4,325 results match your criteria Toxicity Neuroleptic Agents


Rapid degradation of clozapine by heterogeneous photocatalysis. Comparison with direct photolysis, kinetics, identification of transformation products and scavenger study.

Sci Total Environ 2019 May 10;665:557-567. Epub 2019 Feb 10.

Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland. Electronic address:

In this study TiO-mediated photocatalytic degradation of the persistent drug clozapine under the simulated solar radiation was studied for the first time. The experiments were conducted both in the ultrapure and river water, which enabled the assessment of the organic matrix impact. The direct and indirect photolysis experiments were conducted for a comparison. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.124DOI Listing
May 2019
4 Reads

Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.

Toxicol Lett 2019 May 22;305:73-80. Epub 2019 Jan 22.

Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany. Electronic address:

New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection. Controlled human studies would of course be best suited but due to ethical reasons and lack of preclinical safety data, they are usually not available. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.01.010DOI Listing
May 2019
4 Reads

Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba.

Sci Total Environ 2019 Mar 2;657:926-937. Epub 2018 Dec 2.

Department of Biology, Aveiro University, Campus de Santiago, 3810-193 Aveiro, Portugal; Centre for Environmental and Marine Studies (CESAM), Campus de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In the last years the environmental presence of pharmaceuticals has gained increasing attention. Research data show that these compounds can cause toxicological effects in different species of fish, mollusks and macroinvertebrates. However, the literature is scarce in terms of ecotoxicity data especially focusing on plants as test organisms. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.002DOI Listing
March 2019
1 Read

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies.

AAPS PharmSciTech 2019 Jan 2;20(1):22. Epub 2019 Jan 2.

Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Sinhgad Technical Education Society, Narhe, Pune, MS, 411041, India.

Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n. Read More

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http://dx.doi.org/10.1208/s12249-018-1213-yDOI Listing
January 2019
10 Reads

A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.

Nat Commun 2018 12 10;9(1):5272. Epub 2018 Dec 10.

Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

Antipsychotic (AP) drugs are used to treat psychiatric disorders but are associated with significant weight gain and metabolic disease. Increased food intake (hyperphagia) appears to be a driving force by which APs induce weight gain but the mechanisms are poorly understood. Here we report that administration of APs to C. Read More

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http://dx.doi.org/10.1038/s41467-018-07684-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288085PMC
December 2018
4 Reads

Poisoning with Tasty and Sweet Seed Pods of Bird of Paradise Plant Caesalpinia gilliessii.

Wilderness Environ Med 2019 Mar 25;30(1):99-100. Epub 2018 Oct 25.

Assistant Professor, Department of Agriculture and Botany, Qazvin Payam Noor University, Iran.

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http://dx.doi.org/10.1016/j.wem.2018.09.001DOI Listing
March 2019
2 Reads

Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction.

Authors:
Rhome L Hughes

Forensic Sci Med Pathol 2019 03 29;15(1):110-113. Epub 2018 Nov 29.

University of North Dakota School of Medicine and Health Sciences, 1301 N. Columbia Rd (Room W430), Grand Forks, ND, 58203, USA.

Kratom is a plant with dose-dependent mixed stimulant and opioid properties whose pharmacologic characteristics and social impact continue to be described. The main active isolate of kratom is mitragynine, an indole-containing alkaloid with opioid-like effects. Kratom toxicity and kratom-associated fatalities have been described, including those in association with additional drugs. Read More

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http://dx.doi.org/10.1007/s12024-018-0049-9DOI Listing
March 2019
3 Reads

Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.

Bioorg Med Chem Lett 2018 Dec 24;28(23-24):3652-3657. Epub 2018 Oct 24.

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States. Electronic address:

Several recent reports have highlighted the feasibility of the use of penfluridol, a well-known antipsychotic agent, as a chemotherapeutic agent. In vivo experiments have confirmed the cytotoxic activity of penfluridol in triple-negative breast cancer model, lung cancer model, and further studies have been proposed to assess its anticancer activity and viability for the treatment of glioblastomas. However, penfluridol anticancer activity was observed at a dosage significantly higher than that administered in antipsychotic therapy, thus raising the concern for the potential onset of CNS side effects in patients undergoing intensive pharmacological treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183083
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http://dx.doi.org/10.1016/j.bmcl.2018.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438620PMC
December 2018
4 Reads
2.420 Impact Factor

Role of food‑drug interactions in neurological and psychological diseases.

Acta Neurobiol Exp (Wars) 2018 ;78(3):187-197

Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara,Turkey.

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food‑drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food‑drug interaction in the treatment of neurological and psychological diseases. Read More

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January 2019
6 Reads

Psychotropic Drugs and Liver Toxicity.

Am J Ther 2018 Sep/Oct;25(5):e601-e602

Hepatology Unit, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/MJT.0000000000000615DOI Listing
March 2019
2 Reads

Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal.

Neurotoxicology 2018 12 28;69:1-10. Epub 2018 Aug 28.

Departamento de Psicologia, Uni-FACEF, 14401-135, Franca, SP, Brazil; Departamento de Psicologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (USP), 14040-901, Ribeirão Preto, SP, Brazil; Instituto de Neurociências e Comportamento-INeC, Campus USP, 14040-901, Ribeirão Preto, SP, Brazil. Electronic address:

Ketamine (KET) is a non-competitive N-Methyl-d-aspartate (NMDA) receptors antagonist that intensifies sensory experiences, prompts hallucinations and delusions, exacerbates previously installed psychosis and disrupts physiological evoked potentials (AEPs). Pharmacologically, KET stimulates glutamate efflux in the medial prefrontal cortex, mainly in the prelimbic (PrL) sub-region. Efferences from this region exert a top-down regulatory control of bottom-up sensory processes either directly or indirectly. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183018
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http://dx.doi.org/10.1016/j.neuro.2018.08.013DOI Listing
December 2018
2 Reads

Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.

Reprod Toxicol 2018 10 24;81:237-245. Epub 2018 Aug 24.

Discipline of Biomedical Sciences, Sydney Medical School, The Unvieristy of Sydney, Sydney, NSW 2006, Australia. Electronic address:

The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. Some human epidemiological studies have associated ondansetron with fetal cardiovascular defects and orofacial clefts. This study investigated the effects of ondanestron on embryonic heart rhythm of gestational day (GD) 13 rat embryos in vitro and then integrated the results with published animal teratology, and animal and human pharmacokinetic studies to perform a risk evaluation. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.08.018DOI Listing
October 2018
5 Reads

Albizia zygia root extract exhibits antipsychotic-like properties in murine models of schizophrenia.

Biomed Pharmacother 2018 Oct 11;106:831-841. Epub 2018 Jul 11.

Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address:

Background: The root extract of Albizia zygia (DC.) J.F. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183262
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http://dx.doi.org/10.1016/j.biopha.2018.07.030DOI Listing
October 2018
6 Reads
2.023 Impact Factor

5-HT parital agonism and 5-HT antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA.

Psychopharmacology (Berl) 2018 Oct 31;235(10):2795-2808. Epub 2018 Jul 31.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward Building 7-014, Chicago, IL, 60611, USA.

Rationale: The effect of atypical antipsychotic drugs (AAPDs), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (CIAS), has been suggested to be due, in part, to enhancing release of dopamine (DA), acetylcholine (ACh), and glutamate (Glu) in cortex and hippocampus. Read More

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http://dx.doi.org/10.1007/s00213-018-4972-yDOI Listing
October 2018
13 Reads

Mutual activation of glutamatergic mGlu and muscarinic M receptors reverses schizophrenia-related changes in rodents.

Psychopharmacology (Berl) 2018 Oct 27;235(10):2897-2913. Epub 2018 Jul 27.

Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna St, 31-343, Kraków, Poland.

Rationale: Metabotropic glutamate receptors and muscarinic M receptors have been proposed as novel targets for various brain disorders, including schizophrenia. Both receptors are coupled to G proteins and are expressed in brain circuits that are important in schizophrenia. Therefore, their mutual activation may be an effective treatment and allow minimizing the doses of ligands required for optimal activity. Read More

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http://link.springer.com/10.1007/s00213-018-4980-y
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http://dx.doi.org/10.1007/s00213-018-4980-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182605PMC
October 2018
12 Reads

Probable mechanisms involved in the antipsychotic-like activity of morin in mice.

Biomed Pharmacother 2018 Sep 20;105:1079-1090. Epub 2018 Jun 20.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Evidence derived from preliminary studies suggests that morin, a neuroactive flavonoid with proven antioxidant and antiinflammatory properties possess antipsychotic-like activity. The present study was designed to evaluate the probable mechanisms involve in the antipsychotic-like activity of morin in ketamine model of schizophrenia. The effects of morin, haloperidol and risperidone on neurobehavioral and anti-schizophrenia-like effects were evaluated in mice (n = 7) following intraperitoneal (i. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.06.057DOI Listing
September 2018
19 Reads
2.023 Impact Factor

Protective effects of Spinacia oleracea seeds extract in an experimental model of schizophrenia: Possible behavior, biochemical, neurochemical and cellular alterations.

Biomed Pharmacother 2018 Sep 19;105:1015-1025. Epub 2018 Jun 19.

Faculty of Medical Sciences, School of Pharmacy, The University of the West Indies, St. Augustine, Trinidad and Tobago. Electronic address:

Schizophrenia is one of the psychotic mental disorders characterized by symptoms of thought, behavior, and social problems. Newer biomedicine and pharmacotherapy has been investigated for the treatment of various neuropsychiatric disorders in the past few decades. Spinacia oleracea is one of these, reported to have beneficial effect against several neurodegenerative disorders. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.06.043DOI Listing
September 2018
3 Reads

Photolytic and photocatalytic transformation of an antipsychotic drug asenapine: Comparison of kinetics, identification of transformation products, and in silico estimation of their properties.

Ecotoxicol Environ Saf 2018 Oct 11;162:272-286. Epub 2018 Jul 11.

Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.

The photolytic and photocatalytic transformation of an antipsychotic drug asenapine with the use of HO and TiO was studied. A method employing irradiation with a simulated full solar spectrum in the photostability chamber was applied, then the reverse-phase ultra high performance liquid chromatography with diode array detector, coupled with electrospray quadrupole time-of-flight mass spectrometer (RP-UHPLC-DAD - ESI-Q-TOF) was used for the quantitative and qualitative analysis of the processes. The developed quantitative method was fully validated, according to the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, and the kinetic parameters of asenapine photodecomposition were compared. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.07.010DOI Listing
October 2018
11 Reads

Cyclosomatostatin- and haloperidol-induced catalepsy in Wistar rats: Differential responsiveness to sleep deprivation.

Neurosci Lett 2018 09 7;684:72-77. Epub 2018 Jul 7.

Timpharm LTD, Moscow, Russia.

Total sleep deprivation (SD) has been found to mitigate motor dysfunctions in Parkinson's disease. Apparently, the similar sensitivity of an animal model for parkinsonism would support the model's validity. Recently, we described catalepsy induced in Wistar rats by somatostatin antagonist, cyclosomatostatin (cSST); this model simulates such a disease-associated abnormality as a fall in brain somatostatin levels. Read More

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http://dx.doi.org/10.1016/j.neulet.2018.07.012DOI Listing
September 2018
1 Read

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).

Behav Brain Funct 2018 Jun 14;14(1):13. Epub 2018 Jun 14.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China.

Background: With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour. Read More

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http://dx.doi.org/10.1186/s12993-018-0145-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001006PMC
June 2018
16 Reads

In vitro screening of selected antiviral drugs against betanodavirus.

J Virol Methods 2018 09 8;259:66-73. Epub 2018 Jun 8.

Division of Aquatic Environment and Health Management, ICAR-Central Institute of Fisheries Education, Mumbai, India. Electronic address:

The inhibitory effects of ammonium chloride (NHCl) and chlorpromazine hydrochloride on betanodavirus were evaluated on Sahul Indian sea bass kidney (SISK) cell line. The cytotoxicity of different concentrations of NHCl (0.1 mM, 1 mM, 10 mM, 100 mM and 500 mM) and chlorpromazine hydrochloride (1 μM, 10 μM, 100 μM, 200 μM and 500 μM) were assessed in SISK cells using different cytotoxic assays. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.06.005DOI Listing
September 2018
21 Reads

Successful intravenous lipid emulsion therapy: Olanzapine intoxication.

Acute Med 2018 ;17(2):96-97

Haseki Training and Research Hospital, Department of Emergency Medicine, Istanbul, Turkey.

Olanzapine is an antipsychotic drug used in psychiatric diseases. At high doses it exhibits cardiovascular and neurological sideeffects in particular. Lipid emulsion therapy for the removal of medication from plasma in high-dose lipophilic drug use has recently become very widespread. Read More

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October 2018
9 Reads

[Side Effects of Smoking Cessation].

Praxis (Bern 1994) 2018 Jun;107(12):655-657

1 Psychiatrische Klinik, Regionalspital Emmental, Langnau im Emmental.

Side Effects of Smoking Cessation Abstract. We present the case of a clozapine intoxication associated with aspiration pneumonia due to smoking cessation. Clozapine is mainly metabolized by CYP1A2. Read More

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http://dx.doi.org/10.1024/1661-8157/a002991DOI Listing
June 2018
4 Reads

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs.

Cardiovasc Toxicol 2018 12;18(6):530-536

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have been noticed in patients who were given antidepressant, anticonvulsant, and/or antipsychotic drugs besides lithium. In this study, we assessed cardiohemodynamic and electrophysiological effects of lithium carbonate by itself to begin to analyze onset mechanisms of its cardiovascular side effects. Read More

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http://dx.doi.org/10.1007/s12012-018-9464-0DOI Listing
December 2018
6 Reads

Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance.

Front Endocrinol (Lausanne) 2018 23;9:144. Epub 2018 Apr 23.

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.

Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells. Read More

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http://dx.doi.org/10.3389/fendo.2018.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924798PMC
April 2018
4 Reads

Clozapine toxicity in a CYP2D6 poor metaboliser: Additive effects of haloperidol and valproate on clozapine metabolism.

Australas Psychiatry 2018 Dec 8;26(6):608-611. Epub 2018 May 8.

Clinical Chemistry Registrar, NSW Health Pathology, The Prince of Wales Hospital, Randwick, NSW, Australia.

Objective:: To illustrate the complexities of clozapine metabolism with the use of therapeutic drug monitoring.

Methods:: We describe a case of clozapine toxicity in a patient with schizophrenia treated with the combination of clozapine, valproate and haloperidol.

Results:: A 24-year-old CYP2D6 poor metaboliser developed clozapine toxicity corresponding to the additive effects of haloperidol, and increasing clozapine and valproate doses. Read More

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http://journals.sagepub.com/doi/10.1177/1039856218771509
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http://dx.doi.org/10.1177/1039856218771509DOI Listing
December 2018
12 Reads

LL-37-induced human osteoblast cytotoxicity and permeability occurs independently of cellular LL-37 uptake through clathrin-mediated endocytosis.

Biochem Biophys Res Commun 2018 06 5;501(1):280-285. Epub 2018 May 5.

Department of Experimental Medical Science, Lund University, BMC D12, SE-221 84, Lund, Sweden. Electronic address:

The host defense peptide LL-37 is cytotoxic for bacteria but it has also been reported to reduce host cell viability through an intracellular mechanism. LL-37-evoked cytotoxicity may be involved in the loss of bone tissue in periodontitis which is an inflammatory disease characterized by high concentrations of LL-37 observed locally in the periodontal tissue at the inflammation process. Here, we showed that LL-37 reduced human osteoblast-like MG63 cell viability assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and increased plasma membrane permeability determined by measuring intracellular Ca levels and lactate dehydrogenase (LDH) release. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.04.235DOI Listing
June 2018
4 Reads

Selegiline Nanoformulation in Attenuation of Oxidative Stress and Upregulation of Dopamine in the Brain for the Treatment of Parkinson's Disease.

Rejuvenation Res 2018 Oct 21;21(5):464-476. Epub 2018 Jun 21.

1 Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University) , New Delhi, India .

Objective of this study was to determine whether the prepared nanoemulsion would be able to deliver selegiline to the brain by intranasal route, improving its bioavailability. Antioxidant activity, pharmacokinetic parameters, and dopamine concentration were determined. Oxidative stress models, which had Parkinson's disease-like symptoms, were used to evaluate the antioxidant activity of nanoemulsion loaded with selegiline in vivo. Read More

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http://dx.doi.org/10.1089/rej.2017.2035DOI Listing
October 2018
2 Reads

The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep.

PLoS Biol 2018 04 13;16(4):e2002909. Epub 2018 Apr 13.

Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.

The rostromedial tegmental nucleus (RMTg), also called the GABAergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. Whether the RMTg is involved in sleep-wake regulation is unknown. In the present study, pharmacogenetic activation of rat RMTg neurons promoted non-rapid eye movement (NREM) sleep with increased slow-wave activity (SWA). Read More

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http://dx.doi.org/10.1371/journal.pbio.2002909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919677PMC
April 2018
8 Reads

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.

Psychopharmacology (Berl) 2018 05 11;235(5):1593-1607. Epub 2018 Apr 11.

Allergan, Madison, NJ, USA.

Rationale: Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry.

Objectives: The study aims to compare the effects of cariprazine and aripiprazole on PCP-induced changes in the extracellular levels of glutamate, dopamine, serotonin, noradrenaline, and GABA in the rat medial prefrontal cortex (mPFC), and on locomotor activation. Read More

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http://dx.doi.org/10.1007/s00213-018-4874-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920013PMC
May 2018
10 Reads

Investigation of the photolysis and TiO, SrTiO, HO-mediated photocatalysis of an antipsychotic drug loxapine - Evaluation of kinetics, identification of photoproducts, and in silico estimation of properties.

Chemosphere 2018 Aug 5;204:1-10. Epub 2018 Apr 5.

Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Łodź, Poland.

The photolytic and photocatalytic transformation of loxapine with the use of HO, TiO and SrTiO under the simulated solar radiation was studied. A micro-scale method for simultaneous irradiation of multiple samples in photostability chamber was applied. RP-UHPLC-DAD coupled with ESI-Q-TOF mass spectrometer was used for the quantitative and qualitative analysis of the processes. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.04.022DOI Listing
August 2018
10 Reads

-Theanine Decreases Orofacial Dyskinesia Induced by Reserpine in Rats.

Neurotox Res 2018 Oct 9;34(3):375-387. Epub 2018 Apr 9.

Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, B1F., No. 95, Wen-Chang Road, Shih-Lin District, Taipei City, 11101, Taiwan, Republic of China.

Reserpine (RES)-induced orofacial dyskinesia (OD) has been used as an animal model for human tardive dyskinesia (TD) for decades, due to its strong pathophysiological association with striatal oxidative stress and neural cytoarchitecture alteration. -Theanine (LT), one of the major amino acid components in green tea, has potent antioxidative, anti-inflammatory, and neuroprotective effects. In this study, we examined the potential protective effects of LT on RES-induced behavioral and neurochemical dysfunction in rats. Read More

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http://dx.doi.org/10.1007/s12640-018-9897-zDOI Listing
October 2018
8 Reads

Endocrinopathies and renal outcomes in lithium therapy: impact of lithium toxicity.

QJM 2017 Dec;110(12):821-827

From the Department of Endocrinology.

Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects.

Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Read More

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http://dx.doi.org/10.1093/qjmed/hcx171DOI Listing
December 2017
12 Reads

Antinociceptive and anti-inflammatory effects of 1,2-bis-(4 methoxyphenylselanyl) styrene in mice: involvement of the serotonergic system.

J Pharm Pharmacol 2018 Jul 27;70(7):901-909. Epub 2018 Mar 27.

Grupo de Pesquisa em Neurobiotecnologia - GPN- Centro de Desenvolvimento Tecnológico, CDTec, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil.

Background: Pain is one of the most prevalent, costly and disabling conditions that reduces quality of life. Although there are many analgesics available, there is some concern regarding their efficacy, safety and side effects. Organic selenium compounds are attractive targets of various research groups due to their pharmacological properties. Read More

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http://dx.doi.org/10.1111/jphp.12907DOI Listing
July 2018
3 Reads

Cannabinoid Hyperemesis Syndrome: Public Health Implications and a Novel Model Treatment Guideline.

West J Emerg Med 2018 Mar 8;19(2):380-386. Epub 2017 Nov 8.

University of California, San Diego, Department of Emergency Medicine, San Diego, California.

Introduction: Cannabinoid hyperemesis syndrome (CHS) is an entity associated with cannabinoid overuse. CHS typically presents with cyclical vomiting, diffuse abdominal pain, and relief with hot showers. Patients often present to the emergency department (ED) repeatedly and undergo extensive evaluations including laboratory examination, advanced imaging, and in some cases unnecessary procedures. Read More

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http://dx.doi.org/10.5811/westjem.2017.11.36368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851514PMC
March 2018
18 Reads

The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance.

Toxicol Appl Pharmacol 2018 04 15;345:66-74. Epub 2018 Mar 15.

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

Cumulative evidence has suggested that many antipsychotics cause metabolic abnormalities. Adipose tissue insulin resistance (Adipo-IR) contributes to the development and progress of metabolic abnormalities including fatty liver by inducing excessive free fatty acid release from adipose tissue. Sulpiride is an old antipsychotic still frequently used in many developing countries. Read More

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http://dx.doi.org/10.1016/j.taap.2018.02.023DOI Listing
April 2018
4 Reads

Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice.

Brain Res Bull 2018 05 13;139:292-306. Epub 2018 Mar 13.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

GABAergic (Gamma-aminobutyric acid) and neurotrophic derangements have important implication in schizophrenia, a neuropsychiatric disease. Previous studies have shown that nicotinamide adenine dinucleotide phosphate oxidase (NADPH-oxidase) alters GABAergic and neurotrophic activities via inflammatory and oxidative pathways. Thus, it has been proposed that agents with anti-oxidant and anti-inflammatory properties might be beneficial for the treatment of the disease. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.03.006DOI Listing
May 2018
11 Reads
2.720 Impact Factor

Antipsychotic drug poisoning monitoring of clozapine in urine by using coffee ring effect based surface-enhanced Raman spectroscopy.

Anal Chim Acta 2018 Jul 20;1014:64-70. Epub 2018 Feb 20.

Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China. Electronic address:

Antipsychotics are the drugs most often involved in drug poisoning cases, and therefore, therapeutic drug monitoring (TDM) is necessary for safe and effective medication administration of these drugs. In this study, a coffee ring effect-based surface-enhanced Raman spectroscopy (CRE-SERS) method was developed and successfully used to monitor antipsychotic poisoning by using urine samples for the first time. The established method exhibited excellent SERS performance since more hot spots were obtained in the "coffee ring". Read More

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http://dx.doi.org/10.1016/j.aca.2018.02.027DOI Listing
July 2018
15 Reads

Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron.

Int J Environ Res Public Health 2018 02 27;15(3). Epub 2018 Feb 27.

School of Public Health, 3rd Floor, SRM Medical College and Research, Centre, Kattankulathur 603211, India.

Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i. Read More

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http://dx.doi.org/10.3390/ijerph15030414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876959PMC
February 2018
33 Reads
2.060 Impact Factor

The therapeutic potential of metabotropic glutamate receptor modulation for schizophrenia.

Curr Opin Pharmacol 2018 02 24;38:31-36. Epub 2018 Feb 24.

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

Accumulating evidence suggests that a dysregulation of the glutamatergic system exists in the brains of schizophrenia patients. The metabotropic glutamate (mGlu) receptors are being investigated as novel drug targets for this disease, and have shown promise in both preclinical and clinical studies. Activation of mGlu receptors may be efficacious for several symptom domains (positive, negative, and cognitive) and the potential for targeting mGlu receptors has been bolstered by recent research on mitigating toxicity profiles associated with mGlu activation. Read More

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http://dx.doi.org/10.1016/j.coph.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949078PMC
February 2018
7 Reads

The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task.

Psychopharmacology (Berl) 2018 05 22;235(5):1403-1414. Epub 2018 Feb 22.

Gedeon Richter Plc, Budapest, Hungary.

Rationale: Attentional processing deficits are a core feature of schizophrenia, likely contributing to the persistent functional and occupational disability observed in patients with schizophrenia. The pathophysiology of schizophrenia is hypothesized to involve dysregulation of NMDA receptor-mediated glutamate transmission, contributing to disruptions in normal dopamine transmission. Preclinical investigations often use NMDA receptor antagonists, such as phencyclidine (PCP), to induce cognitive disruptions relevant to schizophrenia. Read More

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http://dx.doi.org/10.1007/s00213-018-4857-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920008PMC
May 2018
4 Reads

Therapeutic drug monitoring of atypical antipsychotics.

Psychiatr Pol 2017 Dec 30;51(6):1059-1077. Epub 2017 Dec 30.

Klinika Psychiatrii Dorosłych Gdańskiego Uniwersytetu Medycznego.

The paper presents an overview and analysis of the results of research on therapeutic ranges of concentrations and receptor occupancy, mainly D2 receptors, in the treatment with some atypical antipsychotic drugs. Amisulpride, aripiprazole, clozapine, quetiapine, olanzapine, risperidone, paliperidone, sertindole, and ziprasidone were taken into account. The benefits of therapeutic drug monitoring to optimize the effectiveness of treatment and avoid side effects or toxicity were shown. Read More

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http://dx.doi.org/10.12740/PP/65307DOI Listing
December 2017
3 Reads

Doxycycline prevents and reverses schizophrenic-like behaviors induced by ketamine in mice via modulation of oxidative, nitrergic and cholinergic pathways.

Brain Res Bull 2018 05 6;139:114-124. Epub 2018 Feb 6.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, PMB 5017, Oyo State, Nigeria.

The involvement of oxidative, nitrergic, cholinergic and inflammatory alterations have been reported to contribute to the pathophysiology of schizophrenia, a debilitating neuropsychiatric disorder. Our previous studies have shown that doxycycline (DOX), a notable member of tetracyclines with proven antioxidant and anti-inflammatory properties, attenuated psychotic-like behaviors induced by apomophine and ketamine (KET) in mice. This present study was designed to further evaluate in detail the ability of DOX and its combination with risperidone (RIS) to prevent and reverse KET-induced schizophrenic-like behaviors and the role of oxidative/nitrergic and cholinergic pathways in mice. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.02.007DOI Listing
May 2018
12 Reads
2.720 Impact Factor

Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents.

Pharmacol Res Perspect 2018 02;6(1)

CNS Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.

Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D receptor antagonism. TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] is a novel phosphodiesterase 10A inhibitor that activates both direct and indirect pathway MSNs through increasing both cAMP and cGMP levels by inhibition of their degradation. The activation of indirect pathway MSNs through the distinct mechanism of action of these drugs raises the possibility of augmented pharmacological effects by combination therapy. Read More

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http://dx.doi.org/10.1002/prp2.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817828PMC
February 2018
5 Reads

Carvacrol prevents impairments in motor and neurochemical parameters in a model of progressive parkinsonism induced by reserpine.

Brain Res Bull 2018 05 4;139:9-15. Epub 2018 Feb 4.

Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra pars compact (SNpc), with consequent depletion of dopamine in the striatum, which gives rise to the characteristic motor symptoms of PD. Although its etiology is unknown, several studies have suggested that oxidative stress plays a critical function in the pathophysiology of PD, and antioxidant agents could be helpful to slown down the dopaminergic neurodegeneration. Carvacrol (CA) is a phenolic monoterpene found in essential oils of many aromatic plants that presents antioxidant and neuroprotective effects. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.01.017DOI Listing
May 2018
7 Reads

Protective Effect of L-Theanine on Haloperidol-Induced Orofacial.

Chin J Physiol 2018 Feb;61(1):35-41

Department of Psychiatry, Yuan-Shan Br. of Taipei Veteran General Hospital, Yilan County 26604, Taiwan, Republic of China.

Tardive dyskinesia (TD) is a severe side effect of chronic neuroleptic treatment consisting of abnormal involuntary movements, characterized by orofacial dyskinesia (OD). Haloperidol (HAL)- induced OD has been widely used as an animal model to study the neuropathophysiology of human TD with its pathophysiology strongly associated with striatal oxidative stress. L-Theanine (LT), one of the major amino acid components in green tea, has potent antioxidative effects and is able to protect against various oxidative injuries. Read More

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http://dx.doi.org/10.4077/CJP.2018.BAG529DOI Listing
February 2018
4 Reads

Gabapentin reduces haloperidol-induced vacuous chewing movements in mice.

Pharmacol Biochem Behav 2018 03 31;166:21-26. Epub 2018 Jan 31.

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil. Electronic address:

Tardive dyskinesia (TD) is a common adverse effect observed in patients with long-term use of typical antipsychotic medications. A vacuous chewing movement (VCM) model induced by haloperidol has been used to study these abnormalities in experimental animals. The cause of TD and its treatment remain unknown, but several lines of evidence suggest that dopamine receptor supersensitivity and gamma-aminobutyric acid (GABA) insufficiency play important roles in the development of TD. Read More

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http://dx.doi.org/10.1016/j.pbb.2018.01.003DOI Listing
March 2018
49 Reads

Neuroleptic Malignant Syndrome: Diagnosis and Management.

Prim Care Companion CNS Disord 2018 Jan 4;20(1). Epub 2018 Jan 4.

Department of Community Health and Family Medicine, 1707 N Main St, Gainesville, FL 32609.

Objective: To provide an overview of neuroleptic malignant syndrome (NMS) for the general practitioner with the most up-to-date information on etiology, workup, and management.

Data Sources: The search using PubMed included articles with the key words neuroleptic malignant syndrome, antipsychotics, neuroleptics, diagnosis, and treatment of neuroleptic malignant syndrome published in English from January 2000 to 2017. Single-case reports and articles dealing with the pediatric patient population were excluded. Read More

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http://dx.doi.org/10.4088/PCC.17r02185DOI Listing
January 2018
2 Reads