657,277 results match your criteria Toxicity Mushroom - Disulfiramlike Toxins


[A case report on multiple organ dysfunction syndrome caused by acute carbon tetrachloride poisoning].

Authors:
N Xue Z Li Y J Yan

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):63-65

Shandong Provincial Hospital of Occupational Disease, Jinan 250062, China.

Occupational acute carbon tetrachloride poisoning occurs when a worker is exposed to highly condensed carbon tetrachloride in a short time and suffers from diseases damaging mainly his neutral system and (or) liver and kidney. This article reports a case of what clinical symptoms MODS patients show and how to diagnose, differential diagnosis and therapy process. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.015DOI Listing
January 2019

Production and characterization of extracellular polymeric substances (EPS) generated by a carbofuran degrading strain Cupriavidus sp. ISTL7.

Bioresour Technol 2019 Mar 12;282:417-424. Epub 2019 Mar 12.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India. Electronic address:

The present study demonstrates EPS production by Cupriavidus sp. ISTL7 along with its capability to remediate a toxic carbamate pesticide, carbofuran. The strain ISTL7 efficiently degraded approximately 98% of carbofuran (400 ppm) within 96 h. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.03.054DOI Listing

Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review.

Environ Toxicol Pharmacol 2019 Mar 8;68:101-108. Epub 2019 Mar 8.

Fisheries Research & Development Institute, West Sea Fisheries Research Institute, National Institute of Fisheries Science, Taean, South Korea. Electronic address:

Lead (Pb) is a highly toxic metal in aquatic environments. Fish are at the top of the food chain in most aquatic environments, and are the most susceptible to the toxic effects of Pb exposure. In addition, fish are one of the most abundant vertebrates, and they can directly affect humans through food intake; therefore, fish can be used to assess the extent of environmental pollution in an aquatic environment. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.010DOI Listing

Nickel oxide nanoparticles cause substantial physiological, phytochemical, and molecular-level changes in Chinese cabbage seedlings.

Plant Physiol Biochem 2019 Mar 12;139:92-101. Epub 2019 Mar 12.

Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Nickel oxide nanoparticles (NiO NPs) are utilized in various industries and their release into the environment may lead to the pollution of agricultural areas. However, assessing the toxicity of NiO NPs in major food crops is difficult due to the limited information available on their toxicity. The present investigation was carried out to evaluate how NiO NPs affect plant growth, photosynthetic efficiency, and phytochemical content, as well as changes at the transcriptional level of these phytochemicals in Chinese cabbage seedlings. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.03.010DOI Listing

Growth, physiological function, and antioxidant defense system responses of Lemna minor L. to decabromodiphenyl ether (BDE-209) induced phytotoxicity.

Plant Physiol Biochem 2019 Mar 13;139:113-120. Epub 2019 Mar 13.

College of Biology and the Environment, Joint Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, PR China. Electronic address:

Polybrominated diphenyl ethers (PBDEs), represent one of the new types of persistent organic pollutants (POPs) that are currently found in ambient aquatic ecosystems. Lemna minor L. is a floating freshwater plant, which is widely employed for phytotoxicity studies of xenobiotic substances. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.03.018DOI Listing

Antifouling paint particles in intertidal estuarine sediments from southwest England and their ingestion by the harbour ragworm, Hediste diversicolor.

Environ Pollut 2019 Mar 8;249:163-170. Epub 2019 Mar 8.

Marine Ecology and Biodiversity Group, Plymouth Marine Laboratory, Prospect Place, Plymouth, PL1 3DH, UK.

Antifouling paint particles (APPs) of between 500 μm and >2 mm in diameter have been identified in silty, intertidal estuarine sediments through a combination of microscopy and x-ray fluorescence spectrometry. APPs were heterogeneously distributed, with maximal concentrations of 430 particles L (0.2 g L) near to a facility where boats are regularly maintained and 400 particles L (4. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.009DOI Listing

Comparative contributions of copper nanoparticles and ions to copper bioaccumulation and toxicity in barnacle larvae.

Environ Pollut 2019 Mar 8;249:116-124. Epub 2019 Mar 8.

Department of Ocean Science, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong; HKUST Shenzhen Research Institute, Shenzhen, 518057, China. Electronic address:

Cu nanoparticles (CuNPs) have been widely used in numerous products, and may become a potential threat to marine organisms, but their behavior in the marine environments and potential toxicity to marine organisms remain little known. In the present study, we investigated the behavior of CuNPs in seawater, as well as the toxicity and bioaccumulation of CuNPs and copper sulfate (CuSO) in barnacle larvae (Balanus amphitrite), a dominant fouling invertebrate in marine environment. CuNPs tended to aggregate in natural seawater and released Cu ion rapidly into seawater. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.103DOI Listing

Multi-targeted approach by 2-benzimidazolylquinoxalines-loaded cationic arginine liposomes against сervical cancer cells in vitro.

Colloids Surf B Biointerfaces 2019 Mar 12;178:317-328. Epub 2019 Mar 12.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan, 420088, Russian Federation.

Multi-targeted approaches for inhibition of сervical cancer cells in vitro were developed by implementing two different strategies and drug combination for creation of new therapeutic target agents and for nanotechnological-enhancement of intracellular delivery. New 2-benzimidazolylquinoxalines derivatives were synthesized and characterized by combining two different pharmacophores - benzimidazole and quinoxaline rings directly bonded in their structures. Spectrophotometric technique for determination of content of compounds in various media was developed to evaluate their solubility in water and micellar solutions of surfactants. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.021DOI Listing

Acute and sub-chronic toxicity bioassays of Olive Mill Wastewater on the Eastern mosquitofish Gambusia holbrooki.

Ecotoxicol Environ Saf 2019 Mar 15;175:48-57. Epub 2019 Mar 15.

Hellenic Centre for Marine Research, Institute of Marine Biological Resources and Inland Waters, Anavissos, 19013 Attica, Greece.

Olive oil production generates large volumes of wastewaters mostly in peri-Mediterranean countries with adverse impacts on the biota of the receiving aquatic systems. Few studies have however documented its toxicity on aquatic species, with an almost total lack of relative studies on fish. We assessed the acute and sub-chronic OMW toxicity, as well as the acute and sub-chronic behavioural, morphological and biochemical effects of OMW exposure on the mosquitofish Gambusia holbrooki. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.03.025DOI Listing

Uptake, translocation and phytotoxicity of antimonite in wheat (Triticum aestivum).

Sci Total Environ 2019 Mar 11;669:421-430. Epub 2019 Mar 11.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, PR China.

Antimony (Sb) contamination of soils and its potential negative impact on crop yields have been recently recognized. To explore the effects of Sb(III) on wheat, responses of physical growth properties, enzyme activities and gene expression were examined. The root length was the most relevant indicator to exposure concentration, the root fresh weight was the most sensitive endpoint according to the comparison of the EC (50% inhibitory effect concentration) values, and NRAMP1 gene expression at 1 mg L was more sensitive than other genes. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.145DOI Listing

Differential toxicity of the UV-filters BP-3 and BP-4 in Chlamydomonas reinhardtii: A flow cytometric approach.

Sci Total Environ 2019 Mar 9;669:412-420. Epub 2019 Mar 9.

Laboratorio de Microbiología, Facultad de Ciencias, Universidad de A Coruña, Campus de A Zapateira s/n, 15071 A Coruña, Spain.

Due to the concern about the negative effects of exposure to sunlight, UV-filters are being introduced in all kind of cosmetic formulas. Wastewater treatment plants are not able to remove and/or degrade them; consequently they find their way into rivers, lakes and oceans. These chemicals are acquiring a concerning status due to their increasingly common use and the potential risk for the environment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.116DOI Listing

Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy.

Biomacromolecules 2019 Mar 18. Epub 2019 Mar 18.

The simultaneous delivery of multiple therapeutics to a single site has shown promise for cancer targeting and treatment. However, because of the inherent differences in charge and size between drugs and biomolecules, new approaches are required for co-localization of unlike components in one delivery vehicle. In this work, we demonstrate that triblock copolymers containing click nucleic acids (CNAs) can be used to simultaneously load a prodrug enzyme (cytosine deaminase, CodA) and a chemotherapy drug (doxorubicin, DOX) in a single polymer nanoparticle. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00040DOI Listing

Aggregation Behavior of Inorganic 2D Nanomaterials Beyond Graphene: Insights from Molecular Simulations and Modified DLVO Theory.

Environ Sci Technol 2019 Mar 18. Epub 2019 Mar 18.

We report the comparative aggregation behavior of three emerging inorganic 2D nanomaterials (NMs): MoS2, WS2, and h-BN in aquatic media. Their aqueous dispersions were subjected to aggregation under varying concentrations of monovalent (NaCl) and divalent (CaCl2) electrolytes. Moreover, Suwanee River Natural Organic Matter (SRNOM) has been used to analyze the effect of natural macromolecules on 2D NM aggregation. Read More

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http://dx.doi.org/10.1021/acs.est.8b05180DOI Listing

Microneedles of Chitosan-porous carbon nanocomposites: stimuli (pH and electric field) initiated drug delivery and toxicological studies.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Department of Applied Physics, Defence Institute of Advanced Technology, Pune, India- 411025.

An array of microneedles (MNs) of Chitosan- Graphene assembled in porous carbon (CS- GAPC) nanocomposites have been synthesized and evaluated. The safety of the formulated system has been ensured using detailed in-vivo toxicological studies and efficacy has been ensured by evaluating the stimuli (pH and electric field) initiated drug delivery properties. Drug Cephalexin has been incorporated in these MNs. Read More

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http://dx.doi.org/10.1002/jbm.a.36672DOI Listing

Science-based targets for antibiotics in receiving waters from pharmaceutical manufacturing operations.

Integr Environ Assess Manag 2019 Mar 18. Epub 2019 Mar 18.

Merck & Co., Inc., Kenilworth, NJ, USA.

In 2016, the United Nations declared the need for urgent action to combat the global threat of antimicrobial resistance (AMR). In support of this effort, the pharmaceutical industry has committed to measures aimed at improving the stewardship of antibiotics both within and outside the clinic. Notably, a group of companies collaborated to specifically address concerns related to antibiotic residues being discharged from manufacturing sites. Read More

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http://dx.doi.org/10.1002/ieam.4141DOI Listing

Prenatal brain development as a target for urban air pollution.

Basic Clin Pharmacol Toxicol 2019 Mar 18. Epub 2019 Mar 18.

ISGlobal, Barcelona, Spain.

Air pollution is the main urban-related environmental hazard and one of the major contributors to the global burden of disease based on its cardio-vascular-respiratory impacts. In children, exposure to urban air pollution is associated, among others, with decelerated neurodevelopment early in life and increased risk of neurodevelopmental problems such as attention deficit-hyperactivity disorder, autism spectrum disorders, academic failure and the start of Alzheimer's pathogenesis. However, the evidence of the effects of air pollution on brain development is still inadequate, mainly due to the limitations in (i) characterizing brain development (most studies were based on subjective tools such as questionnaires or neuropsychological tests) and (ii) air pollution exposure (most studies only used residential levels based on geographical modelling and also overlooking the variation in the mixture of air pollutants as well as the composition and hence toxicity of particulate pollutants in different settings), (iii) the lack of studies during the most vulnerable stages of brain development (foetal and early life (first two years postnatally)), and (iv) the lack of structural and functional imaging data underlying these effects. Read More

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http://dx.doi.org/10.1111/bcpt.13226DOI Listing

Whole effluent toxicity data and discharge volumes to assess the likelihood that environmental risks of offshore produced water discharges are adequately controlled.

Integr Environ Assess Manag 2019 Mar 18. Epub 2019 Mar 18.

Shell International B.V., Carel van Bylandtlaan 30, Den Haag, The Netherlands.

In 2012, the Oslo-Paris Commission (OSPAR) adopted Recommendation 2012/5 for a Risk-Based Approach (RBA) to the Management of Produced Water Discharges from Offshore Installations. As part of this recommendation, OSPAR requires that the environmental risk of the discharge of produced water is characterised based on whole effluent toxicity (WET) studies and/or on a substance-based assessment. In this paper we describe an assessment of the likelihood that the environmental risk of produced water discharges is adequately controlled based on WET data for 19 oil and gas producing platforms and their discharge volumes. Read More

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http://dx.doi.org/10.1002/ieam.4139DOI Listing

Severe opioid toxicity following rupture of an ingested drug balloon in a body packer.

ANZ J Surg 2019 Mar 18. Epub 2019 Mar 18.

Department of General Surgery, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.

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http://dx.doi.org/10.1111/ans.15057DOI Listing

Disulfide-unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA.

Angew Chem Int Ed Engl 2019 Mar 18. Epub 2019 Mar 18.

Nagoya University, Department of Chemistry, Graduate School of Science, Furo, Chikusa, 464-8602, Nagoya, JAPAN.

Development of intracellular delivery methods for antisense DNA and siRNA is important. Previously reported methods using liposomes or receptor-ligands have a problem that oligonucleotides take several hours or more to reach the cytoplasm due to long-time residence of oligonucleotides at endosomes. In this study, we clarified that oligonucleotides modified with low molecular disulfide units at the terminus reaches the cytoplasm 10 minutes after the administration to cultured cells. Read More

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http://dx.doi.org/10.1002/anie.201900993DOI Listing

Pulmonary Mycobacterium abscessus complex in children with cystic fibrosis: A practical management guideline.

J Paediatr Child Health 2019 Mar 18. Epub 2019 Mar 18.

Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.

The treatment of Mycobacterium abscessus complex (MABSC) pulmonary infections is an emerging challenge in patients with cystic fibrosis (CF). Multidrug therapy for prolonged durations is required and carries the significant burden of drug-related toxicity, cost and selective pressure for multiresistant bacteria. International guidelines acknowledge that clinical and in vitro data to support treatment regimens are limited, particularly in children. Read More

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http://dx.doi.org/10.1111/jpc.14427DOI Listing

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.

Mol Carcinog 2019 Mar 18. Epub 2019 Mar 18.

Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity and the acquired resistance by cancer cells. Therefore, synthetic retinoids were developed, such as the atypical adamantyl retinoid ST1926 that provides enhanced bioavailability and reduced toxicity. Read More

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http://dx.doi.org/10.1002/mc.23004DOI Listing

THE UNEXPECTED ABSENCE OF NICKEL EFFECTS ON A DAPHNIA POPULATION AT THREE TEMPERATURES IS CORRECTLY PREDICTED BY A DYNAMIC ENERGY BUDGET INDIVIDUAL-BASED MODEL (DEB-IBM).

Environ Toxicol Chem 2019 Mar 18. Epub 2019 Mar 18.

Ghent University (UGent), Laboratory of Environmental Toxicology and Aquatic Ecology, Environmental Toxicology Unit (GhEnToxLab), Campus Coupure - Building F - 2nd floor, Coupure Links 653, Ghent, Belgium.

Recent studies have shown that temperature affects chronic Ni toxicity to Daphnia magna at the individual (apical) level. However, the effect of temperature on Ni toxicity to D. magna at population-level is unknown. Read More

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http://dx.doi.org/10.1002/etc.4407DOI Listing

Assessing Impacts of Insecticides on Different Embryonic Stages of the Non-target Aquatic Insect Cheumatopsyche brevilineata (Trichoptera: Hydropsychidae).

Authors:
Atsushi Yokoyama

Environ Toxicol Chem 2019 Mar 18. Epub 2019 Mar 18.

Institute for Agro-Environmental Sciences, National Agriculture and Food Research Organization, 3-1-3 Kannondai, Tsukuba, Ibaraki, Japan.

Although the egg of aquatic insects is one of the main life stages that can be exposed to contaminants in water, little is known about detailed impacts of contaminants on eggs of aquatic insects. This study aimed at clarifying the vulnerable embryonic stages of the caddisfly Cheumatopsyche brevilineata to two insecticides, etofenprox and diflubenzuron, which are severely harmful to aquatic insects, and at assessing the effects of exposure duration on toxicity of etofenprox to the embryonic stage. Eggs obtained from laboratory culture of the insect were exposed to etofenprox for different periods (2, 4, 6, or 8 d) and at different embryonic stages. Read More

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http://dx.doi.org/10.1002/etc.4405DOI Listing

Investigation of Surgical Adhesives for Vocal Fold Wound Closure.

Laryngoscope 2019 Mar 18. Epub 2019 Mar 18.

Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.

Objectives: Surgical adhesives are increasingly used for vocal fold microsurgery to assist wound closure and reduce the risks of scar formation. Currently used vocal fold adhesives such as fibrin glue, however, have thus far not been found to promote wound closure or reduce scarring. The objectives of this study were to investigate the mechanical strength and the cytotoxicity of three commercially available adhesives (Glubran 2, GEM, Viareggio, Italy; BioGlue, CryoLife, Kennesaw, GA; and Tisseel, Baxter Healthcare, Deerfield, IL) for vocal fold wound closure. Read More

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http://dx.doi.org/10.1002/lary.27769DOI Listing

Molecular mechanism underlying Piriformospora indica-mediated plant improvement/protection for sustainable agriculture.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):229-242

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

The beneficial endophytic microorganisms have received significant attention in agriculture because of their exceptional capabilities to facilitate functions like nutrient enrichment, water status, and stress tolerance (biotic and abiotic). This review signifies the molecular mechanisms to better understand the Piriformospora indica-mediated plants improvement or protection for sustainable agriculture. P. Read More

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http://dx.doi.org/10.1093/abbs/gmz004DOI Listing

Novel coating containing molybdenum oxide nanoparticles to reduce Staphylococcus aureus contamination on inanimate surfaces.

PLoS One 2019 18;14(3):e0213151. Epub 2019 Mar 18.

Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal.

We previously synthetized molybdenum oxide (MoO3) nanoparticles (NP) and showed their antibacterial activity against a representative collection of the most relevant bacterial species responsible for hospital-acquired infections, including Staphylococcus aureus. The aim of the present study was to prepare and characterize a novel coating with these MoO3 NP, confirm its mechanical stability, and investigate its biocidal effect to reduce S. aureus contamination on inanimate surfaces. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213151PLOS

Biomarkers of Drug-Induced Liver Toxicity.

Authors:
Manuela G Neuman

Ther Drug Monit 2019 Apr;41(2):227-234

In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Drug-induced liver injury (DILI) is a comprehensive phenomenon. The injury to the liver may occur as an unexpected and undesired reaction to a therapeutic dose of a drug (idiosyncratic reaction) or as an expected therapeutic effect of the direct (intrinsic) toxicity of a drug taken in a large enough dose to cause liver injury. The direct toxicity (type A) reactions represent an extension of the drug's therapeutic effect; they occur relatively frequently and are typically dose-related and frequency-of-exposure-related. Read More

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http://Insights.ovid.com/crossref?an=00007691-201904000-0001
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http://dx.doi.org/10.1097/FTD.0000000000000610DOI Listing
April 2019
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Biomarkers of Drug-Induced Kidney Toxicity.

Ther Drug Monit 2019 Apr;41(2):213-226

Division of Renal Diseases and Hypertension, University of Colorado at Denver, Aurora, Colorado.

Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because they are influenced by many renal and nonrenal factors independent of kidney function. A biomarker that is released directly into the blood or urine by the kidney in response to injury may be a better early marker of drug-induced kidney toxicity than blood urea nitrogen and serum creatinine. Urine albumin and urine protein, as well as urinary markers kidney injury molecule-1 (KIM-1), β2-microglobulin (B2M), cystatin C, clusterin, and trefoil factor-3 (TFF-3) have been accepted by the Food and Drug Administration and European Medicines Agency as highly sensitive and specific urinary biomarkers to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000589DOI Listing

Pharmacogenetics Biomarkers Predictive of Drug Pharmacodynamics as an Additional Tool to Therapeutic Drug Monitoring.

Ther Drug Monit 2019 Apr;41(2):121-130

CHU Limoges, Université de Limoges, Inserm, IPPRITT, U1248, F-87000 Limoges, France.

Conventional therapeutic drug monitoring refers to the individualization of drug dosage by maintaining plasma or blood drug concentrations within a targeted therapeutic range. Accordingly, an individualized dose is proposed to the clinician according to the drug plasma or blood concentration using an a posteriori approach. Pharmacogenetics (PGx) has recently emerged as an additional tool to refine dose selection or, more interestingly to select, a priori, the first dose to administer. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000591DOI Listing

Neuroinflammation in the Developing Brain: Risk Factors, Involvement of Microglial Cells, and Implication for Early Anesthesia.

Anesth Analg 2019 Apr;128(4):718-725

From the Division of Neonatology and Pediatric Intensive Care, University Hospitals Geneva, Geneva, Switzerland.

Microglia cells, the resident macrophages of the central nervous system, are key actors for specific brain functions that are critical for development and health. Microglial reactivity and functions, even when immature, play a major role if the developing brain is subjected to abnormal perinatal events. Brain exposure to general anesthesia, surgery, or analgesic drugs during early infancy may adversely affect its maturation and plasticity after injury. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004032DOI Listing

Assessing Long-term Neurodevelopmental Outcome Following General Anesthesia in Early Childhood: Challenges and Opportunities.

Anesth Analg 2019 Apr;128(4):681-694

From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.

Neurodegeneration has been reported in young animals after exposure to all commonly used general anesthetic agents. The brain may be particularly vulnerable to anesthetic toxicity during peak synaptogenesis (in gestation and infancy). Human studies of long-term neurodevelopmental outcome following general anesthesia in early childhood report contradictory findings. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004052DOI Listing

Knowledge of gastrointestinal toxicity mechanisms is paving the way for improved assessment and management of patient supportive care.

Curr Opin Support Palliat Care 2019 Mar 14. Epub 2019 Mar 14.

Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SPC.0000000000000424DOI Listing

A Conversation with Gary Lyman, MD: Biosimilars and the Search for the Cure To Cancer Treatment's Financial Toxicity.

Authors:
Peter Wehrwein

Manag Care 2019 Jan;28(1):12-15

Lyman has emerged as an important voice about biosimilars and their potential for corralling cancer costs. It's personal because Lyman is all too aware of how the price of medications can ruin patients financially. We need more biosimilars on the market, he contends. Read More

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http://dx.doi.org/DOI Listing
January 2019

Optoelectronic Properties of Ternary I-III-VI2 Semiconductor Nanocrystals: Bright Prospects with Elusive Origins.

J Phys Chem Lett 2019 Mar 18. Epub 2019 Mar 18.

Colloidal nanocrystals of ternary I-III-VI2 semiconductors are emerging as promising alternatives to Cd- and Pb-chalcogenide nanocrystals due to their inherently lower toxicity, while still offering widely tunable photoluminescence. These properties make them promising materials for a variety of applications. However, the realization of their full potential has been hindered by both their underdeveloped synthesis and the poor understanding of their optoelectronic properties, whose origins are still under intense debate. Read More

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http://dx.doi.org/10.1021/acs.jpclett.8b03653DOI Listing

Targeted lipid nanoemulsions encapsulating epigenetic drugs exhibit selective cytotoxicity on CDH1-/FOXM1+ triple negative breast cancer cells.

Mol Pharm 2019 Mar 18. Epub 2019 Mar 18.

The plasticity of cancer epigenetics makes them plausible candidates for therapeutic intervention. We took advantage of elevated expression of lysophosphatidic acid receptor 1 (LPAR1) in triple negative breast cancer (TNBC) tissues to target Decitabine (DAC) and Panobinostat (PAN) to breast cancer cells. DAC and PAN were shown to reverse abnormal methylation of DNA and altered chromatin structure, respectively, leading to increased expression of tumor suppressor genes and decreased expression of oncogenes. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01065DOI Listing

Safe and effective delivery of antitumor drug using mesenchymal stem cells impregnated with submicron carriers.

ACS Appl Mater Interfaces 2019 Mar 18. Epub 2019 Mar 18.

An important area in modern malignant tumor therapy is the optimization of the antitumor drugs pharmacokinetics. The use of some antitumor drugs is limited in clinical practice due to their high toxicity. Therefore, the strategy for optimizing the drug pharmacokinetics is focusing on the generation of high local concentrations of these drugs in the tumor area with minimal systemic and tissue-specific toxicity. Read More

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http://dx.doi.org/10.1021/acsami.8b22685DOI Listing

--Large-Ring Cyclodextrins as Chiral Selectors for Enantiomeric Pharmaceuticals.

Angew Chem Int Ed Engl 2019 Mar 18. Epub 2019 Mar 18.

Universitat Leipzig, Microbiology and Bioprocess Technology, Johannisallee 23, 04103, Leipzig, GERMANY.

Large-ring cyclodextrins (CD) are cyclic glucans composed of 9 or more α-1,4-linked glucose units. They are minor side products of bacterial glucanotransferases (CGTases, EC 2.4. Read More

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http://dx.doi.org/10.1002/anie.201900911DOI Listing

Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant.

JAMA Pediatr 2019 Mar 18:e190081. Epub 2019 Mar 18.

Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: Studies demonstrating improved survival after allogeneic hematopoietic cell transplant generally exclude infants.

Objective: To analyze overall survival trends and other outcomes among infants who undergo allogeneic hematopoietic cell transplant.

Design, Setting, And Participants: In this cohort study, we used time-trend analysis to evaluate 3 periods: 2000 through 2004, 2005 through 2009, and 2010 through 2014. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2019.0081DOI Listing

Rabbit Model of Intra-Arterial Chemotherapy Toxicity Demonstrates Retinopathy and Vasculopathy Related to Drug and Dose, Not Procedure or Approach.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):954-964

Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.

Purpose: To use our intra-arterial chemotherapy (IAC) rabbit model to assess the impact of IAC procedure, drug, dose, and choice of technique on ocular structure and function, to study the nature and etiology of IAC toxicity, and to compare to observations in patients.

Methods: Rabbits received IAC melphalan (0.4-0. Read More

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http://dx.doi.org/10.1167/iovs.18-25346DOI Listing

Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities.

Biomater Sci 2019 Mar 18. Epub 2019 Mar 18.

State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.

Microbial infections have always been serious challenges to human health considering that antibiotics almost inevitably induce microbial resistance. Therefore, it is urgent to develop a new antibacterial agent that is active against drug-resistant bacteria and is less susceptible to microbial resistance. In this work, a series of host defense peptide (HDP) mimicking antibacterial poly-β-peptides were synthesized, characterized and evaluated for their biological activities. Read More

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http://dx.doi.org/10.1039/c9bm00248kDOI Listing

Incidental finding of non-Hodgkin's lymphoma in a patient affected by castration-sensitive prostate cancer: A case report.

Medicine (Baltimore) 2019 Mar;98(11):e14805

Department of Medical Oncology, Azienda Ospedaliero-Universitaria "A. Cardarelli", Naples.

Rationale: This article describes the case of a patient with 2 simultaneous malignant diseases: Follicular lymphoma and 'castration sensitive prostate cancer. Patients with multiple cancers are not easy to manage and it is difficult to find the appropriate approach and resources to use with them. We focused our attention on how to choose the correct strategy to face 2 different neoplasms and control the adverse reactions related to the corresponding treatments. Read More

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http://dx.doi.org/10.1097/MD.0000000000014805DOI Listing

Evidence of Astragalus injection combined platinum-based chemotherapy in advanced nonsmall cell lung cancer patients: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(11):e14798

Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine.

Background: Platinum-based chemotherapy is one of the standard treatments for advanced nonsmall cell lung cancer (NSCLC). Despite on an effective treatment for advanced NSCLC patients, its high toxicity and limited clinical effects have raised big concerns. Astragalus injection (AGI) has been commonly employed as an adjutant chemotherapy drug for NSCLC in China. Read More

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http://dx.doi.org/10.1097/MD.0000000000014798DOI Listing

Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes.

Anesth Analg 2019 Mar 11. Epub 2019 Mar 11.

From the Laboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts.

Background: Capsaicin, the active component of chili peppers, can produce sensory-selective peripheral nerve blockade. Coadministration of capsaicin and tetrodotoxin, a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks. However, capsaicin can be neurotoxic, and tetrodotoxin can cause systemic toxicity. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004108DOI Listing

Effect of Intraoperative Goal-directed Balanced Crystalloid versus Colloid Administration on Major Postoperative Morbidity: A Randomized Trial.

Anesthesiology 2019 Mar 14. Epub 2019 Mar 14.

From the Department of Anesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria (B.K.) the Departments of Outcomes Research (D.I.S., A.K.) General Anesthesiology (A.K.), Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio. Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Medical University of Vienna, Vienna, Austria Ohio State University, Columbus, Ohio.

What We Already Know About This Topic: Crystalloid solutions leave the circulation quickly, whereas colloids remain for hours, thus promoting hemodynamic stability. However, colloids are expensive and promote renal toxicity in critical care patients. Whether goal-directed intraoperative tetrastarch colloid administration reduces complications or promotes renal injury remains unknown. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002601DOI Listing

Switch to rilpivirine improves diabetes in an elderly HIV-positive patient.

Infez Med 2019 Mar;27(1):103-105

Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio" Chieti-Pescara, Italy.

Glucose intolerance and diabetes are becoming increasingly common in HIV-infected patients in the cART era. Many factors are associated with the development of diabetes in HIV-infected individuals who receive cART, one of which is the assumption of specific antiretroviral classes or agents. We describe a case in a 72-year-old Caucasian man with long-term HIV infection. Read More

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Combined Toxicity of Silver Nanoparticles with Hematite or Plastic Nanoparticles to Two Freshwater Algae.

Environ Sci Technol 2019 Mar 18. Epub 2019 Mar 18.

In the natural environment, the interactions of different types of nanoparticles (NPs) may alter their toxicity, thus masking their true environmental effects. This study investigated the toxicity of silver NPs (AgNPs) combined with hematite (HemNPs) or polystyrene (PsNPs) NPs towards the freshwater algae Chlamydomonas reinhardtii and Ochromonas danica. The former has a cell wall and cannot internalize these NPs, while the latter without a cell wall can. Read More

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http://dx.doi.org/10.1021/acs.est.8b07001DOI Listing

Protective Effect of Gallic Acid on Testicular Tissue, Sperm Parameters, and DNA Fragmentation against Toxicity Induced by Cyclophosphamide in Adult NMRI Mice.

Urol J 2019 Mar 18. Epub 2019 Mar 18.

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: This study aimed to investigate the protective effect of Gallic acid (GA) on the Cyclophosphamide (CP) toxicity induced in the reproductive system.

Materials And Methods: After a pilot study for dose responses of Gallic acid ,Forty adult male NMRI mice were divided into 5 groups (n=8): control, sham (NaCl Serum: 0.2mL per day), CP (15 mg kg-1 per week; IP), GA (12. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4858DOI Listing

3D impedimetric sensors as a tool for monitoring bacterial response to antibiotics.

Lab Chip 2019 Mar 18. Epub 2019 Mar 18.

BioMEMS Group, Institute of Microelectronics of Barcelona (IMB-CNM, CSIC), Esfera UAB-CEI, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

The presence of antimicrobial contaminants like antibiotics in the environment is a major concern because they promote the emergence and the spread of multidrug resistant bacteria. Since the conventional systems for the determination of bacterial susceptibility to antibiotics rely on culturing methods that require long processing times, the implementation of novel strategies is highly required for fast and point-of-care applications. Here the development and characterization of a novel label-free biosensing platform based on a microbial biosensor approach to perform antibiotic detection bioassays in diluted solution is presented. Read More

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http://dx.doi.org/10.1039/c8lc01220bDOI Listing

Simple Evaluation of Pathogenesis Using Animal Model.

Food Sci Anim Resour 2019 Feb 28;39(1):84-92. Epub 2019 Feb 28.

Department of Food and Biotechnology, Korea University, Sejong 30019, Korea.

is a major cause of serious foodborne illness in the dairy foods. Although model is well established as a virulence model of pathogenic bacteria, its application on is critically unclear. The objective of this study was to carry out an evaluation of toxicity using nematode as a simple host model. Read More

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http://dx.doi.org/10.5851/kosfa.2019.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411236PMC
February 2019
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