1,936 results match your criteria Toxicity Monoamine Oxidase Inhibitor


Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer's Disease.

Molecules 2020 Apr 1;25(7). Epub 2020 Apr 1.

University School of Biotechnology, Guru Gobind Singh Indraprastha University, Dwarka, Sector 16C, New Delhi 110075, India.

Alzheimer's disease (AD) is a multifactorial disorder characterized by exponential loss of memory and cognitive deficit involving several disease modifying targets (amyloid beta, beta-secretase, monoaminoxidase-B, and cholinesterase). The present study explores multi-target directed ligand approach using secondary metabolite reserpine (RES) and ajmalicine (AJM) obtained from roots. Novel LCMS and HPLC methods were developed for identification and quantification of reserpine and ajmalicine. Read More

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http://dx.doi.org/10.3390/molecules25071609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180484PMC

Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.

J Neural Transm (Vienna) 2020 Feb 28;127(2):131-147. Epub 2020 Jan 28.

Department of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin University, 12 Araike, Iwasaki-cho, Nissin, Aichi, 320-0195, Japan.

Parkinson's disease has been considered as a motor neuron disease with dopamine (DA) deficit caused by neuronal loss in the substantia nigra, but now proposed as a multi-system disorder associated with α-synuclein accumulation in neuronal and non-neuronal systems. Neuroprotection in Parkinson's disease has intended to halt or reverse cell death of nigro-striatal DA neurons and prevent the disease progression, but clinical studies have not presented enough beneficial results, except the trial of rasagiline by delayed start design at low dose of 1 mg/day only. Now strategy of disease-modifying therapy should be reconsidered taking consideration of accumulation and toxicity of α-synuclein preceding the manifest of motor symptoms. Read More

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http://dx.doi.org/10.1007/s00702-020-02150-wDOI Listing
February 2020

The catecholaldehyde hypothesis: where MAO fits in.

J Neural Transm (Vienna) 2020 Feb 5;127(2):169-177. Epub 2019 Dec 5.

Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological, Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892-1620, USA.

Monoamine oxidase (MAO) plays a central role in the metabolism of the neurotransmitters dopamine, norepinephrine, and serotonin. This brief review focuses on 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is the immediate product of MAO acting on cytoplasmic dopamine. DOPAL is toxic; however, normally DOPAL is converted via aldehyde dehydrogenase (ALDH) to 3,4-dihydroxyphenylacetic acid (DOPAC), which rapidly exits the neurons. Read More

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http://dx.doi.org/10.1007/s00702-019-02106-9DOI Listing
February 2020

Establishment of resveratrol and its derivatives as neuroprotectant against monocrotophos-induced alteration in NIPBL and POU4F1 protein through molecular docking studies.

Environ Sci Pollut Res Int 2020 Jan 30;27(1):291-304. Epub 2019 Nov 30.

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, U.P., India.

Monocrotophos (MCP) is a broad spectrum organophosphorus insecticide, which is widely used as foliar spray to the different important crops. MCP may reach the soil and the aquatic environment directly or indirectly during and after the application, which leads to the different environmental issues. MCP is found to be associated with neurotoxicity and its toxic effects have been monitored during different stages of neuronal development. Read More

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http://dx.doi.org/10.1007/s11356-019-06806-3DOI Listing
January 2020

Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.

Eur J Med Chem 2020 Jan 16;185:111770. Epub 2019 Oct 16.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal. Electronic address:

Piperine has been associated with neuroprotective effects and monoamine oxidase (MAO) inhibition, thus being an attractive scaffold to develop new antiparkinsonian agents. Accordingly, we prepared a small library of piperine derivatives and screened the inhibitory activities towards human MAO isoforms (hMAO-A and hMAO-B). Structure-activity relationship (SAR) studies pointed out that the combination of α-cyano and benzyl ester groups increased both potency and selectivity towards hMAO-B. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.111770DOI Listing
January 2020

Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review.

Medicines (Basel) 2019 Oct 18;6(4). Epub 2019 Oct 18.

Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior (CICS-UBI), 6200-506 Covilhã, Portugal.

Ayahuasca is a psychoactive beverage prepared traditionally from a mixture of the leaves and stems of and , respectively, being originally consumed by indigenous Amazonian tribes for ritual and medicinal purposes. Over the years, its use has spread to other populations as a means to personal growth and spiritual connection. Also, the recreational use of its isolated compounds has become prominent. Read More

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http://dx.doi.org/10.3390/medicines6040106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963515PMC
October 2019
1 Read

Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation.

Life Sci 2019 Nov 11;237:116954. Epub 2019 Oct 11.

Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Sirt3 enzyme and mitochondrial abnormality can be related to excess fatigue or muscular dysfunction in multiple sclerosis (MS).Ellagic acid (EA) has a mitochondrial protector, iron chelator, antioxidant, and axon regenerator in neurons.In this study the effect of EAon muscle dysfunction, its mitochondria, and Sirt3 enzyme incuprizone-induced model of MSwas examined. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.116954DOI Listing
November 2019
2.702 Impact Factor

Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions.

Int J Tryptophan Res 2019 9;12:1178646919873925. Epub 2019 Sep 9.

Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Serotonin syndrome (SS) (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in both the peripheral (PNS) and central nervous systems (CNS). It is characterised by a dose-relevant spectrum of clinical findings related to the level of free serotonin (5-hydroxytryptamine [5-HT]), or 5-HT receptor activation (predominantly the 5-HT and 5-HT subtypes), which include neuromuscular abnormalities, autonomic hyperactivity, and mental state changes. Severe SS is only usually precipitated by the simultaneous initiation of 2 or more serotonergic drugs, but the syndrome can also occur after the initiation of a single serotonergic drug in a susceptible individual, the addition of a second or third agent to long-standing doses of a maintenance serotonergic drug, or after an overdose. Read More

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http://dx.doi.org/10.1177/1178646919873925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734608PMC
September 2019
3 Reads

Stereological Investigation of Regional Brain Volumes after Acute and Chronic Cuprizone-Induced Demyelination.

Cells 2019 09 3;8(9). Epub 2019 Sep 3.

Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.

Brain volume measurement is one of the most frequently used biomarkers to establish neuroprotective effects during pre-clinical multiple sclerosis (MS) studies. Furthermore, whole-brain atrophy estimates in MS correlate more robustly with clinical disability than traditional, lesion-based metrics. However, the underlying mechanisms leading to brain atrophy are poorly understood, partly due to the lack of appropriate animal models to study this aspect of the disease. Read More

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http://dx.doi.org/10.3390/cells8091024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770802PMC
September 2019
1 Read

Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study.

ACS Omega 2019 Jul 3;4(7):11621-11630. Epub 2019 Jul 3.

Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.

A number of nature-derived biologically active compounds comprise glycosides. In some cases, the glycosidic residue is needed for bioactivity; however, in other cases, glycosylation just improves some pharmacokinetic/dynamic parameters. The patterns of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibition by rubrofusarin 6--β-d-glucopyranoside (), rubrofusarin 6--β-d-gentiobioside (), rubrofusarin triglucoside (), and cassiaside B2 () were compared with the aglycone, rubrofusarin, isolated from seeds. Read More

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http://dx.doi.org/10.1021/acsomega.9b01433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682096PMC
July 2019
3 Reads

The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson's Disease (PD).

Cells 2019 08 16;8(8). Epub 2019 Aug 16.

Department of Research, National Neuroscience Institute, Singapore 308433, Singapore.

Accumulative evidence indicated that the pathologically accumulated metal ions (iron species and Mn) and abnormally up-regulated monoamine oxidase B (MAOB) activity induced oxidation of endogenous dopamine (DA) can lead to mitochondria impairment, lysosome dysfunction, proteasome inhibition, and selective DA neuron vulnerability, which is implicated in the pathogenesis of Parkinson's disease (PD). The DA oxidation can generate deleterious reactive oxygen species (ROS) and highly reactive DA quinones (DAQ) to induce DA-related toxicity, which can be alleviated by DA oxidation suppressors, ROS scavengers, DAQ quenchers, and MAOB inhibitors. On the other hand, the nuclear factor erythroid 2-related factor 2 (Nrf2)-Keap1 and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) anti-oxidative and proliferative signaling pathways play roles in anti-oxidative cell defense and mitochondria biogenesis, which is implicated in DA neuron protections. Read More

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http://dx.doi.org/10.3390/cells8080911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721683PMC
August 2019
4 Reads

Butyrate suppresses demyelination and enhances remyelination.

J Neuroinflammation 2019 Aug 9;16(1):165. Epub 2019 Aug 9.

Department of Immunology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.

Background: The association of gut microbiota and diseases of the central nervous system (CNS), including multiple sclerosis (MS), has attracted much attention. Although a previous analysis of MS gut microbiota revealed a reduction in species producing short-chain fatty acids (SCFAs), the influence of these metabolites on demyelination and remyelination, the critical factors of MS pathogenesis, remains unclear.

Methods: To investigate the relationship between demyelination and gut microbiota, we administered a mixture of non-absorbing antibiotics or SCFAs to mice with cuprizone-induced demyelination and evaluated demyelination and the accumulation of microglia. Read More

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http://dx.doi.org/10.1186/s12974-019-1552-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688239PMC
August 2019
3 Reads

Monoamine oxidase A inhibition by toxic concentrations of metaxalone.

Clin Toxicol (Phila) 2020 May 2;58(5):383-387. Epub 2019 Aug 2.

Upstate New York Poison Center, Syracuse, NY, USA.

Serotonin toxicity is a reported complication associated with both therapeutic use and overdose of metaxalone while on therapeutic doses of serotonergic drugs such as serotonin reuptake inhibitors. Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrations reported with cases of serotonin toxicity range from 31 to 61 mcg/ml (140-276 µM). Read More

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http://dx.doi.org/10.1080/15563650.2019.1648815DOI Listing
May 2020
6 Reads

Fatal monocrotophos poisoning by cutaneous absorption while sleeping: A remarkable case study.

Med Leg J 2019 Sep 29;87(3):144-150. Epub 2019 Jul 29.

Delhi State Forensic Science Laboratory, India.

Organophosphate poisoning is a continued menace associated with high morbidity and mortality in both resource-crunched developing and developed countries. Cases have been described of deliberate self-poisoning which has higher mortality than accidental exposure. Fatal poisoning by accidental dermal absorption is rarely reported for monocrotophos. Read More

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http://dx.doi.org/10.1177/0025817219853455DOI Listing
September 2019
5 Reads

The effects of tranylcypromine on osteoclastogenesis and .

FASEB J 2019 09 10;33(9):9828-9841. Epub 2019 Jul 10.

Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Identification of anti-osteoclastogenic agents is important for the treatment of bone loss diseases that feature excessive osteoclast (OC) activity and bone resorption. Tranylcypromine (TCP), an irreversible inhibitor of monoamine oxidase (MAO), has been used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders. TCP has been discovered to exert anabolic effect on osteoblasts, and MAO-A has also been verified as an important mediator in prostate cancer cells to accelerate osteoclastogenesis. Read More

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http://dx.doi.org/10.1096/fj.201802242RRDOI Listing
September 2019
3 Reads
5.043 Impact Factor

Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.

Eur J Med Chem 2019 Sep 16;177:221-234. Epub 2019 May 16.

Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India. Electronic address:

Alzheimer's disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years' different pharmacological strategies including multi-targeting agents are being explored for the effective drug development for AD. A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.05.039DOI Listing
September 2019
5 Reads
3.447 Impact Factor

Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In-vitro Neuroprotective and MAO-B Inhibitory Activities.

Med Chem 2020 ;16(3):326-339

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.

Objective: The syntheses and biological activities of 8-thiosubstituted-1,3,7- trimethylxanthine derivatives bearing an aromatic hydrazide-hydrazone fragment in the side chain at C8 are described.

Methods: The chemical structures of the synthesized compounds 6a-m were confirmed based on their MS, FTIR, 1H NMR and 13C NMR analyses.

Results: The in vitro investigations of neuroprotective effects manifested on cellular (human neuroblastoma cell line SH-SY5Y) and sub-cellular (isolated rat brain synaptosomes) levels show that compounds 6g and 6i demonstrate statistically significant activity. Read More

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http://dx.doi.org/10.2174/1573406415666190531121927DOI Listing
January 2020
9 Reads

Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination.

Neurobiol Dis 2019 09 14;129:102-117. Epub 2019 May 14.

Synaptic Immunopathology Lab, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Growing data from human and animal studies indicate the beneficial effects of exercise on several clinical outcomes in patients with multiple sclerosis (MS), an autoimmune, demyelinating disease, suggesting that it may slow down the disease progression, by reducing brain damage. However, the mechanisms involved are still elusive. Aim of this study was to address the effects of voluntary running wheel in a toxic-demyelinating model of MS, in which demyelination and brain inflammation occur in response to cuprizone (CPZ) treatment. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.05.010DOI Listing
September 2019
2 Reads
5.078 Impact Factor

Relationship of Iron Metabolism and Short-Term Cuprizone Treatment of C57BL/6 Mice.

Int J Mol Sci 2019 May 7;20(9). Epub 2019 May 7.

Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary.

One of the models to investigate the distinct mechanisms contributing to neurodegeneration in multiple sclerosis is based on cuprizone (CZ) intoxication. CZ is toxic to mature oligodendrocytes and produces demyelination within the central nervous system but does not cause direct neuronal damage. The CZ model is suitable for better understanding the molecular mechanism of de- and remyelination processes of oligodendrocytes. Read More

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http://dx.doi.org/10.3390/ijms20092257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539941PMC
May 2019
3 Reads

Harmine shows therapeutic activity on nicotine-induced liver failure in mice.

Histol Histopathol 2019 Oct 3;34(10):1185-1193. Epub 2019 May 3.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

This experiment evaluated the effects of harmine against nicotine-induced damage to the liver of mice. Nicotine is a major toxic component of cigarette smoke and a major risk factor for functional disorders in the liver, because it induces oxidative stress. Harmine is a harmal-derived alkaloid with therapeutic and antioxidant properties. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18122.htm
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http://dx.doi.org/10.14670/HH-18-122DOI Listing
October 2019
173 Reads
2.096 Impact Factor

Neuroprotective effect of -acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation.

Drug Des Devel Ther 2019 11;13:1155-1162. Epub 2019 Apr 11.

Department of Zoology, Faculty of Science, University of Alexandria, Alexandria, Egypt,

Background: Neurotoxicity is a major obstacle to the effectiveness of cisplatin (CDDP) in cancer chemotherapy. Oxidative stress and inflammation are considered to be the major mechanisms involved in CDDP-induced neurotoxicity. The rationale of our study was to investigate the efficacy of -acetylcysteine (NAC) at two different doses in the management of CDDP-induced toxicity in rat brain by monitoring its antioxidant and anti-inflammatory effects. Read More

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http://dx.doi.org/10.2147/DDDT.S191240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469471PMC
September 2019
1 Read

Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [F]DPA-714 PET and MRI.

Theranostics 2019 20;9(6):1523-1537. Epub 2019 Feb 20.

European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.

: Activation and dysregulation of innate, adaptive and resident immune cells in response to damage determine the pathophysiology of demyelinating disorders. Among the plethora of involved cells, microglia/macrophages and astrocytes play an important role in the pathogenesis of demyelinating disorders. The in-depth investigation of the spatio-temporal profile of these cell types may inform about the exact disease state and localization as well as may allow to monitor therapeutic modulation of the components of the neuroinflammatory response during the course of multiple sclerosis (MS). Read More

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http://dx.doi.org/10.7150/thno.32461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485187PMC
March 2020
1 Read

Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.

J Mol Histol 2019 Jun 23;50(3):263-271. Epub 2019 Apr 23.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Oxidative stress with mitochondrial defects has a central role in the development and deterioration of Multiple sclerosis (MS). According to new findings of the effects of metformin on mitochondrial function, has attracted a lot of attention. Furthermore, it is suggested that metformin exerts its beneficial influence through AMP-activated protein kinase (AMPK) pathway. Read More

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http://link.springer.com/10.1007/s10735-019-09824-0
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http://dx.doi.org/10.1007/s10735-019-09824-0DOI Listing
June 2019
4 Reads

Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice.

Histochem Cell Biol 2019 Aug 23;152(2):119-131. Epub 2019 Apr 23.

Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057, Rostock, Germany.

Oligodendrocyte degeneration is a hallmark of multiple sclerosis pathology, and protecting oligodendrocytes and myelin is likely to be of clinical relevance. Traditionally, oligodendrocyte and myelin degeneration are viewed as a direct consequence of an inflammatory attack, but metabolic defects might be equally important. Appropriate animal models to study the interplay of inflammation and metabolic injury are, therefore, needed. Read More

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http://dx.doi.org/10.1007/s00418-019-01786-4DOI Listing
August 2019
4 Reads

Potential Pharmacokinetic Drug⁻Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive -Methyl-d-Aspartate Receptor Antagonist.

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rood, Shanghai 201203, China.

Harmine (HAR) is a beta-carboline alkaloid widely distributed in nature. It exhibits psychopharmacological effects of improving learning and memory. However, excessive dose of HAR can cause central tremor toxicity, which may be related to the glutamate system. Read More

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http://dx.doi.org/10.3390/molecules24071430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479946PMC
April 2019
6 Reads

Pathological changes in mice with long term cuprizone administration.

Neurochem Int 2019 06 30;126:229-238. Epub 2019 Mar 30.

Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In MS, a long disease duration is known to be a strong risk factor for converting the clinical course of the disease from relapse remitting MS to secondary progressing MS. There is a hypothesis that long sustained demyelination may exhaust neurons, however, pathological changes induced in neurons following demyelination remain unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186193005
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http://dx.doi.org/10.1016/j.neuint.2019.03.018DOI Listing
June 2019
15 Reads

Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination.

J Mol Neurosci 2019 Aug 2;68(4):522-528. Epub 2019 Apr 2.

Institute of Anatomy, Rostock University Medical Center, 18057, Rostock, Germany.

An elegant model to study mechanisms operant during oligodendrocyte degeneration and subsequent demyelination is the cuprizone model. In that model, mice are intoxicated with the copper chelation agent cuprizone which results in early oligodendrocyte stress, oligodendrocyte apoptosis, and, finally, demyelination. Here, we systematically investigated to what extent the animals' weight at the beginning of the cuprizone intoxication period is critical for the reproducibility of the cuprizone-induced pathology. Read More

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http://dx.doi.org/10.1007/s12031-019-01312-0DOI Listing
August 2019
1 Read

Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain.

Neurochem Int 2019 06 10;126:139-153. Epub 2019 Mar 10.

Institute of Anatomy, Medical University of Rostock, Rostock, Germany. Electronic address:

Brain-intrinsic degenerative cascades are a proposed factor driving inflammatory lesion formation in multiple sclerosis (MS) patients. We recently showed that encephalitogenic lymphocytes are recruited to the sites of active demyelination induced by cuprizone. Here, we investigated whether cuprizone-induced oligodendrocyte and myelin pathology is sufficient to trigger peripheral immune cell recruitment into the forebrain. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.03.005DOI Listing
June 2019
26 Reads

Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine.

Chem Biol Interact 2019 May 8;304:139-147. Epub 2019 Mar 8.

Department of Psychiatry (Neurochemical Research Unit), University of Alberta, Edmonton, Canada; Department of Medicine (Neurology), University of Alberta, Edmonton, Canada. Electronic address:

Phenelzine (β-phenylethylhydrazine) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic properties. It possesses a number of important pharmacological properties which may alter the effects of oxidative stress. After conducting a comprehensive literature search, the authors of this review paper aim to provide an overview and discussion of the mechanisms by which phenelzine may attenuate oxidative stress. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.003DOI Listing
May 2019
27 Reads

Syrian rue seeds interacted with acacia tree bark in an herbal stew resulted in N,N-dimethyltryptamine poisoning.

Clin Toxicol (Phila) 2019 Oct 4;57(10):867-869. Epub 2019 Mar 4.

d Department of Emergency Medicine, Chang Gung Memorial Hospital , Keelung , Taiwan.

Illicit substance use is an increasing problem all over the world, especially in adolescents and young adults. It is a challenge to make a definitive diagnosis of a specific substance in a poisoning case without toxicology laboratory confirmation. We confirmed the presence of N,N-dimethyltryptamine (DMT) by liquid chromatograph tandem mass spectrometer (LC/MS/MS) in biologic samples from two patients who presented with signs and symptoms consistent with sympathomimetic toxicity following the consumption of an herbal stew. Read More

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http://dx.doi.org/10.1080/15563650.2019.1576877DOI Listing
October 2019
27 Reads

Toxin-Based Models to Investigate Demyelination and Remyelination.

Methods Mol Biol 2019 ;1936:377-396

Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

Clinical myelin diseases, and our best experimental approximations, are complex entities in which demyelination and remyelination proceed unpredictably and concurrently. These features can make it difficult to identify mechanistic details. Toxin-based models offer lesions with predictable spatiotemporal patterns and relatively discrete phases of damage and repair: a simpler system to study the relevant biology and how this can be manipulated. Read More

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http://dx.doi.org/10.1007/978-1-4939-9072-6_21DOI Listing
July 2019
7 Reads

The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.

Mol Nutr Food Res 2019 05 27;63(10):e1801177. Epub 2019 Mar 27.

Department of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut (MRI), Federal Research Institute of Nutrition and Food, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany.

Scope: Heterocyclic aromatic amines (HAAs) are process-induced food contaminants with high mutagenic and/or carcinogenic potential. Although the human gut microbiota is known to affect the metabolism of dietary constituents, its impact on HAA metabolism and toxicity has been little studied. Here, the glycerol-dependent metabolism of seven foodborne HAAs (AαC, Trp-P-1, harman, norharman, PhIP, MeIQx, and MeIQ) by the human fecal microbiota is investigated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.2018011
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http://dx.doi.org/10.1002/mnfr.201801177DOI Listing
May 2019
5 Reads

Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases.

Glia 2019 07 28;67(7):1320-1332. Epub 2019 Feb 28.

CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Oligodendrocytes (OLs) are the myelinating glia of the central nervous system. Injury to OLs causes myelin loss. In demyelinating diseases, such as multiple sclerosis, the remyelination is hindered principally due to a failure of the oligodendrocyte precursor cells (OPCs) to differentiate into mature OLs. Read More

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http://dx.doi.org/10.1002/glia.23606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593996PMC
July 2019
4 Reads

Glial fibrillary acidic protein expression alters astrocytic chemokine release and protects mice from cuprizone-induced demyelination.

Glia 2019 07 23;67(7):1308-1319. Epub 2019 Feb 23.

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Enhanced glial fibrillary acidic protein (GFAP) expression occurs in most diseases of the central nervous system. Thus far, little is known about the effect that GFAP exerts on astrocyte cell signaling. In the present study, we observed that silencing GFAP expression in isolated astrocytes leads to enhanced CCL2 and CXCL10 release, whereas overexpression of GFAP in astrocytes results in a significantly reduced CXCL10 release in vitro. Read More

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http://dx.doi.org/10.1002/glia.23605DOI Listing
July 2019
1 Read

Molecular characterization of monocrotophos and chlorpyrifos tolerant bacterial strain for enhancing seed germination of vegetable crops.

Chemosphere 2019 May 14;223:636-650. Epub 2019 Feb 14.

Department of Soil Science and Agricultural Chemistry, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, 221005, UP, India.

The main aim of this study is to investigate the toxicity of organophosphate (OPs) insecticides monocrotophos (MCP) and chlorpyrifos (CLS) on plant growth promoting (PGP) properties and seed germination of brinjal, tomato and okra vegetables inoculated by Microbacterium hydrocarbonoxydans (BHUJP-P1), Stenotrophomonas rhizophila (BHUJP-P2), Bacillus licheniformis (BHUJP-P3) and Bacillus cereus (BHUJP-P4). Maximum increase in microbial growth (52.6% & 47. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.053DOI Listing
May 2019
9 Reads

Renalase attenuates mitochondrial fission in cisplatin-induced acute kidney injury via modulating sirtuin-3.

Life Sci 2019 Apr 21;222:78-87. Epub 2019 Feb 21.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. Electronic address:

Aims: Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and apoptosis. Previous studies showed renalase protected cultured human renal proximal tubular cell (HK-2) against cisplatin induced necrosis, and renalase-knockout mice subjected to cisplatin showed exacerbated kidney injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.042DOI Listing
April 2019
7 Reads

Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo.

Chem Commun (Camb) 2019 Feb;55(17):2477-2480

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo. Moreover, we have successfully used the high specificity of one of the probes to visualize MAO-A activity in zebrafish and tumor tissue for the first time. Read More

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http://dx.doi.org/10.1039/c8cc10084eDOI Listing
February 2019
18 Reads
6.834 Impact Factor

Adjuvant potential of selegiline in treating acute toxicity of aluminium phosphide in rats.

Basic Clin Pharmacol Toxicol 2019 Jul 21;125(1):62-74. Epub 2019 Feb 21.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Aluminium phosphide (AlP) is a highly toxic substance with a high mortality rate and no effective antidote. Once exposed to the moisture and acidic conditions of the stomach, AlP releases toxic phosphine (PH ) gas, which results in severe toxicity in poisoned subjects. Selegiline is a monoamine oxidase inhibitor with antioxidant and anti-apoptotic properties, which is mostly prescribed for the treatment of mood disorders and Parkinson's disease. Read More

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http://dx.doi.org/10.1111/bcpt.13207DOI Listing
July 2019
6 Reads

Hazardous ecotoxicological impact of two commonly used nitrofuran-derived antibacterial drugs: Furazolidone and nitrofurantoin.

Chemosphere 2019 May 26;222:381-390. Epub 2019 Jan 26.

Faculty of Mathematics and Natural Science, Jan Długosz University in Częstochowa, 13/15 Armii Krajowej Av., 42-200 Częstochowa, Poland. Electronic address:

This paper discusses the impact of two nitrofuran-derived drugs, namely furazolidone and nitrofurantoin on growth of oat and common radish as well as their impact on bacteria Allivibrio fischeri and crustaceans Heterocypris incongruens. Results indicated that both compounds were highly phytotoxic for radish (R. sativus) being simultaneously nearly not harmful for oat (A. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.144DOI Listing
May 2019
15 Reads
3.340 Impact Factor

Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies.

Drug Dev Ind Pharm 2019 May 12;45(5):839-851. Epub 2019 Feb 12.

a Department of Pharmaceutics , STES's Sinhgad Institute of Pharmacy (Affiliated to Savitribai Phule Pune University) , Narhe, Pune , India.

Background: Multiple sclerosis (MS) is one of the most severe autoimmune disorder of the central nervous system (CNS).

Objective: The present research work was aimed to formulate and investigate teriflunomide (TFM)-loaded intranasal (i.n. Read More

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https://www.tandfonline.com/doi/full/10.1080/03639045.2019.1
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http://dx.doi.org/10.1080/03639045.2019.1576724DOI Listing
May 2019
11 Reads

The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.

Glia 2019 05 22;67(5):967-984. Epub 2019 Jan 22.

Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), Okazaki, Aichi, Japan.

Protein tyrosine phosphatase receptor type Z (PTPRZ) maintains oligodendrocyte precursor cells (OPCs) in an undifferentiated state. The inhibition of PTPase by its ligand pleiotrophin (PTN) promotes OPC differentiation; however, the substrate molecules of PTPRZ involved in the differentiation have not yet been elucidated in detail. We herein demonstrated that the tyrosine phosphorylation of AFAP1L2, paxillin, ERBB4, GIT1, p190RhoGAP, and NYAP2 was enhanced in OPC-like OL1 cells by a treatment with PTN. Read More

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http://dx.doi.org/10.1002/glia.23583DOI Listing
May 2019
16 Reads

Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.

Clin Immunol 2019 04 17;201:35-47. Epub 2019 Jan 17.

Shanxi Medical University, Taiyuan030001, China; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan030024, China; Institute of Brain Science, Shanxi Datong University, Datong037009, China. Electronic address:

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system characterized by oligodendrocyte loss and progressive neurodegeneration. The cuprizone (CPZ)-induced demyelination is widely used to investigate the demyelination/remyelination. Here, we explored the therapeutic effects of Hydroxyfasudil (HF), an active metabolite of Fasudil, in CPZ model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183046
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http://dx.doi.org/10.1016/j.clim.2019.01.006DOI Listing
April 2019
27 Reads

The K -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration.

Glia 2019 05 9;67(5):870-883. Epub 2019 Jan 9.

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.

In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment in patients. After a demyelinating event, new myelin sheaths are formed by adult oligodendroglial progenitor cells; a process called remyelination. However, remyelination often fails in multiple sclerosis due to insufficient recruitment and differentiation of oligodendroglial precursor cells. Read More

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http://dx.doi.org/10.1002/glia.23577DOI Listing
May 2019
6 Reads

Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update.

Med Res Rev 2019 09 2;39(5):1603-1706. Epub 2019 Jan 2.

Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, India.

Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an indispensable approach of molecular and mechanistic diversity for the discovery of antineurodegenerative drugs. However, their usage has been hampered by nonselective and/or irreversible action which resulted in drawbacks like liver toxicity, cheese effect, and so forth. Hence, the search for selective MAO inhibitors (MAOIs) has become a substantial focus in current drug discovery. Read More

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http://dx.doi.org/10.1002/med.21561DOI Listing
September 2019
10 Reads

In vitro and in vivo evaluation of enzymatic and antioxidant activity, cytotoxicity and genotoxicity of curcumin-loaded solid dispersions.

Food Chem Toxicol 2019 Mar 25;125:29-37. Epub 2018 Dec 25.

Post-Graduation Program of Food Technology (PPGTA), Federal University of Technology - Paraná - UTFPR, Campus Campo Mourão, via Rosalina Maria dos Santos, 1233, CEP 87301-899, Caixa Postal: 271, Campo Mourão, PR, Brazil.

Curcumin, the main bioactive polyphenolic compound in Curcuma longa L. rhizomes has a wide range of bioactive properties. Curcumin presents low solubility in water and thus limited bioavailability, which decreases its applicability. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.037DOI Listing
March 2019
11 Reads

Aldehyde adducts inhibit 3,4-dihydroxyphenylacetaldehyde-induced α-synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy.

Eur J Pharmacol 2019 Feb 21;845:65-73. Epub 2018 Dec 21.

Departments of Neurology, School of Medicine, Saint Louis University Medical Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA; Departments of Medicine, School of Medicine, Saint Louis University Medical Center, 3635 Vista at Grand, Saint Louis, MO 63110, USA.

3,4-Dihydroxyphenylacetaldehyde (DOPAL), the monoamine oxidase (MAO) metabolite of dopamine, plays a role in pathogenesis of Parkinson disease, inducing α-synuclein aggregation. DOPAL generates discrete α-synuclein aggregates. Inhibiting this aggregation could provide therapy for slowing Parkinson disease progression. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.12.027DOI Listing
February 2019
6 Reads
2.532 Impact Factor

Arecoline attenuates memory impairment and demyelination in a cuprizone-induced mouse model of schizophrenia.

Neuroreport 2019 01;30(2):134-138

Xiamen Xian Yue Hospital, Xiamen, Fujian.

Cerebral demyelination is possibly one of the main pathological factors involved in the development of schizophrenia. Our previous studies have showed that Areca catechu nut extract could ameliorate cognitive decline by facilitating myelination processes in the frontal cortex in a cuprizone (CPZ)-induced mouse model of schizophrenia. The aim of the present study was to evaluate the effects of arecoline, one of the alkaloids in A. Read More

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http://Insights.ovid.com/crossref?an=00001756-201901020-0001
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http://dx.doi.org/10.1097/WNR.0000000000001172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326265PMC
January 2019
8 Reads
1.644 Impact Factor

Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and Signaling.

J Mol Neurosci 2019 Feb 13;67(2):265-275. Epub 2018 Dec 13.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Widespread inflammatory lesions within the central nervous system grey and white matter are major hallmarks of multiple sclerosis. The development of full-blown demyelinating multiple sclerosis lesions might be preceded by preactive lesions which are characterized by focal microglia activation in close spatial relation to apoptotic oligodendrocytes. In this study, we investigated the expression of signaling molecules of oligodendrocytes that might be involved in initial microglia activation during preactive lesion formation. Read More

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http://dx.doi.org/10.1007/s12031-018-1236-6DOI Listing
February 2019
4 Reads

Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.

ACS Chem Neurosci 2019 02 4;10(2):1008-1024. Epub 2019 Jan 4.

College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , 473061 , China.

A novel series of ferulic acid derivatives was designed and synthesized on the basis of the multi-target-directed ligands strategy for the treatment of Alzheimer's disease (AD). In vitro results revealed that all the target compounds were highly effective and selective butyrylcholinesterase (BuChE) inhibitors. In particular, compound TM-10 showed the best BuChE inhibitory activity, with IC = 8. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00530DOI Listing
February 2019
38 Reads

Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.

Eur J Med Chem 2019 Feb 26;163:307-319. Epub 2018 Nov 26.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

A series of resveratrol dimer derivatives against Alzheimer's disease (AD) was obtained by structural modification and transformation using resveratrol as substrate. Biological analysis revealed that these derivatives had moderate inhibitory activity against human monoamine oxidase B (hMAO-B). In particular, 3 and 7 showed the better inhibitory activity for hMAO-B (IC = 3. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.11.040DOI Listing
February 2019
7 Reads
3.447 Impact Factor