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Autoimmun Rev 2019 Apr 5. Epub 2019 Apr 5.

Rheumatology Unit, University of Messina, Messina, Italy.

The development of biologics and small oral molecules has recently changed the scenario of pharmacologic treatment of systemic rheumatic diseases and it has become a real revolution. These drugs have innovative mechanisms of action, based on the inhibition of specific molecular or cellular targets directly involved in disease pathogenesis. This new scenario has lead to a regular update of the management recommendations of several institututions, such as those for Rheumatoid Arthritis treatment that address the use of conventional and biologic therapies including TNFin (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, IL-6 inhibitors (tocilizumab and sarilumab), biosimilars and small oral molecules (the JAK inhibitors tofacitinib and baricitinib). Read More

J Biomol Struct Dyn 2019 Mar 19:1-16. Epub 2019 Mar 19.

a Department of Biotechnology , Indian Institute of Technology Roorkee , Roorkee , India.

Drug discovery for a vigorous and feasible lead candidate is a challenging scientific mission as it requires expertise, experience, and huge investment. Natural products and their derivatives having structural diversity are renowned source of therapeutic agents since many years. Tyrosol (a natural phenylethanoid) has been extracted from olive oil, and its structure was confirmed by elemental analysis, FT-IR, FT-NMR, and single crystal X-ray crystallography. Read More

Clin J Am Soc Nephrol 2019 Apr 18;14(4):540-548. Epub 2019 Mar 18.

Department of Pediatrics and Medicine (Nephrology), School of Medicine, University of California, San Diego, La Jolla, California.

Background And Objectives: The neonatal and juvenile human kidney can be exposed to a variety of potentially toxic drugs (, nonsteroidal anti-inflammatory drugs, antibiotics, antivirals, diuretics), many of which are substrates of the kidney organic anion transporters, OAT1 (SLC22A6, originally NKT) and OAT3 (SLC22A8). Despite the immense concern about the consequences of drug toxicity in this vulnerable population, the developmental regulation of OATs in the immature postnatal kidney is poorly understood.

Design, Setting, Participants, & Measurements: Recognizing that today it is difficult to obtain rich data on neonatal kidney handling of OAT probes due to technical, logistic, and ethical considerations, multiple older physiologic studies that used the prototypical organic anion substrate para-aminohippurate (PAH) were reanalyzed in order to provide a quantitative description of OAT-mediated tubular secretion across the pediatric age continuum. Read More

Medicine (Baltimore) 2019 Mar;98(10):e14785

Department of Hematology, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

This study evaluated the efficacy and toxicity of erlotinib and celecoxib (EC) for treating Chinese patients with advanced non-small cell lung cancer (ANSCLC) and epidermal growth factor receptor (EGFR) wild type.Totally, 75 subjects with ANSCLC and EGFR wild type were included. They all underwent EC treatment. Read More

World J Gastroenterol 2019 Feb;25(8):967-979

Institute of Pathology, Ruhr-University Bochum, Bochum 44789, Germany.

Background: Drug toxicity is a common and even serious problem in the gastrointestinal tract that is thought to be caused by a broad spectrum of agents. Although withdrawal of the causative agent would cure the disease knowledge is scarce and mostly derives from case reports and series.

Aim: To investigate potential triggers of drug-induced colitis (DiC). Read More

J Photochem Photobiol B 2019 Apr 22;193:100-108. Epub 2019 Feb 22.

Departamento de química de los materiales, Center Of Soft Matter Research And Technology, SMAT-C, Universidad de Santiago, Av. Bernardo O'Higgins 3363, Estacion Central, Santiago, Chile.

Silver nanoparticles (AgNPs) have been widely recognized as antibacterial agents. However, its stability and activity over time have been poorly studied. In this work, the properties and characteristics of differently stabilized AgNPs were evaluated during a span of time. Read More

J Physiol Pharmacol 2018 Dec 21;69(6). Epub 2019 Feb 21.

Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

Capsaicin-sensitive sensory nerves are densely distributed in the gastrointestinal system and involved in maintenance of gastrointestinal mucosal integrity. capsaicin selectively stimulates nociceptive neurons and its action is mediated through the transient receptor potential channel vanilloid type 1 (TRPV1) receptor. Activation TRPV1 receptors that play a fundamental role in pain signaling, may also exert protective effects against gastrointestinal injury. Read More

Arthritis Rheumatol 2019 Feb 23. Epub 2019 Feb 23.

Division of Preventive Medicine.

Background: While non-steroidal anti-inflammatory drugs (NSAIDs) are used commonly in rheumatology, they cause major toxicity. Improving the risk-benefit ratio requires a more precise understanding of risk.

Methods: We derived and validated a risk score for major toxicity among NSAID users enrolled in a randomized controlled trial. Read More

Eur J Med Chem 2019 Apr 13;167:377-387. Epub 2019 Feb 13.

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address:

The great interest in epithelial-to-mesenchymal transition (EMT) programme lies in its association with process of metastasis and invasion, which is a crucial cause of cancer-related death. Herein, we designed and reported three new NSAID-Pt(IV) prodrugs, taking Non-Steroid Anti-Inflammatory Drugs (NSAIDs) to disrupt EMT programme and assist genotoxic platinum-based drugs as a cytotoxicity booster, to offer a class of potential anticarcinogens with a multi-functional action mechanism. The NSAID-Pt(IV) prodrugs, especially Eto-Pt(IV), highly enhanced cellular uptake with amount up to 42-fold at 3 h compared with CDDP, and greatly increased DNA damage and cell apoptosis, showing much higher cytotoxicity than cisplatin in the tested cancer cells even in A549/cis cells. Read More

J Ethnopharmacol 2019 May 11;235:268-278. Epub 2019 Feb 11.

Department of Physiology, Biosciences Institute, UNESP-São Paulo State University, CEP 18618-689 Botucatu, São Paulo, Brazil. Electronic address:

Ethnopharmacological Relevance: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. Read More

Sci Total Environ 2019 Apr 8;660:751-764. Epub 2019 Jan 8.

Environmental Toxicology Laboratory, School of Chemistry, Autonomous University of the State of Mexico, Intersection of Paseo Colón and Paseo Tollocan, Residencial Colón neighborhood, 50120 Toluca, State of Mexico, Mexico.

Hospital functioning generates a great quantity of contaminants, among which organic materials, heavy metals, and diverse pharmaceuticals are noteworthy that can affect organisms if they are not properly removed from the effluents. The hospital effluent evaluated in the present study came from IMSS (Instituto Mexicano del Seguro Social) Clinic 221 in downtown Toluca, State of Mexico, a secondary care facility. The contaminants identified in hospitals have been associated with deleterious effects on aquatic organisms; however, it is necessary to continue with more studies in order to be able to regulate the production of said contaminants which are generally dumped into the city sewage system. Read More

Environ Pollut 2019 Apr 24;247:638-646. Epub 2019 Jan 24.

Faculty of Science and Technology and Athabasca River Basin Research Institute, Athabasca University, Athabasca, Alberta, Canada; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

Chemical mixtures represent environmentally-realistic exposures of contaminants to aquatic biota. However, there remains a limited understanding of how toxicant mixtures may impact biological function, relative to their individual components. In the current study, oxidative stress responses of the freshwater galaxiid fish inanga (Galaxias maculatus) were examined following exposure to the pro-oxidant trace metal cadmium (2 or 9 μg L), and the anti-oxidant pharmaceutical drug diclofenac (770 μg L), individually or in simple binary mixtures. Read More

Adv Emerg Nurs J 2019 Jan/Mar;41(1):76-85

Vanderbilt University, Nashville, Tennessee.

Salicylates are among the oldest and most widely used medication to date and are utilized for a variety of purposes including the management of fever, inflammation, pain, and cardiovascular prophylaxis. Reports from U.S. Read More

Ter Arkh 2018 Aug;90(8):95-100

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

The review analyzes the main etiological and pathogenetic mechanisms of the development of NSAID-enteropathy. Particular attention is paid to the role of intestinal microbiota in the manifestation and progression of NSAID-enteropathy. The special role of probiotics in the prevention and treatment of NSAIDs enteropathy is considered. Read More

Sci Total Environ 2019 Apr 22;662:607-614. Epub 2019 Jan 22.

Institute of Water Research, University of Granada, Ramón y Cajal, 4, Fray Luis Bldg, ZIP 18071 Granada, Spain; Department of Microbiology, University of Granada, 18071 Granada, Spain. Electronic address:

Diclofenac (DFC) is a common anti-inflammatory drug, and has attracted the significant attention due to its massive use around the world and its environmental impact. In this work, we describe for the first time the use of Penicillium oxalicum, an ascomycetes fungus, for the biotransformation of DFC at flask and bench bioreactor scales. We present a complete study of the role of enzymes, metabolic pathway, acute toxicity assays and comparison between free and immobilised biomass. Read More

Oxid Med Cell Longev 2018 30;2018:9620684. Epub 2018 Dec 30.

Laboratorio de Neurofisiología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico.

Ozone is a harmful tropospheric pollutant, causing the formation of reactive oxygen and nitrogen species that lead to oxidative damage in living beings. NF-B can be activated in response to oxidative damage, inducing an inflammatory response. Nowadays, there are no reliable results that consolidate the use of antioxidants to protect from damage caused by ozone, particularly in highly polluted cities. Read More

Sci Total Environ 2019 Mar 2;657:926-937. Epub 2018 Dec 2.

Department of Biology, Aveiro University, Campus de Santiago, 3810-193 Aveiro, Portugal; Centre for Environmental and Marine Studies (CESAM), Campus de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In the last years the environmental presence of pharmaceuticals has gained increasing attention. Research data show that these compounds can cause toxicological effects in different species of fish, mollusks and macroinvertebrates. However, the literature is scarce in terms of ecotoxicity data especially focusing on plants as test organisms. Read More

Aquat Toxicol 2019 Mar 9;208:146-156. Epub 2019 Jan 9.

Instituto de Ciencias Marinas de Andalucía (CSIC), Campus Rio San Pedro, 11510 Puerto Real, Cádiz, Spain. Electronic address:

The presence of pharmaceuticals in the aquatic ecosystem has become a topic of growing interest in recent years. In this study, the marine clam Ruditapes philippinarum was exposed during 14 days to concentrations close to those found in the environment: (15 μg L) of carbamazepine (CBZ), diclofenac (DCF) and ibuprofen (IBU), three pharmaceuticals widely used worldwide and commonly found within the aquatic environment. Additionally, exposure was followed by a depuration phase (7 days). Read More

Toxicon 2019 Mar 21;159:50-60. Epub 2019 Jan 21.

Instituto Butantan, Laboratório de Fisiopatologia, Av. Dr. Vital Brazil, 1500, 05503-900, São Paulo, SP, Brazil; Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

Victims of Bothrops jararaca snakebites manifest bleedings, blood incoagulability, platelet dysfunction, and thrombocytopenia, and the latter has been directly implicated in the genesis of hemorrhagic diathesis. We addressed herein the direct effects of B. jararaca venom (BjV) on ex vivo platelet aggregation and granule secretion in washed human and mouse platelets. Read More

J Vet Med Sci 2019 Mar 23;81(3):418-424. Epub 2019 Jan 23.

Department of Veterinary Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.

Equine Glandular Gastric Disease (EGGD) is a common disease in sport horses. This disease might be associated with usage of nonsteroidal anti-inflammatory drugs (NSAIDs) for treating inflammatory diseases. Although gastroscopy has been an effective method for diagnosis, but a less invasive, and inexpensive method is preferred. Read More

Int J Nanomedicine 2019 11;14:557-571. Epub 2019 Jan 11.

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China,

Purpose: Rebaudioside A (RA) has nanocarrier characteristics that allow it to self-assemble into micelles in aqueous solutions. The purpose of this study was to determine if a self-nanomicellizing solid dispersion based on RA could be utilized as an oral nano-drug delivery system.

Materials And Methods: Curcumin (Cur) served as a model hydrophobic drug, and a Cur-loaded self-nanomicellizing solid dispersion based on RA (RA-Cur) was formulated. Read More

Int J Nanomedicine 2019 11;14:499-517. Epub 2019 Jan 11.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt,

Background: Lung cancer is the most common cancer and the leading cause of total deaths worldwide. Its classified into two major types including non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) based on the origin of abnormal lung cells as well as the smoking status of the patient. NSCLC is the most common and aggressive type of lung cancer representing 80%-85% of all cases. Read More

Prostaglandins Other Lipid Mediat 2019 04 15;141:1-10. Epub 2019 Jan 15.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt. Electronic address:

We recently reported that celecoxib, a selective cyclooxygenase-2 (COX2) inhibitor, counteracts the adverse circulatory and renal actions of cyclosporine (CSA). Despite the seemingly advantageous nature of this interaction particularly in clinical settings that necessitate the combined use of the two drugs such as immune-related arthritis, the underlying mechanism remains elusive. This prompted us to test the hypothesis that the facilitation of the cystathionine-γ-lyase (CSE)/hydrogen sulfide (HS) signaling accounts for such favorable effects of celecoxib on CSA nephrotoxicity. Read More

Nanotechnology 2019 May 17;30(21):214004. Epub 2019 Jan 17.

Department of Drug Science & Technology, University of Torino, Torino, Italy.

Preventing recurrences and metastasis of prostate cancer after prostatectomy by administering adjuvant therapies is quite a controversial issue. In addition to effectiveness, absence of side effects and long term toxicity are mandatory. Curcuminoids (Curc) extracted with innovative techniques and effectively loaded by polymeric nanobubbles (Curc-NBs) satisfy such requirements. Read More

Exp Mol Pathol 2019 02 6;106:123-130. Epub 2019 Jan 6.

Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. Electronic address:

Background: Diabetic retinopathy (DR) is a common complication of diabetes mellitus, which is a major reason of blindness. Baicalin (BAI) is a flavonoid extracted from Scutellaria baicalensis, whose pharmacological characterizes have been widely reported in various diseases. However, it remains unclear the effect of BAI on DR. Read More

Oxid Med Cell Longev 2018 3;2018:8092713. Epub 2018 Dec 3.

College of Pharmacy, Gachon University, #191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.

Resveratrol, a natural stilbenoid, is produced by several plants, especially grape vines. Its strong potency against obesity, metabolic disorders, vascular disease, inflammation, and various cancers has already been reported. Large amounts of wine or grapes need to be consumed to obtain the amount of resveratrol required for biological activity. Read More

Environ Sci Pollut Res Int 2019 Feb 5;26(6):5704-5712. Epub 2019 Jan 5.

Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, China.

The non-steroidal anti-inflammatory drug (NSAID) diclofenac is one of the most frequently studied as well as controversially discussed pharmaceutically active drug on the subject of its relevance to the environment. This study was conducted to assess the bioconcentration potential of diclofenac and its behavioral and biochemical effects in Daphnia magna. The bioconcentration factors of diclofenac determined after 48 h of aqueous exposure in Daphnia magna were 70. Read More

Regul Toxicol Pharmacol 2019 Mar 3;102:79-89. Epub 2019 Jan 3.

College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam, 330-714, South Korea. Electronic address:

Intra-articular (IA) injection of hyaluronic acid (HA) in combination with nonsteroidal anti-inflammatory drugs, such as ketorolac (KL), have been clinically investigated to provide more rapid and profound pain relief in patients with osteoarthritis. However, its safety, local tolerance, and potential for pharmacokinetic interaction have not been assessed. In this study, the pharmacokinetics and toxicity of a combination of HA and KL were evaluated in normal rats following four-week repeated-dose injection. Read More

Chem Biol Interact 2019 Feb 3;300:18-26. Epub 2019 Jan 3.

Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China. Electronic address:

Chronic pancreatitis is characterized by pancreatic fibrosis, associated with excessive activation of pancreatic stellate cells (PSCs) and increased expression of transforming growth factor-β1 (TGF-β1). Recently, our studies have shown that autophagy inhibitor could inhibit PSCs activation and reduce collagen secretion. Saikosaponin d (SSd), the major active component of bupleurum falcatum (a medicinal plant), has anti-fibrosis effects in liver. Read More

Molecules 2019 Jan 1;24(1). Epub 2019 Jan 1.

Programa de Pós-Graduação em Química Medicinal e Modelagem Molecular, Health Science Institute, Federal University of Pará, Belém 66075-110, PA, Brazil.

A drug design for safer phenylbutazone was been explored by reactivity and docking studies involving single electron transfer mechanism, as well as toxicological predictions. Several approaches about its structural properties were performed through quantum chemistry calculations at the B3LYP level of theory, together with the 6-31+G(d,p) basis sets. Molecular orbital and ionization potential were associated to electron donation capacity. Read More

Mater Sci Eng C Mater Biol Appl 2019 Mar 22;96:302-309. Epub 2018 Nov 22.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

In compression with the intravenous administration, oral delivery most commonly used due to the non-invasive nature and the fact that avoids patient pain and discomfort. By consideration this aim, ibuprofen as a model drug was loaded into two-dimensional tunnels and empty face-centered cubic cubes of Cu-MOF porous through immersing of Cu-MOF in the drug solution. Cu-Based metal-organic framework/ibuprofen nanohybrid (Cu-MOF/IBU) protected with pH-sensitive biopolymeric gelatin microsphere. Read More

Food Funct 2019 Jan;10(1):344-354

Animal Science College, Zhejiang University, Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Hangzhou, 310058, China.

This study evaluated whether resveratrol can alleviate intestinal injury and enhance the mitochondrial function and the mitophagy level in diquat induced oxidative stress of piglets. Twenty-four 35 day old piglets were randomly allocated to four groups: (1) nonchallenged control; (2) control + 100 mg kg-1 resveratrol diet; (3) diquat-treated control and (4) diquat + 100 mg kg-1 resveratrol diet. At the beginning of the experiment, the piglets were injected with diquat or saline (10 mg per kg bodyweight). Read More

Ann Hepatol 2018 Oct;17(6):980-991

Department of Biology, Faculty of Science, Ataturk University, Erzurum, TURKEY.

Introduction And Aim: Indo is widely one of the non-steroidal anti-inflammatory drugs and one of the common toxic effects of this drug is hepatic failure. Thymol is a monoterpene phenol with many different pharmacological activities. However, up to now its hepatoprotective effects on Indo-induced gastric ulcer model in rats have not been explored yet. Read More

Carbohydr Polym 2019 Mar 27;207:276-287. Epub 2018 Nov 27.

ICPEES, Institut de Chimie et Procédé pour l'Energie l'Environnement et la Santé, CNRS UMR 7515, ECPM-Université de Strasbourg, 25 rue Becquerel, 67087 Strasbourg Cedex 2, France. Electronic address:

Hyaluronic acid (HA) is widely investigated due to its high potential for wound dressing applications. The fabrication of biomimetic HA-based scaffolds by electrospinning is thus extensively studied. However, HA is often dissolved in toxic organic solvents to allow the efficient production of electrospun nanofibers. Read More

Molecules 2018 Dec 29;24(1). Epub 2018 Dec 29.

Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in multiple lines of normal cells. Read More

Life Sci 2019 Feb 28;218:224-232. Epub 2018 Dec 28.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States of America. Electronic address:

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly used to control pain, inflammation, and limit the cardinal signs of injury in humans. However, prolonged use of NSAIDs increases the risk of heart attack (myocardial infarction; MI) and the subsequent risk of heart and renal failure. The molecular and cellular mechanism of action for this adverse effect, particularly along the cardiorenal network, is incomplete. Read More

J Biomed Nanotechnol 2019 Feb;15(2):288-300

Nanomaterials-based drug delivery systems display potent applications in cancer therapy. We synthesized a novel anticancer drug, nano-gold loaded with resveratrol (Res-GNPs), which were characterized using UV-Prove, zetasizer and transmission electron microscope. MTT assay, flow cytometry, TUNEL, immunohistochemistry and western blot analysis were performed to explore the antitumor activity of Res-GNPs in liver cancer cells and tumor xenografts. Read More

Molecules 2018 Dec 20;24(1). Epub 2018 Dec 20.

Natural Products Laboratory, School of Health Sciences, University of Brasília, 70910-900, Campus Universitário Darcy Ribeiro, 70910-900 Brasília-DF, Brazil.

The use of natural oils in topical pharmaceutical preparations has usually presented safe agents for the improvement of human health. Based on research into the immense potential of wound management and healing, we aimed to validate the use of topical natural products by studying the ability of the essential oil of DC leaves (oEd) to stimulate in vitro skin cell migration. Skin cytotoxicity was evaluated using a fibroblast cell line (L929) by MTT assay. Read More

Minerva Pediatr 2019 Feb;71(1):82-99

Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

Unlike fever, which is often over-treated especially in children, pain is underestimated and under-treated in pediatric age. The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years. Paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen are the most used at this purpose. Read More

Biomed Pharmacother 2019 Feb 17;110:895-905. Epub 2018 Dec 17.

Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.

Piroxicam (Px) is a non-steroidal anti-inflammatory drug that is widely prescribed in various inflammatory disorders. However, Px is known to induce gastric ulceration and hepato-renal toxicity. Rosuvastatin (ROSV), a member of the statin family, has anti-inflammatory and antioxidant actions independent of its anti-hyperlipidemic action. Read More

Life Sci 2019 Feb 17;218:38-46. Epub 2018 Dec 17.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:

Aims: In the present study, we aimed to evaluate the role of aspirin-triggered resolvin D1 (AT-RvD1) in paraquat (PQ)-induced acute lung injury (ALI) in mice.

Main Methods: We used C57BL/6J mice as experimental subjects to establish mouse models of ALI via intraperitoneal (IP) injection of PQ (28 mg/kg). The mice were then administered AT-RvD1 (10 or 100 ng) via the tail vein 2 h after exposure to PQ and were sacrificed at 72 h post exposure to harvest bronchoalveolar lavage fluid (BALF), blood and lung tissue samples. Read More

Carbohydr Polym 2019 Feb 20;206:694-705. Epub 2018 Nov 20.

Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India. Electronic address:

Multifunctional nanoconjugates possessing an assortment of key functionalities such as magnetism, florescence, cell-targeting, pH and thermo-responsive features were developed for dual drug delivery. The novelty lies in careful conjugation of each of the functionality with magnetic FeO nanoparticles by virtue of urethane linkages instead of silica in a simple one pot synthesis. Further β-cyclodextrin (CD) was utilized to carry hydrophobic as well as hydrophilic drug. Read More

Mar Drugs 2018 Dec 12;16(12). Epub 2018 Dec 12.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Acid-sensing ion channel 3 (ASIC3) makes an important contribution to the development and maintenance of inflammatory and acid-induced pain. We compared different ASIC3 inhibitors (peptides from sea anemones (APETx2 and Ugr9-1) and nonpeptide molecules (sevanol and diclofenac)) in anti-inflammatory action and analgesic effects. All tested compounds had distinct effects on pH-induced ASIC3 current. Read More

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):721-727

Department of Occupational and Environmental Health, School of Public Health, MOE Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To explore the role of mitochondrial biogenesis and the neuroprotective mechanism of resveratrol in fluoride neurotoxicity. SH-SY5Y cells in exponential phase were treated with different concentrations (20, 40, 60 mg/L) of sodium fluoride (NaF) for 24 h. Co-treatment with 60 mg/L NaF, 20 μmol/L resveratrol (RSV) was administrated in the resveratrol intervene trial. Read More

Environ Sci Pollut Res Int 2019 Feb 8;26(4):3659-3665. Epub 2018 Dec 8.

Department of Zoology, Science College, King Saud University, Riyadh, Saudi Arabia.

The ubiquitous use of diazinon (DZN, an organophosphorus insecticide) has increased the probability of occupational, public, and the ecosystem exposure; these exposures are linked to negative health outcomes. The flavonoids curcumin (CUR) and quercetin (QUE) exert significant anti-inflammatory and antioxidant activities against toxicants, including insecticides. However, it is unclear whether their combination enhances these activities. Read More

Biomed Pharmacother 2019 Feb 7;110:554-560. Epub 2018 Dec 7.

Department of Morbid Anatomy & Histopathology, University of Health Sciences, Lahore, Pakistan.

Oxyresveratrol, an active ingredient of Artocarpus lakoocha, is known to possess anti-inflammatory and immunomodulatory properties. Current study investigates the immunomodulatory effect of oxyresveratrol in mouse model of ethanol-induced ulcer. Anti-ulcer effect was determined using histopathological evaluation (H&E staining) and different tests like, gastric ulcer scoring, ulcer index, total acid secretion, and gastric pH. Read More

Eur J Med Chem 2019 Feb 26;163:307-319. Epub 2018 Nov 26.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

A series of resveratrol dimer derivatives against Alzheimer's disease (AD) was obtained by structural modification and transformation using resveratrol as substrate. Biological analysis revealed that these derivatives had moderate inhibitory activity against human monoamine oxidase B (hMAO-B). In particular, 3 and 7 showed the better inhibitory activity for hMAO-B (IC = 3. Read More

Reprod Toxicol 2019 01 5;83:63-72. Epub 2018 Dec 5.

Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Read More

J Neuroinflammation 2018 Dec 8;15(1):338. Epub 2018 Dec 8.

Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, 250012, Shandong Province, People's Republic of China.

Background: Neuroinflammation has recently emerged as a critical risk factor in the pathophysiology of depression. However, the underlying molecular mechanisms and the development of novel therapeutic strategies as means to target these inflammatory pathways for use in the treatment of depression remain unresolved. In the present study, we aimed to investigate the molecular events of neuroinflammation as related to its induction of depression-like behaviors. Read More

Future Med Chem 2018 11 11;10(22):2577-2588. Epub 2018 Dec 11.

National Institute of Laser Enhanced Sciences (NILE), Cairo University, Giza 12613, Egypt.

Aim: There is an urgent need to develop alternative antimicrobial agents and, one of which is via the use of nanotechnology. Green synthetic routes are recently being replaced for nanoparticles preparation. Methods results: Silver-curcumin nanoconjugates (Ag-CurNCs) were prepared in an eco-friendly method. Read More