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Polymers (Basel) 2018 May 3;10(5). Epub 2018 May 3.

Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.

Hyperlipidemia is a key risk factor in inducing fatty liver, hypertension, atherosclerosis and cerebrovascular diseases. Previous studies have verified that polysaccharides from fruiting bodies (PEPE) of (king oyster mushroom) are capable of decreasing the lipid content. In this study, the polysaccharide is obtained by solid-state fermentation (PESF) using lignocellulosic wastes, corn-cobs and wheat bran. Read More

Molecules 2019 Mar 28;24(7). Epub 2019 Mar 28.

Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.

(AC) is a rare and unique mushroom that is difficult to cultivate. Previous studies have demonstrated the bioactivity of the compound Ergosta-7,9(11),22-trien-3β-ol (EK100) from AC in submerged culture. The purpose of this study is to evaluate the potential beneficial effects of EK100 on fatigue and ergogenic functions following physiological challenge. Read More

Food Chem Toxicol 2019 May 25;127:228-236. Epub 2019 Mar 25.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Mushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Read More

Sci Rep 2019 Mar 25;9(1):5073. Epub 2019 Mar 25.

Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000, Ljubljana, Slovenia.

Aegerolysins ostreolysin A (OlyA) and pleurotolysin A (PlyA), and pleurotolysin B (PlyB) with the membrane-attack-complex/perforin domain are proteins from the mushroom genus Pleurotus. Upon binding to sphingomyelin/cholesterol-enriched membranes, OlyA and PlyA can recruit PlyB to form multimeric bi-component transmembrane pores. Recently, Pleurotus aegerolysins OlyA, PlyA2 and erylysin A (EryA) were demonstrated to preferentially bind to artificial lipid membranes containing 50 mol% ceramide phosphoethanolamine (CPE), the main sphingolipid in invertebrate cell membranes. Read More

BMC Genomics 2019 Mar 25;20(1):243. Epub 2019 Mar 25.

Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog-Weg 4, CH-8093, Zürich, Switzerland.

Background: Fungi are an attractive source of nutrients for predators. As part of their defense, some fungi are able to induce the production of anti-predator protein toxins in response to predation. A previous study on the interaction of the model mushroom Coprinopsis cinerea by the fungivorous nematode Aphelenchus avenae on agar plates has shown that the this fungal defense response is most pronounced in the part of the mycelium that is in direct contact with the nematode. Read More

Med Chem 2019 03 18. Epub 2019 Mar 18.

Plasma Bioscience Research Center, Kwangwoon University, 20 Kwangwoon-gil, Nowon-gu, Seoul 139-701. Korea.

Background: Tyrosinase is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments leading to hyperpigmentation disorders. Controlling the melanogenesis could be an important strategy for treating abnormal pigmentation.

Methods: In present study a series of amide derivatives (3a-e and 5a-e) were synthesized aiming to inhibit tyrosinase activity and melanin production. Read More

Arch Toxicol 2019 Mar 19. Epub 2019 Mar 19.

Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, UCIBIO, REQUIMTE, University of Porto, Rua José Viterbo Ferreira no 228, 4050-313, Porto, Portugal.

Amanita phalloides is one of the most toxic mushrooms worldwide, and it is involved in the majority of human fatal cases of mushroom poisoning. α-Amanitin, the most deleterious toxin of A. phalloides to humans, inhibits RNA polymerase II (RNAPII), causing hepatic and renal failure. Read More

Int J Mol Sci 2019 Mar 6;20(5). Epub 2019 Mar 6.

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea.

, an edible mushroom, is known to have anti-cancer, anti-inflammatory, and anti-diabetes effects. However, the underlying anti-cancer mechanism of is unknown. To determine the molecular mechanism of the anti-cancer effects of , various methods were used including fluorescence-activated cell sorting, Western blotting, migration, and crystal violet assays. Read More

Int J Med Mushrooms 2018 ;20(12):1197-1207

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India; International Scientific Partnership, College of Science, King Saud University, Riyadh, Saudi Arabia.

This study was conducted to determine the mosquitocidal activity of 6 species of higher Basidiomycetes collected from various places in the state of Tamil Nadu, India. The mushrooms were identified using MycoKey MMI software. We used morphological characteristics such as size, color, height, width (of the cap, lamellae, stipe, and fruiting body), spore deposits, and the presence or absence of ring to identify species. Read More

Int J Med Mushrooms 2018 ;20(12):1185-1195

Centre of Studies for Industrial Biotechnology, Universidad de Oriente, Santiago de Cuba, Cuba.

A compositional study was performed on fruiting-body powder of the culinary-medicinal oyster mushroom Pleurotus ostreatus for applications as a nutraceutical/functional food. Carbohydrates (55 g/100 g dry weight [dw]) and proteins (27.45 g/100 g dw, with an in vitro digestibility of 75%) appear to be the major components, but fat content was low (4 g/100 g dw). Read More

Int J Med Mushrooms 2019 ;21(1):29-35

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW 2007, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305, Australia.

Auricularia polytricha is a popular mushroom found all over the world. This article describes a study of the antiepileptic effect of A. polytricha, a mushroom that is used traditionally for treating asthma, rheumatism, tumors, cough, fever, and epilepsy, and for its antimicrobial effect. Read More

Int J Med Mushrooms 2019 ;21(2):193-203

Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria.

Termitomyces robustus is an edible and highly nutritious wild Basidiomycetes mushroom. It is used in ethnomedicine for treating malnutrition-related diseases, rheumatism, diarrhea, gonorrhea, anemia, and hypertension. Despite the tremendous use of this delicious edible mushroom as a source of nutrients, no comprehensive literature describes its safety and toxicity profiles. Read More

Int J Med Mushrooms 2019 ;21(2):143-154

Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.

Ganoderma lucidum is a hard, bitter mushroom with many ethnomedicinal uses, including conditions similar to lead (Pb) toxicity. The aim of this study was to evaluate the protective effects of a G. lucidum aqueous extract (GL) when concurrently administered with Pb. Read More

J Agric Food Chem 2019 Mar 26;67(10):2865-2876. Epub 2019 Feb 26.

The First Affiliated Hospital, and Department of Chemistry , Jinan University , Guangzhou 510632 , China.

Selenium nanoparticles (SeNPs) are recently emerging as promising anticancer agents because of their high bioavailability, low toxicity and remarkable anticancer activities. However, the effects of surface physicochemical properties on the biological actions remain elusive. Herein we decorated SeNPs with various water-soluble polysaccharides extracted from various mushrooms, to compare physical characteristics and anticancer profile of these SeNPs. Read More

Mycologia 2019 Jan-Feb;111(1):161-176. Epub 2019 Feb 4.

c Fungus/Mushroom Resource and Research Center, Faculty of Agriculture , Tottori University , 4-101 Koyama-Minami, Tottori 680-8553 , Japan.

Homolka's perlite protocol (HPP) was evaluated for cryopreservation of a wide range of ectomycorrhizal basidiomycete cultures, then a modified perlite protocol (MPP), in which cryoprotectant was added just before freezing rather than during the culturing process, was applied to cryosensitive strains that failed to survive when HPP was used. Further modifications of MPP with various cryoprotectants were explored to improve the cryopreservation of hard-to-preserve strains. The efficacy of HPP was assessed in 111 strains of 38 species of basidiomycetes of various cryosensitivities. Read More

Toxicol Rep 2019 9;6:143-150. Epub 2019 Jan 9.

Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mushrooms account for a part of human diet due to their exquisite taste and protein content as well as their promising health effects unveiled by scientific research. Toxic and non-toxic mushrooms frequently share considerable morphological similarities, which mislead the collectors/consumers, resulting in mycotoxicity. Numerous mushroom species are considered "poisonous" as they produce dangerous toxins. Read More

Chin J Nat Med 2019 Jan;17(1):33-42

Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China. Electronic address:

Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Read More

Mol Pharmacol 2019 Apr 29;95(4):337-348. Epub 2019 Jan 29.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation (E.P., D.C., I.B.); Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas (H.Z., I.B.); Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russian Federation (T.Y.P., A.V.Z.); VVS Laboratory Inc., Ulica Dostoevskogo 44, St. Petersburg, Russian Federation (K.P., E.F.); Institute of Biomedical Chemistry, Moscow, Russian Federation (V.P.)

Alzheimer's disease (AD) is a neurodegenerative disorder that is the major cause of dementia in the elderly. There is no cure against AD. We have recently discovered a novel transient receptor potential canonical 6 (TRPC6)-mediated intracellular signaling pathway that regulates the stability of dendritic spines and plays a role in memory formation. Read More

Food Chem Toxicol 2019 Mar 23;125:383-391. Epub 2019 Jan 23.

Fine Chemical and Natural Products Laboratory, School of Chemistry, IRNASUS-CONICET, Catholic University of Córdoba, Avda. Armada Argentina 3555, X5016DHK, Córdoba, Argentina. Electronic address:

To contribute enzymatic browning inhibitors to the food industry and also extend knowledge about the phytochemical profile of the anti-tyrosinase plant Lepechinia meyenii, its ethanol extract was subjected to bioguided fractionation. Three hydroxycinnamic acids, p-coumaric acid (1), caffeic acid (2) and rosmarinic acid (3), were isolated as mainly responsible for its activity. Compounds 1, 2 and 3 showed themselves highly effective for inhibiting tyrosinase with IC values of 0. Read More

Food Chem 2019 May 3;281:269-284. Epub 2019 Jan 3.

West China School of Public Health, Sichuan University, Chengdu 610041, China; Provincial Key Laboratory for Food Safety Monitoring and Risk Assessment of Sichuan, Chengdu 610041, China. Electronic address:

Owing to the strong concentration and biotransformation of arsenic, the influence of some edible mushrooms on human health has attracted widespread attention. The toxicity of arsenic greatly depends on its species, so the speciation analysis of arsenic is of critical importance. The aim of the present review is to highlight recent advances in arsenic speciation analysis in edible mushrooms. Read More

Int J Phytoremediation 2018 17;20(14):1389-1399. Epub 2019 Jan 17.

d Guizhou Institute of Prataculture , Guiyang , Guizhou , China.

Phytoremediation is a kind of efficient strategy for remediating soils polluted with heavy metals. The aim of this study was to investigate the influence of spent mushroom substrate (SMS) on the phytoremediation potential of Ricinus communis in Cd- and Zn-polluted soil. We treated the soil with SMS before growing plants and analyzed the contents, distribution of heavy metals, and response of plants after growth. Read More

Molecules 2019 Jan 15;24(2). Epub 2019 Jan 15.

Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.

Twelve compounds (⁻) were isolated from the methanol extract of brick cap mushroom ( (Schaeff.) P. Kumm. Read More

Front Pharmacol 2018 17;9:1449. Epub 2018 Dec 17.

Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause of cancer-related death worldwide. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in HCC and has been proposed as a chemotherapeutic target for HCC. (AC), a medicinal mushroom unique to Taiwan, is traditionally used for treating HCC. Read More

Res Pharm Sci 2018 Dec;13(6):533-545

Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.

() subsp. has been used in traditional medicine and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n-hexane, dichloromethane (CHCl), n-butanol (BuOH), ethyl acetate (EtOAc), water extracts and essential oil of subsp. Read More

J Med Food 2019 Feb 31;22(2):225-227. Epub 2018 Dec 31.

1 Faculty of Agriculture, Kyushu University , Fukuoka, Japan .

In the present study, ethanol extracts of 90 wild mushroom samples from Nepal, and the pure compound hispidin, were screened for their ability to inhibit β-hexosaminidase release (BHR) from rat basophilic leukemia-2H3 cells. Simultaneously, the toxicity of the extracts toward the cells was also determined, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Samples belonging to the groups Hymenochaetales and Polyporales showed promising anti-allergic activity, with Phellinus adamantinus and Ganoderma lingzhi 3 allowing a mere 19. Read More

Neurobiol Dis 2019 Apr 27;124:489-504. Epub 2018 Dec 27.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia. Electronic address:

There is evidence that cognitive decline in Alzheimer's disease (AD) results from deficiencies in synaptic communication (e.g., loss of mushroom-shaped 'memory spines') and neurodegenerative processes. Read More

Elife 2018 12 21;7. Epub 2018 Dec 21.

Division of Neuroscience, Biomedical Sciences Research Centre "Alexander Fleming", Vari, Greece.

Habituation is the process that enables salience filtering, precipitating perceptual changes that alter the value of environmental stimuli. To discern the neuronal circuits underlying habituation to brief inconsequential stimuli, we developed a novel olfactory habituation paradigm, identifying two distinct phases of the response that engage distinct neuronal circuits. Responsiveness to the continuous odor stimulus is maintained initially, a phase we term habituation latency and requires Rutabaga Adenylyl-Cyclase-depended neurotransmission from GABAergic Antennal Lobe Interneurons and activation of excitatory Projection Neurons (PNs) and the Mushroom Bodies. Read More

Int J Environ Res Public Health 2018 12 14;15(12). Epub 2018 Dec 14.

Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

The consequences of mushroom poisoning range from mild, mostly gastrointestinal, disturbances to organ failure or even death. This retrospective study describes presentations related to mushroom poisoning at an emergency department in Bern (Switzerland) from January 2001 to October 2017. Gastrointestinal disturbances were reported in 86% of the 51 cases. Read More

Ecotoxicol Environ Saf 2019 Mar 23;169:523-528. Epub 2018 Nov 23.

Universidade Estadual Paulista (UNESP), Centro de Estudos de Insetos Sociais (CEIS), Instituto de Biociências, Campus Rio Claro, SP, Brazil.

Thiamethoxam (TMX) is a neurotoxic insecticide widely used for insect pest control. TMX and other neonicotinoids are reported to be potential causes of honey bee decline. Due to its systematic action, TMX may be recovered in pollen, bee bread, nectar, and honey, which make bees likely to be exposed to contaminated diet. Read More

J Cell Mol Med 2019 Jan 15;23(1):4-20. Epub 2018 Nov 15.

Medical Systems Biology Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China.

Poria cocos is an edible medicinal fungus known as "Fuling" in Chinese and has been used as a Chinese traditional medicine for more than two thousand years. Pharmacological studies reveal that polysaccharide is the most abundant substance in Poria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti-inflammation, antioxidation, anti-ageing, antihepatitis, antidiabetics and anti-haemorrhagic fever effects. As a result, "Poria cocos polysaccharide oral solution" was developed and sold as an over-the-counter health supplement since 1970s. Read More

Toxicon 2019 Jan 12;157:53-65. Epub 2018 Nov 12.

Dept. for Clinical Toxicology at II, Med. Klinik, TU, München, Munich, Germany.

Mushroom poisoning is a significant and increasing form of toxin-induced-disease. Existing classifications of mushroom poisoning do not include more recently described new syndromes of mushroom poisoning and this can impede the diagnostic process. We reviewed the literature on mushroom poisoning, concentrating on the period since the current major classification published in 1994, to identify all new syndromes of poisoning and organise them into a new integrated classification, supported by a new diagnostic algorithm. Read More

Toxins (Basel) 2018 Nov 13;10(11). Epub 2018 Nov 13.

Department of Environmental Medicine, Poznan University of Medical Sciences, 60-806 Poznan, Poland.

Rhabdomyolysis, a condition associated with the consumption of Yellow Knight mushrooms (), was first reported in 2001. In response, some countries began to consider the mushroom as poisonous, whereas in others it is still consumed. In the present study, a nationwide survey of Polish mushroom foragers ( = 1545) was conducted to estimate the frequency of consumption. Read More

Carbohydr Polym 2019 Jan 29;204:142-151. Epub 2018 Sep 29.

College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address:

The present work investigated the antioxidative, anti-inflammatory and pulmonary protective effects of enzymatic- and acid- hydrolysed mycelia polysaccharides (En-MPS and Ac-MPS) from Oudemansiella radicata on LPS-induced acute lung injury (ALI) mice. The results demonstrated that both En-MPS and Ac-MPS showed potential pulmonary protective effects by decreasing serum levels of hs-CRP and C3, increasing pulmonary enzyme values of SOD, GSH-Px, CAT and the level of T-AOC; reducing the activity of MPO; and down-regulating the contents of MDA and LPO. In addition, the levels of TNF-ɑ, IL-1β, and IL-6 in BALF of mice treated with En-MPS at a dosage of 400 mg/kg/d were significantly lower than those in the ALI mice. Read More

Oxid Med Cell Longev 2018 30;2018:4285161. Epub 2018 Sep 30.

College of Life Science, Shandong Agricultural University, Tai'an 271018, China.

The aim of this work was to characterize spent mushroom substrate polysaccharides (MSP) from and their antioxidant and organ protective effects in streptozotocin- (STZ-) induced diabetic mice. The enzymatic-, acidic-, and alkalic- (En-, Ac-, and Al-) MSP were extracted from with snailase (4%), hydrochloric acid (1 mol/l), and sodium hydroxide (1 mol/l), respectively. The characterizations were evaluated by spectral analysis. Read More

Sci Total Environ 2019 Feb 22;651(Pt 1):1344-1355. Epub 2018 Sep 22.

Geological Survey of Norway, P.O. Box 6315, Torgarden, N-7491 Trondheim, Norway.

Eight regional to continental scale datasets providing Cd concentrations in subsoil (C horizon or mineral soil collected at depth) and topsoil are used to compare the statistical distribution of Cd in the two soil layers. Topsoil is invariably enriched in Cd when compared to subsoil. When both horizons are mineral soil the concentration ratio Cd/Cd is 1. Read More

Food Chem Toxicol 2019 Jan 25;123:162-168. Epub 2018 Oct 25.

Triskelion B.V. (formerly TNO Triskelion B.V.), Zeist, the Netherlands.

A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as "AM-1"). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA, at dose levels up to 5000 μg/plate. In the micronucleus (MN) test using human lymphocytes, AM-1 did not show a statistically significant increase in the number of binucleated cells containing micronuclei when compared to concurrent control cultures at all time points and at any of the concentrations analyzed (up to 900 μg/ml of culture medium). Read More

Anal Chim Acta 2018 Dec 6;1040:128-135. Epub 2018 Aug 6.

Research Center for Biotechnology, Bioethics and Environment, Universidad Autónoma de Bucaramanga, Bucaramanga, 680003, Colombia.

The presence of phenol in industrial wastewater is an issue of great relevance for petrochemical and energy companies, among others. The high toxicity level of this substance requires polluting industries to continuously monitor the concentration of phenol in their wastewaters so as to comply with environmental regulations and to minimize environmental impact. This research work proposes the experimental development of an analytical method for "in situ" measurement of the concentration of phenol diluted in water, with application in Oil & Gas production wastewater monitoring. Read More

Int J Med Mushrooms 2018 ;20(9):809-823

Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.

Ganoderma lingzhi (reishi) (GL) is a widely used medicinal mushroom in the treatment of several diseases, including metabolic syndrome and cancer. We recently performed autodigestion of GL and found enhanced release of hypotensive peptides and immunomodulating beta-1,3-glucan. In the present study, we examined the protective effects of G. Read More

Int J Med Mushrooms 2018 ;20(8):761-774

Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.

Doxorubicin (DOX) is an anticancer drug used extensively to treat a variety of human malignancies. DOX chemotherapy often leads to serious cardiotoxicity. We examined the ability of a Ganoderma lucidum extract (GLE) to prevent DOX-associated cardiotoxicity. Read More

Int J Med Mushrooms 2018 ;20(8):749-759

Centre of Agriculture Research, Baghdad, Iraq.

In this study, the aqueous extracts of fruiting bodies of Psathyrella candolleana and Agaricus bisporus were assessed in vitro for their genotoxic potential. Extracts of these 2 fungi were tested with regard to their capacity to protect genetic material against DNA damage caused by the anticancer chemotherapy drug, doxorubicin. Using chromosomal aberration, micronucleus, and comet assays, the genotoxic and genoprotective potential of these 2 fungi was assessed using P. Read More

Microb Pathog 2018 Dec 10;125:431-437. Epub 2018 Oct 10.

College of Life Science and Technology, Dalian University, Liaoning, 116622, China. Electronic address:

The inflammatory cellular model of RAW264.7 cells induced by lipopolysaccharide (LPS) has always been used to investigate the effect of anti-inflammatory agents in vitro. In the present study, the anti-inflammatory activity of total flavones extracted from the fermentation broth of the co-culture of Coprinus comatus and Morchella esculenta (MCF-F), and its potential molecular mechanism in LPS-challenged RAW264. Read More

J Biomol Struct Dyn 2018 Oct 6:1-51. Epub 2018 Oct 6.

a Department of Biotechnology , North Orissa University , Baripada , Odisha - 757003 India.

Hispolon is a polyphenolic compound derived from black hoof mushroom (Phellinus linteus) or shaggy bracket mushroom (Inonotus hispidus) which induces the inhibition of cancer promoting NF-κβ complex. To develop more potent lead molecules with enhanced anticancer efficiency, mechanism of hispolon mediated Nuclear Factor-κβ inhibition has been investigated by molecular modelling and docking. Ten derivatives of hispolon (DRG1-10) have been developed by pharmacophore based design with a view to enhance the anticancer efficacy. Read More

Carbohydr Polym 2018 Dec 26;201:566-574. Epub 2018 Aug 26.

College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address:

The synergistical action of inflammation response with oxidative stress has been reported to be response for the pathogenesis of lipopolysaccharide (LPS)-induced lung damage. In our present work, the antioxidative and anti-inflammatory efficacies of mycelia selenium polysaccharides (MSPS) from Hypsizigus marmoreus SK-03 in LPS-induced lung damaged mice, and its structure characterizations had been evaluated and analyzed. The animal investigations indicated that MSPS markedly ameliorated pulmonary injuries by the regulations of related inflammatory events via the observably antioxidant effects at the dose of 800 mg/kg. Read More

J Photochem Photobiol B 2018 Nov 22;188:42-49. Epub 2018 Aug 22.

Laser Spectroscopy and Nanomaterials Lab, Department of Physics, University of Allahabad, Allahabad, India. Electronic address:

It is highly desirable to discover novel green synthesis methods for cheap and scalable synthesis of nanoparticles (NPs) to reduce the negative impact on the environment. But these approaches generally impose great challenge in controlling size, shape, and homogeneity of product NPs. Here in the present study, we report a novel approach enabling direct sunlight and oyster mushroom (Pleurotus citrinopileatus) extract for the photo-biochemical synthesis of Ag NPs. Read More

J Psychopharmacol 2018 Dec 5;32(12):1286-1294. Epub 2018 Sep 5.

Maryland Poison Center, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD, USA.

Background:: Lysergic acid diethylamide (LSD) and psilocybin are serotonergic hallucinogens that are used primarily for recreational abuse. Small studies evaluated the efficacy of LSD and psilocybin for several psychiatric conditions. There are limited safety or toxicity data for either of these substances, especially in large populations. Read More

Int J Biol Macromol 2018 Dec 24;120(Pt A):811-822. Epub 2018 Aug 24.

College of Life Science, Shandong Agricultural University, Taian 271018, PR China. Electronic address:

The present work investigated the antioxidative, anti-inflammatory and organ protective effects of residue polysaccharide (RPS) and its enzymatic-RPS (ERPS) of Lentinula edodes against the LPS-induced sepsis in mice. The results demonstrated that ERPS showed superior effects on inhibiting serum activities of CKMB, LDH, AST, ALP and ALT, lowing the serum levels of BUN, CRE and UA, as well as improving the antioxidant status (SOD, CAT, GSH-P and T-AOC) than RPS. Moreover, the levels of TNF-α (667. Read More

Behav Brain Res 2019 01 14;356:18-40. Epub 2018 Aug 14.

Institute of Pharmacy, Nirma University, S. G. Highway, Ahmedabad, Gujarat, 382481, India. Electronic address:

Alzheimer's disease (AD) is an enervating and chronic progressive neurodegenerative disorder, occurring frequently in the elderly and adversely affecting intellectual capabilities and the cognitive processes. Bergenin possesses efficacious antioxidant, antiulcerogenic, anti-HIV, hepatoprotective, neuroprotective, anti-inflammatory and immunomodulatory activity along with antinociceptive effect and wound healing properties. Previous studies have shown that bergenin has in vitro bovine adrenal tyrosine hydroxylase inhibitory activity, mushroom tyrosinase inhibitory activities, β-secretase (BACE-1) enzyme inhibitory activity and prevented neuronal death in the primary culture of rat cortical neurons. Read More

Toxicol Lett 2018 Oct 11;296:95-104. Epub 2018 Aug 11.

School of Pharmacy, Xi'an Jiaotong University, 76(#) Yanta West Road, Xi'an 710061, Shaanxi, PR China; School of Forensic Science and Medicine, Xi'an Jiaotong University Health Science Center, 76(#) Yanta West Road, Xi'an 710061, Shaanxi, PR China. Electronic address:

Rapid and accurate identification of multiple toxins for clinical diagnosis and treatment of mushroom poisoning cases is still a challenge, especially with the lack of authentic references. In this study, we developed an effective method for simultaneous identification of amanita peptide toxins by liquid chromatography coupled with photodiode array detection and ion trap time-of-flight mass spectrometry. The accuracy and selectivity of the methodology were validated through similar multiple fragmentation patterns and characteristic ions of standard α- and β-amanitin. Read More

Environ Sci Pollut Res Int 2018 Oct 3;25(28):28216-28225. Epub 2018 Aug 3.

College of Resources and Environmental Science, Northeast Agricultural University, Harbin, 150030, People's Republic of China.

Heavy metal accumulation in plants may imperil human health. Inoculation of plant growth-promoting bacteria can alleviate the toxicity of heavy metal and promote plant growth. In this study, Bacillus sp. Read More