909 results match your criteria Toxicity Rodenticide


Phosphine poisoning in free-range local chickens: a case report.

Vet Med Sci 2018 Aug 14;4(3):263-268. Epub 2018 Mar 14.

Toxicology Section, Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria.

Phosphine poisoning is rarely reported in poultry, and its diagnosis is a great challenge for veterinary toxicologists and pathologists. A case of phosphine toxicosis in local, free range chickens is reported. Fourteen dead chickens (age ≥6 months old) were presented to the veterinary clinic for necropsy. Read More

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http://doi.wiley.com/10.1002/vms3.100
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http://dx.doi.org/10.1002/vms3.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090409PMC
August 2018
4 Reads

Use of blood clotting assays to assess potential anticoagulant rodenticide exposure and effects in free-ranging birds of prey.

Sci Total Environ 2019 Mar 3;657:1205-1216. Epub 2018 Dec 3.

Environment and Climate Change Canada, Science & Technology Branch, Pacific Wildlife Research Centre, Delta V4K 3N2, BC, Canada. Electronic address:

Non-target wildlife, particularly birds of prey, are widely exposed to and acutely poisoned by anticoagulant rodenticides (ARs). An unresolved issue surrounding such exposure, however, is the potential for sublethal effects. In particular, the consequences of AR exposure and resulting coagulopathy on health and survival of unintentionally exposed animals, which often encounter a multitude of anthropogenic stressors, are understudied. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.485DOI Listing

Urbanization and cattle density are determinants in the exposure to anticoagulant rodenticides of non-target wildlife.

Environ Pollut 2019 Jan 25;244:801-808. Epub 2018 Oct 25.

Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC, UCLM, JCCM), Ronda de Toledo 12, 13005, Ciudad Real, Spain. Electronic address:

The persistence and toxicity of second generation anticoagulant rodenticides (SGARs) in animal tissues make these compounds dangerous by biomagnification in predatory species. Here we studied the levels of SGARs in non-target species of wildlife and the environmental factors that influence such exposure. Liver samples of terrestrial vertebrates (n = 244) found dead between 2007 and 2016 in the region of Aragón (NE Spain) were analysed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183231
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http://dx.doi.org/10.1016/j.envpol.2018.10.101DOI Listing
January 2019
6 Reads

The research of synthesis and bioactivity of the novel indanedione anticoagulant rodenticides.

Environ Sci Pollut Res Int 2018 Oct 30. Epub 2018 Oct 30.

College of Science, Northeastern University, Shenyang, 110819, People's Republic of China.

Three new anticoagulant rodenticides R, R, and R were designed. The containing fluorine acute toxicity groups was added to 1,3-indandione derivative. Analysis method of synthesized anticoagulant rodenticides were IR, H NMR. Read More

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http://dx.doi.org/10.1007/s11356-018-3539-0DOI Listing
October 2018
5 Reads

Anticoagulant rodenticide toxicosis causing tracheal collapse in 4 small breed dogs.

J Vet Emerg Crit Care (San Antonio) 2018 Nov 7;28(6):573-578. Epub 2018 Oct 7.

Department of Clinical Studies-Philadelphia, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Michigan State University College of Veterinary Medicine, Philadelphia, PA, 19104 (Thomer), East Lansing, MI, 48824 (Santoro Beer).

Objective: To describe 4 cases of tracheal narrowing attributed to tracheal mucosal hemorrhage caused by anticoagulant rodenticide toxicity in breeds predisposed to tracheal collapse.

Case Summary: Over the years 2005-2014, 4 dogs were presented for respiratory distress secondary to diffuse tracheal narrowing. All dogs had possible anticoagulant rodenticide ingestion and prolonged prothrombin time. Read More

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http://doi.wiley.com/10.1111/vec.12774
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http://dx.doi.org/10.1111/vec.12774DOI Listing
November 2018
13 Reads

Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS).

Drug Metab Pharmacokinet 2018 Dec 22;33(6):258-263. Epub 2018 Aug 22.

Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. Electronic address:

Genetic polymorphisms contribute to inter-individual variability in the metabolism of multiple clinical drugs, including warfarin, thiopurines, primaquine, and aminoglycosides. A rapid and sensitive clinical assessment of various genome biomarkers is, therefore, required to predict the individual responsiveness of each patient to these drugs. In this study, we developed a novel genotyping method for the detection of nine pharmacogene variants that are important in the prediction of drug efficiency and toxicity. Read More

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http://dx.doi.org/10.1016/j.dmpk.2018.08.003DOI Listing
December 2018
5 Reads

Investigating spatial patterns of mercury and rodenticide residues in raptors collected near the Charlotte, NC, USA, metropolitan area.

Environ Sci Pollut Res Int 2018 Nov 25;25(33):33153-33161. Epub 2018 Sep 25.

Chemistry Department, Davidson College, Davidson, NC, USA.

Raptor population growth is dynamic and trends vary across species and by location in the United States. For those species that are declining, it is important to identify potential causes including chemical contaminants. Sampling wild raptors is problematic due to their small population sizes and role as a top predator. Read More

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http://dx.doi.org/10.1007/s11356-018-3229-yDOI Listing
November 2018
2 Reads

Characteristics of patients with thromboembolic disorders on warfarin therapy in resource limited settings.

BMC Health Serv Res 2018 Sep 19;18(1):723. Epub 2018 Sep 19.

Department of Pharmacology and Toxicology, Moi University School of Medicine, P.O. Box 4606, Eldoret, 30100, Kenya.

Background: Warfarin is a drug with narrow therapeutic index used in the management of thromboembolic disorders. Several factors affect its plasma concentrations with a resultant risk of toxicity. We examined the database of patients on warfarin therapy in order to establish the factors that affect the stability of INR and correlated them to clinical outcomes in resource limited settings. Read More

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http://dx.doi.org/10.1186/s12913-018-3537-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145184PMC
September 2018
1 Read
1.659 Impact Factor

Common Rodenticide Toxicoses in Small Animals.

Vet Clin North Am Small Anim Pract 2018 Nov 31;48(6):1027-1038. Epub 2018 Aug 31.

ASPCA Animal Poison Control Center, 1717 South Philo Road, Suite 36, Urbana, IL 61802, USA. Electronic address:

This article focuses on the 3 most commonly used rodenticide types: anticoagulants, bromethalin, and cholecalciferol. It is important to verify the active ingredient in any rodenticide exposure. Many owners use the term D-con to refer to any rodenticide regardless of the brand or type of rodenticide. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.06.006DOI Listing
November 2018
11 Reads

Tetramethylenedisulfotetramine: A Health Risk Compound and a Potential Chemical Warfare Agent.

Toxics 2018 Aug 22;6(3). Epub 2018 Aug 22.

Biomedical Research Center, University Hospital Hradec Kralove, 500 03 Hradec Kralove, Czech Republic.

Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Read More

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http://www.mdpi.com/2305-6304/6/3/51
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http://dx.doi.org/10.3390/toxics6030051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160919PMC
August 2018
15 Reads

The effects of continuous diazinon exposure on growth and reproduction in Japanese medaka using a modified Medaka Extended One Generation Reproduction Test (MEOGRT).

Ecotoxicol Environ Saf 2018 Oct 14;162:438-445. Epub 2018 Jul 14.

US Environmental Protection Agency, Mid-Continent Ecology Division (USEPA MED), 6201 Congdon Blvd, Duluth, MN 55804, USA.

The Medaka Extended One Generation Reproduction Test (MEOGRT) is a Tier 2 test within U.S. Environmental Protection Agency's (USEPA) Endocrine Disruptor Screening Program (EDSP), designed to characterize the potential adverse effects to fish of exposure to chemical that can cause disruption of the endocrine system. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.06.088DOI Listing
October 2018
2 Reads

Pesticide-Poisoned Patients: Can They Be Used as Potential Organ Donors?

J Med Toxicol 2018 Dec 9;14(4):278-282. Epub 2018 Jul 9.

General Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Introduction: The gap between the number of patients on transplant waiting lists and patients receiving transplants is growing. Use of organs from donors who have died following pesticide exposure remains controversial. This study reviews the literature related to transplantation from this group. Read More

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http://dx.doi.org/10.1007/s13181-018-0673-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242794PMC
December 2018
15 Reads

Multiple episodes of 1080 (sodium monofluoroacetate) intoxication in a California calf-raising operation.

J Vet Diagn Invest 2018 Sep 5;30(5):747-751. Epub 2018 Jul 5.

California Animal Health and Food Safety Laboratory System (Adaska, Blanchard, Poppenga), School of Veterinary Medicine, University of California, Davis, CA.

Over a 1-y period, a California calf-raising operation experienced 4 separate episodes of sudden death in 4-6-mo-old steers. Each episode occurred in 1-3 contiguous pens on 1 of 3 properties owned by the operation, but eventually all 3 properties were involved. In each episode, animals appeared normal at the evening feeding but at the subsequent morning feeding were found dead or dying. Read More

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http://dx.doi.org/10.1177/1040638718781435DOI Listing
September 2018
6 Reads

'Toxic' ST elevation.

BMJ Case Rep 2018 Jun 27;2018. Epub 2018 Jun 27.

Department of Cardiac Electrophysiology and Pacing, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1136/bcr-2017-221457DOI Listing
June 2018
1 Read

Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion.

Pestic Biochem Physiol 2018 Jun 1;148:42-49. Epub 2018 Apr 1.

Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan. Electronic address:

Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition by rodenticides results in lethal hemorrhage in rodents. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.03.018DOI Listing
June 2018
2 Reads

Warfarin, but not rivaroxaban, promotes the calcification of the aortic valve in ApoE-/- mice.

Cardiovasc Ther 2018 Aug 28;36(4):e12438. Epub 2018 Jun 28.

ORAS Rehabilitation Hospital, Motta di Livenza, Treviso, Italy.

Introduction: Vitamin K antagonists, such as warfarin, are known to promote arterial calcification through blockade of gamma-carboxylation of Matrix-Gla-Protein. It is currently unknown whether other oral anticoagulants such as direct inhibitors of Factor Xa can have protective effects on the progression of aortic valve calcification.

Aims: To compare the effect of warfarin and rivaroxaban on the progression of aortic valve calcification in atherosclerotic mice. Read More

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http://doi.wiley.com/10.1111/1755-5922.12438
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http://dx.doi.org/10.1111/1755-5922.12438DOI Listing
August 2018
16 Reads

Anticoagulant rodenticide use, non-target impacts and regulation: A case study from Australia.

Sci Total Environ 2018 Sep 18;634:1372-1384. Epub 2018 Apr 18.

School of Science, Edith Cowan University, 100 Joondalup Drive, Joondalup, Western Australia 6027, Australia. Electronic address:

The impacts of anticoagulant rodenticides (ARs) on non-target wildlife have been well documented in Europe and North America. While these studies are informative, patterns of non-target poisoning of wildlife elsewhere in the world may differ substantially from patterns occurring in Australia and other countries outside of cool temperate regions due to differences in the types of ARs used, patterns of use, legislation governing sales, and potential pathways of secondary exposure. Most of these differences suggest that the extent and severity of AR poisoning in wildlife may be greater in Australia than elsewhere in the world. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.04.069DOI Listing
September 2018
3 Reads

Inspective and toxicological survey of the poisoned baits and bites.

Forensic Sci Int 2018 Jun 31;287:108-112. Epub 2018 Mar 31.

Istituto Zooprofilattico Sperimentale del Mezzogiorno, via Salute 2, 80055, Portici, Napoli, Italy.

Cases of intentional animal poisonings are still widespread in Italy, even if the improper or malicious use of poisoned baits is banned. This represents a serious threat to pets as well as wildlife species, but also an environmental and human health concern. A retrospective study was performed based on baits sent for toxicological analysis to the laboratories of Istituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM) in Southern Italy over a five year period. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.03.038DOI Listing
June 2018
7 Reads

Liquid chromatography with alkylammonium formate ionic liquid mobile phases and fluorescence detection.

J Chromatogr A 2018 Jul 14;1559:128-135. Epub 2018 Mar 14.

Department of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH, 45056, United States.

Fluorescence detection of various pharmaceuticals and the amino acid tryptophan (low molecular weight organic compounds) as well as the enzyme lactate dehydrogenase LDH (high molar mass compound) has been studied in aqueous solutions using alkyl ammonium formate ionic liquids as the primary solvent component. It was expected that the high viscosity of such ionic liquid-water mixtures would enhance fluorescence. Pharmaceuticals such as riboflavin and naproxen showed no such enhancement in the presence of ethylammonium formate (EAF) or isopropylammonium formate (IPAF) but the fluorescence of warfarin was substantially enhanced by a factor of 4 with 80% EAF and a factor of 7 with 70% IPAF. Read More

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http://dx.doi.org/10.1016/j.chroma.2018.03.020DOI Listing
July 2018
11 Reads

Developmental and sex differences in tetramethylenedisulfotetramine (TMDT)-induced syndrome in rats.

Dev Neurobiol 2018 Apr 14;78(4):403-416. Epub 2018 Feb 14.

Department of Public Health, Division of Environmental Health Science, School of Health Sciences and Practice, New York Medical College, Valhalla, New York.

Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide considered a chemical threat agent. Symptoms of intoxication include seizures leading to status epilepticus and death. While children and women have been often the victims, no studies exist investigating the neurotoxic effects of TMDT in developing individuals or females. Read More

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http://dx.doi.org/10.1002/dneu.22582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867264PMC
April 2018
36 Reads

A multicenter, prospective study evaluating the impact of the clinical pharmacist-physician counselling on warfarin therapy management in Lebanon.

BMC Health Serv Res 2018 02 1;18(1):80. Epub 2018 Feb 1.

Saint-Joseph University, Faculty of Pharmacy, Beirut, Lebanon.

Background: Health care professionals (HCP) are known key elements of effective patient's counselling and education. For patients taking warfarin, education about the dose, side effects, and toxicity is clearly identified as a cornerstone of achieving improved health and quality of life. The study objective was to evaluate the patients' knowledge about warfarin and assess the impact of the health care professionals' counselling in enhancing patients' knowledge in achieving warfarin therapeutic outcomes. Read More

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http://dx.doi.org/10.1186/s12913-018-2874-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796596PMC
February 2018
3 Reads
1.659 Impact Factor

Phosphine Analysis in Postmortem Specimens Following Inhalation of Phosphine: Fatal Aluminum Phosphide Poisoning in Children.

J Anal Toxicol 2018 Jun;42(5):330-336

Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Guangfu Xi Road 1347, Shanghai 200063, China.

Phosphine is an insecticide for the fumigation of grains, animal feed, and leaf-stored tobacco, and it was used as a rodenticide in bulk grain stores. Phosphine poisoning may occur after accidental inhalation of phosphine, sometimes leading to death. Analysis of phosphine and its metabolites in postmortem specimens from seven fatal cases was conducted in this study, as well as postmortem specimens collected from rabbits exposed to phosphine. Read More

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http://dx.doi.org/10.1093/jat/bky005DOI Listing
June 2018
49 Reads

Urbanization and anticoagulant poisons promote immune dysfunction in bobcats.

Proc Biol Sci 2018 01;285(1871)

Departments of Pediatrics and Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA.

Understanding how human activities influence immune response to environmental stressors can support biodiversity conservation across increasingly urbanizing landscapes. We studied a bobcat () population in urban southern California that experienced a rapid population decline from 2002-2005 due to notoedric mange. Because anticoagulant rodenticide (AR) exposure was an underlying complication in mange deaths, we aimed to understand sublethal contributions of urbanization and ARs on 65 biochemical markers of immune and organ function. Read More

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http://dx.doi.org/10.1098/rspb.2017.2533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805946PMC
January 2018
6 Reads

The N-terminal-truncated recombinant fibrin(ogen)olytic serine protease improves its functional property, demonstrates in vivo anticoagulant and plasma defibrinogenation activity as well as pre-clinical safety in rodent model.

Int J Biol Macromol 2018 May 29;111:462-474. Epub 2017 Dec 29.

Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur 784028, Assam, India. Electronic address:

An N-terminal truncated fibrino(geno)lytic serine protease gene encoding a ~42kDa protein from Bacillus cereus strain AB01 was produced by error prone PCR, cloned into pET19b vector, and expressed in E5 coli BL21 DE3 cells. The deletion of 24 amino acid residues from N-terminal of wild-type Bacifrinase improves the catalytic activity of [Bacifrinase (ΔN24)]. The anticoagulant potency of [Bacifrinase (ΔN24)] was comparable to Nattokinase and Warfarin and results showed that its anticoagulant action is contributed by progressive defibrinogenation and antiplatelet activities. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2017.12.140DOI Listing
May 2018
8 Reads

The physiology and toxicology of acute inhalation phosphine poisoning in conscious male rats.

Inhal Toxicol 2017 09 18;29(11):494-505. Epub 2017 Dec 18.

a Medical Toxicology Research Division , US Army Medical Research Institute of Chemical Defense , Aberdeen Proving Ground , MD , USA.

Phosphine (PH) is a toxidrome-spanning chemical that is widely used as an insecticide and rodenticide. Exposure to PH causes a host of target organ and systemic effects, including oxidative stress, cardiopulmonary toxicity, seizure-like activity and overall metabolic disturbance. A custom dynamic inhalation gas exposure system was designed for the whole-body exposure of conscious male Sprague-Dawley rats (250-350 g) to PH. Read More

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http://dx.doi.org/10.1080/08958378.2017.1406564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309866PMC
September 2017
9 Reads

[Evaluation of Brodifacoum-induced Toxicity by Metabonomics Approach Based on HPLC-TOF-MS].

Fa Yi Xue Za Zhi 2017 Jun 25;33(3):247-251. Epub 2017 Jun 25.

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, PRC, Shanghai 200063, China.

Objectives: To analyse the metabolic changes in urine of rats with brodifacoum intoxication, and to reveal the molecular mechanism of brodifacoum-induced toxicity on rats.

Methods: By establishing a brodifacoum poisoning rats model, the urine metabolic profiling data of rats were acquired using high performance liquid chromatography-time of flight mass spectrometry (HPLC-TOF-MS). The orthogonal partial least squares analysis-discrimination analysis (OPLS-DA) was applied for the multivariate statistics and the discovery of differential metabolites closely related to toxicity of brodifacoum. Read More

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http://dx.doi.org/10.3969/j.issn.1004-5619.2017.03.007DOI Listing
June 2017
1 Read

GABA receptor subtype selectivity of the proconvulsant rodenticide TETS.

Arch Toxicol 2018 Feb 16;92(2):833-844. Epub 2017 Oct 16.

Department of Pharmacology, Genome and Biomedical Sciences Facility Room 3502, 451 Health Sciences Drive, School of Medicine, University of California, Davis, CA, 95616, USA.

The rodenticide tetramethylenedisulfotetramine (TETS) is a potent convulsant (lethal dose in humans 7-10 mg) that is listed as a possible threat agent by the United States Department of Homeland Security. TETS has previously been studied in vivo for toxicity and in vitro in binding assays, with the latter demonstrating it to be a non-competitive antagonist on GABA receptors. To determine whether TETS exhibits subtype selectivity for a particular GABA receptor combination, we used whole-cell patch-clamp to determine the potency of TETS on the major synaptic and extrasynaptic GABA receptors associated with convulsant activity. Read More

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http://dx.doi.org/10.1007/s00204-017-2089-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818616PMC
February 2018
16 Reads

Phenotyping of CYP 4501A2 Activity by Total Overnight Salivary Caffeine Assessment (TOSCA) in Patients on Warfarin Treatment: A Cross-Sectional Study.

Clin Appl Thromb Hemost 2018 Sep 9;24(6):928-935. Epub 2017 Oct 9.

1 Department of Clinical Medicine and Surgery, "Federico II" University, Naples, Italy.

Warfarin is an oral anticoagulant, commonly used for primary and secondary prevention of venous and arterial thromboembolic events. The drug is characterized by narrow therapeutic index, widespread individual variability in clinical response, and high rates of adverse events, particularly bleeding complications. For these reasons, a close monitoring of the dosage, using the frequent assessment of coagulation status by means of International Normalized Ratio value, is mandatory. Read More

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http://dx.doi.org/10.1177/1076029617733040DOI Listing
September 2018
12 Reads

Yellow phosphorus-induced Brugada phenocopy.

J Electrocardiol 2018 Jan - Feb;51(1):129-131. Epub 2017 Sep 1.

Department of General Medicine, Indira Gandhi Medical College & Research Institute, Kathirkamam, Pondicherry 605009, India.

Background: Metallic phosphides (of aluminum and phosphide) and yellow phosphorus are commonly used rodenticide compounds in developing countries. Toxicity of yellow phosphorus mostly pertains to the liver, kidney, heart, pancreas and the brain. Cardiotoxicity with associated Brugada ECG pattern has been reported only in poisoning with metallic phosphides. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2017.08.033DOI Listing
February 2019
19 Reads

TOXIC EXPOSURES IN CHILDREN INVOLVING LEGALLY AND ILLEGALLY COMMERCIALIZED HOUSEHOLD SANITIZERS.

Rev Paul Pediatr 2017 Jan-Mar;35(1):11-17

Faculdade de Enfermagem da UNICAMP, Campinas, SP, Brasil.

Objectives: To analyze and to compare clinical repercussions of accidents involving legally and illegally commercialized household sanitizers in children under 7 years of age.

Methods: A descriptive cross-sectional design was used to collect data from electronic database of a regional Poison Control Center during one year. Data were analyzed by means of descriptive non-parametric statistics and association tests. Read More

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http://dx.doi.org/10.1590/1984-0462/;2017;35;1;00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417804PMC
June 2018
7 Reads

Sodium fluoroacetate toxicity: a case report of malicious poisoning in dogs across a Phoenix, Arizona neighborhood.

Forensic Sci Med Pathol 2017 Dec 3;13(4):450-453. Epub 2017 Oct 3.

Phoenix Police Department, Property Crimes Bureau, Animal Cruelty Investigations, Cave Creek, AZ, USA.

In May 2016, thirteen dogs housed in backyards within a single neighborhood were reported to have developed convulsions and died within a 24 h period. An investigation of the scene by law enforcement resulted in submission of eight dogs for postmortem examination. It was suspected that a rapid acting toxin was the cause of death. Read More

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http://link.springer.com/10.1007/s12024-017-9923-0
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http://dx.doi.org/10.1007/s12024-017-9923-0DOI Listing
December 2017
17 Reads

Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus.

Toxicol Rep 2017 19;4:450-454. Epub 2017 Jul 19.

Karakoram International University, Main Campus University Road, Gilgit, (15100), Pakistan.

Blood is promptly affected by environmental pollutants and toxicants that can cause many metabolic disorders. The high level of fluoride acts as a potential pollutant, insecticide and rodenticide with very high toxicity, associated with the hematological damage. This study aimed to determine the toxicity of Sodium Fluoride on hematological parameters in Oryctolagus cunniculus. Read More

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http://dx.doi.org/10.1016/j.toxrep.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615144PMC
July 2017
11 Reads

Effects of bromadiolone poisoning on the central nervous system.

Neuropsychiatr Dis Treat 2017 30;13:2297-2300. Epub 2017 Aug 30.

Neurology Department, Binzhou Medical University Hospital, Binzhou Medical University.

Cases of rodenticide poisoning (second-generation long-acting dicoumarin rodenticide, superwarfarin) have occasionally been reported. The main symptoms of bromadiolone poisoning are skin mucosa hemorrhage, digestive tract hemorrhage, and hematuresis. However, the symptoms of central nervous system toxicity have rarely been reported. Read More

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http://dx.doi.org/10.2147/NDT.S142375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587214PMC
August 2017
11 Reads

The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats.

Toxicol Sci 2017 09;159(1):224-237

Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612.

Superwarfarins are very long-lasting rodenticides effective in warfarin-resistant rodents at extremely low doses. The consequences of chronic superwarfarin levels in tissues, due to biological half-lives on the order of 20 days, have not been examined. We now characterized the neurological effects of brodifacoum (BDF), one of the most widely used superwarfarins, in adult male Sprague Dawley rats. Read More

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http://dx.doi.org/10.1093/toxsci/kfx134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837443PMC
September 2017
11 Reads

Exposure of stone marten (Martes foina) and polecat (Mustela putorius) to anticoagulant rodenticides: Effects of regulatory restrictions of rodenticide use.

Sci Total Environ 2018 Jan 25;612:1358-1364. Epub 2017 Sep 25.

Department of Bioscience, Aarhus University, Grenåvej 14, DK-8410 Rønde, Denmark. Electronic address:

When anticoagulant rodenticides (ARs) are used to control rodent populations there is also a widespread secondary exposure of non-target predators to ARs. To reduce secondary exposure, regulatory restrictions in AR usage were tightened in Denmark in 2011. The restrictions included the cessation of AR use for plant protection and any use away from buildings, as well as limitations in private consumers' access to ARs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2017.09.034DOI Listing
January 2018
18 Reads

Behavioral intoxication following voluntary oral ingestion of tetramethylenedisulfotetramine: Dose-dependent onset, severity, survival, and recovery.

Neurotoxicology 2017 Dec 7;63:21-32. Epub 2017 Sep 7.

United States Army Medical Research Institute of Chemical Defense, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD, 21010, USA. Electronic address:

Tetramethylenedisulfotetramine (tetramine, or TETS) is a highly toxic rodenticide that has been responsible for over 14,000 accidental and intentional poisonings worldwide. Although the vast majority of TETS poisonings involved tainted food or drink, the laboratory in vivo studies of TETS intoxication used intraperitoneal injection or gavage for TETS exposure. Seeking to develop and characterize a more realistic model of TETS intoxication in the present study, rats were trained to rapidly and voluntarily consume a poisoned food morsel. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X173017
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http://dx.doi.org/10.1016/j.neuro.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683944PMC
December 2017
13 Reads

Accumulation of anticoagulant rodenticides (chlorophacinone, bromadiolone and brodifacoum) in a non-target invertebrate, the slug, Deroceras reticulatum.

Sci Total Environ 2018 Jan 17;610-611:576-582. Epub 2017 Aug 17.

USC1233 INRA-VetAgro-Sup Campus Vétérinaire de Lyon, 1 avenue Bourgelat, 69280 Marcy l'Etoile, France.

Anticoagulant rodenticides (ARs) are used worldwide to control populations of agricultural and urban rodents, but these pesticides may be accumulated in and poisoned non-target species of wildlife. Slugs may feed on rodenticide bait following field applications. Thus, it can be assumed that their predators are exposed to rodenticides through food chain transfer. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2017.08.117DOI Listing
January 2018
9 Reads

Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis.

J Neuroinflammation 2017 07 28;14(1):152. Epub 2017 Jul 28.

Department of Neurology, Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Background: In multiple sclerosis, coagulation factors have been shown to modulate inflammation. In this translational study, we investigated whether long-term anticoagulation with warfarin or rivaroxaban has beneficial effects on the course of autoimmune experimental encephalomyelitis (EAE).

Methods: Female SJL/J mice treated with anticoagulants namely warfarin or rivaroxaban were immunized with PLP. Read More

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http://dx.doi.org/10.1186/s12974-017-0926-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534067PMC
July 2017
4 Reads

Effects of Teicoplanin on the PT-INR Controlled by Warfarin in Infection Patients.

Yakugaku Zasshi 2017 ;137(7):909-916

Department of Pharmacy, Fukuoka University Hospital.

Warfarin (WF) shows a number of interactions with other drugs, which alter its anticoagulant effects. The albumin binding interaction is one such pharmacokinetic mechanism of drug interaction with WF, which induces a rise in the free WF concentration and thus increases the risk of WF toxicity. Teicoplanin (TEIC) is an anti-methicillin-resistant Staphylococcus aureus drug, which also binds strongly to albumin in the plasma. Read More

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http://dx.doi.org/10.1248/yakushi.17-00023DOI Listing
September 2017
23 Reads

Anticoagulant rodenticide exposure and toxicosis in four species of birds of prey in Massachusetts, USA, 2012-2016, in relation to use of rodenticides by pest management professionals.

Authors:
Maureen Murray

Ecotoxicology 2017 Oct 1;26(8):1041-1050. Epub 2017 Jul 1.

Wildlife Clinic, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, 01536, USA.

Restrictions on second-generation anticoagulant rodenticides (SGARs) in the United States, which were partially implemented in 2011, prohibit the sale of SGAR products through general consumer outlets to minimize use by non-professional or non-agricultural applicators. This study analyzed liver tissue from four species of birds of prey admitted to a wildlife clinic in Massachusetts, USA, from 2012-2016 for residues of anticoagulant rodenticides (ARs). Ninety-four birds were analyzed; 16 were symptomatic for AR toxicosis, and 78 asymptomatic. Read More

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http://dx.doi.org/10.1007/s10646-017-1832-1DOI Listing
October 2017
20 Reads

A preliminary review of warfarin toxicity in a tertiary hospital in Cape Town, South Africa.

Cardiovasc J Afr 2017 Nov/Dec 23;28(6):346-349. Epub 2017 May 21.

Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa.

Aim: Warfarin is a widely used anticoagulant for the prevention and treatment of thromboembolism. We conducted a retrospective review to determine the causes and management of warfarin toxicity of patients admitted to Tygerberg hospital between June 2014 and June 2015.

Results: We identified and evaluated 126 patients who met the inclusion criteria. Read More

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http://dx.doi.org/10.5830/CVJA-2017-029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885058PMC
August 2018
5 Reads

Adverse Drug Reactions and Cutaneous Manifestations Associated With Anticoagulation.

J Cutan Med Surg 2017 Nov/Dec;21(6):540-550. Epub 2017 Jun 22.

2 Skin Centre for Dermatology, Peterborough, ON, Canada.

Anticoagulants are amongst the most commonly prescribed medications worldwide. Although rare, localised and systemic drug reactions have been reported with anticoagulants that can lead to significant morbidity and mortality. Some of the first signs of drug reactions to anticoagulants are cutaneous changes that, when recognised early, can prevent significant complications. Read More

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http://dx.doi.org/10.1177/1203475417716364DOI Listing
July 2018
28 Reads

Common explosives (TNT, RDX, HMX) and their fate in the environment: Emphasizing bioremediation.

Chemosphere 2017 Oct 4;184:438-451. Epub 2017 Jun 4.

Gottfried Wilhelm Leibniz Universität Hannover, Institut für Radioökologie und Strahlenschutz (IRS), Herrenhäuser Str. 2, Gebäude 4113, 30419, Hannover, Germany. Electronic address:

Explosive materials are energetic substances, when released into the environment, contaminate by posing toxic hazards to environment and biota. Throughout the world, soils are contaminated by such contaminants either due to manufacturing operations, military activities, conflicts of different levels, open burning/open detonation (OB/OD), dumping of munitions etc. Among different forms of chemical explosives, 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro- 1,3,5,7-tetrazocine (HMX) are most common. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2017.06.008DOI Listing
October 2017
23 Reads

Cis-bromadiolone diastereoisomer is not involved in bromadiolone Red Kite (Milvus milvus) poisoning.

Sci Total Environ 2017 Dec 8;601-602:1412-1417. Epub 2017 Jun 8.

USC 1233 RS2GP, VetAgro Sup, INRA, Univ Lyon, F-69280 Marcy l'Etoile, France.

Anticoagulant rodenticides (ARs) are widely used pesticides to control rodent populations. Bromadiolone, a second generation anticoagulant rodenticide (SGARs), is authorized in France to control the population of water voles (Arvicola scherman). The persistence of SGARs in rodents is responsible for secondary exposure or poisoning of predators and scavengers, and is of ecological concern for the conservation of endangered species. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2017.06.011DOI Listing
December 2017
15 Reads

Upper Airway Obstruction Secondary to Anticoagulant Rodenticide Toxicosis in Five Dogs.

J Am Anim Hosp Assoc 2017 Jul/Aug;53(4):236-241. Epub 2017 May 23.

From the University of Illinois, Urbana, Illinois.

Five dogs were presented with clinical signs compatible with upper airway obstruction, including stridor, stertor, coughing, gagging, and varying degrees of respiratory distress. All dogs had radiographic findings of soft tissue opacity in the area of the pharynx, larynx, or trachea, and several had narrowing of the tracheal lumen. Coagulation abnormalities (prolonged prothrombin time, activated partial thromboplastin time) were present in the four dogs that underwent testing. Read More

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http://dx.doi.org/10.5326/JAAHA-MS-6658DOI Listing
November 2017
9 Reads

Prevention of phosphine-induced cytotoxicity by nutrients in HepG2 cells.

Indian J Med Res 2016 Oct;144(4):560-565

Department of Pharmacology & Toxicology, Faculty of Pharmacy; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background & Objectives: Phosphides used as an insecticide and rodenticide, produce phosphine (PH3) which causes accidental and intentional poisoning cases and deaths. There is no specific treatment or antidote available for PH3poisoning. It is suggested that PH3-induced toxicity is associated with adenosine triphosphate (ATP) depletion; therefore, in this study the effect of some nutrients was evaluated on PH3cytotoxicity in a cell culture model. Read More

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http://dx.doi.org/10.4103/0971-5916.200896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345302PMC
October 2016
6 Reads

[Toxicity for warfarine switching from lopinavir/ritonavir to dolutegravir].

Farm Hosp 2017 03 1;41(2):315-316. Epub 2017 Mar 1.

Servicio de Farmacia, Hospital Lluís Alcanyís de Xàtiva, Valencia..

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http://dx.doi.org/10.7399/fh.2017.41.2.10685DOI Listing
March 2017
1 Read

Apixaban Versus Warfarin for Mechanical Heart Valve Thromboprophylaxis in a Swine Aortic Heterotopic Valve Model.

Arterioscler Thromb Vasc Biol 2017 05 23;37(5):942-948. Epub 2017 Feb 23.

From the Unit for Laboratory Animal Medicine (P.A.L., D.D.M.) and Conrad Jobst Vascular Research Laboratories (P.A.L., D.M.C., J.A.D., T.O.J., A.E.H., A.R.M., B.T.G., T.W.W., D.D.M.), University of Michigan, Ann Arbor; and Global Clinical Research, Research & Development (R.M.K., E.R.) and Exploratory Clinical and Translational Research (C.E.F., Y.S.), Bristol-Myers Squibb Company, Princeton, NJ.

Objective: Warfarin is the current standard for oral anticoagulation therapy in patients with mechanical heart valves, yet optimal therapy to maximize anticoagulation and minimize bleeding complications requires routine coagulation monitoring, possible dietary restrictions, and drug interaction monitoring. As alternatives to warfarin, oral direct acting factor Xa inhibitors are currently approved for the prophylaxis and treatment of venous thromboembolism and reduction of stroke and systemic embolization. However, no in vivo preclinical or clinical studies have been performed directly comparing oral factor Xa inhibitors such as apixaban to warfarin, the current standard of therapy. Read More

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http://dx.doi.org/10.1161/ATVBAHA.116.308649DOI Listing
May 2017
22 Reads
6.000 Impact Factor

[Zinc phosphide poisoning in pediatric patients from a Toxicology Center at Mexico City].

Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S44-S52

Departamento Clínico de Toxicología, Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Background: Zinc phosphide is a chemical compound that is frequently used as a rodenticide; it is a highly toxic product that is widely used, among other spaces, at home. Given that it is a highly commercialized pesticide and that there is no antidote, it is mandatory to establish favorably the clinical manifestations of the intoxication. The aim was to describe the epidemiological and clinical profile of children intoxicated with zinc phosphide attended in a toxicological center of a tertiary referral hospital. Read More

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January 2018
15 Reads