Search Our Scientific Publications & Authors

Mol Ther Nucleic Acids 2019 Mar 28;16:378-390. Epub 2019 Mar 28.

Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; The Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:

Successful gene therapy requires the development of suitable carriers for the selective and efficient delivery of genes to specific target cells, with minimal toxicity. In this work, we present a non-viral vector for gene delivery composed of biocompatible materials, CaCl, plasmid DNA and the semi-synthetic anionic biopolymer alginate sulfate (AlgS), which spontaneously co-assembled to form nanoparticles (NPs). The NPs were characterized with a slightly anionic surface charge (Zeta potential [ζ] = -14 mV), an average size of 270 nm, and their suspension was stable for several days with no aggregation. Read More

Colloids Surf B Biointerfaces 2019 Mar 29;179:421-428. Epub 2019 Mar 29.

Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.

Combination therapy remains a promising approach to ameliorate cerebral ischemia injury. Nevertheless, the primary mechanism of the neuroprotective properties of Dictyopteris divaricata extract-capped gold nanoparticles (DD-GNPs) is not completely understood. DD-GNPs displayed maximum absorption at 525 nm and a diameter of 62. Read More

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

Environ Pollut 2019 Apr 10;250:331-337. Epub 2019 Apr 10.

Department F.-A. Forel for Environmental and Aquatic Sciences, Earth and Environmental Sciences, Faculty of Sciences, University of Geneva, 66, Boulevard Carl-Vogt, CH-1211, Geneva 4, Switzerland. Electronic address:

Microalgae are widely used as representative primary producers in ecotoxicology, while macrophytes are much less studied. Here we compared the bioavailability and cellular toxicity pathways of 2 h-exposure to 10 mol L Cu in the macrophyte Elodea nuttallii and the green microalga Chlamydomonas reinhardtii. Uptake rate was similar but faster in the algae than in the macrophyte, while RNA-Sequencing revealed a similar number of regulated genes. Read More

Biomed Pharmacother 2019 Apr 16;114:108855. Epub 2019 Apr 16.

Dept. of Biophysics, Bose Institute, P 1/12, CIT Scheme VII M, Kolkata, 700 054, WB, India; Dept. of Chemistry, Institute of Applied Science & Humanities GLA University Mathura, 17km Stone, NH-2, Mathura-Delhi Road, Mathura, 281 406, UP, India. Electronic address:

The anti-carcinogenic effect of Methylglyoxal (MG) is well established. It generally targets malignant cells by affecting glycolysis and mitochondrial respiration with minimum or no toxicity to normal cells. In an initial study we have reported that MG can synergistically act with 5-Fluorouracil (5-FU) to decreases the number of MCF-7 breast cancer cells (Ghosh S, Pal A, Ray M, 2017). Read More

Chemosphere 2019 Apr 10;227:480-488. Epub 2019 Apr 10.

Universidad San Jorge, Campus Universitario, Autov A23 Km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The increasing interest in the development of ecofriendly solvents has led to the synthesis of benign alternative chemicals with minimized environmental impacts. These kinds of chemicals are known as Green solvents. In this work, we selected three families of solvents (furfural, lactate and levulinate families) derived from biomass that are structurally related. Read More

Chemosphere 2019 Apr 13;227:444-454. Epub 2019 Apr 13.

Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B3; Department of Soil Science, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5A8.

Soil habitat quality is thought to influence metal toxicity via changes in speciation and thereby toxicokinetics. Here, we assessed the toxicokinetic and toxicodynamic effects of habitat quality on mite, Oppia nitens when exposed to zinc (Zn) contaminated soils. Forty-seven soils were ranked into three habitat qualities; high, medium, and low based on biological reproduction of Folsomia candida, Enchytraeus crypticus, and Elymus lanceolatus. Read More

Chemosphere 2019 Apr 13;227:425-434. Epub 2019 Apr 13.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

Pesticide pollution residues have become increasingly common health hazards over the last several decades because of the wide use of pesticides. The gastrointestinal tract is the first physical and biological barrier to contaminated food and is therefore the first exposure site. Interestingly, a number of studies have shown that the gut microbiota plays a key role in the toxicity of pesticides and has a profound relationship with environmental animal and human health. Read More

Chemosphere 2019 Apr 12;227:389-400. Epub 2019 Apr 12.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515, Guangzhou, China. Electronic address:

Polychlorinated biphenyls (PCBs), a kind of persistent organic pollutant, can induce hepatotoxicity in mammals. However, PCB-induced hepatotoxicity in offspring and the underlying mechanisms have been rarely studied. In the present study, Wistar rats were administered with corn oil or PCB52 (1 mg/kg body weight/day, by gavage) from gestational day 7 to postnatal day 21. Read More

J Hazard Mater 2019 Apr 5;374:203-210. Epub 2019 Apr 5.

Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares (Madrid), Spain; Instituto de Investigación Química Andrés M. del Río, Universidad de Alcalá, Ctra, Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares (Madrid), Spain. Electronic address:

Stability and toxicity studies for duloxetine and econazole were achieved using individual solutions and their mixtures. Stability of drugs racemates and enantiomers was investigated under abiotic and biotic conditions. Toxicity was evaluated for the first time on Spirodela polyrhiza. Read More

Sci Total Environ 2019 Mar 25;673:726-733. Epub 2019 Mar 25.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address:

As a typical nanomaterial, graphene oxide (GO) can be easily dispersed in water and may affect the aqueous environment. In this paper, the degradation of triclosan (TCS) in a Fenton-like system Fe/HO in GO aqueous solution was investigated. Interestingly, it was observed that GO at low concentration (2. Read More

Biomed Pharmacother 2019 Apr 16;115:108873. Epub 2019 Apr 16.

Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil; Postgraduate Program in Pharmaceutical Sciences, Laboratory of Genetic Toxicology, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil.

Gingerol - [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; [6]-G) - is a phenolic compound with several pharmacological properties. Herein, the aim of the study was to evaluate the toxicogenic effects of [6]-G on Artemia salina nauplii, Allium cepa, HL-60 cell line and Sarcoma 180 (S-180) ascitic fluid cells.For toxic and genotoxic analysis, it was used [6]-G concentrations of 5, 10, 20 and 40 μg mL-1. Read More

Aquat Toxicol 2019 Mar 25;211:181-192. Epub 2019 Mar 25.

Departamento de Biologia & CESAM, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Inappropriate processing and disposal of electronic waste contributes to the contamination of aquatic systems by various types of pollutants such as the rare-earth elements (REE) in which lanthanum (La) is included. Knowledge on the toxicity of these elements in marine organisms is still scarce when compared to other metals such as mercury (Hg) and arsenic (As). Therefore, this study aims to assess the toxicity of La on the mussel Mytilus galloprovincialis, considered a good bioindicator of aquatic pollution, through the analysis of metabolic, oxidative stress, neurotoxicity and histopathological markers. Read More

Toxicol In Vitro 2019 Apr 16. Epub 2019 Apr 16.

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL - Italian Workers' Compensation Authority, Monte Porzio Catone, Rome, Italy.

Biosoluble AES wools are increasingly used since considered not hazardous, however, few toxicity studies are available. We evaluated cytotoxic, genotoxic-oxidative and inflammatory effects of two differently soluble AES wools, AES1 (high MgO percentage) and AES2 (high CaO percentage), on alveolar (A549) and bronchial (BEAS-2B) cells. Fiber dimensions and dissolution in cell media were evaluated by SEM analysis. Read More

Int J Radiat Oncol Biol Phys 2019 Apr 16. Epub 2019 Apr 16.

Sunnybrook Odette Centre; Department of Radiation Oncology, University of Toronto. Electronic address:

Purpose: HDR brachytherapy boost plus external beam radiotherapy is an established option for intermediate risk prostate cancer (PCa). SBRT boost can potentially mimic HDR boost, and could be a viable alternative. Here we report the long-term outcomes of a phase I dose-escalation trial of single-fraction SBRT boost. Read More

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address:

Liposomal anticancer drugs have been developed with improved clinical effects and reduced side effects. We have developed a PEGylated liposomal formulation of oxaliplatin that has anticancer effects in animal models of colorectal cancer with a favorable toxicity profile. To move this formulation into clinical development, a formulation that is stable during long term storage is needed, which has similar pharmacokinetics and therapeutic activity against solid tumors to the original formulation. Read More

Biochim Biophys Acta Biomembr 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra 400076, India. Electronic address:

Lipid structure critically dictates the molecular interactions of drugs with membranes influencing passive diffusion, drug partitioning and accumulation, thereby underpinning a lipid-composition specific interplay. Spurring selective passive drug diffusion and uptake through membranes is an obvious solution to combat growing antibiotic resistance with minimized toxicities. However, the spectrum of complex mycobacterial lipids and lack thereof of suitable membrane platforms limits the understanding of mechanisms underlying drug-membrane interactions in tuberculosis. Read More

J Phys Chem Lett 2019 Apr 19. Epub 2019 Apr 19.

Development of technologies for protection against chemical warfare agents (CWAs) is critically important. Recently, polyoxometalates have attracted attention as potential catalysts for nerve-agent decomposition. The improvement of their effectiveness in real operating conditions requires an atomic-level understanding of CWA decomposition at the gas-solid interface. Read More

PLoS One 2019 19;14(4):e0214219. Epub 2019 Apr 19.

Technical University of Berlin (TUB), Institute of Applied Geosciences, Berlin, Germany.

Selenium plays an important, but vastly neglected role in human nutrition with a narrow gap between dietary deficiency and toxicity. For a potential biofortification of food with Se, as well as for toxicity-risk assessment in sites contaminated by Se, modelling of local and global Se cycling is essential. As bioavailability of Se for rice plants depends on the speciation of Se and the resulting interactions with mineral surfaces as well as the interaction with Se uptake mechanisms in plants, resulting plant Se content is complex to model. Read More

Rambam Maimonides Med J 2019 Apr 18;10(2). Epub 2019 Apr 18.

Department of Cardiology, Rambam Health Care Campus, Haifa, Israel.

Chemotherapy-associated myocardial toxicity is increasingly recognized with the expanding armamentarium of novel chemotherapeutic agents. The onset of cardiotoxicity during cancer therapy represents a major concern and often involves clinical uncertainties and complex therapeutic decisions, reflecting a compromise between potential benefits and harm. Furthermore, the improved cancer survival has led to cardiovascular complications becoming clinically relevant, potentially contributing to premature morbidity and mortality among cancer survivors. Read More

Int J Med Mushrooms 2019 ;21(4):401-411

College of Veterinary Medicine, National Chung Hsing University, Taichung City, Taiwan.

Recently, erinacine A-enriched Hericium erinaceus (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease. Despite promising results from animal models, there have been no reports on its toxicity after long-term consumption. Hence, the present study was designed to evaluate the safety of EAHE mycelia through a 13-week subchronic rodent feeding study. Read More

Crit Rev Eukaryot Gene Expr 2019 ;29(1):29-36

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Gene therapy has attracted considerable attention for the treatment of genetic and acquired diseases. Successful gene therapy occurs when the therapeutic genes penetrate targeted cells and become available to the intracellular active site. Currently, a promising approach in gene delivery is the use of nonviral gene delivery vectors that lack immunogenicity but have low toxicity and potential tissue specificity. Read More

J Med Chem 2019 Apr 19. Epub 2019 Apr 19.

As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin and 5-fluorouracil are widely used in clinic, but limited by severe side-effects. To ameliorate their respective defects, a series of "dual-prodrug" by linking oxoplatin and 5-FU, were designed and synthesized. The assembled compounds 10-17, named Fuplatin, exhibited much higher cytotoxicity against the tested cancer cells while lower toward the human normal lung cells than free drugs or their combinations. Read More

ACS Appl Mater Interfaces 2019 Apr 19. Epub 2019 Apr 19.

Nanomedicine has emerged as a promising strategy for effective cancer treatment. A useful approach is to develop carrier-free nanodrugs via facile supramolecular self-assembly process. To achieve high therapeutic effect, integrating photodynamic therapy with chemotherapy has been sought after. Read More

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

Unid Reabilit Cardiovasc e Fisiol do Exerc, Heart Institute (InCor), University of Sao Paulo Medical School and School of Physical Education and Sport, University of Sao Paulo, Brazil.

Aims: To test if doxorubicin (DX) and cyclophosphamide (CY) adjuvant chemotherapy (CHT) acutely impairs neurovascular and hemodynamic responses in women with breast cancer.

Methods: Sixteen women (age:47.0±2. Read More

Mol Pharm 2019 Apr 19. Epub 2019 Apr 19.

nab-Paclitaxel ( nab-P), an albumin-bound formulation of paclitaxel, was developed to improve the tolerability and antitumor activity of taxanes. The neonatal Fc receptor (FcRn) is a transport protein that can bind to albumin and regulate the homeostasis of circulating albumin. Therefore, the pharmacokinetics and pharmacodynamics of nab-P may be impacted by FcRn expression. Read More

Anal Chem 2019 Apr 19. Epub 2019 Apr 19.

Nanoscale particles are ubiquitous in the atmosphere, and the widespread use of nanoparticles may increase the risks of organ damage. Therefore, it is of great significance to investigate the toxicity of nanoparticles of different sizes toward living cells, especially lung epithelial cells. In this study, the quantitative ratiometric fluorescent detection of intracellular pH changes was utilized to evaluate the cytotoxicity of mesoporous silica nanoparticles of different sizes after the nanoparticles had entered lung epithelial cells. Read More

Cell Physiol Biochem 2019 ;52(5):1203-1222

Department of Zoology, Bharathiar University, Coimbatore, India.

Background/aims: Agriculture and industrial expansion in recent years have resulted in the undue discharge of arsenic into the environment, building arsenic toxicity a major worldwide anxiety. Oxidative stress is considered as the most conspicuous effect of arsenic toxicity. The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway. Read More

Probiotics Antimicrob Proteins 2019 Apr 18. Epub 2019 Apr 18.

Biochemistry Department, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.

Peptides are considered very important due to the diversity expressed through their amino acid sequence, structure variation, large spectrum, and their essential role in biological systems. Antimicrobial peptides (AMPs) emerged as a potent tool in therapy owing to their antimicrobial properties but also their ability to trespass the membranes, specificity, and low toxicity. They comprise a variety of peptides from which specific amino acid-rich peptides are of interest to the current review due to their features in metal interaction and cell penetration. Read More

Environ Sci Pollut Res Int 2019 Apr 19. Epub 2019 Apr 19.

College of Resources and Environment, Hunan Agricultural University, Changsha, 410128, People's Republic of China.

Heavy metal pollution, in particular with cadmium (Cd), threatens both the environment and human health. The phytoremediation of contaminated soil is one recently developed eco-friendly technique that can be applied to mitigate this issue. Repairing Cd-contaminated paddy soil during the fallow winter period can ensure future rice production while reducing heavy metal pollution. Read More

Environ Sci Pollut Res Int 2019 Apr 18. Epub 2019 Apr 18.

Department of Zoology, Khalsa College, Amritsar, Punjab, 143002, India.

High contents of azo dyes and heavy metals enter surface waters with the wastewater from dying and dye-manufacturing industries and pose serious threat to fish. In the present study, changes in the ultra-morphological features of the scale have been evaluated as indicators of the stress of lethal and sublethal concentrations of an azo dye Acid Black-1 (AB-1, CI 20470), zinc (Zn), and their mixture AB-1 + Zn to Labeo rohita. Fish were exposed for 96 h to lethal concentration (LC) causing 0-70% mortality, i. Read More

Environ Sci Pollut Res Int 2019 Apr 18. Epub 2019 Apr 18.

Australian Rivers Institute, School of Environment and Science, Griffith University, Southport, QLD, 4222, Australia.

Concerns regarding disinfection by-product (DBP) formation during drinking water treatment have led water utilities to apply treatment processes to reduce the concentration of DBP precursor natural organic matter (NOM). However, these processes often do not remove bromide, leading to high bromide to dissolved organic carbon (DOC) ratios after treatment, which can increase the formation of more toxic brominated DBPs. In the current study, we investigated the formation and effect of DBPs in a matrix of synthetic water samples containing different concentrations of bromide and DOC after disinfection with chlorine. Read More

Fish Physiol Biochem 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Biologia/CESAM, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.

The presence of pharmaceutical residues in the aquatic environment is receiving great attention since the levels of these substances have significantly increased in this compartment, potentially leading to adverse ecological effects. Zinc pyrithione (ZnPt) is a widely used organometallic biocide, which is incorporated into antifouling formulas, such as paints, to prevent the establishment of biofilms on surfaces exposed to the aquatic environment. It is also used in cosmetics, such as antidandruff shampoos and soaps. Read More

Drug Deliv Transl Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

The present work aimed to prepare silymarin-loaded mesoporous silica nanoparticles (MSNs) and to assess the system's dissolution enhancement ability on the pharmacodynamic performance of silymarin as a hepatoprotective agent. For this purpose, a soft-templating technique was used to prepare silymarin-loaded MSNs. The loaded MSNs were further characterized for their particle size, zeta potential, surface properties, and in vitro drug dissolution testing. Read More

Exp Appl Acarol 2019 Apr 19. Epub 2019 Apr 19.

Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites have been suggested to have a role in various cutaneous and ocular disorders pathogenesis, such as rosacea or blepharitis. Evaluation of potential treatments with anti-Demodex effects is difficult because the viability of living mites needs to be evaluated during their exposure to the agent being tested. Mite viability is currently based solely on their observed movement. Read More

Front Mol Biosci 2019 3;6:20. Epub 2019 Apr 3.

Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Increasing evidence in recent years indicates that protein misfolding and aggregation, leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases. This is particularly true in Huntington's disease (HD), where in contrast with other disorders, the cause is monogenic. Mutant huntingtin interferes with many cellular processes, but the fact that modulation of ER stress and of the unfolded response pathways reduces the toxicity, places these mechanisms at the core and gives hope for potential therapeutic approaches. Read More

Front Bioeng Biotechnol 2019 2;7:72. Epub 2019 Apr 2.

Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zürich, Zurich, Switzerland.

screening methods for compound efficacy and toxicity to date mostly include cell or tissue exposure to preset constant compound concentrations over a defined testing period. Such concentration profiles, however, do not represent realistic situations after substance uptake. Absorption, distribution, metabolism and excretion of administered substances in an organism or human body entail gradually changing pharmacokinetic concentration profiles. Read More

Front Oncol 2019 2;9:217. Epub 2019 Apr 2.

Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia.

To report feasibility, early toxicity, and PSA kinetics following gantry-based, stereotactic radiotherapy (SBRT) boost within a prospective, phase 2, multicenter study (PROMETHEUS: ACTRN12615000223538). Patients were treated with gantry-based SBRT, 19-20 Gy in two fractions delivered 1 week apart, followed by conventionally fractionated IMRT (46 Gy in 23 fractions). The study mandated MRI fusion for RT planning, rectal displacement, and intrafraction image guidance. Read More

Oxid Med Cell Longev 2019 14;2019:3782074. Epub 2019 Mar 14.

High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.

Radiotherapy is effective on a large number of cancer types and is one of the most frequently administrated treatments for cancer patients. The anticancer efficacy of X-ray radiotherapy has been frequently correlated with reactive oxygen species (ROS) elevation, which is also a limiting factor for its toxicity on normal tissues. Here, we found that although 4-10 Gy X-rays could significantly reduce cell numbers in both MDA-MB-231 and MCF-7 breast cancer cells, the ROS level changes are less in MCF-7 cells than in MDA-MB-231 cells. Read More

Evid Based Complement Alternat Med 2019 13;2019:8920813. Epub 2019 Mar 13.

Department of Chinese Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Autophagy plays an important role in the development of Parkinson disease (PD). Previous studies showed that autophagy could protect cells from -synuclein toxicity and promote functional coupling of mitochondria. But it is still a question whether modulating autophagy can be used to treat PD. Read More

Front Plant Sci 2019 2;10:367. Epub 2019 Apr 2.

Department of Forest and Soil Sciences, Institute of Soil Research, University of Natural Resources and Life Sciences Vienna, Tulln, Austria.

Tungsten (W) finds increasing application in military, aviation and household appliance industry, opening new paths into the environment. Since W shares certain chemical properties with the essential plant micronutrient molybdenum (Mo), it is proposed to inhibit enzymatic activity of molybdoenzymes [e.g. Read More

Front Immunol 2019 2;10:651. Epub 2019 Apr 2.

Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam UMC, Amsterdam, Netherlands.

CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors. Read More

Front Microbiol 2019 2;10:622. Epub 2019 Apr 2.

Department of Food Hygiene and Technology, Universidad de León, León, Spain.

Non-thermal Atmospheric Plasma (NTAP) is a cutting-edge technology which has gained much attention during the last decade in the food-processing sector as a promising technology for food preservation and maintenance of food safety, with minimal impact on the quality attributes of foods, thanks to its effectiveness in microbial inactivation, including of pathogens, spoilage fungi and bacterial spores, simple design, ease of use, cost-effective operation, short treatment times, lack of toxic effects, and significant reduction of water consumption. This review article provides a general overview of the principles of operation and applications of NTAP in the agri-food sector. In particular, the numerous studies carried out in the last decade aimed at deciphering the influence of different environmental factors and processing parameters on the microbial inactivation attained are discussed. Read More

Front Physiol 2019 3;10:377. Epub 2019 Apr 3.

College of Animal Science, Zhejiang University, Hangzhou, China.

Widespread applications of cadmium (Cd) in various products have caused Cd contamination in marine ecosystems. Meanwhile, human activities in the ocean have also generated an increasing amount of noise in recent decades. Although anthropogenic noise and Cd contaminants could be present simultaneously in marine environments, the physiological responses of marine bivalve mollusks upon coexposure to anthropogenic noise and toxic metal contaminants, including Cd remain unclear. Read More

Front Pharmacol 2019 2;10:319. Epub 2019 Apr 2.

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the anticancer effect of Zn-CuO NPs on human pancreatic cancer cells. Read More

Front Pharmacol 2019 29;10:285. Epub 2019 Mar 29.

School of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.

The first-line chemotherapy drug adriamycin (ADM) is widely used for the treatment of breast cancer, but the acquired drug resistance and the normal tissue toxicity remain clinical challenges. Alteronol has been reported to exert wide-ranging anti-tumor activity. In this study, we firstly examined the synergistic anti-tumor effects and the underlying mechanisms of alteronol combined with ADM in breast cancer. Read More

Lab Anim (NY) 2019 May;48(5):142

Lab Animal, .

Acta Pharmacol Sin 2019 Apr 18. Epub 2019 Apr 18.

College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, China.

Excessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer. Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis. Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential drugs for cancer treatment. Read More

Clin Genitourin Cancer 2019 Mar 27. Epub 2019 Mar 27.

Northampton General Hospital NHS Trust, Cliftonville, Northampton, United Kingdom.

Background: Elderly metastatic renal cell carcinoma (mRCC) patients are under-represented in clinical trials, whose results are therefore difficult to translate into routine management of older patients. We aimed at exploring treatment outcomes and prognostic factors in our real-life elderly mRCC cohort receiving first-line tyrosine kinase inhibitor (TKI) monotherapy.

Patients And Methods: We retrospectively analyzed demographic and clinicopathological characteristics, and treatment data of elderly (≥ 70 years old at first-line start) mRCC patients starting either pazopanib or sunitinib as first-line treatment in our institution between March 2012 and April 2018. Read More