661,001 results match your criteria Toxicity Mushroom – Hallucinogens


Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal.

J Glob Oncol 2019 Apr(5):1-6

4 Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.

Purpose: The purpose of the study was to compare efficacy and toxicity of olanzapine (OLN; a higher-cost drug) and haloperidol (HAL; a lower-cost drug) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC).

Patients And Methods: In a randomized, phase II trial, patients were randomly assigned to receive either OLN 10 mg orally on days 1 to 4 or HAL 1 mg orally on day 1 and 0.5 mg twice daily on days 2 to 4. Read More

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http://dx.doi.org/10.1200/JGO.18.00245DOI Listing

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

Albany Molecular Research, Inc. , 21 Corporate Circle , Albany , New York 12203 , United States.

Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00193DOI Listing

Pro-nifuroxazide Self-Assembly Leads to Triggerable Nanomedicine for Anti-Cancer Therapy.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

Transcription factor STAT3 has been shown to regulate genes that are involved in stem cell self-renewal and thus represents a novel therapeutic target of great biological significance. However, many small molecule agents with potential effects in cancer therapy lack aqueous solubility and high off-target toxicity, hence impeding efficient bioavailability and activity. This work, for the first time, reports a prodrug-based strategy for selective and safer delivery of STAT3 inhibitors designed towards metastatic and drug resistant breast cancer. Read More

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http://dx.doi.org/10.1021/acsami.9b01343DOI Listing

Rediscovery of the Importance of Inorganic Synthesis Parameters in the Search for New Zeolites.

Acc Chem Res 2019 Apr 23. Epub 2019 Apr 23.

Center for Ordered Nanoporous Materials Synthesis, Division of Environmental Science and Engineering , POSTECH , Pohang 37673 , Korea.

Zeolites and related crystalline microporous materials with cavities and channels of molecular dimensions are of major importance for applications ranging from ion-exchange to adsorption and to catalysis. Because their unique shape-selective properties are closely related to the size, shape, and dimensionality of the intracrystalline channels and cavities, much interest has been devoted to the discovery of novel zeolitic materials over the last several decades. As a result, a dramatic expansion in the structural domain of crystalline microporous materials, as well as in their compositional range, has been achieved. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00073DOI Listing

Evaluation of Pertussis Toxin Expression in B2 and THIJS Media.

Arch Razi Inst 2019 Mar 1;74(1):59-67. Epub 2019 Mar 1.

Department of Microbiology and Virology, Faculty of Medical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.

Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi Vaccine and Serum Research Institute is according to bioreactor culture of B. Read More

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http://dx.doi.org/10.22092/ari.2018.110249.1124DOI Listing

Safety, Pharmacokinetics, and Pharmacodynamics of the Autotaxin Inhibitor GLPG1690 in Healthy Subjects: Phase 1 Randomized Trials.

J Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Galapagos Biotech Limited, Cambridge, United Kingdom.

GLPG1690 is a novel autotaxin inhibitor in development for the treatment of idiopathic pulmonary fibrosis (IPF). We report phase 1 studies investigating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of GLPG1690 in healthy subjects. We performed a first-in-human randomized, double-blind, placebo-controlled trial of single (20, 60, 150, 300, 600, 1000, 1500 mg) and multiple (14 days: 150 mg twice daily; 600 and 1000 mg once daily) ascending oral doses of GLPG1690 (NCT02179502), and a randomized, open-label, crossover relative bioavailability study to compare the PK of tablet and capsule formulations of GLPG1690 600 mg and to assess the effect of food on PK of the tablet formulation (NCT03143712). Read More

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http://dx.doi.org/10.1002/jcph.1424DOI Listing

Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 ( Lu-J591) for metastatic castration-resistant prostate cancer.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.

Background: Prostate cancer is radiosensitive. Prostate-specific membrane antigen (PSMA) is selectively overexpressed on advanced, castration-resistant tumors. Lutetium-177-labeled anti-PSMA monoclonal antibody J591 ( Lu-J591) targets prostate cancer with efficacy and dose-response/toxicity data when delivered as a single dose. Read More

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http://dx.doi.org/10.1002/cncr.32072DOI Listing

Advances in lead-free double perovskite nanocrystals, engineering band-gaps and enhancing stability through composition tunability.

Nanoscale 2019 Apr 23. Epub 2019 Apr 23.

Department of Materials Science and Engineering, Technion - Israel Institute of Technology, 32000 Haifa, Israel. and The Solid-State Institute, Technion - Israel Institute of Technology, 32000 Haifa, Israel.

In this topical review, we have focused on the recent advances made in the studies of lead-free perovskites in the bulk form and as nanocrystals. Substitution of lead in halide perovskites is essential to overcome the toxicity concerns and improve the relatively low stability of these materials. In lead-free double perovskites the unit cell is doubled and two divalent lead cations are replaced by mono and trivalent cations. Read More

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http://dx.doi.org/10.1039/c9nr01031aDOI Listing

Cytotoxicity of nanoparticles - Are the size and shape only matters? or the media parameters too?: a study on band engineered ZnS nanoparticles and calculations based on equivolume stress model.

Nanotoxicology 2019 Apr 23:1-16. Epub 2019 Apr 23.

a Department of Physics , Central University of Kerala , Periye, Kasaragod , India, 671320.

Size dependent cytotoxicity of ZnS nanoparticles (NPs) was investigated in Human embryonic kidney (HEK-293) cell lines by MTT assay. The cells were incubated with varying concentration of ZnS NPs of sizes 4 nm, 10 nm and 25 nm for 48 h under different (cell culture) media viscosity conditions. The results showed that the toxicity is decreased with the particle size while it is negatively correlated with the viscosity of the media. Read More

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http://dx.doi.org/10.1080/17435390.2019.1602678DOI Listing

Aluminum oxide nanoparticles mediated toxicity, loss of appendages in progeny of Drosophila melanogaster on chronic exposure.

Nanotoxicology 2019 Apr 23:1-13. Epub 2019 Apr 23.

a Neurobiology Division , Defence Institute of Physiology and Allied Sciences , Delhi , India.

Aluminum oxide (AlO) nanoparticles (NPs) have a wide number of applications which cause intentional and unintentional exposure to humans, making it important to understand the nano-bio interaction. In this study, we made an attempt to evaluate the toxic effects of AlO NPs chronic exposure on Drosophila melanogaster. Flies were exposed to AlO NPs at concentration 0. Read More

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http://dx.doi.org/10.1080/17435390.2019.1602680DOI Listing

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data.

Crit Rev Toxicol 2019 Apr 23:1-14. Epub 2019 Apr 23.

a Integrative Toxicology , Institute of Environmental Medicine, Karolinska Institutet , Stockholm , Sweden.

Computational modeling together with experimental data are essential to assess the risk for particulate matter mediated lung toxicity and to predict the efficacy, safety and fate of aerosolized drug molecules used in inhalation therapy. In silico models are widely used to understand the deposition, distribution, and clearance of inhaled particles and aerosols in the human lung. Exacerbations of chronic obstructive pulmonary disease (COPD) have been reported due to increased particulate matter related air pollution episodes. Read More

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http://dx.doi.org/10.1080/10408444.2019.1584153DOI Listing

An economic evaluation of tofacitinib for the treatment of moderately-to-severely active ulcerative colitis: modeling the cost of treatment strategies in the United States.

J Med Econ 2019 Apr 23. Epub 2019 Apr 23.

d Pfizer, Inc. , Collegeville , PA.

Aims: To evaluate the cost differences between a treatment strategy including tofacitinib (TOFA) versus treatment strategies including adalimumab (ADA), golimumab (GOL), infliximab (IFX), and vedolizumab (VEDO) among all patients with moderate-to-severe ulcerative colitis (UC) (further stratified by patients naïve/exposed to tumor necrosis factor inhibitors [TNFis]).

Materials And Methods: An Excel-based decision-analytic model was developed to evaluate costs from the perspective of a third-party US payer over two years. Efficacy and safety parameters were taken from prescribing information and published trials. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609481DOI Listing

The Influence of In Vitro Assay Setup on the Apparent Cytotoxic Potency of Benzalkonium Chlorides.

Chem Res Toxicol 2019 Apr 23. Epub 2019 Apr 23.

The nominal concentration is generally used to express concentration-effect relationships in in vitro toxicity assays. However, the nominal concentration does not necessarily represent the exposure concentration responsible for the observed effect. Surfactants accumulate at interphases and likely sorb to in vitro system components such as serum protein and well plate plastic. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.8b00412DOI Listing

Halide Perovskite Nanocrystals for Next-Generation Optoelectronics.

Small 2019 Apr 23:e1900801. Epub 2019 Apr 23.

Faculty of Engineering and Natural Sciences, Tampere University, P.O. Box 541, FI-33101, Tampere, Finland.

Colloidal perovskite nanocrystals (PNCs) combine the outstanding optoelectronic properties of bulk perovskites with strong quantum confinement effects at the nanoscale. Their facile and low-cost synthesis, together with superior photoluminescence quantum yields and exceptional optical versatility, make PNCs promising candidates for next-generation optoelectronics. However, this field is still in its early infancy and not yet ready for commercialization due to several open challenges to be addressed, such as toxicity and stability. Read More

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http://dx.doi.org/10.1002/smll.201900801DOI Listing

Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience.

Pediatr Blood Cancer 2019 Apr 22:e27763. Epub 2019 Apr 22.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Radiation therapy (RT) confers local tumor control and survival advantages in some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) population studies are limited.

Methods: Twenty-eight patients treated with curative-intent RT (median dose, 59.4 Gy; range, 40-76 Gy) at our institution from 1990 to 2017 were retrospectively identified. Read More

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http://dx.doi.org/10.1002/pbc.27763DOI Listing

Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.

Int J Rheum Dis 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.

Aim: To assess predictors of alanine aminotransferase (ALT) elevation in methotrexate (MTX) treated rheumatoid arthritis (RA) patients, and to describe the monitoring of liver enzymes, including handling and outcome of elevated ALT.

Methods: All RA patients starting MTX in January, 2005 to April, 2013 at a rheumatology clinic, (Uppsala University Hospital, Sweden) were identified from electronic medical records. Clinical and laboratory data were obtained from medical records, supplemented by telephone interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13576DOI Listing

Utilization of palliative care consultations in pediatric oncology phase I clinical trials.

Pediatr Blood Cancer 2019 Apr 22:e27771. Epub 2019 Apr 22.

Center for Cancer Research, National Cancer Institute, Pediatric Oncology Branch, Bethesda, Maryland.

Pediatric phase I clinical oncology trials represent a unique cohort of patients who have not responded to standard therapies and remain highly vulnerable to treatment toxicity and/or disease burden. Incorporating a palliative care consultation into the care plan for those with relapsed/refractory cancer where chance of cure is limited is generally recommended. A retrospective chart review of pediatric phase I trials revealed that palliative care was consulted in <20% of patients, most often for symptom management. Read More

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http://dx.doi.org/10.1002/pbc.27771DOI Listing

Low-dose azacitidine for relapse prevention after allogeneic hematopoietic cell transplantation in children with myeloid malignancies.

Pediatr Transplant 2019 Apr 23:e13423. Epub 2019 Apr 23.

Seattle Children's Hospital, University of Washington, Seattle, Washington.

Background: The prognosis of children who relapse after allogeneic hematopoietic cell transplant (alloHCT) for myeloid malignancies remains poor.

Procedure: To describe the safety and feasibility of post-transplant azacitidine for relapse prevention, we retrospectively reviewed the charts of 18 children undergoing alloHCT for myeloid malignancies.

Results: There were 15 evaluable patients since three patients did not receive planned azacitidine due to early relapse or TRM. Read More

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http://dx.doi.org/10.1111/petr.13423DOI Listing

Synthesis of Mesoporous Silica/Polyglutamic Acid Peptide Dendrimer with Dual Targeting and Its Application in Dissolving Thrombus.

J Biomed Mater Res A 2019 Apr 22. Epub 2019 Apr 22.

State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.

With the frequent occurrence of thrombus diseases, thrombus has become a factor endangering human health. Nattokinase (NK) is a new generation of thrombolytic drug with efficient thrombolytic effect and no major side effects. However, it is easily inactivated in external environment due to its sensitivity, which is still a challenge for its generalized application. Read More

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http://dx.doi.org/10.1002/jbm.a.36703DOI Listing

Sirolimus-associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient.

Pediatr Transplant 2019 Apr 23:e13425. Epub 2019 Apr 23.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.

Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a potent immunosuppressant that is increasingly used in prevention and treatment of graft-vs-host disease (GVHD) in allogeneic hematopoietic stem cell transplant (HSCT) patients. However, data regarding its adverse effects in HSCT patients remain limited. We describe an 18-year-old HSCT patient with a history of invasive fungal infection, who developed pericardial effusion with cardiac tamponade and interstitial pneumonitis while receiving sirolimus for GVHD prophylaxis. Read More

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http://dx.doi.org/10.1111/petr.13425DOI Listing

Inorganic and Layered Perovskites for Optoelectronic Devices.

Adv Mater 2019 Apr 23:e1807095. Epub 2019 Apr 23.

Department of Physics, University of Konstanz, 78457, Konstanz, Germany.

Organic-inorganic halide perovskites are making breakthroughs in a range of optoelectronic devices. Reports of >23% certified power conversion efficiency in photovoltaic devices, external quantum efficiency >21% in light-emitting diodes (LEDs), continuous-wave lasing and ultralow lasing thresholds in optically pumped lasers, and detectivity in photodetectors on a par with commercial GaAs rivals are being witnessed, making them the fastest ever emerging material technology. Still, questions on their toxicity and long-term stability raise concerns toward their market entry. Read More

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http://dx.doi.org/10.1002/adma.201807095DOI Listing

Antileismanial activity, mechanism of action study and molecular docking of 1,4-bis(substituted benzalhydrazino)phthalazines.

Arch Pharm (Weinheim) 2019 Apr 23:e1800299. Epub 2019 Apr 23.

Department of Chemistry, University of Florida, Gainesville, Florida.

To identify new agents for the treatment of American cutaneous leishmaniasis, a series of eight 1,4-bis(substituted benzalhydrazino)phthalazines was evaluated against Leishmania braziliensis and Leishmania mexicana parasites. These compounds represent a disubstituted version of the 1-chloro-4-(monoaryl/heteroarylhydranizyl)phthalazine that exhibited a significant response against L. braziliensis according to our previous findings. Read More

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http://dx.doi.org/10.1002/ardp.201800299DOI Listing

Synthesis of novel gefitinib-based derivatives and their anticancer activity.

Arch Pharm (Weinheim) 2019 Apr 23:e1800381. Epub 2019 Apr 23.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, India.

Drug latentiation is a process of modifying a drug molecule structurally to improve its binding affinity as well as increasing the drug-receptor interactions and potentiate its therapeutic potential. In the quest for discovering more potent epidermal growth factor receptor (EGFR) inhibitors, gefitinib-based derivatives were designed by simple structural modification at the secondary amine of gefitinib by N-alkylation. Three gefitinib derivatives (gefitinib-NB, -NP, and -NIP) were synthesized by N-alkylation and phase transfer catalysis. Read More

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http://dx.doi.org/10.1002/ardp.201800381DOI Listing

POEMS Syndrome: update on diagnosis, risk-stratification, and management.

Am J Hematol 2019 Apr 22. Epub 2019 Apr 22.

Professor of Medicine and Laboratory Medicine, Mayo Clnic.

Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

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http://dx.doi.org/10.1002/ajh.25495DOI Listing

Quantitative assessment of exposure of heavy metals in groundwater and soil on human health in Reasi district, Jammu and Kashmir.

Environ Geochem Health 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry, Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, Punjab, 143001, India.

The assessment of heavy metal contents in environmental sectors is important to estimate the carcinogenic and non-carcinogenic doses and risks for the mankind associated with it. The present work deals with the assessment of the risk exposure related to heavy metal contents in groundwater and soil samples to two different age groups via three different transits, i.e. Read More

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http://dx.doi.org/10.1007/s10653-019-00294-7DOI Listing

Safe coordinated trafficking of heme and iron with copper maintain cell homeostasis: modules from the hemopexin system.

Biometals 2019 Apr 22. Epub 2019 Apr 22.

School of Biological Sciences, University of Missouri, Kansas, USA.

Studies with patients, animal models of human disease and hemopexin null mice have shown that the heme-binding protein hemopexin is vital for the protection of a variety of cell types and tissues against heme toxicity. The presence of hemopexin in all biological fluids examined to date indicates wide roles in abrogating heme toxicity in human tissues; and, thus, is clinically relevant. Heme-hemopexin endocytosis leads to coordinated trafficking of heme, iron and copper as heme traffics from endosomes to heme oxygenases (HOs) in the smooth endoplasmic reticulum and to the nucleus. Read More

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http://dx.doi.org/10.1007/s10534-019-00194-4DOI Listing

Qualitative and quantitative variations in liver function thresholds among clinical trials in cancer: a need for harmonization.

Cancer Chemother Pharmacol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hematology-Oncology, Tufts Medical Center, Boston, MA, 02111, USA.

Purpose: The liver is critically involved in drug metabolism pathways and the potential for hepatic toxicity is significant with specific cancer therapeutics. Variations in the definition of liver function thresholds that may generate heterogeneity of toxicity and efficacy outcomes across therapeutics trials in cancer require assessment.

Methods: A random sample of therapeutic trials in cancer (n = 500, general category), trials using hepatotoxic drugs (abiraterone, pazopanib: n = 181), trials using drugs metabolized by the liver (doxorubicin, vincristine: n = 606), and therapeutic trials in hepatic dysfunction (n = 49) were each identified on clinicaltrials. Read More

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http://dx.doi.org/10.1007/s00280-019-03821-6DOI Listing

Ectomycorrhizal symbiosis helps plants to challenge salt stress conditions.

Mycorrhiza 2019 Apr 22. Epub 2019 Apr 22.

BPMP, Univ Montpellier, CNRS, INRA, SupAgro, Montpellier, France.

Soil salinity is an environmental condition that is currently increasing worldwide. Plant growth under salinity induces osmotic stress and ion toxicity impairing root water and nutrient absorption, but the association with beneficial soil microorganisms has been linked to an improved adaptation to this constraint. The ectomycorrhizal (ECM) symbiosis has been proposed as a key factor for a better tolerance of woody species to salt stress, thanks to the reduction of sodium (Na) uptake towards photosynthetic organs. Read More

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http://dx.doi.org/10.1007/s00572-019-00894-2DOI Listing

Toxicity Test Assay of Waterborne Methylmercury on the Japanese Flounder (Paralichthys olivaceus) at Embryonic-Larval Stages.

Bull Environ Contam Toxicol 2019 Apr 22. Epub 2019 Apr 22.

CAS Key Laboratory of Marine Ecology and Environment Sciences, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.

Methylmercury (MeHg) is a widespread pollutant in aquatic ecosystems, but its toxicity to the early life stages of marine fish has not been adequately investigated. This study used acute toxicity tests on embryonic-larval stages of a marine flounder Paralichthys olivaceus to determine the LC values for embryos and larvae and evaluate the responses of several biological endpoints to subacute MeHg exposure. Under exposures (0-15 μg L) below LC values ( < 15. Read More

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http://dx.doi.org/10.1007/s00128-019-02619-9DOI Listing

Long-term Clinical Outcomes and Safety Profile of SBRT for Centrally Located NSCLC.

Adv Radiat Oncol 2019 Apr-Jun;4(2):422-428. Epub 2019 Jan 24.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: Previous studies suggest that stereotactic body radiation therapy (SBRT) is associated with higher toxicity rates for central lung tumors relative to peripheral tumors when using 3 fraction SBRT. The initial results from Radiation Therapy Oncology Group study 0813 suggest a safe toxicity profile of SBRT administered in 5 fractions for central non-small cell lung cancer (NSCLC). We reviewed our institutional data to evaluate the safety and efficacy of SBRT for central NSCLC. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460233PMC
January 2019

Early Tolerance Outcomes of Stereotactic Hypofractionated Accelerated Radiation Therapy Concomitant with Pelvic Node Irradiation in High-risk Prostate Cancer.

Adv Radiat Oncol 2019 Apr-Jun;4(2):337-344. Epub 2019 Jan 31.

Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: This study aimed to evaluate the toxicity of prostate and pelvic lymph node stereotactic body radiation therapy (SBRT) for high-risk prostate cancer.

Methods And Materials: Twenty-three patients with high-risk or lymph node-positive prostate cancer were treated with SBRT that delivered 37.5 to 40 Gy in 5 fractions to the prostate and seminal vesicles, with concomitant treatment of the pelvic nodes to 25 Gy. Read More

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http://dx.doi.org/10.1016/j.adro.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460324PMC
January 2019

Initial Results of a Prospective Study of Adjuvant Pancreatic Stereotactic Body Radiation Therapy for Close or Positive Margins.

Adv Radiat Oncol 2019 Apr-Jun;4(2):294-301. Epub 2018 Nov 29.

Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Purpose: Patients with close or positive margins after surgery for pancreatic carcinoma are at a high risk for recurrence. Stereotactic body radiation therapy (SBRT) allows for safe dose escalation with great conformity and short duration of treatment. Herein, we report the initial results of a prospective observational study that evaluated the efficacy and safety of this treatment option. Read More

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http://dx.doi.org/10.1016/j.adro.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460098PMC
November 2018

The effect of breast volume on toxicity using hypofractionated regimens for early stage breast cancer for patients.

Adv Radiat Oncol 2019 Apr-Jun;4(2):261-267. Epub 2018 Nov 1.

Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, Kansas.

Purpose: Hypofractionated radiation therapy (HFRT) remains underused, despite multiple randomized trials showing the equivalence of HFRT to conventional fractionated radiation therapy (CFRT). We sought to retrospectively review the relationship between breast volume and toxicity for HFRT versus CFRT.

Methods And Materials: Data from 114 patients who received a diagnosis of early stage breast cancer and were treated with lumpectomy and whole breast radiation alone were reviewed. Read More

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http://dx.doi.org/10.1016/j.adro.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460101PMC
November 2018

Recurrent Radiation Recall Mucosal Toxicity of the Upper Aerodigestive Tract: A Case Report.

Adv Radiat Oncol 2019 Apr-Jun;4(2):229-232. Epub 2018 Nov 14.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.adro.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460096PMC
November 2018

Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers.

Contemp Clin Trials Commun 2019 Jun 10;14:100361. Epub 2019 Apr 10.

Institute of Immunology and Immunotherapy, University of Birmingham, UK.

We previously reported the safety and efficacy of low dose BaP [ezafibrate (Bez) nd Medroxyrogesterone acetate (MPA)] in 20 acute myeloid leukaemia (AML) patients for whom chemotherapy was not an option. This study provided evidence that BaP had anti-AML activity and improved haemopoiesis; absence of haematological toxicity allowed continuous daily administration. Similarly a previous trial in endemic Burkitt lymphoma demonstrated anti-B cell lymphoma activity of low and high dose BaP again in the absence of toxicity. Read More

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http://dx.doi.org/10.1016/j.conctc.2019.100361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463739PMC

Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency.

Biochem Biophys Rep 2019 Jul 12;18:100623. Epub 2019 Apr 12.

Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway. In this study, K3C16, a propyl spacer bearing lysine type lipids with dihexadecyl moieties (an extension of two hydrocarbon tail length) were compared with K3C14 as liposomes. Such a small change in tail length did not alter the physical properties such as size distribution, zeta potential and polydispersity index (PDI). Read More

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http://dx.doi.org/10.1016/j.bbrep.2019.100623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462779PMC

In Silico Exploration of Aryl Halides Analogues as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and ADMET Screening.

Adv Pharm Bull 2019 Feb 21;9(1):84-92. Epub 2019 Feb 21.

Faculty of Science, Moulay Ismail University, Meknes, Morocco.

In this review, a set of aryl halides analogs were identified as potent checkpoint kinase 1 (Chk1) inhibitors through a series of computer-aided drug design processes, to develop models with good predictive ability, highlight the important interactions between the ligand and the Chk1 receptor protein and determine properties of the new proposed drugs as Chk1 inhibitors agents. Three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking and absorption, distribution, metabolism, excretion and toxicity (ADMET) approaches are used to determine structure activity relationship and confirm the stable conformation on the receptor pocket. The statistical analysis results of comparative -molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) models that employed for a training set of 24 compounds gives reliable values of Q (0. Read More

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http://dx.doi.org/10.15171/apb.2019.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468235PMC
February 2019

and its Derivatives as Food Toxicity Protectant Agents.

Adv Pharm Bull 2019 Feb 21;9(1):22-37. Epub 2019 Feb 21.

Department of Food Science and Technology, Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibiotics residue, mycotoxins, pesticides and some food additives are examples of the most important food toxins. The common mechanism of toxicity and carcinogenicity effects of food toxins is the generation of oxidative stress that leads to DNA damages. Read More

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http://dx.doi.org/10.15171/apb.2019.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468232PMC
February 2019

Acute oral toxicity evaluation of extracts of in wister albino rats as per OECD 425 TG.

Toxicol Rep 2019 4;6:321-328. Epub 2019 Apr 4.

Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Shavige Malleshwara Hills, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India.

(Family: Apiaceae) is a medicinal plant and is been a part of traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Female rats (n=5) were randomly divided into 5 groups. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460325PMC

Bradycardia, Hypotension, and Cardiac Arrest: A Complication of Local Anesthetics.

Cureus 2019 Feb 7;11(2):e4033. Epub 2019 Feb 7.

Cardiology, Maimonides Medical Center, Brooklyn, USA.

Local anesthetics are routinely used in the field of medicine during many procedures, to alleviate acute pain. Although they are relatively safe, they have the ability to produce undesirable neurotoxic and cardiotoxic symptoms when administered intravascularly. Examples of cardiotoxicity include myocardial depression, cardiac arrhythmias, and cardiovascular collapse. Read More

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http://dx.doi.org/10.7759/cureus.4033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456281PMC
February 2019

Interstitial pneumonia in a glassblower: think to chronic beryllium disease!

Pan Afr Med J 2018 9;31:95. Epub 2018 Oct 9.

Medical Intensive Care Unit, Abderrahmen Mami Hospital, Ariana 2080, Tunisia.

Chronic beryllium disease (CBD) is an occupational illness with varying severity. In this report, we describe a 27 year old man, glassblower, who developed a fatal CBD after six months of unknown Beryllium's exposure. The diagnosis was suspected on histological examination and then consolidated by confirmation of Beryllium's exposure at the working area. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.95.14831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462151PMC
October 2018

Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

Evid Based Complement Alternat Med 2019 18;2019:9864841. Epub 2019 Mar 18.

School of Pharmacy, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. Read More

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http://dx.doi.org/10.1155/2019/9864841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442482PMC

Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: Case Series and Review of the Literature.

Case Rep Oncol 2019 Jan-Apr;12(1):260-276. Epub 2019 Mar 21.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

The development of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of patients with advanced stage cancers. However, immune-related adverse events are frequently observed. Cardiac toxicity from ICI therapy can range from asymptomatic troponin-I elevations to conduction abnormalities of the heart and even fulminant myocarditis. Read More

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http://dx.doi.org/10.1159/000498985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465686PMC

Bone Marrow and Peripheral Blood Cells Toxicity of a Single 2.0 Gy Cobalt Ionizing Radiation: An Animal Model.

Ethiop J Health Sci 2019 Mar;29(2):195-202

Department of Haematology and Blood Transfusion, University of Ilorin teaching Hospital, PMB 1459, Ilorin, Nigeri.

Background: Bone marrow is extremely vulnerable to damage caused by radiation therapy. Hence, bone marrow suppression is an important side effect of radiotherapy. Effective use of radiotherapy is therefore compromised by radiation-related injuries. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460448PMC

A safe and potent anti-CD19 CAR T cell therapy.

Nat Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Anti-CD19 chimeric antigen receptor (CAR) T cell therapies can cause severe cytokine-release syndrome (CRS) and neurotoxicity, impeding their therapeutic application. Here we generated a new anti-CD19 CAR molecule (CD19-BBz(86)) derived from the CD19-BBz prototype bearing co-stimulatory 4-1BB and CD3ζ domains. We found that CD19-BBz(86) CAR T cells produced lower levels of cytokines, expressed higher levels of antiapoptotic molecules and proliferated more slowly than the prototype CD19-BBz CAR T cells, although they retained potent cytolytic activity. Read More

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http://dx.doi.org/10.1038/s41591-019-0421-7DOI Listing

Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology.

Sci Rep 2019 Apr 23;9(1):6372. Epub 2019 Apr 23.

Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, 99164-4236, USA.

Ancestral environmental exposures to a variety of factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. One of the most widely used agricultural pesticides worldwide is the herbicide glyphosate (N-(phosphonomethyl)glycine), commonly known as Roundup. There are an increasing number of conflicting reports regarding the direct exposure toxicity (risk) of glyphosate, but no rigorous investigations on the generational actions. Read More

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http://dx.doi.org/10.1038/s41598-019-42860-0DOI Listing

Optimising Clinical Trial Design in Older Cancer Patients.

Geriatrics (Basel) 2018 Jun 22;3(3). Epub 2018 Jun 22.

Discipline of Radiation Therapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.

Cancer is predominantly a disease of older patients, with over half of those aged over 65 years of age being diagnosed with cancer at some stage. Despite comprising a significant proportion of the patients that we see in clinical practice, there is a lack of representation of older patients in cancer clinical trials. This is mainly due to restrictive trial inclusion criteria that prevent older patients from participating. Read More

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http://dx.doi.org/10.3390/geriatrics3030034DOI Listing

Effects of Epacadostat on Brain Extracellular Fluid Concentrations of Serotonin -- An Intracerebral Microdialysis Study in Sprague-Dawley Rats.

Drug Metab Dispos 2019 Apr 22. Epub 2019 Apr 22.

Incyte.

Epacadostat (EPAC) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor that has been examined in multiple clinical trials. The substrate for IDO1 is tryptophan and there is a theoretical concern that inhibition of IDO1 may increase the concentrations of tryptophan and subsequently serotonin, potentially leading to serotonin syndrome (SS). The objective of this study was to evaluate the effect of EPAC, either alone or with linezolid, a monoamine oxidase inhibitor (MAOI), on brain ECF concentrations of serotonin in rats, using microdialysis. Read More

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http://dx.doi.org/10.1124/dmd.118.084053DOI Listing

Efficacy of aerosolized rifaximin versus tobramycin for the treatment of pneumonia in mice.

Antimicrob Agents Chemother 2019 Apr 22. Epub 2019 Apr 22.

Department of Biomedical Sciences, Department of Pediatrics, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25755-9320

is a Gram-negative opportunistic bacterial pathogen that can cause chronic lung infections in patients with cystic fibrosis (CF). The current preferred treatment for CF lung infections includes inhaled tobramycin (TOB); however, studies suggest TOB cannot effectively inhibit biofilm formation. Using a NIH small compounds drug library approved for safe use in humans, we identified rifaximin (RFX), a semisynthetic, rifamycin family, non-systemic antibiotic that inhibits alginate production and growth in Inhibition of alginate production was further analyzed using the uronic acid carbazole assay and a promoter reporter assay that measures the transcription of the alginate biosynthetic operon. Read More

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http://dx.doi.org/10.1128/AAC.02341-18DOI Listing
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