1,796 results match your criteria Toxicity Selective Serotonin Reuptake Inhibitor

Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride.

Sci Total Environ 2021 Sep 30;786:147434. Epub 2021 Apr 30.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.

Sertraline hydrochloride (Ser-HCl) is an effective and commonly used antidepressant drug, which is also frequently detected in aquatic environments. Our previous research showed that Ser-HCl changes the community composition of aquatic microbiome, but the understanding of the expression of functional pathways in microbial communities is still incomplete; to address this knowledge gap, we used meta-transcriptomics analysis to evaluate the toxicity of Ser-HCl to natural aquatic microbial communities cultured in laboratory microcosms. Meta-transcriptomic results show that a 15-day exposure to 50 μg/L Ser-HCl significantly changed the functional expression activity of aquatic microbial communities. Read More

View Article and Full-Text PDF
September 2021

Alteration of predatory behaviour and growth in juvenile cuttlefish by fluoxetine and venlafaxine.

Chemosphere 2021 Aug 17;277:130169. Epub 2021 Mar 17.

NORMANDIE UNIV, UNICAEN, UNIV RENNES, CNRS, EthoS (Éthologie animale et humaine) - UMR 6552, F-14000, Caen, France. Electronic address:

Antidepressants in coastal waters may affect ontogeny of predatory behaviour in cuttlefish, which may, as a result, affect growth of newly-hatched cuttlefish. We investigated the effects of two of the most prescribed antidepressants, fluoxetine (FLX) and venlafaxine (VEN) in environmentally realistic concentrations on the predatory behaviour of hatchlings of Sepia officinalis. Newly-hatched cuttlefish were exposed from 1 h (i. Read More

View Article and Full-Text PDF

Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca channels as sensors.

Toxicol Appl Pharmacol 2021 05 27;419:115513. Epub 2021 Mar 27.

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, United States of America. Electronic address:

The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug whose overdose can be fatal. It is a potent substrate at DAT and SERT where its simplest secondary amine (N-methyl 4-MA) retains substrate activity at them. Read More

View Article and Full-Text PDF

Effects of environmental antidepressants on colour change and locomotor behaviour in juvenile shore crabs, Carcinus maenas.

Aquat Toxicol 2021 May 12;234:105808. Epub 2021 Mar 12.

NORMANDIE UNIV, UNILEHAVRE, FR CNRS 3730 SCALE, UMR-I02, Environmental Stress and Biomonitoring of Aquatic Environments (SEBIO), 76600 LE HAVRE, France. Electronic address:

Juvenile crabs of Carcinus maenas thrive in coastal waters reputed to be the receptacle of continental pollution. Amongst the many pollutants encountered, antidepressants, such as fluoxetine (FLX) and venlafaxine (VEN), often detected at the ng•L range, are particularly worrying because of their action on the levels of monoamines, such as serotonin, noradrenaline and dopamine. In crustaceans, those monoamines are involved in colour change through their action on neuropeptide hormones. Read More

View Article and Full-Text PDF

Gene alteration in zebrafish exposed to a mixture of substances of abuse.

Environ Pollut 2021 Jun 24;278:116777. Epub 2021 Feb 24.

Department of Biology, Murray State University, Murray, KY, United States.

A recent surge in the use and abuse of diverse prescribed psychotic and illicit drugs necessitates the surveillance of drug residues in source water and the associated ecological impacts of chronic exposure to the aquatic organism. Thirty-six psychotic and illicit drug residues were determined in discharged wastewater from two centralized municipal wastewater treatment facilities and two wastewater receiving creeks for seven consecutive days in Kentucky. Zebrafish (Danio rerio) larvae were exposed to the environmental relevant mixtures of all drug residues, all illicit drugs, and all prescribed psychotic drugs. Read More

View Article and Full-Text PDF

Double-edged sword: Fluoxetine and ibuprofen as development jeopardizers and apoptosis' inducers in common toad, Bufo bufo, tadpoles.

Sci Total Environ 2021 Jul 18;776:145945. Epub 2021 Feb 18.

University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy. Electronic address:

Nowadays the presence of pharmaceuticals in the environment is a real problem. Ending up in aquatic environments they negatively affect non-target organisms. Considering the limited studies on the negative effects of pharmaceuticals in amphibians, a better understanding of the mechanisms underlying the sub-lethal effects of drug mixtures in wildlife is an urgent call. Read More

View Article and Full-Text PDF

Natural daily patterns in fish behaviour may confound results of ecotoxicological testing.

Environ Pollut 2021 May 13;276:116738. Epub 2021 Feb 13.

Animal Ecology, Global Change and Sustainable Development, KU Leuven, Leuven, Belgium; Centre for Environmental Management, University of the Free State, Bloemfontein, South Africa. Electronic address:

Low doses of neuroactive chemicals end up in the environment and disrupt behaviour of non-target organisms. Although a whole range of studies have documented pollutant-induced changes in behaviour, natural daily variability in behaviour is rarely taken into account. This is surprising because biological rhythms may affect the outcome of experiments, are adaptive and are expected to be sensitive to neurochemical exposure. Read More

View Article and Full-Text PDF

[Sertraline-induced chronic eosinophilic pneumonia].

Rev Mal Respir 2021 Feb 10;38(2):210-214. Epub 2021 Feb 10.

Service d'anatomopathologie, universitair ziekenhuis Leuven-Gasthuisberg, 3000 Leuven, Belgique.

Introduction: Sertraline is a selective serotonin reuptake inhibitor which is often used as first-line treatment for depression. Several patterns of interstitial lung disease attributable to sertraline have been reported in the literature.

Case Report: A 69-year-old patient, who had been taking sertraline to treat severe depression for 10 months, presented with a deterioration in his general condition and respiratory symptoms found to be associated with bilateral pneumonitis. Read More

View Article and Full-Text PDF
February 2021

Psychoactive pollution suppresses individual differences in fish behaviour.

Proc Biol Sci 2021 02 10;288(1944):20202294. Epub 2021 Feb 10.

School of Biological Sciences, Monash University, Australia.

Environmental contamination by pharmaceuticals is global, substantially altering crucial behaviours in animals and impacting on their reproduction and survival. A key question is whether the consequences of these pollutants extend beyond mean behavioural changes, restraining differences in behaviour between individuals. In a controlled, two-year, multigenerational experiment with independent mesocosm populations, we exposed guppies () to environmentally realistic levels of the ubiquitous pollutant fluoxetine (Prozac). Read More

View Article and Full-Text PDF
February 2021

Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats.

Epilepsy Behav 2021 03 6;116:107797. Epub 2021 Feb 6.

Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis Samsun, Turkey.

Aim: Depression is the major psychiatric disorder in patients with epilepsy. Vortioxetine is a novel antidepressant drug for the treatment of major depressive disorders. In the present study, effects of vortioxetine were evaluated in different experimental epilepsy models of rats. Read More

View Article and Full-Text PDF

Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?

Front Pharmacol 2020 20;11:609811. Epub 2021 Jan 20.

Institute of Clinical Pharmacology, University Medical Center Göttingen, Göttingen, Germany.

Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some might also be substrates of polyspecific organic cation transporters (OCTs) that mediate uptake in liver and kidneys for metabolism and excretion. Read More

View Article and Full-Text PDF
January 2021

Zygotic exposure to venlafaxine disrupts cortisol stress axis activity in multiple generations of zebrafish.

Environ Pollut 2021 Apr 20;274:116535. Epub 2021 Jan 20.

Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada. Electronic address:

Ubiquitous use of antidepressants has resulted in increased concentrations of these pharmaceuticals in waterways receiving municipal wastewater effluent. Amongst these, venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is commonly found at concentrations surpassing 1 ppb in surface waters. We recently showed that the deposition of venlafaxine in zebrafish (Danio rerio) embryos impacts neural development in the hypothalamus, suggesting the possibility of neuroendocrine disruptions due to this antidepressant. Read More

View Article and Full-Text PDF

Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures.

Pediatrics 2021 02;147(2)

Children's Hospital Colorado, Aurora, Colorado.

Serotonergic medications are used for the prevention and treatment of depression during pregnancy. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors (SNRIs) can cause poor neonatal adaptation, which has been attributed to withdrawal versus toxicity. Bupropion, a norepinephrine-dopamine reuptake inhibitor, is often used as an adjunctive agent to selective serotonin reuptake inhibitors or SNRIs for refractory depression. Read More

View Article and Full-Text PDF
February 2021

Environmentally relevant concentrations of sertraline disrupts behavior and the brain and liver transcriptome of juvenile yellow catfish (Tachysurus fulvidraco): Implications for the feeding and growth axis.

J Hazard Mater 2021 05 30;409:124974. Epub 2020 Dec 30.

Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.

Sertraline (SER) is one of the most prevalent antidepressants detected in aquatic environments, but its impact on fish behavior and growth remain poorly understood. As such, behavior and growth were assessed in yellow catfish (Tachysurus fulvidraco) following SER exposure. SER induced shoaling, reduced food consumption and growth, and increased cannibalism at environmentally relevant concentrations. Read More

View Article and Full-Text PDF

Exposure to tricyclic antidepressant nortriptyline affects early-life stages of zebrafish (Danio rerio).

Ecotoxicol Environ Saf 2021 Mar 8;210:111868. Epub 2021 Jan 8.

Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, UnB, 70910-900 Brasília, Distrito Federal, Brazil. Electronic address:

Psychiatric drugs are among the leading medications prescribed for humans, with their presence in aquatic environments raising concerns relating to potentially harmful effects on non-target organisms. Nortriptyline (NTP) is a selective serotonin-norepinephrine reuptake inhibitor antidepressant, widely used in clinics and found in environmental water matrices. In this study, we evaluated the toxic effects of NTP on zebrafish (Danio rerio) embryos and early larval stages. Read More

View Article and Full-Text PDF

Molecular and behavioral responses of zebrafish embryos/larvae after sertraline exposure.

Ecotoxicol Environ Saf 2021 Jan 23;208:111700. Epub 2020 Nov 23.

Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611 USA.

Sertraline (SER) is one of the most frequently detected antidepressant drugs in aquatic environments. However, knowledge regarding SER-induced behavioral alterations in fish is insufficient, as well as the mechanisms underlying SER-induced toxicity. The present study aimed to determine behavioral and molecular responses in larval fish following SER exposure with a focus on its mode of action. Read More

View Article and Full-Text PDF
January 2021

New insights into cardiotoxicity induced by chiral fluoxetine at environmental-level: Enantioselective arrhythmia in developmental zebrafish (Danio rerio).

Environ Pollut 2021 Feb 5;270:116182. Epub 2020 Dec 5.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products / Key Laboratory of Detection for Pesticide Residues and Control of Zhejiang Province, Institute of Quality and Standard of Agro-Products, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China. Electronic address:

Fluoxetine is frequently detected in aquatic environment, and chronic FLX exposure exhibits adverse effects on aquatic communities. Its chirality makes the adverse effects more complicated. This study aimed at the enantioselective cardiotoxicity in developmental zebrafish induced by racemic (rac-)/S-/R-fluoxetine. Read More

View Article and Full-Text PDF
February 2021

Time-, dose- and transgenerational effects of fluoxetine on the behavioural responses of zebrafish to a conspecific alarm substance.

Environ Pollut 2021 Feb 27;270:116164. Epub 2020 Nov 27.

Biology Department, Sultan Qaboos University, Muscat, PO Box 36, 123, Oman. Electronic address:

Despite publication of numerous of papers, the effects of fluoxetine on fish behaviour remains mired in controversy and contradiction. One reason for this controversy is that fluoxetine displays distinct and opposing acute and chronic effects. A second reason is that most studies have been limited to two or at the most three concentrations. Read More

View Article and Full-Text PDF
February 2021

Linezolid use for the treatment of multidrug-resistant tuberculosis, TB centers of excellence, United States, 2013-2018.

J Clin Tuberc Other Mycobact Dis 2021 Feb 16;22:100201. Epub 2020 Nov 16.

U.S. Centers for Disease Control and Prevention, Division of TB Elimination, Atlanta, GA, United States.

Background: In 2019, the World Health Organization released guidelines reflecting major changes in multidrug-resistant tuberculosis (MDR-TB) management-prioritizing fluoroquinolones, bedaquiline, and linezolid (LZD) while de-emphasizing previously favored injectable agents. In some cases, linezolid use is associated with gastrointestinal intolerance, mitochondrial toxicity, and significant drug interactions. CDC's Division of Tuberculosis Elimination supports a network of regional TB Centers of Excellence, which provide medical consultation to healthcare providers. Read More

View Article and Full-Text PDF
February 2021

Autologous Hematopoietic Stem Cell Transplantation for Stiff-Person Spectrum Disorder: A Clinical Trial.

Neurology 2021 02 14;96(6):e817-e830. Epub 2020 Dec 14.

From the Division of Immunotherapy (R.K.B., X.H., K.Q., I.A.), Department of Medicine, Department of Neurology (R.B., T.S.), Department of Preventive Medicine (I.H.), and Department of Pathology and Cell and Developmental Biology (T.S.), Northwestern University, Chicago, IL; and Department of Neurology (J.R.), University of Utah, Salt Lake City.

Objective: To test the hypothesis that autologous nonmyeloablative hematopoietic stem cell transplantation (HSCT) is safe and shows efficacy in the treatment of stiff-person spectrum disorder (SPSD).

Methods: Twenty-three participants were treated in a prospective open-label cohort study of safety and efficacy. After stem cell mobilization with cyclophosphamide (2 g/m) and filgrastim (5-10 µg/kg/d), participants were treated with cyclophosphamide (200 mg/kg) divided as 50 mg/kg IV on day -5 to day -2; rabbit anti-thymocyte globulin (thymoglobulin) given intravenously at 0. Read More

View Article and Full-Text PDF
February 2021

Study of the photoinduced transformations of sertraline in aqueous media.

Sci Total Environ 2021 Feb 27;756:143805. Epub 2020 Nov 27.

Department of Chemistry, University of Ioannina, Laboratory of Analytical Chemistry, Ioannina 45 110, Greece. Electronic address:

In the present study, the photoinduced degradation of the antidepressant drug sertraline under artificial solar radiation was examined. Photolysis was studied under different experimental conditions to explore its photolytic fate in the aqueous environment. Photolytic degradation kinetics were carried out in ultrapure water, wastewater effluent, as well as in the presence of dissolved organic matter (humic acids), bicarbonate and nitrate ions which enabled their assessment on sertraline photo-transformation. Read More

View Article and Full-Text PDF
February 2021

Understanding Mechanisms Underlying Non-Alcoholic Fatty Liver Disease (NAFLD) in Mental Illness: Risperidone and Olanzapine Alter the Hepatic Proteomic Signature in Mice.

Int J Mol Sci 2020 Dec 8;21(24). Epub 2020 Dec 8.

Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA.

Patients with severe mental illness have increased mortality, often linked to cardio-metabolic disease. Non-alcoholic fatty liver disease (NAFLD) incidence is higher in patients with schizophrenia and is exacerbated with antipsychotic treatment. NAFLD is associated with obesity and insulin resistance, both of which are induced by several antipsychotic medications. Read More

View Article and Full-Text PDF
December 2020

Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes.

Elife 2020 11 17;9. Epub 2020 Nov 17.

Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.

Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been considered to result from obesity-associated insulin resistance. Olanzapine is particularly well known for this effect. However, clinical studies have suggested that olanzapine-induced hyperglycemia in certain patients cannot be explained by such a generalized mechanism. Read More

View Article and Full-Text PDF
November 2020

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus).

Arch Environ Contam Toxicol 2020 Nov 5;79(4):478-487. Epub 2020 Nov 5.

School of Natural Sciences, Technology and Environmental Studies, Södertörn University, Alfred Nobels allé 7, 141 89, Huddinge, Sweden.

Selective serotonin reuptake inhibitors (SSRIs) are psychotropic pharmaceuticals used as antidepressants. SSRIs are commonly found in surface waters in populated areas across the globe. They exert their effect by blocking the serotonin re-uptake transporter in the presynaptic nerve ending. Read More

View Article and Full-Text PDF
November 2020

Zygotic Venlafaxine Exposure Impacts Behavioral Programming by Disrupting Brain Serotonin in Zebrafish.

Environ Sci Technol 2020 11 3;54(22):14578-14588. Epub 2020 Nov 3.

Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada, T2N 1N4.

The antidepressant venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is present in surface waters downstream of wastewater treatment plants. We previously showed that zygotic venlafaxine deposition alters larval behavior in zebrafish (), but the mechanisms were unknown. Here we tested the hypothesis that venlafaxine disrupts central serotonergic development, leading to impaired behavioral responses in zebrafish larvae. Read More

View Article and Full-Text PDF
November 2020

Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain.

Sci Rep 2020 10 29;10(1):18581. Epub 2020 Oct 29.

Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego, 9500 Gilman Drive Mail Code 0673, La Jolla, CA, 92093, USA.

Antipsychotic drugs (AP) are used to treat a multitude of psychiatric conditions including schizophrenia and bipolar disorder. However, APs also have metabolic side effects including increased food intake and body weight, but the underlying mechanisms remain unknown. We previously reported that minocycline (MINO) co-treatment abrogates olanzapine (OLZ)-induced hyperphagia and weight gain in mice. Read More

View Article and Full-Text PDF
October 2020

Rapid, Precise and Affordable Estimation of Venlafaxine and Its Metabolites in Highly Polluted Effluent Waters: Proof-of-Concept for Methodology.

Molecules 2020 Oct 19;25(20). Epub 2020 Oct 19.

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Widespread presence of pharmaceuticals and their metabolites in the environment of industrialized countries is an emerging global concern. Potential contamination of the soil and water by such pharmacologically active substances poses serious ecotoxicological implications. Several studies assessing the long-term ecological risks of pharmaceutical contaminants mainly focus on the risk assessment of the parent drug, while the potential contributions of their metabolites is often neglected. Read More

View Article and Full-Text PDF
October 2020

Olanzapine for Prevention of Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy: Investigator-Initiated, Randomized, Open-Label Trial.

J Clin Oncol 2020 11 15;38(32):3785-3793. Epub 2020 Sep 15.

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Chemotherapy-induced nausea and vomiting (CINV) is a significant toxicity of chemotherapy. Olanzapine is recommended in adult patients for the prevention of CINV but has not been prospectively investigated in children.

Methods: This investigator-initiated, randomized, open-label trial evaluated olanzapine in children (ages 5-18 years) scheduled to receive the first cycle of highly emetogenic chemotherapy (HEC). Read More

View Article and Full-Text PDF
November 2020

Carnosic acid prevented olanzapine-induced metabolic disorders through AMPK activation.

Mol Biol Rep 2020 Oct 14;47(10):7583-7592. Epub 2020 Sep 14.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Olanzapine, an atypical antipsychotic medication, has been associated with weight gain and metabolic toxicity, especially in long term usage. Carnosic acid (CA), a major constituent of rosemary extract, has been shown to improve metabolic abnormalities. In this experiment, the effect of CA on olanzapine-induced obesity and metabolic toxicity has been evaluated. Read More

View Article and Full-Text PDF
October 2020

Lipid Emulsion Treatment for Trazodone Toxicity-Induced Coma.

Clin Neuropharmacol 2020 Nov/Dec;43(6):201

Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju-si, Republic of Korea Department of Anesthesiology and Pain Medicine, Gyeongsang National University, College of Medicine, Gyeongsang National University Hospital, Institute of Health Sciences, Gyeonsang National University, Jinju-si, Republic of Korea

View Article and Full-Text PDF
February 2021