9,517 results match your criteria Toxicity Organophosphate


Potential attenuation of biochemical parameters and enzymatic functions in Cyprinus carpio fingerlings by Phenthoate 50 EC insecticide exposure.

Environ Sci Pollut Res Int 2020 Jun 30. Epub 2020 Jun 30.

Department of Fisheries Biology and Genetics, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.

The risks of the health-associated problems of pesticide-exposed non-target organisms are ubiquitous, therefore an emerging concern to strike the balance between benefit and risk factors. In the present study, by elucidating multiple biomarkers, the effects of Phenthoate 50 EC on the acute toxicity tests and different pathophysiological changes of common carp (Cyprinus carpio) fingerlings were studied in time- and concentration-dependent manners. The LC of Phenthoate 50 EC for the fish was 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-020-09697-xDOI Listing

Genomic effects of a nanostructured alumina insecticide in human peripheral blood lymphocytes in vitro.

Heliyon 2020 Jun 17;6(6):e04216. Epub 2020 Jun 17.

Laboratorio de Biología Tumoral, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro Científico Tecnológico (CCT) Mendoza, Argentina.

Nanotechnology is providing new tools for precision agriculture, such as agrochemical agents and innovative delivery mechanisms to improve cropping efficiency. Powder nanoinsecticides, such as experimental nanostructured alumina (NSA), show great potential for sustainable agriculture as an alternative to conventional synthetic pesticides because their mechanism of insecticide action is based on physical rather than on biochemical phenomena. However, even in highly non-reactive and hardly soluble substances such as alumina, reduced particle size may lead to an increased toxicity of the material. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2020.e04216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305400PMC

The toxicity effects and mechanisms of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and its ecological risk assessment for the protection of freshwater organisms.

Environ Pollut 2020 Sep 14;264:114788. Epub 2020 May 14.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

Tris (1,3-dichloro-2-propyl) phosphate (TDCPP) is a type halogenated organophosphate flame retardants (OPFRs), which has been identified as contaminants of emerging concern (CECs). The use and production of OPFRs began to increase gradually when brominated flame retardants (BFRs) were banned. Halogenated OPFRs, especially TDCPP have been considered to lead to mutagenicity and carcinogenesis and major concerns have been raised regarding their toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2020.114788DOI Listing
September 2020

Fast sample preparation for organo(fluoro)phosphate quantification approaches in lithium ion battery electrolytes by means of gas chromatographic techniques.

J Chromatogr A 2020 Aug 27;1624:461258. Epub 2020 May 27.

University of Münster, MEET Battery Research Center, Corrensstraße 46, 48149Münster, Germany. Electronic address:

Lithium ion batteries are essential power sources in portable electronics, electric vehicles and as energy storage devices for renewable energies. During harsh battery cell operation as well as at elevated temperatures, the electrolyte decomposes and inter alia organo(fluoro)phosphates are formed due to hydrolysis of the conducting salt lithium hexafluorophosphate (LiPF). Since these phosphorus-containing decomposition products possess a potential toxicity based on structural similarities compared to chemical warfare agents, quantification is of high interest regarding safety estimates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2020.461258DOI Listing

Evaluation of Pyrethroids and Organophosphates in Insecticide Mixtures for Management of Western Corn Rootworm Larvae.

Pest Manag Sci 2020 Jun 5. Epub 2020 Jun 5.

Department of Entomology, Iowa State University, Ames, IA, USA, 50011.

Background: The western corn rootworm is an economically important pest of corn. Management tactics include pyrethroid and organophosphate insecticides, which may be applied as a mixture to protect corn roots. The goal of our study was to characterize the effects of pyrethroids and organophosphates alone and in combination on larval corn rootworm mortality and injury to corn roots. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ps.5938DOI Listing

Organophosphate Ester Flame Retardants: Are They a Regrettable Substitution for Polybrominated Diphenyl Ethers?

Environ Sci Technol Lett 2019 Nov 21;6(11):638-649. Epub 2019 Oct 21.

O' Neill School of Public and Environmental Affairs, Indiana University, Bloomington, IN 47401.

As the use of polybrominated diphenyl ethers (PBDEs), and the entire class of organohalogen flame retardants, is declining, the use of organophosphate esters flame retardants (OPFRs) is increasing. In this paper, we ask whether OPFRs are a better choice than PBDEs. To address this question, we compared OPFRs with PBDEs for a wide range of properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.estlett.9b00582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269169PMC
November 2019

Exposure to low doses of malathion during juvenile and peripubertal periods impairs testicular and sperm parameters in rats: Role of oxidative stress and testosterone.

Reprod Toxicol 2020 May 30;96:17-26. Epub 2020 May 30.

Departmentof General Biology, BiologicalSciences Center, StateUniversityof Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, Postal code: 86057-970, Londrina, Paraná, Brazil. Electronic address:

Malathion is an organophosphate insecticide used in agriculture and for controlling vector-borne diseases such as Zika. Humans can be exposed to malathion by means of ingestion of contaminated food. The juvenile and peripubertal periods are a large window of vulnerability to the action of toxic agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2020.05.013DOI Listing

Enantioselective Uptake Determines Degradation Selectivity of Chiral Profenofos in X1.

J Agric Food Chem 2020 Jun 8;68(24):6493-6501. Epub 2020 Jun 8.

Key Laboratory for Agri-Food Safety, School of Resource & Environment, Anhui Agricultural University, Hefei, Anhui 230036, People's Republic of China.

Organophosphorus insecticides account for approximately 28% of the global commercial insecticide market, while 40% of them are chiral enantiomers. Chiral enantiomers differ largely in their toxicities. Enantiomers that are less active or inactive do not offer the needed efficacy but pollute the environment and cause toxicities to non-target species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.0c00132DOI Listing

Effects of triphenyl phosphate on ciliate protozoa Tetrahymena thermophila following acute exposure and sub-chronic exposure.

Ecotoxicol Environ Saf 2020 Sep 23;200:110757. Epub 2020 May 23.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address:

Triphenyl phosphate (TPHP) is one of the most widely used organophosphate flame retardants (OPFRs) and is frequently detected in a variety of environmental media. Previous studies reported that TPHP had toxic effects on vertebrates, but little toxic information was available in lower trophic aquatic organisms which were more sensitive to the exposure of many toxic substances. In this study, protozoa Tetrahymena thermophila (T. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2020.110757DOI Listing
September 2020

Ecotoxicity of chlorpyrifos to aquatic organisms: A review.

Ecotoxicol Environ Saf 2020 Sep 22;200:110731. Epub 2020 May 22.

Ocean College of Hebei Agricultural University, Qinhuangdao, Hebei Province, PR China. Electronic address:

Pesticides play an important role in promoting agricultural development, while their unreasonable use has led to environmental problems. Chlorpyrifos (CPF), a typical organophosphate pesticide, is used globally as an insecticide in agriculture. The extensive application of CPF has resulted in water contamination, and CPF has been detected in rivers, lakes, seawater, and even in rain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2020.110731DOI Listing
September 2020

Assessing the acute toxicity of insecticides to the buff-tailed bumblebee (Bombus terrestris audax).

Pestic Biochem Physiol 2020 Jun 6;166:104562. Epub 2020 Mar 6.

Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK. Electronic address:

The buff-tailed bumblebee, Bombus terrestris audax is an important pollinator within both landscape ecosystems and agricultural crops. During their lifetime bumblebees are regularly challenged by various environmental stressors including insecticides. Historically the honey bee (Apis mellifera spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pestbp.2020.104562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294345PMC

Glyphosate and its toxicology: A scientometric review.

Sci Total Environ 2020 Sep 12;733:139359. Epub 2020 May 12.

Graduate Program in Agroecosystems (PPGSIS), Federal University of Technology-Paraná, Campus Dois Vizinhos (UTFPR-DV), Brazil. Electronic address:

Glyphosate (Gly) is a broad-spectrum herbicide and currently one of the most studied pesticides. New Gly-related data are published daily worldwide. Despite the large number of publications, there is no published scientometric revision that presently addresses this issue systematically. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139359DOI Listing
September 2020

Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain.

Chemosphere 2020 Aug 16;252:126470. Epub 2020 Mar 16.

School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong, 523-808, China. Electronic address:

Concerns have been raised over the neurotoxicity of triphenyl phosphate (TPP), but there have been few studies of the neurotoxic effects of TPP on mammals and the underlying mechanisms. In this study, weaned male mice (C57/BL6) were used and exposed to 0, 50, or 150 mg/kg TPP daily by oral gavage for 30 days. The blood brain barrier (BBB) permeability of TPP and its metabolite diphenyl phosphate (DPP) in the brain, and TPP induced metabolomic and transcriptomic changes of the brain were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126470DOI Listing

miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP).

Environ Pollut 2020 Jul 4;262:114286. Epub 2020 Mar 4.

Department of Energy and Environmental Engineering, Republic of Korea; Department of Environmental Engineering, Seoul National University of Sciences and Technology, Seoul, 01811, Republic of Korea. Electronic address:

Exposure to triphenyl phosphate (TPHP), an organophosphate flame retardants (OPFRs), caused developmental toxicity in zebrafish embryos. However, the underlying molecular mechanism at the epigenetic level is largely unknown. Based on developmental toxicity (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2020.114286DOI Listing

A review of organophosphate flame retardants and plasticizers in the environment: Analysis, occurrence and risk assessment.

Sci Total Environ 2020 Aug 5;731:139071. Epub 2020 May 5.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Environment and Health, Jianghan University, Wuhan, Hubei 430056, China.

Organophosphate esters (OPEs) are used as additives in flame retardants and plasticizers. Due to phase out of several congeners of polybrominated diphenyl ethers (PBDEs), the application of organophosphorus flame retardants (OPFRs) is continuously increasing over the years. As a consequence, large amounts of OPEs enter the environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139071DOI Listing

Systematic mapping of organophosphate contaminant (OPC) research trends between 1990 and 2018.

Environ Geochem Health 2020 May 20. Epub 2020 May 20.

Botany Department, Institute for Coastal and Marine Research, Nelson Mandela University, Port Elizabeth, 6031, South Africa.

Since the addition of polybrominated diphenyls and organochlorine pesticides (OCPs) to the world banned list, toxic organophosphate contaminants (OPCs) such as organophosphate flame retardants and organophosphate pesticides have been, respectively, used as substitutes. These chemicals are reported to be more toxic than their halogenated counterparts. It is rare to find a study that focuses on visualising the publication trends of these chemical classes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10653-020-00594-3DOI Listing

Insecticidal Activity of Strains on the Nettle Caterpillar, (Lepidoptera: Limacodidae).

Insects 2020 May 15;11(5). Epub 2020 May 15.

Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-000, Brazil.

In the present work, we evaluated the insecticidal activity of () strains on as an alternative for the organophosphate insecticide use in oil palm plantations in the Americas. The toxic effects of four -strains (HD-1 var. , SA-12 var. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/insects11050310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290276PMC

Short- and long-term exposure to methamidophos impairs spermatogenesis in mice.

Reprod Biol 2020 May 13. Epub 2020 May 13.

Department of Pharmacology, Laboratory of Physiology and Pharmacology of Reproduction, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Methamidophos (MET) is a pesticide that has toxic properties, including effects on fertility. This study aimed to assess the joint action of treatment time and exposure to methamidophos on the male reproductive system. MET was orally administered to adult male Swiss mice at a dose of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.repbio.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218378PMC

Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells.

Chemosphere 2020 Sep 30;255:126919. Epub 2020 Apr 30.

National Toxicology Program Laboratory, USA. Electronic address:

The predominant reliance on bromated flame retardants (BFRs) is diminishing with expanded use of alternative organophosphate flame retardants. However, exposure related issues for susceptible populations, the developing, infirmed, or aged, remain given environmental persistence and home-environment detection. In this regard, reports of flame retardant (FR)-related effects on the innate immune system suggest process by which a spectrum of adverse health effects could manifest across the life-span. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126919DOI Listing
September 2020

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments.

Authors:
Amira M Badr

Environ Sci Pollut Res Int 2020 May 13. Epub 2020 May 13.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh, 11459, Saudi Arabia.

Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-020-08937-4DOI Listing

Assessment of zebrafish embryo photomotor response sensitivity and phase-specific patterns following acute- and long-duration exposure to neurotoxic chemicals and chemical weapon precursors.

J Appl Toxicol 2020 May 6. Epub 2020 May 6.

U.S. Army Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, Maryland.

Zebrafish are an attractive model for chemical screening due to their adaptability to high-throughput platforms and ability to display complex phenotypes in response to chemical exposure. The photomotor response (PMR) is an established and reproducible phenotype of the zebrafish embryo, observed 24 h post-fertilization in response to a predefined sequence of light stimuli. In an effort to evaluate the sensitivity and effectiveness of the zebrafish embryo PMR assay for toxicity screening, we analyzed chemicals known to cause both neurological effects and developmental abnormalities, following both short (1 h) and long (16 h+) duration exposures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3984DOI Listing

In Vitro Efficacy for Chlorpyrifos Degradation by Novel Isolate Tistrella sp. AUC10 Isolated from Chlorpyrifos Contaminated Field.

Curr Microbiol 2020 May 2. Epub 2020 May 2.

Food Quality Testing Laboratory, N M College of Agriculture, Navsari Agricultural University, Navsari, Gujarat, India.

Chlorpyrifos, an organophosphate (OP) pesticide, possess broad-spectrum insecticidal activity against Lepidoptera, Diptera, Homoptera, Coleoptera, Orthoptera, Hymenoptera, and Hemiptera. Organophosphate pesticides have acute neurotoxicity because they suppress acetylcholine esterase (AChE) which regulates the enzyme of neurotransmitters by reducing acetylcholine concentration at synaptic junctions. On exposure to OP, AChE is inactivated and leads to accumulation of acetylcholine in the junction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00284-020-01998-1DOI Listing

Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds.

Curr Med Chem 2020 Apr 25. Epub 2020 Apr 25.

Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Králové. Czech Republic.

Background: Neurotoxic chemical warfare agents can be classified as some of the most dangerous chemicals for humanity. The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. When AChE is inhibited by OPs, its reactivation can be usually performed through cationic oximes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929867327666200425213215DOI Listing

Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants.

Neuropharmacology 2020 Jul 22;171:108111. Epub 2020 Apr 22.

Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR-10001, Zagreb, Croatia.

The recent advancements in crystallography and kinetics studies involving reactivation mechanism of acetylcholinesterase (AChE) inhibited by nerve agents have enabled a new paradigm in the search for potent medical countermeasures in case of nerve agents exposure. Poisonings by organophosphorus compounds (OP) that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE. An alternative approach to reduce the in vivo toxicity of OP centers on the use of bioscavengers against the parent organophosphate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2020.108111DOI Listing

Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.

Ann N Y Acad Sci 2020 Apr 21. Epub 2020 Apr 21.

Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.

Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Oximes, such as the pyridinium oxime pralidoxime (2-PAM) in the United States, can reactivate the inhibited AChE and restore cholinergic function. However, there are several drawbacks to the current oximes; one of them, the inability of these oximes to effectively enter the brain, is the subject of study by several laboratories, including ours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.14352DOI Listing

Can environmental concentrations of glyphosate affect survival and cause malformation in amphibians? Effects from a glyphosate-based herbicide on Physalaemus cuvieri and P. gracilis (Anura: Leptodactylidae).

Environ Sci Pollut Res Int 2020 Jun 21;27(18):22619-22630. Epub 2020 Apr 21.

Laboratory of Ecology and Conservation, Federal University of Fronteira Sul, Erechim Campus, ERS 135 - Km 72, n°200, Erechim, RS, Brazil.

Herbicides are the most common agrochemicals used in crops. Among them, glyphosate is the most widely applied in the world. Herbicides, especially organophosphates, have been shown to be hazardous to non-target species, including amphibians. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-020-08869-zDOI Listing

The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme Q Status.

Neurochem Res 2020 Apr 18. Epub 2020 Apr 18.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

Organophosphate (OP) compounds are widely used as pesticides and herbicides and exposure to these compounds has been associated with both chronic and acute forms of neurological dysfunction including cognitive impairment, neurophysiological problems and cerebral ataxia with evidence of mitochondrial impairment being associated with this toxicity. In view of the potential mitochondrial impairment, the present study aimed to investigate the effect of exposure to commonly used OPs, dichlorvos, methyl-parathion (parathion) and chloropyrifos (CPF) on the cellular level of the mitochondrial electron transport chain (ETC) electron carrier, coenzyme Q (CoQ) in human neuroblastoma SH-SY5Y cells. The effect of a perturbation in CoQ status was also evaluated on mitochondrial function and cell viability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11064-020-03033-yDOI Listing

Mechanism of interactions between organophosphorus insecticides and human serum albumin: Solid-phase microextraction, thermodynamics and computational approach.

Chemosphere 2020 Aug 7;253:126698. Epub 2020 Apr 7.

Institute of Quality and Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.

Organophosphates insecticides (OPs) are one of the major environmental pollutants and their interaction with human serum albumin (HSA) has been shown to have significant effects on their bioavailability which is related to toxicokinetics and toxicodynamics in human body. In this research, solid-phase microextraction methods were developed to analyse the free concentrations of three OPs (chlorpyrifos, parathion-methyl and malathion) in buffered HSA solution and that provide a useful method for the determination of binding affinity constants (K), binding forces and binding location. Polydimethylsiloxane fibers were selected for analysing the free concentrations of OPs, with an external calibration approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126698DOI Listing

Determining baseline toxicity of ozone against an insecticide-susceptible strain of the common bed bug, Cimex lectularius L. under laboratory conditions.

Pest Manag Sci 2020 Apr 17. Epub 2020 Apr 17.

Department of Entomology, Purdue University, West Lafayette, IN, USA.

Background: Ozone gas is commercially used for deodorization and microbial control. Its efficacy against stored product insect pests is well documented. In the midst of the common bed bug (Cimex lectularius L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ps.5864DOI Listing

Three organophosphate flame retardants (OPFRs) reduce sperm quality in Chinese rare minnows (Gobiocypris rarus).

Environ Pollut 2020 Aug 7;263(Pt A):114525. Epub 2020 Apr 7.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Beijing Key Laboratory of Industrial Wastewater Treatment and Reuse, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:

Organophosphate flame retardants (OPFRs) are widespread in the aquatic environment, but the effects of these chemicals on reproductive toxicity are far from clear. In this study, sperm quality in adult male Chinese rare minnows after exposure to tris-(2-butoxyethyl) phosphate (TBOEP), tris-(1,3-dichloro-2-propyl) phosphate (TDCIPP), and triphenyl phosphate (TPHP) was investigated. No obvious change in sperm concentration and vitality was observed after treatments, whereas significant changes in sperm velocity and morphology were found following all treatments (P < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2020.114525DOI Listing

Concentration and distribution of pesticide residues in soil: Non-dietary human health risk assessment.

Chemosphere 2020 Aug 27;253:126594. Epub 2020 Mar 27.

Soil Physics and Land Management (SLM), Wageningen University and Research, the Netherlands.

Soil contamination by pesticide residues is a primary concern because of the high soil persistence of pesticides and their toxicity to humans. We investigated pesticide concentration and distribution at 3 soil depths in 147 soil samples from agricultural land and assessed potential health risks due to non-dietary human exposure to pesticides in Nepal. About sixty percent of the soil samples had pesticides (25% of the soil samples had single residue, 35% of the soil samples had mixtures of 2 or more residues) in 39 different pesticide combinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126594DOI Listing

Mediation of oxidative stress toxicity induced by pyrethroid pesticides in fish.

Comp Biochem Physiol C Toxicol Pharmacol 2020 Aug 11;234:108758. Epub 2020 Apr 11.

Institute of Animal Molecular Biotechnology, Korea University, Seoul 02841, Republic of Korea; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Organophosphate and organochlorine pesticides are banned in most countries because they cause high toxicity and bioaccumulation in non-target organisms. Pyrethroid pesticides have been applied to agriculture and aquaculture since the 1970s to replace traditional pesticides. However, pyrethroids are approximately 1000 times more toxic to fish than to mammals and birds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpc.2020.108758DOI Listing

Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM.

Chem Biol Interact 2020 Jun 10;324:109092. Epub 2020 Apr 10.

Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910. Electronic address:

Human butyrylcholinesterase (HuBChE) is a stoichiometric bioscavenger that protects from the toxicity of nerve agents. Non-human primates are suitable models for toxicity studies that cannot be performed in humans. We evaluated the biochemical properties of native macaque (MaBChE) tetramers, compared to recombinant MaBChE monomers, PEGylated recombinant MaBChE tetramers and monomers, and native HuBChE tetramers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2020.109092DOI Listing

Biotransformation and oxidative stress responses in relation to tissue contaminant burden in Clarias gariepinus exposed to simulated leachate from a solid waste dumpsite in Calabar, Nigeria.

Chemosphere 2020 Aug 3;253:126630. Epub 2020 Apr 3.

Department of Biology, Norwegian University of Science and Technology (NTNU), Høgskoleringen 5, N-7491, Trondheim, Norway. Electronic address:

In this study, we have investigated biotransformation and oxidative stress responses in relation to tissue contaminant burden in the African sharptooth catfish (Clarias gariepinus) exposed to simulated leachate from a solid waste dumpsite in Calabar, Nigeria. Fish were exposed to simulated leachate, diluted to 0:0 (negative control), 1:10, 1:50, 1:100 and phenanthrene (a PAH: 50 μg/L used as a positive control) for 3, 7 and 14 days. Hepatic transcripts for cat, sod1, gpx1, gr, gst, cyp1a, cyp2d3, and cyp27 were analyzed by real-time PCR, while enzymatic assays for ethoxyresorufin O-deethylase (EROD), buthoxyresorufin O-deethylase (BROD), methoxyresorufin O-deethylase (MROD), pentoxyresorufin O-deethylase (PROD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), uridine diphospho-glucuronosyltransferase (UDPGT) and lipid peroxidase (LPO) were measured using standard methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126630DOI Listing

A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in : Protective Role of Gallic Acid.

Oxid Med Cell Longev 2020 22;2020:3960170. Epub 2020 Mar 22.

Oxidative Stress and Cell Signaling Research Group, Interdisciplinary Research Center on Biotechnology-CIPBIOTEC, Universidade Federal do Pampa, Campus São Gabriel, RS, Brazil.

A. St-Hill popularly known as "velame do campo" is a native species of the savannah from northeastern Brazil, being used in folk medicine due to its beneficial effects in the treatment of many diseases, inflammation, detoxification, gastritis, and syphilis; however, its potential use as an antidote against organophosphorus compound poisoning has not yet been shown. Here, the protective effect of the methanolic fraction of A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3960170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121785PMC

Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats.

Int J Mol Sci 2020 Apr 7;21(7). Epub 2020 Apr 7.

Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.

Flame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential toxicity of these compounds is raising health concerns globally. Organophosphate FRs (OPFRs) are becoming more prevalent as older, brominated FRs are phased out, but the toxicity of these compounds, and the FR mixtures that contain them, is poorly understood. Work in a variety of in vitro model systems has suggested that FRs may induce metabolic reprogramming such that bone density is compromised at the expense of increasing adiposity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21072553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178223PMC

A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health.

Environ Sci Process Impacts 2020 Jun;22(6):1315-1346

University of Iowa, College of Public Health, Iowa City, IA, USA.

Neonicotinoid insecticides are widely used in both urban and agricultural settings around the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements for more toxic compounds, like organophosphates, due in part to their perceived limited potential to affect the environment and human health. This critical review investigates the environmental fate and toxicity of neonicotinoids and their metabolites and the potential risks associated with exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9em00586bDOI Listing

Interactive effects of fish predation and sublethal insecticide concentrations on freshwater zooplankton communities.

Ecotoxicol Environ Saf 2020 Jun 2;196:110497. Epub 2020 Apr 2.

Instituto Nacional de Limnología (CONICET-UNL), Ciudad Universitaria, 3000, Santa Fe, Argentina; Universidad Autónoma de Entre Ríos, Facultad de Ciencia y Tecnología, 3100, Entre Ríos, Argentina.

Stresses imposed by insecticides and predators are possibly the most rigorous filters to which aquatic organisms are exposed in rivers and lakes associated with agricultural lands. However, their interactive effects on zooplankton communities are still unclear. This study elucidated the zooplankton community response to fish predation, the insecticide chlorpyrifos (CLP), and a combination of both factors, using a 30-day mesocosm experiment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2020.110497DOI Listing

Ecotoxicity of malathion pesticide and its genotoxic effects over the biomarker comet assay in Daphnia magna.

Environ Monit Assess 2020 Apr 4;192(5):264. Epub 2020 Apr 4.

Chemistry and Biology Department, Federal Technological University of Paraná, Curitiba, PR, 81280-340, Brazil.

Malathion is a highly toxic organophosphate insecticide, being one of the most widely used in the world and is generally used for insect control in food production. Thus, ecotoxicological studies have been used to verify its toxic effects on aquatic organisms, such as Daphnia magna and biomarkers, as the comet assay. The comet assay is a microgel electrophoresis method for the detection and quantification of DNA strand breaks in individual cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10661-020-8235-0DOI Listing

Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain.

Toxicol Sci 2020 Apr 3. Epub 2020 Apr 3.

Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.

There is a growing need to understand the potential neurotoxicity of organophosphate ester flame retardants (OPFRs) and plasticizers because use and, consequently, human exposure, is rapidly expanding. We have previously shown in rats that developmental exposure to the commercial FR mixture Firemaster® 550 (FM 550), which contains OPFRs, results in sex-specific behavioral effects, and identified the placenta as a potential target of toxicity. The placenta is a critical coordinator of fetal growth and neurodevelopment, and a source of neurotransmitters (NTs) for the developing brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfaa046DOI Listing

Toxic effect and mechanism of tris (1,3-dichloro-2-propyl)phosphate (TDCPP) on the marine alga Phaeodactylum tricornutum.

Chemosphere 2020 Aug 13;252:126467. Epub 2020 Mar 13.

Department of Marine Ecology, College of Marine Life Science, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Ecology and Environmental Science, Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address:

Tris (1,3-dichloro-2-propyl)phosphate (TDCPP) is an organophosphate-based plasticizer and flame retardant with a high production volume. The ubiquitous distribution and persistence of TDCPP in aquatic environment have led to concerns over its possible toxic effects on aquatic organism. However, data regarding the toxicity of TDCPP on algae are limited, and the molecular mechanism remains largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126467DOI Listing

Effects of several organophosphates on hepatic cytochrome P450 activities in rats.

J Vet Med Sci 2020 May 25;82(5):598-606. Epub 2020 Mar 25.

Laboratory of Veterinary Pharmacology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.

Four commonly used organophosphates (fenitrothion, dichlorvos, chlorpyrifos, and trichlorfon) were orally administered to male Sprague-Dawley rats for five days in order to explore their effects on the activities of liver cytochrome P450 (CYP). In addition, Michaelis-Menten kinetics of the metabolic reactions catalyzed by liver CYPs were analyzed following the addition of these compounds to the assay system to examine their potential inhibitory effects on liver CYPs activities. These reactions included ethoxyresorufin O-deethylation, midazolam 4-hydroxylation, tolbutamide hydroxylation, and bufuralol 1'-hydroxylation for CYP1A, 3A, 2C, and 2D activities, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1292/jvms.19-0452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273600PMC

Melatonin Protects Neural Stem Cells Against Tri-Ortho-Cresyl Phosphate-Induced Autophagy.

Front Mol Neurosci 2020 6;13:25. Epub 2020 Mar 6.

Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Key Laboratory of Mental Disorders, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Shandong University, Jinan, China.

Tri-ortho-cresyl phosphate (TOCP) is an extensively used organophosphate in industry. It has been proven to lead to toxicity in different organ systems, especially in the nervous system. Neural stem cells (NSCs) play important roles in both embryonic and adult nervous systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2020.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069477PMC

Impaired pesticide removal and detoxification by biomixtures during the simulated pesticide application cycle of a tropical agricultural system.

Ecotoxicol Environ Saf 2020 Jun 19;195:110460. Epub 2020 Mar 19.

Centro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, 2060, San José, Costa Rica. Electronic address:

Biopurification systems (BPS) or biobeds have been developed to attenuate point-source contamination due to inappropriate pesticide handling or disposal of agricultural wastewaters. The biomixture used for this strategy should be able to remove different active ingredients but its efficiency can vary due to the constant load of pesticides from crop application programs. For that reason, the performance of biomixtures in conditions that mimic the real pesticide treatment before their implementation in field settings should be assayed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2020.110460DOI Listing

Analyzing organophosphate pesticide-serum albumin binding interaction: a combined STD NMR and molecular docking study.

J Biomol Struct Dyn 2020 Mar 31:1-14. Epub 2020 Mar 31.

Department of Chemistry, Indian Institute of Technology Jodhpur, Jheepasani, India.

analysis of the interaction of organophosphate pesticides (OP) with bovine serum albumin (BSA) is crucial to understand their potential effects at the molecular level. In this context, we have employed Saturation Transfer Difference (STD) NMR experiments in conjunction with molecular docking studies to unravel the binding interaction of the OP chlorpyrifos (CPF), diazinon (DZN) and parathion (PA) in solution. The relative STD (%) suggested the detailed epitope mapping of these OP with BSA while the concentration-dependent STD NMR studies were performed to obtain the complex dissociation constant (K) of the OP-BSA complexes; K=1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2020.1745280DOI Listing

Metabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and/or chlorpyrifos.

Ecotoxicol Environ Saf 2020 Jun 14;195:110467. Epub 2020 Mar 14.

Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, PR China. Electronic address:

Heavy metals and pesticides can be easily enriched in food chains and accumulated in organisms, thus pose significant threat to human health. However, their combined effects for long-term exposure at low dose has not been thoroughly investigated; especially there was no biofluid biomarker available to noninvasively diagnose the toxicosis of the combined exposure of the two chemicals at their low levels. In this study, we investigated the change of urine metabolites of rats with 90-day exposure to heavy metal cadmium (Cd) and/or organophosphorus pesticide chlorpyrifos (CPF) using gas chromatography-mass spectrometry (GC-MS)-based metabolomics approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2020.110467DOI Listing

Effects of glyphosate, cypermethrin, and chlorpyrifos on hematological parameters of the tegu lizard (Salvator merianae) in different embryo stages.

Chemosphere 2020 Aug 7;252:126433. Epub 2020 Mar 7.

Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina. Electronic address:

Different studies have demonstrated effects of pesticides during embryo development in vertebrates and stage-dependent effects, but there is no information concerning this for Salvator merianae. We evaluated the effects of the herbicides Glyphosate Roundup (GLY-RU) and Glyphosate Panzer Gold (GLY-PZ); and the insecticides Chlorpyrifos (CPF) and Cypermethrin (CYP), and their complex mixtures, at different concentrations in hematological parameters of S. merianae embryos at two different development stages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126433DOI Listing

Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.

Chemosphere 2020 Jul 6;251:126426. Epub 2020 Mar 6.

Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address:

Organophosphate biocide chlorpyrifos (CPF) is involved with breast cancer. However, the mechanisms remain unknown. CPF increases cell division in MCF-7 cells, by estrogen receptor alpha (ERα) activation, although it is a weak ERα agonist, suggesting other mechanisms should be involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126426DOI Listing

Exposure and post-exposure effects of chlorpyrifos on Carassius auratus gills: An ultrastructural and morphofunctional investigation.

Chemosphere 2020 Jul 6;251:126434. Epub 2020 Mar 6.

Department of Biology, Ecology and Earth Science, University of Calabria, Via P. Bucci 4/B, Rende, Cosenza, 87036, Italy. Electronic address:

Widespread environmental contamination from chlorpyrifos (CPF) is well acknowledged and has led to the proposal to ban or limit its use in agricultural and domestic, within the regulatory context of both America and Europe. Furthermore, great concerns arise as to whether exposure to CPF represents a potential risk to human health. In the present study, by subjecting the goldfish model to three environmentally realistic concentrations of CPF (1, 4, and 8 μg/L) for 96 h, we demonstrated that this pesticide has the potential to induce severe morphological, ultrastructural and functional alterations in gills, even at very low concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2020.126434DOI Listing

DNA methylation changes of apoptotic genes in organogenesis stage of mice embryos by maternal chlorpyrifos induction.

Environ Toxicol 2020 Jul 9;35(7):794-803. Epub 2020 Mar 9.

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

The continued use of pesticides is one of the requirements of modern agriculture. Investigations have shown that pesticides can alter gene methylation and expression and subsequently may lead to abortion or birth of embryos with teratogenic disorders. In present study, 30 female NMRI mouse were divided in three experimental groups which in the CPF group, intraperitoneal chlorpyrifos was injected, in the sham group, DMSO was injected, and the control group without injection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/tox.22915DOI Listing