700,153 results match your criteria Toxicity Mushroom – Hallucinogens


Effects of aging and transformation of anatase and rutile TiO nanoparticles on biological phosphorus removal in sequencing batch reactors and related toxic mechanisms.

J Hazard Mater 2020 May 27;398:123030. Epub 2020 May 27.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, Hohai University, Nanjing, 210098, People's Republic of China; College of Environment, Hohai University, Nanjing, 210098, People's Republic of China.

The effect of nanomaterials aging, namely the transformation of comprehensive characteristics after experiencing real or complex environmental behaviors, on their ecotoxicology is still lacking. Moreover, the mechanisms by which NPs influence biological phosphorus (P) removal during sewage treatment require further elucidation. Therefore, we used both pristine and aged anatase (TiO-A) and rutile (TiO-R) NPs to investigate the mechanisms by which NPs affect P removal in a SBR. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123030DOI Listing

Photochemical transformation of perfluoroalkyl acid precursors in water using engineered nanomaterials.

Water Res 2020 May 20;181:115964. Epub 2020 May 20.

Department of Environmental Science & Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address:

The production of perfluoroalkyl acids (PFAAs) has been phased out over recent decades; however, no significant decline in their environmental concentrations has been observed. This is partly due to the photochemical decomposition of PFAAs precursors (PrePFAAs) which remain in extensive use. The decomposition of PrePFAAs may be accelerated by the light-activated engineered nanomaterials (ENMs) in water. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115964DOI Listing

How to quantify the links between bioavailable contamination in watercourses and pressures of anthropogenic land cover, contamination sources and hydromorphology at multiple scales?

Sci Total Environ 2020 May 17;735:139492. Epub 2020 May 17.

INRAE, UR EABX, F-33612 Cestas, France. Electronic address:

Active biomonitoring permits the quantification of biological exposure to chemicals through measurements of bioavailable concentrations in biota and biological markers of toxicity in organisms. It enables respective comparison of the levels of contamination between sites and sampling campaigns. Caged gammarids are recently proposed as relevant probes for measuring bioavailable contamination in freshwater systems. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139492DOI Listing

Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer.

Int J Pharm 2020 May 31:119482. Epub 2020 May 31.

Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai-400076, India. Electronic address:

Chemotherapy in drug-resistant cancers remains a challenge. Owing to associated poor bioavailability, oral administration of hydrophobic anticancer drugs like paclitaxel has been quite challenging, with the scenario being further complicated by Pgp efflux in drug-resistant tumours. We developed a novel nanocochleates (CPT) system encapsulating paclitaxel (PTX) to treat resistant colon cancer by oral administration. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119482DOI Listing

Zanthoxylum nitidum (Roxb.) DC: Traditional uses, phytochemistry, pharmacological activities and toxicology.

J Ethnopharmacol 2020 May 31:112946. Epub 2020 May 31.

Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China. Electronic address:

Ethnopharmacological Relevance: Zanthoxylum nitidum (Roxb.) DC. (Z. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112946DOI Listing

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.

Biochim Biophys Acta Rev Cancer 2020 May 31:188381. Epub 2020 May 31.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA. Electronic address:

The United State Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable These accounts to an urgent clinical need to discover natural compounds with precisely safe and highly efficient for the cancer prevention and cancer therapy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188381DOI Listing

Comparison of Synthetic Neuronal Model Membrane Mimics in Amyloid Aggregation at Atomic Resolution.

ACS Chem Neurosci 2020 Jun 3. Epub 2020 Jun 3.

Alzheimer's disease (AD) is a severe neurodegenerative disorder caused by abnormal accumulation of toxic amyloid plaques of the amyloid-beta (Aβ) or the tau proteins in the brain. The plaque deposition leading to the collapse of the cellular integrity is responsible for a myriad of surface phenomena acting at the neuronal lipid interface. Recent years have witnessed dysfunction of the blood-brain barriers (BBB) associated with AD. Read More

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http://dx.doi.org/10.1021/acschemneuro.0c00166DOI Listing

Combined approaches for evaluation of xenoestrogen neural toxicity and thyroid dysfunction: Screening of oxido-nitrosative markers, DNA fragmentation, and biogenic amine degradation.

J Biochem Mol Toxicol 2020 Jun 3:e22521. Epub 2020 Jun 3.

Department of Physiology, National Organization for Drug Control and Research, Giza, Egypt.

Anthropogenic chemicals such as parabens and triclosan are used in personal care products. Due to their ability to decrease or prevent bacterial contamination and act as preservatives, these chemicals are used in cosmetic manufacturing processes to increase the shelf life of products. In this study, we assessed the side effects of environmental estrogens (such as the xenoestrogen butylparaben and the antimicrobial agent and preservative triclosan) on thyroid function, brain monoamine levels, and DNA aberration. Read More

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http://dx.doi.org/10.1002/jbt.22521DOI Listing

Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes.

Toxicol Sci 2020 Jun 3. Epub 2020 Jun 3.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA.

A 5-day in vivo rat model was evaluated as an approach to estimate chemical exposures that may pose minimal risk by comparing benchmark dose (BMD) values for transcriptional changes in the liver and kidney to BMD values for toxicological endpoints from traditional toxicity studies. Eighteen chemicals, most having been tested by the NTP in 2-year bioassays, were evaluated. Some of these chemicals are potent hepatotoxicants (e. Read More

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http://dx.doi.org/10.1093/toxsci/kfaa081DOI Listing

Manganese-induced mitochondrial dysfunction is not detectable at exposures below the acute cytotoxic threshold in neuronal cell types.

Toxicol Sci 2020 Jun 3. Epub 2020 Jun 3.

Departments of Pediatrics and Neurology, Vanderbilt University Medical Center, Nashville, TN.

Manganese (Mn) is an essential metal, but excessive exposures have been well-documented to culminate in neurotoxicity. Curiously, the precise mechanisms of Mn neurotoxicity are still unknown. One hypothesis suggests that Mn exerts its toxicity by inhibiting mitochondrial function, which then (if exposure levels are high and long enough) leads to cell death. Read More

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http://dx.doi.org/10.1093/toxsci/kfaa079DOI Listing

All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion.

Invest Ophthalmol Vis Sci 2020 Jun;61(6)

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Purpose: Extracellular accumulation of all-trans-retinaldehyde (atRAL), a highly reactive visual cycle intermediate, is toxic to cells of the outer retina and contributes to retinal and macular degenerations. However, the contribution of atRAL to retinal capillary function has not been studied. We hypothesized that atRAL released from the outer retina can contribute to retinal vascular permeability. Read More

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http://dx.doi.org/10.1167/iovs.61.6.8DOI Listing

Adaptive methodology to determine hydrophobicity of nanomaterials in situ.

PLoS One 2020 3;15(6):e0233844. Epub 2020 Jun 3.

School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, Oregon, United States of America.

The hydrophobicity of nanoparticles (NPs) is a key property determining environmental fate, biological partitioning and toxicity. However, methods to characterize surface hydrophobicity are not uniformly applied to NPs and cannot quantify surface changes in complex environments. Existing methods designed to evaluate the hydrophobicity of bulk solids, chemicals, and proteins have significant limitations when applied to NPs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233844PLOS

Salvage Ipilimumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma After Prior Immune Checkpoint Inhibitors.

J Clin Oncol 2020 Jun 3:JCO1903315. Epub 2020 Jun 3.

Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.

Purpose: Immune checkpoint inhibitors (ICIs) are standard therapy in metastatic renal cell carcinoma (RCC). The safety and activity of the combination of ipilimumab and nivolumab in patients who have received prior ICI targeting the programmed death 1 (PD-1) pathway remains unknown. We evaluated ipilimumab and nivolumab in patients with metastatic RCC after prior treatment with anti-PD-1 pathway-targeted therapy. Read More

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http://dx.doi.org/10.1200/JCO.19.03315DOI Listing

Tox21BodyMap: a webtool to map chemical effects on the human body.

Nucleic Acids Res 2020 Jun 3. Epub 2020 Jun 3.

NIH/NIEHS/DIR/BCBB, RTP, NC 27709, USA.

To support rapid chemical toxicity assessment and mechanistic hypothesis generation, here we present an intuitive webtool allowing a user to identify target organs in the human body where a substance is estimated to be more likely to produce effects. This tool, called Tox21BodyMap, incorporates results of 9,270 chemicals tested in the United States federal Tox21 research consortium in 971 high-throughput screening (HTS) assays whose targets were mapped onto human organs using organ-specific gene expression data. Via Tox21BodyMap's interactive tools, users can visualize chemical target specificity by organ system, and implement different filtering criteria by changing gene expression thresholds and activity concentration parameters. Read More

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http://dx.doi.org/10.1093/nar/gkaa433DOI Listing

BPA toxicity during development of zebrafish embryo.

Braz J Biol 2020 May 20. Epub 2020 May 20.

Programa de Pós-graduação em Ciências Aplicadas à Saúde, Laboratório de Genética e Biologia Molecular, Universidade Federal de Goiás, Jataí, GO, Brasil.

Bisphenol A (BPA) is a monomer used in the production of polycarbonate, a polymer commonly found in plastics, epoxy resins and thermal papers. The presence of BPA in food, water, air and dust has been of great concern in recent years not only due to environmental and ecological issues but also because of its supposed risk to public health related to its mutagenic and carcinogenic potential. In this study we evaluated the toxicity of bisphenol A in zebrafish embryos (Danio rerio) and determined the 50% lethal concentration (LC50) of this chemical. Read More

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http://dx.doi.org/10.1590/1519-6984.230562DOI Listing

Change in malate dehydrogenase and alpha amylase activities in Rubus fruticosus and Valeriana jatamansi treated granary weevil, Sitophilus granarius.

Braz J Biol 2020 Jun 1. Epub 2020 Jun 1.

Department of Biological Science, Karakoram International University, Gilgit Baltistan, Pakistan.

Poor storage conditions provide favorable environment to stored grain pests for their growth. The bio-pesticides are the best alternatives to synthetic pesticides. Present study was conducted to compare toxicity of Rubus fruticosus and Valeriana jatamansi against granary weevil, Sitophilus granarius and subsequent changes in enzyme activity responsible for grain damage. Read More

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http://dx.doi.org/10.1590/1519-6984.226952DOI Listing

An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging.

J Mater Chem B 2020 Jun 3. Epub 2020 Jun 3.

Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing 100190, China. and School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

MRI contrast agents such as paramagnetic Gd(iii)-chelates, can improve the ability of MRI in differentiating diseased and healthy tissues, and have been widely used in clinical diagnosis. However, the enhancement effect of small molecular MRI contrast agents is unsatisfied due to their relative high rotation rates. Furthermore, the small molecular contrast agents also suffer from the short blood half-life and nonspecific extracellular diffusion in tissues, which also restricts their applications. Read More

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http://dx.doi.org/10.1039/d0tb00893aDOI Listing

Elevated amyloidoses of human IAPP and amyloid beta by lipopolysaccharide and their mitigation by carbon quantum dots.

Nanoscale 2020 Jun 3. Epub 2020 Jun 3.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia. and Zhongshan Hospital, Fudan University, 111 Yixueyuan Rd, Xuhui District, Shanghai, 200032, China.

Type 2 diabetes (T2D) and Alzheimer's disease (AD) represent two most prevalent amyloid diseases with a significant global burden. Pathologically, T2D and AD are characterized by the presence of amyloid plaques consisting primarily of toxic human islet amyloid polypeptide (IAPP) and amyloid beta (Aβ). It has been recently revealed that the gut microbiome plays key functions in the pathological progression of neurological disorders through the production of bacterial endotoxins, such as lipopolysaccharide (LPS). Read More

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http://dx.doi.org/10.1039/d0nr02710cDOI Listing

Prenatal exposure to endocrine disrupting chemicals and asthma and allergic diseases.

Authors:
M Casas M Gascon

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

ISGlobal, Barcelona, Spain.

Endocrine-disrupting chemicals (EDCs), chemicals that can interfere with endogenous hormones and that are present in many consumer products, can affect the development and functions of the immune system. The prenatal period is critical because exposure to EDCs can induce irreversible changes in the immune system and increase the susceptibility of asthma and allergies later in life. Non-persistent EDCs are of most concern due to their high annual production and potential toxicity. Read More

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http://dx.doi.org/10.18176/jiaci.0580DOI Listing

Heme Determination and Quantification Methods and Their Suita-bility for Practical Applications and Every-Day-Use.

Anal Chem 2020 Jun 3. Epub 2020 Jun 3.

Many research institutions, clinical diagnostic laboratories, and blood banks are desperately searching for a possibility to identify and quantify heme in different physiological and pathological settings as well as various research applications. The reasons for this are the toxicity of heme and the fact that it acts as hemolytic and pro-inflammatory molecule. Heme only exerts these severe and undesired effects, when it is not incorporated in hemoproteins. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c00415DOI Listing

Phase I Study of Alternate-Day Administration of S-1, Oral Leucovorin, and Bevacizumab for Refractory Metastatic Colorectal Cancer.

Oncologist 2020 Jun 3. Epub 2020 Jun 3.

Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Lessons Learned: The recommended S-1 dose was 40 mg/m , twice daily on Monday, Wednesday, Friday, and Sunday, with oral leucovorin and bevacizumab. Compared with daily administration, the alternate-day administration of S-1 with oral leucovorin may reduce mucositis with promising antitumor activity in refractory metastatic colorectal cancer.

Background: Daily S-1 plus oral leucovorin administration in a 1-week-on/1-week-off schedule has promising efficacy in gastrointestinal cancer but is associated with high risk of mucositis and diarrhea. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0463DOI Listing

Ion release from three different dental alloys - effect of dynamic loading and toxicity of released elements.

Biomater Investig Dent 2020 24;7(1):71-79. Epub 2020 Apr 24.

Nordic Institute of Dental Materials (NIOM), Oslo, Norway.

The aims of this study were to assess if dynamic loading increases the metal ion release of selected dental alloys and to evaluate the cytotoxicity of the released metal ions. One Pd-Ag alloy (Aurolite 2B) and two Co-Cr alloys (Wirobond 280 and d.Sign 30) were investigated. Read More

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http://dx.doi.org/10.1080/26415275.2020.1747471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241566PMC

Rare bone toxicity associated with vismodegib.

JAAD Case Rep 2020 Jun 4;6(6):482-485. Epub 2020 May 4.

Dermatology, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256228PMC

Dataset on the degradation of losartan by TiO-photocatalysis and UVC/persulfate processes.

Data Brief 2020 Aug 14;31:105692. Epub 2020 May 14.

Grupo de Investigación en Remediación Ambiental y Biocatálisis (GIRAB), Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.

Losartan is a highly consumed antihypertensive worldwide and commonly found in effluents of municipal wastewater treatment plants. In the environment, losartan can promote harmful effects on organisms. Thus, an option to face this pollutant is the treatment by photochemical advanced oxidation processes. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262553PMC

Reduced Weekly Subcutaneous Doses of Bortezomib in Combination with Cyclophosphamide and Dexamethasone for Newly Diagnosed Multiple Myeloma.

J Res Pharm Pract 2020 Jan-Mar;9(1):56-59. Epub 2020 Mar 28.

Department of Internal Medicine, Hematology and Oncology Section, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: A combination of bortezomib, cyclophosphamide, and dexamethasone is highly effective in the treatment of newly diagnosed multiple myeloma. Neuropathy is a dose-limiting adverse effect of this regimen. Subcutaneous and weekly injection instead of biweekly intravenous administration are used to reduce neuropathy. Read More

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http://dx.doi.org/10.4103/jrpp.JRPP_18_82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235451PMC

Acute effects of chromium on hemato-biochemical parameters and morphology of erythrocytes in striped catfish .

Toxicol Rep 2020 11;7:664-670. Epub 2020 May 11.

Laboratory of Fish Ecophysiology, Department of Fisheries Management, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.

Chromium is considered the most detrimental pollutant to the aquatic organisms. The present experiment was conducted to determine the acute toxicity of chromium in view of its effects on hemato-biochemical parameters and the structure of erythrocytes in striped catfish, . Fish were exposed to seven different concentrations (0, 10, 20, 30, 40, 50 and 60 mg/L) of chromium, each with three replications for 96 h. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260616PMC

Cadmium sulfide-induced toxicity in the cortex and cerebellum: and studies.

Toxicol Rep 2020 6;7:637-648. Epub 2020 May 6.

Center of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Postal Code 125047, Moscow, Russia.

Living organisms have an innate ability to regulate the synthesis of inorganic materials, such as bones and teeth in humans. Cadmium sulfide (CdS) can be utilized as a quantum dot that functions as a unique light-emitting semiconductor nanocrystal. The increased use in CdS has led to an increased inhalation and ingestion rate of CdS by humans which requires a broader appreciation for the acute and chronic toxicity of CdS. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260592PMC

Acute Fulminant Hepatic Failure and Renal Failure Induced by Oral Amiodarone: A Case Report and Literature Review.

Cureus 2020 May 27;12(5):e8311. Epub 2020 May 27.

Internal Medicine, Jersey Shore University Medical Center, Neptune City, USA.

Amiodarone is a class III antiarrhythmic agent that inhibits adrenergic stimulation by blocking alpha and beta receptors. It prolongs action potential and refractory period in myocardial tissue. Its remarkably long half-life is associated with a myriad of adverse events. Read More

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http://dx.doi.org/10.7759/cureus.8311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255555PMC

A novel tetrapeptide fluorescence sensor for early diagnosis of prostate cancer based on imaging Zn in healthy versus cancerous cells.

J Adv Res 2020 Jul 28;24:363-370. Epub 2020 Apr 28.

Department of Urology, Institute of Urology, Gansu Nephro-Urological Clinical Center, Key Laboratory of Urological Diseases in Gansu Province, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.

Zinc as a biomarker can be used to diagnose the early stage prostate cancer, while ZIP1 protein, a zinc transporter is significantly down-regulated in prostate cancer cells. This behavior leads to the apparent alteration of the enrichment ability for zinc between early prostate cancer tissues and healthy tissues. This difference inspires us to develop a novel Zn sensor that applies to the clinic diagnosis of early prostate cancer. Read More

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http://dx.doi.org/10.1016/j.jare.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256208PMC

Caterpillars on a phytochemical landscape: The case of alfalfa and the Melissa blue butterfly.

Ecol Evol 2020 May 21;10(10):4362-4374. Epub 2020 Apr 21.

Department of Biology Utah State University Logan UT USA.

Modern metabolomic approaches that generate more comprehensive phytochemical profiles than were previously available are providing new opportunities for understanding plant-animal interactions. Specifically, we can characterize the phytochemical landscape by asking how a larger number of individual compounds affect herbivores and how compounds covary among plants. Here we use the recent colonization of alfalfa () by the Melissa blue butterfly () to investigate the effects of indivdiual compounds and suites of covarying phytochemicals on caterpillar performance. Read More

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http://dx.doi.org/10.1002/ece3.6203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246198PMC

Natural products as safeguards against monosodium glutamate-induced toxicity.

Iran J Basic Med Sci 2020 Apr;23(4):416-430

Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory, cognition, learning, as well as cellular metabolism. However, ingestion of foodstuffs rich in monosodium glutamate can result in the outbreak of several health disorders such as neurotoxicity, hepatotoxicity, obesity and diabetes. Read More

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http://dx.doi.org/10.22038/IJBMS.2020.43060.10123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239414PMC

The Power of Phytochemicals Combination in Cancer Chemoprevention.

J Cancer 2020 18;11(15):4521-4533. Epub 2020 May 18.

Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Read More

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http://dx.doi.org/10.7150/jca.34374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255361PMC

Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia.

J Cancer 2020 12;11(15):4373-4383. Epub 2020 May 12.

Cellomics and Toxicogenomics Research Laboratory, NIH/NIMHD-RCMI Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box18750, Jackson, Mississippi, MS 39217, USA.

Trisenox (TX) is successfully used for both de novo and relapsed acute promyelocytic leukemia (APL) treatment. Although TX toxicity to APL cells is mediated by oxidative stress, DNA damage, cell cycle arrest, and apoptosis, its mode of action in the transgenic mice model of APL is poorly understood. We hypothesized that TX regulates cell cycle and apoptosis in APL mice by p53 activation, DNA damage, and reduced expression of MDM2-DAXX-HAUSP complex. Read More

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http://dx.doi.org/10.7150/jca.39996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255370PMC
May 2020
2.639 Impact Factor

Cisplatin-induced renal toxicity in elderly people.

Ther Adv Med Oncol 2020 18;12:1758835920923430. Epub 2020 May 18.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Despite available prevention and treatment measures, such as hydration, diuresis, magnesium supplementation, and amifostine, renal toxicity is still one of the major dose-limiting side effects of cisplatin. The aim of this review is to discuss the issue of cisplatin-induced nephrotoxicity in the elderly. Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, and survival time may be decreased. Read More

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http://dx.doi.org/10.1177/1758835920923430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238313PMC

Efficacy and Safety of Boiss Essential Oil against Acute Toxoplasmosis in Mice.

Iran J Parasitol 2020 Jan-Mar;15(1):22-30

Bam University of Medical Sciences, Bam, Iran.

Background: Broad spectrums of pharmacological properties, including antimicrobial activity have been attributed to Boiss (Laminaceae). The in vivo efficacy and safety of essential oil (ZM-EO) were evaluated against acute toxoplasmosis caused by (Sarcocystidae) in mice.

Methods: (aerial parts) was obtained from the rural districts of Kerman city (Kerman Province) Southwestern Iran, in May of 2016. Read More

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Detection of DNA (8-OHdG) as a toxicity bioindicator to the effects of nickel on Ni-Cr alloy prosthesis users.

Saudi J Biol Sci 2020 Jun 12;27(6):1643-1648. Epub 2020 Mar 12.

Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.

Previous studies have suggested that exposure to Ni from Ni-Cr alloys can affect the human body through oxidative stress. The present study discusses the effect of nickel from Ni-Cr alloy prostheses on the formation of DNA Adduct 8-Hydroxy-2'-Deoxyguanosine (8-OHdG), evaluated based on creatinine and 8-OHdG concentrations in urine, determined with LC-MS/MS, for a Ni-Cr alloy user group and a never-user control group. The mean creatinine and 8-OHdG concentrations were not significantly different between the test groups, although highest levels were observed for the in the Ni-Cr user group. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253878PMC
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