938 results match your criteria Toxicity Rodenticide


Sudden Cardiac Arrest in an Asymptomatic Zinc Phosphide-Poisoned Patient: A Case Report.

Cardiovasc Toxicol 2020 May 25. Epub 2020 May 25.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zinc phosphide is a gray to black powder mainly used as a rodenticide. In contact with gastric fluid, it releases phosphine which is the main toxic material of this compound. Phosphine interferes with oxidative respiratory cycle of the cells, but is generally expected to manifest its toxicity with prodromal signs and symptoms including abdominal pain, nausea and vomiting, metabolic acidosis, and increased liver function tests. Read More

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http://dx.doi.org/10.1007/s12012-020-09578-2DOI Listing

Rare Interaction of Warfarin and Digoxin in a Case of Digoxin Toxicity.

J Assoc Physicians India 2020 Mar;68(3):85-86

Vikas Banyal.

Warfarin is known to interact with many drugs and can lead to serious consequences. We report a case of 52 years old female patient from Himachal Pradesh. During hospital stay patient developed coagulopathy in form of INR above 10 and bradycardia with ventricular rate on ECG with digoxin level of 3. Read More

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Vitamin K antagonist rodenticides display different teratogenic activity.

Reprod Toxicol 2020 Apr 8;93:131-136. Epub 2020 Feb 8.

USC 1233 RS2GP, VetAgro Sup, INRA, Univ Lyon, F-69280, Marcy L'Etoile, France. Electronic address:

Vitamin K antagonists (VKA) are not recommended during pregnancy because warfarin (a first-generation VKA) is associated with a malformation syndrome "the fetal warfarin syndrome" (FWS). VKA are also used for rodent management worldwide. Recently, the Committee for Risk Assessment responsible for the European chemical legislation for advances on the safe use of chemicals had classed 8 anticoagulant used as rodenticides in the reprotoxic category 1A or 1B. Read More

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http://dx.doi.org/10.1016/j.reprotox.2020.02.003DOI Listing

Acute toxicity and clotting times of anticoagulant rodenticides to red-toothed (Odonus niger) and black (Melichthys niger) triggerfish, fathead minnow (Pimephales promelas), and largemouth bass (Micropterus salmoides).

Aquat Toxicol 2020 Apr 1;221:105429. Epub 2020 Feb 1.

Columbia Environmental Research Center, U.S. Geological Survey, Department of Interior 4200 New Haven Road Columbia, MO 65201, USA. Electronic address:

Anticoagulant rodenticides (ARs) are used in rat eradication efforts on island wildlife refuges. AR bait pellets can get into coral reef areas during broadcasting and lead to exposure of non-target organisms, such as marine fishes. The objective of this study was to determine the sensitivity of representative saltwater fishes, Red-toothed triggerfish (Odonus niger) and Black triggerfish (Melichthys niger), and common freshwater fishes, fathead minnow (Pimephales promelas), and largemouth bass (Micropterus salmoides) to first generation ARs, diphacinone (DPN) and chlorophacinone (CPN), as well as a second-generation AR, brodifacoum (BROD). Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105429DOI Listing

Plasma fluoroacetic acid concentrations: Symptoms, hematological, and biochemical characteristics in patients with fluoroacetic acid poisoning in the emergency department.

Hum Exp Toxicol 2020 May 20;39(5):634-641. Epub 2020 Jan 20.

Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Fluoroacetic acid (FAcOH) was once a highly toxic rodenticide widely used in the world. In the past, studies on the toxicity of FAcOH have focused on animal experiments. The toxicity of FAcOH to humans and the changes of FAcOH in plasma have not been studied. Read More

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http://dx.doi.org/10.1177/0960327119897743DOI Listing

Types of pesticides involved in domestic and wild animal poisoning in Italy.

Sci Total Environ 2020 Mar 15;707:136129. Epub 2019 Dec 15.

Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy.

Data obtained from samples of poisoned domestic and wild animals sent for toxicological evaluation during the period between 2005 and 2014 have been analyzed. Among the 4606 tested samples, the majority of which were collected in the northern regions of Italy, 2006 (43.55%) were found positive for pesticides. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.136129DOI Listing

Corticosterone mediates telomere length in raptor chicks exposed to chemical mixture.

Sci Total Environ 2020 Mar 21;706:135083. Epub 2019 Nov 21.

Laboratoire Chrono-environment - University Bourgogne Franche-Comté, UMR/CNRS 6249, 16 route de Gray, 25030 Besançon, France.

Stressors experience early in life by animals may have carry over impacts on life-traits over the life cycle. Accelerated telomere attrition induced by stress during development and growth could play a role in such delayed effects. Among stressors, exposure to chemicals may modify telomere dynamic but, to date, the trends evidenced between exposure and telomere shortening remains inconsistent. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.135083DOI Listing

3D spheroids generated on carbon nanotube-functionalized fibrous scaffolds for drug metabolism and toxicity screening.

Biomater Sci 2019 Dec;8(1):426-437

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China.

The mechanical and electrical stimuli have a profound effect on the cellular behavior and function. In this study, a series of conductive nanofibrous scaffolds are developed by blend electrospinning of poly(styrene-co-maleic acid) (PSMA) and multiwalled-carbon nanotubes (CNTs), followed by grafting galactose as cell adhesion cues. When the mass ratios of CNTs to PSMA increase up to 5%, the alignment, Young's modulus and conductivity of fibrous scaffolds increase, whereas the average diameter, pore size and elongation at break decrease. Read More

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http://dx.doi.org/10.1039/c9bm01310eDOI Listing
December 2019

Pathological changes induced by phosphine poisoning: a study on 8 children.

Int J Legal Med 2020 Jan 11;134(1):217-228. Epub 2019 Nov 11.

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Hankou, Wuhan, 430030, People's Republic of China.

Aluminum phosphide (ALP) has been extensively used as an economical and effective insecticide, rodenticide, and fumigant. The active ingredient of ALP is phosphine (PH), the use of which can lead to accidental inhalation and mass poisoning with high mortality. Exposure to PH will give rise to global damage in the human body. Read More

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http://dx.doi.org/10.1007/s00414-019-02169-zDOI Listing
January 2020
2.714 Impact Factor

Brodifacoum Toxicity in American Kestrels (Falco sparverius) with Evidence of Increased Hazard on Subsequent Anticoagulant Rodenticide Exposure.

Environ Toxicol Chem 2020 Feb;39(2):468-481

National Wildlife Research Center, Animal and Plant Health Inspection Service, US Department of Agriculture, Fort Collins, Colorado, USA.

A seminal question in ecotoxicology is the extent to which contaminant exposure evokes prolonged effects on physiological function and fitness. A series of studies were undertaken with American kestrels ingesting environmentally realistic concentrations of the second-generation anticoagulant rodenticide (SGAR) brodifacoum. Kestrels fed brodifacoum at 0. Read More

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http://dx.doi.org/10.1002/etc.4629DOI Listing
February 2020

Bromadiolone poisoning leading to subarachnoid haemorrhage: A case report and review of the literature.

J Clin Pharm Ther 2019 Dec 26;44(6):958-962. Epub 2019 Sep 26.

Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

What Is Known And Objective: Many cases of rodenticide poisoning have been reported. Bromadiolone, often called a super-warfarin, is a second-generation dicoumarin rodenticide with long half-life. The main clinical manifestations of bromadiolone poisoning are excessive or inappropriate bleeding of skin mucosa, digestive tract and urinary tract. Read More

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http://dx.doi.org/10.1111/jcpt.13005DOI Listing
December 2019
2 Reads

Dying to be Ill: Munchausen meets warfarin overdose.

J Family Med Prim Care 2019 Aug 28;8(8):2741-2743. Epub 2019 Aug 28.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.

Patients with severe coagulopathy related to vitamin K deficient proteins can be associated with surreptitious ingestion of vitamin K antagonists. Our patient presented acutely with extensive ecchymosis, gingival bleeding and hematuria. Her initial PT and PTT were prolonged and INR was >12. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_453_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753795PMC
August 2019
3 Reads

Synthetic cannabinoid-associated coagulopathy secondary to long-acting anticoagulant rodenticides: Observational case series and management recommendations.

Medicine (Baltimore) 2019 Sep;98(36):e17015

Department of Hematology, Johns Hopkins Hospital.

Synthetic cannabinoids have become increasingly popular drugs of abuse due to low cost and inability to detect these substances on routine drug screenings. In the United States, incidence of synthetic cannabinoid contamination with long-acting anticoagulant rodenticides (LAARs) resulting in coagulopathy and bleeding complications has been described.We sought to describe the natural history, management approach, and outcomes of bleeding secondary to synthetic cannabinoid-associated LAAR toxicity in an observational case series of patients evaluated at an urban academic medical system. Read More

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http://Insights.ovid.com/crossref?an=00005792-201909060-0002
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http://dx.doi.org/10.1097/MD.0000000000017015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739027PMC
September 2019
12 Reads
5.723 Impact Factor

Release of Munitions Constituents in Aquatic Environments Under Realistic Scenarios and Validation of Polar Organic Chemical Integrative Samplers for Monitoring.

Environ Toxicol Chem 2019 11 3;38(11):2383-2391. Epub 2019 Oct 3.

US Navy Space and Naval Warfare Systems Center Pacific, San Diego, California.

Munitions constituents (MC) may be released into aquatic environments as a result of underwater military munitions (UWMM) corrosion and breach. The present study investigated the release of 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) from Composition B fragments under 2 realistic exposure scenarios in a large flume with flow set at 15 cm/s: the first represented the release of MC from fully exposed Composition B, and the second represented release through a small hole, simulating a breached munition. Release of MC through a small hole was approximately 10 times lower than from exposed Composition B, demonstrating the strong influence of exposure to flow on release. Read More

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http://dx.doi.org/10.1002/etc.4553DOI Listing
November 2019
2 Reads

Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner - From molecular mechanisms to environmental concerns.

Ecotoxicol Environ Saf 2019 Oct 22;181:559-571. Epub 2019 Jun 22.

Centro de Ciências do Mar (CCMAR), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal; Center for Aquaculture Research, Agrarian Technological Institute of Castile and Leon, Ctra. Arévalo, S/n. 40196 Zamarramala, Segovia, Spain. Electronic address:

Warfarin is the most worldwide used anticoagulant drug and rodenticide. Since it crosses placental barrier it can induce warfarin embryopathy (WE), a fetal mortality in neonates characterized by skeletal deformities in addition to brain hemorrhages. Although the effects of warfarin exposure in aquatic off target species were already described, the particular molecular toxicological mechanisms during early development are still unclear. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.06.042DOI Listing
October 2019
5 Reads

Chrysin ameliorates ANTU-induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs.

J Biochem Mol Toxicol 2019 Jul 11;33(7):e22332. Epub 2019 Apr 11.

Department of Neurology, the Second Clinical Hospital of Jilin University, Changchun, Jilin, China.

Alpha-naphthylthiourea (ANTU), a rodenticide induces lung toxicity. Chrysin a flavonoid possesses antioxidant, anti-inflammatory, and antihypertensive potential. The aim of this study was to evaluate the efficacy of chrysin against ANTU-induced pulmonary edema (PE) and pulmonary arterial hypertension (PAH) in laboratory rats. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22332
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http://dx.doi.org/10.1002/jbt.22332DOI Listing
July 2019
18 Reads
1.925 Impact Factor

Live applications of norbormide-based fluorescent probes in Drosophila melanogaster.

PLoS One 2019 8;14(4):e0211169. Epub 2019 Apr 8.

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

In this study we investigated the performance of two norbormide (NRB)-derived fluorescent probes, NRBMC009 (green) and NRBZLW0047 (red), on dissected, living larvae of Drosophila, to verify their potential application in live cell imaging confocal microscopy. To this end, larval tissues were exposed to NRB probes alone or in combination with other commercial dyes or GFP-tagged protein markers. Both probes were rapidly internalized by most tissues (except the central nervous system) allowing each organ in the microscope field to be readily distinguished at low magnification. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211169PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453474PMC
December 2019
3 Reads

Medical outcomes of bromethalin rodenticide exposures reported to US poison centers after federal restriction of anticoagulants.

Clin Toxicol (Phila) 2019 Nov 20;57(11):1109-1114. Epub 2019 Mar 20.

Wisconsin Poison Center , Milwaukee , WI , USA.

Exposures to bromethalin rodenticides have increased since restrictions were placed on long acting anticoagulant rodenticide (LAAR) registrations in 2008. Bromethalin works, in part, by uncoupling mitochondrial oxidative phosphorylation. Toxicity in humans is not well characterized and no antidote is available. Read More

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http://dx.doi.org/10.1080/15563650.2019.1582776DOI Listing
November 2019
8 Reads

Correlation of MRI with the Neuropathologic Changes in Two Cats with Bromethalin Intoxication.

J Am Anim Hosp Assoc 2019 May/Jun;55(3):e55302. Epub 2019 Mar 14.

From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia (M.K., R.M.B., S.R.P.); Section of Neurology/Neurosurgery, Red Bank Veterinary Hospital, Tinton Falls, New Jersey (E.N.G., R.B.S.); Friendship Hospital for Animals, Washington, District of Columbia (L.B., E.J.H.); and Section of Anatomic Pathology, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York (A.dL., A.D.M.).

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http://dx.doi.org/10.5326/JAAHA-MS-6724DOI Listing
September 2019
6 Reads

A note on wildlife poisoning cases from Kerala, South India.

2018 Sep;64(58)

Department of Infectious Disease Epidemiology, Imperial College London, St. Mary's campus, Norfolk place, London W2 1PG, United Kingdom.

Wildlife poisoning is an important conservation threat for endangered species in India. There are no publications in the scientific literature that identify the specific poisons or chemicals involved in wildlife poisoning cases from the state of Kerala. In this report, all cases of wildlife mortality recorded between 2011 and 2013 at the office of the Assistant Forest Veterinary Officer, Periyar Tiger Reserve in Kerala were reviewed and cases where poisoning was considered as a differential diagnosis were identified. Read More

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http://dx.doi.org/10.1007/s10344-018-1218-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390940PMC
September 2018
14 Reads

The relative toxicity of brodifacoum enantiomers.

Toxicol Lett 2019 May 16;306:61-65. Epub 2019 Feb 16.

Jesse Brown VA Medical Center, Chicago, IL, 60612, USA; Department of Medicine, University of Illinois, Chicago, IL, 60612, USA. Electronic address:

Brodifacoum (BDF) is a potent, long-acting anticoagulant rodenticide that can cause fatal poisoning in humans. The chemical structure of BDF includes 2 chiral carbons, resulting in 2 pairs of diastereomers, BDF-cis (R/S and S/R) and BDF-trans (R/R and S/S). However, the relative potency of these molecules is not known. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408973PMC
May 2019
12 Reads

Sequential administrations of trifluoroacetate induce tolerance to Palicourea maccgravii, a monofluoroacetate-containing plant, in calves.

Toxicon 2019 Mar 15;160:8-11. Epub 2019 Feb 15.

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil. Electronic address:

Monofluoroacetate (MFA) is considered one of the most toxic substances known. It is found naturally in plants, and causes sudden death syndrome in ruminants. Due to hyperacute evolution of poisoning and the absence of effective treatment, induction of resistance in animals might be the best tool to control MFA poisoning in ruminants. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.02.005DOI Listing
March 2019
4 Reads

Harnessing the catabolic versatility of Gordonia species for detoxifying pollutants.

Biotechnol Adv 2019 May - Jun;37(3):382-402. Epub 2019 Feb 13.

Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune 411007, India; Department of Microbiology, Savitribai Phule Pune University, Pune 411007, India. Electronic address:

The genus Gordonia includes variedly pigmented aerobic, non-motile, non-sporulating Gram positive (sometimes variable) coccoid forms and rods. Different isolates display distinguishing physiological traits and biochemical properties that are significant in remediation applications. Strains inherently prevalent in soils, seawater, sediments and wastewaters can degrade hydrocarbons. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.004DOI Listing
July 2019
6 Reads

Phosphine poisoning in free-range local chickens: a case report.

Vet Med Sci 2018 08 14;4(3):263-268. Epub 2018 Mar 14.

Toxicology Section, Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria.

Phosphine poisoning is rarely reported in poultry, and its diagnosis is a great challenge for veterinary toxicologists and pathologists. A case of phosphine toxicosis in local, free range chickens is reported. Fourteen dead chickens (age ≥6 months old) were presented to the veterinary clinic for necropsy. Read More

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http://doi.wiley.com/10.1002/vms3.100
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http://dx.doi.org/10.1002/vms3.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090409PMC
August 2018
43 Reads

Use of blood clotting assays to assess potential anticoagulant rodenticide exposure and effects in free-ranging birds of prey.

Sci Total Environ 2019 Mar 3;657:1205-1216. Epub 2018 Dec 3.

Environment and Climate Change Canada, Science & Technology Branch, Pacific Wildlife Research Centre, Delta V4K 3N2, BC, Canada. Electronic address:

Non-target wildlife, particularly birds of prey, are widely exposed to and acutely poisoned by anticoagulant rodenticides (ARs). An unresolved issue surrounding such exposure, however, is the potential for sublethal effects. In particular, the consequences of AR exposure and resulting coagulopathy on health and survival of unintentionally exposed animals, which often encounter a multitude of anthropogenic stressors, are understudied. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.485DOI Listing
March 2019
9 Reads

Exposure of non-target small mammals to anticoagulant rodenticide during chemical rodent control operations.

Environ Sci Pollut Res Int 2019 Feb 7;26(6):6133-6140. Epub 2019 Jan 7.

Department of Bioscience, Aarhus University, Grenåvej 14, DK-8410, Rønde, Denmark.

The extensive use of anticoagulant rodenticides (ARs) results in widespread unintentional exposure of non-target rodents and secondary poisoning of predators despite regulatory measures to manage and reduce exposure risk. To elucidate on the potential vectoring of ARs into surrounding habitats by non-target small mammals, we determined bromadiolone prevalence and concentrations in rodents and shrews near bait boxes during an experimental application of the poison for 2 weeks. Overall, bromadiolone was detected in 12. Read More

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http://dx.doi.org/10.1007/s11356-018-04064-3DOI Listing
February 2019
4 Reads

Genetic modification of western wheatgrass (Pascopyrum smithii) for the phytoremediation of RDX and TNT.

Planta 2019 Apr 28;249(4):1007-1015. Epub 2018 Nov 28.

Department of Civil and Environmental Engineering, University of Washington, Box 355014, Seattle, WA, 98195-5014, USA.

Main Conclusion: Transgenic western wheatgrass degrades the explosive RDX and detoxifies TNT. Contamination, from the explosives, hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine (RDX), and 2, 4, 6-trinitrotoluene (TNT), especially on live-fire training ranges, threatens environmental and human health. Phytoremediation is an approach that could be used to clean-up explosive pollution, but it is hindered by inherently low in planta RDX degradation rates, and the high phytotoxicity of TNT. Read More

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http://link.springer.com/10.1007/s00425-018-3057-9
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http://dx.doi.org/10.1007/s00425-018-3057-9DOI Listing
April 2019
36 Reads

Toxicity of the different vegetative stages of Amorimia pubiflora to sheep.

Toxicon 2019 Feb 22;158:47-50. Epub 2018 Nov 22.

Laboratório de Patologia Clínica Veterinária, FAMEZ, UFMS, Av. Senador Felinto Muller, 2443, Campo Grande, MS, 79070-900, Campo Grande, MS, Brazil. Electronic address:

Toxic plants containing monofluoroacetate (MFA) cause sudden death in livestock in Australia, South Africa and Brazil, causing economic losses to producers. The objective of this study was to determine the amount of MFA present in young leaves, mature leaves, senescent leaves, and seeds of Amorimia pubiflora harvested at different times of the year and to determine their toxic effect on sheep. Samples of Amorimia pubiflora were collected during April, August and December of 2015 and March of 2016, separated according to the vegetative stage (young leaves, seeds, mature leaves, and senescent leaves), dried in an oven, and administered in daily doses of 5 g/kg/body weight (bw) of fresh leaves to sheep through ruminal cannulae. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.11.306DOI Listing
February 2019
21 Reads

Characterization of ADME genes variation in Roma and 20 populations worldwide.

PLoS One 2018 19;13(11):e0207671. Epub 2018 Nov 19.

Institute for Anthropological Research, Zagreb, Croatia.

The products of the polymorphic ADME genes are involved in Absorption, Distribution, Metabolism, and Excretion of drugs. The pharmacogenetic data have been studied extensively due to their clinical importance in the appropriate drug prescription, but such data from the isolated populations are rather scarce. We analyzed the distribution of 95 polymorphisms in 31 core ADME genes in 20 populations worldwide and in newly genotyped samples from the Roma (Gypsy) population living in Croatia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207671PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242375PMC
April 2019
14 Reads

Urbanization and cattle density are determinants in the exposure to anticoagulant rodenticides of non-target wildlife.

Environ Pollut 2019 Jan 25;244:801-808. Epub 2018 Oct 25.

Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC, UCLM, JCCM), Ronda de Toledo 12, 13005, Ciudad Real, Spain. Electronic address:

The persistence and toxicity of second generation anticoagulant rodenticides (SGARs) in animal tissues make these compounds dangerous by biomagnification in predatory species. Here we studied the levels of SGARs in non-target species of wildlife and the environmental factors that influence such exposure. Liver samples of terrestrial vertebrates (n = 244) found dead between 2007 and 2016 in the region of Aragón (NE Spain) were analysed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183231
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http://dx.doi.org/10.1016/j.envpol.2018.10.101DOI Listing
January 2019
27 Reads

The research of synthesis and bioactivity of the novel indanedione anticoagulant rodenticides.

Environ Sci Pollut Res Int 2019 May 30;26(14):13833-13838. Epub 2018 Oct 30.

College of Science, Northeastern University, Shenyang, 110819, People's Republic of China.

Three new anticoagulant rodenticides R, R, and R were designed. The containing fluorine acute toxicity groups was added to 1,3-indandione derivative. Analysis method of synthesized anticoagulant rodenticides were IR, H NMR. Read More

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http://dx.doi.org/10.1007/s11356-018-3539-0DOI Listing
May 2019
14 Reads

Anticoagulant rodenticide toxicosis causing tracheal collapse in 4 small breed dogs.

J Vet Emerg Crit Care (San Antonio) 2018 Nov 7;28(6):573-578. Epub 2018 Oct 7.

Department of Clinical Studies-Philadelphia, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Michigan State University College of Veterinary Medicine, Philadelphia, PA, 19104 (Thomer), East Lansing, MI, 48824 (Santoro Beer).

Objective: To describe 4 cases of tracheal narrowing attributed to tracheal mucosal hemorrhage caused by anticoagulant rodenticide toxicity in breeds predisposed to tracheal collapse.

Case Summary: Over the years 2005-2014, 4 dogs were presented for respiratory distress secondary to diffuse tracheal narrowing. All dogs had possible anticoagulant rodenticide ingestion and prolonged prothrombin time. Read More

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http://doi.wiley.com/10.1111/vec.12774
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http://dx.doi.org/10.1111/vec.12774DOI Listing
November 2018
31 Reads

Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS).

Drug Metab Pharmacokinet 2018 Dec 22;33(6):258-263. Epub 2018 Aug 22.

Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. Electronic address:

Genetic polymorphisms contribute to inter-individual variability in the metabolism of multiple clinical drugs, including warfarin, thiopurines, primaquine, and aminoglycosides. A rapid and sensitive clinical assessment of various genome biomarkers is, therefore, required to predict the individual responsiveness of each patient to these drugs. In this study, we developed a novel genotyping method for the detection of nine pharmacogene variants that are important in the prediction of drug efficiency and toxicity. Read More

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http://dx.doi.org/10.1016/j.dmpk.2018.08.003DOI Listing
December 2018
41 Reads

Investigating spatial patterns of mercury and rodenticide residues in raptors collected near the Charlotte, NC, USA, metropolitan area.

Environ Sci Pollut Res Int 2018 Nov 25;25(33):33153-33161. Epub 2018 Sep 25.

Chemistry Department, Davidson College, Davidson, NC, USA.

Raptor population growth is dynamic and trends vary across species and by location in the United States. For those species that are declining, it is important to identify potential causes including chemical contaminants. Sampling wild raptors is problematic due to their small population sizes and role as a top predator. Read More

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http://dx.doi.org/10.1007/s11356-018-3229-yDOI Listing
November 2018
9 Reads

Characteristics of patients with thromboembolic disorders on warfarin therapy in resource limited settings.

BMC Health Serv Res 2018 Sep 19;18(1):723. Epub 2018 Sep 19.

Department of Pharmacology and Toxicology, Moi University School of Medicine, P.O. Box 4606, Eldoret, 30100, Kenya.

Background: Warfarin is a drug with narrow therapeutic index used in the management of thromboembolic disorders. Several factors affect its plasma concentrations with a resultant risk of toxicity. We examined the database of patients on warfarin therapy in order to establish the factors that affect the stability of INR and correlated them to clinical outcomes in resource limited settings. Read More

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http://dx.doi.org/10.1186/s12913-018-3537-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145184PMC
September 2018
11 Reads
1.659 Impact Factor

Do bromadiolone treatments to control grassland water voles (Arvicola scherman) affect small mustelid abundance?

Pest Manag Sci 2019 Apr 16;75(4):900-907. Epub 2018 Oct 16.

Laboratoire Chrono-environnement (UMR 6249), Centre National de la Recherche Scientifique, CNRS, Université Bourgogne Franche-Comté, UBFC, Besançon, France.

Background: The use of pesticides can affect non-target species by causing population declines through indirect intoxication. Small mustelids (SMs; weasels, Mustela nivalis L.; stoats, Mustela erminea L. Read More

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http://dx.doi.org/10.1002/ps.5194DOI Listing
April 2019
20 Reads

Common Rodenticide Toxicoses in Small Animals.

Vet Clin North Am Small Anim Pract 2018 Nov 31;48(6):1027-1038. Epub 2018 Aug 31.

ASPCA Animal Poison Control Center, 1717 South Philo Road, Suite 36, Urbana, IL 61802, USA. Electronic address:

This article focuses on the 3 most commonly used rodenticide types: anticoagulants, bromethalin, and cholecalciferol. It is important to verify the active ingredient in any rodenticide exposure. Many owners use the term D-con to refer to any rodenticide regardless of the brand or type of rodenticide. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.06.006DOI Listing
November 2018
18 Reads

Tetramethylenedisulfotetramine: A Health Risk Compound and a Potential Chemical Warfare Agent.

Toxics 2018 Aug 22;6(3). Epub 2018 Aug 22.

Biomedical Research Center, University Hospital Hradec Kralove, 500 03 Hradec Kralove, Czech Republic.

Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Read More

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http://www.mdpi.com/2305-6304/6/3/51
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http://dx.doi.org/10.3390/toxics6030051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160919PMC
August 2018
51 Reads

The stereoisomerism of second generation anticoagulant rodenticides: a way to improve this class of molecules to meet the requirements of society?

Pest Manag Sci 2019 Apr 15;75(4):887-892. Epub 2018 Sep 15.

USC 1233 RS2GP, VetAgro Sup, INRA, Univ Lyon, Marcy l'Etoile, France.

Second generation anticoagulant rodenticides (SGAR) are generally highly efficient for rodent management even towards warfarin-resistant rodents. Nevertheless, because of their long tissue-persistence, they are very associated with non-target exposure of wildlife and have been identified as 'Candidates for Substitution' by the European Union's competent authority. A promising way to reduce ecotoxicity issues associated to SGAR could be the improvement of SGAR based on their stereoisomery, and due to this improvement, positioning about SGAR might be reconsidered. Read More

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http://dx.doi.org/10.1002/ps.5155DOI Listing
April 2019
12 Reads

The effects of continuous diazinon exposure on growth and reproduction in Japanese medaka using a modified Medaka Extended One Generation Reproduction Test (MEOGRT).

Ecotoxicol Environ Saf 2018 Oct 14;162:438-445. Epub 2018 Jul 14.

US Environmental Protection Agency, Mid-Continent Ecology Division (USEPA MED), 6201 Congdon Blvd, Duluth, MN 55804, USA.

The Medaka Extended One Generation Reproduction Test (MEOGRT) is a Tier 2 test within U.S. Environmental Protection Agency's (USEPA) Endocrine Disruptor Screening Program (EDSP), designed to characterize the potential adverse effects to fish of exposure to chemical that can cause disruption of the endocrine system. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.06.088DOI Listing
October 2018
8 Reads

Pesticide-Poisoned Patients: Can They Be Used as Potential Organ Donors?

J Med Toxicol 2018 Dec 9;14(4):278-282. Epub 2018 Jul 9.

General Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Introduction: The gap between the number of patients on transplant waiting lists and patients receiving transplants is growing. Use of organs from donors who have died following pesticide exposure remains controversial. This study reviews the literature related to transplantation from this group. Read More

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http://dx.doi.org/10.1007/s13181-018-0673-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242794PMC
December 2018
39 Reads

Multiple episodes of 1080 (sodium monofluoroacetate) intoxication in a California calf-raising operation.

J Vet Diagn Invest 2018 Sep 5;30(5):747-751. Epub 2018 Jul 5.

California Animal Health and Food Safety Laboratory System (Adaska, Blanchard, Poppenga), School of Veterinary Medicine, University of California, Davis, CA.

Over a 1-y period, a California calf-raising operation experienced 4 separate episodes of sudden death in 4-6-mo-old steers. Each episode occurred in 1-3 contiguous pens on 1 of 3 properties owned by the operation, but eventually all 3 properties were involved. In each episode, animals appeared normal at the evening feeding but at the subsequent morning feeding were found dead or dying. Read More

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http://dx.doi.org/10.1177/1040638718781435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505786PMC
September 2018
12 Reads

'Toxic' ST elevation.

BMJ Case Rep 2018 Jun 27;2018. Epub 2018 Jun 27.

Department of Cardiac Electrophysiology and Pacing, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1136/bcr-2017-221457DOI Listing
June 2018
12 Reads

Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion.

Pestic Biochem Physiol 2018 Jun 1;148:42-49. Epub 2018 Apr 1.

Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan. Electronic address:

Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition by rodenticides results in lethal hemorrhage in rodents. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.03.018DOI Listing
June 2018
13 Reads

Warfarin, but not rivaroxaban, promotes the calcification of the aortic valve in ApoE-/- mice.

Cardiovasc Ther 2018 Aug 28;36(4):e12438. Epub 2018 Jun 28.

ORAS Rehabilitation Hospital, Motta di Livenza, Treviso, Italy.

Introduction: Vitamin K antagonists, such as warfarin, are known to promote arterial calcification through blockade of gamma-carboxylation of Matrix-Gla-Protein. It is currently unknown whether other oral anticoagulants such as direct inhibitors of Factor Xa can have protective effects on the progression of aortic valve calcification.

Aims: To compare the effect of warfarin and rivaroxaban on the progression of aortic valve calcification in atherosclerotic mice. Read More

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http://doi.wiley.com/10.1111/1755-5922.12438
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http://dx.doi.org/10.1111/1755-5922.12438DOI Listing
August 2018
32 Reads

Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.

Kidney Int 2018 07 30;94(1):102-113. Epub 2018 Apr 30.

Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address:

Chronic kidney disease (CKD) causes dysregulation of mineral metabolism, vascular calcification and renal osteodystrophy, an entity called 'CKD-Mineral and Bone Disorder' (CKD-MBD). Here we determine whether metformin, an anti-diabetic drug, exerts favorable effects on progressive, severe CKD and concomitant mineral metabolism disturbances. Rats with CKD-MBD, induced by a 0. Read More

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http://dx.doi.org/10.1016/j.kint.2018.01.027DOI Listing
July 2018
52 Reads