8,969 results match your criteria Toxicity Organophosphate


Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.

J Vet Med Sci 2019 Feb 15. Epub 2019 Feb 15.

The Institute of Environmental Toxicology.

The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC+PARA exposure compared to that of the control, MXC, and PARA groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1292/jvms.18-0641DOI Listing
February 2019

Chlorpyrifos-Induced Delayed Neurotoxicity with A Rare Presentation of Flaccid Quadriplegia: A Diagnostic Challenge.

Eur J Case Rep Intern Med 2018 31;5(1):000751. Epub 2018 Jan 31.

Internal Medicine Department A, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Chlorpyrifos is an organophosphate compound recognized as causing acute toxicity. However, organophosphate-induced delayed polyneuropathy (OPIDP), although rare, has also been described. We describe an unusual presentation of OPIDP with flaccid quadriplegia progressing to a locked-in-like syndrome, 30 days after a 60-year-old man voluntarily ingested chlorpyrifos. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2017_000751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346943PMC
January 2018

Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides.

Acta Naturae 2018 Oct-Dec;10(4):125-128

Institute of Bioorganic Chemistry, Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Miklukho-Maklaya Str., 16/10, Moscow, 117997, Russia.

The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351027PMC
February 2019
1 Read

Immunostimulating effects of Ginkgo biloba extract against toxicity induced by organophosphate pesticide, diazinon in rainbow trout, Oncorhynchus mykiss: innate immunity components and immune-related genes.

Environ Sci Pollut Res Int 2019 Feb 2. Epub 2019 Feb 2.

Department of Fisheries and Environmental Sciences, Faculty of Natural Resources and Earth Sciences, Shahrekord University, Shahrekord, Iran.

The immunostimulating and therapeutic properties of Ginkgo biloba (GB) have always been the focus of traditional medicine over thousands of years. During last decade, special attentions were paid to use of GB in aquaculture to enhance fish health and survival. In the present study, we investigated for the first time the immunogenic effects of dietary GB against oxidative and toxicity induced by organophosphate pesticide, diazinon. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11356-019-04327-7
Publisher Site
http://dx.doi.org/10.1007/s11356-019-04327-7DOI Listing
February 2019
4 Reads

Genotoxic and immunotoxic effects of the organophosphate metabolite diethyldithiophosphate (DEDTP) in Vivo.

Toxicol Appl Pharmacol 2019 Mar 29;366:96-103. Epub 2019 Jan 29.

Toxicology Department, Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. IPN 2508, San Pedro Zacatenco, GA. Madero, Mexico City 07360, Mexico. Electronic address:

Diethyldithiophosphate (DEDTP) is a metabolite produced by the degradation of organophosphorus pesticides and a dialkylphosphate that is chemically synthesized with widespread commercial use. DEDTP is a stable compound, and most studies considered it harmless. However, some studies found adverse effects in vitro, including toxicity in different human cell types. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0041008X193003
Publisher Site
http://dx.doi.org/10.1016/j.taap.2019.01.023DOI Listing
March 2019
2 Reads

Exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) induces vascular toxicity through Nrf2-VEGF pathway in zebrafish and human umbilical vein endothelial cells.

Environ Pollut 2019 Jan 3;247:293-301. Epub 2019 Jan 3.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

The growing production and extensive use of organophosphate flame retardants (OPFRs) have led to an increase in their environmental distribution and human exposure. Developmental toxicity is a major concern of OPFRs' adverse health effects. However, the impact of OPFRs exposure on vascular development and the toxicity pathway for developmental defects are poorly understood. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02697491183502
Publisher Site
http://dx.doi.org/10.1016/j.envpol.2018.12.066DOI Listing
January 2019
8 Reads

OPFRs and BFRs induced A549 cell apoptosis by caspase-dependent mitochondrial pathway.

Chemosphere 2019 Jan 16;221:693-702. Epub 2019 Jan 16.

Key Laboratory of Ministry of Education on Pollution Control and Ecosystem Restoration in Industry Clusters, Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal, School of Environment and Energy, South China University of Technology, Guangzhou, 510006, Guangdong, China.

Organophosphate flame retardants (OPFRs) and brominated flame retardants (BFRs) are frequently detected in indoor environment at high levels, posing health risks to humans. However, the potential cytotoxicity mediated by OPFRs and BFRs in relevant human cell models is limited. In current study, non-small cell lung cancer A549 cell was employed to investigate toxicity mechanisms of typical OPFRs (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.01.074DOI Listing
January 2019
2 Reads

Organophosphite Antioxidants in Indoor Dust Represent an Indirect Source of Organophosphate Esters.

Environ Sci Technol 2019 Feb 4;53(4):1805-1811. Epub 2019 Feb 4.

Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , M5S 3H6 , Ontario Canada.

Precise determination of organophosphate esters (OPEs) in the environment is crucial to estimating their potential toxicity effects on human health. Previous studies have mainly focused on OPEs from direct sources. This study explored a potential indirect source of OPEs: the oxidation of organophosphite antioxidants (OPAs). Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.est.8b05545
Publisher Site
http://dx.doi.org/10.1021/acs.est.8b05545DOI Listing
February 2019
5 Reads

Downregulation of carboxylesterase contributes to cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval).

Pest Manag Sci 2019 Jan 17. Epub 2019 Jan 17.

Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400716, China.

Background: Increased expression or point mutations of carboxyl/cholinesterases (CCEs) have been involved in many cases of insecticides and acaricides resistance. However, it is only rarely documented that down-regulation of CCE genes are associated with resistance, although many insecticides and acaricides need hydrolytic activation in vivo. Previously, expression analysis of a laboratory selected cyflumetofen resistant strain of Tetranychus cinnabarinus indicated that resistance was associated with increased expression of a CCE gene of TcCCE04, but also the down-regulation of two CCE genes, TcCCE12 and TcCCE23. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ps.5339
Publisher Site
http://dx.doi.org/10.1002/ps.5339DOI Listing
January 2019
4 Reads

Organophosphate Ester, 2-Ethylhexyl Diphenyl Phosphate (EHDPP), Elicits Cytotoxic and Transcriptomic Effects in Chicken Embryonic Hepatocytes and Its Biotransformation Profile Compared to Humans.

Environ Sci Technol 2019 Feb 1;53(4):2151-2160. Epub 2019 Feb 1.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.

The effects of 2-ethylhexyl diphenyl phosphate (EHDPP) on cytotoxicity and mRNA expression, as well as its metabolism, were investigated using a chicken embryonic hepatocyte (CEH) assay. After incubation for 36 h, the lethal concentration 50 (LC) was 50 ± 11 μM, suggesting that EHDPP is one of a small cohort of highly toxic organophosphate esters (OPEs). By use of a ToxChip polymerase chain reaction (PCR) array, we report modulation of 6, 11, or 16/43 genes in CEH following exposure to 0. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.est.8b06246
Publisher Site
http://dx.doi.org/10.1021/acs.est.8b06246DOI Listing
February 2019
5 Reads

Protective Effect of N-Acetyl Cysteine on Chlorpyrifos-Induced Testicular Toxicity in Mice.

Int J Fertil Steril 2019 Apr 6;13(1):51-56. Epub 2019 Jan 6.

Department of Clinical Biochemistry, Babol University of Medical Science, Babol, lran.

Background: Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N-Acetyl Cysteine (NAC), a potent antioxidant against testicular toxicity of CPF in male mice. Read More

View Article

Download full-text PDF

Source
http://ijfs.ir/journal/article/abstract/5494
Publisher Site
http://dx.doi.org/10.22074/ijfs.2019.5494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334019PMC
April 2019
11 Reads

The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae.

Chemosphere 2019 Apr 3;220:811-817. Epub 2019 Jan 3.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

Tris (1-chloro-2-propyl) phosphate (TCIPP) and tris (2-chloroethyl)phosphate (TCEP) are two widely used chlorinated organophosphate flame retardants (ClOPFRs), and have been frequently detected in various environmental media. Concern is now growing whether TCIPP and TCEP can cause neurotoxicity since they have similar chemical structure with organophosphorus pesticide. Therefore, in this study, zebrafish embryos (2-120 h post-fertilization [hpf]) were exposed to TCIPP or TCEP (0, 100, 500 or 2500 μg/L) or a model neurotoxicant, chlorpyrifos (CPF, 100 μg/L) to investigate the adverse effects and possible mechanisms of TCIPP and TCEP on neurodevelopment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535183254
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2018.12.198DOI Listing
April 2019
3 Reads
3.340 Impact Factor

Daily temperature variation magnifies the toxicity of a mixture consisting of a chemical pesticide and a biopesticide in a vector mosquito.

Sci Total Environ 2019 Apr 23;659:33-40. Epub 2018 Dec 23.

Laboratory of Evolutionary Stress Ecology and Ecotoxicology, University of Leuven, Belgium. Electronic address:

While many studies on the toxicity of pesticides looked at the effects of a higher mean temperature, effects of the realistic scenario of daily temperature variation are understudied. Moreover, despite the increasing interest for the toxicity of pesticide mixtures how this is influenced by temperature has been largely ignored. We tested whether daily temperature variation (DTV) magnifies the toxicity of two pesticides with a different mode of action, the organophosphate pesticide chlorpyrifos (CPF) and the biopesticide Bacillus thuringiensis var. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.12.332DOI Listing
April 2019
1 Read

Studies on the ameliorative effect of curcumin on carbofuran induced perturbations in the activity of lactate dehydrogenase in wistar rats.

Saudi J Biol Sci 2018 Dec 11;25(8):1585-1592. Epub 2016 Mar 11.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India.

Carbofuran is known to inhibit neurotransmission system of insects. The present study was undertaken to evaluate the possible ameliorative effect of curcumin on carbofuran induced alterations in energy metabolism in brain and liver of rats. The results demonstrate that carbofuran caused a significant inhibition of lactate dehydrogenase (LDH) activity in rat liver but an increase in LDH activity in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sjbs.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303160PMC
December 2018
1 Read

Therapeutic Effect of Adding Magnesium Sulfate in Treatment of Organophosphorus Poisoning.

Open Access Maced J Med Sci 2018 Nov 15;6(11):2051-2056. Epub 2018 Nov 15.

Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran.

Background: In recent years, the prevalence of poisoning has increased dramatically due to population growth and access to drugs and toxins. Today poisoning is one of the important reasons for visiting hospitals.

Aim: The present study aimed to investigate the effect of magnesium sulfate on organophosphorous toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3889/oamjms.2018.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290410PMC
November 2018
1 Read

Are cell phones an indicator of personal exposure to organophosphate flame retardants and plasticizers?

Environ Int 2019 Jan 4;122:104-116. Epub 2018 Dec 4.

Department of Earth Sciences, University of Toronto, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Exposure to organophosphate ester (OPE) flame retardants and plasticizers is widespread and is of concern due to their toxicity.

Objectives: To investigate relationships between and within OPE concentrations in air, dust, hands, electronic product wipes and urinary metabolites with the goal of identifying product sources and exposure pathways.

Methods: Women in Toronto and Ottawa, Canada, provided a urine sample, two sets of hand wipes, access to their homes for air and dust sampling, and completed a questionnaire. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01604120183096
Publisher Site
http://dx.doi.org/10.1016/j.envint.2018.10.021DOI Listing
January 2019
14 Reads

Azinphos-methyl causes in Planorbarius corneus toxic effects on reproduction, offspring survival and B-esterases depending on the exposure time.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 4;217:114-121. Epub 2018 Dec 4.

Laboratorio de Ecotoxicología Acuática: Invertebrados Nativos (EAIN), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428 Buenos Aires, Argentina; Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina. Electronic address:

This work aimed to study in the freshwater gastropod Planorbarius corneus the effects of acute (2 days) and subchronic (14 days) exposures to an environmental concentration of the organophosphate azinphos-methyl on different reproductive parameters, offspring survival and B-esterase activities in gonads and in the whole organism soft tissue. The acute exposure inhibited only carboxylesterase activity in both tissues while the subchronic exposure also inhibited cholinesterase activity, decreased the number of hatched-eggs and increased offspring lethality (92%). On the other hand, B-esterases in gonads were more effective biomarkers than B-esterases in the whole organism due their inhibition appeared earlier in time (cholinesterase activity) and their activity remained inhibited for a longer time (carboxylesterase activity) when recovery studies were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpc.2018.12.002DOI Listing
March 2019
3 Reads

Seasonal variations of tris (2-chloroethyl) phosphate and cytotoxicity of organic extracts in water samples from Wuhan, China.

J Environ Sci (China) 2019 Feb 23;76:299-309. Epub 2018 May 23.

Department of Occupational and Environmental Health, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Tris (2-chloroethyl) phosphate (TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants (DWTPs) in China, and evaluated the cytotoxicity and apoptosis/necrosis of organic extracts (OEs) in water samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jes.2018.05.013DOI Listing
February 2019
2 Reads

A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway.

Pestic Biochem Physiol 2018 Nov 13;152:29-37. Epub 2018 Aug 13.

Sharjah Institute for Medical Research and College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Chlorpyrifos (CPF) is an agricultural pesticide and a potential food contaminant, which causes neurotoxicity. Here, we aimed at exploring the link between the repeated exposure to CPF and memory dysfunction in rats and the possible protective effect of kaempferol, a flavonoid with appreciable antioxidant and anti-inflammatory activities. Rats were divided into: Control group (received drug vehicles for 14 days); CPF-treated group (received subcutaneous 18 mg/kg BW of CPF daily for 14 days and CPF + Kaempferol treated group (received the same CPF dose +21 mg/kg BW of Kaempferol intraperitoneally for 14 days. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00483575183010
Publisher Site
http://dx.doi.org/10.1016/j.pestbp.2018.08.008DOI Listing
November 2018
2 Reads
2.014 Impact Factor

Gonadal impairment and parental transfer of tris (2-butoxyethyl) phosphate in zebrafish after long-term exposure to environmentally relevant concentrations.

Chemosphere 2019 Mar 22;218:449-457. Epub 2018 Nov 22.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tris (2-butoxyethyl) phosphate (TBOEP) is a ubiquitous environmental contaminant due to its overuse. TBOEP has been found to cause reproductive toxicity and endocrine disruption during acute toxic experiment. In this study, we examined the effects of TBOEP on growth in initial generation (F0) zebrafish and transgenerational effects on growth of first generation (F1) larvae after parental long-term exposure (120 d) to environmentally relevant concentrations (0, 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.11.139DOI Listing
March 2019
2 Reads

Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.

Toxicol Sci 2018 Dec;166(2):420-427

Center for Environmental Health Sciences.

The nerve agents are extremely toxic organophosphates which lead to massive inhibition of acetylcholinesterase (AChE) in both the central and peripheral nervous systems. The currently approved pyridinium oxime reactivators of organophosphate-inhibited AChE (eg, 2-PAM in the United States) cannot penetrate the blood-brain barrier because of the permanent positive charge in the pyridinium ring. Therefore these current oximes cannot rescue inhibited AChE in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfy212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260155PMC
December 2018
3 Reads

Ecotoxicity response of chlorpyrifos in Aedes aegypti larvae and Lactuca sativa seeds after UV/HO and UVC oxidation.

Ecotoxicol Environ Saf 2019 Mar 22;169:449-456. Epub 2018 Nov 22.

Federal University of Technology - Paraná, Brazil. Electronic address:

Chlorpyrifos (CP) is an organophosphate pesticide widely used in agriculture known to cause neurological and immunological effects in addition to interfering in the reproduction and development of organisms. In this study, CP degradation by UV/HO process and UVC radiation was investigated, and the ecotoxicity and phytotoxicity was evaluated using bioassays of Aedes aegypti larvae and Lactuca sativa seeds. CP degradation was monitored by HPLC-DAD, and kinetic parameters were calculated for all processes evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2018.11.003DOI Listing
March 2019
2 Reads

Structural insights of stereospecific inhibition of human acetylcholinesterase by VX and subsequent reactivation by HI-6.

Chem Res Toxicol 2018 Nov 21. Epub 2018 Nov 21.

Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) were observed to be stereospecific. The therapeutic reversal of hAChE inhibition by reactivators has also been shown to depend on the stereochemistry of the inhibitor. To gain clarity on the mechanism of stereospecific inhibition, the X-ray crystallographic structures hAChE inhibited by a racemic mixture of VX (P) and its enantiomers were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrestox.8b00294DOI Listing
November 2018
9 Reads

Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.

Chemistry 2018 Nov 20. Epub 2018 Nov 20.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, 92093-0650, USA.

Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. However, tabun remains among the most dangerous nerve agents due to the low reactivation efficacy of standard pyridinium aldoxime antidotes. Therefore, finding an optimal reactivator for prophylaxis against tabun toxicity and for post-exposure treatment is a continued challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201805051DOI Listing
November 2018
13 Reads

Toxic effects and possible mechanisms following malathion exposure in porcine granulosa cells.

Environ Toxicol Pharmacol 2018 Dec 6;64:172-180. Epub 2018 Nov 6.

College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao, 266109, China. Electronic address:

Malathion is a wide spectrum organophosphorothionate insecticide that is frequently found in drinking water, food and foodstuffs. Ovarian granulosa cells modulate oogenesis by providing metabolic nutrients to oocytes. They can decide the fate of folliculogenesis and oocyte maturation by supplying regulatory cues that help in reproduction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13826689183055
Publisher Site
http://dx.doi.org/10.1016/j.etap.2018.11.002DOI Listing
December 2018
10 Reads

Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled.

Anal Bioanal Chem 2019 Jan 16;411(3):617-627. Epub 2018 Nov 16.

Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Permoserstraße 15, 04318, Leipzig, Germany.

The zebrafish embryo is an important model in ecotoxicology but the spatial distribution of chemicals and the relation to observed effects is not well understood. Quantitative imaging can help to gain insights into the distribution of chemicals in the zebrafish embryo. Laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) is used to quantify the uptake and the uptake kinetics of the bromine (Br) containing organophosphate naled (Dibrom®, dimethyl-1,2-dibromo-2,2-dichloroethylphosphate) and its distribution in zebrafish embryos using Br as the marker element. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00216-018-1471-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338705PMC
January 2019
8 Reads

Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats.

Environ Toxicol Pharmacol 2018 Dec 2;64:155-163. Epub 2018 Nov 2.

Institute of Animal Biology, Lviv 79034, Ukraine.

Exposure to the organophosphorus insecticide chlorpyrifos (CPF) can lead to oxidative stress. The aim of this work was to investigate and compare the protective effects of amino acids (l-glutamic acid (l-Glu) and l-cysteine (L-Cys) alone or in combination) for the purpose of suppression and mitigation of CPF-induced oxidative stress in rats. Rats were divided into five groups: CPF, CPF/L-Glu, CPF/L-Glu and l-Cys, CPF/L-Cys, control. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13826689183054
Publisher Site
http://dx.doi.org/10.1016/j.etap.2018.10.010DOI Listing
December 2018
10 Reads

Effective attenuation of glyphosate-induced oxidative stress and granulosa cell apoptosis by vitamins C and E in caprines.

Mol Reprod Dev 2019 Jan 26;86(1):42-52. Epub 2018 Nov 26.

Department of Zoology, Reproductive Physiology Laboratory, Kurukshetra University, Kurukshetra, Haryana, India.

Pesticides are known to cause a wide range of reproductive problems that possess degenerative effects on mammalian fertility. Glyphosate (GLP), a broad-spectrum organophosphate herbicide, is known to be a potent mammalian toxicant. The present study aims at assessing the GLP-induced (0. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/mrd.23084
Publisher Site
http://dx.doi.org/10.1002/mrd.23084DOI Listing
January 2019
9 Reads

Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public.

Environ Sci Pollut Res Int 2019 Jan 8;26(1):91-100. Epub 2018 Nov 8.

Department of Ecology and Environmental Sciences, Pondicherry University, Puducherry, 605014, India.

The need to maximize agricultural productivity has made pesticides an indispensable part of current times. Farmers are unaware of the lurking consequences of the pesticide exposure, which endanger their health. It also puts the unsuspecting consumers in peril. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-018-3642-2DOI Listing
January 2019

Lavandula stoechas essential oils protect against Malathion-induces reproductive disruptions in male mice.

Lipids Health Dis 2018 Nov 8;17(1):253. Epub 2018 Nov 8.

Laboratory Functional Physiology and Bio-resources Valorisation, Higher Institute of Biotechnology of Beja, University of Jendouba, Avenue Habib Bourguiba, BP, 382, 9000, Beja, Tunisia.

Background: The current study was conducted to evaluate the protective effect of Lavandula stoechas essential oils (LSEO) against malathion (M) exposure-caused reprotoxicity in male mice as well as the possible mechanisms implicated in such protection.

Methods: Six-eight-week-old male mice weighting 25-30 g were used and divided into four groups: normal-control, LSEO (50 mg/kg, b.w. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12944-018-0891-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225712PMC
November 2018
3 Reads
2.220 Impact Factor

Insecticide Resistance and Fitness: The Case of Four Populations from Different Brazilian Regions.

Biomed Res Int 2018 9;2018:6257860. Epub 2018 Oct 9.

Laboratório de Mosquitos Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Brazil.

Background: Chemical control is still a major strategy to constrain vector density and mitigate pathogen transmission. However, insecticide overuse poses a high selective pressure, favouring the spread of resistance alleles in natural populations. In an insecticide-free environment, a fitness cost is expected in resistant insects when compared to susceptible counterparts. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/bmri/2018/6257860/
Publisher Site
http://dx.doi.org/10.1155/2018/6257860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198578PMC
February 2019
7 Reads

Differential proteome analysis of rat plasma after diisopropyl fluorophosphate (DFP) intoxication, a surrogate of nerve agent sarin.

Chem Biol Interact 2019 Jan 30;298:66-71. Epub 2018 Oct 30.

Defence Research & Development Establishment (DRDE), Jhansi Road, Gwalior, MP, 474002, India. Electronic address:

Diisopropyl fluorophosphate (DFP), a surrogate of nerve agent sarin, is an organophosphorus (OP) compound which inhibits neuronal enzyme acetylcholinesterase (AChE). Exposure of this compound leads to a wide range of toxic symptoms and survivors may exhibit long term neurotoxicity related to cognitive and memory defects. Due to ease of availability and similar mechanism of action to other highly toxic nerve agent, DFP is widely used as model compound to trace changes associated with nerve agent exposures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2018.10.026DOI Listing
January 2019
12 Reads

Methylenecyclopropyl glycine, not pesticide exposure as the primary etiological factor underlying hypoglycemic encephalopathy in Muzaffarpur, India.

Toxicol Lett 2019 Feb 30;301:34-41. Epub 2018 Oct 30.

Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR - Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, India. Electronic address:

Some districts of Bihar, especially Muzzaffarpur district, have been known to be affected by annual outbreak, called locally as Acute Encephalitis Syndrome (AES) which became one of the major health concerns in Bihar, due to its high fatality and complications. Several hypotheses like bat virus, heat stroke, pesticide exposure and the presence of a compound - methylenecyclopropyl glycine (MCPG) in Litchi have been proposed by different investigators for AES. When the investigators examined the symptoms, signs and the epidemiological data, bat virus and heat stroke hypothesis were ruled out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.10.033DOI Listing
February 2019
3 Reads

Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress.

Toxicol In Vitro 2019 Feb 30;54:338-344. Epub 2018 Oct 30.

Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; Henan Key Laboratory of Fruit and Cucurbit Biology, Zhengzhou 450009, China. Electronic address:

Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2018.10.016DOI Listing
February 2019
4 Reads

Chlorpyrifos Induction of Testicular-Cell Apoptosis through Generation of Reactive Oxygen Species and Phosphorylation of AMPK.

J Agric Food Chem 2018 Nov 15;66(47):12455-12470. Epub 2018 Nov 15.

College of Animal Science and Technology , Northwest A&F University , Yangling , Shaanxi 712100 , China.

Chlorpyrifos (CPF) is the most frequently applied insecticide. Aside from effects on the neuronal cholinergic system, previous studies suggested a potential relationship between CPF exposure and male infertility; however, the molecular mechanism remains elusive. The aim of this study was to investigate the toxic effect of CPF on testicular cells and the potential mechanism via in vitro and in vivo experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.8b03407DOI Listing
November 2018
6 Reads

Characterization of brominated, chlorinated, and phosphate flame retardants in San Francisco Bay, an urban estuary.

Sci Total Environ 2019 Feb 11;652:212-223. Epub 2018 Oct 11.

Cooperative Wildlife Research Laboratory and Department of Zoology, Southern Illinois University, Carbondale, IL 62901, USA.

Flame retardant chemical additives are incorporated into consumer goods to meet flammability standards, and many have been detected in environmental matrices. A uniquely wide-ranging characterization of flame retardants was conducted, including polybrominated diphenyl ethers (PBDEs) and 52 additional brominated, chlorinated, or phosphate analytes, in water, sediment, bivalves, and harbor seal blubber of San Francisco Bay, a highly urbanized estuary once considered a hot spot for PBDE contamination. Among brominated flame retardants, PBDEs remained the dominant contaminants in all matrices, though declines have been observed over the last decade following their phase-out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.10.096DOI Listing
February 2019

In vitro exposure to CPF affects bovine sperm epigenetic gene methylation pattern and the ability of sperm to support fertilization and embryo development.

Environ Mol Mutagen 2019 01 26;60(1):85-95. Epub 2018 Oct 26.

Dipartimento di Biologia, Università di Napoli Federico II, Naples, Italy.

Several studies have demonstrated that overexposure to pesticides can reduce mammalian sperm quality, impairing male fertility. Chlorpyrifos (CPF), a widely used organophosphate pesticide, was shown to impair spermatogenesis by inducing the formation of highly reactive toxic intermediates. To gain further insight into the mechanisms underlying the cytotoxicity and genotoxicity of CPF, bovine spermatozoa were exposed in vitro to environmental CPF concentrations and the motility, in vitro fertilization rates, DNA fragmentation, chromatin alterations, and methylation patterns were assessed. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/em.22242
Publisher Site
http://dx.doi.org/10.1002/em.22242DOI Listing
January 2019
12 Reads

Paraoxonase-1 genetic polymorphisms in organophosphate metabolism.

Toxicology 2019 Jan 22;411:24-31. Epub 2018 Oct 22.

Laboratory of Toxicology, School of Medicine, University of Crete, 71003, Heraklion, Greece.

Organophosphates (OPs) are a class of chemicals commonly used in agriculture as pesticides, that can often lead to severe toxicity in humans. Paraoxonase-1 (PON1) belongs to a family of A-esterases and hydrolyses several OPs while also serving other biological roles. Two main genetic polymorphisms have been shown to affect enzymatic ability; an A > G transition in the 192nd position (192 Q/R, rs662), and an A > T at codon 55 (55 M/L, rs854560). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0300483X183048
Publisher Site
http://dx.doi.org/10.1016/j.tox.2018.10.012DOI Listing
January 2019
12 Reads

Prevention of pesticide-induced neuronal dysfunction and mortality with nucleophilic poly-Oxime topical gel.

Sci Adv 2018 Oct 17;4(10):eaau1780. Epub 2018 Oct 17.

Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK Campus, Bellary Road, Bangalore, 560065 Karnataka, India.

Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunction, loss of endurance, and death in severe cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aau1780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192682PMC
October 2018
8 Reads

Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells.

Yonsei Med J 2018 Nov;59(9):1096-1106

Department of Rehabilitation Medicine, Huaihe Hospital of Henan University, Kaifeng, China.

Purpose: Alzheimer's disease (AD) is the sixth most common cause of death in the United States. MicroRNAs have been identified as vital players in neurodegenerative diseases, including AD. microRNA-128 (miR-128) has been shown to be dysregulated in AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3349/ymj.2018.59.9.1096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192880PMC
November 2018
3 Reads

Lethality of synthetic and natural acaricides to worker honey bees (Apis mellifera) and their impact on the expression of health and detoxification-related genes.

Environ Sci Pollut Res Int 2018 Dec 15;25(34):34730-34739. Epub 2018 Oct 15.

School of Environmental Sciences, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

In this study, honey bees (Apis mellifera L.) were exposed to LD and LD doses of five commonly used acaricides for controlling the parasitic mite, Varroa destructor. LD values at 48 h post-treatment showed that tau-fluvalinate was the most toxic, followed by amitraz, coumaphos, thymol, and formic acid. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11356-018-3205-6
Publisher Site
http://dx.doi.org/10.1007/s11356-018-3205-6DOI Listing
December 2018
5 Reads

Effects of a glyphosate-based herbicide on survival and oxidative status of a non-target herbivore, the Colorado potato beetle (Leptinotarsa decemlineata).

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 11;215:47-55. Epub 2018 Oct 11.

Department of Biological and Environmental Science, University of Jyväskylä, FI-40014 Jyväskylä, Finland. Electronic address:

Glyphosate is the globally most used herbicide against a wide range of weeds. Glyphosate has been considered safe to animals as it mainly targets physiological pathways in plants. However, recent toxicological studies have revealed that glyphosate can cause various toxic effects also on animals. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15320456183013
Publisher Site
http://dx.doi.org/10.1016/j.cbpc.2018.09.005DOI Listing
January 2019
12 Reads

Uptake and toxic effects of triphenyl phosphate on freshwater microalgae Chlorella vulgaris and Scenedesmus obliquus: Insights from untargeted metabolomics.

Sci Total Environ 2019 Feb 5;650(Pt 1):1239-1249. Epub 2018 Sep 5.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore; NUS Environmental Research Institute (NERI), #02-01, T-Lab Building (TL), 5A Engineering Drive 1, Singapore 117411, Singapore. Electronic address:

The flame retardant triphenyl phosphate (TPhP) has been widely detected in surface waters. Yet, little information is known regarding its impact on microalgae. We investigated the uptake and toxicity of TPhP on two freshwater microalgae Chlorella vulgaris (CV) and Scenedesmus obliquus (SO) after exposure to 10 μg/l-10 mg/l for 5 days. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697183344
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2018.09.024DOI Listing
February 2019
21 Reads

Effects of coumaphos and imidacloprid on honey bee (Hymenoptera: Apidae) lifespan and antioxidant gene regulations in laboratory experiments.

Sci Rep 2018 Oct 9;8(1):15003. Epub 2018 Oct 9.

USDA, ARS, Thad Cochran Southern Horticultural Research Laboratory, Poplarville, MS, USA.

The main objective of this study was to test comparatively the effects of two common insecticides on honey bee Apis mellifera worker's lifespan, food consumption, mortality, and expression of antioxidant genes. Newly emerged worker bees were exposed to organophosphate insecticide coumaphos, a neonicotinoid imidacloprid, and their mixtures. Toxicity tests were conducted along with bee midgut immunohistological TUNEL analyses. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-018-33348-4
Publisher Site
http://dx.doi.org/10.1038/s41598-018-33348-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177410PMC
October 2018
2 Reads

Characterization of acute intrastriatal effects of paraoxon on in vivo dopaminergic neurotransmission using microdialysis in freely moving rats.

Toxicol Lett 2018 Dec 4;299:124-128. Epub 2018 Oct 4.

Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, Campus Lagoas Marcosende, 36310 Vigo, Spain.

Paraoxon (POX) is an extremely neurotoxic organophosphorous compound (OP) which main toxic mechanism is the irreversible inhibition of cholinesterase. Although the cholinergic system has always been linked as responsible for its acute effects, experimental studies have suggested that the dopaminergic system also may be a potential target for OPs. Based on this, in this study, the acute intrastriatal effects of POX on dopaminergic neurotransmission were characterized in vivo using brain microdialysis in freely moving rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.09.017DOI Listing
December 2018
9 Reads

The organophosphate pesticide methamidophos opens the blood-testis barrier and covalently binds to ZO-2 in mice.

Toxicol Appl Pharmacol 2018 Dec 3;360:257-272. Epub 2018 Oct 3.

Department of Physiology, Biophysics and Neuroscience, Cinvestav, Mexico City 07360, Mexico. Electronic address:

Methamidophos (MET) is an organophosphate (OP) pesticide widely used in agriculture in developing countries. MET causes adverse effects in male reproductive function in humans and experimental animals, but the underlying mechanisms remain largely unknown. We explored the effect of MET on mice testes (5 mg/kg/day/4 days), finding that this pesticide opens the blood-testis barrier and perturbs spermatogenesis, generating the appearance of immature germ cells in the epididymis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0041008X183046
Publisher Site
http://dx.doi.org/10.1016/j.taap.2018.10.003DOI Listing
December 2018
3 Reads
3.705 Impact Factor

Biological impacts of organophosphates chlorpyrifos and diazinon on development, mitochondrial bioenergetics, and locomotor activity in zebrafish (Danio rerio).

Neurotoxicol Teratol 2018 Nov - Dec;70:18-27. Epub 2018 Oct 2.

Department of Physiological Sciences, Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address:

The objectives of this study were to compare the biological responses in developing zebrafish to two organophosphate insecticides, chlorpyrifos (CPF) and diazinon (DZN). Zebrafish embryos were exposed to either solvent control (0.1% DMSO, v/v), or one dose of 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08920362183011
Publisher Site
http://dx.doi.org/10.1016/j.ntt.2018.10.001DOI Listing
October 2018
4 Reads

Mass spectrometric identification of in vitro-generated metabolites of two emerging organophosphate flame retardants: V6 and BDP.

Chemosphere 2018 Dec 3;212:1047-1057. Epub 2018 Sep 3.

Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium. Electronic address:

The aim of the present study was to investigate the in vitro metabolism of two emerging organophosphate flame retardants, namely tetrekis(2-chlorethyl)dichloroisopentyldiphosphate (V6) and bisphenol-A bis-diphenyl phosphate (BDP) in human liver microsomes (HLMs), HLM S9 fractions and in human serum. In particular, the role of cytochrome P450 (CYPs) enzymes and/or paraoxonases (PONs) in the formation of V6 and BDP phase I metabolites was studied. Mono-, di-hydroxylated and hydrolytic phase I metabolites of V6 were mainly formed by CYPs in HLMs, while hydrolytic and O-dealkylated phase I metabolites of BDP were generated by PONs mainly in serum experiments. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535183161
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2018.08.142DOI Listing
December 2018
4 Reads

Chemical and biological transfer: Which one is responsible for the maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish?

Environ Pollut 2018 Dec 26;243(Pt B):1376-1382. Epub 2018 Sep 26.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China; Collaborative Innovation Centre for Efficient and Health Production of Fisheries in Hunan Province, Changde, 415000, China. Electronic address:

Maternal transfer toxicity of chemicals has mainly focused in fish on the chemical transfer from maternal generation to offspring, and limited information is available for the evaluation of effects of chemicals from a biological transfer perspective. In this study, first-generation (F0) zebrafish larvae (D. rerio) were exposed to 0, 50, 500 or 5000 ng/L TDCIPP from 14 days post fertilization (dpf) to 120 dpf. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02697491183108
Publisher Site
http://dx.doi.org/10.1016/j.envpol.2018.09.114DOI Listing
December 2018
13 Reads