4,435 results match your criteria Toxicity Neuroleptic Agents


Clozapine Improves Behavioral and Biochemical Outcomes in a MK-801-Induced Mouse Model of Schizophrenia.

J Environ Pathol Toxicol Oncol 2020 ;39(1):1-12

Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.

Glutamatergic N-methyl-D-aspartate (NMDA) receptors have critical roles in several neurological and psychiatric diseases. Dizocilpine (MK-801) is a ligand at phencyclidine recognition sites that is associated with NMDA receptor-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate receptors. In this study, we investigate the effect of clozapine on MK-801-induced neurochemical and neurobehavioral alterations in the prefrontal cortex of mice. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2019030362DOI Listing

Daphnia magna responses to fish kairomone and chlorpromazine exposures.

Chem Biol Interact 2020 Jul 7;325:109123. Epub 2020 May 7.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18, 08034, Barcelona, Spain.

To avoid being preyed, organisms must be able to identify predatory threats by sensing molecules released by predators (kairomones), and to employ effective strategies to prevent detection by predators. Furthermore, in the wild, organisms are also exposed to chemicals that may alter their behavioral traits, such as neuroactive pharmaceuticals. Considering the co-occurrence of both types of chemicals, their possible interaction needs to be studied. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109123DOI Listing

Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity.

Drug Res (Stuttg) 2020 Jun 4;70(6):265-272. Epub 2020 May 4.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The link between Ca dysregulation, mitochondria damages, oxidative stress and cellular derangement is particularly evident in neurotoxicity induced by chemotherapeutic agents. In the current study, we investigated effects of trifluoperazine (TFP) as an inhibitor of calmodulin against the cytotoxicity induced by cytarabine (Ara-C) and Ifosfamide (IFOS) on isolated rat neurons and also the mechanisms involved in this toxicity. Isolated rat neurons were pretreated with TFP (100 µM) for 5 min at 37°C, then Ara-C (226 µM) and IFOS (290 µM) were added in separate experiments. Read More

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http://dx.doi.org/10.1055/a-1154-8672DOI Listing

Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3β and Wnt/β-catenin signaling pathways.

Life Sci 2020 May 7;249:117535. Epub 2020 Mar 7.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Aim: Schizophrenia is a chronic, disabling and one of the major neurological illnesses affecting nearly 1% of the global population. Currently available antipsychotic medications possess limited effects. The current research aimed at investigating potential therapeutic add-on benefit to enhance the effects of clozapine anti-schizophrenic. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117535DOI Listing

Catatonia Due to Tacrolimus Toxicity 16 Years After Renal Transplantation: Case Report and Literature Review.

J Psychiatr Pract 2019 Nov;25(6):481-484

SIKAVI: Department of Psychiatry, Harvard Medical School, Boston, MA MCMAHON, FROMSON: Department of Psychiatry, Harvard Medical School, Harvard Longwood Psychiatry Residency Training Program, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, and Department of Psychiatry, Brigham and Women's Hospital, Boston, MA.

Tacrolimus, a potent posttransplant immunosuppressant, has been associated with major neuropsychiatric complications, including catatonia and psychosis. We report a novel case of tacrolimus-induced encephalopathy that developed 16 years after renal transplantation while the drug was at a therapeutic level. Discontinuation of tacrolimus and switching to an alternative immunosuppressant resulted in significant clinical improvement over 1 week. Read More

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http://dx.doi.org/10.1097/PRA.0000000000000425DOI Listing
November 2019

Study of the possible synergistic protective effects of Melatonin and Pregabalin in Vincristine induced peripheral neuropathy Wistar Albino rats.

Life Sci 2020 Mar 7;244:117095. Epub 2019 Dec 7.

Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.

Aims: Investigate Melatonin administration along with Vincristine (VCR) owing to two reasons: First, Melatonin's sciatic nerve protective effect against Chemotherapy Induced Peripheral Neuropathy (CIPN). Second, Vincristine's anticancer work potentiation that may lead to a decrease in its dose and its side effects accordingly.

Main Methods: In vivo and in vitro experiments were conducted in the study. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.117095DOI Listing
March 2020
2.702 Impact Factor

Circulating microRNA as biomarkers of clozapine-induced cardiotoxicity.

Biomarkers 2020 Feb 21;25(1):76-85. Epub 2019 Nov 21.

Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

This work investigated the utility of circulating microRNA (miRNA) as biomarkers of clozapine (CLZ)-induced cardiotoxicities: serious adverse events with an unusually high incidence in Australia and New Zealand. Global plasma miRNA expression was analysed by microarray in patients taking CLZ, to investigate differential expression between CLZ-induced cardiotoxicity cases ( = 6) and matched control patients ( = 12). The results were validated by RT-qPCR using a panel of 17 miRNA, and their expression was examined in both CLZ-naïve healthy volunteers ( = 12) and an expanded cohort of CLZ-taking patients ( = 21). Read More

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http://dx.doi.org/10.1080/1354750X.2019.1693631DOI Listing
February 2020

Comparison of plasma, saliva, and hair lamotrigine concentrations.

Clin Biochem 2019 Dec 28;74:24-30. Epub 2019 Oct 28.

Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland.

Background: In some clinical situations (pregnancy, aging, drug resistance, toxicity), measurements of lamotrigine plasma levels may be reliable. Limited studies indicate that saliva and hair could be alternative sources for monitoring lamotrigine therapy. The drug content in hair can also be used to assess the history of drug therapy and to ascertain long-term patient compliance. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.09.009DOI Listing
December 2019
1 Read

In vitro and in vivo toxicity evaluation of non-neuroleptic phenothiazines, antitubercular drug candidates.

Regul Toxicol Pharmacol 2019 Dec 28;109:104508. Epub 2019 Oct 28.

Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

The phenothiazine-derived antipsychotic drugs, such as chlorpromazine and thioridazine, are bactericidal against drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis, but produce undesirable side effects at clinically relevant doses. We have previously modified four novel phenothiazines and maintained their antimycobacterial activity. This study evaluated the pharmacological and toxicity profiles of these novel non-neuroleptic phenothiazines, PTZ3, PTZ4, PTZ31 and PTZ32, for their metabolic stability, kinetic solubility and potential cytotoxic effects in vitro. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.104508DOI Listing
December 2019
1 Read

The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review.

Br J Anaesth 2020 01 22;124(1):44-62. Epub 2019 Oct 22.

Department of Anaesthesia, Royal North Shore Hospital of Sydney, Sydney, NSW, Australia; Northern Clinical School, University of Sydney, Sydney, NSW, Australia.

Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter system. Common serotonergic drugs include many antidepressants, antipsychotics, and opioid analgesics, particularly fentanyl, tramadol, meperidine (pethidine), and methadone, but rarely morphine and other related phenanthrenes. Symptoms of serotonin toxicity are attributable to an effect on monoaminergic transmission caused by an increased synaptic concentration of serotonin. Read More

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http://dx.doi.org/10.1016/j.bja.2019.08.010DOI Listing
January 2020
1 Read

Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

Epilepsia 2019 11 13;60(11):2314-2324. Epub 2019 Oct 13.

4Brain, Department of Neurology, Ghent University, Ghent, Belgium.

Objective: More than one-third of patients with temporal lobe epilepsy (TLE) continue to have seizures despite treatment with antiepileptic drugs, and many experience severe drug-related side effects, illustrating the need for novel therapies. Selective expression of inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) allows cell-type-specific reduction of neuronal excitability. In this study, we evaluated the effect of chemogenetic suppression of excitatory pyramidal and granule cell neurons of the sclerotic hippocampus in the intrahippocampal mouse model (IHKA) for temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1111/epi.16368DOI Listing
November 2019
1 Read

Sustained delivery of olanzapine from sunflower oil-based polyol-urethane nanoparticles synthesised through a cyclic carbonate ring-opening reaction.

IET Nanobiotechnol 2019 Sep;13(7):703-711

Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran.

The forefront horizon of biomedical investigations in recent decades is parcelling-up and delivery of drugs to achieve controlled/targeted release. In this regard, developing green-based delivery systems for a spatiotemporal controlling therapeutic agent have drawn a lot of attention. A facile route based on cyclic carbonate ring-opening reaction has been utilised to synthesise a bio-based polyol-containing urethane bond [polyol-urethane (POU)] as a nanoparticulate drug delivery system of olanzapine in order to enhance its bioavailability. Read More

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http://dx.doi.org/10.1049/iet-nbt.2018.5440DOI Listing
September 2019
1 Read
1.500 Impact Factor

Effects of clozapine and haloperidol treatment on plasma concentrations of androgen hormones and androgendependent organ changes in rats.

Indian J Pharmacol 2019 Jul-Aug;51(4):269-275

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.

Objectives: Metabolic and endocrine adverse effects are among the most concerning unfavorable consequences of commonly used psychotropic drugs. The present research was planned to assess and determine the effects of haloperidol and clozapine on testosterone, cortisol, and corticosterone levels and also their influence on androgen-dependent organs in adult male Wistar rats.

Materials And Methods: Animals were casually distributed into three groups ( = 10 in each group). Read More

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http://dx.doi.org/10.4103/ijp.IJP_145_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759527PMC

Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3β/β-catenin signaling pathway in the SH-SY5Y cell line.

Chem Biol Interact 2019 Dec 26;314:108823. Epub 2019 Sep 26.

Department of Pharmacology, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey. Electronic address:

Schizophrenia cannot be treated sufficiently with existing antipsychotic drugs. Taken into account that increased Glycogen Synthase Kinase 3 Beta (GSK-3β) activity is associated with schizophrenia pathophysiology and certain antipsychotics can be able to decrease GSK3β activity, inhibition of GSK-3β activity could be a novel approach for the treatment of schizophrenia. In the present study MK-801, a widely used chemical for the in vivo/in vitro modeling of schizophrenia was selected to evoke a detrimental effect on cellular survival via GSK3β and related proteins. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.108823DOI Listing
December 2019
3 Reads

The comet assay applied to HepG2 liver spheroids.

Mutat Res 2019 09 29;845:403033. Epub 2019 Mar 29.

Fraunhofer Institute for Biomedical Engineering IBMT, Department Bioprocessing & Bioanalytics, Joseph-von-Fraunhofer-Weg 1, 66280 Sulzbach, Germany. Electronic address:

In accordance with the 3 Rs to reduce in vivo testing, more advanced in vitro models, moving from 2D monolayer to 3D cultures, should be developed for prediction of human toxicity of industrial chemicals and environmental pollutants. In this study we compared cytotoxic and genotoxic responses induced by chemicals in 2D and 3D spheroidal cultures of the human liver cancer cell line HepG2. HepG2 spheroids were prepared by hanging drop technology. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.03.006DOI Listing
September 2019
1 Read

A UPLC-MS/MS Assay for Simultaneous Determination of Two Antipsychotics and Two Antidepressants in Human Plasma and Its Application in Clinic.

Curr Pharm Biotechnol 2020 ;21(1):60-69

Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Antidepressants and antipsychotics are widely prescribed drugs for the treatment of mental diseases. Therapeutic drug monitoring (TDM) is recommended for patients taking these drugs to ensure pharmaceutical efficacy, medication compliance and prevent toxicity.

Objective: An ultra-high performance liquid chromatography/tandem-mass spectrometry (UPLC-MS/ MS) method was developed for simultaneous determination of two Antidepressants-Fluoxetine (FLU) and Escitalopram (ESC), and two antipsychotics-risperidone (RIS) and aripiprazole (ARI), in human plasma. Read More

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http://dx.doi.org/10.2174/1389201020666190830150549DOI Listing
March 2020
1 Read

CYTOTOXIC EFFECTS OF ARIPIPRAZOLE ON MKN45 AND NIH3T3 CELL LINES AND GENOTOXIC EFFECTS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES.

Arq Gastroenterol 2019 Aug 13;56(2):155-159. Epub 2019 Aug 13.

Sana Institute of Higher Education, Sari, Iran.

Background: Gastric cancer is known as the fourth most common cancer. Current treatments for cancer have damaged the sensitive tissues of the healthy body, and in many cases, cancer will be recurrent. Therefore, need for treatments that are more effective is well felt. Read More

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http://dx.doi.org/10.1590/S0004-2803.201900000-31DOI Listing
August 2019
1 Read

Paw-Print Analysis of Contrast-Enhanced Recordings (PrAnCER): A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits.

J Vis Exp 2019 08 12(150). Epub 2019 Aug 12.

Cognitive, Linguistic & Psychological Sciences, Brown University; Department of Neuroscience, Brown University;

Gait analysis is used to quantify changes in motor function in many rodent models of disease. Despite the importance of assessing gait and motor function in many areas of research, the available commercial options have several limitations such as high cost and lack of accessible, open code. To address these issues, we developed PrAnCER, Paw-Print Analysis of Contrast-Enhanced Recordings, for automated quantification of gait. Read More

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http://dx.doi.org/10.3791/59596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827337PMC
August 2019
1 Read

Methamphetamine-associated psychosis: Clinical presentation, biological basis, and treatment options.

Hum Psychopharmacol 2019 09 22;34(5):e2710. Epub 2019 Aug 22.

UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, Massachusetts.

Introduction: Methamphetamine associated psychosis (MAP) represents a mental disorder induced by chronic methamphetamine use in a subset of users. The prevalence of the disorder has increased in several countries in Europe and Asia where methamphetamine use has increased. MAP remains difficult to distinguish from primary psychiatric disorders, especially schizophrenia, creating complications in prescribing treatment plans to patients. Read More

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http://dx.doi.org/10.1002/hup.2710DOI Listing
September 2019
5 Reads

Up-regulation of hepatic fatty acid transporters and inhibition/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis.

Toxicol Lett 2019 Nov 19;316:183-193. Epub 2019 Aug 19.

Institute of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Olanzapine, a representative of antipsychotics, is a first-line drug for treatment of schizophrenia. However, olanzapine-induced liver steatosis limits its clinical utilization. This study is to explore the mechanism of liver steatosis induced by olanzapine based on the regulation of transporters involved in uptake and oxidation of fatty acids. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.08.013DOI Listing
November 2019
6 Reads

Implementation of an in vitro methodology for phototoxicity evaluation in a human keratinocyte cell line.

Toxicol In Vitro 2019 Dec 2;61:104618. Epub 2019 Aug 2.

UCIBIO, REQUIMTE, Medtech Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Portugal.

To assess photoxicity, several in vitro methods using different cellular models have been developed for preclinical testing. Over prediction of the in vivo photosafety hazard has been however appointed. Herein, we describe the implementation and validation of an in vitro methodology for phototoxicity evaluation based on the 3T3 neutral red uptake phototoxicity test using the HaCaT human keratinocyte cell line, and UVA/UVB radiation. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.104618DOI Listing
December 2019

The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine-a histological and biochemical study in albino rats.

Cell Tissue Res 2019 Nov 24;378(2):371-383. Epub 2019 Jul 24.

Division of Medical Sciences & Graduate Entry Medicine, Royal Derby Hospital, School of Medicine, University of Nottingham, Uttoxeter Road, Derby, DE22 3DT, UK.

Oxidative stress has been implicated in reproductive toxicity induced by antipsychotics (APs). This study aims to further investigate the role of AP-induced oxidative stress in reproductive dysfunction. Thirty adult female albino rats were divided into three groups including a control group (n = 10) receiving distilled water, HAL group (n = 10) receiving haloperidol (HAL) (2 mg/kg/day), and CLZ group (n = 10) receiving clozapine (CLZ) (20 mg/kg/day). Read More

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http://dx.doi.org/10.1007/s00441-019-03067-xDOI Listing
November 2019
4 Reads
3.565 Impact Factor

Ondansetron enhanced diclofenac-induced nephrotoxicity in mice.

J Biochem Mol Toxicol 2019 Sep 23;33(9):e22378. Epub 2019 Jul 23.

Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

This study was performed to investigate the effect of ondansetron, a serotonin receptor (5-HT3) antagonist, in the alleviation of diclofenac-induced kidney injuries. NMRI mice were randomly divided into six groups and treated with (A) untreated control group, (B) diclofenac (100 mg/kg), (C) ondansetron (1 mg/kg), (D to F) ondansetron (0.1, 0. Read More

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http://dx.doi.org/10.1002/jbt.22378DOI Listing
September 2019
1.925 Impact Factor

Liraglutide toxicity presenting to the emergency department: A case report and literature review.

Emerg Med Australas 2019 10 15;31(5):895-896. Epub 2019 Jul 15.

Victorian Poisons Information Centre, Austin Toxicology Unit and Emergency Department, Austin Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/1742-6723.13343DOI Listing
October 2019
1 Read

Aripiprazole Toxicity With a Biphasic Course of Somnolence.

Pediatr Emerg Care 2019 Aug;35(8):e145-e146

From the Department of Pediatrics, Penn State Hershey Medical Center, Hershey, PA.

Introduction: Aripiprazole is an atypical antipsychotic with partial agonism at dopamine and serotonin receptors. In pediatrics, it is approved to treat irritability associated with autistic disorder along with other neuropsychological conditions. Compared with other atypical antipsychotics, it has a favorable side effect profile, but overdose experience is limited. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001889DOI Listing
August 2019
6 Reads

Persistent and transgenerational effects of risperidone in zebrafish.

Environ Sci Pollut Res Int 2019 Sep 8;26(25):26293-26303. Epub 2019 Jul 8.

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.

Since behavior is the connection between the internal physiological processes of an animal and its interaction with the environment, a complete behavioral repertoire is crucial for fish survival and fitness, at both the individual and population levels. Thus, unintended exposure of non-target organisms to antipsychotic residues in the environment can impact their normal behavior, and some of these behavioral changes can be seen during the entire life of the animal and passed to subsequent generations. Although there are some reports related to transgenerational toxicology, little is known of the long-term consequences of exposure to pharmaceutical compounds such as risperidone. Read More

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http://dx.doi.org/10.1007/s11356-019-05890-9DOI Listing
September 2019

Evaluation of Teratogenic Activity of Antiepileptic Drug Lamotrigine in Mouse Fetuses.

Folia Med (Plovdiv) 2019 Mar;61(1):84-89

Department of Anatomy, Shahrekord Faculty of Medicine, University of Medical Sciences, Shahrekord, Iran.

Background: Use of antiepileptic drugs during pregnancy can be associated with an increased risk of teratogenicity as well as congenital abnormalities. However, there are numerous discrepancies to determine whether lamotrigine, as an antiepileptic drug, can significantly induce malformation in newborn infants or not. Thus, the purpose of the study was to evaluate the teratogenic effects of lamotrigine on mouse fetuses. Read More

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http://dx.doi.org/10.2478/folmed-2018-0058DOI Listing
March 2019
6 Reads

Clozapine-induced pericarditis: an ethical dilemma.

BMJ Case Rep 2019 Jun 20;12(6). Epub 2019 Jun 20.

Oxford Health NHS Foundation Trust, Oxford, UK.

Clozapine is an atypical antipsychotic used most frequently in the management of treatment-resistant schizophrenia, where severely unwell patients have failed to respond to standard antipsychotic therapy. Clozapine is associated with a number of risks, such as agranulocytosis and long-term cardiometabolic morbidity. Reported less frequently is the risk of severe cardiac complications. Read More

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http://dx.doi.org/10.1136/bcr-2019-229872DOI Listing
June 2019
26 Reads

Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.

Toxicol Lett 2019 Oct 18;313:77-90. Epub 2019 Jun 18.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Public Security Bureau, Shanghai 200083, China. Electronic address:

Quetiapine is a common atypical antipsychotic used to treat mental disorders such as schizophrenia, bipolar disorder, and major depressive disorder. There has been increasing number of reports describing its cardiotoxicity. However, the molecular mechanisms underlying quetiapine-induced myocardial injury remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.06.005DOI Listing
October 2019
5 Reads

Haloperidol-Induced Preclinical Tardive Dyskinesia Model in Rats.

Curr Protoc Neurosci 2019 06;88(1):e68

Faculty of Nursing, State University of Rio Grande do Norte (UERN), Mossoró, Rio Grande do Norte, Brazil.

Haloperidol is a first-generation antipsychotic used in the treatment of psychoses, especially schizophrenia. This drug acts by blocking dopamine D2 receptors, reducing psychotic symptoms. Notwithstanding its benefits, haloperidol also produces undesirable impacts, in particular extrapyramidal effects such as tardive dyskinesia (TD), which limit the use of this and related drugs. Read More

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http://dx.doi.org/10.1002/cpns.68DOI Listing
June 2019
17 Reads

Multitarget-directed cotreatment with cilostazol and aripiprazole for augmented neuroprotection against oxidative stress-induced toxicity in HT22 mouse hippocampal cells.

Eur J Pharmacol 2019 Aug 13;857:172454. Epub 2019 Jun 13.

Department of Pharmacology, School of Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea; Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea. Electronic address:

Cerebrovascular dysfunction is crucially associated with cognitive impairment and a high prevalence of psychotic symptoms in the vascular dementia characterized by oxidative stress and multifactorial neurodegeneration. In this study, the significant decrease in BDNF expression in HT22 cells due to HO (0.25 mM) was little affected by either aripiprazole (1 μM) or cilostazol (1 μM) alone, but significantly increased by cotreatment with both drugs. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.172454DOI Listing
August 2019
13 Reads

The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice.

Neurotox Res 2019 Aug 14;36(2):376-386. Epub 2019 Jun 14.

Wuhan Institutes of Biomedical Sciences, Jianghan University, Triangle Lake Road No.8, Wuhan, 430056, China.

Repeated methamphetamine (METH) exposure can cause severe neurotoxicity to the central nervous system, and lead to memory deficits. L-Stepholidine (L-SPD) is a structurally identified alkaloid extract of the Chinese herb Stephania intermedia, which elicits dopamine (DA) D1-type receptors partial agonistic activity and D2-type receptors antagonistic activity. In this study, we investigated the effect of L-SPD on METH-induced memory deficits in mice and its underlying mechanisms. Read More

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http://dx.doi.org/10.1007/s12640-019-00069-zDOI Listing
August 2019
1 Read

The effect of anti-emetic drugs on rat embryonic heart activity.

Reprod Toxicol 2019 08 11;87:140-145. Epub 2019 Jun 11.

Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult human and the human and rat embryo. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.06.002DOI Listing
August 2019
4 Reads

Thioridazine Sensitizes Cisplatin Against Chemoresistant Human Lung and Ovary Cancer Cells.

DNA Cell Biol 2019 Jul 12;38(7):718-724. Epub 2019 Jun 12.

1 Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Human lung cancer cell lines A549 and A549/DDP, and ovarian cancer cell lines SKOV3 and SKOV3/DDP were subjected to thioridazine (Thio), cisplatin, or the combination; A549/DDP and SKOV3/DDP were the cisplatin-resistant sublines. Cell viability, apoptosis, and cell cycle were detected; the mitochondrial membrane potential and proteins related to mitochondrial apoptosis were determined. Thio induced cell death, and the combination of Thio and cisplatin led to the highest percentage of dead cells in four cells lines. Read More

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http://dx.doi.org/10.1089/dna.2019.4715DOI Listing
July 2019
11 Reads

Preventative effects of aripiprazole and quetiapine on seizure and lethality in a mice cocaine toxicity model: an experimental study.

J Int Med Res 2019 Aug 12;47(8):3831-3840. Epub 2019 Jun 12.

1 Department of Emergency Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

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http://dx.doi.org/10.1177/0300060519854631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726820PMC
August 2019
16 Reads

Reversal of MK-801-Induced Disruptions in Social Interactions and Working Memory with Simultaneous Administration of LY487379 and VU152100 in Mice.

Int J Mol Sci 2019 Jun 6;20(11). Epub 2019 Jun 6.

Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.

Negative and cognitive symptoms of schizophrenia contribute to an impaired social and professional life for schizophrenic patients, and in most cases, these symptoms are treatment resistant. Therefore, identification of new treatment strategies is sorely needed. Metabotropic glutamate receptors (mGlu) and muscarinic (M) receptors for acetylcholine have been considered promising targets for novel antipsychotics. Read More

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http://dx.doi.org/10.3390/ijms20112781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600181PMC
June 2019
2 Reads

Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.

Circ Res 2019 08 3;125(4):449-466. Epub 2019 Jun 3.

From the Pulmonary Hypertension Research Group of the Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Laval University, Québec City, Canada (B.R., V.N., A.B., S.P., E.T., J.O., N.C., R.A-A., L.T., A.D., S.B.-B., P.P., R.P., O.B., S.B., F.P.).

Rationale: Pulmonary hypertension (PH) due to left heart disease (LHD), or group 2 PH, is the most prevalent form of PH worldwide. PH due to LHD is often associated with metabolic syndrome (MetS). In 12% to 13% of cases, patients with PH due to LHD display vascular remodeling of pulmonary arteries (PAs) associated with poor prognosis. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314555DOI Listing
August 2019
32 Reads

Increased Antiseizure Effectiveness with Tiagabine Combined with Sodium Channel Antagonists in Mice Exposed to Hyperbaric Oxygen.

Neurotox Res 2019 Nov 30;36(4):788-795. Epub 2019 May 30.

Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Hyperbaric oxygen (HBO) is acutely toxic to the central nervous system, culminating in EEG spikes and tonic-clonic convulsions. GABA enhancers and sodium channel antagonists improve seizure latencies in HBO when administered individually, while combining antiepileptic drugs from different functional classes can provide greater seizure latency. We examined the combined effectiveness of GABA enhancers (tiagabine and gabapentin) with sodium channel antagonists (carbamazepine and lamotrigine) in delaying HBO-induced seizures. Read More

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http://dx.doi.org/10.1007/s12640-019-00063-5DOI Listing
November 2019
23 Reads

Evidence over dogma and anecdotes.

Am J Emerg Med 2019 12 16;37(12):2257. Epub 2019 May 16.

Department of Emergency Medicine, McGill University Health Centre, Montréal, Québec, Canada; Centre Antipoison Du Québec, Montréal, Québec, Canada; Département d'urgence, Hôpital Charles-Lemoyne, Greenfield Park, QC, Canada.

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http://dx.doi.org/10.1016/j.ajem.2019.05.014DOI Listing
December 2019
12 Reads

Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio).

Comp Biochem Physiol C Toxicol Pharmacol 2019 Sep 22;223:115-123. Epub 2019 May 22.

The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, PR China; School of Mental Health, Wenzhou Medical University, Wenzhou 32500, Zhejiang Province, PR China. Electronic address:

Reserpine is widely used for treatment of hypertension and schizophrenia. As a specific inhibitor of monoamine transporters, reserpine is known to deplete monoamine neurotransmitters and cause decreased movement symptoms. However, how zebrafish larvae respond to reserpine treatment is not well studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15320456193001
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http://dx.doi.org/10.1016/j.cbpc.2019.05.008DOI Listing
September 2019
19 Reads

Management of lamotrigine overdose using hemodialysis.

Am J Emerg Med 2019 08 15;37(8):1603.e1-1603.e2. Epub 2019 May 15.

Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, USA.

Lamotrigine [LTG] is primarily an anti-epileptic drug used to treat seizure disorders, depression, and bipolar disease. It is generally well tolerated with limited side effects reported during routine use. Adverse events after overdose include neurotoxicity in the form of sedation and seizure activity, as well as cardiopulmonary toxicity in the form of sodium-channel blockade and cardiovascular collapse. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.05.026DOI Listing
August 2019
3 Reads

Delayed complications after severe clozapine intoxication: a case report. The pharmacokinetic profile of clozapine and it's important role in the course of symptoms.

Int Clin Psychopharmacol 2019 09;34(5):269-272

Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), Radboud University.

Clozapine intoxications have a varied clinical presentation and may have severe complications. Management and treatment guidelines rarely highlight the risks of delayed clinical presentations. We present the case of a 50-year-old man showing severe complications 15 hours after intoxication with 4200 mg clozapine. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000272DOI Listing
September 2019
2 Reads

Another dogma dispelled? Antipsychotic treatment of sympathomimetic toxicity.

Am J Emerg Med 2019 12 6;37(12):2256-2257. Epub 2019 May 6.

Department of Emergency Medicine, University of California Davis Medical Center, Sacramento, CA, United States of America.

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http://dx.doi.org/10.1016/j.ajem.2019.05.013DOI Listing
December 2019
17 Reads

Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/NFkB mediated downstream signaling.

Biochem Pharmacol 2019 08 7;166:56-69. Epub 2019 May 7.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India. Electronic address:

Fibromyalgia (FM) is a chronic pain syndrome involving complex interplay of biogenic amines and NMDA receptor mediated hypersensitization of nociceptive pathways. Clinical management of FM is poorly addressed with only a few available therapeutic options. Coumarins are active phenolic molecules of natural origin found to have broad pharmacological activities. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.05.012DOI Listing
August 2019
2 Reads

Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal.

J Glob Oncol 2019 04;5:1-6

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.

Purpose: The purpose of the study was to compare efficacy and toxicity of olanzapine (OLN; a higher-cost drug) and haloperidol (HAL; a lower-cost drug) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC).

Patients And Methods: In a randomized, phase II trial, patients were randomly assigned to receive either OLN 10 mg orally on days 1 to 4 or HAL 1 mg orally on day 1 and 0.5 mg twice daily on days 2 to 4. Read More

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http://dx.doi.org/10.1200/JGO.18.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528728PMC
April 2019
3 Reads

Metabolomics profiling of haloperidol and validation of thromboxane-related signaling in the early development of zebrafish.

Biochem Biophys Res Commun 2019 06 10;513(3):608-615. Epub 2019 Apr 10.

Department of Chemistry, Chinese Culture University, Taipei, 11114, Taiwan. Electronic address:

Haloperidol is a common butyrophenone-derivative antipsychotic drug that is used clinically to treat schizophrenia and to control Tourette disorder. Haloperidol has been shown to be an embryonic toxicant and to cause a variety of adverse effects that affect human embryonic development. However, the pathway impaired by haloperidol during the developmental stages remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.003DOI Listing
June 2019
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Microporous polymer based on the new compound "bi-(4-vinyl phenylquinoline) amide" for enrichment and quantitative determination of lamotrigine in rat and human serum.

Anal Bioanal Chem 2019 Jun 8;411(15):3353-3360. Epub 2019 Apr 8.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Lamotrigine is one of the most widely used antiepileptic drugs in the treatment of epilepsy. This kind of drug needs to be used in the long term and should be quantitatively detected in the blood of patients to avoid drug toxicity caused by individual differences and environmental and pathological changes in the process of taking. The detection of antiepileptic drugs in human blood is challenging because of their low contents and the interference of complex matrices. Read More

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http://dx.doi.org/10.1007/s00216-019-01812-3DOI Listing
June 2019
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[Analysis of risk factors, etiology and treatment standard of lithium poisoning].

Nervenarzt 2020 Jan;91(1):57-63

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

Despite unlimited access to therapeutic drug monitoring lithium poisoning is still a common and potentially life-threatening but in most cases preventable complication of lithium treatment; however, it is still considered to be the gold standard in the treatment of affective disorders. The necessity of drug monitoring and potential lithium toxicity substantiate the skepticism of many therapists with respect to this often very effective treatment. This therefore limits the use of lithium although the unique therapeutic effects and high efficiency are well known. Read More

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http://dx.doi.org/10.1007/s00115-019-0705-7DOI Listing
January 2020
8 Reads

Clozapine-Associated Kidney Injury Complicated by Lithium Toxicity: A Case Report and Literature Review.

Authors:
Benjamin DeLucia

J Clin Psychopharmacol 2019 May/Jun;39(3):273-275

Department of Psychiatry, State University of New York at Stony Brook, Stony Brook, NY

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http://dx.doi.org/10.1097/JCP.0000000000001042DOI Listing
August 2019
8 Reads