9,061 results match your criteria Toxicity Organophosphate


Joint probabilistic analysis of risk for aquatic species and exceedence frequency for the agricultural use of chlorpyrifos in the Pampean region, Argentina.

Environ Toxicol Chem 2019 Apr 15. Epub 2019 Apr 15.

Centro de Investigaciones en Toxicología Ambiental y Agrobiotecnología del Comahue (CITAAC), Universidad Nacional del Comahue y CONICET. Buenos Aires 1400, Neuquén, Neuquén, Argentina.

The Pampa Húmeda region in Argentina is characterized by soybean, wheat, and maize production, with intensive application of agrochemicals such as herbicides and insecticides. We used a joint probabilistic approach to analyze the probabilities for environmental chlorpyrifos concentrations measured in the Pampa Húmeda to exceed acute or chronic Hazard Concentration-5 (HC5) values estimated from Species Sensitivity Distributions (SSD) for aquatic species. Chlorpyrifos concentrations in water ranged from 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/etc.4441DOI Listing

Comparative analyses of the neurobehavioral, molecular, and enzymatic effects of organophosphates on embryo-larval zebrafish (Danio rerio).

Neurotoxicol Teratol 2019 Apr 9;73:67-75. Epub 2019 Apr 9.

Department of Environmental Toxicology, Texas Tech University, Lubbock, TX, 79416, USA.

Organophosphates insecticides (OPs) are common surface water contaminants in both urban and agricultural landscapes. Neurobehavioral effects on larval fish are known to occur at concentrations higher than those reported in the environment. The aim of this study was to perform a comparative analysis of neurobehavioral, molecular, and biochemical responses of four OPs (diazinon, dichlorvos, malathion, methyl-parathion) via the following endpoint measurements: distance traveled, velocity, gene expression (AChE, c-Fos, LINGO-1B, GRIN-1B), enzymatic acetylcholinesterase (AChE) activity, and carboxylesterase (CES) activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ntt.2019.04.002DOI Listing
April 2019
2 Reads

Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to organophosphate esters (OPEs).

Toxicol Appl Pharmacol 2019 Apr 8;371:84-94. Epub 2019 Apr 8.

Department of Biology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. Electronic address:

Organophosphate esters (OPEs) are frequently used as replacements for the banned polybrominated diphenyl ether (PBDEs). Since OPEs are structurally similar to organophosphate pesticides, exposure and toxicity of these compounds is of significant societal and scientific interest. Cytotoxicity (MTT), biotransformation (cyp1a1) and oxidative stress responses (gpx1, gr, gsta2, cat) were investigated in H4IIE cells exposed for 48 h to four different OPEs (tributyl phosphate (TBP), tris(2-butoxyethyl) phosphate (TBOEP), tris-(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPP)). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2019.04.004DOI Listing
April 2019
1 Read

Organ toxicity attenuation by nanomicelles containing curcuminoids: Comparing the protective effects on tissues oxidative damage induced by diazinon.

Iran J Basic Med Sci 2019 Jan;22(1):17-24

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Objectives: Diazinon (DZ) is an organophosphate pesticide that induces oxidative damage in different organs. The aim of this study was to compare the effectiveness of nanomicelles containing curcuminoids (NCUR) and natural curcumin (CUR) in attenuating the oxidative damage induced by DZ in male rats.

Materials And Methods: After a single intraperitoneal (IP) injection of DZ (100 mg/kg), the rats were administered either CUR or NCUR (25 and 60 mg/kg, IP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22038/ijbms.2018.23229.5874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437454PMC
January 2019
1 Read
0.604 Impact Factor

Comparative analysis of freshwater species sensitivity distributions and ecotoxicity for priority pesticides: Implications for water quality criteria.

Ecotoxicol Environ Saf 2019 Jul 27;176:119-124. Epub 2019 Mar 27.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

Organochlorine pesticides (OCPs) and organophosphate pesticides (OPPs) posed severe threats to the aquatic environment in China. The toxicity data of 18 priority OCPs and OPPs for Chinese and American species were collected, and their species sensitivity distributions (SSDs) and ecotoxicity were compared. Physicochemical characteristics and chemical structures were used to analyze the difference in the pesticide toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.03.087DOI Listing
July 2019
1 Read

Screening for improved nerve agent simulants and insights into organophosphate hydrolysis reactions from DFT and QSAR modeling.

Chemistry 2019 Mar 28. Epub 2019 Mar 28.

Northwestern University, Chemical and Biological Engineering, 2145 Sheridan Road, IL 60208-3120, Evanston, UNITED STATES.

The effective detoxification of chemical warfare agents, specifically nerve agents, is a pressing issue in the modern world. Due to the high toxicity of these molecules, simulants are often used in experiments as substitutes for the agents. However, there is little reason to believe that the current simulants used in the literature are optimal predictors of nerve agent reactivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201900655DOI Listing
March 2019
1 Read

Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.

Neurobiol Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA; MIND Institute, School of Medicine, University of California-Davis, 2825 50th Street, Sacramento, CA 95817, USA. Electronic address:

Current medical countermeasures for organophosphate (OP)-induced status epilepticus (SE) are not effective in preventing long-term morbidity and there is an urgent need for improved therapies. Rat models of acute intoxication with the OP, diisopropylfluorophosphate (DFP), are increasingly being used to evaluate therapeutic candidates for efficacy in mitigating the long-term neurologic effects associated with OP-induced SE. Many of these therapeutic candidates target neuroinflammation and oxidative stress because of their implication in the pathogenesis of persistent neurologic deficits associated with OP-induced SE. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09699961193007
Publisher Site
http://dx.doi.org/10.1016/j.nbd.2019.03.019DOI Listing
March 2019
3 Reads

Pollution status and bioremediation of chlorpyrifos in environmental matrices by the application of bacterial communities: A review.

J Environ Manage 2019 Jun 18;239:124-136. Epub 2019 Mar 18.

Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Laboratorio de Biotecnología. Av. Universidad S/N Ciudad Universitaria, San Nicolás de Los Garza, Nuevo León, CP66451, Mexico.

Pesticides currently play a significant role in enhancing agricultural production and offer economic assistance to our farmers. However, their indiscriminate and injudicious application has caused environmental problems and public health concerns. Chlorpyrifos, a pesticide of organophosphate category is used globally as an insecticide, acaricide, and termiticide in households, public health, and agriculture against pests of a wide range. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.03.048DOI Listing
June 2019
1 Read

Effects of prenatal exposure to temephos on behavior and social interaction.

Neuropsychiatr Dis Treat 2019 11;15:669-673. Epub 2019 Mar 11.

Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil,

The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against in Brazil's public health programs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/NDT.S193896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417020PMC
March 2019
1 Read

Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis.

Neurobiol Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurology, Virginia Commonwealth University, Richmond, VA 23298, USA; Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:

Organophosphate (OP) chemicals include pesticides such as parathion, and nerve gases such as sarin and soman and are considered major chemical threat agents. Acute OP exposure is associated with a cholinergic crisis and status epilepticus (SE). It is also known that the survivors of OP toxicity exhibit neurobehavioral deficits such as mood changes, depression, and memory impairment, and acquired epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.03.006DOI Listing
March 2019
8 Reads

Removal of chlorpyrifos, an insecticide using metal free heterogeneous graphitic carbon nitride (g-CN) incorporated chitosan as catalyst: Photocatalytic and adsorption studies.

Int J Biol Macromol 2019 Mar 11;132:289-299. Epub 2019 Mar 11.

Department of Chemistry, The Gandhigram Rural Institute, Deemed to be University, Gandhigram, 624 302 Dindigul, Tamil Nadu, India. Electronic address:

The present study investigates the photocatalytic degradation of an organic pesticide using a metal free heterogeneous graphitic carbon nitride (g-CN) incorporated into chitosan as catalyst. Chlorpyrifos (O, O-diethylO-3,5,6-trichloro-2-pyridyl phosphorothioate (CPFS)), an insecticide includes in a class of Organophosphate pesticides with a chemical formula (CHClNOPS). It is widely used in agricultural lands to control pests in cotton, fruit and vegetables. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.03.071DOI Listing
March 2019
1 Read

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication.

Neurotoxicology 2019 Mar 7;73:81-84. Epub 2019 Mar 7.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA. Electronic address:

Acute intoxication with organophosphate cholinesterase inhibitors (OPs) is a significant human health threat, and current medical countermeasures for OP poisoning are of limited therapeutic efficacy. The rat model of acute intoxication with diisopropylfluorophosphate (DFP) is increasingly being used to test candidate compounds for efficacy in protecting against the immediate and long-term consequences of acute OP toxicity. In this model, rats are typically pretreated with pyridostigmine bromide (PB), a reversible cholinesterase inhibitor, to enhance survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2019.03.001DOI Listing
March 2019
1 Read

Toxicity and neurophysiological impacts of plant essential oil components on bed bugs (Cimicidae: Hemiptera).

Sci Rep 2019 Mar 8;9(1):3961. Epub 2019 Mar 8.

Center for Urban and Industrial Pest Management, Department of Entomology, Purdue University, West Lafayette, IN, 47907, USA.

Bed bugs (Cimex lectularius L.) are globally important human parasites. Integrated pest management (IPM) approaches, which include the use of essential oil-based insecticidal compounds, have been proposed for their control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-40275-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408565PMC
March 2019
2 Reads

Flame retardant concentrations and profiles in wild birds associated with landfill: A critical review.

Environ Pollut 2019 Feb 23;248:646-658. Epub 2019 Feb 23.

School of Geography, Earth and Environmental Sciences, College of Life & Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. Electronic address:

Given factors such as their persistence and toxicity, legacy brominated flame retardants (BFRs) like polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), are designated as persistent organic pollutants (POPs) and are subject to regulation. Waste streams likely represent a substantial reservoir of legacy BFRs given that they were once widely applied to goods which are increasingly likely to be obsolete. Waste streams are also increasingly likely to be a source of emerging flame retardants, in particular, novel BFRs (NBFRs), the halogenated norbornene flame retardant Dechlorane Plus (DDC-CO) and the brominated, chlorinated or non-halogenated organophosphate triester flame retardants (PFRs). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02697491183546
Publisher Site
http://dx.doi.org/10.1016/j.envpol.2019.01.103DOI Listing
February 2019
5 Reads

Insecticide Toxicity to Drosophila suzukii (Diptera: Drosophilidae) parasitoids: Trichopria anastrephae (Hymenoptera: Diapriidae) and Pachycrepoideus vindemmiae (Hymenoptera: Pteromalidae).

J Econ Entomol 2019 Mar 4. Epub 2019 Mar 4.

Crop Protection Department, Federal University of Pelotas (UFPel) Agronomy School "Eliseu Maciel," PO Box 354, 96010-900, Capão do Leão - RS - Brazil.

Drosophila suzukii (Matsumura) is an important pest of small fruits, which has been causing significant damage to commercial crops in North America, Europe, and South America. This pest is mainly controlled with insecticide applications because of its highly biotic potential and polyphagy. However, studies conducted in crops infested by D. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jee/advance-article/doi/10.1093/jee
Publisher Site
http://dx.doi.org/10.1093/jee/toz033DOI Listing
March 2019
6 Reads

A retrospective study of poisoning deaths from forensic autopsy cases in northeast China (Liaoning).

J Forensic Leg Med 2019 Apr 21;63:7-10. Epub 2019 Feb 21.

School of Forensic Medicine, China Medical University, Shenyang 110122, China. Electronic address:

Acute poisoning is a public health threat that leads to morbidity and mortality worldwide. In this retrospective study, we evaluated autopsies from deaths caused by acute poisoning from 2008 to 2017 at the School of Forensic Medicine, China Medical University (SFMCMU) in the Liaoning Province, northeast China. A total of 140 poisoning deaths were investigated and the demographic characteristics, causes and manner of death, toxics category were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jflm.2019.02.008DOI Listing
April 2019
3 Reads
0.989 Impact Factor

Limitations of pesticide genotoxicity testing using the bacterial in vitro method.

Toxicol In Vitro 2019 Jun 23;57:110-116. Epub 2019 Feb 23.

The Federal Budgetary Establishment of Science, «Federal Scientific Center of Hygiene named after F.F. Erisman» of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Semashko Str. 2., Mytishchi 141014, Russian Federation.

The results of genotoxicity assessment of 115 technical grade pesticide products (61 names) with the Ames test and mammalian erythrocyte micronucleus test in vivo are presented. In most cases, unidirectional results were found. However, some pesticides belonging to classes of neonicotinoids, derivatives of phenylurea, glycine and phenoxycarboxylic acids showed genotoxic effects only under in vivo conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2019.02.018DOI Listing
June 2019
1 Read

Brain acetylcholinesterase of three perciformes: From the characterization to the in vitro effect of metal ions and pesticides.

Ecotoxicol Environ Saf 2019 May 22;173:494-503. Epub 2019 Feb 22.

Universidade Federal Rural de Pernambuco (UFRPE), Departamento de Pesca e Aquicultura, Recife, Brazil.

Estuarine environments gather pollution from large regions including urban and industrial zones. The monitoring of environmental quality in these areas constitutes a real requirement for global sustainable development. Therefore, the aim of this study was to characterize the physicochemical and kinetic parameters of brain acetylcholinesterase (AChE) in the species Centropomus undecimalis, Diapterus auratus and Diapterus rhombeus and to assess the effects (in vitro) of pesticides and metal ions on their respective activities in order to investigate them as potential biomarkers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.02.047DOI Listing

Cholinesterases characterization of three tropical fish species, and their sensitivity towards specific contaminants.

Ecotoxicol Environ Saf 2019 May 22;173:482-493. Epub 2019 Feb 22.

Departamento de Biologia, Universidade de Aveiro, Centro de Estudos do Ambiente e do Mar (CESAM), Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address:

Cholinesterases are frequent targets for toxic effects, namely by insecticides derived from phosphoric and carbamic acids. This effects allows the use of cholinesterase inhibition as a biomarker for contamination of aquatic environments by these specific chemical agents. However, cholinesterases are differently responsive to environmental contaminants, according to their different forms and locations. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01476513193013
Publisher Site
http://dx.doi.org/10.1016/j.ecoenv.2019.01.105DOI Listing
May 2019
5 Reads

Molecular characterization of monocrotophos and chlorpyrifos tolerant bacterial strain for enhancing seed germination of vegetable crops.

Chemosphere 2019 May 14;223:636-650. Epub 2019 Feb 14.

Department of Soil Science and Agricultural Chemistry, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, 221005, UP, India.

The main aim of this study is to investigate the toxicity of organophosphate (OPs) insecticides monocrotophos (MCP) and chlorpyrifos (CLS) on plant growth promoting (PGP) properties and seed germination of brinjal, tomato and okra vegetables inoculated by Microbacterium hydrocarbonoxydans (BHUJP-P1), Stenotrophomonas rhizophila (BHUJP-P2), Bacillus licheniformis (BHUJP-P3) and Bacillus cereus (BHUJP-P4). Maximum increase in microbial growth (52.6% & 47. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.053DOI Listing
May 2019
3 Reads

Current and future daily temperature fluctuations make a pesticide more toxic: Contrasting effects on life history and physiology.

Environ Pollut 2019 Feb 11;248:209-218. Epub 2019 Feb 11.

Evolutionary Stress Ecology and Ecotoxicology, University of Leuven, Charles Deberiotstraat 32, B-3000, Leuven, Belgium.

There is increasing concern that climate change may make organisms more sensitive to chemical pollution. Many pesticides are indeed more toxic at higher mean temperatures. Yet, we know next to nothing about the effect of another key component of climate change, the increase of daily temperature fluctuations (DTFs), on pesticide toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.02.022DOI Listing
February 2019
3 Reads

Insecticide Resistance in Drosophila melanogaster (Diptera: Drosophilidae) is Associated with Field Control Failure of Sour Rot Disease in a New York Vineyard.

J Econ Entomol 2019 Feb 23. Epub 2019 Feb 23.

Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY.

Sour rot is a complex disease of grapes caused by an interaction of yeast, acetic acid bacteria, and Drosophila spp. Application of insecticides (most commonly zeta-cypermethrin) targeting Drosophila has previously provided substantial control of sour rot in wine grapes of New York vineyards. In harvest season of 2018, a control failure of sour rot and high populations of Drosophila, mostly Drosophila melanogaster, were observed in a vineyard in the Finger Lakes region, NY, despite repeated applications of zeta-cypermethrin (Mustang Maxx). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jee/toz039DOI Listing
February 2019
1 Read

Evaluation of toxicity of clothianidin (neonicotinoid) and chlorfenapyr (pyrrole) insecticides and cross-resistance to other public health insecticides in Anopheles arabiensis from Ethiopia.

Malar J 2019 Feb 22;18(1):49. Epub 2019 Feb 22.

Entomology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329-4027, USA.

Background: Insecticide-based interventions play an integral role in malaria vector control. However, the continued spread of insecticide resistance threatens to undermine progress made thus far and may ultimately lead to operational failure of current control measures. Clothianidin and chlorfenapyr both have unique modes of action and have expanded the number of insecticide classes available to vector control programmes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12936-019-2685-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387473PMC
February 2019
1 Read

Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.

J Vet Med Sci 2019 Feb 15. Epub 2019 Feb 15.

The Institute of Environmental Toxicology.

The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC+PARA exposure compared to that of the control, MXC, and PARA groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1292/jvms.18-0641DOI Listing
February 2019
1 Read

H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line.

Sci Total Environ 2019 May 4;665:162-170. Epub 2019 Feb 4.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China. Electronic address:

Organophosphate flame retardants (OPFRs) are frequently found in the environment and could be adversely affecting organisms. In fact, nine OPFRs have been shown to cause endocrine disruptions, but information on the metabolism-perturbing properties of these OPFRs remains unclear. In this study, the H-nuclear magnetic resonance (NMR) based metabolomic method was applied to evaluate the metabolic disturbances caused by these nine OPFRs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.02.055DOI Listing
May 2019
1 Read

Effect of microplastics on the toxicity of chlorpyrifos to the microalgae Isochrysis galbana, clone t-ISO.

Ecotoxicol Environ Saf 2019 May 12;173:103-109. Epub 2019 Feb 12.

Spanish Institute of Oceanography, IEO, Oceanographic Center of Murcia, Varadero 1, E-30740 San Pedro del Pinatar, Murcia, Spain. Electronic address:

It is highly likely that phytoplanktonic organisms will interact with MPs in the ocean, and consequently with the pollutants sorbed onto their surfaces. Microalgae play an essential role in maintaining the balance of the marine ecosystem due to the fact that they are a primary producer and the base of marine trophic chains. Therefore, their fitness represents an important index in the assessment of water quality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.02.020DOI Listing
May 2019
2 Reads

Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera.

Pestic Biochem Physiol 2019 Feb 21;154:46-59. Epub 2018 Dec 21.

Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China. Electronic address:

When any living organism is frequently exposed to any drugs or toxic substances, they evolve different detoxification mechanism to confront with toxicants during absorption and metabolism. Likewise, the insects have evolved detoxification mechanisms as they are frequently exposed to different toxic secondary plant metabolites and commercial insecticides. ABC transporter superfamily is one of the largest and ubiquitous group of proteins which play an important role in phase III of the detoxification process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pestbp.2018.12.007DOI Listing
February 2019
2 Reads
2.014 Impact Factor

Plant allelochemicals affect tolerance of polyphagous lepidopteran pest Helicoverpa armigera (Hübner) against insecticides.

Pestic Biochem Physiol 2019 Feb 18;154:32-38. Epub 2018 Dec 18.

Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, College of Crop Science, Fujian Agriculture and Forestry University, Jinshan, Fuzhou 350002, China. Electronic address:

Cotton bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae), is a polyphagous lepidopteran pest distributed worldwide with a broad spectrum of host plants. However, the mechanism of H. armigera adaptation to various insecticides and defensive allelochemicals in its host plants is not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pestbp.2018.12.009DOI Listing
February 2019
2 Reads

Chlorpyrifos stimulates expression of vitamin D receptor in skin cells irradiated with UVB.

Pestic Biochem Physiol 2019 Feb 12;154:17-22. Epub 2018 Dec 12.

Institute of Rural Health, Department of Molecular Biology and Translational Research, Lublin, Poland; University of Information Technology and Management, Department of Medical Biology and Translational Research, Rzeszow, Poland. Electronic address:

Skin, the organ responsible for vitamin D synthesis, is fully exposed to many xenobiotics, e.g. polycyclic aromatic hydrocarbons and pesticides. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00483575183052
Publisher Site
http://dx.doi.org/10.1016/j.pestbp.2018.12.003DOI Listing
February 2019
4 Reads

Chlorpyrifos-Induced Delayed Neurotoxicity with A Rare Presentation of Flaccid Quadriplegia: A Diagnostic Challenge.

Eur J Case Rep Intern Med 2018 31;5(1):000751. Epub 2018 Jan 31.

Internal Medicine Department A, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Chlorpyrifos is an organophosphate compound recognized as causing acute toxicity. However, organophosphate-induced delayed polyneuropathy (OPIDP), although rare, has also been described. We describe an unusual presentation of OPIDP with flaccid quadriplegia progressing to a locked-in-like syndrome, 30 days after a 60-year-old man voluntarily ingested chlorpyrifos. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2017_000751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346943PMC
January 2018
1 Read

Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats.

Drug Chem Toxicol 2019 Mar 12;42(2):220-230. Epub 2019 Feb 12.

a Department of Biophysics , Panjab University , Chandigarh , India.

Chlorpyrifos (CPF) has been considered as one of the most potent organophosphates and is linked to several neurological disorders. On the other hand, Quercetin is a vital plant flavanoid and has been reported to regulate a number of physiological processes in the central nervous system. The present study was conducted to investigate the protective potential of quercetin during chlorpyrifos induced neurotoxicity. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
Publisher Site
http://dx.doi.org/10.1080/01480545.2019.1569022DOI Listing
March 2019
6 Reads

Silencing of triazophos-induced Hexokinase-1-like reduces fecundity in Nilaparvata lugens (Stål) (Hemiptera: Delphacidae).

Pestic Biochem Physiol 2019 Jan 29;153:176-184. Epub 2018 Nov 29.

School of Horticulture and Plant Protection, Yangzhou University, Yangzhou 225009, PR China; Joint Laboratory Safety of International Cooperation of Agriculture & Agricultural-Products, Yangzhou University, Yangzhou 225009, PR China.

Hexokinase is a rate-limiting enzyme that plays pivotal roles in glucose homeostasis and energy metabolism via glucose (Glc) phosphorylation and Glc signaling mediation. Previous investigations have revealed the modulatory role of Hexokinase (Hex) genes involved in proper glucose regulation during insect diapause and embryo development, whereas whether it functions in insect fecundity remains largely unknown. We aimed to explore the relationship between Triazophos (TZP)-induced Hex-1 and fecundity of female Nilaparvata lugens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pestbp.2018.11.016DOI Listing
January 2019
2 Reads

The organophosphate pesticide -OP- malathion inducing thyroidal disruptions and failures in the metamorphosis of the Senegalese sole, Solea senegalensis.

BMC Vet Res 2019 Feb 11;15(1):57. Epub 2019 Feb 11.

Instituto de Ciencias Marinas de Andalucía-ICMAN, CSIC Campus Universitario Río San Pedro, 11510, Puerto Real, Cádiz, Spain.

Background: Organophosphate pesticides-OP-, like malathion, can alter the normal functioning of neuro-endocrine systems (e.g., hypothalamus-pituitary-thyroid-HPT- axis), and to interfere on the thyroidal homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12917-019-1786-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371575PMC
February 2019
1 Read

Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides.

Acta Naturae 2018 Oct-Dec;10(4):125-128

Institute of Bioorganic Chemistry, Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Miklukho-Maklaya Str., 16/10, Moscow, 117997, Russia.

The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351027PMC
February 2019
1 Read

Immunostimulating effects of Ginkgo biloba extract against toxicity induced by organophosphate pesticide, diazinon in rainbow trout, Oncorhynchus mykiss: innate immunity components and immune-related genes.

Environ Sci Pollut Res Int 2019 Mar 2;26(9):8798-8807. Epub 2019 Feb 2.

Department of Fisheries and Environmental Sciences, Faculty of Natural Resources and Earth Sciences, Shahrekord University, Shahrekord, Iran.

The immunostimulating and therapeutic properties of Ginkgo biloba (GB) have always been the focus of traditional medicine over thousands of years. During last decade, special attentions were paid to use of GB in aquaculture to enhance fish health and survival. In the present study, we investigated for the first time the immunogenic effects of dietary GB against oxidative and toxicity induced by organophosphate pesticide, diazinon. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11356-019-04327-7
Publisher Site
http://dx.doi.org/10.1007/s11356-019-04327-7DOI Listing
March 2019
11 Reads

Detoxification mechanism of organophosphorus pesticide via carboxylestrase pathway that triggers de novo TAG biosynthesis in oleaginous microalgae.

Aquat Toxicol 2019 Apr 24;209:49-55. Epub 2019 Jan 24.

Joint Institute for High Temperatures, 13/2 Izhorskaya St, Moscow, 125412, Russia.

Organophosphorus compounds exhibit a wide range of toxicity to mammals. In this study the effect of malathion on the growth and biochemical parameters of microalgae was evaluated. Three microalgae (Micractinium pusillum UUIND2, Chlorella singulari UUIND5 and Chlorella sorokiniana UUIND6) were used in this study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0166445X183108
Publisher Site
http://dx.doi.org/10.1016/j.aquatox.2019.01.019DOI Listing
April 2019
2 Reads

Genotoxic and immunotoxic effects of the organophosphate metabolite diethyldithiophosphate (DEDTP) in Vivo.

Toxicol Appl Pharmacol 2019 Mar 29;366:96-103. Epub 2019 Jan 29.

Toxicology Department, Centre for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Av. IPN 2508, San Pedro Zacatenco, GA. Madero, Mexico City 07360, Mexico. Electronic address:

Diethyldithiophosphate (DEDTP) is a metabolite produced by the degradation of organophosphorus pesticides and a dialkylphosphate that is chemically synthesized with widespread commercial use. DEDTP is a stable compound, and most studies considered it harmless. However, some studies found adverse effects in vitro, including toxicity in different human cell types. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0041008X193003
Publisher Site
http://dx.doi.org/10.1016/j.taap.2019.01.023DOI Listing
March 2019
16 Reads

Exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) induces vascular toxicity through Nrf2-VEGF pathway in zebrafish and human umbilical vein endothelial cells.

Environ Pollut 2019 Apr 3;247:293-301. Epub 2019 Jan 3.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

The growing production and extensive use of organophosphate flame retardants (OPFRs) have led to an increase in their environmental distribution and human exposure. Developmental toxicity is a major concern of OPFRs' adverse health effects. However, the impact of OPFRs exposure on vascular development and the toxicity pathway for developmental defects are poorly understood. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02697491183502
Publisher Site
http://dx.doi.org/10.1016/j.envpol.2018.12.066DOI Listing
April 2019
11 Reads

Sub-lethal toxicity of chlorpyrifos alone and in combination with polyethylene glycol to common carp (Cyprinus carpio).

Chemosphere 2019 Mar 13;219:981-988. Epub 2018 Dec 13.

Department of Aquaculture, Faculty of Natural Resources and the Environment, Behbahan Khatam Alanbia University of Technology, Khuzestan Province, Iran.

In the present study, sub-lethal effects of chlorpyrifos, alone (25 and 50 μg L) and in combination with Polyethylene glycol (5 and 10 mg L), on common carp were investigated. Exposure to chlorpyrifos caused significant changes in all blood biochemical parameters compared to control groups. Total protein, triglyceride, glucose levels, as well as lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and creatine phosphokinase (CPK) activities in plasma changed after exposure to 10 mg L polyethylene glycol (PEG), while fish exposed to PEG did not show any significant difference in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and acetylcholinesterase (AChE) activities and albumin and globulins levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.12.077DOI Listing
March 2019
4 Reads
3.340 Impact Factor

Dichlorvos alters morphology and behavior in zebrafish (Danio rerio) larvae.

Environ Pollut 2019 Feb 29;245:1117-1123. Epub 2018 Nov 29.

Pontifícia Universidade Católica do Rio Grande do Sul, Escola de Medicina, Programa de Pós-Graduação em Medicina e Ciências da Saúde, Laboratório de Neuroquímica e Psicofarmacologia, Porto Alegre, RS, Brazil; Pontifícia Universidade Católica do Rio Grande do Sul, Escola de Ciências, Programa de Pós-Graduação em Biologia Celular e Molecular, Laboratório de Neuroquímica e Psicofarmacologia, Porto Alegre, RS, Brazil. Electronic address:

Dichlorvos (2,2-dichlorovinyl-dimethylphosphate), an organophosphorus pesticide used for indoor insect and livestock parasite control, is among the most common commercially available pesticides. However, there are significant concerns over its toxicity, especially due to its relative stability in water, soil, and air. Zebrafish, an important developmental model, has been used for studying the effects of toxic compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2018.11.095DOI Listing
February 2019
2 Reads

Molecular characterization of zebrafish Gstr1, the only member of teleost-specific glutathione S- transferase class.

Aquat Toxicol 2019 Mar 9;208:196-207. Epub 2019 Jan 9.

Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Ruđer Bošković Institute, Bijenička 54, 10000, Zagreb, Croatia. Electronic address:

Glutathione S-transferases (GSTs) are multifunctional phase II detoxification enzymes with primary function of glutathione conjugation of various endogenous and exogenous compounds. Teleost-specific Gstr1 in zebrafish (Danio rerio) was previously shown to have high expression in toxicologically relevant tissues and high activity towards model substrates. The aim of this study was a detailed functional characterization of zebrafish Gstr1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.01.005DOI Listing
March 2019
2 Reads

ROS changes are responsible for tributyl phosphate (TBP)-induced toxicity in the alga Phaeodactylum tricornutum.

Aquat Toxicol 2019 Mar 15;208:168-178. Epub 2019 Jan 15.

Department of Marine Ecology, College of Marine Life Science, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Ecology and Environmental Science, Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address:

As a newly emerging environmental contaminant, tributyl phosphate (TBP) is an additive flame retardant of high production volume that is frequently detected in biota and the environment. Despite evidence that TBP is a potential threat to marine organisms, ecotoxicology data for TBP in marine organisms at low trophic levels are scarce. In this study, the acute toxicological effect of TBP on the marine phytoplankton Phaeodactylum tricornutum was thoroughly investigated, and the possible mechanism was explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.01.012DOI Listing
March 2019
2 Reads

Different Toxic Effects of Racemate, Enantiomers, and Metabolite of Malathion on HepG2 Cells Using High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight-Based Metabolomics.

J Agric Food Chem 2019 Feb 8;67(7):1784-1794. Epub 2019 Feb 8.

Commercial malathion is a racemic mixture that contains two enantiomers, and malathion has adverse effects on mammals. However, whether these two enantiomers have different effects on animals remains unclear. In this study, we tested the effect of racemate, enantiomers, and metabolite of malathion on the metabolomics profile of HepG2 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.8b04536DOI Listing
February 2019
3 Reads

OPFRs and BFRs induced A549 cell apoptosis by caspase-dependent mitochondrial pathway.

Chemosphere 2019 Apr 16;221:693-702. Epub 2019 Jan 16.

Key Laboratory of Ministry of Education on Pollution Control and Ecosystem Restoration in Industry Clusters, Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal, School of Environment and Energy, South China University of Technology, Guangzhou, 510006, Guangdong, China.

Organophosphate flame retardants (OPFRs) and brominated flame retardants (BFRs) are frequently detected in indoor environment at high levels, posing health risks to humans. However, the potential cytotoxicity mediated by OPFRs and BFRs in relevant human cell models is limited. In current study, non-small cell lung cancer A549 cell was employed to investigate toxicity mechanisms of typical OPFRs (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.01.074DOI Listing
April 2019
4 Reads

Chemical control of polyphagous pests on their auxiliary hosts can minimize insecticide resistance: A case study of Spodoptera exigua Hübner (Lepidoptera: Noctuidae) in cotton agroecosystem.

Ecotoxicol Environ Saf 2019 Apr 16;171:721-727. Epub 2019 Jan 16.

Department of Entomology, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Multan, Pakistan.

Use of insecticides for agricultural pest management have significant environmental impacts. Using integrated approaches to minimize the frequency of insecticide application by incorporating cultural control tactics can keep environmental hazards to the minimum. The alternate hosts of polyphagous pests have significant role in population development and success of chemical control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.01.038DOI Listing
April 2019
1 Read

Organophosphite Antioxidants in Indoor Dust Represent an Indirect Source of Organophosphate Esters.

Environ Sci Technol 2019 Feb 4;53(4):1805-1811. Epub 2019 Feb 4.

Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , M5S 3H6 , Ontario Canada.

Precise determination of organophosphate esters (OPEs) in the environment is crucial to estimating their potential toxicity effects on human health. Previous studies have mainly focused on OPEs from direct sources. This study explored a potential indirect source of OPEs: the oxidation of organophosphite antioxidants (OPAs). Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.est.8b05545
Publisher Site
http://dx.doi.org/10.1021/acs.est.8b05545DOI Listing
February 2019
10 Reads

Downregulation of carboxylesterase contributes to cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval).

Pest Manag Sci 2019 Jan 17. Epub 2019 Jan 17.

Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, China.

Background: Increased expression or point mutations of carboxyl/cholinesterases (CCEs) have been involved in many cases of insecticide and acaricide resistance. However, it has been only rarely documented that downregulation of CCE genes is associated with resistance, although many insecticides and acaricides need hydrolytic activation in vivo. Previously, expression analysis of a laboratory-selected cyflumetofen-resistant strain of Tetranychus cinnabarinus indicated that resistance was associated with increased expression of a CCE gene of TcCCE04, but also the downregulation of two CCE genes, TcCCE12 and TcCCE23. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ps.5339
Publisher Site
http://dx.doi.org/10.1002/ps.5339DOI Listing
January 2019
12 Reads

Organophosphate Ester, 2-Ethylhexyl Diphenyl Phosphate (EHDPP), Elicits Cytotoxic and Transcriptomic Effects in Chicken Embryonic Hepatocytes and Its Biotransformation Profile Compared to Humans.

Environ Sci Technol 2019 Feb 1;53(4):2151-2160. Epub 2019 Feb 1.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.

The effects of 2-ethylhexyl diphenyl phosphate (EHDPP) on cytotoxicity and mRNA expression, as well as its metabolism, were investigated using a chicken embryonic hepatocyte (CEH) assay. After incubation for 36 h, the lethal concentration 50 (LC) was 50 ± 11 μM, suggesting that EHDPP is one of a small cohort of highly toxic organophosphate esters (OPEs). By use of a ToxChip polymerase chain reaction (PCR) array, we report modulation of 6, 11, or 16/43 genes in CEH following exposure to 0. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.est.8b06246
Publisher Site
http://dx.doi.org/10.1021/acs.est.8b06246DOI Listing
February 2019
10 Reads

Protective Effect of N-Acetyl Cysteine on Chlorpyrifos-Induced Testicular Toxicity in Mice.

Int J Fertil Steril 2019 Apr 6;13(1):51-56. Epub 2019 Jan 6.

Department of Clinical Biochemistry, Babol University of Medical Science, Babol, lran.

Background: Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N-Acetyl Cysteine (NAC), a potent antioxidant against testicular toxicity of CPF in male mice. Read More

View Article

Download full-text PDF

Source
http://ijfs.ir/journal/article/abstract/5494
Publisher Site
http://dx.doi.org/10.22074/ijfs.2019.5494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334019PMC
April 2019
18 Reads

Demonstrating the need for chemical exposure characterisation in a microplate test system: toxicity screening of sixteen pesticides on two marine microalgae.

Chemosphere 2019 Apr 8;221:278-291. Epub 2019 Jan 8.

Ifremer, Laboratoire d'Écotoxicologie, rue de l'île d'Yeu, BP 21105, F-44311 Nantes Cedex 03, France.

Pesticides used in viticulture create a potential risk for the aquatic environment due to drift during application, runoff and soil leaching. The toxicity of sixteen pesticides and one metabolite were evaluated on the growth of two marine microalgae, Tisochrysis lutea and Skeletonema marinoi, in 96-h exposure assays conducted in microplates. For each substance, concentrations of stock solutions were analytically measured and abiotic assays were performed to evaluate the chemical stability of pesticides in microplates. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535193003
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2019.01.035DOI Listing
April 2019
13 Reads