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J Appl Microbiol 2022 May 22. Epub 2022 May 22.

Amity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida, Uttar Pradesh, India.

The use of surfactants in households and industries is inevitable and so is their discharge into the environment, especially into the water bodies as effluents. Being surface-active agents, their utilization is mostly seen in soaps, detergents, personal care products, emulsifiers, wetting agents, etc. Anionic surfactants are the most used class. Read More

Stem Cell Res Ther 2022 May 21;13(1):210. Epub 2022 May 21.

Department of Tumor Biology, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Poland.

Etiopathogenesis of fluoroquinolone-associated disability (FQAD) syndrome is not fully understood, yet research could progress by utilizing induced pluripotent stem cells (iPSc) from people with this syndrome. Similarly, iPSc, or rather their derivatives, could be used in their therapy, not only for FQAD but also for other disorders in which generated autologous iPSc and their derivatives might be helpful. Urine was collected from ten donors with FQAD, and reprogramming of these cells was conducted with the use of Epi5TM Episomal iPSC Reprogramming Kit. Read More

Sci Rep 2022 May 21;12(1):8623. Epub 2022 May 21.

Center for Life Nano- and Neuro-Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy.

Blind-structured illumination microscopy (blind-SIM) enhances the optical resolution without the requirement of nonlinear effects or pre-defined illumination patterns. It is thus advantageous in experimental conditions where toxicity or biological fluctuations are an issue. In this work, we introduce a custom convolutional neural network architecture for blind-SIM: BS-CNN. Read More

Clin Oncol (R Coll Radiol) 2022 May 18. Epub 2022 May 18.

The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK.

Aims: Inclusion of the internal mammary chain in the radiotherapy target volume (IMC-RT) improves disease-free and overall survival in higher risk breast cancer patients, but increases radiation doses to heart and lungs. Dosimetric data show that either modified wide-tangential fields (WT) or volumetric modulated arc therapy (VMAT) together with [AQ1]voluntary deep inspiration breath hold (vDIBH) keep mean heart doses below 4 Gy in most patients. However, the impact on departmental resources has not yet been documented. Read More

Gynecol Oncol 2022 May 18. Epub 2022 May 18.

New York University School of Medicine, New York, NY, USA.

Toxicon 2022 May 18. Epub 2022 May 18.

Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt. Electronic address:

Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin that induces severe health disturbances in humans and animals. This study aimed to determine the bioactive compounds in Costus speciosus extract (CSE) using GC-MS and evaluate its protective capability against ZEN-induced oxidative damage, genotoxicity, and cytotoxicity in rats. Six groups of male Sprague Dawley rats were treated orally for 15 days including the control group, CSE-treated groups at low (200 mg/kg b. Read More

Toxicol Lett 2022 May 18. Epub 2022 May 18.

Tianjin State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

The interaction between small-molecule compounds of traditional Chinese medicine and their direct targets is the molecular initiation event, which is the key factor for toxicity efficacy. Psoralen, an active component of Fructus Psoraleae, is toxic to the liver and has various pharmacological properties. Although the mechanism of psoralen-induced hepatotoxicity has been studied, the direct target of psoralen remains unclear. Read More

Environ Pollut 2022 May 18:119488. Epub 2022 May 18.

Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Key Laboratory of Regulating and Controlling Crop Growth and Development Ministry of Education, Henan Agricultural University, Zhengzhou, Henan, 450046, China.

Nitric oxide (NO) is an important phytohormone for plant adaptation to mercury (Hg) stress. The effect of Hg on lignin synthesis, NO production in leaf, sheath and root and their relationship were investigated in two members of the grass family - wheat and maize. Hg stress decreased growth and lignin contents, significantly affected phenylpropanoid and monolignol pathways (PAL, phenylalanine ammonia-lyase; 4-coumarate: CoA ligase, 4CL; cinnamyl alcohol dehydrogenase, CAD), with maize identified to be more sensitive to Hg stress than wheat. Read More

Environ Pollut 2022 May 18:119492. Epub 2022 May 18.

University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water- and Waste-Management, Laboratory of Soil- and Groundwater-Management, Pauluskirchstraße 7, 42285, Wuppertal, Germany. Electronic address:

Trace elements (TEs) contamination of agricultural soils requires suitable criteria for regulating their toxicity limits in soil and food crops, which depends on their potential ecological risk spanning regional to global scales. However, no comprehensive study is available that links TE concentrations in paddy soil with ecological and human health risks in less developed regions like Pakistan. Here we evaluated the data set to establish standard guidelines for defining the hazard levels of various potentially toxic TEs (such as As, Cd, Co, Cu, Cr, Fe, Mn, Ni, Pb, Se, Zn) in agricultural paddy soils of Punjab, Pakistan. Read More

Cancer Lett 2022 May 18:215719. Epub 2022 May 18.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China. Electronic address:

Unlike non-small-cell lung cancer (NSCLC), the progression of small-cell lung cancer (SCLC) is slow. Extensive-stage SCLC (ES-SCLC) is a serious threat to human health, with a 5-year survival rate of <7%. Chemotherapy has been the first-line treatment for the past 30 years. Read More

Chemosphere 2022 May 18:135009. Epub 2022 May 18.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address:

Benzene poisoning is a common adverse blood outcome in occupational workers, manifested by hematopoietic dysfunction. However, the specific phenotype and its mechanisms of early hematopoietic toxicity caused by benzene remain unclear. After 15 days of exposure, the WBC levels were not significantly altered in benzene-exposed mice. Read More

Chemosphere 2022 May 18:135002. Epub 2022 May 18.

Graduate Program in Engineering, University of Passo Fundo, Brazil.

The use of nano zero-valent iron (nZVI) for the remediation of degraded areas is a consolidated practice. However, the long-term reactions that occur in the environment remain unknown. This study aimed to evaluate the potential toxic effects on the growth of colony-forming units (CFUs) of Bacillus cereus and Pseudomona aeruginosa present in soil contaminated with hexavalent chromium (Cr) and pentachlorophenol (PCP) nanoremediated with nZVI. Read More

Fish Shellfish Immunol 2022 May 18. Epub 2022 May 18.

College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning, 530007, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangzhou, 510006, China. Electronic address:

Nanoplastics (NPs) are good carriers of persistent organic pollutants (POPs) such as polybrominated diphenyl ethers (PBDEs), and can alter their bioavailability and toxic impacts to aquatic organisms. This study highlights the single and combined toxic effects of polystyrene nanoplastics (PS-NPs) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47, one of the dominant congeners of PBDEs) on zebrafish embryos after an exposure duration of up to 120 hpf. Results showed that PS-NPs and BDE-47 co-exposure exacerbated the morphological deformities in terms of pericardial edema, yolk sac edema and curved tail in zebrafish larvae. Read More

Pharmacol Ther 2022 May 18:108213. Epub 2022 May 18.

Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA.

Adenosine is a ubiquitous endogenous nucleoside or autacoid that affects the cardiovascular system through the activation of four G-protein coupled receptors: adenosine A receptor (AAR), adenosine A receptor (AAR), adenosine A receptor (AAR), and adenosine A receptor (AAR). With the rapid generation of this nucleoside from cellular metabolism and the widespread distribution of its four G-protein coupled receptors in almost all organs and tissues of the body, this autacoid induces multiple physiological as well as pathological effects, not only regulating the cardiovascular system but also the central nervous system, peripheral vascular system, and immune system. Mounting evidence shows the role of CYP450-enzymes in cardiovascular physiology and pathology, and the genetic polymorphisms in CYP450s can increase susceptibility to cardiovascular diseases (CVDs). Read More

Sci Total Environ 2022 May 18:156012. Epub 2022 May 18.

University of Natural Resources and Life Sciences Vienna (BOKU), Department of Integrative Biology and Biodiversity Research, Institute of Zoology, Gregor Mendel Straße 33, 1180 Vienna, Austria.

Little is known about (i) how numbers and concentrations of airborne pesticide residues are influenced by land use, interactions with meteorological parameters, or by substance-specific chemo-physical properties, and (ii) what potential toxicological hazards this could pose to non-target organisms including humans. We installed passive air samplers (polyurethane PUF and polyester PEF filter matrices) in 15 regions with different land uses in eastern Austria for up to 8 months. Samples were analyzed for 566 substances by gas-chromatography/mass-spectrometry. Read More

Sci Total Environ 2022 May 18:155825. Epub 2022 May 18.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Microplastics (MPs), as a new environmental pollutant, have received widespread attention worldwide. Uterine fibrosis is one of the main factors of female reproductive disorders. However, it is unclear whether the female reproductive disorders caused by MPs are related to uterine fibrosis. Read More

Sci Total Environ 2022 May 18:155811. Epub 2022 May 18.

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China. Electronic address:

Plastic particles, especially nanoplastics, represent an emerging concern of threat to human health, oral uptake is an important pathway for the plastic particles ingestion by human. While their fate and adverse effects in animal gastrointestinal tract are increasingly investigated, knowledge about their uptake and toxicity in human intestine is still limited. Here, by exposing human intestinal organoids to polystyrene nanoplastics (PS-NPs, ~50 nm in size) with concentrations of 10 and 100 μg/mL, we present evidence of their distinct accumulation in various type cells in intestinal organoids, then causing the cell apoptosis and inflammatory response. Read More

Sci Total Environ 2022 May 18:156000. Epub 2022 May 18.

Unit of Plant Protection Products, National Institute for Agricultural and Food Research and Technology INIA-CSIC, Ctra. La Coruña, Km. 7.5, 28040 Madrid, Spain.

Any active substance with phytosanitary capacity intended to be marketed in Europe must pass exhaustive controls to assess its risk before being marketed and used in European agriculture. Since the implementation of Regulation (EC) No 1107/2009, agrochemical companies have been obliged to study the formation of pesticide transformation products (TPs) during the treatment of drinking water containing pesticide residues. However, there is no consensus on how to address this requirement. Read More

Adv Drug Deliv Rev 2022 May 18:114336. Epub 2022 May 18.

IBM Thomas J. Watson Research, Yorktown Heights, New York, 10598, USA. Electronic address:

Two-dimensional (2D) nanomaterials such as graphene are increasingly used in research and industry for various biomedical applications. Extensive experimental and theoretical studies have revealed that 2D nanomaterials are promising drug delivery vehicles, yet certain materials exhibit toxicity under biological conditions. So far, it is known that 2D nanomaterials possess strong adsorption propensities for biomolecules. Read More

Environ Res 2022 May 18:113492. Epub 2022 May 18.

Department of Endocrinology, Odense University Hospital, Søndre Blvd. 29, 5000, Odense C, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000, Odense, Denmark.

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). Read More

Bioorg Chem 2022 May 15;124:105872. Epub 2022 May 15.

Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Tenerife, Islas Canarias, Spain; Departamento de Obstetricia y Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología, Medicina Legal y Forense y Parasitología, Universidad de La Laguna, Tenerife, Islas Canarias, Spain; Red de Investigación Colaborativa en Enfermedades Tropicales (RICET), Instituto de Salud Carlos III, Spain; Consorcio Centro de Investigación Biomédica En Red M.P. (CIBER) de Enfermedades Infecciosas, Inst. de Salud Carlos III, 28006 Madrid, Spain. Electronic address:

Leishmaniasis produces approximately-one million of new cases annually, making it one of the most important tropical diseases. As current treatments are not fully effective and are toxic, it is necessary to develop new therapies that are more effective and less toxic, and cause a controlled cell death, with which we can avoid the immunological problems caused by necrosis. In this work 32 acrylonitriles were studied in vitro against Leishmania amazonensis. Read More

Breast 2022 May 16;64:56-62. Epub 2022 May 16.

Centre for Health Equity, The University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address:

Background: Detailed toxicity data are routinely collected in breast cancer (BC) clinical trials. However, ovarian toxicity is infrequently assessed, despite the adverse impacts on fertility and long-term health from treatment-induced ovarian insufficiency.

Objectives: To determine the barriers to and facilitators of ovarian toxicity assessment in BC trials of anti-cancer drugs. Read More

Int Immunopharmacol 2022 May 19;108:108848. Epub 2022 May 19.

School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan; Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan; Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung, Taiwan. Electronic address:

Backgrounds: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy (CT) are the standard of care for first-line therapy in metastatic non-small cell lung cancer (NSCLC) patients without actionable mutations. The safety ranking of different ICI and CT combination regimens has not been investigated. This study was aimed to provide a toxicity profile and safety ranking of different ICI and CT combination regimens. Read More

J Plant Physiol 2022 May 13;274:153720. Epub 2022 May 13.

Institute for Multidisciplinary Research in Applied Biology (IMAB), Public University of Navarre, Campus Arrosadia s/n, 31006, Pamplona, Spain. Electronic address:

The present study aimed to determine whether glyphosate-induced oxidative stress is directly related to the action mechanism of this herbicide (5-enolpyruvylshikimate-3-phosphate synthase or EPSPS inhibition) and analyse the role of oxidative stress in glyphosate toxicity of the weed Amaranthus palmeri S. Wats. Two kinds of populations were studied using EPSPS amplification: glyphosate-sensitive and glyphosate-resistant (by gene amplification). Read More

Food Chem 2022 May 13;390:133183. Epub 2022 May 13.

Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China; Key Laboratory of Tea Quality and Safety & Risk Assessment, Ministry of Agriculture, Hangzhou 310008, China. Electronic address:

Pyrrolizidine alkaloids (PAs) and pyrrolizidine alkaloid N-oxides (PANOs) are toxic secondary metabolites in plants, and one kind of main exogenous pollutants of tea. Herein, the dissipation pattern and conversion behavior of PAs/PANOs were investigated during tea manufacturing and brewing using ultra high-performance liquid chromatography tandem mass spectrometry. Compared with PAs (processing factor (PF) = 0. Read More

J Colloid Interface Sci 2022 May 10;623:417-431. Epub 2022 May 10.

National Engineering Research Center for Marine Aquaculture, Institute of Innovation & Application, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China. Electronic address:

High-performance and stabilized photocatalytic degradation of antibiotic contaminants still remains a challenge in environmental photocatalysis and has been studied worldwide. In this work, hybrid Au and C60 quantum dots decorated Materials of Institute Lavoisier-125(Ti) (MIL-125(Ti)) composites were successfully fabricated for visible-light photocatalytic tetracycline degradation with pristine MIL-125(Ti) as a comparison. The experimental results revealed that the introduction of C60 quantum dots and Au nanoparticles resulted in highly enhanced visible-light harvesting and charge separation for efficient tetracycline degradation. Read More

Eur J Med Chem 2022 May 13;238:114454. Epub 2022 May 13.

Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

Tuberculosis, a disease of poverty is a communicable infection with a reasonably high mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million deaths in the year 2019. Read More

Mar Pollut Bull 2022 May 18;180:113757. Epub 2022 May 18.

Key Laboratory of Humid Subtropical Eco-geographical Process (Fujian Normal University), Ministry of Education, Fuzhou 350007, PR China; Fujian Provincial Key Laboratory for Subtropical Resources and Environment, Fujian Normal University, Fuzhou 350007, PR China.

To explore the pollution levels, sources and risks of heavy metals in sediments in Fuzhou reach of the Min River, the sediments involving in seven marsh types were sampled. Results showed that the concentrations of Pb, Zn and Cd in sediments declined from freshwater segment to estuarine segment. Higher levels of Cu, Cr and Ni in sediments generally occurred in estuarine segment. Read More

Mar Pollut Bull 2022 May 18;180:113723. Epub 2022 May 18.

Aix-Marseille University, CNRS, IRD, INRA, Coll France, CEREGE, Aix-en-Provence, France.

Metal pollution in rivers should not be overlooked before their entry into the sea. However, there are few studies for estimating such contamination in rivers entering the Algerian coastal waters. Semimonthly quantification of dissolved and particulate metals, near the mouths of two industrial-tainted rivers, El Harrach and Mazafran rivers, was carried out during a period of one year. Read More

Qual Life Res 2022 May 21. Epub 2022 May 21.

Faculty of Science, School of Psychology, Sydney Quality of Life Office, The University of Sydney, Sydney, Australia.

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity of cancer treatment, with potential to significantly impact cancer survivors' long-term quality of life. Patient reported outcome measures (PROMs) are increasingly utilised to evaluate CIPN. However, guidance remains lacking on how to identify fit for purpose PROMs with considerations necessarily differing when used in various research and in-clinic contexts. Read More