Bioorg Chem 2022 May 15;124:105872. Epub 2022 May 15.
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Tenerife, Islas Canarias, Spain; Departamento de Obstetricia y Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología, Medicina Legal y Forense y Parasitología, Universidad de La Laguna, Tenerife, Islas Canarias, Spain; Red de Investigación Colaborativa en Enfermedades Tropicales (RICET), Instituto de Salud Carlos III, Spain; Consorcio Centro de Investigación Biomédica En Red M.P. (CIBER) de Enfermedades Infecciosas, Inst. de Salud Carlos III, 28006 Madrid, Spain. Electronic address:
Leishmaniasis produces approximately-one million of new cases annually, making it one of the most important tropical diseases. As current treatments are not fully effective and are toxic, it is necessary to develop new therapies that are more effective and less toxic, and cause a controlled cell death, with which we can avoid the immunological problems caused by necrosis. In this work 32 acrylonitriles were studied in vitro against Leishmania amazonensis. Read More