21 results match your criteria Toxicity Mushroom - Orellanine

  • Page 1 of 1

Evaluation of orellanine-induced toxicity from the mushroom Cortinarius orellanus and the antagonistic effect of Petroselinum crispum.

Toxicon 2022 Jul 30;214:1-7. Epub 2022 Apr 30.

Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, 21163, Jordan.

Mushroom poisoning is a worldwide public health problem that may cause serious toxic consequences on renal functions. The study aimed to evaluate the acute toxicity (24 h) of orellanine (OR) from Cortinarius orellanus in rat kidney and the ameliorative effect of parsley ethanolic extract. Twelve adult male Wistar rats were used to determine intraperitoneal (ip) median lethal dose (LD) of OR, and 32 rats were divided into 4 groups (n = 8): OR group had 500 mg OR per kg bwt; OR + parsley group had the same dose of OR and after 1 h had 500 mg/kg parsley orally; parsley group had parsley only; and control had the vehicle 0. Read More

View Article and Full-Text PDF

Determination of Orellanine in Human Biological Matrices Using Liquid Chromatography with High-Resolution Mass Spectrometry Detection: A Validated Method Applied to Suspected Poisoning Cases.

J Anal Toxicol 2022 Mar 16. Epub 2022 Mar 16.

Laboratory LAT LUMTOX, 07800 La Voulte sur Rhône, France.

Consumption of mushrooms can become unsafe for the consumer in case of confusion. It is the case of some fungi of the Cortinarius genus, which contain the nephrotoxic mycotoxin orellanine responsible for their toxicity. Related case poisoning diagnosis is a challenge for both clinicians and analysts because of a long latency period between intake and toxic syndrome, the lack of available information in literature and the numerous pitfalls of orellanine identification/quantification in biological samples. Read More

View Article and Full-Text PDF

Improved Tissue-Based Analytical Test Methods for Orellanine, a Biomarker of Cortinarius Mushroom Intoxication.

Toxins (Basel) 2016 05 21;8(5). Epub 2016 May 21.

Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

Orellanine (OR) toxin is produced by mushrooms of the genus Cortinarius which grow in North America and in Europe. OR poisoning is characterized by severe oliguric acute renal failure, with a mortality rate of 10%-30%. Diagnosis of OR poisoning currently hinges on a history of ingestion of Cortinarius mushrooms and histopathology of renal biopsies. Read More

View Article and Full-Text PDF

Human and experimental toxicology of orellanine.

Hum Exp Toxicol 2016 Sep 9;35(9):1016-29. Epub 2015 Nov 9.

UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Orellanine is a nephrotoxic toxin produced by some mushroom species of the Cortinarius genus, typically found in Europe and North America. The nephrotoxicity of Cortinarius orellanus is well known and was first recognized in the 1950s when this mushroom was identified as the cause of a mass poisoning in Poland. Typically, onset of symptoms is delayed for 1-2 weeks after ingestion. Read More

View Article and Full-Text PDF
September 2016

Analysis of the mushroom nephrotoxin orellanine and its glucosides.

J Nat Prod 2012 Oct 9;75(10):1690-6. Epub 2012 Oct 9.

National Food Agency , Box 622, SE-75126 Uppsala, Sweden.

Orellanine is a nephrotoxin found in various Cortinaceae mushroom species. Unintentional consumption after these species were confused with edible mushrooms such as Cantharellus tubaeformis has caused several casualties. In this work, a quantitative HPLC-ESI-MS/MS method for total orellanine in Cortinarius rubellus, spiked blood plasma, and a mushroom stew prepared from C. Read More

View Article and Full-Text PDF
October 2012

The fungal nephrotoxin orellanine simultaneously increases oxidative stress and down-regulates cellular defenses.

Free Radic Biol Med 2008 Apr 31;44(8):1562-9. Epub 2008 Jan 31.

The Renal Center, Department of Nephrology, University of Göteborg, SE 405 30 Göteborg, Sweden.

Confusion of various nephrotoxic Cortinarius species with edible mushrooms occurs every year throughout Europe and North America. The toxin, orellanine (OR), accumulates selectively in renal tubular epithelium with ensuing renal failure after several days as the only clinical manifestation. This study was performed to clarify the mechanisms behind the kidney damage. Read More

View Article and Full-Text PDF

Cytotoxic fungi--an overview.

Toxicon 2003 Sep;42(4):339-49

Swedish Poisons Information Centre, Karolinska Sjukhuset, Stockholm S-171 76, Sweden.

Among fungal toxins causing organ damage in the human body, amatoxins and orellanine remain exceptional. Amatoxins, a group of bicyclic octapeptides occurring in some Amanita, Galerina and Lepiota species, induce deficient protein synthesis resulting in cell death, but might also exert toxicity through inducing apoptosis. Target organs are intestinal mucosa, liver and kidneys. Read More

View Article and Full-Text PDF
September 2003

Peroxidase-mediated oxidation, a possible pathway for activation of the fungal nephrotoxin orellanine and related compounds. ESR and spin-trapping studies.

Free Radic Res 1998 May;28(5):497-505

Groupe GEDEXE, UFR de Pharmacie, Université J. Fourier de Grenoble, Meylan, France.

Orellanine is the tetrahydroxylated and di-N-oxidized bipyridine toxin extracted from several Cortinarius mushrooms among them C. orellanus. The pathogenic mechanism involved in the C. Read More

View Article and Full-Text PDF

Generation of oxygen radicals from iron complex of orellanine, a mushroom nephrotoxin; preliminary ESR and spin-trapping studies.

Free Radic Res 1998 Jan;28(1):45-58

Groupe GEDEXE, UFR de Pharmacie de Grenoble, La Tronche, France.

Orellanine, [2,2'-bipyridine]-3,3',4,4'-tetrol-1,1'-dioxide, is the toxin responsible for the lethal nephrotoxicity of some Cortinarius mushrooms. Our present ESR and spin-trapping studies of the redox properties of the system of non-illuminated orellanine, ferrous iron and dioxygen contribute to understanding the molecular mechanism of its toxicity. UV-visible spectrophotometry, cyclic voltammetry and ESR in frozen medium showed the formation of a wine-red tris complex, Fe(III)Or3. Read More

View Article and Full-Text PDF
January 1998

First electron spin resonance evidence for the production of semiquinone and oxygen free radicals from orellanine, a mushroom nephrotoxin.

Free Radic Biol Med 1995 Oct;19(4):417-29

Groupe GEDEXE, UFR de Pharmacie, Université J. Fourier de Grenoble, Meylan, France.

Orellanine is the tetrahydroxylated and di-N-oxidized bipyridine toxin from several Cortinarius mushrooms. The mechanism responsible for its lethal nephrotoxicity was unknown until now. Our present ESR spectroscopic study of the redox properties of the toxin is an original contribution to the knowledge of its toxicity. Read More

View Article and Full-Text PDF
October 1995

Cortinarins in Cortinarius speciosissimus? A critical revision.

Experientia 1991 Jun;47(6):634-40

Institut für Organische Chemie der Georg-August-Universität Göttingen, Germany.

Fluorescent cyclic decapeptides, the so-called cortinarins, have been claimed to cause the toxicity of the deadly poisonous mushroom Cortinarius speciosissimus. As the structure elucidation described in the literature is doubtful in decisive parts, the proposed structures must be disputed. The present study demonstrates that the fluorescence is mainly due to ergosta-4,6,8(14),22-tetraen-3-one (8) and to photodecomposition products of the nephrotoxin orellanine (1). Read More

View Article and Full-Text PDF

Orellanine inhibits protein synthesis in Madin-Darby canine kidney cells, in rat liver mitochondria, and in vitro: indication for its activation prior to in vitro inhibition.

Toxicology 1991 Mar;67(1):53-62

Unité de Formation et de Recherche de Pharmacie, Université J. Fourier, Grenoble, Meylan.

Pure orellanine, a nephrotoxic compound extracted from the mushroom Cortinarius orellanus, which is known to induce severe kidney damage several days or weeks after ingestion, is found to inhibit strongly the synthesis of macromolecules (proteins, RNA and DNA) in Madin-Darby canine kidney (MDCK) cells and in rat liver mitochondria, although the uptake of labelled precursors of the above macromolecules is not significantly altered. Direct addition of orellanine to a cell-free system of rabbit reticulocyte lysate does not produce any inhibition of protein synthesis. However, when orellanine is pre-incubated with activating rat liver microsomal systems, this inhibition occurs. Read More

View Article and Full-Text PDF

[QSAR analysis of the toxicity of a series of pyridines related to the mushroom toxin orellanine: comparison of the results obtained with physico-chemical, steric and quantal parameters].

Pharmazie 1990 Oct;45(10):771-4

U.F.R. de Pharmacie Université J. Fourier de Grenoble France.

To complete a preceding work, we have made a QSAR study of a series of mono- or bi-pyridines, aminoxidized or not, wearing diverse substituents and related to the mushroom toxin orellanine. For the description of these molecules, we tried several sterical parameters which we have recently defined (sigma D and sigma S) or which we define here (D3) as well as physical and quantal parameters calculated with the CNDO/2 method, besides the parameter of hydrophobicity log P. Among the regression equations obtained, three have a correlation coefficient greater than 0. Read More

View Article and Full-Text PDF
October 1990

Toxic properties of the mushroom Cortinarius orellanus (Fries). II. Impairment of renal function in rats.

Authors:
H Prast W Pfaller

Arch Toxicol 1988 Aug;62(1):89-96

Institute of Pharmacodynamics and Toxicology, University of Innsbruck, Austria.

Oral administration of the toxic mushroom Cortinarius orellanus (Fr.) to male Sprague Dawley rats caused serious impairment of renal function. The signs observed were similar to those produced in humans who ingest this fungus. Read More

View Article and Full-Text PDF

Toxic properties of the mushroom Cortinarius orellanus. I. Chemical characterization of the main toxin of Cortinarius orellanus (Fries) and Cortinarius speciosissimus (Kühn & Romagn) and acute toxicity in mice.

Arch Toxicol 1988 Aug;62(1):81-8

Institute of Pharmacodynamics and Toxicology, University of Innsbruck, Austria.

The toxins of the mushrooms Cortinarius orellanus (Fries) and Cortinarius speciosissimus (Kühn & Romagn) were isolated by extraction procedures and Sephadex chromatography. All intermediate and end products of the purification process were tested in mice for acute toxicity after oral and i.p. Read More

View Article and Full-Text PDF

Nephrotoxicity of orellanine, a toxin from the mushroom Cortinarius orellanus.

Arch Toxicol 1988 ;62(2-3):242-5

Laboratoire de Chimie et Toxicologie, U.F.R. de Pharmacie, Université J. Fourier, Grenoble, France.

Pure orellanine extracted from the mushroom Cortinarius orellanus is highly toxic in mice both when given intraperitoneally (LD50 = 12.5 mg/kg) or per os (LD50 = 90 mg/kg). The kidneys of mice injected i. Read More

View Article and Full-Text PDF
December 1988

Phytotoxicity of orellanine, a mushroom toxin.

Toxicon 1987 ;25(3):350-4

Orellanine, a toxic principle of Cortinarius orellanus Fr., efficiently inhibited the photosynthetic activity of duckweed, Lemna minor L., at a concentration of 0. Read More

View Article and Full-Text PDF

Isolation and nephrotoxic studies of orellanine from the mushroom Cortinarius speciosissimus.

Toxicon 1987 ;25(2):195-9

A nephrotoxic substance has been isolated from Cortinarius speciosissimus. The 1H-NMR and 13C-NMR mass spectra indicated the chemical structure to be 3,3',4,4'-tetrahydroxy-2,2'-bipyridine-N-N'-dioxide. The toxin was quantitated using reversed phase high performance liquid chromatography (HPLC) with electrochemical detection. Read More

View Article and Full-Text PDF

A quantitative structure-activity relationship study on substituted pyridines as a contribution to the knowledge of the toxic effects of orellanine, a toxin from the mushroom Cortinarius orellanus.

Toxicon 1985 ;23(5):815-24

Quantitative structure-activity relationships are established based upon the toxicity of 21 substituted pyridines. They are used as a predictive tool to calculate the toxicity of orellanine, a toxin from the mushroom Cortinarius orellanus (Fries). The actual toxicity of orellanine is quite different from the values calculated based upon the postulated bipyridine structure. Read More

View Article and Full-Text PDF
February 1986

Mushroom poisoning caused by species of the genus Cortinarius Fries.

Arch Toxicol 1983 Jun;53(2):87-106

Symptomatology, clinical characteristics and pathogenesis of mushroom poisoning caused by Cortinarius species are surveyed. The isolation of a bipyridine--orellanine--from Cortinarius orellanus is held to be responsible for the nephrotoxicity of this species as well as the closely related C. speciosissimus. Read More

View Article and Full-Text PDF
  • Page 1 of 1