660,763 results match your criteria Toxicity Mushroom – Orellanine


Effect of microplastics exposure on the photosynthesis system of freshwater algae.

J Hazard Mater 2019 Apr 12;374:219-227. Epub 2019 Apr 12.

Department of Environmental Science and Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China; Institute of Environmental and Resources Technology, Huaqiao University, Xiamen, 361021, China.

Microplastics are widely distributed in freshwater environments. At present, most of the studies on the toxicity of microplastics are concentrated on aquatic feeding animals, but relatively few have addressed freshwater algae. This study investigated the effect of microplastics (polypropylene (PP) and polyvinyl chloride (PVC)) exposure on the photosynthetic system of freshwater algae over the logarithmic growth period. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.039DOI Listing

Graphene oxide induces cardiovascular defects in developing zebrafish (Danio rerio) embryo model: In-vivo toxicity assessment.

Sci Total Environ 2019 Apr 8;673:810-820. Epub 2019 Apr 8.

Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. Electronic address:

Graphene oxide (GO) has wide engineering applications in various areas, including electronics, energy storage, pharmaceuticals, nanomedicine, environmental remediation and biotechnology, because of its unique physico-chemical properties. In the present study, the risk-related information of GO was evaluated to examine the potential ecological and health risks of developmental toxicity. Although the overall developmental toxicity of GO has been well characterized in zebrafish, however, its release effect at a certain concentration of living organisms with specific cardiovascular defects remains largely elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193160
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.082DOI Listing
April 2019
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Oxidative stress: One potential factor for arsenite-induced increase of N-methyladenosine in human keratinocytes.

Environ Toxicol Pharmacol 2019 Apr 13;69:95-103. Epub 2019 Apr 13.

Department of Environmental and Occupational Health, West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address:

N-methyladenosine (mA) modification is affected by oxidative stress and gets involved in arsenite toxicity. However, whether oxidative stress is one factor in arsenite-induced alteration of mA levels remains unclear. Here, reactive oxygen species (ROS), product of lipid peroxidation (MDA), antioxidants (GSH and SOD), mA levels, mA methyltransferases (METTL3, METTL14, and WTAP) and demethylases (FTO and ALKBH5) were detected in human keratinocytes exposed to different concentrations of arsenite. Read More

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http://dx.doi.org/10.1016/j.etap.2019.04.005DOI Listing

Using a hybrid read-across method to evaluate chemical toxicity based on chemical structure and biological data.

Ecotoxicol Environ Saf 2019 Apr 17;178:178-187. Epub 2019 Apr 17.

Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA; Department of Chemistry, Rutgers University, Camden, NJ, USA. Electronic address:

Read-across has become a primary approach to fill data gaps for chemical safety assessments. Chemical similarity based on structure, reactivity, and physic-chemical property information is a traditional approach applied for read-across toxicity studies. However, toxicity mechanisms are usually complicated in a biological system, so only using chemical similarity to perform the read-across for new compounds was not satisfactory for most toxicity endpoints, especially when the chemically similar compounds show dissimilar toxicities. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.019DOI Listing

Study of stainless steel electrodes after electrochemical analysis in sea water condition.

Environ Res 2019 Mar 30;173:549-555. Epub 2019 Mar 30.

Department of Environmental Engineering, Inha University, Incheon, 22212, Republic of Korea. Electronic address:

For water electrolysis, a rare earth material (eg., platinum) is often used as an electrode, but because of the high cost and toxicity of chemicals, researchers are searching for cost effective and eco-friendly alternative materials. Various alloys and metals have been long explored for use as electrode materials in different media. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.069DOI Listing

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

HIPS - Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), Saarland University, Universitätscampus E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. Electronic address:

Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform experiments at air-liquid interface. Epithelial NCI-H441 cells and endothelial HPMEC-ST1. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.037DOI Listing

Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO) exposure on Zebrafish (Danio rerio).

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand; Science and Technology Research Institute, Chiang Mai University, 239 Huay keaw Rd., Suthep, Muang, Chiang Mai 50200, Thailand. Electronic address:

The present study evaluated silver nanoparticle (AgNPs) toxicity using biomarkers of oxidative and metabolic stress, immunological impairment and cellular damage in zebrafish (Danio rerio), as well as the optimal dose of vitamin E neutralizing undesirable effects. Fish were fed for ten days and eight study groups were investigated: controls, AgNPs exposure alone (1.5 mg L) and combined with three different vitamin E doses (1. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.04.004DOI Listing

Oxidative stress and genotoxic effects in earthworms induced by five imidazolium bromide ionic liquids with different alkyl chains.

Chemosphere 2019 Apr 13;227:570-579. Epub 2019 Apr 13.

College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, 61 Daizong Road, Taian, 271018, China. Electronic address:

In this study, the acute and subchronic toxicity of 1-alkyl-3-methyl imidazole bromide ionic liquids (ILs) [Cmim]Br (n = 2, 4, 6, 10, 12) was evaluated utilizing earthworms (Eisenia fetida) as a basis for their impact on terrestrial ecosystems. The filter paper tests and artificial soil tests were conducted as acute toxicity tests to investigate the LC of ILs, while in subchronic toxicity tests, earthworms were exposed to ILs in artificial soil (5, 10, 20 and 40 mg kg) for 28 d. Reactive oxygen species (ROS), antioxidant enzymes, detoxifying enzymes and oxidative damage were measured to determine subchronic effects of ILs on E. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.091DOI Listing

Statistical optimization of glyphosate adsorption by biochar and activated carbon with response surface methodology.

Chemosphere 2019 Apr 11;227:533-540. Epub 2019 Apr 11.

Environmental Bio-innovations Group (EBiG), School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. Electronic address:

The introduction of glyphosate, found in herbicides, to waterbodies is of concern due to its toxicity and hence potential threat to public health and ecological systems. The present study has compared glyphosate removal from aqueous solution with activated carbon and biochar. Box-Behnken design, and percent contribution with Pareto analysis techniques were used in surface response and efficiency calculations modelled the process conditions and their effects. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.078DOI Listing

Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Université de Bourgogne Franche-Comté, Dijon, F-21000, France; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Inserm, F-21000, Dijon, France. Electronic address:

In recent years, a particular interest has focused on the accumulation of fatty acids with very long chains (VLCFA) in the occurrence of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis or dementia. Indeed, it seems increasingly clear that this accumulation of VLCFA in the central nervous system is accompanied by a progressive demyelination resulting in death of neuronal cells. Nevertheless, molecular mechanisms by which VLCFA result in toxicity remain unclear. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.016DOI Listing

Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics.

Toxicol In Vitro 2019 Apr 17. Epub 2019 Apr 17.

Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University Düsseldorf, Postfach 10 10 07, D-40001 Düsseldorf, Germany.

Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate if CO, released from CORMs, inhibits cytochrome P450-dependent monooxygenase (CYP) activity and modulates xenobiotic metabolism. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.018DOI Listing

Exendin-4 attenuates brain mitochondrial toxicity through PI3K/Akt-dependent pathway in amyloid beta (1-42)-induced cognitive deficit rats.

Neurochem Int 2019 Apr 17. Epub 2019 Apr 17.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, 281 406, India.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, disorientation and gradual deterioration of intellectual ability. In the pharmacotherapy of AD, the mitochondrial protective activity of Exendin-4 in experimental studies is yet to be established though its effectiveness is demonstrated in these patients. Therefore, the mitochondria protective activity of Exendin-4 (5 μg/kg, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186193002
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http://dx.doi.org/10.1016/j.neuint.2019.04.006DOI Listing
April 2019
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Low dose of carvacrol prevents rat pancreas tissue damage after L-arginine application, while higher doses cause pancreatic tissue impairment.

Food Chem Toxicol 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia.

Carvacrol (5-isopropyl-2-methylphenol) is a biologically active monoterpene phenol abundantly present in the essential oils of many Lamiaceae aromatic/ethnomedicinal plants. Herein, we aimed to evaluate the damaging effect of carvacrol to rat pancreatic tissue, but also to assess its possible ameliorative impact on pancreatic damage induced by L-arginine. The toxic and beneficial (in a dose of 10 mg/kg) properties of carvacrol were assessed by measuring serum α-amylase and lipase activities, tissue malondialdehyde (MDA) content, and pathohistological changes in pancreatic tissue. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.010DOI Listing

Multifunctional drug carrier based on PEI derivatives loaded with small interfering RNA for therapy of liver cancer.

Int J Pharm 2019 Apr 17. Epub 2019 Apr 17.

Jilin University, School of Life Sciences, Changchun, Jilin, China. Electronic address:

Gene therapy strategies for liver cancer have broad application prospects but still lack a stable and efficient delivery vehicle. To overcome this obstacle, we designed a multifunctional gene delivery vector, sTPssOLP, which was based on oleylamine (OA)-modified disulfide-containing polyethylenimine (PEI) and incorporated into lipids to prepare a lipid nanoparticle. sTPssOLP consisted of the core of PEI derivative and cationic lipids bound to siRNA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193031
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.049DOI Listing
April 2019
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Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro.

Toxicology 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n°, 14040-903, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Thermogenic supplements containing synephrine (SN) are widely used to weight loss. SN is a proto-alkaloid naturally found in the bark of immature fruits of Citrus aurantium (bitter orange) that has been added to thermogenic supplements due to its chemical and pharmacological similarity with adrenergic amines, such as ephedrine and amphetamines. Although orally ingested SN is mainly metabolized in the liver, it remains unclear whether it affects the redox status and genetic material of human hepatic cells. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.010DOI Listing

Systematic optimization of cationic surface engineered mucoadhesive vesicles employing Design of Experiment (DoE): A preclinical investigation.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, M.P. 470 003, India. Electronic address:

Fungal keratitis (FK) is treated by topical natamycin (Nat) which is an effective antifungal agent. However, it has numerous therapeutic limitations i.e. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.118DOI Listing
April 2019
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The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice.

Toxicon 2019 Apr 17. Epub 2019 Apr 17.

Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (Laftambio Pampa), Universidade Federal Do Pampa, Campus Itaqui, 97650-000, Itaqui, RS, Brazil.

The mycotoxin zearalenone (ZEA) has strong estrogenic effects and elicits reproductive toxicity. Chrysin is a natural flavonoid found in many plant and has a broad range of pharmacological activities, including anticancer, antioxidant and anti-inflammatory. The present study aimed to investigate the potential protective effects of chrysin against ZEA toxicity. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.04.004DOI Listing

Investigating the potential of carboxymethyl pullulan for protecting the rabbit eye from systematically induced precorneal tear film damage.

Exp Eye Res 2019 Apr 17. Epub 2019 Apr 17.

Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147 002, Punjab, India. Electronic address:

The present investigation was aimed to develop a rabbit model for protecting the rabbit eye from systematically induced precorneal tear film (PTF) damage, evaluation of carboxymethyl pullulan for its protective action against PTF damage and its curative potential. For the same, pullulan was modified by carboxymethylation and structural modification was confirmed by spectral attributes. Further, the carboxymethyl pullulan (CMP) solutions (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183070
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http://dx.doi.org/10.1016/j.exer.2019.04.017DOI Listing
April 2019
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Involvement of ABC transporters in the efflux and toxicity of MPA-COOH-CdTe quantum dots in human breast cancer SK-BR-3 cells.

J Biochem Mol Toxicol 2019 Apr 20:e22343. Epub 2019 Apr 20.

Department of cardiothoracic surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, PR China.

This paper aimed to study the possible involvement of adenosine triphosphate-binding cassette (ABC) transporters in the detoxification of quantum dots (QDs) in human breast carcinoma (SK-BR-3) cells. The effects of QD sizes on such interactions were also evaluated. For this purpose, we used monodispersed MPA-COOH-CdTe QDs with different diameters (emission length at 560 and 625 nm, named as QD-560 and QD-625). Read More

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http://dx.doi.org/10.1002/jbt.22343DOI Listing

Scopolamine Toxicity in an Elderly Patient.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Anesthesia, Brooke Army Medical Center, 3551 Rodger Brooke Dr, Ft Sam Houston, TX 78234.

We present a case of a 66-year-old female who was to undergo a scheduled operation and placed on our institution's ERAS (Enhanced Recovery After Surgery) protocol. The intraoperative course was unremarkable. The patient developed delayed emergence in the Post-Anesthesia Care Unit. Read More

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http://dx.doi.org/10.1093/milmed/usz086DOI Listing

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria.

Med Res Rev 2019 Apr 19. Epub 2019 Apr 19.

Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.

Bacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug-resistant pathogens has been recognized as an important challenge of the 21st century. Efflux pumps are important in both intrinsic and acquired bacterial resistance and identification of small molecule efflux pump inhibitors (EPIs), capable of restoring the effectiveness of available antibiotics, is an active research field. Read More

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http://dx.doi.org/10.1002/med.21591DOI Listing

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.

Sci Rep 2019 Apr 19;9(1):6333. Epub 2019 Apr 19.

Department of Applied Mathematics, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.

Redox cycling is an understated mechanism of toxicity associated with a plethora of xenobiotics, responsible for preventing the effective treatment of serious conditions such as malaria and cardiomyopathy. Quinone compounds are notorious redox cyclers, present in drugs such as doxorubicin, which is used to treat a host of human cancers. However, the therapeutic index of doxorubicin is undermined by dose-dependent cardiotoxicity, which may be a function of futile redox cycling. Read More

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http://dx.doi.org/10.1038/s41598-019-42799-2DOI Listing

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Department of Molecular Engineering, University of Washington, Seattle, WA 98195;

Alzheimer's disease (AD) is characterized by the deposition of β-sheet-rich, insoluble amyloid β-peptide (Aβ) plaques; however, plaque burden is not correlated with cognitive impairment in AD patients; instead, it is correlated with the presence of toxic soluble oligomers. Here, we show, by a variety of different techniques, that these Aβ oligomers adopt a nonstandard secondary structure, termed "α-sheet." These oligomers form in the lag phase of aggregation, when Aβ-associated cytotoxicity peaks, en route to forming nontoxic β-sheet fibrils. Read More

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http://dx.doi.org/10.1073/pnas.1820585116DOI Listing

Immunotherapy of gynecological cancers.

Best Pract Res Clin Obstet Gynaecol 2019 Mar 21. Epub 2019 Mar 21.

Division of Gynecologic Oncology, Segal Cancer Center, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, Canada. Electronic address:

Oncology treatments have evolved from intuitive, via empiric, to the present precision medicine, with the integration of molecular targeted therapies in our treatment arsenal. The use of the patients' powerful immune system has long been contemplated and recently led to the integration of immunotherapy to overturn the well-documented inhibitory effects of the tumor on the immune system and restore it to a state of activity against the cancer. Recent favorable results have shown the value and effectiveness of immunotherapy against gynecological cancers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216934193003
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http://dx.doi.org/10.1016/j.bpobgyn.2019.03.005DOI Listing
March 2019
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Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Immunology, School of Life Sciences and Biopharmaceuticals Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Guangdong Engineering & Technology Research Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Medical of State Administration of TCM, Guangzhou, 510006, PR China. Electronic address:

Background: Disulfiram (DSF), a drug widely used to control alcoholism, which has anticancer activity by inducing apoptosis in a copper (Cu)-dependent manner. Numerous evidences from mouse experiments indicated that some anti-cancer agents of chemotherapeutic drugs favor the induction of immunogenic cancer cell death (ICD) leading to tumor-specific immune responses. However, whether DSF could induce the colorectal tumor cells death and the mechanism involved in ICD regulatory remains elusive. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.192DOI Listing
April 2019
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Short Cationic Peptidomimetic Antimicrobials.

Antibiotics (Basel) 2019 Apr 18;8(2). Epub 2019 Apr 18.

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. Read More

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https://www.mdpi.com/2079-6382/8/2/44
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http://dx.doi.org/10.3390/antibiotics8020044DOI Listing
April 2019
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Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves-A Comprehensive Review.

Mar Drugs 2019 Apr 18;17(4). Epub 2019 Apr 18.

Department of Biotechnology, Science Campus, Alagappa University, Karaikudi 630 003, India.

Mangroves are ecologically important plants in marine habitats that occupy the coastlines of many countries. In addition to their key ecological importance, various parts of mangroves are widely used in folklore medicine and claimed to effectively manage a panoply of human pathologies. To date, no comprehensive attempt has been made to compile and critically analyze the published literature in light of its ethnopharmacological uses. Read More

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http://dx.doi.org/10.3390/md17040231DOI Listing

Co-assembled Ca Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery.

Mol Ther Nucleic Acids 2019 Mar 28;16:378-390. Epub 2019 Mar 28.

Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; The Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:

Successful gene therapy requires the development of suitable carriers for the selective and efficient delivery of genes to specific target cells, with minimal toxicity. In this work, we present a non-viral vector for gene delivery composed of biocompatible materials, CaCl, plasmid DNA and the semi-synthetic anionic biopolymer alginate sulfate (AlgS), which spontaneously co-assembled to form nanoparticles (NPs). The NPs were characterized with a slightly anionic surface charge (Zeta potential [ζ] = -14 mV), an average size of 270 nm, and their suspension was stable for several days with no aggregation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21622531193006
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http://dx.doi.org/10.1016/j.omtn.2019.03.006DOI Listing
March 2019
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Neuroprotective effect of Dictyopteris divaricata extract-capped gold nanoparticles against oxygen and glucose deprivation/reoxygenation.

Colloids Surf B Biointerfaces 2019 Mar 29;179:421-428. Epub 2019 Mar 29.

Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.

Combination therapy remains a promising approach to ameliorate cerebral ischemia injury. Nevertheless, the primary mechanism of the neuroprotective properties of Dictyopteris divaricata extract-capped gold nanoparticles (DD-GNPs) is not completely understood. DD-GNPs displayed maximum absorption at 525 nm and a diameter of 62. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.066DOI Listing

Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis.

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.001DOI Listing
February 2019

Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis.

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.007DOI Listing
January 2019
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Comparative study of Cu uptake and early transcriptome responses in the green microalga Chlamydomonas reinhardtii and the macrophyte Elodea nuttallii.

Environ Pollut 2019 Apr 10;250:331-337. Epub 2019 Apr 10.

Department F.-A. Forel for Environmental and Aquatic Sciences, Earth and Environmental Sciences, Faculty of Sciences, University of Geneva, 66, Boulevard Carl-Vogt, CH-1211, Geneva 4, Switzerland. Electronic address:

Microalgae are widely used as representative primary producers in ecotoxicology, while macrophytes are much less studied. Here we compared the bioavailability and cellular toxicity pathways of 2 h-exposure to 10 mol L Cu in the macrophyte Elodea nuttallii and the green microalga Chlamydomonas reinhardtii. Uptake rate was similar but faster in the algae than in the macrophyte, while RNA-Sequencing revealed a similar number of regulated genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183557
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http://dx.doi.org/10.1016/j.envpol.2019.04.032DOI Listing
April 2019
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Methylglyoxal in combination with 5-Fluorouracil elicits improved chemosensitivity in breast cancer through apoptosis and cell cycle inhibition.

Biomed Pharmacother 2019 Apr 16;114:108855. Epub 2019 Apr 16.

Dept. of Biophysics, Bose Institute, P 1/12, CIT Scheme VII M, Kolkata, 700 054, WB, India; Dept. of Chemistry, Institute of Applied Science & Humanities GLA University Mathura, 17km Stone, NH-2, Mathura-Delhi Road, Mathura, 281 406, UP, India. Electronic address:

The anti-carcinogenic effect of Methylglyoxal (MG) is well established. It generally targets malignant cells by affecting glycolysis and mitochondrial respiration with minimum or no toxicity to normal cells. In an initial study we have reported that MG can synergistically act with 5-Fluorouracil (5-FU) to decreases the number of MCF-7 breast cancer cells (Ghosh S, Pal A, Ray M, 2017). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108855DOI Listing

QSAR modelling for predicting the toxic effects of traditional and derived biomass solvents on a Danio rerio biomodel.

Chemosphere 2019 Apr 10;227:480-488. Epub 2019 Apr 10.

Universidad San Jorge, Campus Universitario, Autov A23 Km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The increasing interest in the development of ecofriendly solvents has led to the synthesis of benign alternative chemicals with minimized environmental impacts. These kinds of chemicals are known as Green solvents. In this work, we selected three families of solvents (furfural, lactate and levulinate families) derived from biomass that are structurally related. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.054DOI Listing

The forgotten role of toxicodynamics: How habitat quality alters the mite, Oppia nitens, susceptibility to zinc, independent of toxicokinetics.

Chemosphere 2019 Apr 13;227:444-454. Epub 2019 Apr 13.

Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B3; Department of Soil Science, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5A8.

Soil habitat quality is thought to influence metal toxicity via changes in speciation and thereby toxicokinetics. Here, we assessed the toxicokinetic and toxicodynamic effects of habitat quality on mite, Oppia nitens when exposed to zinc (Zn) contaminated soils. Forty-seven soils were ranked into three habitat qualities; high, medium, and low based on biological reproduction of Folsomia candida, Enchytraeus crypticus, and Elymus lanceolatus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193074
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.090DOI Listing
April 2019
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Gut microbiota: An underestimated and unintended recipient for pesticide-induced toxicity.

Chemosphere 2019 Apr 13;227:425-434. Epub 2019 Apr 13.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

Pesticide pollution residues have become increasingly common health hazards over the last several decades because of the wide use of pesticides. The gastrointestinal tract is the first physical and biological barrier to contaminated food and is therefore the first exposure site. Interestingly, a number of studies have shown that the gut microbiota plays a key role in the toxicity of pesticides and has a profound relationship with environmental animal and human health. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.088DOI Listing
April 2019
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PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats.

Chemosphere 2019 Apr 12;227:389-400. Epub 2019 Apr 12.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515, Guangzhou, China. Electronic address:

Polychlorinated biphenyls (PCBs), a kind of persistent organic pollutant, can induce hepatotoxicity in mammals. However, PCB-induced hepatotoxicity in offspring and the underlying mechanisms have been rarely studied. In the present study, Wistar rats were administered with corn oil or PCB52 (1 mg/kg body weight/day, by gavage) from gestational day 7 to postnatal day 21. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.077DOI Listing
April 2019
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Stability and toxicity studies for duloxetine and econazole on Spirodela polyrhiza using chiral capillary electrophoresis.

J Hazard Mater 2019 Apr 5;374:203-210. Epub 2019 Apr 5.

Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares (Madrid), Spain; Instituto de Investigación Química Andrés M. del Río, Universidad de Alcalá, Ctra, Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares (Madrid), Spain. Electronic address:

Stability and toxicity studies for duloxetine and econazole were achieved using individual solutions and their mixtures. Stability of drugs racemates and enantiomers was investigated under abiotic and biotic conditions. Toxicity was evaluated for the first time on Spirodela polyrhiza. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.027DOI Listing

Removal of triclosan in a Fenton-like system mediated by graphene oxide: Reaction kinetics and ecotoxicity evaluation.

Sci Total Environ 2019 Mar 25;673:726-733. Epub 2019 Mar 25.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address:

As a typical nanomaterial, graphene oxide (GO) can be easily dispersed in water and may affect the aqueous environment. In this paper, the degradation of triclosan (TCS) in a Fenton-like system Fe/HO in GO aqueous solution was investigated. Interestingly, it was observed that GO at low concentration (2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193135
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.354DOI Listing
March 2019
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Toxic, cytogenetic and antitumor evaluations of [6]-gingerol in non-clinical in vitro studies.

Biomed Pharmacother 2019 Apr 16;115:108873. Epub 2019 Apr 16.

Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil; Postgraduate Program in Pharmaceutical Sciences, Laboratory of Genetic Toxicology, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil.

Gingerol - [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; [6]-G) - is a phenolic compound with several pharmacological properties. Herein, the aim of the study was to evaluate the toxicogenic effects of [6]-G on Artemia salina nauplii, Allium cepa, HL-60 cell line and Sarcoma 180 (S-180) ascitic fluid cells.For toxic and genotoxic analysis, it was used [6]-G concentrations of 5, 10, 20 and 40 μg mL-1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183570
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http://dx.doi.org/10.1016/j.biopha.2019.108873DOI Listing
April 2019
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Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: Biochemical and histopathological impacts.

Aquat Toxicol 2019 Mar 25;211:181-192. Epub 2019 Mar 25.

Departamento de Biologia & CESAM, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Inappropriate processing and disposal of electronic waste contributes to the contamination of aquatic systems by various types of pollutants such as the rare-earth elements (REE) in which lanthanum (La) is included. Knowledge on the toxicity of these elements in marine organisms is still scarce when compared to other metals such as mercury (Hg) and arsenic (As). Therefore, this study aims to assess the toxicity of La on the mussel Mytilus galloprovincialis, considered a good bioindicator of aquatic pollution, through the analysis of metabolic, oxidative stress, neurotoxicity and histopathological markers. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.03.017DOI Listing

Alkaline earth silicate (AES) wools: Evaluation of potential cyto-genotoxic and inflammatory effects on human respiratory cells.

Toxicol In Vitro 2019 Apr 16. Epub 2019 Apr 16.

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL - Italian Workers' Compensation Authority, Monte Porzio Catone, Rome, Italy.

Biosoluble AES wools are increasingly used since considered not hazardous, however, few toxicity studies are available. We evaluated cytotoxic, genotoxic-oxidative and inflammatory effects of two differently soluble AES wools, AES1 (high MgO percentage) and AES2 (high CaO percentage), on alveolar (A549) and bronchial (BEAS-2B) cells. Fiber dimensions and dissolution in cell media were evaluated by SEM analysis. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.017DOI Listing

Stereotactic Body Radiotherapy Boost for Intermediate Risk Prostate Cancer: A Phase 1 Dose Escalation Study.

Int J Radiat Oncol Biol Phys 2019 Apr 16. Epub 2019 Apr 16.

Sunnybrook Odette Centre; Department of Radiation Oncology, University of Toronto. Electronic address:

Purpose: HDR brachytherapy boost plus external beam radiotherapy is an established option for intermediate risk prostate cancer (PCa). SBRT boost can potentially mimic HDR boost, and could be a viable alternative. Here we report the long-term outcomes of a phase I dose-escalation trial of single-fraction SBRT boost. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.006DOI Listing

Long-term storage of PEGylated liposomal oxaliplatin with improved stability and long circulation times in vivo.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address:

Liposomal anticancer drugs have been developed with improved clinical effects and reduced side effects. We have developed a PEGylated liposomal formulation of oxaliplatin that has anticancer effects in animal models of colorectal cancer with a favorable toxicity profile. To move this formulation into clinical development, a formulation that is stable during long term storage is needed, which has similar pharmacokinetics and therapeutic activity against solid tumors to the original formulation. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.042DOI Listing

Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis.

Biochim Biophys Acta Biomembr 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra 400076, India. Electronic address:

Lipid structure critically dictates the molecular interactions of drugs with membranes influencing passive diffusion, drug partitioning and accumulation, thereby underpinning a lipid-composition specific interplay. Spurring selective passive drug diffusion and uptake through membranes is an obvious solution to combat growing antibiotic resistance with minimized toxicities. However, the spectrum of complex mycobacterial lipids and lack thereof of suitable membrane platforms limits the understanding of mechanisms underlying drug-membrane interactions in tuberculosis. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.04.004DOI Listing

A Correlated Multimodal Approach Reveals Key Details of Nerve-Agent Decomposition by Single Site Zr-Based Polyoxometalates.

J Phys Chem Lett 2019 Apr 19. Epub 2019 Apr 19.

Development of technologies for protection against chemical warfare agents (CWAs) is critically important. Recently, polyoxometalates have attracted attention as potential catalysts for nerve-agent decomposition. The improvement of their effectiveness in real operating conditions requires an atomic-level understanding of CWA decomposition at the gas-solid interface. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b01002DOI Listing

Coupling Langmuir with Michaelis-Menten-A practical alternative to estimate Se content in rice?

PLoS One 2019 19;14(4):e0214219. Epub 2019 Apr 19.

Technical University of Berlin (TUB), Institute of Applied Geosciences, Berlin, Germany.

Selenium plays an important, but vastly neglected role in human nutrition with a narrow gap between dietary deficiency and toxicity. For a potential biofortification of food with Se, as well as for toxicity-risk assessment in sites contaminated by Se, modelling of local and global Se cycling is essential. As bioavailability of Se for rice plants depends on the speciation of Se and the resulting interactions with mineral surfaces as well as the interaction with Se uptake mechanisms in plants, resulting plant Se content is complex to model. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214219PLOS

Surviving Cancer without a Broken Heart.

Rambam Maimonides Med J 2019 Apr 18;10(2). Epub 2019 Apr 18.

Department of Cardiology, Rambam Health Care Campus, Haifa, Israel.

Chemotherapy-associated myocardial toxicity is increasingly recognized with the expanding armamentarium of novel chemotherapeutic agents. The onset of cardiotoxicity during cancer therapy represents a major concern and often involves clinical uncertainties and complex therapeutic decisions, reflecting a compromise between potential benefits and harm. Furthermore, the improved cancer survival has led to cardiovascular complications becoming clinically relevant, potentially contributing to premature morbidity and mortality among cancer survivors. Read More

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http://dx.doi.org/10.5041/RMMJ.10366DOI Listing

Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats.

Int J Med Mushrooms 2019 ;21(4):401-411

College of Veterinary Medicine, National Chung Hsing University, Taichung City, Taiwan.

Recently, erinacine A-enriched Hericium erinaceus (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease. Despite promising results from animal models, there have been no reports on its toxicity after long-term consumption. Hence, the present study was designed to evaluate the safety of EAHE mycelia through a 13-week subchronic rodent feeding study. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030320DOI Listing
January 2019

Gene Delivery Using Lipoplexes and Polyplexes: Principles, Limitations and Solutions.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):29-36

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Gene therapy has attracted considerable attention for the treatment of genetic and acquired diseases. Successful gene therapy occurs when the therapeutic genes penetrate targeted cells and become available to the intracellular active site. Currently, a promising approach in gene delivery is the use of nonviral gene delivery vectors that lack immunogenicity but have low toxicity and potential tissue specificity. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025132DOI Listing
January 2019
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