1,711 results match your criteria Toxicity Selective Serotonin Reuptake Inhibitor


Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells.

Life Sci 2020 Aug 22;255:117827. Epub 2020 May 22.

Department of Biomedical Education and Anatomy, College of Medicine, The Ohio State University, 279 Hamilton Hall, 1645 Neil Ave., Columbus, OH 43210, USA; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:

Aims: Data suggest pharmacological treatment of depression with selective serotonin reuptake inhibitors (SSRI) may impair bone health. Our group has previously modeled compromised craniofacial healing after treatment with sertraline, a commonly prescribed SSRI, and hypothesized potential culprits: alterations in bone cells, collagen, and/or inflammation. Here we interrogate bone lineage cell alterations due to sertraline treatment as a potential cause of the noted compromised bone healing. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117827DOI Listing

Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients.

Sci Rep 2020 May 21;10(1):8394. Epub 2020 May 21.

The Wolfson Centre for Personalised Medicine, The MRC Centre for Drug Safety Science, Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukaemia (CML), can cause lower gastrointestinal (GI) toxicity which is manifested as diarrhoea. The mechanisms are not fully understood. The enteroendocrine signalling compound, serotonin (5-HT), is important for regulating peristaltic motion, fluid secretion and visceral hypersensitivity in the GI tract, and has been implicated in diseases such as irritable bowel syndrome. Read More

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http://dx.doi.org/10.1038/s41598-020-65350-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242433PMC

Insights into serotonergic and antioxidant mechanisms involved in antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran in mice.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Aug 1;102:109956. Epub 2020 May 1.

Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Bioquímica e Neurofarmacologia Molecular (LABIONEM), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas (UFPel), CEP 96010-900 Pelotas, RS, Brazil. Electronic address:

Monoaminergic and oxidative dysfunctions have been reported to play a role in depression. The present study investigated the antioxidant potential as well as the antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) in male Swiss mice. Time and dose-response curves were analyzed with the forced swim (FST) and tail suspension (TST) tests, in which SeBZF1 elicited antidepressant-like effects. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.109956DOI Listing

Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats.

Metab Brain Dis 2020 Jun 27;35(5):739-751. Epub 2020 Feb 27.

Laboratory of Toxicology, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil.

Ayahuasca is a hallucinogenic beverage that affects the serotonergic system and have therapeutic potential for many diseases and disorders, including depression and drug addiction. The objectives of this study were to evaluate the potential toxic effects of ayahuasca on rats after chronic exposure, and the levels of monoamines, their metabolites and the brain-derived neurotrophic factor (BDNF) in the brain. Female and male rats were treated orally for 28 days with HO (control), fluoxetine (FLX), a selective serotonin reuptake inhibitor antidepressant, or ayahuasca (Aya) at doses of 0. Read More

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http://dx.doi.org/10.1007/s11011-020-00547-wDOI Listing

Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish.

Sci Total Environ 2020 Apr 7;712:136564. Epub 2020 Jan 7.

MARE - Marine and Environmental Sciences Centre, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal; Departamento de Biologia Animal, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Pharmaceutical compounds are continuously released into the aquatic environment, resulting in their ubiquitous presence in many estuarine and coastal systems. As pharmaceuticals are designed to produce effects at very low concentrations and target specific evolutionary conserved pathways, there are growing concerns over their potential deleterious effects to the environment and specifically to aquatic organisms, namely in early life-stages. In this context, the long-term effects of exposure of juvenile meagre Argyrosomus regius to three different pharmaceuticals were investigated. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.136564DOI Listing

Immunohistological Biomarkers of Toxicity by a Pharmaceutical Antidepressant in the Freshwater Cichlid Fish Cichlasoma dimerus (Teleostei, Cichliformes).

Bull Environ Contam Toxicol 2020 Feb 1;104(2):180-184. Epub 2020 Jan 1.

Laboratorio de Ecotoxicología Acuática, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.

Melano-macrophage centers (MMCs) are nodular clusters of pigmented macrophages, implicated in homeostasis and destruction and recycling of endogenous and exogenous material. They can increase in size and/or frequency under environmental stress resulting in immunohistological biomarkers of water quality. Fluoxetine (FLX), a commonly prescribed antidepressant, can cause neuroendocrine, behavioral and reproductive alterations in teleost fish. Read More

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http://dx.doi.org/10.1007/s00128-019-02770-3DOI Listing
February 2020

Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT, 5-HT, and the serotonin transporter.

Bioorg Med Chem Lett 2020 Feb 12;30(4):126882. Epub 2019 Dec 12.

Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea. Electronic address:

Development of highly effective, safe, and fast-acting anti-depressants is urgently required for the treatment of major depressive disorder. It has been suggested that targeting 5-HT and 5-HT in addition to inhibition of serotonin reuptake may be beneficial in generating anti-depressant agents with better pharmacology and less adverse effects. We have developed phthalazinone-based compounds that potently bind to 5-HT, 5-HT, and the serotonin transporter. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.126882DOI Listing
February 2020

Magnetic solid-phase extraction coupled with UHPLC-MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples.

Bioanalysis 2020 Jan;12(1):35-52

Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, PR China.

Routine therapeutic drug monitoring is highly recommended since common antidepressant combinations increase the risk of drug-drug interactions or overlapping toxicity. A magnetic solid-phase extraction by using C-functionalized magnetic silica nanoparticles (C-FeO@SiO NPs) as sorbent was proposed for rapid extraction of venlafaxine, paroxetine, fluoxetine, norfluoxetine and sertraline from clinical plasma and urine samples followed by ultra-HPLC-MS/MS assay.  The synthesized C-FeO@SiO NPs showed high magnetization and efficient extraction for the analytes. Read More

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http://dx.doi.org/10.4155/bio-2019-0171DOI Listing
January 2020

The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss).

Sci Total Environ 2020 Mar 22;708:135082. Epub 2019 Nov 22.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy. Electronic address:

The worldwide consumption of antidepressants is raising as well as their concentrations in the aquatic environment. This increases the risk of food chain contamination and bioaccumulation in aquatic biota. The aim of this study was to describe a potential risk of sertraline as a pollutant from water environment, wherein rainbow trout (Oncorhynchus mykiss) has been chosen as the test organism, because predatory fish are on the top of the food chain in the aquatic environment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.135082DOI Listing
March 2020
5 Reads

Vilazodone poisoning: a systematic review.

Clin Toxicol (Phila) 2020 May 28;58(5):360-367. Epub 2019 Nov 28.

Division of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Vilazodone is a novel antidepressant approved for the treatment of major depressive disorder. It acts as a serotonin reuptake inhibitor and 5-HT1A partial agonist. It may lead to a more rapid rise in serotonin concentration in the synaptic cleft than selective serotonin reuptake inhibitors (SSRIs), which could potentially cause more severe toxicity in overdose. Read More

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http://dx.doi.org/10.1080/15563650.2019.1691221DOI Listing

Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination.

Environ Sci Pollut Res Int 2020 Jan 25;27(2):1941-1955. Epub 2019 Nov 25.

Research Unit of Analysis and Process Applied to the Environment-APAE UR17ES32, Higher Institute of Applied Sciences and Technology Mahdia "ISSAT", University of Monastir, 5100, Mahdia, Tunisia.

In the present study, the occurrence of 40 pharmaceuticals belonging to several therapeutic groups was investigated for the first time in hospital effluent, wastewater treatment plant influent and effluent, and seawater in Mahdia, Tunisia. Forty-six samples were collected within a 6-month sampling period. Pharmaceuticals were analyzed using solid-phase extraction followed by ultra-performance liquid chromatography-triple quadrupole mass spectrometry. Read More

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http://dx.doi.org/10.1007/s11356-019-06866-5DOI Listing
January 2020
2.828 Impact Factor

Two antidepressants fluoxetine and sertraline cause growth retardation and oxidative stress in the marine rotifer Brachionus koreanus.

Aquat Toxicol 2020 Jan 1;218:105337. Epub 2019 Nov 1.

Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

To understand effects of two widely used antidepressant on the antioxidant defense mechanism in the marine rotifer Brachionus koreanus, we assessed acute toxicity and measured population growth, reactive oxygen species (ROS) levels, glutathione (GSH) levels, and antioxidant enzymatic activities (GST, GR, and SOD) in response to fluoxetine hydrochloride (FLX) and sertraline hydrochloride (SER). The no observed effect concentration-24 h of fluoxetine and sertraline were 1000 μg/L and 450 μg/L, respectively, whereas the median lethal concentration (LC50)-24 h of fluoxetine and sertraline were 1560 μg/L and 507 μg/L, respectively. Both fluoxetine and sertraline caused significant reduction (P < 0. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.105337DOI Listing
January 2020
5 Reads
3.451 Impact Factor

Determination and photodegradation of sertraline residues in aqueous environment.

Environ Pollut 2020 Jan 23;256:113431. Epub 2019 Oct 23.

Jozef Stefan Institute, Department of Environmental Sciences, Jamova 39, Ljubljana, Slovenia; Jozef Stefan International Postgraduate School, Jamova 39, Ljubljana, Slovenia. Electronic address:

Sertraline is an antidepressant drug that has been frequently reported in the aquatic environment and biota. While the research has mostly dealt with its occurrence and toxicity, there is a lack of information pertaining to its environmental transformation. The present study aimed to fill in these gaps by giving an insight into mechanisms of sertraline phototransformation in surface waters, which was recognized as the main transformation pathway for this contaminant. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113431DOI Listing
January 2020

Exposure paradigm of fluoxetine impacted the Faxonius virilis agonistic behavior differently.

Sci Total Environ 2020 Jan 4;699:134300. Epub 2019 Sep 4.

Laboratory for Sensory Ecology, Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA; University of Michigan Biological Station, Pellston, MI 49769, USA.

Pharmaceutically active compounds are major contaminants of aquatic environments. The effects on aquatic organisms have been assessed mostly through eco-toxicological tests performed using static exposure systems or flow through systems with constant concentrations. Yet, constant concentration exposures ignore the spatio-temporal dynamics of chemicals in flowing environments. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.134300DOI Listing
January 2020

Environmental concentration of fluoxetine disturbs larvae behavior and increases the defense response at molecular level in zebrafish (Danio rerio).

Environ Sci Pollut Res Int 2019 Dec 28;26(34):34943-34952. Epub 2019 Oct 28.

Department of Biosciences, University of Milan, via Celoria 26, 20133, Milan, Italy.

Fluoxetine (FLX) is one of the main antidepressants used worldwide. After human use, FLX enters the aquatic ecosystems, where it has commonly detected in the high ng/L concentration range. Several investigations have shown that exposure to different concentrations of FLX caused different adverse effects towards a number of aquatic species. Read More

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http://dx.doi.org/10.1007/s11356-019-06619-4DOI Listing
December 2019

Hidden in the sand: Alteration of burying behaviour in shore crabs and cuttlefish by antidepressant exposure.

Ecotoxicol Environ Saf 2019 Dec 11;186:109738. Epub 2019 Oct 11.

Normandie Univ, UNILEHAVRE, FR CNRS 3730 SCALE, UMR-I02, Environmental Stress and Biomonitoring of Aquatic Environments (SEBIO), 76600, Le Havre, France. Electronic address:

Pharmaceuticals such as antidepressants are constantly released into the aquatic environment. Consequently, fluoxetine (FLX) and venlafaxine (VEN), the active molecules of Prozac© and Effexor©, are detected up to several µg.L in freshwater and marine coastal waters. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.109738DOI Listing
December 2019

Analysis of tail coiling activity of zebrafish (Danio rerio) embryos allows for the differentiation of neurotoxicants with different modes of action.

Ecotoxicol Environ Saf 2019 Dec 10;186:109754. Epub 2019 Oct 10.

Aquatic Ecology and Toxicology Section, Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, Heidelberg, D-69120, Germany.

In (eco)toxicology, there is a critical need for efficient methods to evaluate the neurotoxic potential of environmental chemicals. Recent studies proposed analysis of early coiling activity in zebrafish embryos as a powerful tool for the identification of neurotoxic compounds. In order to demonstrate that the analysis of early tail movements of zebrafish embryos allows for the discrimination of neurotoxicants acting via different mechanisms, the present study investigated the effects of four different neurotoxicants on the embryogenesis (fish embryo toxicity test) and early tail coiling movements of zebrafish embryos. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.109754DOI Listing
December 2019
1 Read

Sustained delivery of olanzapine from sunflower oil-based polyol-urethane nanoparticles synthesised through a cyclic carbonate ring-opening reaction.

IET Nanobiotechnol 2019 Sep;13(7):703-711

Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran.

The forefront horizon of biomedical investigations in recent decades is parcelling-up and delivery of drugs to achieve controlled/targeted release. In this regard, developing green-based delivery systems for a spatiotemporal controlling therapeutic agent have drawn a lot of attention. A facile route based on cyclic carbonate ring-opening reaction has been utilised to synthesise a bio-based polyol-containing urethane bond [polyol-urethane (POU)] as a nanoparticulate drug delivery system of olanzapine in order to enhance its bioavailability. Read More

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http://dx.doi.org/10.1049/iet-nbt.2018.5440DOI Listing
September 2019
1 Read
1.500 Impact Factor

Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3β/β-catenin signaling pathway in the SH-SY5Y cell line.

Chem Biol Interact 2019 Dec 26;314:108823. Epub 2019 Sep 26.

Department of Pharmacology, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey. Electronic address:

Schizophrenia cannot be treated sufficiently with existing antipsychotic drugs. Taken into account that increased Glycogen Synthase Kinase 3 Beta (GSK-3β) activity is associated with schizophrenia pathophysiology and certain antipsychotics can be able to decrease GSK3β activity, inhibition of GSK-3β activity could be a novel approach for the treatment of schizophrenia. In the present study MK-801, a widely used chemical for the in vivo/in vitro modeling of schizophrenia was selected to evoke a detrimental effect on cellular survival via GSK3β and related proteins. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.108823DOI Listing
December 2019
3 Reads

Fluoxetine exposure disrupts food intake and energy storage in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes).

Chemosphere 2020 Jan 17;238:124609. Epub 2019 Aug 17.

CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Ecotoxicología Acuática, Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Argentina. Electronic address:

Human pharmaceuticals are pollutants of special concern due to their widespread consumption over the last decades, their high persistence in the environment, and the reported alterations produced on non-target organism. The antidepressant fluoxetine (FLX) exerts its effect by inhibiting serotonin (5-HT) reuptake at the presynaptic membrane, thus increasing brain serotonergic activity. In vertebrates, there is a clear inverse relationship between hypothalamic 5-HT levels and food intake, therefore we hypothesized that FLX would inhibit food intake, and in consequence alter energy metabolism in freshwater fish. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.124609DOI Listing
January 2020

Cortisol disruption and transgenerational alteration in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure.

Toxicol Appl Pharmacol 2019 11 30;382:114742. Epub 2019 Aug 30.

Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. Electronic address:

Fluoxetine (FLX), the active ingredient in well-known therapeutic drugs such as Prozac, is highly prescribed worldwide to treat affective disorders even among pregnant women and adolescents. Given that FLX readily crosses the placenta, a fetus from a treated pregnant woman is potentially at risk from unintended effects of the chemical. Moreover, FLX reaches aquatic ecosystems at biologically active levels through sewage release, so fish may also be inadvertently affected. Read More

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http://dx.doi.org/10.1016/j.taap.2019.114742DOI Listing
November 2019

A UPLC-MS/MS Assay for Simultaneous Determination of Two Antipsychotics and Two Antidepressants in Human Plasma and Its Application in Clinic.

Curr Pharm Biotechnol 2020 ;21(1):60-69

Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Antidepressants and antipsychotics are widely prescribed drugs for the treatment of mental diseases. Therapeutic drug monitoring (TDM) is recommended for patients taking these drugs to ensure pharmaceutical efficacy, medication compliance and prevent toxicity.

Objective: An ultra-high performance liquid chromatography/tandem-mass spectrometry (UPLC-MS/ MS) method was developed for simultaneous determination of two Antidepressants-Fluoxetine (FLU) and Escitalopram (ESC), and two antipsychotics-risperidone (RIS) and aripiprazole (ARI), in human plasma. Read More

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http://dx.doi.org/10.2174/1389201020666190830150549DOI Listing
March 2020
1 Read

Interactive Effects of Sertraline and Diphenhydramine on Biochemical and Behavioral Responses in Crucian Carp ().

Int J Environ Res Public Health 2019 08 28;16(17). Epub 2019 Aug 28.

Water Conservancy Project & Civil Engineering College, Tibet Agriculture & Animal Husbandry University, Linzhi 860000, China.

The ecotoxicity of psychiatric pharmaceuticals to aquatic organisms is being increasingly recognized. However, current ecological studies focus on the effects of individual psychiatric pharmaceuticals, with little attention being given to their combined effects. In this study, the interactive effects of two psychiatric pharmaceuticals, sertraline (SER) and diphenhydramine (DPH), on bioconcentration and biochemical and behavioral responses were investigated in crucian carp () after seven days of exposure. Read More

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http://dx.doi.org/10.3390/ijerph16173137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747225PMC
August 2019
1 Read

Analysis of neurotransmitters in Daphnia magna affected by neuroactive pharmaceuticals using liquid chromatography-high resolution mass spectrometry.

Environ Pollut 2019 Nov 8;254(Pt B):113029. Epub 2019 Aug 8.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Catalonia, Spain.

Neurotransmission plays an essential role during the central nervous system (CNS) development. During the last years, several studies based on the changes produced in neurotransmitters of aquatic organisms caused by pharmaceuticals have been reported. Daphnia magna, the aquatic ecotoxicological model organism, shares several of the neurotransmitters targeted by antidepressant and other neuro-active drugs with vertebrates. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113029DOI Listing
November 2019

Up-regulation of hepatic fatty acid transporters and inhibition/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis.

Toxicol Lett 2019 Nov 19;316:183-193. Epub 2019 Aug 19.

Institute of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Olanzapine, a representative of antipsychotics, is a first-line drug for treatment of schizophrenia. However, olanzapine-induced liver steatosis limits its clinical utilization. This study is to explore the mechanism of liver steatosis induced by olanzapine based on the regulation of transporters involved in uptake and oxidation of fatty acids. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.08.013DOI Listing
November 2019
6 Reads

The preventive role of wheat germ oil against sertraline-induced testicular damage in male albino rats.

Authors:
Hamida Hamdi

Andrologia 2019 Nov 16;51(10):e13369. Epub 2019 Aug 16.

Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.

Sertraline is an antidepressant medication used extensively in the therapy of depression. The present investigation was intended to estimate the actual protective role of wheat germ oil on sertraline-caused testicular injury in albino rats. Sertraline (human therapeutic dose, 15. Read More

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http://dx.doi.org/10.1111/and.13369DOI Listing
November 2019

The Psychoactive Drug Escitalopram Affects Foraging Behavior in Zebrafish (Danio rerio).

Environ Toxicol Chem 2019 09 6;38(9):1902-1910. Epub 2019 Aug 6.

Zoophysiology Research, Department of Bioscience, Aarhus University, Aarhus, Denmark.

Selective serotonin reuptake inhibitors (SSRIs) are psychoactive pharmaceuticals that have been detected intact in natural waters globally. Laboratory experiments have reported that several SSRIs inhibit fish foraging behavior, but data for the SSRI escitalopram are lacking. The objectives of the present study were to determine whether escitalopram affects feeding behavior in zebrafish and whether possible sex differences exist. Read More

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http://dx.doi.org/10.1002/etc.4474DOI Listing
September 2019

Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex.

Front Pharmacol 2019 17;10:804. Epub 2019 Jul 17.

Laboratorio de Neurociencias, Universidad de los Andes, Santiago, Chile.

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat mood and anxiety disorders. Chronic treatment with this antidepressant drug is thought to favor functional recovery by promoting structural and molecular changes in several forebrain areas. At the synaptic level, chronic fluoxetine induces an increased size and density of dendritic spines and an increased ratio of GluN2A over GluN2B N-methyl-D-aspartate (NMDA) receptor subunits. Read More

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http://dx.doi.org/10.3389/fphar.2019.00804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650542PMC
July 2019
3 Reads

Does the antidepressant sertraline show chronic effects on aquatic invertebrates at environmentally relevant concentrations? A case study with the keystone amphipod, Gammarus locusta.

Ecotoxicol Environ Saf 2019 Nov 1;183:109486. Epub 2019 Aug 1.

CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto. Avenida General Norton de Matos S/N, 4450-208, Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre nº 1021/1055, 4169-007, Porto, Portugal. Electronic address:

The increasing use of Sertraline (SER) as antidepressant and its consequent presence in the aquatic environment is raising concern about the chronic effects of this pharmaceutical to aquatic organisms. As the current concentrations of SER in surface waters are typically in the low ng/L range, acute toxicity is unlikely to occur. However, prolonged exposure to low concentrations of SER may lead to sub-lethal effects in aquatic organisms, including alterations in important physiological functions like growth, reproduction, behaviour, and also in key biochemical processes, such as those associated with neurotransmission and redox balance. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.109486DOI Listing
November 2019
2 Reads

Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats.

Andrologia 2019 Oct 26;51(9):e13371. Epub 2019 Jul 26.

Functional Foods and Nutraceuticals Unit, Biochemistry Department, Federal University of Technology, Akure, Nigeria.

In comparison to other antidepressant drugs, erectile dysfunction (ED) is more pronounced in paroxetine use. On the other hand, orange (Citrus sinensis) peels commonly consumed in various forms are used in folkloric medicine for ED management. Thus, this study evaluated the effect of orange peels infusion on sexual behaviour, nitric oxide (NO) level and some enzymes (arginase, phosphodiesterase-5 [PDE-5], acetylcholinesterase [AChE] and adenosine deaminase [ADA]) in paroxetine-treated rats. Read More

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http://dx.doi.org/10.1111/and.13371DOI Listing
October 2019
1 Read

Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial.

Lancet Infect Dis 2019 08;19(8):843-851

Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA.

Background: Identifying new antifungals for cryptococcal meningitis is a priority given the inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity against cryptococcus. We aimed to assess the efficacy and cost-effectiveness of adjunctive sertraline in adults with HIV-associated cryptococcal meningitis compared with placebo. Read More

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http://dx.doi.org/10.1016/S1473-3099(19)30127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041360PMC
August 2019
10 Reads
22.433 Impact Factor

Syntheses of Benzo[]Thiazol-2(3)-One Derivatives and Their Antidepressant and Anticonvulsant Effects.

Mar Drugs 2019 Jul 23;17(7). Epub 2019 Jul 23.

College of Medicine, Jiaxing University, Jiaxing 314001, China.

Thirty-four new benzo[]thiazol derivatives -, -, and - were synthesized and investigated for their potential antidepressant and anticonvulsant effects. In a forced swimming test, and showed the highest antidepressant and anticonvulsant effects. and displayed a higher percentage decrease in immobility duration (89. Read More

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http://dx.doi.org/10.3390/md17070430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669756PMC

Is there any potential anticancer effect of raloxifene and fluoxetine on DMBA-induced rat breast cancer?

J Biochem Mol Toxicol 2019 Sep 23;33(9):e22371. Epub 2019 Jul 23.

Department of Medical Pathology, Faculty of Medicine, Firat University, Elazıg, Turkey.

Breast cancer is the most common cancer among women in the world and the incidence is increasing alarmingly. It was aimed to determine the effect of raloxifene (RAL) and fluoxetine (FLX) on selected parameters in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma. Thirty-two female Wistar albino rats were assorted into four groups: DMBA (group I), DMBA+RAL (group II), DMBA+FLX (group III), and DMBA+RAL+FLX (group IV). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22371
Publisher Site
http://dx.doi.org/10.1002/jbt.22371DOI Listing
September 2019
21 Reads

Effect of Pregnancy on Paroxetine-Induced Adiposity and Glucose Intolerance in Mice.

J Pharmacol Exp Ther 2019 10 15;371(1):113-120. Epub 2019 Jul 15.

Departments of Pharmaceutics (W.Z., T.H., J.W.), Pharmacy (M.F.H.), and Obstetrics and Gynecology (M.F.H.), University of Washington, Seattle, Washington

Long-term use of selective serotonin reuptake inhibitors (SSRIs) targeting the serotonin transporter (SERT) has been suggested to be associated with an increased risk for obesity and type 2 diabetes. Previously, using a murine knockout model of SERT, we showed that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance in nonpregnant mice. The present study investigated the effects of chronic paroxetine treatment on adiposity and glucose tolerance in mice before and during pregnancy. Read More

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http://dx.doi.org/10.1124/jpet.118.255380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750187PMC
October 2019
1 Read

Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies.

Apoptosis 2019 10;24(9-10):773-784

Department of Animal Physiology and Reproduction, Faculty of Biotechnology, University of Rzeszow, Werynia 502, 36-100, Kolbuszowa, Poland.

Depression is a serious medical condition, typically treated by antidepressants. Conventional monotherapy can be effective only in 60-80% of patients, thus modern psychiatry deals with the challenge of new methods development. At the same moment, interactions between antidepressants and the occurrence of potential side effects raise serious concerns, which are even more exacerbated by the lack of relevant data on exact molecular mechanisms. Read More

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http://dx.doi.org/10.1007/s10495-019-01557-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711955PMC
October 2019
1 Read

Citalopram overdose and severe serotonin syndrome in an intermediate metabolizing patient.

Am J Emerg Med 2019 10 21;37(10):1993.e5-1993.e6. Epub 2019 Jun 21.

Department of Emergency Medicine, University of Rochester Medical Center, 601 Elmwood Ave. Box 655, Rochester, NY 14642, United States of America.

Introduction: Citalopram is a selective serotonin reuptake inhibitor used for treatment of depression. Metabolism is primarily through CYP3A4 and CYP2C19; activity of the latter can vary depending on genetics. Although rare after single agent exposure, large citalopram ingestions can lead to serotonin syndrome. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.06.038DOI Listing
October 2019
4 Reads

Clinical Toxicology and Overdose of Psychiatric Medications.

Authors:
Y C Chan

East Asian Arch Psychiatry 2019 Jun;29(2):57-62

Accident & Emergency Department, Hong Kong Poison Information Centre, United Christian Hospital, Hong Kong.

This article reviews the poisoning epidemiology in Hong Kong, assessment and treatment of acute poisoning, and management of acute psychiatric medication overdose. In 2016, nearly 4000 poisoning cases involving approximately 6000 poisons were reported to Hong Kong Poison Information Centre. About 25% of the poisons involved were psychiatric-related medications. Read More

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June 2019
10 Reads

Environmentally relevant concentrations of methamphetamine and sertraline modify the behavior and life history traits of an aquatic invertebrate.

Aquat Toxicol 2019 Aug 11;213:105222. Epub 2019 Jun 11.

University of South Bohemia in České Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.

Pharmaceutically active compounds are major contaminants of aquatic environments that show direct and indirect effects on aquatic organisms even at low concentrations. The aim of this study was to assess the effects of the illicit drug methamphetamine and the antidepressant sertraline on clonal marbled crayfish Procambarus virginalis. Crayfish exposed to the environmentally relevant concentrations of methamphetamine of ∼1 μg L did not exhibit significant differences from unexposed controls in distance moved, velocity, and activity level with or without available shelter. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.105222DOI Listing
August 2019
5 Reads

Exposures Through Breast Milk: An Analysis of Exposure and Information Calls to U.S. Poison Centers, 2001-2017.

Breastfeed Med 2019 09 18;14(7):508-512. Epub 2019 Jun 18.

Department of Emergency Medicine/Oregon, Alaska and Guam Poison Center, Oregon Health and Science University, Portland, Oregon.

We described calls to U.S. poison centers (PCs) related to potential exposure to substances through breast milk. Read More

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http://dx.doi.org/10.1089/bfm.2019.0075DOI Listing
September 2019
9 Reads

Mutagenicity and recombinogenicity evaluation of bupropion hydrochloride and trazodone hydrochloride in somatic cells of Drosophila melanogaster.

Food Chem Toxicol 2019 Sep 7;131:110557. Epub 2019 Jun 7.

Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Umuarama, 38400-902, Uberlândia, Minas Gerais, Brazil; Institute of Exact and Natural Sciences of Pontal, Federal University of Uberlândia, Campus Pontal, 38304-402, Ituiutaba, Minas Gerais, Brazil. Electronic address:

The aim of the present study was to appraise the mutagenic and recombinogenic potential of bupropion hydrochloride (BHc) and trazodone hydrochloride (THc). We used standard (ST) and the high bioactivation (HB) crossings from Drosophila melanogaster in the Somatic Mutation and Recombination Test. We treated third-instar larvae from both crossings with different concentrations of BHc and THc (0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.06.004DOI Listing
September 2019
4 Reads

Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.

Circ Res 2019 08 3;125(4):449-466. Epub 2019 Jun 3.

From the Pulmonary Hypertension Research Group of the Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Laval University, Québec City, Canada (B.R., V.N., A.B., S.P., E.T., J.O., N.C., R.A-A., L.T., A.D., S.B.-B., P.P., R.P., O.B., S.B., F.P.).

Rationale: Pulmonary hypertension (PH) due to left heart disease (LHD), or group 2 PH, is the most prevalent form of PH worldwide. PH due to LHD is often associated with metabolic syndrome (MetS). In 12% to 13% of cases, patients with PH due to LHD display vascular remodeling of pulmonary arteries (PAs) associated with poor prognosis. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314555DOI Listing
August 2019
32 Reads

Fluoxetine suppresses the immune responses of blood clams by reducing haemocyte viability, disturbing signal transduction and imposing physiological stress.

Sci Total Environ 2019 Sep 22;683:681-689. Epub 2019 May 22.

College of Animal Sciences, Zhejiang University, Hangzhou, PR China. Electronic address:

The antidepressant fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widely prescribed for the treatment of depression and anxiety disorders. Nowadays, measurable quantities of FLX have been frequently detected in the aquatic ecosystems worldwide, which may pose a potential threat to aquatic organisms. Although the impacts of FLX exposure on immune responses are increasingly well documented in mammals, they remain poorly understood in aquatic invertebrates. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.05.308DOI Listing
September 2019
11 Reads

Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats.

Neuropharmacology 2019 09 22;155:104-112. Epub 2019 May 22.

Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071, Málaga, Spain. Electronic address:

Galanin (1-15) [GAL(1-15)] participates in mood regulation and depression. GAL(1-15) is also able to enhance the antidepressant effects induced by Fluoxetine (FLX) in the forced swimming test through interaction between GALR1-GALR2 and 5-HT1A receptors that induced changes in the binding characteristics and mRNA of the 5-HT1AR in the hippocampus. Since the medial prefrontal cortex (mPFC) is a core region for the interaction between emotional processing and cognition with a high density of 5-HT1AR and GALR1 and GALR2, we have analyzed the binding characteristics and mRNA levels of 5-HT1AR in the mPFC after GAL(1-15)-FLX administration in the rats. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.05.023DOI Listing
September 2019
7 Reads

CNTs coated charcoal as a hybrid composite material: Adsorption of fluoxetine probed by zebrafish embryos and its potential for environmental remediation.

Chemosphere 2019 Sep 10;230:369-376. Epub 2019 May 10.

Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética & Morfologia, Brasília, DF, Brazil.

Although traditional water treatment systems can remove various substances from wastewater, these conventional systems fail to remove many chemical molecules that pose potential ecological and health risks. Carbon nanotubes (CNTs) appear attractive to adsorption of many substances, but CNTs adsorbed with toxic substances becomes a nanocomposite still more toxic. Here, we employ zebrafish embryos as biosensor to examine how a hybrid micro/nanostructured carbonaceous material (HMNC) derived from a combination of activated carbon (AC) with hydrophilic carbon nanotubes (CNTs) can remediate wastewater contaminated with the pharmaceutical fluoxetine hydrochloride (FLX). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.05.019DOI Listing
September 2019
8 Reads

An atypical case of serotonin syndrome with normal dose of selective serotonin inhibitors: A case report.

Medicine (Baltimore) 2019 May;98(19):e15554

Department of Emergency.

Rationale: As increasing frequency of serotonergic drug use, SS (serotonin syndrome) occurred more than ever. But clinicians have not enough knowledge and experience about SS as a potentially life-threatening condition. SS is usually caused by the increased serotonin activity in the central nervous system which may due to a serotonergic agent overdose or the concomitant use of 2 or more serotonergic antidepressants. Read More

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http://dx.doi.org/10.1097/MD.0000000000015554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531198PMC
May 2019
7 Reads

Effects of methylphenidate on the aggressive behavior, serotonin and dopamine levels, and dopamine-related gene transcription in brain of male Nile tilapia (Oreochromis niloticus).

Fish Physiol Biochem 2019 Aug 3;45(4):1377-1391. Epub 2019 May 3.

Department of Natural Sciences, FURB Fundação Universidade Regional de Blumenau, Blumenau, SC, Brazil.

The occurrence of pharmaceuticals in the aquatic environment has increased considerably in the last decades, causing negative biochemical, physiological, and behavioral effects in aquatic organisms. In this study, we evaluated the effects of methylphenidate (MPH) on the aggressive behavior, dopamine-related gene transcript levels, monoamine levels, and carboxylesterase transcript levels and activity in the brain of male Nile tilapia (Oreochromis niloticus). Carboxylesterase activity was also measured in the liver and gills. Read More

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http://dx.doi.org/10.1007/s10695-019-00645-2DOI Listing
August 2019
4 Reads

A Case Report of Serotonin Syndrome in a Patient on Selective Serotonin Reuptake Inhibitor (SSRI) Monotherapy.

J Pharm Pract 2020 Apr 28;33(2):206-212. Epub 2019 Apr 28.

Pharmacy Practice, MCPHS University, Boston, MA, USA.

Introduction: Paroxetine is a selective serotonin reuptake inhibitor (SSRI) with several indications, one of which is for depression. We present a case of probable paroxetine-induced serotonin syndrome.

Case Summary: A 21-year-old female with a history of generalized anxiety disorder and major depression presented with increased depressive symptoms over several months while taking fluoxetine 20 mg daily. Read More

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http://dx.doi.org/10.1177/0897190019841742DOI Listing
April 2020
8 Reads

Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal.

J Glob Oncol 2019 04;5:1-6

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.

Purpose: The purpose of the study was to compare efficacy and toxicity of olanzapine (OLN; a higher-cost drug) and haloperidol (HAL; a lower-cost drug) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC).

Patients And Methods: In a randomized, phase II trial, patients were randomly assigned to receive either OLN 10 mg orally on days 1 to 4 or HAL 1 mg orally on day 1 and 0.5 mg twice daily on days 2 to 4. Read More

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http://dx.doi.org/10.1200/JGO.18.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528728PMC
April 2019
3 Reads

Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).

Toxicology 2019 06 19;422:69-75. Epub 2019 Apr 19.

Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

Many psychoactive substances affect the human dopamine (DA) reuptake transporter (hDAT). Polymorphisms in the encoding gene could affect the functionality of the transporter and consequently alter effects of psychotropic and recreational drugs. Recently, a T356 M single nucleotide polymorphism in the human SLC6A3 gene was described, which resulted in functional impairments of DA uptake. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.012DOI Listing
June 2019
15 Reads