3,900 results match your criteria Toxicity Salicylate


Exogenous salicylic acid alleviates fomesafen toxicity by improving photosynthetic characteristics and antioxidant defense system in sugar beet.

Ecotoxicol Environ Saf 2022 Jun 2;238:113587. Epub 2022 May 2.

Research Institute of Economic Crops, Xinjiang Academy of Agricultural Sciences, Urumqi, Xinjiang 830091, China. Electronic address:

Fomesafen herbicide application has become major pollution in the growth and production of crops. Spraying fomesafen on the target crops may drift out to non-target crops. In northeast China, sugar beets are always planted adjacent to soybeans. Read More

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Antiangiogenic Activity of Sweet Almond (Prunus dulcis) Oil Alone and in Combination with Aspirin in both in vivo and in vitro Assays.

Asian Pac J Cancer Prev 2022 04 1;23(4):1405-1413. Epub 2022 Apr 1.

Department Pharmacology and Toxicology, College of Pharmacy, AL-Nahrain University, Iraq.

Objective: Angiogenesis is new blood vessels formations that are necessary for certain physiological and pathologic conditions. Almond oil represents adjuvant therapies for numerous health benefits; It has ability for prevent the formation angiogenesis in tumour, due to its high concentration of unsaturated fatty acids, polyphenols, flavonoids and other ingredients content. Aspirin is non-steroidal ant-inflammatory drug; significantly reduce the angiogenesis of cancer. Read More

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Aspirin inhibits stem cell proliferation during freshwater Dugesia japonica regeneration by STAT3/SOX2/OCT4 signaling pathway.

Aquat Toxicol 2022 Jun 10;247:106158. Epub 2022 Apr 10.

College of Life Science, Henan Normal University, Xinxiang, 453007 Henan, China.

As a widely used drug in clinical practice, aspirin has a large number of residual drugs and metabolites discharged into the environment during the pharmaceutical process or after taking the drug. Aspirin content and its metabolite, salicylic acid, have been reported and detected in several river water samples and municipal wastewaters. However, little is known about the toxicity mechanisms of this drug in aquatic invertebrates. Read More

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[Specific pharmacological treatment guide for transthyretin amyloid cardiomyopathy, 2021].

Medicina (B Aires) 2022 ;82(2):275-288

Servicio de Cardiología, Hospital Italiano de Buenos Aires, Argentina.

This clinical practice guideline for treating transthyretin amyloid (ATTR) cardiomyopathy is based on the best available evidence of clinical effectiveness. The PICO format was used to generate a list of questions focused on the effectiveness and safety of the specific treatment of patients with ATTR cardiomyopathy. The search was conducted in PubMed, Cochrane and Epistemokus, between July-August 2020, and selected articles between 2000-2020, in English and Spanish. Read More

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Prediction of Low-Dose Aspirin-Induced Gastric Toxicity Using Nuclear Magnetic Resonance Spectroscopy-Based Pharmacometabolomics in Rats.

Molecules 2022 Mar 25;27(7). Epub 2022 Mar 25.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.

Background: Low-dose aspirin (LDA) is the backbone for secondary prevention of coronary artery disease, although limited by gastric toxicity. This study aimed to identify novel metabolites that could predict LDA-induced gastric toxicity using pharmacometabolomics.

Methods: Pre-dosed urine samples were collected from male Sprague-Dawley rats. Read More

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The new HFA/ICOS risk assessment tool to identify patients with chronic myeloid leukaemia at high risk of cardiotoxicity.

ESC Heart Fail 2022 Jun 31;9(3):1914-1919. Epub 2022 Mar 31.

Cardiology Unit, University Hospital Paolo Giaccone, Palermo, Italy.

Aims: Tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukaemia (CML) can cause cardiovascular adverse events. So far, the Systematic Coronary Risk Evaluation (SCORE) charts of the European Society of Cardiology (ESC) have been used to identify cancer patients at increased cardiovascular risk. The primary aim of our study was to evaluate the usefulness of the new cardiovascular risk assessment model proposed by the Cardio-Oncology Study Group of the Heart Failure Association (HFA) of the ESC in collaboration with the International Cardio-Oncology Society (ICOS) to stratify the cardiovascular risk in CML patients, compared with SCORE risk charts. Read More

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Histological endpoints and oxidative stress transcriptional responses in the Mediterranean mussel Mytilus galloprovincialis exposed to realistic doses of salicylic acid.

Environ Toxicol Pharmacol 2022 May 25;92:103855. Epub 2022 Mar 25.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98166, Italy.

Despite the availability of analytic data, little is known about the toxicity of salicylic acid (SA) on aquatic non-target organisms. The present study aimed at evaluating the impact of SA through a short-term exposure of the Mediterranean mussel Mytilus galloprovincialis to five environmentally relevant concentrations of SA. A set of suitable biomarkers was applied at selected time-points on mussel digestive glands, including histological observations and expression of oxidative stress related genes. Read More

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Spirulina supplements: an approach moderating aspirin persuaded histological and ultra-structural alterations in albino rats gastric mucosa.

Ultrastruct Pathol 2022 Mar;46(2):204-216

Anatomy Department, Faculty of Medicine, Ain Shams University, Cairo, ‎Egypt.

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most used drugs. The pathogenesis of aspirin-induced gastric ulceration includes blocking the activities of the cyclooxygenase enzymes (COX-1 and COX-2) leading to reduced mucus and bicarbonate secretion. contains many functional bioactive ingredients with antioxidant and anti-inflammatory activities, including phenolic phytochemicals and phycobiliprotein C-phycocyanin. Read More

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Exogenous SA Affects Rice Seed Germination under Salt Stress by Regulating Na/K Balance and Endogenous GAs and ABA Homeostasis.

Int J Mol Sci 2022 Mar 18;23(6). Epub 2022 Mar 18.

College of Plant Protection, Shandong Agricultural University, Tai'an 271000, China.

Salinity reduces agricultural productivity majorly by inhibiting seed germination. Exogenous salicylic acid (SA) can prevent the harm caused to rice by salinity, but the mechanisms by which it promotes rice seed germination under salt stress are unclear. In this study, the inhibition of germination in salt-sensitive Nipponbare under salt stress was greater than that in salt-tolerant Huaidao 5. Read More

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Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4.

Auris Nasus Larynx 2022 Mar 16. Epub 2022 Mar 16.

Department of Intelligent Information System, Tohoku Bunka Gakuen University, Sendai, Japan.

Objective: Pendrin is a transmembrane protein encoded by the SLC26A4 gene that functions in maintaining ion concentrations in the endolymph of the inner ear, most likely by acting as a chloride/bicarbonate transporter. Variants in the SLC26A4 gene are responsible for sensorineural hearing loss. Although pendrin localizes to the plasma membrane, we previously identified that 8 missense allele products of SLC26A4 were retained in the intracellular region and lost their anion exchange function. Read More

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Thiocyanate toxicity: a teaching case.

Clin Toxicol (Phila) 2022 Mar 4:1-6. Epub 2022 Mar 4.

Harvard Medical Toxicology Program, Boston Children's Hospital, Boston, MA, USA.

Thiocyanate can cause gastrointestinal, neurologic, and cardiovascular toxicity. Additionally, it interferes with multiple laboratory assays. We present a case of acute thiocyanate toxicity. Read More

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Proximal Tubule Dysfunction Secondary to Salicylate Intoxication.

Glob Pediatr Health 2022 22;9:2333794X211050800. Epub 2022 Feb 22.

Kootenai Medical Center, Coeur d'Alene, ID, USA.

Aspirin overdose is still a common cause of presentation to the emergency department and is commonly seen in the setting of one-time, accidental or intentional ingestion of large amounts of salicylate-containing compounds, though can occur with long-term ingestion of super-therapeutic doses of medications. Salicylate toxicity has a predictable progression from early respiratory alkalosis to late metabolic acidosis. We present the case of a 14-year-old girl who intentionally ingested a handful of Aspirin and despite appropriate therapy, developed transient proximal tubule dysfunction. Read More

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February 2022

Reflections on Aspirin Toxicity: Interpreting Effects of Sodium Bicarbonate and Activated Charcoal.

J Med Toxicol 2022 Apr 14;18(2):172-173. Epub 2022 Feb 14.

Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.

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Development and Validation of a Novel HPLC Method to Analyse Metabolic Reaction Products Catalysed by the CYP3A2 Isoform: In Vitro Inhibition of CYP3A2 Enzyme Activity by Aspirin (Drugs Often Used Together in COVID-19 Treatment).

Molecules 2022 Jan 29;27(3). Epub 2022 Jan 29.

School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston-upon-Thames, London KT1 2EE, UK.

Aspirin (also known as acetylsalicylic acid) is a drug intended to treat fever, pain, or inflammation. Treatment of moderate to severe cases of COVID-19 using aspirin along with dexamethasone has gained major attention globally in recent times. Thus, the purpose of this study was to use High-Performance Liquid Chromatography (HPLC) to evaluate the in vitro inhibition of CYP3A2 enzyme activity using aspirin in rat liver microsomes (RLMs). Read More

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January 2022

Epigenetic mechanisms of DNA methylation in the transgenerational effect of ethylhexyl salicylate on zebrafish.

Chemosphere 2022 May 9;295:133926. Epub 2022 Feb 9.

Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, PR China.

In this study, a 120-day whole-life cycle exposure and oviposition experiment on zebrafish with maternal and paternal mixed mating strategy was conducted to investigate the epigenetic mechanism of DNA methylation in ethylhexyl salicylate (EHS, 1, 10, 100 μg/L)-induced transgenerational effects. Results showed that EHS could induce the decrease of DNA methyltransferase 1 (DNMT1) activity and average global DNA methylation level in maternal parents and the increase of the above indexes in paternal parents, while the change of glycine N-methyltransferase activity was opposite to DNMT1. The average global DNA methylation levels were significantly increased in the offsprings of both parents exposed and father-only exposed to EHS, suggesting that EHS-induced epigenetic modifications may be stable and heritable. Read More

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Molecular mechanism of the TGF‑β/Smad7 signaling pathway in ulcerative colitis.

Mol Med Rep 2022 04 9;25(4). Epub 2022 Feb 9.

Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

Aberrant TGF‑β/Smad7 signaling has been reported to be an important mechanism underlying the pathogenesis of ulcerative colitis. Therefore, the present study aimed to investigate the effects of a number of potential anti‑colitis agents on intestinal epithelial permeability and the TGF‑β/Smad7 signaling pathway in an experimental model of colitis. A mouse model of colitis was first established before anti‑TNF‑α and 5‑aminosalicyclic acid (5‑ASA) were administered intraperitoneally and orally, respectively. Read More

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The inhibiting effect of Aspirin Triggered-Resolvin D1 in non-canonical pyroptosis in rats with acute keratitis.

Exp Eye Res 2022 05 1;218:108938. Epub 2022 Feb 1.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai, China. Electronic address:

Purpose: To investigate the effect of Aspirin Triggered-Resolvin D1 (AT-RvD1) as an anti-pyroptosis and anti-inflammatory agent on lipopolysaccharide (LPS) induced acute keratitis in Wistar rats.

Methods: Acute keratitis in rats were induced by LPS stromal injection. Inflammatory reaction was measured by clinical score and histological observations. Read More

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Acute Renal Impairment in Patients Due to Paracetamol Overdose in the Absence of Hepatic Impairment.

Cureus 2021 Dec 27;13(12):e20727. Epub 2021 Dec 27.

Internal Medicine and Diabetes and Endocrinology, Barking, Havering and Redbridge University Hospitals NHS Trust, London, GBR.

In general, paracetamol poisoning is associated with hepatotoxicity and very rarely with renal impairment in the absence of significant hepatic impairment. Paracetamol poisoning associated with renal impairment is rare, and it is mostly associated with hepatotoxicity. Most patients with acute renal impairment show a pattern of acute tubular necrosis or injury based on their blood, clinical presentation, and imaging. Read More

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December 2021

"Hepatotoxicity in inflammatory bowel disease: mesalazine, the forgotten drug".

Eur J Gastroenterol Hepatol 2021 12;33(1S Suppl 1):e1067-e1070

Gastroenterology and Hepatology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

Introduction: Mesalazine is a widely prescribed drug, used for the treatment of ulcerative colitis to both induce and maintain remissions in disease. Mesalazine therapy has been associated with a low rate of serum enzyme elevations and a with rare instances of clinically apparent acute liver injury.

Case Presentation: A 51-year-old Caucasian woman with ulcerative colitis was treated with mesalazine. Read More

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December 2021

Polypyrrole-Coated Mesoporous TiO Nanocomposites Simultaneously Loading DOX and Aspirin Prodrugs for a Synergistic Theranostic and Anti-Inflammatory Effect.

ACS Appl Bio Mater 2021 02 3;4(2):1483-1492. Epub 2021 Feb 3.

State Key Laboratory of Fire Science, University of Science and Technology of China, Swan Lake Road 1, Hefei 230026, Anhui, P. R. China.

Although a number of therapeutic strategies have been applied in cancer therapy, treatment for cancer metastasis is challenging due to unsatisfactory cure rate and easy cancer recurrence. In our work, nanocomposites (NCs) based on polypyrrole-coated mesoporous TiO with a suitable size are prepared through a modified soft-templating strategy, which integrates double prodrugs (doxorubicin (DOX) prodrug and aspirin prodrug) with superior drug loading capacity. Under external stimulation of near-infrared (NIR) and ultrasound (US), the prepared nanocomposites have an excellent photothermal conversion efficiency (over 50. Read More

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February 2021

Aspirin ameliorates the cognition impairment in mice following benzo[a]pyrene treatment via down-regulating BDNF IV methylation.

Neurotoxicology 2022 03 31;89:20-30. Epub 2021 Dec 31.

Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China; Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, Taiyuan, 030001, Shanxi, China; Key Laboratory of Cellular Physiology, Shanxi Province, Taiyuan, 030001, Shanxi, China; Department of Physiology, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. Electronic address:

Benzo[a]pyrene (B[a]P) is neurotoxic, however, the mechanisms remain unclear and there is no effective prevention. Available evidence suggests a role of DNA methylation in B[a]P-induced neurotoxicity. This study investigated the brain-derived neurotrophic factor (BDNF) IV methylation in the development of and aspirin intervention against B[a]P's neurotoxicity in mice and HT22 cells. Read More

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Improvement of salicylic acid biological effect through its encapsulation with silica or chitosan.

Int J Biol Macromol 2022 Feb 30;199:108-120. Epub 2021 Dec 30.

Departamento de Ingeniería Química, Instituto Universitario de Tecnología Cerámica, Universitat Jaume I, 12071 Castellón, Spain. Electronic address:

Attacks of necrotrophic and biotrophic fungi affect a large number of crops worldwide and are difficult to control with fungicides due to their genetic plasticity. Encapsulation technology is a good alternative for controlling fungal diseases. In this work, encapsulated samples of salicylic acid (SA) with silica (Si:SA) or chitosan (Ch:SA) at three different ratios were prepared by spray drying, and morphological and physicochemical characterised. Read More

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February 2022

The combined supplementation of melatonin and salicylic acid effectively detoxifies arsenic toxicity by modulating phytochelatins and nitrogen metabolism in pepper plants.

Environ Pollut 2022 Mar 29;297:118727. Epub 2021 Dec 29.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address:

The main objective of the study was to assess if joint application of melatonin (MT, 0.1 mM) and salicylic acid (SA 0.5 mM) could improve tolerance of pepper plants to arsenic (As) as sodium hydrogen arsenate heptahydrate (0. Read More

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Salicylate and glutamate mediate different Cd accumulation and tolerance between Brassica napus and B. juncea.

Chemosphere 2022 Apr 29;292:133466. Epub 2021 Dec 29.

College of Resources, Sichuan Agricultural University, Chengdu, 611130, China. Electronic address:

Most hyperaccumulator plants have little economic values, and therefore have not been widely used in Cd-contaminated soils. Rape species are Cd hyperaccumulators with high economic values. Black mustard seed (Brassica juncea) has a higher accumulation ability and a higher tolerance for Cd than oilseed rape (Brassica napus), but its biomass is relatively low and its geographical distribution is limited. Read More

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Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?

Toxins (Basel) 2021 12 14;13(12). Epub 2021 Dec 14.

IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, 31024 Toulouse, France.

Colibactin is a genotoxin produced primarily by harboring the genomic island ( ).   cause host cell DNA damage, leading to chromosomal instability and gene mutations. The signature of colibactin-induced mutations has been described and found in human colorectal cancer (CRC) genomes. Read More

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December 2021

5‑Aminosalicylic acid attenuates paraquat‑induced lung fibroblast activation and pulmonary fibrosis of rats.

Mol Med Rep 2022 02 16;25(2). Epub 2021 Dec 16.

Department of Pathology, The Second Hospital, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.

Pulmonary fibrosis is one of the most important pathological processes associated with paraquat (PQ) poisoning. 5‑Aminosalicylic acid (5‑ASA) has been shown to be a promising agent against fibrotic diseases. In the present study, the alleviating role of 5‑ASA was evaluated in a rat model of pulmonary fibrosis induced by PQ intragastric poisoning (80 mg/kg). Read More

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February 2022

Suppression of MYC transcription activators by the immune cofactor NPR1 fine-tunes plant immune responses.

Cell Rep 2021 12;37(11):110125

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Aichi 464-8602, Japan; Center for Gene Research, Nagoya University, Chikusa, Nagoya, Aichi 464-8602, Japan. Electronic address:

Plants tailor immune responses to defend against pathogens with different lifestyles. In this process, antagonism between the immune hormones salicylic acid (SA) and jasmonic acid (JA) optimizes transcriptional signatures specifically to the attacker encountered. Antagonism is controlled by the transcription cofactor NPR1. Read More

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December 2021

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells.

Front Pharmacol 2021 18;12:779801. Epub 2021 Nov 18.

Molecular Preventive Medicine, University Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.

Herbal preparations of willow bark ( cortex) are available in many countries as non-prescription medicines for pain and inflammation, and also as dietary supplements. Currently only little information on toxicity and drug interaction potential of the extracts is available. This study now evaluated the effects of two cortex extracts on human hepatocyte-like HepaRG cells, in view of clinically relevant CYP450 enzyme activity modulation, cytotoxicity and production of reactive oxygen species (ROS). Read More

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November 2021

Activated Charcoal and Bicarbonate for Aspirin Toxicity: a Retrospective Series.

J Med Toxicol 2022 01 29;18(1):30-37. Epub 2021 Nov 29.

Clinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia.

Introduction: Aspirin overdose causes acid-base disturbances and organ dysfunction. Management is guided by research reported over 50 years ago when chronic aspirin toxicity was common and accounted for significant morbidity. We investigate our experience of aspirin overdose and the effectiveness of charcoal and bicarbonate administration over 20 years. Read More

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January 2022