2,003 results match your criteria Toxicity Methamphetamine

Treatment of Malignant Hyperthermia During Interfacility Transport of a Patient With Methamphetamine Toxicity.

Air Med J 2022 May-Jun;41(3):320-322. Epub 2022 Feb 15.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.

Malignant hyperthermia (MH) is a rare disorder that leads to a hypermetabolic response; if unrecognized, it can quickly lead to serious morbidity and mortality. It is imperative that critical care transport providers are able to recognize and initiate treatment for MH. A 33-year-old man presented to the emergency department with seizures and altered mental status after ingesting methamphetamine. Read More

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February 2022

Identifying behaviours for survival and wellness among people who use methamphetamine with opioids in British Columbia: a qualitative study.

Harm Reduct J 2022 May 19;19(1):46. Epub 2022 May 19.

BC Centre for Disease Control, 655 W 12th Ave, Vancouver, BC, V5Z 4R4, Canada.

Background: British Columbia (BC) has been in a state of public health emergency since 2016, due to the unprecedented numbers of fatal and non-fatal drug toxicity (i.e. overdose) events. Read More

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MicroRNAs in Methamphetamine-Induced Neurotoxicity and Addiction.

Front Pharmacol 2022 14;13:875666. Epub 2022 Apr 14.

Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, China.

Methamphetamine (METH) abuse remains a significant public health concern globally owing to its strong addictive properties. Prolonged abuse of the drug causes irreversible damage to the central nervous system. To date, no efficient pharmacological interventions are available, primarily due to the unclear mechanisms underlying METH action in the brain. Read More

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Factors associated with perceived decline in the quality of drugs during the COVID-19 pandemic: Evidence from community-recruited cohorts of people who use drugs in Vancouver, Canada.

Drug Alcohol Depend 2022 Apr 25;236:109471. Epub 2022 Apr 25.

British Columbia Centre on Substance Use, 400-1045 Howe St., Vancouver, BC V6Z 2A9, Canada; School of Public Policy, Simon Fraser University, 515 West Hastings St., Vancouver, BC V6B 5K3, Canada. Electronic address:

Objectives: Driven by an increasingly toxic drug supply, drug toxicity deaths in the United States and Canada have risen to unprecedented levels during the COVID-19 pandemic. This study aimed to characterize the prevalence of and the factors associated with a perceived decline in the quality of drugs during the COVID-19 pandemic among community-recruited cohorts of PWUD in Vancouver, Canada.

Methods: Data collection took place between July and November 2020. Read More

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Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress.

Oxid Med Cell Longev 2022 18;2022:4445734. Epub 2022 Apr 18.

School of Health and Physical Education, Jianghan University, Wuhan 430056, China.

Methamphetamine can cause oxidative stress-centered lipid peroxidation, endoplasmic reticulum stress, mitochondrial dysfunction, excitatory neurotoxicity, and neuroinflammation and ultimately lead to nerve cell apoptosis, abnormal glial cell activation, and dysfunction of blood-brain barrier. Protecting nerve cells from oxidative destroy is a hopeful strategy for treating METH use disorder. Nrf2 is a major transcriptional regulator that activates the antioxidant, anti-inflammatory, and cell-protective gene expression through endogenous pathways that maintains cell REDOX homeostasis and is conducive to the survival of neurons. Read More

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Role of the cannabinoid CB1 receptor in methamphetamine-induced social and recognition memory impairment.

Neurosci Lett 2022 05 14;779:136634. Epub 2022 Apr 14.

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Methamphetamine (METH) has been reported to induce social and recognition memory impairment. Evidence suggests that the cannabinoid system has an important modulatory role in cognitive processing and social interaction. Nonetheless, no previous study has investigated the probable role of the cannabinoids system on METH-induced deficits of novel object recognition (NOR) memory and social interaction. Read More

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Terminalia chebula extracts ameliorate methamphetamine-induced memory deficits via activating the ERK and Nrf2 pathway.

Brain Res Bull 2022 Jun 8;184:76-87. Epub 2022 Apr 8.

Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China. Electronic address:

As a psychoactive substance abused worldwide, methamphetamine (METH) abuse leads to multiple neurodegenerative symptoms including memory deficits. Terminalia chebula retzius extracts (TREs) isolated by our lab have great antioxidant activity and its effect on METH-induced memory deficits has not been investigated yet. The present study was designed to investigate the protective effect of TREs on METH induced cell apoptosis in vitro and memory deficits in vivo. Read More

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Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice.

Toxicol Appl Pharmacol 2022 May 4;443:116011. Epub 2022 Apr 4.

Department of Toxicology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No. 1838 North Guangzhou Road, 510515 Guangzhou, China. Electronic address:

Methamphetamine (METH) is a psychostimulant abused worldwide. Its abuse induces intestinal toxicity. Moreover, the gut microbiota is altered by drugs, which induces intestinal injury. Read More

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Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.

Oxid Med Cell Longev 2022 28;2022:8400876. Epub 2022 Mar 28.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.

Chronic and long-term methamphetamine (METH) abuse is bound to cause damages to multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS), a type of flavonoid and one of the main active ingredients of the traditional Chinese medicine , exhibits a variety of biological and pharmacological properties such as anti-inflammatory, antioxidant, and anticancer activities. However, whether ICS could protect against METH-induced neurotoxicity remains unknown. Read More

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Neuroligin-1 plays an important role in methamphetamine-induced hippocampal synaptic plasticity.

Toxicol Lett 2022 May 22;361:1-9. Epub 2022 Mar 22.

School of Forensic Medicine, Wannan Medical College, NO. 22 West Wen Chang Rd, Wuhu 241000, People's Republic of China. Electronic address:

The neurotoxic effects of methamphetamine (METH) include not only neuronal apoptosis and autophagy, but also lead to substance use disorder and have become increasingly prominent. Studies suggest that synaptic plasticity may be the structural basis of METH-induced neurological impairment. Neuroligins are postsynaptic adhesion molecules involved in the regulation of synaptic organization and function. Read More

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Research Progress on the Omics of Methamphetamine Toxic Damage and Addiction.

Fa Yi Xue Za Zhi 2021 Dec;37(6):776-787

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.

The mechanism of methamphetamine toxicity and addiction is the key research direction of forensic toxicology, and the development of omics technology provides a new platform for further study of this direction. METH toxic damage and addiction are reflected differently in genes, ribonucleic acid (RNA) transcription, protein and metabolism. This article summarizes the achievements and shortcomings of multi-omics technologies such as genome, transcriptome, metabolome and proteome in the study of METH damage and addiction, and discusses the strategies and advantages of multi-omics combined analysis in the study of METH toxic damage and addiction mechanism, in order to provide more useful reference information for forensic toxicology of METH. Read More

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December 2021

Current Situation of Methamphetamine Abuse and Related Research Progress.

Fa Yi Xue Za Zhi 2021 Dec;37(6):763-775

School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.

Drug problem is a major social and public security problem in the world. Drug abuse poses a great threat to economic development, social stability and public health. In recent years, synthetic drugs represented by methamphetamine have surpassed traditional drugs such as morphine, heroin, ketamine and become one of the most abused drugs in the world. Read More

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December 2021

Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway.

Psychopharmacology (Berl) 2022 Mar 21;239(3):951-964. Epub 2022 Feb 21.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.

Rationale: Clinical studies have revealed that methamphetamine abuse increases risk for developing Parkinson's diseases. It is thus important to elucidate the mechanisms by which methamphetamine damages dopaminergic neurons.

Objectives: The present study was designed to elucidate the role of the dopamine D1 receptor in methamphetamine-mediated dopaminergic neuronal damage and its underlying mechanisms. Read More

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Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.

J Pharmacol Exp Ther 2022 05 13;381(2):129-136. Epub 2022 Feb 13.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota (C.A.B., M.M.W., M.P.); Department of Veterinary Population Medicine, University of Minnesota, Minneapolis, Minnesota (M.M.W.); Reno School of Medicine, University of Nevada, Reno, Nevada (S.G.P., J.A.-U., D.A.); University of Minnesota Center for Immunology, Minneapolis, Minnesota (M.P.); and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington (M.P.).

The incidence of fatal drug overdoses in the United States is an alarming public health threat that has been exacerbated by the COVID-19 pandemic, resulting in over 100,000 deaths between April 2020 and April 2021. A significant portion of this is attributable to widespread access to fentanyl and other synthetic opioids, alone or in combination with heroin or psychostimulants, such as cocaine or methamphetamine. Monoclonal antibodies (mAb) offer prophylactic and therapeutic interventions against opioid overdose by binding opioids in serum, reducing distribution of drug to the brain and other organs. Read More

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Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats.

Eur J Drug Metab Pharmacokinet 2022 May 8;47(3):319-330. Epub 2022 Feb 8.

Department of Pharmaceutical Science, Marshall University School of Pharmacy, Kopp Hall 353, 1 John Marshall Drive, Huntington, WV, 25755, USA.

Background And Objectives: Whole-body radiation exposure has been shown to alter the pharmacokinetics of certain drugs in both animal models and humans, but little is known about the effect of radiation on psychoactive medications. These drugs may have altered pharmacokinetics when administered during or after space travel or therapeutic or accidental radiation exposure, resulting in reduced efficacy or increased toxicity.

Methods: Methamphetamine was used to determine the effects of acutely administered 1, 3, and 6 Gy radiation on drug pharmacokinetics and pharmacodynamics. Read More

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Remembering Molly: Immediate and delayed false memory formation after acute MDMA exposure.

Eur Neuropsychopharmacol 2022 Apr 3;57:59-68. Epub 2022 Feb 3.

Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands. Electronic address:

The entactogen 3,4-Methylenedioxymethamphetamine (MDMA) is increasingly being recognized for its therapeutic potential but is also widespread in nightlife settings where it may co-occur with crime. Since previous research detected impaired verbal memory during acute MDMA intoxication, understanding the drug's ramifications in an applied legal context becomes crucial. We conducted a double-blind, placebo-controlled trial to examine acute and delayed effects of MDMA (75 mg) on false memory in 60 healthy volunteers with a history of MDMA use, using three well-established false memory methods: a basic, associative word list (Deese/Roediger-McDermott (DRM)) paradigm and two applied misinformation tasks using a virtual reality crime. Read More

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Emergency department visits and trends related to cocaine, psychostimulants, and opioids in the United States, 2008-2018.

BMC Emerg Med 2022 02 4;22(1):19. Epub 2022 Feb 4.

Department of Medicine, Division of HIV, Infectious Diseases and Global Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Background: Drug-related emergency department (ED) visits are escalating, especially for stimulant use (i.e., cocaine and psychostimulants such as methamphetamine). Read More

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February 2022

The diagnostic utility of procalcitonin is limited in the setting of methamphetamine toxicity.

Am J Emerg Med 2022 Apr 26;54:36-40. Epub 2022 Jan 26.

UC San Diego, Pulmonary, Critical Care, and Sleep Medicine, United States of America; UC San Diego, Emergency Medicine, United States of America. Electronic address:

Procalcitonin (PCT) is a biomarker with greater specificity for bacterial infection than other current laboratory markers. However, PCT can also be elevated in the setting of several noninfectious conditions. A recent case report describes a patient with elevated PCT in the context of acute methamphetamine intoxication, but without evidence of infection. Read More

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Does paternal methamphetamine exposure affect the behavior of rat offspring during development and in adulthood?

Physiol Res 2021 12;70(S3):S419-S430

Department of Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Methamphetamine (MA) is one of the most abused psychostimulants in the Czech Republic and worldwide. Previous studies have demonstrated the adverse effects of maternal drug abuse. However, the father's contribution as a parent and donor of the half genetic information is unclear. Read More

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December 2021

Methamphetamine, neurotransmitters and neurodevelopment.

Physiol Res 2021 12;70(S3):S301-S315

Department of Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Methamphetamine (MA), as massively abused psychoactive stimulant, has been associated with many neurological diseases. It has various potent and neurotoxic properties. There are many mechanisms of action that contribute to its neurotoxic and degenerative effects, including excessive neurotransmitter (NEU) release, blockage of NEU uptake transporters, degeneration of NEU receptors, process of oxidative stress etc. Read More

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December 2021

The relationship between serum brain-derived neurotrophic level and neurocognitive functions in chronic methamphetamine users.

Neurosci Lett 2022 02 24;772:136478. Epub 2022 Jan 24.

Research Center for Addiction and Risky Behaviors, Iran University of Medical Sciences, Tehran, Iran; Department of Addiction, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Methamphetamine (METH) is a highly addictive psychostimulant with serious neurotoxic effects. Given evidence indicating that brain-derived neurotrophic factor (BDNF) is associated with addictive behaviors, this study aimed to investigate the serum level of BDNF and cognitive functions in chronic METH users and healthy participants. Thirty-seven chronic METH users and 37 healthy participants were recruited in this study. Read More

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February 2022

in Vitro Effect of Methamphetamine on Proliferation, Differentiation and Apoptosis of Adipose Tissue Stem Cells.

J Pharm Pharm Sci 2022 ;25:69-76

Department of Laboratory Medicine and Pathology, University of Alberta and 6Innovation and Portfolio Management, Canadian Blood Services, Edmonton, AB, Canada.

Purpose: Among abused substances, methamphetamine is a psychostimulant drug widely used recreationally with public health importance. This study investigated the effect of methamphetamine on proliferation, differentiation, and apoptosis of human adipose tissue stem cells (AdSCs).

Methods: AdSCs were isolated from human abdominal adipose tissue and were characterized for mesenchymal properties and growth kinetics. Read More

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Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity.

Int J Mol Sci 2021 Dec 29;23(1). Epub 2021 Dec 29.

Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA.

Methamphetamine (METH) is a highly abused psychostimulant that is neurotoxic to dopaminergic (DAergic) nerve terminals in the striatum and increases the risk of developing Parkinson's disease (PD). In vivo, METH-mediated DA release, followed by DA-mediated oxidative stress and mitochondrial dysfunction in pre- and postsynaptic neurons, mediates METH neurotoxicity. METH-triggered oxidative stress damages parkin, a neuroprotective protein involved in PD etiology via its involvement in the maintenance of mitochondria. Read More

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December 2021

Effects of methamphetamine-induced neurotoxicity on striatal long-term potentiation.

Psychopharmacology (Berl) 2022 Jan 5;239(1):93-104. Epub 2022 Jan 5.

Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT, USA.

Rationale: Methamphetamine (METH) exposure is associated with damage to central monoamine systems, particularly dopamine signaling. Rodent models of such damage have revealed a decrease in the amplitude of phasic dopamine signals and significant striatal dysfunction, including changes in the molecular, system, and behavioral functions of the striatum. Dopamine signaling through D1 receptors promotes corticostriatal long-term potentiation (LTP), a critical substrate of these striatal functions. Read More

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January 2022

The Crosstalk Between Neurons and Glia in Methamphetamine-Induced Neuroinflammation.

Neurochem Res 2022 Apr 4;47(4):872-884. Epub 2022 Jan 4.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, China.

Methamphetamine (METH), an illicit psycho-stimulant, is widely known as an addictive drug that may cause neurotoxic effects. Previous researches on METH abuse have mainly focused on neurotransmitters, such as dopamine and glutamate. However, there is growing evidence that neuroinflammation also plays an important role in the etiology and pathophysiology of brain dysfunction induced by METH abuse. Read More

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Toxicological Analysis of Cases of Mixed Poisonings with Synthetic Cathinones and other Drugs of Abuse.

J Anal Toxicol 2021 Nov 24. Epub 2021 Nov 24.

Department of Cytophysiology, Chair of Histology and Embryology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Some of the most commonly used new psychoactive substances (NPSs) are synthetic cathinones (SCs). The literature increasingly indicates that SCs have a significant addictive potential and pose a high risk to human health and life. The vast majority of SC users take a number of substances simultaneously. Read More

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November 2021

Peri-adolescent exposure to (meth)amphetamine in animal models.

Int Rev Neurobiol 2022 20;161:1-51. Epub 2021 Aug 20.

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.

Experimentation with psychoactive drugs is often initiated in the peri-adolescent period, but knowledge of differences in the outcomes of peri-adolescent- vs adult-initiated exposure is incomplete. We consider the existing animal research in this area for (meth)amphetamines. Established for a number of phenotypes, is lower sensitivity of peri-adolescents than adults to acute effects of (meth)amphetamines, including neurotoxic effects of binge-level exposure. Read More

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January 2022

Comparative Neuropharmacology and Pharmacokinetics of Methamphetamine and Its Thiophene Analog Methiopropamine in Rodents.

Int J Mol Sci 2021 Nov 5;22(21). Epub 2021 Nov 5.

Department of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.

Methiopropamine is a novel psychoactive substance (NPS) that is associated with several cases of clinical toxicity, yet little information is available regarding its neuropharmacological properties. Here, we employed in vitro and in vivo methods to compare the pharmacokinetics and neurobiological effects of methiopropamine and its structural analog methamphetamine. Methiopropamine was rapidly distributed to the blood and brain after injection in C57BL/6 mice, with a pharmacokinetic profile similar to that of methamphetamine. Read More

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November 2021

Green coffee extract attenuates Parkinson's-related behaviors in animal models.

An Acad Bras Cienc 2021 1;93(suppl 4):e20210481. Epub 2021 Nov 1.

Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, Rua Arcturus, 03, 09606-070 São Bernardo do Campo, SP, Brazil.

Epidemiological studies have shown an inverse association between coffee consumption and the development of Parkinson's disease (PD). The effects of the oral treatment with green (non-roasted) coffee extracts (CE, 100 or 400 mg/kg) and caffeine (31.2 mg/kg) were evaluated on catalepsy induced by haloperidol in mice, and unilateral 6-OHDA lesion of medial forebrain bundle (MFB) or striatum in rats. Read More

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November 2021

Prescribed aggression of fishes: Pharmaceuticals modify aggression in environmentally relevant concentrations.

Ecotoxicol Environ Saf 2021 Dec 27;227:112944. Epub 2021 Oct 27.

University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 398 25 Vodňany, Czech Republic.

Traces of psychoactive substances have been found in freshwaters globally. Fish are chronically exposed to pollution at low concentrations. The changes of aggressive behaviour of chub (Squalius cephalus) were determined under the exposure to four psychoactive compounds (sertraline, citalopram, tramadol, methamphetamine) at environmentally relevant concentrations of 1 μg/L for 42 days. Read More

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December 2021