703,150 results match your criteria Toxicity Mushroom – Gyromitra Toxin


Regulation of Thyroid Disrupting Chemicals to Protect the Developing Brain.

Endocrinology 2020 Jul 2. Epub 2020 Jul 2.

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, DK, Denmark.

Manmade chemicals with endocrine disrupting properties are pervasive in the environment and are present in the bodies of humans and in wildlife. As thyroid hormones (THs) control normal brain development, and maternal hypothyroxinemia is associated with neurological impairments in children, chemicals that interfere with TH signaling are of considerable concern for children's health. However, identifying thyroid disrupting chemicals (TDCs) in vivo is largely based on serum tetraiodothyronine (T4) measures in rats, which may be inadequate to assess TDCs with disparate mechanisms of action. Read More

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http://dx.doi.org/10.1210/endocr/bqaa106DOI Listing

Combination of computed tomography-guided iodine-125 brachytherapy and bronchial arterial chemoembolization for locally advanced stage III non-small cell lung cancer after failure of concurrent chemoradiotherapy.

Lung Cancer 2020 Jun 20;146:290-296. Epub 2020 Jun 20.

Department of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, China; Interventional Oncology Institute of Shandong University, China. Electronic address:

Objectives: To evaluate the efficacy and safety of the combination of computed tomography (CT)-guided iodine-125 brachytherapy and bronchial arterial chemoembolization (BACE) for locally advanced stage III non-small cell lung cancer (NSCLC) after failure of concurrent chemoradiotherapy.

Material And Methods: We retrospectively evaluated 28 patients with locally advanced stage III NSCLC in whom concurrent chemoradiotherapy had failed and were consequently, treated with radioactive iodine-125 seed implantation followed by BACE. The prescribed radiation dose was 140 Gy, with a median radioactivity of 0. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.010DOI Listing

c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism.

Colloids Surf B Biointerfaces 2020 Jun 25;194:111211. Epub 2020 Jun 25.

Department of Applied Physiology, School of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan.

Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111211DOI Listing

ROS triggered cleavage of thioketal moiety to dissociate prodrug nanoparticles for chemotherapy.

Colloids Surf B Biointerfaces 2020 Jun 25;194:111223. Epub 2020 Jun 25.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address:

With the utilization of high concentration reactive oxygen species (ROS) in tumor microenvironment, PEG-doxorubicin (PEG-DOX) prodrug was synthesized via a thioketal moiety as the linker, which was ROS cleavable to trigger DOX release from the self-assembled prodrug nanoparticles. The in vitro ROS sensitivity of prodrug nanoparticles (NPs) was investigated in Fenton agent and HO, and the disassembly of NPs was more sensitive to Fenton reagent. After internalized in HepG2 cells via endocytosis, the cellular ROS consuming test revealed intracellular DOX release. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111223DOI Listing

Assessment of reproductive and developmental effects of graphene oxide on Japanese medaka (Oryzias latipes).

Chemosphere 2020 Jun 22;259:127221. Epub 2020 Jun 22.

RCMI Center for Environmental Health, Jackson State University, Jackson, MS, 39217, USA. Electronic address:

Due to its unique properties, graphene oxide (GO) has potential for biomedical and electronic applications, however environmental contamination including aquatic ecosystem is inevitable. Moreover, potential risks of GO in aquatic life are inadequately explored. Present study was designed to evaluate GO as an endocrine disrupting chemical (EDC) using the model Japanese medaka (Oryzias latipes). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127221DOI Listing

Lead and copper-induced hormetic effect and toxicity mechanisms in lettuce (Lactuca sativa L.) grown in a contaminated soil.

Sci Total Environ 2020 Jun 23;741:140440. Epub 2020 Jun 23.

College of Tropical Crops, Hainan University, Haikou, Hainan 570228, China. Electronic address:

Lead (Pb) and copper (Cu) contamination seriously threatens agricultural production and food safety. This study aims to investigate Pb and Cu induced hormetic effect and toxicity mechanisms in lettuce (Lactuca sativa L.) and establish reliable empirical models of potentially toxic elements (PTEs) transfer in the soil-plant system. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140440DOI Listing

Antitumor potential of dark sweet cherry sweet (Prunus avium) phenolics in suppressing xenograft tumor growth of MDA-MB-453 breast cancer cells.

J Nutr Biochem 2020 May 28;84:108437. Epub 2020 May 28.

Department of Nutrition and Food Science, Texas A&M University, College Station, TX, USA.

This study investigated in vivo the antitumor activity of dark sweet cherry (DSC) whole extracted phenolics (WE) and fractions enriched in anthocyanins (ACN) or proanthocyanidins (PCA) in athymic mice xenografted with MDA-MB-453 breast cancer cells. Mice were gavaged with WE, ACN or PCA extracts (150 mg/kg body weight/day) for 36 days. Results showed that tumor growth was suppressed at similar levels by WE, ACN and PCA compared to control group (C) without signs of toxicity or significant changes in mRNA oncogenic biomarkers in tumors or mRNA invasive biomarker in distant organs. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108437DOI Listing

Targeting histone acetylation/deacetylation in parasites: an update (2017-2020).

Curr Opin Chem Biol 2020 Jun 29;57:65-74. Epub 2020 Jun 29.

Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. Electronic address:

Histone modifying enzymes have vital roles in the growth and survival of both parasites and humans. Targeting the epigenome can be a new strategy for the treatment of parasitic diseases. Compounds modulating histone acetylation/deacetylation have recently been reported hampering Plasmodium, Schistosoma, Leishmania, and Trypanosoma infections. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.05.008DOI Listing

Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos.

Environ Int 2020 Jun 29;143:105913. Epub 2020 Jun 29.

Unit of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden. Electronic address:

Polycyclic aromatic compounds (PACs), including polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (oxy-PAHs), are common environmental pollutants known to cause health effects in humans and wild-life. In particular, vertebrate cardiovascular development and function are sensitive to PACs. However, the interactive effects of PAHs and oxy-PAHs on cardiovascular endpoints have not been well studied. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105913DOI Listing

Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut.

Environ Int 2020 Jun 29;143:105916. Epub 2020 Jun 29.

Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Increasing evidence shows that microplastics (MPs) have the potential to act as carriers and transport contaminants into organisms, as well as induce serious health risks. Here we endeavored to address for the first time whether MPs could transport and release phthalate esters (PAEs) into mouse gut and the consequential toxic effects. As a result, MPs could adsorb PAEs, transport PAEs into the gut and cause intestinal accumulation. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105916DOI Listing

Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics.

Nanomedicine 2020 Jun 29:102258. Epub 2020 Jun 29.

Center for NanoHealth, Swansea University Medical School.

High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (<90 μg/day). To enable the successful exploitation of selenium for cancer treatment, we evaluated inorganic selenium nanoparticles (SeNP), and found them effective in inhibiting ovarian cancer cell growth. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102258DOI Listing

Predictors of Adverse Radiation Effect in Brain Metastasis Patients Treated with Stereotactic Radiosurgery and Immune Checkpoint Inhibitor Therapy.

Int J Radiat Oncol Biol Phys 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC.

Background: Immune checkpoint inhibitor therapy (ICI) has recently been found to improve survival in patients with a number of cancers and includes those with metastatic disease. There is an association of adverse radiation effect (ARE) in patients with brain metastases who have been treated with stereotactic radiosurgery (SRS) and immune checkpoint inhibitors.

Methods And Materials: Single institution retrospective review identified 1118 brain metastases treated with SRS between 2013-2018 and who had received ICI and 886 metastases who did not receive ICI. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.057DOI Listing

Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent.

Eur J Pharm Sci 2020 Jun 29:105439. Epub 2020 Jun 29.

Department of Drug Technology and Biotechnology, Faculty of Chemistry, Warsaw University of Technology,75 Koszykowa Str, 00-664 Warsaw, Poland.

Glioblastoma multiforme (GBM) is a one of the most widely diagnosed and difficult to treat type of central nervous system tumors. Resection combined with radiotherapy and temozolomide (TMZ) chemotherapy prolongs patients' survival only for 12 - 15 months after diagnosis. Moreover, many patients develop TMZ resistance, thus important is search for a new therapy regimes including targeted drug delivery. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105439DOI Listing

Ochratoxin A induces glomerular injury through activating the ERK/NF-κB signaling pathway.

Food Chem Toxicol 2020 Jun 29:111516. Epub 2020 Jun 29.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China. Electronic address:

Ochratoxin A (OTA) was reported to induce proximal tubules nephrotoxicity in humans and animals. However, the toxicity of OTA on glomeruli has rarely been studied. We investigated OTA-induced glomerular injury and the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111516DOI Listing

A Review on Dental Whitening.

J Dent 2020 Jun 29:103423. Epub 2020 Jun 29.

School of Dental Sciences, Newcastle University, Framlington Place, Newcastle-upon-Tyne, Tyne and Wear, NE2 4BW, United Kingdom.

Objectives: To provide a narrative review on vital dental whitening chemistry, toxicity and safety, vital dental whitening techniques, whitening systems, potential side effects of whitening and cyclic whitening using products with a range of concentrations and pH values. In addition, new developments and recommendations in the field of vital dental whitening will be presented to help clinicians understand the whitening process, its advantages, limitations, and the impact of whitening concentration and pH on enamel providing guidance in tailoring whitening treatments.

Data: Data were gathered using the following keywords: dental whitening, roughness, hardness, sensitivity, hydrogen peroxide, whitening pH, whitening concentration, whitening chemistry, colour, and toxicity. Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103423DOI Listing

Increased putrescine levels due to ODC1 overexpression prevents mitochondrial dysfunction-related apoptosis induced by methylmercury.

Life Sci 2020 Jun 29:118031. Epub 2020 Jun 29.

Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. Electronic address:

Aims: We had previously reported that addition of putrescine to the culture medium was reported to reduce methylmercury toxicity in C17.2 neural stem cells. Here, we have examined the inhibition of methylmercury-induced cytotoxicity by putrescine using ODC1-overexpressing C17. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118031DOI Listing

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.

Cell 2020 Jun 24. Epub 2020 Jun 24.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Department of Pathology, New York University School of Medicine, New York, NY, USA. Electronic address:

Targeting glycolysis has been considered therapeutically intractable owing to its essential housekeeping role. However, the context-dependent requirement for individual glycolytic steps has not been fully explored. We show that CRISPR-mediated targeting of glycolysis in T cells in mice results in global loss of Th17 cells, whereas deficiency of the glycolytic enzyme glucose phosphate isomerase (Gpi1) selectively eliminates inflammatory encephalitogenic and colitogenic Th17 cells, without substantially affecting homeostatic microbiota-specific Th17 cells. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.014DOI Listing

GR-C/EBPα-IGF1 axis mediated azithromycin-induced liver developmental toxicity in fetal mice.

Biochem Pharmacol 2020 Jun 29:114130. Epub 2020 Jun 29.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Azithromycin is considered an effective drug to treat the perinatal mycoplasma infection. However, there is a lack of studies on developmental toxicity of azithromycin. In this study, we observed the developmental toxicity of fetal liver induced by prenatal azithromycin exposure (PAE) in mice and explored the potential mechanism. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114130DOI Listing

A New Molecular-Mechanics Model for Simulations of Hydrogen Fluoride in Chemistry and Biology.

J Chem Theory Comput 2020 Jul 2. Epub 2020 Jul 2.

Hydrogen fluoride (HF) is the most polar diatomic molecule and one of the simplest molecules capable of hydrogen-bonding. HF deviates from ideality both in the gas phase and in solution, and is thus of great interest from a fundamental standpoint. Pure and aqueous HF solutions are also broadly used in chemical and industrial processes, despite their high toxicity. Read More

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http://dx.doi.org/10.1021/acs.jctc.0c00247DOI Listing

DLBCL patients treated with CD19 CAR T cells experience a high burden of organ toxicities but low nonrelapse mortality.

Blood Adv 2020 Jul;4(13):3024-3033

Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity syndrome are the most notable toxicities of CD19 chimeric antigen receptor (CAR) T-cell therapy. In addition, CAR T-cell-mediated toxicities can involve any organ system, with varied impacts on outcomes, depending on patient factors and involved organs. We performed detailed analysis of organ-specific toxicities and their association with outcomes in 60 patients with diffuse large B-cell lymphoma (DLBCL) treated with CD19 CAR T cells by assessing all toxicities in organ-based groups during the first year posttreatment. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001972DOI Listing

Red elemental selenium nanoparticles mediated substantial variations in growth, tissue differentiation, metabolism, gene transcription, epigenetic cytosine DNA methylation, and callogenesis in bittermelon (Momordica charantia); an in vitro experiment.

PLoS One 2020 2;15(7):e0235556. Epub 2020 Jul 2.

Department of Biology, Garmsar Branch, Islamic Azad University, Garmsar, Iran.

To gain a better insight into the selenium nanoparticle (nSe) benefits/toxicity, this experiment was carried out to address the behavior of bitter melon seedlings to nSe (0, 1, 4, 10, 30, and 50 mgL-1) or bulk form (selenate). Low doses of nSe increased biomass accumulation, while concentrations of 10 mgL-1 and above were associated with stem bending, impaired root meristem, and severe toxicity. Responses to nSe were distinct from that of bulk in that the nano-type exhibited a higher efficiency to stimulate growth and organogenesis than the bulk. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235556PLOS

Pharmacological Uses of the Plants Belonging to the Genus Commiphora.

Cardiovasc Hematol Agents Med Chem 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandam Palayam Post, Erode, Tamil Nadu. India.

Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. Read More

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http://dx.doi.org/10.2174/1871525718666200702125558DOI Listing

Synthesis, in-vitro and in-silico evaluation of Silver Nanoparticles with Root Extract of Withania somnifera for antibacterial activity via binding of penicillin binding protein-4.

Curr Pharm Biotechnol 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology Mesra, Ranchi, Jharkhand. India.

Background: Metal nanoparticles (NPs) have been widely used for various applications in biomedical sciences including in drug delivery, and as therapeutic agents, but limited owing to their toxicity towards the healthy tissue. This warrants an alternative method, which can achieve the desired activity with much reduced or no toxicity. Being a biological product, Withania somnifera (W. Read More

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http://dx.doi.org/10.2174/1389201021666200702152000DOI Listing

Annonaceae family alkaloids as agents against leishmaniasis: review and molecular docking evaluation.

Curr Drug Metab 2020 Jul 2. Epub 2020 Jul 2.

Federal University of Paraíba, João Pessoa. Brazil.

Leishmaniasis is a neglected disease that affects 15 million people, worldwide. Existing treatments are associated with limitations, including high costs and toxicity. Several classes of natural substances have been reported to display leishmanicidal activity in the literature. Read More

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http://dx.doi.org/10.2174/1389200221666200702124046DOI Listing

Efficacy of sodium hypochlorite in the degradation antineoplastic drugs by NMR spectroscopy.

G Ital Med Lav Ergon 2020 Jun;42(2):109-120

University of Rome La Sapienza - Department of Chemistry (S. Cannizzaro Building), Piazzale Aldo Moro 5, 00185 Rome, Italy.

Summary: Antineoplastic drugs are used to treat cancer, having their therapeutic effect by inhibiting the cell division process. Although cancer cells, due to their rapid growth, are more sensitive to the toxic effects of chemotherapeutic agents, healthy cells and tissues may also be damaged. Many studies show acute and chronic toxicity both in patients treated with chemotherapy and in exposed workers. Read More

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Neutrophil-targeted engineered prodrug nanoparticles for anti-inflammation.

Authors:
Jinping Shi Juan Li

FASEB J 2020 Jul 2. Epub 2020 Jul 2.

Advanced Research Institute for Multidisciplinary Science, Beijing Institute of Technology, Beijing, China.

Inflammation response is a defense to infection induced by invading pathogen or tissue injury. However, exaggerated inflammation may cause autoimmune or inflammatory disorders, such as acute respiratory distress syndrome, sepsis, stroke and rheumatoid arthritis. Anti-inflammatory agents and anti-cytokine therapy have been developed to inhibit inflammation pathways and neutralize cytokine storm, but the off-targeting delivery and damage in immune system cause systemic severe side-effect. Read More

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http://dx.doi.org/10.1096/fj.202000978RRDOI Listing

Improved survival in patients with FDG-PET/CT-based radiotherapy treatment planning for squamous cell anal cancer.

Neoplasma 2020 Jul 2. Epub 2020 Jul 2.

Department of Oncology, Second Faculty of Medicine of Charles University and Motol Hospital, Prague, Czech Republic.

The aim of this retrospective analysis was to evaluate the impact of FDG-PET/CT-based target volume definition on locoregional control and survival, compared to conventional CT-based target volume definition and dose prescription. One hundred and twenty-two patients with squamous cell anal cancer were treated with curative radiotherapy (RT) alone (27%) or with RT with concurrent chemotherapy (73%) and analyzed. Forty-six percent had the early disease (stage I+II) and 54% were stage III. Read More

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http://dx.doi.org/10.4149/neo_2020_191229N1350DOI Listing

Microcystins: biogenesis, toxicity, analysis and control.

Chem Res Toxicol 2020 Jul 2. Epub 2020 Jul 2.

Microcystins are cyclic peptide toxins formed by cyanobacteria. These toxins are recognized for their association with algal blooms, posing a significant threat to ecosystems and drinking water quality. Due to the growing environmental concerns they raise, a comprehensive review on microcystins' genesis, toxicity, and analytical methods for their quantitative determination is outlined. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.0c00164DOI Listing

Platform to study intracellular polystyrene nanoplastic pollution and clinical outcomes.

Stem Cells 2020 Jul 2. Epub 2020 Jul 2.

SPEBO Medical Fertility Hospital, Leskovac, Serbia.

Increased pollution by plastics has become a serious global environmental problem, but the concerns for human health have been raised after reported presence of microplastics (MPs) and nanoplastics (NPs) in food and beverages. Unfortunately, few studies have investigate the potentially harmful effects of MPs/NPs on early human development and human health. Therefore, we used a new platform to study possible effects of polystyrene NPs (PSNPs) on the transcription profile of preimplantation human embryos and human induced pluripotent stem cells (hiPSCs). Read More

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http://dx.doi.org/10.1002/stem.3244DOI Listing

Predicting coated-nanoparticle drug release systems with perturbation-theory machine learning (PTML) models.

Nanoscale 2020 Jul;12(25):13471-13483

Department of Organic Chemistry II, University of Basque Country UPV/EHU, 48940, Leioa, Spain. and IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain and Biofisika Institue CSIC-UPVEHU, University of Basque Country UPV/EHU, 48940, Leioa, Spain.

Nanoparticles (NPs) decorated with coating agents (polymers, gels, proteins, etc.) form Nanoparticle Drug Delivery Systems (DDNS), which are of high interest in nanotechnology and biomaterials science. There have been increasing reports of experimental data sets of biological activity, toxicity, and delivery properties of DDNS. Read More

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http://dx.doi.org/10.1039/d0nr01849jDOI Listing

Helical IMRT-Based Stereotactic Body Radiation Therapy Using an Abdominal Compression Technique and Modified Fractionation Regimen for Small Hepatocellular Carcinoma.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820937002

Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.

Purpose: To assess the efficacy and safety of stereotactic body radiation therapy using an abdominal compression technique and modified fractionation regimen (5-10 fractions) in patients with small-sized hepatocellular carcinoma.

Methods: A total of 101 patients with small-sized hepatocellular carcinoma treated with stereotactic body radiation therapy using an abdominal compression technique and modified fractionation regimen were registered between June 2011 and June 2019 in our hospital. A total dose of 48 to 60 Gy was applied over 5 to 14 consecutive days. Read More

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http://dx.doi.org/10.1177/1533033820937002DOI Listing

[RNAissance: is there a future for RNA therapeutics?]

Ned Tijdschr Geneeskd 2020 Jun 4;164. Epub 2020 Jun 4.

LUMC, afd. Interne Geneeskunde, Leiden(tevens: EinthovenLaboratoryforVascularandRegenerativeMedicine).

The central dogma in molecular biology states that genetic information is transmitted from DNA to RNA to proteins, but not the other way round. Thanks to a recent technological revolution - the 'RNAissance' - it has, however, become clear that RNA is not solely a messenger for passing on the genetic information necessary for protein synthesis, but that RNA also plays an important role in sickness and health. In the past 5 years alone more than 100 therapies with (complementary) RNA molecules have been investigated in Phase 1 trials, and a quarter of these have also been investigated in Phase 2 or 3 trials. Read More

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Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity.

Adv Healthc Mater 2020 Jul 1:e2000825. Epub 2020 Jul 1.

Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, 1111 Highland Ave., WIMR 5418, Madison, WI, 53705, USA.

There is a vital need to develop in vitro models of the developing human brain to recapitulate the biological effects that toxic compounds have on the brain. To model perineural vascular plexus (PNVP) in vitro, which is a key stage in embryonic development, human embryonic stem cells (hESC)-derived endothelial cells (ECs), neural progenitor cells, and microglia (MG) with primary pericytes (PCs) in synthetic hydrogels in a custom-designed microfluidics device are cocultured. The formation of a vascular plexus that includes networks of ECs (CD31+, VE-cadherin+), MG (IBA1+), and PCs (PDGFRβ+), and an overlying neuronal layer that includes differentiated neuronal cells (βIII Tubulin+, GFAP+) and radial glia (Nestin+, Notch2NL+), are characterized. Read More

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http://dx.doi.org/10.1002/adhm.202000825DOI Listing

InP Quantum Dots: Synthesis and Lighting Applications.

Small 2020 Jul 1:e2002454. Epub 2020 Jul 1.

Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR, China.

InP quantum dots (QDs) are typical III-V group semiconductor nanocrystals that feature large excitonic Bohr radius and high carrier mobility. The merits of InP QDs include large absorption coefficient, broad color tunability, and low toxicity, which render them promising alternatives to classic Cd/Pb-based QDs for applications in practical settings. Over the past two decades, the advances in wet-chemistry methods have enabled the synthesis of small-sized colloidal InP QDs with the assistance of organic ligands. Read More

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http://dx.doi.org/10.1002/smll.202002454DOI Listing

Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study.

Andrologia 2020 Jul 2:e13737. Epub 2020 Jul 2.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Considering dopamine-enhancing effect of (+)-catechin, the present study was designed to evaluate dopamine-2 (D2) receptor agonistic and phosphodiesterase-5 (PDE5) enzyme inhibitory effects in in silico and effect on male sexual function of Sprague Dawley rats in vivo. (+)-Catechin and standard (sildenafil and bromocriptine) were docked using Autodock Vina 1.1. Read More

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http://dx.doi.org/10.1111/and.13737DOI Listing

Genistein and Galantamine Combinations Decrease β-Amyloid Peptide -Induced Genotoxicity and Cell Death in SH-SY5Y Cell Line: an In Vitro and In Silico Approach for Mimic of Alzheimer's Disease.

Neurotox Res 2020 Jul 1. Epub 2020 Jul 1.

Department of Genetics, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14090-900, Brazil.

Alzheimer's disease (AD) is the primary dementia-causing disease worldwide, involving a multifactorial combination of environmental, genetic, and epigenetic factors, with essential participation of age and sex. Biochemically, AD is characterized by the presence of abnormal deposition of beta amyloid peptide (Aβ), which in the brain is strongly correlated with oxidative stress, inflammation, DNA damage, and cholinergic impairment. The multiple mechanisms involved in its etiology create significant difficulty in producing an effective treatment. Read More

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http://dx.doi.org/10.1007/s12640-020-00243-8DOI Listing

Repellence and fumigant toxicity of essential oils of Ocimum gratissimum and Ocimum kilimandscharicum on Tuta absoluta (Lepidoptera: Gelechiidae).

Environ Sci Pollut Res Int 2020 Jul 2. Epub 2020 Jul 2.

Chemistry Department, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya.

Tuta absoluta Meyrick originates in South America and is now one of the most important insect pests of Solanaceae in different parts of the world, including Africa. Its control has relied primarily on chemical insecticides, which are associated with negative ecological effects. In the present study, essential oils of Ocimum gratissimum and O. Read More

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http://dx.doi.org/10.1007/s11356-020-09773-2DOI Listing

Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach.

Biol Trace Elem Res 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, 25240, Erzurum, Turkey.

In this study, the protective effects of chrysin (CR) on lead acetate (PbAc)-induced renal toxicity in Sprague-Dawley rats were investigated with biochemical, histopathological, and immunohistochemical methods. In the study, rats were given orally at 30 mg/kg/body weight (BW) PbAc after CR of 25 and 50 mg/kg/BW was administered to them orally (a total of 7 administrations for 7 days). The results showed that CR reduced urea and creatinine levels by alleviating PbAc-induced kidney damage. Read More

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http://dx.doi.org/10.1007/s12011-020-02268-8DOI Listing

Gender Differences in the Effect of Calcitriol on the Body Disposition and Excretion of Doxorubicin in Mice.

Eur J Drug Metab Pharmacokinet 2020 Jul 1. Epub 2020 Jul 1.

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42031, Konya, Turkey.

Background And Objective: The antitumor activity and toxicity of doxorubicin are potentiated and attenuated by calcitriol, respectively. Potentially, calcitriol can be combined with doxorubicin for clinical benefit in chemotherapy. To gain insight into the interaction between doxorubicin and calcitriol, proposed for combined use in cancer treatment, we studied calcitriol's effect on the plasma pharmacokinetics, tissue distribution and excretion of doxorubicin in female and male mice. Read More

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http://dx.doi.org/10.1007/s13318-020-00632-6DOI Listing

[Prognostic and predictive methylation biomarkers in HNSCC : Epigenomic diagnostics for head and neck squamous cell carcinoma (HNSCC)].

HNO 2020 Jul 1. Epub 2020 Jul 1.

Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Background: Prognostic and predictive biomarkers for personalized treatment management in head and neck squamous cell carcinoma (HNSCC) are of great clinical interest.

Objective: DNA methylation is an epigenetic process involved in gene regulation and could be a source of potential prognostic and predictive biomarkers.

Methods: This study comprises literature research in PubMed and own studies. Read More

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http://dx.doi.org/10.1007/s00106-020-00902-4DOI Listing

Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma.

Int J Hematol 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyusyu University, Fukuoka, Japan.

Duvelisib is a novel dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ. This single-arm, multicenter phase I study investigated its safety, pharmacokinetics, and preliminary efficacy in Japanese patients with relapsed or refractory lymphoma. Duvelisib was administered orally twice daily at 25 mg in 28-day cycles. Read More

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http://dx.doi.org/10.1007/s12185-020-02929-3DOI Listing

Loss of ERAD bridging factor UBX2 modulates lipid metabolism and leads to ER stress-associated apoptosis during cadmium toxicity in Saccharomyces cerevisiae.

Curr Genet 2020 Jul 1. Epub 2020 Jul 1.

Biomembrane Lab, Department of Biochemistry, School of Life Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.

The endoplasmic reticulum (ER) stress potentially activates the unfolded protein response (UPR) and ER-associated protein degradation (ERAD) as quality-control mechanisms. During ERAD process, the ERAD adaptor protein Ubx2 serves as a bridging factor and transports the misfolded proteins from the ER to the cytosol for subsequent ubiquitylation and proteasomal degradation. Cadmium (Cd) is a toxic metal that initiates ER stress and has an impact on lipid homeostasis and this study focuses on the synergistic impact of Cd exposure and ERAD (using ubx2∆ strain). Read More

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http://dx.doi.org/10.1007/s00294-020-01090-yDOI Listing

Adverse event management in the TOURMALINE-MM3 study of post-transplant ixazomib maintenance in multiple myeloma.

Ann Hematol 2020 Jul 1. Epub 2020 Jul 1.

Hematology and Medical Oncology, Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

The phase 3, double-blind, placebo-controlled TOURMALINE-MM3 study (NCT02181413) demonstrated improved progression-free survival with ixazomib maintenance versus placebo post autologous stem cell transplant (ASCT) in multiple myeloma patients. We report additional safety data from TOURMALINE-MM3 to inform adverse event (AE) management recommendations. Patients were randomized 3:2 to receive ixazomib (n = 395) or placebo (n = 261) on days 1, 8, and 15 of 28-day cycles for ~ 2 years or until progressive disease/toxicity. Read More

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http://dx.doi.org/10.1007/s00277-020-04149-5DOI Listing

Insight into the structure-antibacterial activity of amino cation-based and acetate anion-based ionic liquids from computational interactions with the POPC phospholipid bilayer.

Phys Chem Chem Phys 2020 Jul 2. Epub 2020 Jul 2.

State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.

Investigations relevant to ionic liquids (ILs) as antibacterial agents have drawn considerable attention. However, the high cost and potential toxicity of ILs have severely limited their extensive applications, which has motivated researchers to design inexpensive and health-benign ILs. In this work, the interactions between the hydrated zwitterionic phospholipid (POPC) bilayer and a series of hypothetical amino cation-based and acetate anion-based ILs with different counterparts were investigated using molecular dynamics (MD) simulations to predict their antibacterial abilities. Read More

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http://dx.doi.org/10.1039/d0cp02353aDOI Listing

W.T.Aiton exhibits anti-nociceptive and anti-diarrheal effects in Albino mice and an in silico model.

Animal Model Exp Med 2020 Jun 8;3(2):169-181. Epub 2020 Jun 8.

Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh.

Background: () is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti-nociceptive and anti-diarrheal effects of a rhizome methanol extract (Me-RCR).

Methods: The analgesic effects of Me-RCR were assessed using acetic acid-induced writhing and the formalin-induced flicking test. Read More

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http://dx.doi.org/10.1002/ame2.12119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323701PMC

Transgenic T-cell receptor immunotherapy for cancer: building on clinical success.

Ther Adv Vaccines Immunother 2020 22;8:2515135520933509. Epub 2020 Jun 22.

Immetacyte Ltd., University of Manchester, Manchester, Greater Manchester, UK.

With the advent of immunotherapy as a realistic and promising option for cancer treatment, adoptive cellular therapies are gaining significant interest in the clinic. Whilst the recent successes of chimeric antigen receptor T-cell therapies for haematological malignancies are widely known, they have yet to show great success in solid cancers. However, immune cells transduced with T-cell receptors have been shown to traffic to and exert anti-cancer effects on solid tumour cells with some great successes. Read More

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http://dx.doi.org/10.1177/2515135520933509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309387PMC

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis.

Heliyon 2020 Jun 20;6(6):e04248. Epub 2020 Jun 20.

Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.

Background: Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322251PMC

Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate.

Front Pediatr 2020 16;8:307. Epub 2020 Jun 16.

Department of Oncology and Hematology, University Children's Hospital, Kraków, Poland.

High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway. The aim of the current study is to determine the relationship between variants of folate metabolism-related genes and the frequency of acute toxicities of HD-Mtx. Read More

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http://dx.doi.org/10.3389/fped.2020.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308427PMC

Emerging and experimental treatments for COVID-19 and drug interactions with psychotropic agents.

Ther Adv Psychopharmacol 2020 22;10:2045125320935306. Epub 2020 Jun 22.

South London and Maudsley NHS Foundation Trust, London, UK.

As yet, no agents have been approved for the treatment of COVID-19, although several experimental drugs are being used off licence. These may have serious adverse effects and potential drug interactions with psychotropic agents. We reviewed the common agents being used across the world for the treatment of COVID-19 and investigated their drug interaction potential with psychotropic agents using several drug interaction databases and resources. Read More

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http://dx.doi.org/10.1177/2045125320935306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309390PMC

Prolonged efficacy of pembrolizumab in a patient presenting a multi-treated metastatic hepatocholangiocarcinoma.

Therap Adv Gastroenterol 2020 20;13:1756284820935189. Epub 2020 Jun 20.

Medical Oncology Department, Centre Antoine Lacassagne, Nice, France.

Introduction: Hepatocholangiocarcinoma (HCC-ICC) is a rare tumor presenting the histologic characteristics of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). As there is no consensus on it management, the therapeutic strategy rests on the specific treatments for HCC or ICC. Programmed cell death 1 (PD-1) inhibitors showed encouraging results in the second line treatment of HCC after sorafenib but it efficacy in HCC-ICC has never been reported. Read More

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http://dx.doi.org/10.1177/1756284820935189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307284PMC
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