6,543 results match your criteria Toxicity Sedative-Hypnotics


Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae.

An Acad Bras Cienc 2020 17;92(1):e20180595. Epub 2020 Apr 17.

Instituto de Ciências do Mar/LABOMAR, Universidade Federal do Ceará, Av. da Abolição 3207, Bairro Meireles, 60165-081 Fortaleza, CE, Brazil.

Pharmaceuticals occur in the environment due to their excessive consumption and the inefficiency of treatment plants to degrade, inactivate or remove them. Diazepam (DZP) stands out as the most consumed benzodiazepine, and induces sedative effects and reduces anxiety. Considering its potential appearance in several environmental compartments, the aim of the present study was to determine the effects of DZP under acute and chronic exposures on the mysid Mysidopsis juniae. Read More

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http://dx.doi.org/10.1590/0001-3765202020180595DOI Listing

Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA currents, but are not neurotoxic to the developing rat brain.

Br J Anaesth 2020 05 6;124(5):603-613. Epub 2020 Mar 6.

Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

Background: The most currently used general anaesthetics are potent potentiators of γ-aminobutyric acid A (GABA) receptors and are invariably neurotoxic during the early stages of brain development in preclinical animal models. As causality between GABA potentiation and anaesthetic-induced developmental neurotoxicity has not been established, the question remains whether GABAergic activity is crucial for promoting/enhancing neurotoxicity. Using the neurosteroid analogue, (3α,5α)-3-hydroxy-13,24-cyclo-18,21-dinorchol-22-en-24-ol (CDNC24), which potentiates recombinant GABA receptors, we examined whether this potentiation is the driving force in inducing neurotoxicity during development. Read More

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http://dx.doi.org/10.1016/j.bja.2020.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222221PMC

Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks.

Toxicol Lett 2020 Apr 16;322:98-103. Epub 2020 Jan 16.

Experimental Anesthesiology Section, Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls-University, Waldhoernlestrasse 22, 72072, Tuebingen, Germany. Electronic address:

Patients intoxicated with organophosphorous compounds may need general anaesthesia to enable mechanical ventilation or for control of epileptiform seizures. It is well known that cholinergic overstimulation attenuates the efficacy of general anaesthetics to reduce spontaneous network activity in the cortex. However, it is not clear how propofol, the most frequently used intravenous anaesthetic today, is affected. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.01.012DOI Listing
April 2020
3.262 Impact Factor

Daphne giraldii Nitsche (Thymelaeaceae): Phytochemistry, pharmacology and medicinal uses.

Phytochemistry 2020 Mar 31;171:112231. Epub 2019 Dec 31.

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address:

Daphne giraldii Nitsche., a member of the genus Daphne (Thymelaeaceae), is a deciduous shrub with mild toxicity. Its rhizome bark, generally called 'Zushima' in Chinese, has many medicinal folkloric uses and good therapeutic effects. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.112231DOI Listing

Analgesic, anti-inflammatory and sedative/hypnotic effects of Icaritin, and its effect on chloride influx in mouse brain cortical cells.

Cell Mol Biol (Noisy-le-grand) 2019 Sep 30;65(7):99-104. Epub 2019 Sep 30.

Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University, China.

Inflammation and insomnia are medical problems that may severely affect work and health, thereby necessitating strategies for their effective treatment. Icartin (ICT) is a major active monomeric component of icariin  . Studies have revealed that ICT possesses several pharmacological properties such anti-inflammatory, anti-tumor, anti-fibrotic, anti-osteoporotic and neuroprotective effects. Read More

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September 2019

The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis.

Authors:
Helmut K Seitz

Chem Biol Interact 2020 Jan 11;316:108918. Epub 2019 Dec 11.

Centre of Alcohol Research (CAR), University of Heidelberg, Heidelberg and Department of Medicine, Salem Medical Centre, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.108918DOI Listing
January 2020

The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity.

Drug Des Devel Ther 2019 14;13:3887-3898. Epub 2019 Nov 14.

Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Purpose: Dexmedetomidine [DEX; (S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole] is a selective α-adrenergic receptor (α-AR) agonist that attenuates the liver damage associated with local or systemic inflammation. However, it remains unclear whether DEX has protective effects against acetaminophen (Paracetamol, PARA)-induced liver toxicity (PILT).

Methods: PILT mice were established by intraperitoneal administration of a hepatotoxic dose of acetaminophen (300 mg/kg). Read More

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http://dx.doi.org/10.2147/DDDT.S215473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861533PMC

Dexmedetomidine prevents desflurane-induced motor neuron death through NF-KappaB pathway.

Cell Biochem Funct 2020 Jan 27;38(1):21-27. Epub 2019 Nov 27.

Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China.

Desflurane is one of the commonly used general anaesthetics. Recently, it was reported that desflurane caused neurotoxicity, raising concerns in clinical use. In this study, we found desflurane could affect viability and maturation in motor neurons. Read More

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http://dx.doi.org/10.1002/cbf.3439DOI Listing
January 2020

Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved.

BMC Pharmacol Toxicol 2019 11 21;20(1):70. Epub 2019 Nov 21.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai village, Nanbaixiang town, Ouhai District, Wenzhou City, 325000, Zhejiang Province, China.

Background: Dexmedetomidine was proved to mitigate bupivacaine-induced cardiotoxicity but mechanism of this ability is still unclear. This study was designed to investigate the direct effects of dexmedetomidine on cardiotoxicity induced by bupivacaine on Langendorff rat heart preparation and the role of alpha 2 adrenoceptors in this process was explored.

Methods: Hearts of rat were isolated, mounted on a Langendorff system. Read More

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http://dx.doi.org/10.1186/s40360-019-0371-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873694PMC
November 2019

Bioconcentration and behavioral effects of four benzodiazepines and their environmentally relevant mixture in wild fish.

Sci Total Environ 2020 Feb 2;702:134780. Epub 2019 Nov 2.

Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.

We studied the adverse effects of four benzodiazepines frequently measured in European surface waters. We evaluated bioaccumulation potential of oxazepam, bromazepam, temazepam, and clobazam in freshwater fish species - perch (Perca fluviatilis) and we conducted a series of behavioral trials to assess their potential to alter boldness, activity, and social behavior. All selected endpoints were studied individually for each target benzodiazepine and as a mixture of all tested compounds to assess possible combinatory effects. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.134780DOI Listing
February 2020

Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABA receptors.

Bioorg Chem 2020 Jan 12;94:103334. Epub 2019 Oct 12.

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russia. Electronic address:

Structure-activity relationship studies were conducted in the search for 1,3-thiazole isosteric analogs of imidazopyridine drugs (Zolpidem, Alpidem). Three series of novel γ-aminobutyric acid receptor (GABAR) ligands belonging to imidazo[2,1-b]thiazoles, imidazo[2,1-b][1,3,4]thiadiazoles, and benzo[d]imidazo[2,1-b]thiazoles were synthesized and characterized as active agents against GABAR benzodiazepine-binding site. In each of these series, potent compounds were discovered using a radioligand competition binding assay. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.103334DOI Listing
January 2020

MicroRNA-665 mediates propofol-induced cell apoptosis in human stem cell-derived neurons.

Bioengineered 2019 12;10(1):493-500

Department of Anesthesia, the Affiliated Hospital of Qingdao University , Qingdao , Shandong , China.

We aimed to evaluate the neurotoxicity and mechanisms of anesthetics propofol in hESC-derived neurons. Cell apoptosis in hESC-derived neurons' exposure to 4, 10 and 20 μg/mL propofol for 6 h was assessed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate in situ nick end labeling (TUNEL) staining and microRNA-665 (miR-665) expression was assessed using quantitative reverse transcription polymerase chain reaction (qRT-PCR). miR-665 was overexpressed and knocked down using a miR-665 mimic and anti-665 transfection, respectively. Read More

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http://dx.doi.org/10.1080/21655979.2019.1682105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844390PMC
December 2019

Successful treatment of a severe cannabinoid toxicity using extracorporeal therapy in a dog.

J Vet Emerg Crit Care (San Antonio) 2019 Nov 22;29(6):674-679. Epub 2019 Oct 22.

Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina.

Objective: To describe the use of extracorporeal therapy (ECT) to treat severe cannabinoid intoxication in a dog with severe hyperlipidemia.

Case Summary: A 7-month-old female intact Labrador Retriever presented with seizures and severe hyperesthesia that were refractory to multiple anticonvulsant medications and required induction of general anesthesia with propofol and mechanical ventilation. The dog's urine yielded a strong positive signal for delta-9-tetrahydrocannabinol (THC) on urine drug test and exposure to THC oil was confirmed by the owner. Read More

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http://dx.doi.org/10.1111/vec.12899DOI Listing
November 2019

Acute kidney injury, seizures, and hypertonic hyponatremia secondary to mannitol intoxication in a dog.

J Vet Emerg Crit Care (San Antonio) 2019 Nov 21;29(6):680-685. Epub 2019 Oct 21.

Unité Urgences et soins intensifs, Ecole Nationale Vétérinaire de Toulouse, Toulouse Cedex 03, France.

Objective: To describe a case of mannitol overdose associated with acute kidney injury (AKI), hypertonic hyponatremia, and neurologic abnormalities in a dog.

Case Summary: A 10-year-old intact male Shiba Inu dog was referred to the emergency service of a veterinary teaching hospital for inappetence and acute onset of seizures. The dog had received 2 IV boluses of 3 g/kg of mannitol in less than 24 hours for a glaucoma crisis. Read More

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http://dx.doi.org/10.1111/vec.12902DOI Listing
November 2019
1 Read

Primary cilia respond to intermittent low-magnitude, high-frequency vibration and mediate vibration-induced effects in osteoblasts.

Am J Physiol Cell Physiol 2020 01 2;318(1):C73-C82. Epub 2019 Oct 2.

Department of Orthopedic Trauma, The First Hospital of Jilin University, Changchun, China.

Our objective was to investigate the role of primary cilia in low-magnitude, high-frequency vibration (LMHFV) treatment of MC3T3-E1 osteoblasts (OBs). We used chloral hydrate (CH), which has a well-characterized function in chemically removing primary cilia, to elucidate the role of primary cilia in LMHFV-induced OB osteogenic responses through cell viability assay, Western blot analysis, real-time quantitative RT-PCR, and histochemical staining methods. We observed a significant, 30% decrease in the number of MC3T3-E1 OBs with primary cilia (reduced from 64. Read More

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https://www.physiology.org/doi/10.1152/ajpcell.00273.2019
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http://dx.doi.org/10.1152/ajpcell.00273.2019DOI Listing
January 2020
1 Read

The Effects of Agomelatine on The Biochemical and Pathological Features of Cisplatin-Induced Peripheral Neuropathy: The First Experimental Study in Rats.

Turk Neurosurg 2019 ;29(6):901-908

Adiyaman University School of Medicine, Department of Neurosurgery, Adiyaman, Turkey.

Aim: To evaluate the effects of agomelatine on the biochemical and pathological features of cisplatin-induced peripheral neuropathy.

Material And Methods: This study included a total of 30 male Wistar albino rats that weighed 285â€"300 grams and were divided into three groups: healthy controls (HC, n=10); cisplatin group (CIS, n=10) and agomelatine plus cisplatin group (AC, n=10). The CIS group received only cisplatin (EbeweLiba, Turkey) at a dose of 2. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.26589-19.2DOI Listing
February 2020

Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer.

Drug Des Devel Ther 2019 18;13:3307-3319. Epub 2019 Sep 18.

Department of Anesthesiology, Jinan Central Hospital Affiliated to Shandong University, Ji'nan, Shandong Province 250013, People's Republic of China.

Purpose: Hyaluronic acid-poly(ethylene glycol)-distearoyl phosphoethanolamine (HA-PEG-DSPE) modified and tocopheryl polyethylene glycol 1000 succinate (TPGS) contained nanostructured lipid carriers (NLCs) were prepared loading ropivacaine and dexmedetomidine to improve the topical anesthetic analgesic anesthesia efficiency.

Methods: NLCs were prepared by the solvent diffusion method. The average particle size, zeta potential, release behavior, and cytotoxicity of the NLCs were tested. Read More

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http://dx.doi.org/10.2147/DDDT.S211443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755955PMC
February 2020
6 Reads

Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS.

Chin J Nat Med 2019 Jul;17(7):551-560

Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China. Electronic address:

Ziziphi Spinosae Semen (ZSS) has been used for treatment of insomnia in China for centuries. To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (GABA), noradrenaline (NE) and dopamine (DA), and to study the role of ZSS aqueous extract in the treatment of insomnia, an UPLC-ESI- MS/MS method was developed and validated for simultaneous determination of five neurotransmitters in the rat brain. The brain samples were pretreated by one-step direct protein precipitation with acetonitrile. Read More

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http://dx.doi.org/10.1016/S1875-5364(19)30077-9DOI Listing
July 2019
8 Reads

Dexmedetomidine attenuates the induction and reverses the progress of 6-hydroxydopamine- induced parkinsonism; involvement of K channels, alpha 2 adrenoceptors and anti-inflammatory mechanisms.

Toxicol Appl Pharmacol 2019 11 30;382:114743. Epub 2019 Aug 30.

Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Background: Studies have shown that dexmedetomidine (DEX), a potent α-adrenoceptors agonist provides neuroprotection through suppression of inflammatory response. In present study, we examined effect of DEX and its underlying mechanisms on the induction and progress of 6-OHDA- induced Parkinsonism in rat.

Material And Methods: The 6-OHDA was injected into the medial forebrain bundle of right hemisphere by stereotaxic surgery and then, behavioral tests carried out within second, fourth, sixth and eighth weeks post-surgery. Read More

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http://dx.doi.org/10.1016/j.taap.2019.114743DOI Listing
November 2019

Interactive Effects of Sertraline and Diphenhydramine on Biochemical and Behavioral Responses in Crucian Carp ().

Int J Environ Res Public Health 2019 08 28;16(17). Epub 2019 Aug 28.

Water Conservancy Project & Civil Engineering College, Tibet Agriculture & Animal Husbandry University, Linzhi 860000, China.

The ecotoxicity of psychiatric pharmaceuticals to aquatic organisms is being increasingly recognized. However, current ecological studies focus on the effects of individual psychiatric pharmaceuticals, with little attention being given to their combined effects. In this study, the interactive effects of two psychiatric pharmaceuticals, sertraline (SER) and diphenhydramine (DPH), on bioconcentration and biochemical and behavioral responses were investigated in crucian carp () after seven days of exposure. Read More

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http://dx.doi.org/10.3390/ijerph16173137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747225PMC
August 2019
1 Read

New insights and rethinking of cinnabar for chemical and its pharmacological dynamics.

Bioengineered 2019 12;10(1):353-364

Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Guizhou , China.

Cinnabar is an attractive mineral with many different uses. It is reported that cinnabar is one of the traditional Chinese's medicines extensively use. The main objective of this critical review is to identify the current overview, concept and chemistry of cinnabar, which includes the process developments, challenges, and diverse options for pharmacology research. Read More

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http://dx.doi.org/10.1080/21655979.2019.1652491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738451PMC
December 2019
4 Reads

Propofol reduces acute lung injury by up-regulating gamma-aminobutyric acid type a receptors.

Exp Mol Pathol 2019 10 13;110:104295. Epub 2019 Aug 13.

Department of Anesthesiology, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, PR China. Electronic address:

Background: We used a two-hit lung injury rat model that involves mechanical ventilation (MV) following lipopolysaccharide exposure to investigate the effects of propofol on the expression of GABA receptors (GABAR) and cytokine responses, and we then determined the specific effects of GABA on cytokine responses in vitro in alveolar epithelial cells (AECs).

Methods: Forty-eight adult male Wister rats were equally and randomly divided into the following 4 groups (n = 12) using a random number table: sham group, sham+propofol group, lipopolysaccharide (LPS) + VILI group, and LPS + VILI + propofol group. All animals were anesthetized, and the animals received a 3. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.104295DOI Listing
October 2019
3 Reads

Atropine toxicity caused by erroneous intranasal administration in a pediatric patient: case report.

Ann Saudi Med 2019 Jul-Aug;39(4):279-282. Epub 2019 Aug 5.

From the Department of Surgery, Division of Otorhinolaryngology-Head and Neck Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

A 28-month-old boy mistakenly received intranasal atropine sulfate instead of Otrivin (xylometazoline hydrochloride) for the treatment of adenoid hypertrophy. Later on, he came to the emergency department with anticholinergic manifestations after the administration of multiple drops. The child presented with a tonic-clonic seizure lasting for a few minutes, followed by a brief loss of consciousness, vomiting, agitation, and irritability, all of which were stabilized by a dose of intravenous lorazepam. Read More

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http://dx.doi.org/10.5144/0256-4947.2019.279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838643PMC
January 2020
2 Reads

Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.

Neurotoxicology 2019 09 27;74:203-208. Epub 2019 Jul 27.

Neuroscience Branch, US Army Medical Research Institute of Chemical Defense, 8350 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010, USA.

Risk exists for civilian exposure to nerve agents (NA), and exposure can produce prolonged seizures. Pediatric populations are at greater risk for injury or death due to the central nervous system effects of NAs. To address the need to evaluate the effectiveness of anticonvulsants, pediatric and adult animal models were established to test the effectiveness of anticonvulsant drugs for treating NA-induced seizures in pediatric populations. Read More

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http://dx.doi.org/10.1016/j.neuro.2019.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871769PMC
September 2019
3 Reads

The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats.

J Toxicol Sci 2019 ;44(7):459-469

Laboratory of Animal Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University.

Phenobarbital (PB) and Di (2-ethylhexyl) phthalate (DEHP), an anti-epileptic drug and a plasticizer used in flexible polyvinylchloride formulations, respectively, are well-known typical hepatotoxicants. This study investigated the effects of PB (100 mg/kg/day) or DEHP (500 mg/kg/day) on the endocrine system in intact juvenile/peripubertal male rats exposed for 31 days beginning on postnatal day 23. Slight hormone level changes, histopathological changes in thyroid gland or induction of UDP-glucuronosyltransferase in liver were observed in both the PB and DEHP groups. Read More

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http://dx.doi.org/10.2131/jts.44.459DOI Listing
November 2019
1 Read

Potential role of the cAMP/PKA/CREB signalling pathway in hypoxic preconditioning and effect on propofol‑induced neurotoxicity in the hippocampus of neonatal rats.

Mol Med Rep 2019 Aug 19;20(2):1837-1845. Epub 2019 Jun 19.

Department of Anaesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

Hypoxic preconditioning (HPC) is neuroprotective against ischaemic brain injury; however, the roles of potential anti‑apoptotic signals in this process have not been assessed. To elucidate the molecular mechanisms involved in HPC‑induced neuroprotection, the effects of HPC on the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element‑binding protein (CREB) signalling pathway and apoptosis in Sprague‑Dawley pups (postnatal day 7) treated with propofol were investigated. Western blot and histological analyses demonstrated that HPC exerts multiple effects on the hippocampus, including the upregulation of cAMP and phosphorylation of CREB. Read More

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http://dx.doi.org/10.3892/mmr.2019.10397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625379PMC
August 2019
3 Reads
1.484 Impact Factor

Overexpression of phosphoprotein enriched in astrocytes 15 reverses the damage induced by propofol in hippocampal neurons.

Mol Med Rep 2019 Aug 21;20(2):1583-1592. Epub 2019 Jun 21.

Department of Anesthesiology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.

Propofol is a general anesthetic used in surgical operations. Phosphoprotein enriched in astrocytes 15(PEA15) was initially identified in astrocytes. The present study examined the role of PEA15 in the damage induced by propofol in hippocampal neurons. Read More

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http://dx.doi.org/10.3892/mmr.2019.10412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625386PMC
August 2019
4 Reads

Testing for midazolam and oxycodone in blood after formalin-embalmment: About a complex medico-legal case.

Drug Test Anal 2019 Sep 9;11(9):1460-1464. Epub 2019 Jul 9.

Institut de médecine légale, Strasbourg, France.

The stability of compounds in formalin solution is an important factor for drug analysis in a toxicological investigation. In this article, the authors report a complex medico-legal case involving midazolam and oxycodone. The complexity of this case comes from the fact that the body was embalmed with formalin solution before the autopsy. Read More

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http://dx.doi.org/10.1002/dta.2660DOI Listing
September 2019
5 Reads

Pathological consequences of low atmospheric pressure stunning in broiler chickens.

Animal 2020 Jan 26;14(1):129-137. Epub 2019 Jun 26.

Consultant Animal Welfare Science and Practice, Tulip House, 70 Borough High Street London Bridge, London SE1 1XF, UK.

Low atmospheric pressure stunning (LAPS) is a novel approach to pre-slaughter stunning of chickens using progressive hypobaric hypoxia by the application of gradual decompression (280s cycle) according to a set of prescribed pressure curves. Low atmospheric pressure stunning produces a non-recovery state. Concerns have been raised relating to the possible pathological and welfare consequences of expansion of air in the body during LAPS. Read More

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http://dx.doi.org/10.1017/S1751731119001411DOI Listing
January 2020
9 Reads

The alpha-2 receptor agonist dexmedetomidine attenuates vancomycin‑induced acute kidney injury.

Bratisl Lek Listy 2019 ;120(6):429-433

Objective: This study was conducted to evaluate the protective effect of dexmedetomidine on nephrotoxicity and the mechanism of renoprotection following vancomycin-induced nephrotoxicity in rats.

Methods: Thirty-two albino Wistar rats were divided into four groups. The control group received intraperitoneal (IP) physiological saline solution, the vancomycin (VMC) group received IP 200 mg/kg vancomycin, the dexmedetomidine (DEX) group received IP 5 µg/kg dexmedetomidine, and the vancomycin and dexmedetomidine (VMC+DEX) group received IP 200 mg/kg vancomycin followed by IP 5 µg/kg dexmedetomidine 20 min after the vancomycin injection. Read More

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http://dx.doi.org/10.4149/BLL_2019_069DOI Listing
August 2019
20 Reads

Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling.

Neurochem Int 2019 10 18;129:104493. Epub 2019 Jun 18.

Graduate Institute of Basic Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Glutamatergic excitotoxicity is crucial in the pathogenesis of epileptic seizures. Dexmedetomidine, a potent and highly selective α2 adrenoceptor agonist, inhibits glutamate release from nerve terminals in rat cerebrocortical nerve terminals. However, the ability of dexmedetomidine to affect glutamate-induced brain injury is still unknown. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.104493DOI Listing
October 2019
13 Reads

CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of .

Molecules 2019 Jun 8;24(11). Epub 2019 Jun 8.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Panyu District, Guangzhou 510006, Guangdong, China.

Celastrol and triptolide, as the two main bio-activity ingredients in have wide anticancer pharmacological potency, as well as anti-inflammatory and immunosuppression effects. However, they have potential hepatotoxicity and underlying mechanisms of them-induced toxicity mediated by hepatic CYP450s have not been well delineated. In the present study, we accessed the toxic effects and possible mechanism of celastrol and triptolide on primary rat hepatocytes. Read More

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http://dx.doi.org/10.3390/molecules24112162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600472PMC
June 2019
9 Reads

Zolpidem high-dose abuse: what about the liver? Results from a series of 107 patients.

Expert Opin Drug Saf 2019 Aug 14;18(8):753-758. Epub 2019 Jun 14.

c Department of Internal Medicine and Gastroenterology, Catholic University of Rome , Rome , Italy.

: Z-Drugs (ZDs) have been developed to limit benzodiazepines (BZDs) abuse for sleep disorders. Data on the liver toxicity of zolpidem (ZLM) are lacking or anecdotal. The authors evaluated the presence of drug-induced liver injury (DILI) among a cohort of high-dose ZLM abusers. Read More

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http://dx.doi.org/10.1080/14740338.2019.1628216DOI Listing
August 2019
19 Reads

Poloxamer-407 thickened lipid colloidal system of agomelatine for brain targeting: Characterization, brain pharmacokinetic study and behavioral study on Wistar rats.

Colloids Surf B Biointerfaces 2019 Sep 8;181:426-436. Epub 2019 May 8.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Electronic address:

The current study was designed to enhance the brain bioavailability and to extract maximum therapeutic benefit from a novel antidepressant drug, agomelatine. For this purpose, a thermoresponsive in situ gel was prepared by dissolving 20% w/v of Poloxamer-407 in agomelatine containing nanoemulsion. To impart mucoadhesive property, 0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.05.016DOI Listing
September 2019
11 Reads

Effect of trichloroacetaldehyde on the activation of CD4T cells in occupational medicamentosa-like dermatitis: An in vivo and in vitro study.

Toxicology 2019 07 29;423:95-104. Epub 2019 May 29.

Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China. Electronic address:

Occupational medicamentosa-like dermatitis induced by trichloroethylene (OMLDT) is a hypersensitivity disease with autoimmune liver injury, which has increasingly become a serious occupational health problem in China. However, the pathogenesis of OMLDT remained undefined. In this study, 30 TCE-induced OMLDT patients, 58 exposure controls, and 40 non-exposure controls were recruited. Read More

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http://dx.doi.org/10.1016/j.tox.2019.05.014DOI Listing
July 2019
1 Read

Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.

PLoS One 2019 29;14(5):e0217009. Epub 2019 May 29.

Laboratory of Vaccine & Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Researchers investigating cancer chemotherapy and management continue to search for agents that selectively kill malignant cells and leave healthy neighboring cells intact. Natural products provide relevant resources for anti-cancer drug discovery. However, the physicochemical properties of these compounds limit their efficient uptake and bioavailability. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217009PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541272PMC
January 2020
1 Read
3.234 Impact Factor

Measuring the middle-ear reflex: A quantitative method to assess effects of industrial solvents on central auditory pathways.

Neurotoxicology 2019 09 20;74:58-66. Epub 2019 May 20.

Institut National de Recherche et de Sécurité. F-54519, Vandœuvre-lès-Nancy, France.

Volatile organic solvents are frequently present in industrial atmospheres. Their lipophilic properties mean they quickly reach the brain following inhalation. Acute exposure to some solvents perturbs the middle ear reflex, which could jeopardize cochlear protection against loud noises. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X193004
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http://dx.doi.org/10.1016/j.neuro.2019.05.007DOI Listing
September 2019
15 Reads

Phenytoin toxicity due to drug interaction with doxepin and changes in patient factors.

Nurse Pract 2019 Jun;44(6):13-16

Samarth P. Shah is a clinical pharmacy specialist of internal medicine/acute stroke at Methodist University Hospital, Memphis, Tenn. Aseala Abousaud is a pharmacist at Emory Healthcare, Atlanta, Ga. Reshma R. Nair is a medical student at the American University of Integrative Sciences, School of Medicine, Tucker, Ga. Jaclyn Bergeron is a hospitalist at Methodist University Hospital, Memphis, Tenn., and an assistant professor of internal medicine at the University of Tennessee College of Medicine, Memphis, Tenn. B. Tate Cutshall is a clinical pharmacy specialist of internal medicine at Methodist University Hospital, Memphis, Tenn.

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http://dx.doi.org/10.1097/01.NPR.0000558162.07091.09DOI Listing
June 2019
5 Reads

Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins.

Neurotoxicology 2019 09 13;74:19-27. Epub 2019 May 13.

Israel Institute for Biological Research, Israel.

A common consequence of exposure to organophosphate nerve agents is the centrally mediated seizure activity that appears even after conventional treatment with atropine and oximes. We have previously demonstrated a major inflammatory response with subsequent brain damage which was correlated with the duration of the sarin-induced seizures (Chapman et al., 2006). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X193004
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http://dx.doi.org/10.1016/j.neuro.2019.05.006DOI Listing
September 2019
11 Reads

Propofol Alleviates Apoptosis Induced by Chronic High Glucose Exposure via Regulation of HIF-1 in H9c2 Cells.

Oxid Med Cell Longev 2019 10;2019:4824035. Epub 2019 Apr 10.

Department of Internal and Emergency Medicine, Shanghai General Hospital (Originally Named Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The sedative anesthetic, propofol, is a cardioprotective agent for hyperglycemia-induced myocardial hypertrophy and dysfunction in rats. However, the specific protective mechanism has not been clarified.

Methods And Results: In this experiment, we used H9c2 cells subjected to 22 mM glucose lasting for 72 hours as an in vitro model of cardiomyocyte injury by hyperglycemia and investigated the potential mechanism of propofol against hyperglycemic stress in cells. Read More

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http://dx.doi.org/10.1155/2019/4824035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481038PMC
December 2019
3 Reads

Determination of narcotic potency using a neurobehavioral assay with larval zebrafish.

Neurotoxicology 2019 09 11;74:67-73. Epub 2019 May 11.

Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory, and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA. Electronic address:

Background: Identifying chemicals with narcotic potency is an important aspect of assessing the safety of consumer products that may be accidentally ingested. A rapid and efficient assay of narcotic potency is desired for assessing chemicals with such suspected activity.

Objectives: This purpose of this research was to develop a non-mammalian vertebrate, high throughput, neurobehavioral method to assess the narcotic potency of chemicals using larval zebrafish. Read More

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http://dx.doi.org/10.1016/j.neuro.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750999PMC
September 2019
4 Reads
3.379 Impact Factor

Palmatine plays a role in sedation and hypnosis by increasing 5-hydroxytryptamine.

Cell Mol Biol (Noisy-le-grand) 2019 Apr 30;65(4):69-75. Epub 2019 Apr 30.

Department of Pain, Ganzhou People's Hospital, Ganzhou City, China.

Objective of this study was to investigate the sedative and hypnotic effects of palmatine and to observe whether its mechanism is related to 5-hydroxytryptamine (5-HT) and GABA. The sedative and hypnotic effects of palmatine on mice were observed with mouse autonomic activity test, direct sleep test, pentobarbital sodium in suprathreshold and subthreshold dose sleep test. The content of GABA and 5-HT in brain homogenate was determined by ELISA  method. Read More

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April 2019
10 Reads

Inhibitory Effect of Tricyclic Antidepressant Doxepin on Voltage-Dependent K Channels in Rabbit Coronary Arterial Smooth Muscle Cells.

Cardiovasc Toxicol 2019 10;19(5):465-473

Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea.

Doxepin, tricyclic antidepressant, is widely used for the treatment of depressive disorders. Our present study determined the inhibitory effect of doxepin on voltage-dependent K (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Vascular Kv currents were inhibited by doxepin in a concentration-dependent manner, with a half-maximal inhibitory concentration (IC) value of 6. Read More

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http://dx.doi.org/10.1007/s12012-019-09519-8DOI Listing
October 2019
2 Reads
2.060 Impact Factor

Involvement of miR-665 in protection effect of dexmedetomidine against Oxidative Stress Injury in myocardial cells via CB2 and CK1.

Biomed Pharmacother 2019 Jul 23;115:108894. Epub 2019 Apr 23.

Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China. Electronic address:

Background: Dexmedetomidine (Dex) can confer cardioprotective effects against ischemia/reperfusion (I/R) injury. While there are no studies addressing cardioprotection of Dex via regulation of microRNAs. The purpose of this study was to examine the roles and mechanisms of microRNA in cardioprotection of dexmedetomidine. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108894DOI Listing
July 2019
2.023 Impact Factor

Cooling to Facilitate Metabolic Suppression in Healthy Individuals.

Aerosp Med Hum Perform 2019 May;90(5):475-479

Carbon dioxide (CO₂) toxicity could be catastrophic for astronauts. Suppressing metabolism by lowering body temperature decreases CO₂ production and may facilitate rescue in the event of a crippled ship. Lowering body temperature requires shivering suppression. Read More

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http://dx.doi.org/10.3357/AMHP.5284.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077737PMC
May 2019
3 Reads

Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine.

Bratisl Lek Listy 2019 ;120(4):270-276

Objective And Background: Acute acetaminophen (APAP) overdose has been shown to cause toxicity and the primary treatment medication is N-acetylcysteine (NAC). Dexmedetomidine (DEX) is a sedative drug with known antioxidant properties. We researched whether DEX has an injury-reducing effect on toxicity. Read More

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http://dx.doi.org/10.4149/BLL_2019_047DOI Listing
June 2019
10 Reads

Propofol alleviates cisplatin-related cognitive impairment.

Authors:
Yu Zhou Yimin Qiu

Neurol Sci 2019 Aug 23;40(8):1645-1649. Epub 2019 Apr 23.

Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Chemotherapy-related cognitive impairment (CRCI) is commonly reported following the administration of chemotherapeutic agents and comprises a wide variety of neurological problems. Many patients after chemotherapy need further surgery under anesthesia. Thus, in this study, we examined whether propofol, one of the most commonly used anesthetics in surgery, could further affect the cognitive abilities in mouse CRCI models. Read More

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http://dx.doi.org/10.1007/s10072-019-03895-3DOI Listing
August 2019
1 Read

Dexmedetomidine reduced sevoflurane-induced neurodegeneration and long-term memory deficits in neonatal rats.

Authors:
Toru Goyagi

Int J Dev Neurosci 2019 Jun 5;75:19-26. Epub 2019 Apr 5.

Department of Anesthesia and Intensive Care Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita 010-8543, Japan. Electronic address:

Exposure to sevoflurane and other inhalational anesthetics can induce neurodegeneration in the developing brain. Although dexmedetomidine (DEX) has provided neuroprotection against hypoxic ischemic injury, relatively little is known about whether it has the neuroprotective effects against anesthetic-induced neurodegeneration. This study examined whether DEX improves the long-term cognitive dysfunction observed after exposure of neonatal rats to 3% sevoflurane. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748193001
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http://dx.doi.org/10.1016/j.ijdevneu.2019.04.002DOI Listing
June 2019
2 Reads

Protective effects of propofol on experimental neonatal acute lung injury.

Mol Med Rep 2019 May 1;19(5):4507-4513. Epub 2019 Apr 1.

Department of Pediatric Surgery, Maternal and Child Health Care Hospital of Qujing, Qujing, Yunnan 655000, P.R. China.

The present study aimed to investigate the effects of propofol on neonatal acute lung injury (ALI) in a rat model and to examine the molecular mechanisms underlying propofol function. A rat model of ALI was established by intraperitoneal injection of lipopolysaccharides (LPS). The neonatal rats were treated with various concentrations of propofol and a lung injury score was assessed. Read More

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http://dx.doi.org/10.3892/mmr.2019.10113DOI Listing
May 2019
25 Reads

Oxymatrine ameliorates agomelatine-induced hepatocyte injury through promoting proteasome-mediated CHOP degradation.

Biomed Pharmacother 2019 Jun 27;114:108784. Epub 2019 Mar 27.

Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Background: The novel antidepressant drug agomelatine has been observed to cause adverse effect of hepatotoxicity in clinical applications. This study was designed to explore protective agents and investigated the underlying mechanism on L02 cells.

Method: L02 cells were treated with agomelatine and oxymatrine (OMT) and cell apoptosis were analyzed through flow cytometric analysis, CCK-8 assay and TUNEL assay. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322193046
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http://dx.doi.org/10.1016/j.biopha.2019.108784DOI Listing
June 2019
25 Reads