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Curr Issues Mol Biol 2022 Feb 22;44(3):1012-1026. Epub 2022 Feb 22.

Laboratory of Cell Signaling, Department of Microbiology, College of Natural Science, Pukyong National University, 45 Yongso-ro, Nam-Gu, Busan 48513, Korea.

Cancer is currently one of the foremost health challenges and a leading cause of death worldwide. Cervical cancer is caused by cofactors, including oral contraceptive use, smoking, multiparity, and HIV infection. One of the major and considerable etiologies is the persistent infection of the oncogenic human papilloma virus. Read More

Oxid Med Cell Longev 2022 1;2022:9266178. Epub 2022 Jun 1.

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Clinical outcomes for doxorubicin (Dox) are limited by its cardiotoxicity but a combination of Dox and agents with cardioprotective activities is an effective strategy to improve its therapeutic outcome. Natural products provide abundant resources to search for novel cardioprotective agents. (GL) is the most well-known edible mushroom within the family. Read More

Front Mol Biosci 2022 25;9:902706. Epub 2022 May 25.

Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Ostreolysin A6 (OlyA6) is a 15 kDa protein produced by the oyster mushroom (). It belongs to the aegerolysin family of proteins and binds with high affinity to the insect-specific membrane sphingolipid, ceramide phosphoethanolamine (CPE). In concert with its partnering protein with the membrane-attack-complex/perforin domain, pleurotolysin B (PlyB), OlyA6 can form bicomponent 13-meric transmembrane pores in artificial and biological membranes containing the aegerolysin lipid receptor, CPE. Read More

Pharm Biol 2022 Dec;60(1):1126-1136

Department of Medical Laboratory of Technology, Bina Cipta Husada College of Health Science, Central Java, Indonesia.

Context: Edible mushrooms have a long history of use in traditional Chinese or Japanese medicine. (O.F. Read More

Food Chem Toxicol 2022 Jun 6;166:113198. Epub 2022 Jun 6.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal; Laboratório Associado i4HB - Instituto para a Saúde e a Bioeconomia, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313, Porto, Portugal. Electronic address:

Amanita phalloides is one of the most toxic mushrooms worldwide, being responsible for the majority of human fatal cases of mushroom intoxications. α-Amanitin, the most deleterious toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and renal failure. Read More

Wilderness Environ Med 2022 May 16. Epub 2022 May 16.

Department of Emergency Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Mushroom poisoning and subsequently the number of patients visiting emergency rooms are increasing, as well as the proportion of fatal mushroom poisonings. Myocytic mushroom poisoning is one of the new clinical classifications. This report documents the course of a family with Russula subnigricans poisoning complicated by severe rhabdomyolysis, including a case that was misdiagnosed as myocardial infarction. Read More

Food Funct 2022 May 23;13(10):5794-5806. Epub 2022 May 23.

College of Life Science, Shandong Agricultural University, No. 61, Daizong Street, Taian, Shandong, 271018, PR China.

Nonylphenol (NP) exposure has become a crucial inducement of male reproductive disorders in the world. Therefore, it is urgent to seek solutions to alleviate the toxicity of NP. This study was oriented toward studying the protective effects of mycelium polysaccharides (MMP) on NP-induced reproductive impairments. Read More

Chemosphere 2021 Jun 13;272:129855. Epub 2021 Feb 13.

Faculty of Sciences, Earth and Environmental Sciences, Department F.-A. Forel for Environmental and Aquatic Sciences, University of Geneva, Uni Carl Vogt, 66 Bvd. Carl Vogt, CH-1211, Geneva, Switzerland. Electronic address:

The microbial community composition in aquatic ecosystems have received increased attention. However, the knowledge gap relative to the responses of bacterial, archaeal and fungal communities in co-contaminated river sediments remain poorly studied. Here, we investigated the changes of tetrabromobisphenol A (TBBPA) and copper (Cu) concentrations and the responses of microbial communities in co-contaminated sediments during long-term incubation. Read More

Science 2022 05 5;376(6593):644-648. Epub 2022 May 5.

Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, USA.

The reported toxicity of oxybenzone-based sunscreens to corals has raised concerns about the impacts of ecotourist-shed sunscreens on corals already weakened by global stressors. However, oxybenzone's toxicity mechanism(s) are not understood, hampering development of safer sunscreens. We found that oxybenzone caused high mortality of a sea anemone under simulated sunlight including ultraviolet (UV) radiation (290 to 370 nanometers). Read More

Toxicon 2022 Jul 30;214:1-7. Epub 2022 Apr 30.

Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, 21163, Jordan.

Mushroom poisoning is a worldwide public health problem that may cause serious toxic consequences on renal functions. The study aimed to evaluate the acute toxicity (24 h) of orellanine (OR) from Cortinarius orellanus in rat kidney and the ameliorative effect of parsley ethanolic extract. Twelve adult male Wistar rats were used to determine intraperitoneal (ip) median lethal dose (LD) of OR, and 32 rats were divided into 4 groups (n = 8): OR group had 500 mg OR per kg bwt; OR + parsley group had the same dose of OR and after 1 h had 500 mg/kg parsley orally; parsley group had parsley only; and control had the vehicle 0. Read More

Int J Med Mushrooms 2022 ;24(3):35-50

Institute of Biological Sciences, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia; Mushroom Research Centre, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

Neurological diseases are increasingly recognized as a health burden worldwide, mainly affecting the elderly population. Sanguinoderma rugosum (=Amauroderma rugosum) is a wild medicinal mushroom traditionally used to alleviate inflammation and prevent seizures. The present study aimed to investigate the neuroprotective and neurorescue effects as well as the possible mechanisms of S. Read More

Evid Based Complement Alternat Med 2022 12;2022:8198859. Epub 2022 Apr 12.

Laboratory of Phytoprotection and Valorization of Genetic Resources, Biotechnology Centre, Nkolbisson, University of Yaoundé 1, P.O. Box 17673, Etetak, Yaoundé, Cameroon.

Hepatocellular carcinoma (HCC) is one of the most common and lethal diseases worldwide. Its treatment remains ineffective and the prognosis remains severe, thus favoring the emergence of a preventive approach. Mushroom-derived polysaccharides offer great opportunities because of their less toxicity and bioactivities. Read More

ACS Nano 2022 Apr 22. Epub 2022 Apr 22.

Departments of Diagnostic Radiology and Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.

The key to controlling the spread of the coronavirus disease 2019 (COVID-19) and reducing mortality is highly dependent on the safe and effective use of vaccines for the general population. Current COVID-19 vaccination practices (intramuscular injection of solution-based vaccines) are limited by heavy reliance on medical professionals, poor compliance, and laborious vaccination recording procedures, resulting in a waste of health resources and low vaccination coverage, In this study, we developed a smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle platform for the effective and convenient delivery of multidose COVID-19 vaccines and decentralized vaccine information storage. The mushroom-like structure allows the MILD system to be easily pressed into the skin and detached from the patch base, acting as a "tattoo" to record the vaccine counts without any storage equipment, offering quick accessibility and effortless readout, saving a great deal of valuable time and energy for both patients and health professionals. Read More

Int J Med Mushrooms 2022 ;24(2):31-40

Sahyadri Bio Labs Pvt, Ltd., Pannissery, Koonammoochy P.O, Thrissur - 680504, Kerala, India; Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, Kerala, India.

This study aimed to evaluate the effect of the polysaccharide-protein complex isolated from the fruiting bodies (GLFPPC) and cultured mycelia (GLMPPC) of a highly valued medicinal mushroom, Ganoderma lucidum, to alleviate doxorubicin (DOX)-induced cardiotoxicity. GLFPPC and GLMPPC were isolated from aqueous-alcoholic extracts of fruiting bodies and cultured mycelia of G. lucidum by repeated ethanol precipitation, dialysis, treatment with Sevag reagent, and freeze drying. Read More

Int J Med Mushrooms 2022 ;24(2):23-30

Federal State Research Institution, State Research Center of Virology and Biotechnology Vector of the Federal Service for Surveillance in Consumer Rights Protection and Human Wellbeing, Novosibirsk Region, Russia.

The antiviral properties of water extracts from pharmaceutical raw materials of the chaga mushroom, Inonotus obliquus, were studied against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All studies with infectious materials were carried out in an isolated virological laboratory of the State Research Center of Virology and Biotechnology Vector of Rospotrebnadzor, which has a sanitary and epidemiological conclusion for the right to work with pathogenic biological agents of I-II pathogenicity groups. Antiviral activity was determined by the ability of I. Read More

Am J Cancer Res 2022 15;12(3):1282-1294. Epub 2022 Mar 15.

Department of Biochemistry, Universidad Central del Caribe Bayamón, Puerto Rico, USA.

Inflammatory Breast Cancer (IBC) is a rare and aggressive type of breast cancer with a poor prognosis. Its management is challenging because of a lack of targeted therapies, increased metastatic potential, and high recurrence rates. Interest in using platinum agents such as carboplatin emerged from data suggesting frequent DNA repair defects in breast cancer. Read More

Biochem Biophys Res Commun 2022 06 23;608:108-115. Epub 2022 Mar 23.

Department of Oncology, The Jiangjin District Central Hospital, Chongqing, 402260, China. Electronic address:

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer with poor clinical outcome. Poricoic acid A (PAA) is the main chemical constituent on the surface layer of the mushroom Poria cocos, and exerts protective effects against various diseases. In the study, its effects on T-ALL progression were investigated both in vitro and in vivo. Read More

Drug Deliv 2022 Dec;29(1):997-1006

Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Gold nanoparticles (AuNPs) were successfully fabricated by polysaccharide (PAP-1a) without employing any other chemicals. The physical and chemical properties of PAP-AuNPs were determined using transmission electron microscopy (TEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDXR), Fourier-transform infrared spectroscopy (FT-IR), and atomic force microscopy (AFM). In an attempt to analyze the immune regulation, antitumor effect, and biological safety, the production of NO and TNF-α, IL-12p70, and IL-1β from RAW264. Read More

J Toxicol Environ Health A 2022 Jul 31;85(14):573-585. Epub 2022 Mar 31.

Oxidative Stress and Cell Signaling Research Group, Centro Interdisciplinar em Biotecnologia - CIPBIOTEC, Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, Brazil.

Fungal pollution of indoor environments contributes to several allergic symptoms and represents a public health problem. It is well-established that 1-octen-3-ol, also known as mushroom alcohol, is a fungal volatile organic compound (VOC) commonly found in damp indoor spaces and responsible for the typical musty odor. Previously it was reported that exposure to 1-octen-3-ol induced inflammations and disrupted mitochondrial morphology and bioenergetic rate in . Read More

Curr Res Toxicol 2022 11;3:100068. Epub 2022 Mar 11.

Brincor Associates LLC., 6056 Haybury Drive, New Albany, OH 43054, USA.

The medicinal effects of have been long documented in scientific studies of Eastern traditional medicine It is widely consumed, because of its nutritional qualities and perceived health benefits. Also, it is rich in β-glucans, which has been shown to have immunomodulating and antitumor effects. The objective of the present study was to investigate adverse effects, if any, of β-glucan extract preparation from in subchronic toxicity and genotoxicity studies. Read More

Appl Microbiol Biotechnol 2022 Apr 26;106(7):2677-2688. Epub 2022 Mar 26.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences/Key Laboratory of Microbial Resources Collection and Preservation, Ministry of Agriculture and Rural Affairs, Beijing, 100081, China.

Lentinula edodes is one of the most important commercially cultivated edible mushrooms. It is well known that gypsum (CaSO·2HO) supplementation in sawdust medium increases the yield of L. edodes, while the physiological mechanisms remain unclear. Read More

J Anal Toxicol 2022 Mar 16. Epub 2022 Mar 16.

Laboratory LAT LUMTOX, 07800 La Voulte sur Rhône, France.

Consumption of mushrooms can become unsafe for the consumer in case of confusion. It is the case of some fungi of the Cortinarius genus, which contain the nephrotoxic mycotoxin orellanine responsible for their toxicity. Related case poisoning diagnosis is a challenge for both clinicians and analysts because of a long latency period between intake and toxic syndrome, the lack of available information in literature and the numerous pitfalls of orellanine identification/quantification in biological samples. Read More

J Hazard Mater 2022 06 4;431:128625. Epub 2022 Mar 4.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

Decabromodiphenyl ethane (DBDPE), one widely used new brominated flame retardant, was of great concern due to its biotoxicity. The toxic evaluation of DBDPE (1-50 mg/L) to white-rot fungus (Pleurotus ostreatus), including oxidative stress, morphology and transcriptomics was conducted aiming at improving its biodegradation. Fungal growth and ATPase activity were obviously inhibited by DBDPE at ≥ 10 mg/L with the exposure from 48 h to 96 h. Read More

FASEB J 2022 04;36(4):e22215

Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.

Clitocybe nebularis lectin (CNL) is a GalNAcβ1-4GlcNAc-binding lectin that exhibits an antiproliferative effect exclusively on the Jurkat leukemic T cell line by provoking homotypic aggregation and dose-dependent cell death. Cell death of Jurkat cells exhibited typical features of early apoptosis, but lacked the activation of initiating and executing caspases. None of the features of CNL-induced cell death were effectively blocked with the pan-caspase inhibitor or different cysteine peptidase inhibitors. Read More

Steroids 2022 05 23;181:108990. Epub 2022 Feb 23.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan; H. E. J. Research Institute of Chemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi 75270, Pakistan.

Sarcosphaera crassa is a mushroom consumed in Europe and Anatolia after being cooked well. The cytotoxic activity of the extracts of unbaked S. crassa against MCF7, HT29, HeLa cancer cell lines and toxicity against PDF fibroblast healthy cell lines were studied using MTT assay. Read More

Viruses 2022 02 10;14(2). Epub 2022 Feb 10.

Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia.

To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom ( L., Linn. var. Read More

Eur J Med Chem 2022 Mar 29;231:114147. Epub 2022 Jan 29.

Department of Woman's and Child's Health, Hemato-oncology Lab, University of Padova, 35131, Padova, Italy.

A novel series of twenty-seven cinnamides constituted by cinnamic acid derivatives liked to 1-aryl piperazines were synthesized and evaluated for their potential inhibitory diphenolase activity of mushroom tyrosinase. Among them, the presence of a 3-chloro-4-fluorophenyl moiety at the N-1 position of piperazine ring was essential for a potent tyrosinase inhibitory effect, with the 3-nitrocinnamoyl (19p) and 2-chloro-3-methoxycinnamoyl (19t) derivatives as the most potent compounds of the series, with IC of 0.16 and 0. Read More

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2022 Mar 3;39(3):508-524. Epub 2022 Feb 3.

Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, USA.

Mushrooms are bioaccumulators and have been used to produce Se-enriched foods. However, these fungi can also bioaccumulate potentially toxic metals, producing food dangerous to human health. It is known that co-exposure to Se plays a protective role against metal accumulation and toxicity in some organisms due to its antioxidant properties. Read More

Food Funct 2022 Feb 21;13(4):2057-2067. Epub 2022 Feb 21.

College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, People's Republic of China.

Polysaccharides have high antioxidant, hypoglycemic, hypolipidemic, hepatoprotective, anti-tumor, and anticancer activities. In this study, the ability of the fruiting body polysaccharide (LDFP) to protect against CCl-induced acute liver injury in mice by activating the Nrf2 pathway was studied. LDFP can inhibit the activity of ALT, AST, TC, TG, tumor necrosis factor (TNF-α), and interleukin-6 (IL-6) in serum; significantly improve the inflammatory state of the liver; increase the activity of superoxide dismutase (SOD) and the glutathione (GSH) content; decrease the malondialdehyde (MDA) content; alleviate the toxicity caused by reactive oxygen species; and alleviate liver injury. Read More

Biol Trace Elem Res 2022 Jan 26. Epub 2022 Jan 26.

Faculty of Science, Department of Biochemistry, Ain Shams University, Cairo, Egypt.

Zinc nanoparticles (Zn-NPs) have garnered a great deal of attention as potential cancer therapy. The use of microorganisms in the synthesis of nanoparticles emerges as an eco-friendly and exciting approach. This study was designed to assess biosynthesized Zn-NPs as therapeutic agent against kidney cancer induced by ferric-nitrilotriacetate (Fe-NTA) in rats. Read More