.11.018DOI Listing
January 2019
1 Read
2.014 Impact Factor

The insecticidal activity of Satureja hortensis essential oil and its active ingredient -carvacrol against Acrobasis advenella (Zinck.) (Lepidoptera, Pyralidae).

Pestic Biochem Physiol 2019 Jan 17;153:122-128. Epub 2018 Nov 17.

Siedlce University of Natural Sciences and Humanities, Faculty of Natural Sciences, Department of Biochemistry and Molecular Biology, Prusa 12, 08-110 Siedlce, Poland.

Nowadays, Acrobasis advenella is considered a pest of the highest economic significance in black chokeberry plantations, negatively affecting the quantity and quality of fruits. The aim of this study was to investigate the effect of Satureja hortensis essential oil and its main constituent, carvacrol, on the life cycle and physiology of A. advenella. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.11.010DOI Listing
January 2019
1 Read

Cypermethrin-based formulation Barrage induces histological changes in gills of the Pantanal endemic shrimp Macrobrachium pantanalense.

Environ Toxicol Pharmacol 2019 Apr 30;67:66-72. Epub 2019 Jan 30.

Programa de Pós-Graduação em Zootecnia, Universidade Estadual de Mato Grosso do Sul, Unidade Universitária de Aquidauana, Rodovia Aquidauana-UEMS Km 12, Cx Postal 25- CEP, 79200-000, Aquidauana, MS, Brazil.

Pantanal shrimp Macrobrachium pantanalense was exposed for 96 h to the cypermethrin-based formulation Barrage. Population-relevant endpoints (survival, swimming behavior) as well as histopathology of gills were analyzed. A 96 h-LC of 0. Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.014DOI Listing
April 2019
1 Read

Cypermethrin induction of DNA damage and oxidative stress in zebrafish gill cells.

Ecotoxicol Environ Saf 2019 May 8;173:1-7. Epub 2019 Feb 8.

Laboratorio de Microscopia Aplicada a Estudios Moleculares y Celulares, Facultad de Ingeniería, Universidad Nacional de Entre Ríos (UNER), Ruta 11 km 10, Oro Verde,3101, Entre Ríos, Argentina; IBB-CONICET-UNER, Argentina. Electronic address:

Cypermethrin (CYP) is a synthetic pyrethroid insecticide, used to control pests in domestic, industrial and agricultural environments. According to recent reports, it is one of the most common contaminants in freshwater aquatic systems. The aim of this study was to evaluate its potential genotoxic effect and the activation of the superoxide dismutase (SOD) and catalase (CAT) systems of adult zebrafish gill cells after in vivo exposure. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.004DOI Listing

An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.

Eur J Med Chem 2019 Mar 1;166:400-416. Epub 2019 Feb 1.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100, Shaanxi, People's Republic of China. Electronic address:

Grayanane diterpenoids, possessing a unique 5/7/6/5 tetracyclic system, exist exclusively in plants of the Ericaceae family. Owing to their various skeletons, complex structures, and diverse bioactivities, grayanoids have been the topic of research in many phytochemical and pharmacological laboratories, offering opportunities for the development of new drugs with analgesic, anti-inflammatory, and protein tyrosine phosphatase 1B (PTP1B) properties. Recently, a number of new grayanane diterpenoids with unprecedented carbon skeletons have been obtained from plants of the Ericaceae family, and they exhibit diverse biological properties, such as agalgesic, antinociceptive, anticancer, antiviral, antifeedant, insecticidal, toxicity, and PTP1B. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.079DOI Listing
March 2019
1 Read

Towards green drugs against cestodes: Effectiveness of Pelargonium roseum and Ferula gummosa essential oils and their main component on Echinococcus granulosus protoscoleces.

Vet Parasitol 2019 Feb 17;266:84-87. Epub 2019 Jan 17.

School of Pharmacy, University of Camerino, Camerino, Italy.

Cystic echinococcosis is of great public health importance. Surgery is the efficient treatment for this infection. To minimize the risk of cyst intraoperative leakage, using scolicidals is crucial. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.019DOI Listing
February 2019
3 Reads

Class III β-tubulin Expression in Colorectal Neoplasms Is a Potential Predictive Biomarker for Paclitaxel Response.

Anticancer Res 2019 Feb;39(2):655-662

Hacettepe University Transgenic Animal Technologies Research and Application Center, Ankara, Turkey

Background/aim: The challenges of cololorectal cancer (CRC) management include prediction of outcome and drug response or chemoresistance. This study aimed at examining whether βIII-tubulin (TUBB3), present in various types of normal tissues and cancer, is a biomarker for the response of colorectal neoplasms to paclitaxel.

Materials And Methods: Six tissue microarrays (TMAs) including 14 colon mucosa, 78 polyps and 202 CRCs were constructed. Read More

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http://dx.doi.org/10.21873/anticanres.13160DOI Listing
February 2019
1 Read

Critical time window of fenvalerate-induced fetal intrauterine growth restriction in mice.

Ecotoxicol Environ Saf 2019 May 30;172:186-193. Epub 2019 Jan 30.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui, China. Electronic address:

Fenvalerate (FEN), a representative type II pyrethroid, is a widely used pyrethroid insecticide and a potential environmental contaminant. Several studies demonstrated that gestational FEN exposure induced intrauterine growth restriction (IUGR). However, the critical time window of FEN-induced fetal IUGR remains obscure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193006
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http://dx.doi.org/10.1016/j.ecoenv.2019.01.054DOI Listing
May 2019
7 Reads
2.762 Impact Factor

Toxic Effects and Possible Mechanisms of Deoxynivalenol Exposure on Sperm and Testicular Damage in BALB/c Mice.

J Agric Food Chem 2019 Feb 15;67(8):2289-2295. Epub 2019 Feb 15.

Institute for Agri-Food Standards and Testing Technology , Shanghai Academy of Agricultural Sciences , Shanghai , 201403 , People's Republic of China.

Deoxynivalenol (DON, vomitoxin) is the most common mycotoxin in cereals and grains. DON contamination can cause a serious health threat to humans and farm animals. DON has been reported to exert significant toxicity effects on the male reproductive system. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b04783DOI Listing
February 2019
3 Reads

Toxicity, mode of action, and synergist potential of flonicamid against mosquitoes.

Pestic Biochem Physiol 2018 Oct 15;151:3-9. Epub 2018 Jun 15.

Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, Gainesville, FL 32610, USA. Electronic address:

The present study focused on the toxicity of the aphid anti-feedant flonicamid and its main metabolite, 4-trifluoromethylnicotinamide (TFNA-AM) to Aedes aegypti and Anopheles gambiae mosquitoes. The compounds were toxic to both species via topical application, resulting in un-coordinated locomotion and leg splaying, with a favorable An. gambiae LD value of 35 ng/mg for TFNA-AM, but no significant lethality to Ae. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.06.004DOI Listing
October 2018
2 Reads

Proteasome inhibition by MG-132 protects against deltamethrin-induced apoptosis in rat hippocampus.

Life Sci 2019 Mar 26;220:76-83. Epub 2019 Jan 26.

Department of Toxicology, MOE Key Laboratory of Environmental and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

Aims: Deltamethrin (DM), a type II synthetic pyrethroid insecticide, is widely used in agriculture and home pest control. The evaluation of their toxic effects is of major concern to public health. However, the molecular mechanism of DM-induced neurodegenerative disease is still far from clear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.041DOI Listing
March 2019
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Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway.

Toxicol Lett 2019 May 25;305:19-31. Epub 2019 Jan 25.

College of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control/National Engineering Research Center for Breeding Swine Industry, Guangzhou 510642, China. Electronic address:

The intake of food containing deoxynivalenol frequently causes damage to the intestine, the renewal of which is driven by intestinal stem cells (ISCs). Nevertheless, the toxicity of deoxynivalenol on ISCs and its underlying mechanisms remain to be elucidated. As pigs are the most sensitive animals to deoxynivalenol, we used piglets for investigation in this study. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.01.008DOI Listing
May 2019
3 Reads

Gossypol Induces Disruption of Spermatogenesis and Steroidogenesis in Male Mice.

J Agric Food Chem 2019 Feb 8;67(7):2075-2085. Epub 2019 Feb 8.

Department of Biotechnology , Korea University , Seoul , 02841 , Republic of Korea.

Gossypol, commonly found in cotton seeds, is hazardous to male reproductive physiology. Although several studies have indicated the toxicity of gossypol in human and animal reproduction, the mechanism of gossypol action in testes has not yet been elucidated. In the present study, we investigated the effects of gossypol in normal mouse testis cells, TM3 and TM4 cells, and in gossypol-treated C57BL/6 mice. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06946DOI Listing
February 2019
2 Reads

Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba.

Sci Total Environ 2019 Mar 2;657:926-937. Epub 2018 Dec 2.

Department of Biology, Aveiro University, Campus de Santiago, 3810-193 Aveiro, Portugal; Centre for Environmental and Marine Studies (CESAM), Campus de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In the last years the environmental presence of pharmaceuticals has gained increasing attention. Research data show that these compounds can cause toxicological effects in different species of fish, mollusks and macroinvertebrates. However, the literature is scarce in terms of ecotoxicity data especially focusing on plants as test organisms. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.002DOI Listing
March 2019
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Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance.

Authors:
David O Kennedy

Sports Med 2019 Feb;49(Suppl 1):39-58

Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK.

Subjective alertness and optimal cognitive function, including in terms of attention, spatial/working memory and executive function, are intrinsic to peak performance in many sports. Consumption of a number of plant-derived 'secondary metabolite' phytochemicals can modulate these psychological parameters, although there is a paucity of evidence collected in a sporting context. The structural groups into which these phytochemicals fall-phenolics, terpenes and alkaloids-vary in terms of the ecological roles they play for the plant, their toxicity and the extent to which they exert direct effects on brain function. Read More

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http://dx.doi.org/10.1007/s40279-018-1007-0DOI Listing
February 2019
4 Reads

Physiological and biochemical responses of Microcystis aeruginosa to phosphine.

Environ Pollut 2019 Apr 9;247:165-171. Epub 2019 Jan 9.

School of Environment and Energy, South China University of Technology, Guangzhou, 510006, China.

The frequent outbreaks of cyanobacteria bloom are often accompanied by the generation and release of reduced phosphorus species (e.g., phosphine), which raises interesting questions regarding their potential algae-related effects. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.12.086DOI Listing
April 2019
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Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin.

Int J Nanomedicine 2019 11;14:557-571. Epub 2019 Jan 11.

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China,

Purpose: Rebaudioside A (RA) has nanocarrier characteristics that allow it to self-assemble into micelles in aqueous solutions. The purpose of this study was to determine if a self-nanomicellizing solid dispersion based on RA could be utilized as an oral nano-drug delivery system.

Materials And Methods: Curcumin (Cur) served as a model hydrophobic drug, and a Cur-loaded self-nanomicellizing solid dispersion based on RA (RA-Cur) was formulated. Read More

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https://www.dovepress.com/novel-self-nanomicellizing-solid-d
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http://dx.doi.org/10.2147/IJN.S191337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333391PMC
February 2019
25 Reads

Chemical profiling, cytotoxicity and phytotoxicity of foliar volatiles of Hyptis suaveolens.

Ecotoxicol Environ Saf 2019 Apr 18;171:863-870. Epub 2019 Jan 18.

Department of Botany, Panjab University, Chandigarh 160014, India; Central University of Punjab, Mansa Road, Bathinda 151001, India.

In the present study, the essential oil (EO) of Hyptis suaveolens has been explored for the first time for its phytotoxic and cytotoxic activities. The phytotoxic activity was assessed against rice (Oryza sativa) and its major troublesome weed, Echinochloa crus-galli, under laboratory and screenhouse conditions. GC-MS analysis revealed EO to be monoterpenoid (~ 79% monoterpenes) in nature with α-phellandrene (22. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.091DOI Listing
April 2019
2 Reads

Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community.

Ecotoxicol Environ Saf 2019 Apr 18;171:854-862. Epub 2019 Jan 18.

University of Agricultural Science and Veterinary Medicine "Ion Ionescu de la Brad", Department of Molecular Biology, Histology and Embriology, Faculty of Veterinary Medicine, 8, Mihail Sadoveanu Alley, 700489 Iasi, Romania.

In this study zebrafish specimens were exposed for 15 days to 0.25, 0.5, 1 and 2 μg L non-lethal concentrations of deltamethrin (DM) knowing that is the active compound in insecticides used on agricultural crops. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.057DOI Listing
April 2019
3 Reads

Chemical characterization of liposomes containing nutraceutical compounds: Tyrosol, hydroxytyrosol and oleuropein.

Biophys Chem 2019 03 14;246:25-34. Epub 2019 Jan 14.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; Centre for Colloid and Surface Science (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy; Operative Unit, University of Siena, CampoVerde, Calabria, Italy.

Tyrosol, hydroxytyrosol and oleuropein are among the major phenolic compounds in fruits, leaves and oils from Olea europaea L. These natural antioxidants molecules revealed several beneficial effects on human health, but a low bioavailability and accessibility to targeted site. Liposomes are drug/nutraceutical delivery carriers, used for driving bioactive molecules to desired target tissues, decreasing potential side effects and protecting the encapsulated molecule from enzymatic metabolic processes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014622183036
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http://dx.doi.org/10.1016/j.bpc.2019.01.002DOI Listing
March 2019
16 Reads

Chemical control of polyphagous pests on their auxiliary hosts can minimize insecticide resistance: A case study of Spodoptera exigua Hübner (Lepidoptera: Noctuidae) in cotton agroecosystem.

Ecotoxicol Environ Saf 2019 Apr 16;171:721-727. Epub 2019 Jan 16.

Department of Entomology, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Multan, Pakistan.

Use of insecticides for agricultural pest management have significant environmental impacts. Using integrated approaches to minimize the frequency of insecticide application by incorporating cultural control tactics can keep environmental hazards to the minimum. The alternate hosts of polyphagous pests have significant role in population development and success of chemical control. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.038DOI Listing
April 2019
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Ecological risk assessment of alpha-cypermethrin-treated food ingestion and reproductive toxicity in reptiles.

Ecotoxicol Environ Saf 2019 Apr 15;171:657-664. Epub 2019 Jan 15.

Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China. Electronic address:

Pesticides are proposed as one of the many causes for the global decline in reptile population. To understand the potential impact of alpha-cypermethrin (ACP) in reptiles, in the current study, we used a tri-trophic food web (plants - herbivores - natural enemies of predators) to examine the reproductive toxicity and biomarker changes. Based on the Maximum Residue Limit (MRL) of ACP in several agricultural products, we designed three concentrations 0, 2 (MRL), and 20 mg/kg as three treatment groups for this research. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193001
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http://dx.doi.org/10.1016/j.ecoenv.2019.01.012DOI Listing
April 2019
16 Reads
2.762 Impact Factor

New Perspectives on the Efficacy of Gallic Acid in Cosmetics & Nanocosmeceuticals.

Curr Pharm Des 2018 ;24(43):5181-5187

College of Pharmacy, Manchester University, Fort Wayne, IN 46845, United States.

Background: Gallic acid (GA-3,4,5-trihydroxybenzoic acid), a phenolic phytochemical, is a ubiquitous secondary metabolite found in most plants, with appreciable concentrations in grapes seed, rose flowers, sumac, oak and witch hazel. GA often results from the hydrolysis of terpenes and the polyphenol tannic acid.

Applications: It exhibits powerful antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. Read More

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http://dx.doi.org/10.2174/1381612825666190118150614DOI Listing
January 2018
10 Reads

Sublethal insecticide exposure of an herbivore alters the response of its predator.

Environ Pollut 2019 Apr 7;247:39-45. Epub 2019 Jan 7.

Department of Chemical Ecology, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany. Electronic address:

Sublethal insecticide exposure poses risks for many non-target organisms and is a challenge for successful implementation of integrated pest management (IPM) programs. Next to detrimental effects of short-term insecticide exposure on fitness-related traits of organisms, also properties such as chemical signaling traits can be altered, which mediate intra- and interspecific communication. We investigated the effects of different durations of larval sublethal exposure to the pyrethroid lambda-cyhalothrin on performance traits of larvae and adults of the herbivorous mustard leaf beetle, Phaedon cochleariae. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.12.040DOI Listing
April 2019
1 Read

Effect of nutritional state and dispersal on the reproductive efficiency in Triatoma infestans (Klug, 1834) (Hemiptera: Reduviidae: Triatominae) susceptible and resistant to deltamethrin.

Acta Trop 2019 Mar 14;191:228-238. Epub 2019 Jan 14.

Laboratorio de Investigación en Triatominos (LIT), Centro de Referencia de Vectores (CeReVe)-Programa Nacional de Chagas-Ministerio de Salud de la Nación, Santa María de Punilla, Córdoba, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

The dispersal of insects is determinant in the colonization of new areas and the propagation of insecticide resistance. Nutritional status and reproductive characteristics determine the colonization capacity after the dispersal event. Studies about of the effects of dispersal on reproduction in triatomines are few and none in resistant insects. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.012DOI Listing
March 2019
2 Reads

Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study.

Cell Mol Biol Lett 2019 10;24. Epub 2019 Jan 10.

2School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Cancer Hospital of Yunnan Province, Kunming Medical University, NO.1168, West Chunrong Road, Chenggong Developing Area, Kunming, 650031 China.

Objective: To investigate the anti-tumor effects and the mechanism of the compound 13-chlorine-3, 15-dioxy-gibberellic acid methyl ester (GA-13315) in lung adenocarcinoma in vitro and in vivo.

Methods: The antiproliferative effect of GA-13313 on the A549 cell line was determined by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide) assay. A xenograft model of A549 was established to evaluate the anti-tumor effect and histopathological examination was performed to assess the toxicity of GA-13315. Read More

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http://dx.doi.org/10.1186/s11658-018-0126-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327519PMC
April 2019
3 Reads

Triterpenes from the Mushroom : Isolation, Structure Determination and Investigation in Bdelloid Rotifer Assays.

Molecules 2019 Jan 15;24(2). Epub 2019 Jan 15.

Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.

Twelve compounds (⁻) were isolated from the methanol extract of brick cap mushroom ( (Schaeff.) P. Kumm. Read More

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http://dx.doi.org/10.3390/molecules24020301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359218PMC
January 2019
3 Reads