1,618 results match your criteria Toxicity Selective Serotonin Reuptake Inhibitor


Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor.

Eur J Pharmacol 2019 Mar 19;853:129-135. Epub 2019 Mar 19.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji 670-8524, Japan. Electronic address:

The selective serotonin reuptake inhibitors (SSRIs) fluvoxamine and sertraline show a high affinity for sigma-1 receptors. Fluvoxamine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells via a sigma-1 receptor-mediated mechanism, which suggests that neurogenesis may be involved in the antidepressant action of fluvoxamine. However, the effects of sertraline on neurite outgrowth remain unclear. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.032DOI Listing
March 2019
1 Read

A fluvoxamine-related fatality: Case report with postmortem concentrations.

Forensic Sci Int 2019 Mar 1. Epub 2019 Mar 1.

University of California San Diego, USA; University of California San Francisco, USA. Electronic address:

Fluvoxamine is a selective serotonin reuptake inhibitor that has been considered relatively safe in overdose. At therapeutic and supratherapeutic concentrations, fluvoxamine affects cardiac conduction, prolongs QTc interval, causes hypotension, obtundation, and can increase propensity for seizures. A man in his 60s was found dead at his home with a postmortem fluvoxamine peripheral blood concentration of 4. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.02.047DOI Listing
March 2019
2 Reads
2.115 Impact Factor

Waterborne pharmaceutical uptake and toxicity is modified by pH and dissolved organic carbon in zebrafish.

Aquat Toxicol 2019 May 14;210:11-18. Epub 2019 Feb 14.

Department of Biology, McMaster University, 1280 Main St. W., Hamilton, L8S 4K1, ON, Canada.

Human and veterinary pharmaceuticals have been observed in natural aquatic environments around the world, and many have been shown to impact fish health. Presently, we examined the influence of pH, dissolved organic carbon (DOC) and Na or Ca on the bioavailability and toxicity of waterborne pharmaceuticals in larval zebrafish. Drugs included sertraline (selective serotonin reuptake inhibitor; SSRI), fluoxetine (SSRI), diclofenac (nonsteroidal anti-inflammatory drug) and ethinyl estradiol (estrogen; EE). Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.008DOI Listing
May 2019
2 Reads

Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour.

Sci Total Environ 2019 May 6;664:915-926. Epub 2019 Feb 6.

Institute of Environment, Health and Societies, Brunel University London, Uxbridge, Middlesex, UB8 3PH, United Kingdom.

There is concern that psychoactive drugs present in the aquatic environment could affect the behaviour of fish, and other organisms, adversely. There is considerable experimental support for this concern, although the literature is not consistent. To investigate why, fish were exposed to three concentrations of the synthetic opiate tramadol for 23-24 days, and their anxiolytic behaviour in a novel tank diving test was assessed both before and after exposure. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.090DOI Listing
May 2019
4 Reads
4.099 Impact Factor

Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.

Pharmacology 2019 29;103(3-4):189-201. Epub 2019 Jan 29.

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Japan,

Background: A report examining whether clinically available antidepressants increase urethral smooth muscle contraction via antagonistic effects on the α2-adrenoceptor (α2-AR) is lacking.

Objectives: The present study was performed to evaluate the potential of clinically available antidepressants to reverse α2-AR-mediated contractile inhibition in rat vas deferens, in order to predict whether they can induce voiding impairment.

Method: The effects of 18 antidepressants of different classes on electrical field stimulation (EFS)-induced contractions suppressed by 10-8 mol/L clonidine (a selective α2-AR agonist) in isolated rat vas deferens were investigated and related to their respective clinical blood concentrations. Read More

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http://dx.doi.org/10.1159/000495616DOI Listing
March 2019
1 Read

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies.

AAPS PharmSciTech 2019 Jan 2;20(1):22. Epub 2019 Jan 2.

Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Sinhgad Technical Education Society, Narhe, Pune, MS, 411041, India.

Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n. Read More

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http://dx.doi.org/10.1208/s12249-018-1213-yDOI Listing
January 2019
10 Reads

The effect of duloxetine on penicillin-induced epileptiform activity in rats.

Neurol Res 2019 Apr 24;41(4):298-305. Epub 2018 Dec 24.

b Department of Physiology, Faculty of Medicine , Tokat Gaziosmanpasa University , Tokat , Turkey.

Aim: Previous studies showed the existence of a relationship between epilepsy and depression. Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) used in the treatment of the major depressive disorder. The aim of the present study was to investigate the effect of duloxetine on penicillin-induced epileptiform activity in an experimental rat model of acute partial epilepsy. Read More

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http://dx.doi.org/10.1080/01616412.2018.1560642DOI Listing
April 2019
4 Reads

Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.

Molecules 2018 Dec 14;23(12). Epub 2018 Dec 14.

Department of Biology, Changhua University of Education, 1 Jin-De Road, Changhua, Taiwan 50007.

Metastasis of hepatocellular carcinoma (HCC) is usually unrecognized before any pathological examination, resulting in time-taking treatment and poor prognosis. As a consequence, HCC patients usually show symptoms of depression. In order to suppress such psychiatric disorders and to facilitate better treatment outcome, antidepressants are prescribed. Read More

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http://dx.doi.org/10.3390/molecules23123327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321194PMC
December 2018
2 Reads

A mechanistic approach to the in-vitro resistance modulating effects of fluoxetine against meticillin resistant Staphylococcus aureus strains.

Microb Pathog 2019 Feb 7;127:335-340. Epub 2018 Dec 7.

School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil. Electronic address:

Emergence of methicilin resistant Staphylococcus aureus (MRSA) strains is a major cause of infirmity worldwide and has limited our therapeutic options against these pathogens. In this regard, the search for candidates with an antimicrobial activity, with a greater efficacy and a lower toxicity, is necessary. As a result, there is greater need to search for resistance modifying agents which, in combination with existing drugs, will restore the efficacy of these drugs. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.11.056DOI Listing
February 2019
1 Read

Transformation products of citalopram: Identification, wastewater analysis and in silico toxicological assessment.

Chemosphere 2019 Feb 5;217:858-868. Epub 2018 Nov 5.

Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisboa, Portugal.

The objective of this study was to identify transformation products (TPs) of citalopram (CIT), an antidepressant drug, in laboratory experiments. Moreover, toxicity predictions and analyzes in wastewater samples were performed. For the formation of TPs, raw water was used for the processes of hydrolysis; photodegradation under ultraviolet (UV) irradiation and chlorination. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.027DOI Listing
February 2019
17 Reads

Aquatic ecotoxicity of an antidepressant, sertraline hydrochloride, on microbial communities.

Sci Total Environ 2019 Mar 12;654:129-134. Epub 2018 Nov 12.

Xinjiang Key Laboratory of Environmental Pollution and Bioremediation, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China; College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

Sertraline hydrochloride (Ser-HCl), a widely used antidepressant, becomes an aquatic contaminant via metabolic excretion and improper disposal; however, it is unknown how Ser-HCl affects aquatic microbial communities. The present study investigated the effects of Ser on the structures of aquatic microbial communities via high-throughput sequencing analyses. Ser-HCl treatment inhibited the growth of two model algae (the green alga, Chlorella vulgaris, and the cyanobacterium, Microcystis aeruginosa) and decreased the chlorophyll a (Chl-a) concentration in the microcosm to reduce the photosynthetic efficiency. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.164DOI Listing
March 2019
2 Reads
4.099 Impact Factor

[Combined effects of fluoxetine and triclosan on Pseudorasbora parva.]

Ying Yong Sheng Tai Xue Bao 2018 Sep;29(9):3058-3066

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.

We examined the effects of binary mixture of two different pharmaceutical and personal care products (PPCPs) on aquatic organisms. The topmouth gudgeon Pseudorasbora parva, native to northeast China, was used to study the combined effects of fluoxetine (FLX) and triclosan (TCS) on its different organs. After acute (4 h) and chronic (42 d) treatments, the combined effects of FLX/TCS on phase I and phase II detoxification enzymes, nervous system, digestive system and antioxidant system were evaluated. Read More

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http://www.cnki.net/kcms/doi/10.13287/j.1001-9332.201809.038
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http://dx.doi.org/10.13287/j.1001-9332.201809.038DOI Listing
September 2018
20 Reads

Accumulation, metabolite and active defence system responses of fluoxetine in zebrafish embryos: Influence of multiwalled carbon nanotubes with different functional groups.

Aquat Toxicol 2018 Dec 30;205:204-212. Epub 2018 Oct 30.

School of Hydraulic and Ecological Engineering, Nanchang Institute of Technology, Nanchang, 330099, China.

Studies on the bioavailability of organic contaminants adsorbed to nanomaterials are increasing. In this study, we investigated the interaction between fluoxetine (FLX) and three multiwalled carbon nanotubes (MWCNTs) with different functional groups in zebrafish (Danio rerio) embryos, focusing on the FLX accumulation, the formation of the metabolite norfluoxetine (NFLX), and the active defence system responses. The accumulation of FLX in zebrafish was intensified by MWCNTs (46-99%), which simultaneously facilitated the formation of the metabolite NFLX by 23-167%. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183085
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http://dx.doi.org/10.1016/j.aquatox.2018.10.018DOI Listing
December 2018
10 Reads

Linezolid-associated serotonin toxicity after escitalopram discontinuation: concomitant drug considerations.

BMJ Case Rep 2018 Oct 30;2018. Epub 2018 Oct 30.

College of Pharmacy, University of Florida, Gainesville, Florida, USA.

We report a case of a hospitalised patient who developed probable serotonin toxicity shortly after the initiation of linezolid in whom the selective serotonin reuptake inhibitor (SSRI) escitalopram had been recently discontinued. On day 2 of linezolid administration, the patient reported severe anxiety and was observed to have full body jerking and twitching motions without mental status change. Notably, the patient was concomitantly receiving the antidepressant, trazodone and the benzodiazepine, clonazepam possibly affecting the severity and manifestations of serotonin toxicity. Read More

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http://dx.doi.org/10.1136/bcr-2018-226597DOI Listing
October 2018
5 Reads

Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague-Dawley rats.

Regul Toxicol Pharmacol 2018 Dec 23;100:45-51. Epub 2018 Oct 23.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) have developed as novel antidepressants and have been determined to possess higher efficacy and less adverse effects compared to other antidepressants. Our previous studies have showed that LPM570065, a new potent TRI, is relatively nontoxic in acute, subchronic toxicity and genotoxicity evaluations. In the current study, toxicity of LPM570065 was further evaluated on the fertility and early embryonic development in Sprague-Dawley rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02732300183027
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http://dx.doi.org/10.1016/j.yrtph.2018.10.008DOI Listing
December 2018
14 Reads

The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats.

Pharmacol Rep 2018 Dec 21;70(6):1173-1179. Epub 2018 Jul 21.

Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil. Electronic address:

Background: The use of antidepressants in combination is common practice following non-response to single antidepressant agents. Nevertheless, the scientific literature lacks preclinical studies regarding the combined administration of antidepressants across multiple behavioral measures including, but not limited to, cognition. Hence, we aimed to determine the effects of paroxetine (PAR), venlafaxine (VEN) and bupropion (BUP) alone or combined (PAR+BUP or VEN+BUP) on spatial and affective memory tasks to advance the knowledge about the combined use of antidepressants in cognition. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.07.003DOI Listing
December 2018
5 Reads

Demystifying serotonin syndrome (or ).

Can Fam Physician 2018 Oct;64(10):720-727

Assistant Professor and Acting Director of the Doctor of Pharmacy program at the Leslie Dan Faculty of Pharmacy at the University of Toronto in Ontario, an advanced practice hospital pharmacist at the Centre for Addiction and Mental Health in Toronto, a doctoral candidate in the School of Health Professions Education at Maastricht University in the Netherlands, and a research fellow at the Wilson Centre in Toronto.

Objective: To review the symptoms of serotonin toxicity (commonly referred to as ) and the causative drugs and their mechanisms of action, and to equip primary care providers with practical strategies to prevent and identify serotonin toxicity.

Quality Of Evidence: PubMed and Google Scholar were searched for relevant articles on serotonin toxicity, the causes, and the differential diagnosis using search terms related to serotonin toxicity (), causes (individual names of drug classes, individual drug names), and diagnosis (). Experts in psychiatric medicine, psychiatric pharmacy, clinical pharmacology, and medical toxicology were consulted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184959PMC
October 2018
8 Reads

Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics.

Sci Total Environ 2019 Feb 1;650(Pt 2):2731-2741. Epub 2018 Oct 1.

Department of Civil and Environmental Engineering, National University of Singapore, Singapore. Electronic address:

While it is well known that fluoxetine is more toxic to aquatic organisms at high pH, the metabolic dysregulations related to observed pH-dependent effects are still poorly understood. In the present study, we utilized a gas chromatography mass spectrometry (GC-MS) based metabolomics approach to assess metabolomic profile changes in developing zebrafish embryos following exposure (2 hpf-96 hpf) to different concentrations of fluoxetine at three environmentally relevant pH values (7.0, 8. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.364DOI Listing
February 2019
5 Reads

Impact of the widespread pharmaceutical pollutant fluoxetine on behaviour and sperm traits in a freshwater fish.

Sci Total Environ 2019 Feb 24;650(Pt 2):1771-1778. Epub 2018 Sep 24.

Monash University, School of Biological Sciences, Melbourne 3800, Australia.

Pharmaceutical pollutants are detected in aquatic habitats and wildlife tissues globally. One widespread contaminant of major concern is the antidepressant fluoxetine, which can affect behavioural and physiological processes in non-target species. Despite this, effects of fluoxetine on wildlife behaviour have seldom been investigated across multiple fitness-related contexts, especially at environmentally realistic concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.294DOI Listing
February 2019
5 Reads

Modulatory effect of quercetin and its glycosylated form on key enzymes and antioxidant status in rats penile tissue of paroxetine-induced erectile dysfunction.

Biomed Pharmacother 2018 Nov 4;107:1473-1479. Epub 2018 Sep 4.

Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, 340001, Nigeria.

This study sought to compare the effects of quercetin and rutin on some enzymes linked to erectile function as well as antioxidant status in penile tissue of paroxetine - induced erectile dysfunction in rats. Animals were randomly divided into twelve groups: normal control (NC), sildenafil (SD), quercetin (QA) (25 and 50 mg/kg), rutin (RU) (25 and 50 mg/kg), PAR (10 mg/kg); PAR + SD; PAR + QA, PAR + RU (25 and 50 mg/kg). After 14 days' treatment, phosphodiesterase-5' (PDE-5'), arginase, adenosine deaminase (ADA), acetylcholinesterase (AChE) and angiotensin-I converting enzyme (ACE) activities as well as malondialdehyde (MDA) and non-protein thiol levels were determined in rat penile tissues. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.08.128DOI Listing
November 2018
9 Reads

Exposure to low concentration of fluoxetine affects development, behaviour and acetylcholinesterase activity of zebrafish embryos.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 6;215:1-8. Epub 2018 Sep 6.

Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Asa Norte, 70910-900 Brasília, Distrito Federal, Brazil.

Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRI) antidepressant widely used in clinics and very often found in environmental samples of urban aquatic ecosystems in concentrations ranging from ng/L to μg/L. Fish populations might be especially susceptible to FLX due to the presence of conserved cellular receptors of serotonin. Neurotoxic effects on fish biota of polluted water bodies may be expected, but there are no sufficient studies in the current literature to elucidate this hypothesis. Read More

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http://dx.doi.org/10.1016/j.cbpc.2018.08.009DOI Listing
January 2019
24 Reads

Psychotropic Drugs and Liver Toxicity.

Am J Ther 2018 Sep/Oct;25(5):e601-e602

Hepatology Unit, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/MJT.0000000000000615DOI Listing
March 2019
2 Reads

Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.

Oxid Med Cell Longev 2018 29;2018:7196142. Epub 2018 Jul 29.

Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Anadolu University, Eskisehir, Turkey.

Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety. Read More

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http://dx.doi.org/10.1155/2018/7196142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087606PMC
December 2018
4 Reads

Effects of waterborne exposure to the antidepressant fluoxetine on swimming, shoaling and anxiety behaviours of the mosquitofish Gambusia holbrooki.

Ecotoxicol Environ Saf 2018 Nov 7;163:646-655. Epub 2018 Aug 7.

Laboratorio de Ecotoxicología Acuática, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina; Instituto de Biodiversidad y Biología Experimental y Aplicada, CONICET-UBA, Ciudad Autónoma de Buenos Aires, Argentina.

Chemical pollution from pharmaceuticals is increasingly recognized as a major hazard to the aquatic biota. Among the wide variety of pharmaceuticals, fluoxetine (FLX) is one of the most widely prescribed antidepressants, and therefore, it is frequently identified in the aquatic environment. As FLX is designed to alter human behaviour and many physiological pathways are conserved across vertebrates, this drug may affect the behaviour of fish living in FLX-polluted environments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.07.085DOI Listing
November 2018
4 Reads

Temporal Profiles and Dose-Responsiveness of Side Effects with Escitalopram and Duloxetine in Treatment-Naïve Depressed Adults.

Behav Sci (Basel) 2018 Jul 17;8(7). Epub 2018 Jul 17.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA.

Side effect profiles of antidepressants are relevant to treatment selection and adherence among patients with major depressive disorder (MDD), but several clinically-relevant characteristics of side effects are poorly understood. We aimed to compare the side effect profiles of escitalopram and duloxetine, including frequencies, time to onset, duration, dose responsiveness, and impact on treatment outcomes. Side effects occurring in 211 treatment-naïve patients with MDD randomized to 12 weeks of treatment with flexibly-dosed escitalopram (10⁻20 mg/day) or duloxetine (30⁻60 mg/day) as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study were evaluated. Read More

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http://dx.doi.org/10.3390/bs8070064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071033PMC
July 2018
18 Reads

Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice.

Eur J Pharmacol 2018 Aug 4;833:451-461. Epub 2018 Jul 4.

Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil. Electronic address:

Depression is one of the most frequent neuropsychiatric diseases in the western world and its physiological causes are not yet fully understood. Since the available antidepressants failed to provide a complete illness remission, the diversification of the therapy in the management of depression could be a useful contribution. The present study aimed to investigate the cholecalciferol capability to revert depressive-like behavior induced by chronic corticosterone (CORT) treatment in mice and its implication on the oxidative stress modulation. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.07.002DOI Listing
August 2018
3 Reads

Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects.

Authors:
Brian A Baldo

Arch Toxicol 2018 Aug 18;92(8):2457-2473. Epub 2018 Jun 18.

Molecular Immunology Unit, Department of Medicine, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, University of Sydney, Sydney, NSW, Australia.

Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic levels of serotonin, and opioid analgesic drugs are now recognized as being involved in some cases of serotonin toxicity especially if administered in conjunction with other serotonergic medications including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants. In March 2016, the FDA issued a Drug Safety Communication concerning the association of the entire class of opioid pain medicines with serotonin toxicity. Read More

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http://dx.doi.org/10.1007/s00204-018-2244-6DOI Listing
August 2018
13 Reads

Memantine rescues prenatal citalopram exposure-induced striatal and social abnormalities in mice.

Exp Neurol 2018 09 18;307:145-154. Epub 2018 Jun 18.

School of Psychology, Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, China. Electronic address:

Prenatal exposure to citalopram (CTM), an antidepressant drug, has been associated with altered behavior, including autism-like symptoms in both human and rodent offspring. However, the neurological basis underlying these abnormal behaviors is not well understood. Here, we examined behavioral, morphological, and biochemical alterations in the male and female offspring of C57BL/6 mouse mothers that had been exposed to CTM during the last trimester of gestation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144886183018
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http://dx.doi.org/10.1016/j.expneurol.2018.06.003DOI Listing
September 2018
7 Reads

The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters.

Neuropharmacology 2018 08 23;138:282-291. Epub 2018 Jun 23.

Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Währingerstraße 13A, 1090, Vienna, Austria; Center for Addiction Research and Science, Medical University Vienna, Waehringerstrasse 13A, 1090 Vienna, Austria. Electronic address:

(±)-cis-4,4'-Dimethylaminorex (4,4'-DMAR) is a new psychoactive substance (NPS) that has been associated with 31 fatalities and other adverse events in Europe between June 2013 and February 2014. We used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-DMAR on human high-affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT). In addition, we assessed its binding affinities to monoamine receptors and transporters. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.06.018DOI Listing
August 2018
6 Reads

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).

Behav Brain Funct 2018 Jun 14;14(1):13. Epub 2018 Jun 14.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China.

Background: With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour. Read More

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http://dx.doi.org/10.1186/s12993-018-0145-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001006PMC
June 2018
16 Reads

Clomipramine Toxicity in a CYP 2D6 Poor Metabolizer Patient Who Suddenly Stopped Smoking.

J Clin Psychopharmacol 2018 08;38(4):389-391

Department of Clinical Pharmacy St Antonius Hospital Nieuwegein, The Netherlands Department of Clinical Psychiatry St Antonius Hospital Nieuwegein, The Netherlands Department of Clinical Pharmacy St Antonius Hospital Nieuwegein, The Netherlands

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http://dx.doi.org/10.1097/JCP.0000000000000896DOI Listing
August 2018
3 Reads

Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant.

Toxicol Sci 2018 Oct;165(2):372-388

Developmental and Reproductive Biology Graduate Program, Institute for Biogenesis Research, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii 96813.

Fluoxetine is one of the most commonly prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Epidemiologic studies have suggested a link between maternal fluoxetine use during pregnancy and an increased incidence of birth defects. However, the mechanisms by which fluoxetine adversely impacts embryonic developments are unknown. Read More

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http://dx.doi.org/10.1093/toxsci/kfy143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154268PMC
October 2018
11 Reads

In vivo investigation on the chronic hepatotoxicity induced by sertraline.

Environ Toxicol Pharmacol 2018 Jul 30;61:107-115. Epub 2018 May 30.

Department of Biological Sciences, College of Science, Jerash University, Jordan. Electronic address:

Although sertraline is widely prescribed as relatively safe antidepressant drug, hepatic toxicity was reported in some patients with sertraline treatment. The present study was conducted to investigate the morphometric, hepatotoxicity, and change in gene expression of drug metabolizing enzymes. Male healthy adult rabbits (Oryctolagus cuniculus) ranging from 1050 to 1100 g were exposed to oral daily doses of sertraline (0, 1, 2, 4, 8 mg/kg) for 9 weeks. Read More

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http://dx.doi.org/10.1016/j.etap.2018.05.021DOI Listing
July 2018
5 Reads

Successful intravenous lipid emulsion therapy: Olanzapine intoxication.

Acute Med 2018 ;17(2):96-97

Haseki Training and Research Hospital, Department of Emergency Medicine, Istanbul, Turkey.

Olanzapine is an antipsychotic drug used in psychiatric diseases. At high doses it exhibits cardiovascular and neurological sideeffects in particular. Lipid emulsion therapy for the removal of medication from plasma in high-dose lipophilic drug use has recently become very widespread. Read More

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October 2018
9 Reads

Toxicological Assessment of Venlafaxine: Acute and Subchronic Toxicity Study in Rats.

Int J Toxicol 2018 Jul/Aug;37(4):327-334. Epub 2018 Jun 3.

3 Psychiatry Department, Faculty of Medicine, Minia University, Menia, Egypt.

Antidepressants are the most commonly prescribed drugs for psychiatric treatment, and venlafaxine (VEN) is one of the most popular options. Venlafaxine is a nontricyclic dual-acting serotonin-norepinephrine reuptake inhibitor. Although an increased incidence of acute toxicity and addiction has been reported, controlled studies examining its toxic effects on different organs are still lacking. Read More

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http://dx.doi.org/10.1177/1091581818777470DOI Listing
March 2019
51 Reads
1.233 Impact Factor

Inhibitory effects of fluoxetine, an antidepressant drug, on masseter muscle nociception at the trigeminal subnucleus caudalis and upper cervical spinal cord regions in a rat model of psychophysical stress.

Exp Brain Res 2018 08 28;236(8):2209-2221. Epub 2018 May 28.

Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274, Gakkocho-Dori, Chuo-ku, Niigata, 951-8514, Japan.

This study aimed to determine whether psychophysical stress conditionings had facilitatory effects on masseter muscle nociception in the central nervous system via serotonergic mechanisms in rats. Two experiments were conducted to assess: (1) whether repeated forced swim stress for 3 days increased the number of Fos-positive neurons evoked by masseter muscle injury due to formalin injection; and (2) whether serotonin-reuptake inhibitor, fluoxetine, administered daily after each stress conditioning, had modulatory roles on Fos expression. The number of Fos-positive cells was quantified in several areas within the trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord regions (Vc areas), including the ventrolateral area of the trigeminal subnucleus interpolaris/Vc transition, and the middle or caudal portion of the Vc regions, since nociceptive neural activity in the Vc region could play critical roles in deep craniofacial nociception. Read More

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http://dx.doi.org/10.1007/s00221-018-5297-0DOI Listing
August 2018
3 Reads

Effects of acute and chronic exposures of fluoxetine on the Chinese fish, topmouth gudgeon Pseudorasbora parva.

Ecotoxicol Environ Saf 2018 Sep 21;160:104-113. Epub 2018 May 21.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, 110016, China. Electronic address:

Fluoxetine is a selective serotonin reuptake inhibitor used as an antidepressant and has been frequently detected in aquatic environments. However, its effects in fish from Asia remain relatively less studied. In this study, the topmouth gudgeon Pseudorasbora parva was exposed to 0, 50, and 200 µg/L of fluoxetine for 4 h and 42 d. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183035
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http://dx.doi.org/10.1016/j.ecoenv.2018.04.061DOI Listing
September 2018
13 Reads

Environmentally relevant concentrations of tramadol and citalopram alter behaviour of an aquatic invertebrate.

Aquat Toxicol 2018 Jul 14;200:226-232. Epub 2018 May 14.

University of South Bohemia in České Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, Vodňany, 389 25, Czech Republic.

Environmental pollution by pharmaceutically active compounds, used in quantities similar to those of pesticides and other organic micropollutants, is increasingly recognized as a major threat to the aquatic environment. These compounds are only partly removed from wastewaters and, despite their low concentrations, directly and indirectly affect behaviour of freshwater organisms in natural habitats. The aim of this study was to behaviourally assess the effects of an opioid painkiller (tramadol) and antidepressant drug (citalopram) on behaviour patterns of a clonal model species, marbled crayfish. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183042
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http://dx.doi.org/10.1016/j.aquatox.2018.05.008DOI Listing
July 2018
16 Reads

Assessment of trazodone-induced cardiotoxicity after repeated doses in rats.

Hum Exp Toxicol 2019 Jan 18;38(1):45-55. Epub 2018 May 18.

1 Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.

Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting results were observed in these studies. Therefore, we aimed to investigate the cardiac adverse effects of TRZ in rats at repeated doses in our study. Read More

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http://journals.sagepub.com/doi/10.1177/0960327118769717
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http://dx.doi.org/10.1177/0960327118769717DOI Listing
January 2019
5 Reads

Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review.

Sci Total Environ 2018 Aug 16;631-632:789-794. Epub 2018 Mar 16.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. Electronic address:

After application, antidepressants, like other pharmaceuticals, are excreted from human body in their native form or as metabolites and enter the aquatic environment via different pathways. As concentrations of antidepressant residues in water continue to increase, their effects on non-target animals are being discussed. The aim of this study is to summarize current knowledge about the effects of wateborne antidepressants on non-target animals living in surface waters - invertebrates, fish and amphibians. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.03.076DOI Listing
August 2018
20 Reads

In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach.

Exp Parasitol 2018 Jun 18;189:19-27. Epub 2018 Apr 18.

Instituto de Investigaciones en Ciencias de la Salud (INICSA) UNC-CONICET, Centro de Estudios e Investigación de la Enfermedad de Chagas y Leishmaniasis, Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Santa Rosa 1085, Córdoba X5000ESU, Argentina. Electronic address:

Combination therapies based on the available drugs have been proposed as promising therapeutic alternatives for many diseases. Clomipramine (CLO) has been found to modify the evolution of the experimental infection. The objective of this study was to evaluate the combined effect of benznidazole (BZ) and clomipramine (CLO) against different life-stages of Trypanosoma cruzi in vitro and their efficacy in a murine model. Read More

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http://dx.doi.org/10.1016/j.exppara.2018.04.016DOI Listing
June 2018
14 Reads

Prospective environmental risk assessment of mixtures in wastewater treatment plant effluents - Theoretical considerations and experimental verification.

Water Res 2018 09 14;140:56-66. Epub 2018 Apr 14.

UBA - German Environment Agency, Wörlitzer Platz 1, 06844 Dessau-Roßlau, Germany.

The aquatic environment is continually exposed to a complex mixture of chemicals, whereby effluents of wastewater treatment plants (WWTPs) are one key source. The aim of the present study was to investigate whether environmental risk assessments (ERAs) addressing individual substances are sufficiently protective for such coincidental mixtures. Based on a literature review of chemicals reported to occur in municipal WWTP effluents and mode-of-action considerations, four different types of mixtures were composed containing human pharmaceuticals, pesticides, and chemicals regulated under REACH. Read More

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http://dx.doi.org/10.1016/j.watres.2018.04.031DOI Listing
September 2018
7 Reads

Does fluoxetine exposure affect hypoxia tolerance in the Gulf toadfish, Opsanus beta?

Aquat Toxicol 2018 Jun 23;199:55-64. Epub 2018 Mar 23.

Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA. Electronic address:

Due to ineffective wastewater treatment technologies, pharmaceuticals such as the selective serotonin reuptake inhibitors (SSRIs)-a common class of antidepressants which inhibit the serotonin transporter (SERT)-can be found in surface waters and marine receiving waters near wastewater effluents. Understanding how exposure to these chemicals might impact non-target organisms, especially combined with other environmental stressors like hypoxia, is essential in order to thoroughly evaluate environmental risk. It was hypothesized that both acute and chronic exposure to the SSRI fluoxetine (FLX) would interfere with the metabolic hypoxia response of the Gulf toadfish, Opsanus beta. Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.03.023DOI Listing
June 2018
7 Reads

The antidepressant fluoxetine alters mechanisms of pre- and post-copulatory sexual selection in the eastern mosquitofish (Gambusia holbrooki).

Environ Pollut 2018 Jul 20;238:238-247. Epub 2018 Mar 20.

School of Biological Sciences, Monash University, Victoria, Australia; Department of Biosciences, Åbo Akademi University, Turku, Finland.

Contamination of aquatic habitats with pharmaceuticals is a major environmental concern. Recent studies have detected pharmaceutical pollutants in a wide array of ecosystems and organisms, with many of these contaminants being highly resistant to biodegradation and capable of eliciting sub-lethal effects in non-target species. One such pollutant is fluoxetine, a widely prescribed antidepressant, which is frequently detected in surface waters globally and can alter physiology and behaviour in aquatic organisms. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.03.006DOI Listing
July 2018
3 Reads

The effects of fluoxetine on attachment and righting behaviours in marine (Gibbula unbilicalis) and freshwater (Lymnea stagnalis) gastropods.

Ecotoxicology 2018 May 9;27(4):477-484. Epub 2018 Mar 9.

Institute of Marine Sciences, School of Biological Sciences, University of Portsmouth, Ferry Road, Portsmouth, PO4 9LY, UK.

Recent studies have highlighted that antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) entering aquatic systems through wastewater discharges might impact organisms at environmentally relevant concentrations. In this study, two snail species (Gibbula unbilicalis and Lymnea stagnalis) representing the marine and freshwater environments were exposed to a large range of fluoxetine concentrations (1 ng L-1 mg L) and two distinct behaviours (foot detachment and righting time) were recorded. Fluoxetine significantly caused foot detachment only at the higher of the concentrations (1 mg L) in both species during the course of this short term 1. Read More

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http://dx.doi.org/10.1007/s10646-018-1919-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897494PMC
May 2018
4 Reads

Overdoses and Substance Toxicity in Patients Admitted to Intensive Care Units in a Midwestern U.S. City.

J Trauma Nurs 2018 Mar/Apr;25(2):87-91

Internal Medicine Residency Program, University of Iowa-Des Moines (Drs Schuring, Dodge, Whitcomb, Wall, and Smith); College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa (Dr Wall); and Pulmonary and Critical Care Medicine, The Iowa Clinic, Des Moines, Iowa (Dr Hicklin).

Toxic exposures with serious outcomes have increased over the last decade. Limited data exists on the pattern and outcomes of overdose-exposure patients requiring intensive care unit (ICU) admission. The primary objective of this study was to characterize the causes, treatments, and outcomes of toxic exposures in a mid-sized Midwestern health system. Read More

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http://dx.doi.org/10.1097/JTN.0000000000000349DOI Listing
September 2018
10 Reads

Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents.

Pharmacol Res Perspect 2018 02;6(1)

CNS Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.

Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D receptor antagonism. TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] is a novel phosphodiesterase 10A inhibitor that activates both direct and indirect pathway MSNs through increasing both cAMP and cGMP levels by inhibition of their degradation. The activation of indirect pathway MSNs through the distinct mechanism of action of these drugs raises the possibility of augmented pharmacological effects by combination therapy. Read More

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http://dx.doi.org/10.1002/prp2.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817828PMC
February 2018
5 Reads

Early postnatal treatment with clomipramine induces female sexual behavior and estrous cycle impairment.

Pharmacol Biochem Behav 2018 03 31;166:27-34. Epub 2018 Jan 31.

Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, Apartado Postal 55 535, C.P. 09340 Ciudad de México, Mexico. Electronic address:

Administration of clomipramine (CMI), a tricyclic antidepressant, in early stages of development in rats, is considered an animal model for the study of depression. This pharmacological manipulation has induced behavioral and physiological alterations, i.e. Read More

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http://dx.doi.org/10.1016/j.pbb.2018.01.004DOI Listing
March 2018
2 Reads