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J Biomed Mater Res A 2020 Jul 12. Epub 2020 Jul 12.

Department of Chemistry, University of North Carolina at Chapel Hill, B 3290, Chapel Hill, North Carolina.

The prevalence of periodontal disease poses a significant global health burden. Treatments for these diseases, primarily focused on removal and eradication of dental plaque biofilms, are challenging due to limited access to periodontal pockets where these oral pathogens reside. Herein, we report on the development and characterization of nitric oxide (NO)-releasing carboxymethylcellulose (CMC) derivatives and evaluate their in vitro bactericidal efficacy against planktonic Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, two prominent periodontopathogens. Read More

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Department of Urology, Urology and Nephrology Center, Mansoura University, Egypt.

Objectives: To study the efficacy of low energy shock wave (LESW) on enhancing intravesical epirubicin (EPI) delivery in a rat model of bladder cancer (BC).

Materials And Methods: 100 female Fischer rats were randomly allocated into five groups; Control, BC, LESW, EPI and EPI plus LESW groups. After BC induction by N-butyl-N-(4-hydroxybutyl)nitrosamine, EPI (0. Read More

Med Phys 2020 Jul 12. Epub 2020 Jul 12.

Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.

Purpose: Segmentation of organs-at-risk (OARs) is a weak link in radiotherapeutic treatment planning process because the manual contouring action is labor-intensive and time-consuming. This work aimed to develop a deep learning-based method for rapid and accurate pancreatic multi-organ segmentation that can expedite the treatment planning process.

Methods: We retrospectively investigated one hundred patients with CT simulation scanned and contours delineated. Read More

Bull Exp Biol Med 2020 Jul 11. Epub 2020 Jul 11.

A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia.

Exposure of male Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) for 4 h resulted in significant, transient, and reversible decrease in hemolytic resistance of peripheral blood erythrocytes. Read More

Mycotoxin Res 2020 Jul 11. Epub 2020 Jul 11.

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, Zagreb, 10000, Croatia.

Ochratoxin A (OTA) and citrinin (CIT) are mycotoxins known to co-contaminate human/animal food/feed. Their prominent nephrotoxic effects pose a threat to human and animal health. Studies have shown synergistic or additive effects of these two mycotoxins, but a clear consensus on this phenomenon does not exist. Read More

Naunyn Schmiedebergs Arch Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, 64049-550, Brazil.

The compound (+)-limonene epoxide has antioxidant, anxiolytic, and antihelminthic properties. However, investigations to determine its long-term exposure were not performed. We investigated the systemic toxicological profile after chronic exposure as well as the antidepressant and antiepileptic potentialities of (+)-limonene epoxide on mice. Read More

Support Care Cancer 2020 Jul 11. Epub 2020 Jul 11.

Population Health Sciences Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK.

Purpose: Financial toxicity related to cancer diagnosis and treatment is a common issue in developed countries. We seek to systematically summarize the extent of the issue in very high development index countries with publicly funded healthcare.

Methods: We identified articles published Jan 1, 2005, to March 7, 2019, describing financial burden/toxicity experienced by cancer patients and/or informal caregivers using OVID Medline Embase and PsychInfo, CINAHL, Business Source Complete, and EconLit databases. Read More

Environ Int 2020 Jul 9;143:105900. Epub 2020 Jul 9.

Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, China; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China. Electronic address:

Background: Human are widely exposed to multiple metals, some of which have suspected reproductive toxicity, but no human studies have investigated the developmental effects of prenatal metal exposure.

Objectives: We aimed to evaluate the associations between prenatal multiple metal exposure and reproductive development in boys at 2-3 years using multi-pollutant approach.

Methods: This prospective study used data of 564 mother-child pairs recruited from the Guangxi Birth Cohort Study. Read More

J Hazard Mater 2020 Jul 4;401:123395. Epub 2020 Jul 4.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, China.

A visible light self-powered photoelectrochemical (PEC) aptasensor based on silver chromate particles, graphitic carbon nitride nanosheets and graphene oxide sheets (AgCrO/g-CN/GO) for the ultrasensitive detection of chloramphenicol (CAP) was reported in this work. g-CN was considered to be the fundamental photoelectric material because of its great oxidation ability of photogenerated hole as well as excellent biocompatibility and low toxicity. However, the narrow light absorption range and rapid carrier recombination rate limit the application of pure g-CN. Read More

J Hazard Mater 2020 Jul 4;401:123388. Epub 2020 Jul 4.

Microelement Research Center, College of Resources and Environment, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China. Electronic address:

Boron (B) is indispensable for plant growth and has been reported in the mitigation of aluminum (Al) toxicity in different plants. This study focused on the efficacy of B in reducing Al toxicity to trifoliate orange seedlings in a hydroponic experiment. Boron supply had a positive effect on root length and plant growth-related parameters and attenuated Al-induced inhibition of plasma membrane H-ATPase activity. Read More

J Hazard Mater 2020 Jul 2;401:123368. Epub 2020 Jul 2.

Plant Omics Division, CSIR- Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Gijubhai Badheka Marg, Bhavnagar, 364002, Gujarat, India; Academy of Scientific and Innovative Research, CSIR- Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar, 364002, Gujarat, India. Electronic address:

Heavy metal(loid)s contamination in soil is a major environmental concern that limits agricultural yield and threatens human health worldwide. Arsenic (As) is the most toxic non-essential metalloid found in soil which comes from various natural as well as human activities. S. Read More

J Hazard Mater 2020 Jun 30;401:123341. Epub 2020 Jun 30.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Halogenated flame retardants (HFRs), including Tetrabromobisphenol A (TBBPA), Tetrabromobisphenol S (TBBPS), and Tetrachlorobisphenol A (TCBPA), are widely applied in the manufacturing industry to improve fire safety and can be detected in pregnant women's serum at nanomolar levels. Thus, it is necessary to pay attention to the three HFR potential development toxicity, which has not been conclusively addressed yet. The liver is the main organ that detoxifies our body; TBBPA exposure may lead to increased liver weight in rodents. Read More

J Hazard Mater 2020 Jun 28;401:123333. Epub 2020 Jun 28.

Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:

Phytoremediation is considered to be a cost-effective strategy for removing boron (B) from polluted water. In this study, Myriophyllum elatinoides, a widespread submerged or floating macrophyte, was found to survive in 40 mg B/L. Time-dependent kinetics show that the shoot exhibits a much longer period of B uptake and a much higher maximal tissue B concentration than the root. Read More

Environ Pollut 2020 Jul 3;266(Pt 1):114994. Epub 2020 Jul 3.

School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address:

Very little is currently known regarding the effects of estrogenic endocrine disrupting chemicals on embryonic and larval development in molluscs, nor the potential effects of parental (F) exposure on resultant F offspring. In this study, we assessed the embryotoxic impacts of exposure to environmentally relevant concentrations of the synthetic estrogen, 17α-ethinylestradiol (EE2), to male and female parents (50 ng/L) and their offspring (5 and 50 ng/L) in the native Australian Sydney rock oyster, Saccostrea glomerata. There were no detectable effects of parental exposure on fertilisation success, proportions of early larval (F) morphs and unfertilised eggs. Read More

Sci Total Environ 2020 Jul 1;743:140658. Epub 2020 Jul 1.

Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Sydney, NWS 2007, Australia.

This study aims to investigate the environmental issues regarding the construction phase of the wastewater treatment plant (WWTP) and explore the roles of different materials through their environmental impacts. Detailed inventories of the two WWTPs were conducted by involving materials and transportation for civil works undertaken. EPD 2018 and ReCiPe life cycle impact assessment methods were employed to measure all the impact categories. Read More

Sci Total Environ 2020 Jul 3;743:140627. Epub 2020 Jul 3.

Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.

Neonicotinoid insecticides pose risks that need to be managed for conservation of aquatic ecosystems. In this study, we evaluated the associations between the estimated environmental concentrations of two neonicotinoid insecticides (imidacloprid and dinotefuran) and the total abundances of seven functional feeding groups (FFGs) of benthic invertebrate communities in rivers in urban rice-paddy areas in four Japanese regions. Regional datasets of benthic invertebrate communities and environmental variables available for Japan were analyzed. Read More

Neurobiol Dis 2020 Jul 9:105013. Epub 2020 Jul 9.

Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, Hunan, China; Hunan Key Laboratory of Medical Genetics, Central South University, Changsha 410078, Hunan, China; Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha 410078, Hunan, China. Electronic address:

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by expansion of CGG repeats in the 5' UTR of the fragile X mental retardation 1 (FMR1) gene. Using the well-established FXTAS Drosophila model, we performed a high-throughput chemical screen using 3200 small molecules. NSC363998 was identified to suppress the neurodegeneration caused by riboCGG (rCGG) repeats. Read More

Clin Microbiol Infect 2020 Jul 9. Epub 2020 Jul 9.

Department of Infectious Diseases and General Internal Medicine, University Hospital of Liège, Liège, Belgium.

Objectives: Neurotoxicity related to cefepime is increasingly reported in the literature but specific data concerning continuous infusion (CI) of the drug are still lacking. Our primary objective was to evaluate the incidence of neurotoxicity related to CI of cefepime and the associated risk factors. Our secondary objectives were to analyze the plasma cefepime concentrations and to define the threshold above which neurotoxicity occurs. Read More

Bioorg Chem 2020 Jul 2;102:104056. Epub 2020 Jul 2.

São Paulo State University (UNESP), Institute of Biosciences, São Vicente, Praça Infante Dom Henrique, s/n, 11330-900 São Vicente, SP, Brazil; São Paulo State University (UNESP), Institute for Advanced Studies of Ocean, São Vicente, Av. João Francisco Bensdorp, 1178, 11350-011 São Vicente, SP, Brazil. Electronic address:

Leishmaniasis is an infectious disease caused by protozoan parasites of the genus Leishmania. The treatment of all forms of leishmaniasis relies on first-line drug, pentavalent antimonial, and in cases of drug failure, the second-line drug amphotericin B has been used. Besides the high toxicity of drugs, parasites can be resistant to antimonial in some areas of the World, making it necessary to perform further studies for the characterization of new antileishmanial agents. Read More

J Control Release 2020 Jul 9. Epub 2020 Jul 9.

Institute of Pharmacy and Food Chemistry, University of Würzburg, DE-97074 Würzburg, Germany. Electronic address:

Anti-inflammatory cytokines are a promising class of therapeutics for treatment of rheumatoid arthritis (RA), but their use is currently limited by a rapid clearance and systemic toxicity. Interleukin-4 is a small cytokine with potential for RA therapy. To increase its pharmacokinetic features, we engineered a murine IL4 conjugate by incorporating an unnatural amino acid through genetic code expansion to which PEG-folate, as a targeting moiety and PEG alone as control, were site-specifically bound. Read More

Exp Cell Res 2020 Jul 9:112168. Epub 2020 Jul 9.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address:

Pharmacologic induction of fetal hemoglobin (HbF) is an effective strategy for treating β-hemoglobinopathies like β-thalassemia and sickle cell anemia by ameliorating disease severity. Hydroxyurea is the only FDA-approved agent that induces HbF, but significant nonresponders and toxicity limit its clinical usefulness. This study relates preclinical investigation of Tenofovir disoproxil fumarate (TDF) as a potential HbF inducing agent, using human erythroleukemia cell line and a β-YAC mouse model. Read More

Toxicol In Vitro 2020 Jul 9:104934. Epub 2020 Jul 9.

Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu 610041, Sichuan, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:

Etomidate is a sedative-hypnotic with excellent pharmacological effects, including rapid onset and hemodynamic stability. However, etomidate causes adrenocortical toxicity via binding to 11β-hydroxylase. Therefore, developing an approach to screen new etomidate analogues without endocrine-disrupting effects is urgently warranted. Read More

J Hepatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

J Geriatr Oncol 2020 Jul 8. Epub 2020 Jul 8.

Medical Oncology Unit, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy.

Aim: This paper aims to analyze the usefulness of the G8 geriatric oncology questionnaire in patients with advanced/metastatic pancreatic adenocarcinoma (aPAC) and its possible association with different clinical outcomes.

Methods: Patients age > 70 years were screened with the G8 tool and treated with intravenous nab-paclitaxel 125 mg/m2 and gemcitabine 1000 mg/m2 for 3 consecutive weeks followed by one-week rest as prescribed after clinical evaluation by treating oncologists. Patient's charts were evaluated for type and severity of toxicity, 2 cycle rate of completion, discontinuation rate, delays, dose reductions, and other outcomes response rates, progression-free, and overall survival. Read More

J Environ Sci (China) 2020 Sep 7;95:240-247. Epub 2020 May 7.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; Shanghai Institute of Eco-Chongming (SIEC), Shanghai 200062, China. Electronic address:

Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are typical persistent organic pollutants (POPs), which have high toxicity, bioaccumulation and long-distance transfer capability. Daily variation, sources of PCBs and OCPs in PM are rarely explored in polluted rural area. Here, the sources and health risks of the PCBs and OCPs were evaluated for 48 PM samples collected in winter 2017 in Wangdu, a heavy polluted rural area in the North China Plain. Read More

Taiwan J Obstet Gynecol 2020 Jul;59(4):594-597

Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan. Electronic address:

Objective: Ultrasound-guided high-intensity focused ultrasound (USg-HIFU) has emerged in recent years as the new treatment modality for uterine myomas and adenomyosis with the advantages of being non-invasive, safe and effective. As its utility increases, adverse reactions emerge and deserve clinicians' attention for experience accrual. We herein report a case who suffered from acute renal insufficiency and thrombocytopenia immediately after receiving HIFU for uterine myomas. Read More

Lancet 2020 Jul 9. Epub 2020 Jul 9.

AP-HP, Sorbonne Université, Pitié-Salpêtrière Hospital, Department of Pharmacology and Clinical Investigation Centre, Paris 75013, France; INSERM, CIC-1901 and UMR-S 1166, Sorbonne Université, Faculty of Medicine, Paris, France.

Clin Epigenetics 2020 Jul 11;12(1):103. Epub 2020 Jul 11.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, 20892-7004, USA.

Background: Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be involved, but no prior epigenome-wide studies have investigated the impact of maternal POPs on placental DNA methylation. Read More

Cell Commun Signal 2020 Jul 11;18(1):111. Epub 2020 Jul 11.

Queens College and Graduate Center, City University of New York, 65-30 Kissena Blvd, NSB E143, Flushing, NY, 11367, USA.

Background: Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation. We evaluated the mechanism for this difference in the controlled situation of their response to ethanol.

Methods: We evaluated the expression of mRNA for alcohol dehydrogenase (ADH), aldehyde dehyrogenases (ALDH), and a cytochrome P450 isoenzyme (Cyp2e1) in male and female mice, comparing the expressions to toxicity under several experimental conditions evaluating redox and other states. Read More

Part Fibre Toxicol 2020 Jul 11;17(1):31. Epub 2020 Jul 11.

Laboratory for Particles-Biology Interactions, Empa, Swiss Federal Laboratories for Materials Science and Technology, Empa, Lerchenfeldstrasse 5, 9014, St.Gallen, Switzerland.

Background: Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life. Understanding the origin and mechanisms underlying NM-induced developmental toxicity will be a cornerstone in the protection of sensitive populations and the design of safe and sustainable nanotechnology applications.

Main Body: Direct toxicity originating from NMs crossing the placental barrier is frequently assumed to be the key pathway in developmental toxicity. Read More

Part Fibre Toxicol 2020 Jul 11;17(1):30. Epub 2020 Jul 11.

Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, 210009, P. R. China.

Background: Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues and tiny vascular structures. However, the biosafety of this novel QDs has not been thoroughly evaluated, especially in the central nervous system (CNS). The microarray analysis provides a hint that nitrogen-doped GQDs (N-GQDs) exposure could cause ferroptosis in microglia, which is a novel form of cell death dependent on iron overload and lipid peroxidation. Read More

Curr Drug Discov Technol 2020 Jul 12. Epub 2020 Jul 12.

Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran. Iran.

Aims: The aim of this study was to investigate the toxic effect of Echium amoenum plants on the liver and kidney of animal model.

Background: Echium amoenum is one of the medicinal plants containing pyrrolizidine alkaloids with several properties which has widely consumed among different communities.

Objective: The toxic effects of Echium amoenum on the liver and kidney were investigated in this study. Read More

J Tissue Eng Regen Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Collagen membranes and bone substitute are popular biomaterials in guided tissue regeneration for treatment of traumatized or diseased periodontal tissue. Development of these biomaterials starts in monolayer cell culture, failing to reflect in vivo tissue organization. Spheroid cultures potentially mimic in vivo tissues in structure and functionality. Read More

J Tissue Eng Regen Med 2020 Jul 11. Epub 2020 Jul 11.

Laboratory of Experimental Ophthalmology, Department of Ophthalmology, Pius-Hospital, Carl von Ossietzky University, Germany.

The shortage of donor corneas as well as the limitations of tissue substitutes leads to the necessity to develop alternative materials for ocular surface reconstruction. Corneal surface substitutes must fulfill specific requirements such as high transparency, low immunogenicity, and mechanical stability combined with elasticity. This in vitro study evaluates a decellularized matrix secreted from human corneal fibroblast (hCF) as an alternative material for ocular surface reconstruction. Read More

Pest Manag Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin, 150030, China.

Background: Herbicide safeners mitigate crop damage without reducing herbicide efficacy. Here, the protective effects of phenoxyacetyl oxazolidine derivatives as potential safeners were evaluated with a view toward reducing injury caused by sulfonylurea herbicide nicosulfuron to sensitive maize varieties.

Results: Growth indices demonstrated that the bioactivity of compound 9 (N-phenoxyacety-2-methyl-2,4-diethyl-1,3-oxazolidine) was superior to that of R-28725 and all other compounds tested. Read More

Pest Manag Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Entomology, Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha, 410125, China.

Background: The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, is one of the most devastating pests in citrus orchards, and has caused huge economic losses worldwide. Chemical control is the most effective way for psyllid control. Herein, the toxicity of nine insecticides to ACP adults and the joint action of thiamethoxam+spirotetramat were determined by a topical application method in the laboratory; field plot experiments were conducted to evaluate the control efficacy of one self-made thiamethoxam·spirotetramat 40% suspension concentrate (SC) comparing with thiamethoxam 21% SC, spirotetramat 22. Read More

Physiol Plant 2020 Jul 11. Epub 2020 Jul 11.

Department of Biomedical Science & Engineering, Konkuk University, Seoul, 05029, South Korea.

High salinity induces osmotic stress and often leads to sodium ion-specific toxicity, with inhibitory effects on physiological, biochemical, and developmental pathways. To cope with increased Na in soil water, plants restrict influx, compartmentalize ions into vacuoles, export excess Na from the cell, and distribute ions between the aerial and root organs. In this review, we discuss our current understanding of how High-Affinity K TRANSPORTERS (HKT) contribute to salinity tolerance, focusing on HKT1-like family members primarily involved in long-distance transport, and in the recent research in the model plant Arabidopsis and its halophytic counterparts of the Eutrema genus. Read More

Aging (Albany NY) 2020 Jul 11;12. Epub 2020 Jul 11.

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Polysaccharides (CPPs), a traditional Chinese medicine used for thousands of years, is a potential neuroprotective polysaccharide via a relatively poorly understood mechanism. We previously reported that CPPs attenuated tau pathology in hTau transfected mice and therefore in the current work investigated the effect of CPPs on Aβ toxicity and cognitive defects in APP/PS1 mice model. It was found that one-month intragastric administration of CPPs significantly ameliorated cognitive defects in APP/PS1 mice. Read More

Vet Parasitol 2020 Jun 29;283:109178. Epub 2020 Jun 29.

Department of Parasitology, University of Agriculture Faisalabad, Pakistan.

Ticks, particularly the Rhipicephalus which are the most prevalent and invasive affect 80 % of the cattle population worldwide. Through transmission of pathogens, tick worry and physical damage to the hides, ticks cause economic loss of billions of dollars each year with 1 billion US dollars loss per annum reported only in Latin-America. These losses can be minimized only by successful management of Rhipicephalus ticks. Read More

Bioresour Technol 2020 Jul 6;314:123785. Epub 2020 Jul 6.

Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address:

Global warming is a surging issue that has provoked the demand of green process to mitigate carbon dioxide. In this context, RuBisCo-equipped Escherichia coli has first developed and evaluated the CO-assimiliable capability based on the mass balance in three devices: Flask-based in CO incubator (FIC), two-layered device (TLD) and CO bubbling device (CBD) systematically. With the forced diffusion of 5% CO in CBD, which confers an efficient attack of CO to RuBisCo, the CO assimilation increased from -5. Read More

Eur J Med Chem 2020 May 31;201:112473. Epub 2020 May 31.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 315832, China. Electronic address:

Cyanobacteria are one of the oldest creatures on earth, originated 3.5-3.3 billion years ago, and are distributed all over the world, including freshwater ponds and lakes, hot springs, and polar ice, especially in tropical and subtropical marine locations. Read More

Eur J Med Chem 2020 Jun 16;201:112480. Epub 2020 Jun 16.

Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

As part of our effort to develop potential tyrosinase inhibitors, we have conjugated the well-known tyrosinase inhibitor kojic acid (KA) with several phenolic natural products such as umbelliferone, sesamol, thymol, carvacrol, eugenol, isoeugenol, vanillin, isovanillin, and apocynin that some reports have shown their activity on tyrosinase enzyme. The designed compounds were synthesized using click reaction and 1,2,3-triazole formation. All compound showed potent anti-tyrosinase activity significantly higher than KA. Read More

J Hazard Mater 2020 Jul 2;401:123376. Epub 2020 Jul 2.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address:

Imidazolium based ionic liquids (ILs) have been extensively used in the various industrial fields, however, the dependence of their structure on toxicity and bioavailability by plants is not clear. Thus, in this study, uptake of imidazolium based ILs with different alkyl chain lengths (e.g. Read More

J Hazard Mater 2020 Jul 2;401:123365. Epub 2020 Jul 2.

Plant Physiology and Biochemistry Laboratory, Department of Botany, Aligarh Muslim University, Aligarh, 202002, India. Electronic address:

We studied the role of HO in the protection of photosynthesis from arsenic (As) damage in rice (Oryza sativa L.) by examining the antioxidant system, photosynthesis, and growth attributes. Among the As concentrations (0, 20, 30, 40 and 50 μM) tested, maximum oxidative stress and inhibition in photosynthesis and growth were found with 50 μM As. Read More

J Hazard Mater 2020 Jul 1;401:123356. Epub 2020 Jul 1.

School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address:

This study reported the kinetics and mechanism of degradation of odorant haloanisoles by peracetic acid combined with UV irradiation (PAA/UV). The removal efficiency of haloanisoles by PAA/UV was more than 92 % after 1 h reaction at pH 5, 25 °C, [HAs] =50 μg/L and [PAA] = 10 mg/L. The degradation of haloanisoles was fitted by the first-order kinetic model, and the rate constants of various haloanisoles followed the order: 2,4,6-tribromoanisole (2,4,6-TBA, (9. Read More

Eur J Med Chem 2020 Jun 30;202:112475. Epub 2020 Jun 30.

Department of Pharmacy, Affiated Tumor Hospital of Guangxi Medical University, Nanning, PR China. Electronic address:

A series of rasagiline-clorgyline hybrids was designed, synthesized and investigated in vitro for their inhibition of monoamine oxidase and amyloid-β aggregation. Most of compounds were found to be selective and highly potent hMAO-B inhibitors showing IC values in the nanomolar, and exhibited a moderate inhibition of amyloid-β aggregation. 7-((5-(methyl(prop-2-yn-1-yl)amino) pentyl)oxy)chroman-4-one (6j) was the most interesting compound identified in this research, endowed with higher hMAO-B potency (IC = 4 nM) and selectivity (SI > 25000) compared to the reference selective inhibitor rasagiline (IC = 141 nM, SI > 355), and exhibited good inhibitory activity against Aβ aggregation (40. Read More

Epilepsy Behav 2020 Jul 8;111:107284. Epub 2020 Jul 8.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States of America. Electronic address:

Purpose: Lamotrigine (LTG) is one of the most used antiseizure medications (ASMs). Titration is indicated for incomplete seizure control, but toxicity with vertigo, ataxia, and diplopia may ensue. Lamotrigine concentration would be the optimal diagnostic test. Read More

J Inorg Biochem 2020 Jul 2;210:111168. Epub 2020 Jul 2.

Institute of Biology, Komi Science Centre, Ural Branch of Russian Academy of Sciences, 167982, 28 Kommunisticheskaya St., Syktyvkar, Russia.

The ever increasing demand for nanoantioxidants with minimized toxicity dictates the necessity to develop new biocompatible materials. One promising approach is the immobilization of polyphenols on metal (oxy)hydroxide nanoparticles (NPs) that possess the desired chemical and colloidal stability while also allowing to dispose of the antioxidants more safely and effectively. In this paper we modify sol-gel synthesized γ-AlOOH NPs with curcumin molecules. Read More

Am J Infect Control 2020 Jul 8. Epub 2020 Jul 8.

Scientific Direction, Clínica de Marly Jorge Cavelier Gaviria. Avenida Paseo los Zipas, Cl. 29, Chía, Colombia. Electronic address:

Introduction: As has happened in other emerging respiratory pandemics, demand for N95 filtering facemask respirators (FFRs) has far exceeded their manufacturing production and availability in the context of the SARS-CoV-2 pandemic. One of the proposed strategies for mitigating the massive demand for N95 FFRs is their reuse after a process of decontamination that allows the inactivation of any potentially infectious material on their surfaces. This article aims to summarize all of the available evidence on the different decontamination methods that might allow disposable N95 FFRs to be reused, with emphasis on decontamination from SARS-CoV-2. Read More

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

The First Affiliated Hospital; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; School of Medicine, Zhejiang University, Hangzhou, 310003, PR China. Electronic address:

Although some formats of nanomedicines are now available for clinical use, the translation of new nanoparticles to the clinic remains a considerable challenge. Here, we describe a simple yet cost-effective strategy that converts a toxic drug, cabazitaxel, into a safe and effective nanomedicine. The strategy involves the ligation of drug molecules via a self-immolating spacer, followed by dimerization-induced self-assembly to assemble stable nanoparticles. Read More