661,139 results match your criteria Toxicity Mushroom – Gyromitra Toxin


Practical considerations for developmental thyroid toxicity assessments: What's working, what's not, and how can we do better?

Regul Toxicol Pharmacol 2019 Apr 21. Epub 2019 Apr 21.

BASF SE, Experimental Toxicology and Ecology, 67056, Ludwigshafen, Germany. Electronic address:

Thyroid hormones (THs; T3 and T4) play a role in development of cardiovascular, reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent studies (during pregnancy, in fetuses, neonates, and adults) is critical in hazard characterization and risk assessment. A roundtable session at the 2017 Society of Toxicology (SOT) meeting brought together academic, industry and government scientists to share knowledge and different perspectives on technical and data interpretation issues. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.04.010DOI Listing

Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity.

Cell Rep 2019 Apr;27(4):1307-1318.e3

Kizil Lab, German Center for Neurodegenerative Diseases (DZNE) Dresden, Helmholtz Association, Tatzberg 41, 01307 Dresden, Germany; Kizil Lab, Technische Universität Dresden, Center for Regenerative Therapies Dresden (CRTD), Fetscherstr. 105, 01307 Dresden, Germany. Electronic address:

The neural stem cell (NSC) reservoir can be harnessed for stem cell-based regenerative therapies. Zebrafish remarkably regenerate their brain by inducing NSC plasticity in a Amyloid-β-42 (Aβ42)-induced experimental Alzheimer's disease (AD) model. Interleukin-4 (IL-4) is also critical for AD-induced NSC proliferation. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.090DOI Listing

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.

Cell Rep 2019 Apr;27(4):1265-1276.e4

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. These organoids derived from BTCs were cultured stably for >1 year and closely recapitulated the histopathology, gene expression, and genetic alterations evident in the primary tumors. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.088DOI Listing

Companion diagnostic tests for treatment of lung cancer patients: what are the current and future challenges?

Expert Rev Mol Diagn 2019 Apr 24. Epub 2019 Apr 24.

b Aix Marseille University , CRCM, INSERM, CNRS, AP-HM, Multidisciplinary Oncology and Therapeutic Innovations Department , Chemin des Bourrely, 13015 , Marseille , France .

Introduction: Companion diagnostic tests (CDXs) are considered mandatory for decision making for treatment with targeted therapies in thoracic oncology. The emergence of immunotherapy has also given rise to the development of CDXs. Some CDXs, in particular PD-L1 immunohistochemistry tests, have been questioned and re-examined for use with new combination therapies that are being evaluated in clinical trials. Read More

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http://dx.doi.org/10.1080/14737159.2019.1611426DOI Listing

Hydroxychloroquine Retinal Toxicity.

N Engl J Med 2019 Apr;380(17):e27

Haverhill, MA.

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http://dx.doi.org/10.1056/NEJMicm1304542DOI Listing

Methanol stem bark extract of Adansonia digitata ameliorates chronic unpredictable mild stress-induced depression-like behavior: Involvement of the HPA axis, BDNF, and stress biomarkers pathways.

J Basic Clin Physiol Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria.

Background Adansonia digitata L. (Malvaceae) is used locally in the management of depressive illnesses, and its antidepressant-like effect has been previously reported. The present study was aimed at determining the effect of the methanol extract of the stem bark of A. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0153DOI Listing

Identification of Novel Phospholipid Transfer Protein Inhibitors by High-Throughput Screening.

SLAS Discov 2019 Apr 24:2472555219842210. Epub 2019 Apr 24.

1 Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Takatsuki, Osaka, Japan.

Atherogenesis has been recognized as a risk factor for lethal cardiovascular diseases. Plasma low-density lipoprotein levels are correlated to the occurrence of atherosclerosis, and their control is critical for both the prevention and treatment of these diseases. Phospholipid transfer protein (PLTP) is one of the key regulators of lipoprotein metabolism; PLTP-deficient mice exhibit decreased apolipoprotein B (apoB)-containing lipoprotein secretion and atherosclerosis, indicating the validity of PLTP as a promising therapeutic target. Read More

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http://dx.doi.org/10.1177/2472555219842210DOI Listing

Lactate dehydrogenase and baseline markers associated with clinical outcomes of advanced esophageal squamous cell carcinoma patients treated with camrelizumab (SHR-1210), a novel anti-PD-1 antibody.

Thorac Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: A small proportion of patients with advanced esophageal squamous cell carcinoma (ESCC) could benefit from immune checkpoint inhibitors; however, reliable peripheral blood biomarkers for outcomes of anti-PD-1 immunotherapy in ESCC have not been identified.

Methods: The data of 43 patients in the ESCC cohort of a phase I trial at our center were retrospectively reviewed. All patients were administered intravenous camrelizumab (SHR-1210), a novel anti-PD-1 antibody, at doses of 60 mg, 200 mg, or 400 mg (4-week interval after first dose followed by a 2-week schedule) until disease progression or intolerable toxicity. Read More

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http://dx.doi.org/10.1111/1759-7714.13083DOI Listing

Localized RNA interference therapy to eliminate residual lung cancer after incomplete microwave ablation.

Thorac Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Minimally Invasive Interventional Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Background: This study evaluated the safety and efficacy of localized injection of polyethylene glycol (PEG)-hyperbranched polyethyleneimine (PEI)-EGFR-small interfering RNA (siRNA) nanocomposites as a treatment for residual lung cancer after incomplete microwave ablation (MWA).

Methods: Human lung cancer cell lines with high and low EGFR expression were selected for the study. The effects of PEG-PEI-EGFR-siRNA nanocomposite transfection on the proliferation, migration, and apoptosis of lung cancer cells were verified. Read More

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http://dx.doi.org/10.1111/1759-7714.13079DOI Listing

Metal Toxicity During Short-Term Sediment Resuspension and Redeposition in a Tropical Reservoir.

Environ Toxicol Chem 2019 Apr 24. Epub 2019 Apr 24.

School for Environment & Sustainability, University of Michigan, Ann Arbor, Michigan, USA.

Billings Complex is the largest water-storage reservoir in São Paulo, Brazil and has been contaminated since the 1960s. Periodically, Billings sediments are subjected to currents causing resuspension and subsequent metals release. A short-term (4 h) resuspension was simulated using Sediment Flux Exposure Chambers (SeFEC) to better understand fate, bioavailability, and transport of iron (Fe), manganese (Mn), and zinc (Zn) during these events and possible organism toxicity. Read More

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http://dx.doi.org/10.1002/etc.4434DOI Listing
April 2019
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The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs.

J Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetes mellitus (DM) and cancer are global problems carrying huge human, social, and economic impact. Type 2 diabetes (T2DM) is associated with an increased risk for a number of cancers, including breast, pancreatic, and liver cancer. Moreover, adverse drug reactions are higher in paitents with cancer with T2DM compared to cancer patients without T2DM. Read More

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http://dx.doi.org/10.1002/jcp.28644DOI Listing

Lizard Tail Extracts Exert Protective Effect Against Oxidative Stress-Induced Cellular Senescence in Human Fibroblasts.

J Med Food 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Biological Science, Dong-A University, Busan, Korea.

Lizards are the evolutionary closest animals to humans among the self-renewable species. Recent reports show that lizard tail extracts (LTE) inhibit the proliferation and angiogenesis of cancer cells but do not show any toxicity against human fibroblast cells. Nevertheless, few scientific studies investigated the effects of LTE on the treatment of skin diseases, especially oxidative stress aging. Read More

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http://dx.doi.org/10.1089/jmf.2018.4369DOI Listing

Endothelial Progenitor Cells Conditioned Medium Supports Number of GABAergic Neurons and Exerts Neuroprotection in Cultured Striatal Neuronal Progenitor Cells.

Cell Transplant 2019 Apr 24:963689719835192. Epub 2019 Apr 24.

1 Department of Neurosurgery, Bern University Hospital, Switzerland.

There is growing evidence that stem and progenitor cells exert regenerative actions by means of paracrine factors. In line with these notions, we recently demonstrated that endothelial progenitor cell (EPC)-derived conditioned medium (EPC-CM) substantially increased viability of brain microvascular cells. In the present study, we aimed at investigating whether EPC-CM supports cell survival of cultured striatal progenitor cells. Read More

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http://dx.doi.org/10.1177/0963689719835192DOI Listing

A Direct-Bandgap 2D Silver-Bismuth Iodide Double Perovskite: The Structure-Directing Influence of an Oligothiophene Spacer Cation.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

Three-dimensional (3D) hybrid organic-inorganic lead halide perovskites (HOIPs) feature remarkable optoelectronic properties for solar energy conversion but suffer from long-standing issues of environmental stability and lead-toxicity. Associated two-dimensional (2D) analogs are garnering increasing interest due to superior chemical stability, structural diversity and broader property tunability. Towards lead-free 2D HOIPs, double perovskites (DPs) with mixed valent dual metals are attractive but remain unexplored beyond a recent 2D Ag-Bi bromide DP with n-butylammonium spacer cations. Read More

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http://dx.doi.org/10.1021/jacs.9b02909DOI Listing

Biogenic approach to synthesize rod shaped Gd O NPs and its optimization using RSM-BBD model.

Biotechnol Prog 2019 Apr 24:e2823. Epub 2019 Apr 24.

Faculty of Chemical and Natural resources Engineering, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia.

The rare earth metal oxide nanoparticles such as gadolinium oxide nanoparticles (Gd O NPs) have been synthesized by green synthesis process using methanolic extract of Moringa oleifera (M. oleifera) peel. In this process, the Gd O NPs formation was observed at 280-300 nm in UV-Vis spectroscopy. Read More

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http://dx.doi.org/10.1002/btpr.2823DOI Listing

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier.

J Appl Toxicol 2019 Apr 24. Epub 2019 Apr 24.

Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, via Celoria 10, I-20133, Milan, Italy.

ZnO nanoparticles (NPs) are widely used nowadays, thus the gastrointestinal exposure to ZnO NPs is likely to be relevant and the effects on the intestinal barrier should be investigated. Polarized Caco-2 cells were exposed from the apical (Ap) and basolateral (Bl) compartments to increasing concentrations (0, 10, 50 and 100 μg/mL) of sonochemical (sono) and commercial ZnO NPs. The transepithelial electrical resistance (TEER), cell viability, proinflammatory cytokine release and presence of protein oxidative damage were evaluated after exposure. Read More

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http://dx.doi.org/10.1002/jat.3800DOI Listing

An overview of the Brazilian contributions to Green Analytical Chemistry.

An Acad Bras Cienc 2019 18;91(suppl 1):e20180294. Epub 2019 Apr 18.

Centro de Energia Nuclear na Agricultura, Universidade de São Paulo, Avenida Centenário, 303, 13400-970 Piracicaba, SP, Brazil.

Green Analytical Chemistry (GAC) is a research field that seeks for more sustainable analytical approaches to minimize the toxicity and amounts of wastes without hindering the analytical performance. This is a trend in Analytical Chemistry worldwide and because of the diversity of innovations on this subject, Brazil stands out as the third in the list of the main contributors to GAC, with ca. 11. Read More

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http://dx.doi.org/10.1590/0001-3765201920180294DOI Listing

The theranostic nanoagent MoC for multi-modal imaging-guided cancer synergistic phototherapy.

Biomater Sci 2019 Apr 24. Epub 2019 Apr 24.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China. and Key Laboratory of Micro-systems and Micro-structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, China.

Multifunctional theranostic platforms, especially single component-based platforms, enable both cancer treatment and real-time imaging as well as enhance the efficiency of treatment. In this study, 50 nm Mo2C nanospheres were explored as a "one-for-all" theranostic agent. The light-harvesting of Mo2C covered the entire near infrared region, and NIR irradiation concurrently triggered hyperthermia and reactive oxygen species (ROS) production; thus, synergistic outcomes of photothermal and photodynamic therapy could be realized. Read More

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http://dx.doi.org/10.1039/c9bm00239aDOI Listing

Comparison of 3D conformal radiation therapy and intensity-modulated radiation therapy in patients with endometrial cancer: efficacy, safety and prognostic analysis.

Acta Oncol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a Department of Radiation Oncology , Tenon University Hospital, Hôpitaux Universitaires Est Parisien, Sorbonne University Medical Faculty , Paris , France.

Introduction: Adjuvant whole-pelvic radiation therapy (WPRT) improves locoregional control for high-intermediate stages I-III endometrial cancer patients. Intensity modulated radiation therapy (IMRT) tends to replace the standard 3D conformal radiation therapy (3DCRT) technique used in trials.

Material And Methods: Consecutive patients with stages I-IIIc endometrial cancer treated between 2008 and 2014 in our department with post-operative 3DCRT or IMRT WPRT were studied retrospectively. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599136DOI Listing

TOXview: a novel graphical presentation of cancer treatment toxicity profiles.

Acta Oncol 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Department of Medical Oncology, Cancer Centre Amsterdam , Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands.

Background: Toxicity profiles play a crucial role in the choice between specific palliative chemotherapy regimens. To optimize the quality of life for cancer patients, patients should be adequately informed about potential toxicities before undergoing chemotherapy. Therefore, we constructed TOXviews, a novel graphical presentation and overview of toxicity profiles to improve information provision about adverse events. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1601256DOI Listing

Safe and sustained expression of human iduronidase after adeno-associated virus 9 intrathecal administration in infant rhesus monkeys.

Hum Gene Ther 2019 Apr 24. Epub 2019 Apr 24.

University of Pennsylvania, Gene Therapy Program , Suite 2000 TRL , 125 S. 31st Street , Philadelphia, Pennsylvania, United States , 19104.

Many neuropathic diseases cause early, irreversible neurologic deterioration, which warrants therapeutic intervention during the first months of life. In the case of mucopolysaccharidosis type I (MPS I), a recessive lysosomal storage disorder that results from a deficiency of the lysosomal enzyme, α-l-iduronidase (IDUA), one of the most promising treatment approaches is to restore enzyme expression through gene therapy. Specifically, administering neurotropic adeno-associated virus (AAV) encoding IDUA into the cerebrospinal fluid (CSF) via suboccipital administration has demonstrated remarkable efficacy in large animals. Read More

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http://dx.doi.org/10.1089/hum.2019.012DOI Listing

Comprehensive Evaluation of Focal Therapy Complications in Prostate Cancer: A Standardised Methodology.

J Endourol 2019 Apr 24. Epub 2019 Apr 24.

Institut Mutualiste Montsouris, 26953, Department of Urology, Paris, France ;

Purpose: Today, up to one-third of newly diagnosed prostate cancer (PCa) cases may be suitable for focal treatment. The lack of data about the toxicity profiles of lesion-targeting therapies, however, have made it difficult to compare treatment modalities. The aim of the present study was to evaluate comprehensively the incidence, severity, and timing of onset of complications for PCa patients undergoing focal high-intensity focused ultrasound (HIFU) and focal cryosurgical ablation of the prostate (CSAP). Read More

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http://dx.doi.org/10.1089/end.2018.0809DOI Listing

Cd influences metabolism and elemental distribution in roots of Acanthus ilicifolius L.

Int J Phytoremediation 2019 Apr 24:1-12. Epub 2019 Apr 24.

a Plant Physiology and Biochemistry Division, Department of Botany , University of Calicut , Malappuram , Kerala , India.

Effect of cadmium (Cd) on the primary metabolic activities and elemental distribution in roots was explored in Acanthus ilicifolius L., a halophyte with phytostabilization potential. The rate of photosynthesis decreased in the CdCl treated plants and this reduction was mainly attributed to the reduction of leaf area, photosynthetic pigments, impaired gaseous exchange caused by the stomatal closure and tissue water status. Read More

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http://dx.doi.org/10.1080/15226514.2019.1577356DOI Listing

Ecotoxicity of 2,4-dinitrotoluene to cold tolerant plant species in a sub-Arctic soil.

Int J Phytoremediation 2019 Apr 24:1-11. Epub 2019 Apr 24.

a a Cold Regions Research and Engineering Laboratory, Biogeochemical Sciences Branch , U.S. Army Engineer Research and Development Center , Hanover , NH , USA.

Decades of live-fire training exercises have left millions of acres of military training lands contaminated with various munitions constituents such as dinitrotoluene. Those that pose a threat to higher organisms due to their toxicity and mobility in the soil are of particular concern. Plants aid in the biodegradation and phytoextraction of contaminants, and site-specific ecotoxicity determinations are critical to inform effective remediation strategy. Read More

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http://dx.doi.org/10.1080/15226514.2019.1583720DOI Listing

Emulsion Techniques for the Production of Pharmacological Nanoparticles.

Macromol Biosci 2019 Apr 24:e1900063. Epub 2019 Apr 24.

Department of Materials Science and Engineering, School of Molecular Science and EngineeringVidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, 21210, Thailand.

Nanoparticles have the advantages over micron-sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Read More

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http://dx.doi.org/10.1002/mabi.201900063DOI Listing

Health effects from unintentional occupational exposure to opioids among law enforcement officers: Two case investigations.

Am J Ind Med 2019 Apr 23. Epub 2019 Apr 23.

National Institute for Occupational Safety and Health, Office of the Director, Washington, District of Columbia.

Recent increases in the rate of drug overdose-related deaths, the emergence of potent opioids such as carfentanil, and media reports of incidents have raised concerns about the potential for work-related exposure to a variety of illicit drugs among law enforcement officers (LEOs), other emergency responders, and other workers in the United States. To characterize the risk associated with unintentional occupational exposure to drugs, we retrospectively investigated two incidents that occurred in 2017 and 2018 where LEOs were exposed to opioid and stimulant drugs and experienced health effects. We interviewed five affected LEOs and others. Read More

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http://dx.doi.org/10.1002/ajim.22967DOI Listing

Treatment and outcome of Unicentric Castleman Disease: a retrospective analysis of 71 cases.

Br J Haematol 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.

We retrospectively analysed 71 cases of Unicentric Castleman disease, a rare, usually asymptomatic, benign lymphoproliferative disorder presenting as a unique nodal mass. Although surgery is considered as the gold standard therapy, only 38 patients (54%) underwent initial surgical resection and 95% were cured. An additional 9 patients had surgery after an attempt at medical reduction. Read More

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http://dx.doi.org/10.1111/bjh.15921DOI Listing

Anti-GD2 antibody-containing immunotherapy postconsolidation therapy for people with high-risk neuroblastoma treated with autologous haematopoietic stem cell transplantation.

Cochrane Database Syst Rev 2019 Apr 24;4:CD012442. Epub 2019 Apr 24.

Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Kerpener Str. 62, Cologne, Germany, 50937.

Background: Neuroblastoma is a rare malignant disease that primarily affects children. The tumours mainly develop in the adrenal medullary tissue, and an abdominal mass is the most common presentation. High-risk disease is characterised by metastasis and other primary tumour characteristics resulting in increased risk for an adverse outcome. Read More

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http://dx.doi.org/10.1002/14651858.CD012442.pub2DOI Listing

Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity by Activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt Signaling Pathways.

Neurotox Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

Peripheral sensory neuropathy (PSN) is a well-known side effect of cisplatin characterized by axonal damage. In the early stage of neurotoxicity, cisplatin affects proteins that modulate neurite outgrowth and neuroplasticity, without inducing mitochondrial damage or apoptosis. There are no preventive therapies for cisplatin-induced peripheral neuropathy; therefore, measures to improve axonal growth and connectivity would be beneficial. Read More

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http://dx.doi.org/10.1007/s12640-019-00042-wDOI Listing

The acceptability of a direct oral anticoagulant monitoring regimen among patients with atrial fibrillation: a pilot study.

Int J Clin Pharm 2019 Apr 17. Epub 2019 Apr 17.

Sydney Medical School, The University of Sydney, Edward Ford Building A27, Sydney, NSW, 2006, Australia.

Background The direct oral anticoagulants (DOACs) offer several advantages over warfarin in the management atrial fibrillation, including the provision of fixed dosing without a requirement for regular monitoring. Recently however the subject of DOAC monitoring has been probed after several post-hoc analyses demonstrated an association between plasma levels and efficacy and safety events. Objective The aim of this pilot study was to explore the acceptability of DOAC plasma monitoring amongst patients with atrial fibrillation and the factors that may influence these attitudes. Read More

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http://dx.doi.org/10.1007/s11096-019-00830-6DOI Listing

System Microscopy of Stress Response Pathways in Cholestasis Research.

Methods Mol Biol 2019 ;1981:187-202

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

Exposure to oxidative radical species and cytokine-mediated inflammatory stress are established contributors to hepatocyte cell death during cholestasis. Cellular counter measures against those stressors are called adaptive stress response pathways. While in early stages of the disease adaptive stress pathways protect the hepatocytes, in later stages during prolonged stressed conditions they fail. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_13DOI Listing
January 2019

Transcriptomic Analysis of Cholestatic Compounds In Vitro.

Methods Mol Biol 2019 ;1981:175-186

KaLy-Cell, Plobsheim, France.

Drug-induced cholestasis is one of the most severe manifestations of drug-induced liver injury. Drug-induced cholestasis is characterized by an accumulation of endogenous metabolites normally excreted in the bile such as bile salts, cholesterol, bilirubin, or drug metabolites. The possibility to determine early in the drug development process whether a compound presents a risk of inducing drug-induced cholestasis is key information. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_12DOI Listing
January 2019

Measuring Apoptosis and Necrosis in Cholestatic Liver Injury.

Methods Mol Biol 2019 ;1981:133-147

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

Cholestasis can be induced by obstruction of bile ducts or intrahepatic toxicity of drugs and chemicals. However, the mode of cell death during cholestasis, i.e. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_9DOI Listing
January 2019

Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy.

Methods Mol Biol 2019 ;1981:99-115

Centro de Química-Física Molecular and Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal.

Cholestasis is characterized by impaired secretion of bile flow that can result in the accumulation of highly abnormal levels of bile acids causing hepatocyte and biliary injury. As amphipathic molecules, bile acids can intercalate in lipid membranes, and pathophysiologic concentrations of bile acids have the potential to induce marked changes in the biophysical properties of biomembranes, including membrane ordering. These effects, particularly on the mitochondrial and plasma membranes, have been proposed to trigger toxicity of bile acids. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_7DOI Listing
January 2019

Behavioural and biochemical parameters in guppy (Poecilia vivipara) following exposure to waterborne zinc in salt or hard water.

Mol Biol Rep 2019 Apr 23. Epub 2019 Apr 23.

Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), Avenida Roraima, 1000, Santa Maria, RS, 97015-900, Brazil.

Zinc is an essential trace mineral that is involved in many biological processes. In elevated concentrations, this metal may have toxic effects for aquatic organisms. Physicochemical properties of water, such as salinity and hardness, can influence the bioavailability of zinc and, therefore its toxicity in aquatic environments. Read More

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http://dx.doi.org/10.1007/s11033-019-04802-xDOI Listing

Chronic exposure to 35% carbamide peroxide tooth bleaching agent induces histological and hematological alterations, oxidative stress, and inflammation in mice.

Environ Sci Pollut Res Int 2019 Apr 24. Epub 2019 Apr 24.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62514, Egypt.

Previous studies have demonstrated the side effects of tooth whiteners on the gastric mucosa. However, the impact of dental bleaching products on the liver, kidney, and heart remains obscure. The present study investigated the toxic potential of 35% carbamide peroxide (CPO) containing tooth whitening product (TWP) on the liver, kidney, heart, and stomach of mice, pointing to the role of oxidative stress and inflammation. Read More

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http://dx.doi.org/10.1007/s11356-019-05100-6DOI Listing

New treatment-induced adverse effects we need to learn as modern hepatologists.

Authors:
Yoshiyuki Ueno

Hepatol Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Gastroenterology, Faculty of Medicine Yamagata University, 2-2-2 Iidanishi, Yamagata, 9909585, Japan.

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http://dx.doi.org/10.1007/s12072-019-09947-2DOI Listing

HDAC-selective Inhibitor Cay10603 Has Single Anti-tumour Effect in Burkitt's Lymphoma Cells by Impeding the Cell Cycle.

Curr Med Sci 2019 Apr 23;39(2):228-236. Epub 2019 Apr 23.

Medical Research Center, Shengjing Hospital, China Medical University, Shenyang, 110004, China.

Histone deacetylases (HDACs) inhibitors are novel in cancer therapy nowadays. HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity. We explored the anti-tumor effect and the molecular mechanism of cay10603, a potent HDAC6 inhibitor in Burkitt's lymphoma cells. Read More

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http://dx.doi.org/10.1007/s11596-019-2024-4DOI Listing

Biomedical applications of polyelectrolyte coated spherical gold nanoparticles.

Nano Converg 2019 Apr 24;6(1):11. Epub 2019 Apr 24.

Flinders Institute for NanoScale Science and Technology, Flinders University, Bedford Park, SA, 5042, Australia.

Surface modified gold nanoparticles are becoming more and more popular for use in biomaterials due to the possibility for specific targeting and increased biocompatibility. This review provides a summary of the recent literature surrounding polyelectrolyte coatings on spherical gold nanoparticles and their potential biomedical applications. The synthesis and layer-by layer coating approach are briefly discussed together with common characterisation methods. Read More

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http://dx.doi.org/10.1186/s40580-019-0183-4DOI Listing

[Active surveillance in prostate cancer].

Urologe A 2019 Apr 23. Epub 2019 Apr 23.

Klinik für Urologie, Eberhard Karls Universität Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland.

Prostate cancer remains among the most commonly diagnosed malignancies worldwide in men. In patients with low-risk prostate cancer, the risk of metastasis and mortality is very low; therefore, a tumor surveillance strategy can be used. In patients undergoing active surveillance, curative active therapy is postponed without compromising opportunities for cure until there is evidence of progression or the patient desires active therapy. Read More

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http://dx.doi.org/10.1007/s00120-019-0921-6DOI Listing

Osteocyte viability and bone density in cadmium chloride-induced osteoporosis ameliorated with stem bark-extracted D-3-O-methy-chiroinositol.

Animal Model Exp Med 2019 Mar 20;2(1):25-33. Epub 2019 Feb 20.

Department of Physiology and Biochemistry Faculty of Veterinary Medicine University of Benin Benin City Nigeria.

Background: This study examined the ameliorative effect of D-3-O-methyl-chiroinositol, isolated from the stem bark of , on cadmium chloride-induced osteoporosis in male Wistar rats.

Methods: Thirty-six rats were assigned to three treatment groups (n = 12). Group A (2 mL distilled water), group B: (2. Read More

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http://dx.doi.org/10.1002/ame2.12054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431122PMC

Biochemical and biophysical study of chemopreventive and chemotherapeutic anti-tumor potential of some Egyptian plant extracts.

Biochem Biophys Rep 2019 Jul 15;18:100637. Epub 2019 Apr 15.

Lecturer Applied Medical Chemistry, Medical Research Institute, Alexandria University, Egypt.

the present study the was done to evaluate chemopreventive and chemotherapeutic anti-tumor potential of some Egyptian plant extract (moringa, graviola, ginger garden cress and artemisinin) against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis in Swiss albino mice. chemopreventive and chemotherapeutic evaluation was assessed by monitoring the tumor incidence and tumor volume as well as by analyzing the status of (a) biochemical markers ( and gene expressions), oxidative stress related profile including; total antioxidant capacity (TAC), glutathione reductase (GR) activity, glutathione-s-transferase (GST) activity assay, superoxide dismutase (SOD) activity, catalase (CAT) activity and lipid peroxidation (MDA), renal and hepatic toxicity markers (urea, creatinine, alanine transaminase (alt) activity, aspartate aminotransferase (ast) activity, alkaline phosphatase (ALP) Activity and γ-Glutamyltransferase (GGT) activity also study of (b) biophysical markers (trace and heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), nickel (Ni), iron (Fe), selenium (Se), copper (Cu) and zinc (Zn)), dielectric properties and body water distribution) finally (c) histopathological examination oral administration of increasing dose of moringa, graviola, ginger garden cress and artemisinin extracts, respectively significantly prevented the tumor incidence and tumor volume as well as brought back the status of the above mentioned biochemical and biophysical variables. Histopathological changes also confirmed the formation of tumor tubules and neovascularization after the treatment. Read More

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http://dx.doi.org/10.1016/j.bbrep.2019.100637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468195PMC

Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells.

Mol Ther Oncolytics 2019 Jun 29;13:58-66. Epub 2019 Mar 29.

Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they are important therapeutic targets. We established PCSC-enriched spheres by culturing human (DU145) and murine (TRAMP-C2) PCa cells in growth factor-defined serum-free medium, and we characterized stem-like properties of clonogenicity and tumorigenicity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23727705193004
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http://dx.doi.org/10.1016/j.omto.2019.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468160PMC
June 2019
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Venetoclax with azacitidine targets refractory MDS but spares healthy hematopoiesis at tailored dose.

Exp Hematol Oncol 2019 16;8. Epub 2019 Apr 16.

Medical Department III for Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany.

Patients with Myelodysplastic Syndromes (MDS) and secondary Acute Myeloid Leukemia (sAML) have a very poor prognosis after failure of hypomethylating agents (HMA). Stem cell transplantation is the only effective salvage therapy, for which only a limited number of patients are eligible due to age and comorbidity. Combination therapy of venetoclax and azacitidine (5-AZA) seems to be a promising approach in myeloid malignancies, but data from patients with HMA failure are lacking. Read More

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http://dx.doi.org/10.1186/s40164-019-0133-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469098PMC

Efficient cell surface labelling of live zebrafish embryos: wash-free fluorescence imaging for cellular dynamics tracking and nanotoxicity evaluation.

Chem Sci 2019 Apr 25;10(14):4062-4068. Epub 2019 Feb 25.

State Key Laboratory of Bioelectronics , School of Biological Science and Medical Engineering , Southeast University , Nanjing , 210096 , P. R. China . Email:

Imaging the dynamics and behaviors of plasma membranes is at the leading edge of life science research. We report here the development of a universal red-fluorescent probe Chol-PEG-Cy5 for wash-free plasma membrane labelling both and . In aqueous solutions, the fluorescence of Chol-PEG-Cy5 is significantly quenched due to the intermolecular resonance energy transfer (RET) between neighbouring Cy5 moieties; however, upon membrane anchoring, the probes undergo lateral diffusion in lipid bilayers, resulting in weakened RET and turn-on fluorescence emission. Read More

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http://dx.doi.org/10.1039/c8sc04884cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461115PMC

Non-stabilized diazoalkane synthesis the oxidation of free hydrazones by iodosylbenzene and application in MIRC cyclopropanation.

Chem Sci 2019 Apr 19;10(13):3802-3806. Epub 2019 Feb 19.

Department of Chemistry , Université de Montréal , P. O. Box 6128 Station Downtown , Montreal , Quebec , H3C 3J7 Canada . Email:

Electron-rich alkyl diazo compounds are powerful reagents in organic synthesis, but the risks associated with their toxicity and instability often limit their uses. Herein we describe an efficient, easy-to-handle and safe batch protocol for the generation and cyclopropanation of these highly reactive non-stabilized diazoalkanes through the oxidation of free hydrazones using iodosylbenzene. Numerous substituted cyclopropanes have been synthesized using this methodology, including various -dimethylcyclopropanes of particular interest in medicinal chemistry. Read More

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http://dx.doi.org/10.1039/c8sc05558kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457201PMC

Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers activation of procaspase-3 to caspase-3.

Medchemcomm 2019 Mar 25;10(3):465-477. Epub 2019 Feb 25.

College of Oceanology and Food Science , Quanzhou Normal University , Quanzhou 362000 , China . Email:

Three series of compounds were designed, synthesized and evaluated for their anticancer activity against a procaspase-3 over-expression cancer cell line (U937) and a procaspase-3 no-expression cancer cell line (MCF-7) to rule out off-target effects. Biological evaluation led to the identification of a series of benzothiazole derivatives bearing a pyridine-semicarbazone moiety, and , with promising anticancer activity and remarkable selectivity. Further mechanism studies revealed that compounds and could induce apoptosis of cancer cells by activating procaspase-3 to caspase-3, and compound exhibited the strongest procaspase-3 activation activity. Read More

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http://dx.doi.org/10.1039/c8md00624eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457200PMC

Synthesis and X-ray study of dispiro 8-nitroquinolone analogues and their cytotoxic properties against human cervical cancer HeLa cells.

Medchemcomm 2019 Mar 22;10(3):439-449. Epub 2019 Jan 22.

School of Chemical Sciences , Bharathiar University , Coimbatore , Tamil Nadu , India . Email: ; Email:

A series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated from the condensation of isatins and benzylamine with ()-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for cytotoxic activity against the human cervical cancer cell line HeLa. Read More

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http://dx.doi.org/10.1039/c8md00482jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457198PMC

Comparative Toxicity Study of Docetaxel and Nanoxel, a Docetaxel-Loaded Micellar Formulation Using Cultured and Blood Cells.

Toxicol Res 2019 Apr 15;35(2):201-207. Epub 2019 Apr 15.

College of Pharmacy, Dongguk University, Goyang, Korea.

Nanoxel-PM (Nanoxel) is a docetaxel-loaded methoxy-poly(ethylene glycol)--poly(D,L-lactide) (mPEG-PDLLA). This newly developed and marketed nanoformulation exhibits an improved pharmacokinetic profile, efficacy, and safety. Although the safety of Nanoxel to docetaxel as well as its bioequivalence must be clinically confirmed, all biological activities have not been examined in or studies. Read More

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http://dx.doi.org/10.5487/TR.2019.35.2.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467357PMC

A 90-Day Repeated Oral Dose Toxicity Study of Aqueous Extract in Rats.

Toxicol Res 2019 Apr 15;35(2):191-200. Epub 2019 Apr 15.

College of Veterinary Medicine BK21 Plus Project Team, Chonnam National University, Gwangju, Korea.

(AR), the dried rhizome of (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an anti-inflammatory agent. The present study was carried out to investigate the potential toxicity of the aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats. Read More

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http://dx.doi.org/10.5487/TR.2019.35.2.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467358PMC
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