1,808 results match your criteria Toxicity Methamphetamine


Drinking to death: Hyponatraemia induced by synthetic phenethylamines.

Drug Alcohol Depend 2020 Apr 29;212:108045. Epub 2020 Apr 29.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal. Electronic address:

Synthetic phenethylamines are widely abused drugs, comprising new psychoactive substances such as synthetic cathinones, but also well-known amphetamines such as methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Cathinones and amphetamines share many toxicodynamic mechanisms. One of their potentially life-threatening consequences, particularly of MDMA, is serotonin-mediated hyponatraemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2020.108045DOI Listing

Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine.

Int J Mol Sci 2020 May 2;21(9). Epub 2020 May 2.

D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya line 3, 199034 St. Petersburg, Russia.

Convincing evidence accumulated over the last decades demonstrates the crucial role of epigenetic modifications for mammalian genome regulation and its flexibility. DNA methylation and demethylation is a key mechanism of genome programming and reprogramming. During ontogenesis, the DNA methylome undergoes both programmed changes and those induced by environmental and endogenous factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21093223DOI Listing

TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.

Oxid Med Cell Longev 2020 13;2020:8787156. Epub 2020 Apr 13.

Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.

Methamphetamine (METH) leads to nervous system toxicity. Long-term exposure to METH results in damage to dopamine neurons in the ventral tegmental area (VTA), and depression-like behavior is a clinical symptom of this toxicity. The current study was designed to investigate whether the antioxidant tertiary butylhydroquinone (TBHQ) can alleviate neurotoxicity through both antioxidative stress and antiapoptotic signaling pathways in the VTA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8787156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174937PMC

The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin.

J Neuroimmunol 2020 Jul 4;344:577232. Epub 2020 Apr 4.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand. Electronic address:

Neuron-Glial2 (NG2) expressing cells are described as the oligodendrocyte precursor cells in the brain. This study aimed to investigate the possible involvement of NG2 cells under the methamphetamine (METH)-induced neurotoxicity and neuroprotective capacity of melatonin. The results showed that the levels of NG2 in rat brain gradually increase from postnatal day 0 to postnatal day 8 and then the lower levels of NG2 are shown in adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneuroim.2020.577232DOI Listing

Increasing Methamphetamine Detection in Cases of Early Childhood Fatalities.

J Forensic Sci 2020 Mar 23. Epub 2020 Mar 23.

Forensic Science SA, GPO Box 2790, Adelaide, 5001, South Australia, Australia.

Age and organ maturity can influence drug toxicity in children; however, most clinical data and literature are based on drug concentrations in adults. Therefore, the interpretation of drugs detected in children is often difficult or not possible. Retrospective reviewing of pathology and toxicology information from postmortem cases may assist in future interpretations or identify drug trends. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1556-4029.14321DOI Listing

High ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone.

Pharmacol Biochem Behav 2020 May 19;192:172912. Epub 2020 Mar 19.

Department of Pharmacology & Experimental Therapeutics, College of Pharmacology and Pharmacological Science, University of Toledo, OH, USA. Electronic address:

Rationale: Methylenedioxymethamphetamine (MDMA) and methcathinone (MCAT) are abused psychostimulant drugs that produce adverse effects in human users that include hepatotoxicity and death. Recent work has suggested a connection between hepatotoxicity, elevations in plasma ammonia, and brain glutamate function for methamphetamine (METH)-induced neurotoxicity.

Objectives: These experiments investigated the effect of ambient temperature on the toxicity and lethality produced by MDMA and MCAT in mice, and whether these effects might involve similar mechanisms to those described for METH neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbb.2020.172912DOI Listing

Methamphetamine exposure modulated oxidative status and altered the reproductive output in Daphnia magna.

Sci Total Environ 2020 Jun 10;721:137728. Epub 2020 Mar 10.

Department of Environmental Science and Policy, University of Milan, via Celoria 26, I-20133 Milan, Italy.

Methamphetamine (METH) is a central nervous system stimulant drug whose use has increased in the last few years worldwide. After the ingestion of even a single dose, METH is excreted by the organism and enters the aquatic ecosystems, whereby concentrations up to hundreds of ng/L were measured in both sewage and surface waters. Although the environmental concentrations are currently quite low, the high biological activity of METH might cause adverse effects towards non-target organisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.137728DOI Listing

Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway.

Int J Mol Sci 2020 Feb 27;21(5). Epub 2020 Feb 27.

College of Pharmacy, Keimyung University, Daegu 42601, Korea.

Methamphetamine (METH) is an addictive psychostimulant showing neurotoxicity through neuronal apoptosis and the neuro-inflammatory pathway. Lupenone, a lupane triterpenoid, is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. However, whether lupenone plays a protective role against apoptosis induced by METH in SH-SY5y neuroblastoma cells remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21051617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084488PMC
February 2020

Low concentrations of methamphetamine can suppress inflammation in trophoblast JEG-3 cell line induced by nicotine.

Bratisl Lek Listy 2020 ;121(3):225-229

Aim: Nicotine at high concentrations induces apoptosis in trophoblastic cells through induction of cell cytotoxicity and Reactive Oxygen Species (ROS). Methamphetamine in low dose has pharmaceutical properties. It seems that this components in low dose can protect the trophoblastic cells from nicotine-induced cell death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4149/BLL_2020_034DOI Listing

Environmental behavior of methamphetamine and ketamine in aquatic ecosystem: Degradation, bioaccumulation, distribution, and associated shift in toxicity and bacterial community.

Water Res 2020 May 4;174:115585. Epub 2020 Feb 4.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, PR China. Electronic address:

Ketamine (KET) and methamphetamine (METH) have been recognized as emerging contaminants in aquatic ecosystems. This paper aimed to investigate the environmental behaviour, including the degradation, distribution, and bioaccumulation, of METH, KET, and their main metabolites (amphetamine (AMP) and norketamine (NorKET)). The changes in acute toxicity in the aqueous phase and in the bacterial community in sediment were determined to assess the associated eco-risk of the drug exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.115585DOI Listing

Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication.

Acta Pharm Sin B 2020 Feb 6;10(2):239-248. Epub 2019 Nov 6.

Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.

Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.apsb.2019.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016289PMC
February 2020

Epigallocatechin Gallate Mitigates the Methamphetamine-Induced Striatal Dopamine Terminal Toxicity by Preventing Oxidative Stress in the Mouse Brain.

Neurotox Res 2020 Apr 21;37(4):883-892. Epub 2020 Feb 21.

Department of Biological Sciences, Hunter College, 695 Park Avenue, New York, NY, 10065, USA.

Methamphetamine (METH) is a popular psychostimulant due to its long-lasting effects and inexpensive production. METH intoxication is known to increase oxidative stress leading to neuronal damage. Thus, preventing the METH-induced oxidative stress can potentially mitigate neuronal damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-020-00177-1DOI Listing

Characteristics of analytically confirmed illicit substance-using patients in the Emergency Department.

J Formos Med Assoc 2020 Feb 6. Epub 2020 Feb 6.

Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan; Forensic and Clinical Toxicology Center, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: Although illicit substance use-induced toxicity or complication is a frequent cause of visit to the emergency department (ED), there are limited data on cases confirmed by liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis. This study aimed to describe clinical presentations of patients who visited the ED because of acute illicit substance-related complications.

Methods: We performed a retrospective study between May 2017 and August 2018 on patients presenting to the ED with positive urine illicit substance analysis by LC-MS/MS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfma.2020.01.005DOI Listing
February 2020

Methamphetamine causes acute toxicity in the retina of Balb/c mice.

Cutan Ocul Toxicol 2020 Jun 7;39(2):83-88. Epub 2020 Feb 7.

Department of Neurology, The First People's Hospital of Yibin, Yibin, People's Republic of China.

As a powerful psychostimulant with high potential for abuse, methamphetamine (Meth) could cause neurological diseases. METH-induced ophthalmic complications are present, but its underlying mechanism has not been completely elucidated, specifically on the retina. This study was to investigate effects of Meth treatment on the retina. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2020.1722153DOI Listing

How microplastics affect chiral illicit drug methamphetamine in aquatic food chain? From green alga (Chlorella pyrenoidosa) to freshwater snail (Cipangopaludian cathayensis).

Environ Int 2020 Mar 18;136:105480. Epub 2020 Jan 18.

Beijing Key Laboratory of Emerging Organic Contaminants Control, State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.

The biological impacts of microplastics on many organisms have been well documented. However, the combined effects of microplastics and chiral chemicals on the aquatic food chain are less clear. In the present study, the enantioselective environmental behaviors of methamphetamine co-exposed with microplastics through an aquatic food chain (from Chlorella pyrenoidosa to Cipangopaludian cathayensis) have been investigated in a laboratory environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2020.105480DOI Listing
March 2020
5.559 Impact Factor

Methamphetamine-related cardiovascular diseases.

ESC Heart Fail 2020 Apr 17;7(2):407-414. Epub 2020 Jan 17.

Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany.

Aims: Abuse of crystal methamphetamine (MA) poses a growing problem for health services worldwide. This review summarizes the current literature on the effects of MA on the cardiovascular system.

Methods And Results: This article is a presentation of a case report and review of the current literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ehf2.12572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160483PMC

6-Formyl-5-isopropyl-3-hydroxymethyl- 7-methyl-1H-indene mitigates methamphetamine-induced photoreceptor cell toxicity through inhibiting oxidative stress.

Hum Exp Toxicol 2020 May 13;39(5):712-720. Epub 2020 Jan 13.

Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China.

As an extremely addictive psychostimulant drug and an illicit dopaminergic neurotoxin, methamphetamine (METH) conducts to enhance satisfaction, feelings of alertness through influencing monoamine neurotransmitter systems. Long-lasting exposure to METH causes psychosis and increases the risk of neurodegeneration. 6-Formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene (FIHMI) is a novel compound with potent antioxidant properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0960327119896617DOI Listing

Substance abuse effects on urinary tract: methamphetamine and ketamine.

Hong Kong Med J 2019 12 4;25(6):438-443. Epub 2019 Dec 4.

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.

Introduction: Ketamine is known to cause urinary tract dysfunction. Recently, methamphetamine (MA) abuse has become a growing problem in Asia. We investigated the symptomatology and voiding function in patients who abused MA and ketamine and compared their urinary tract toxicity profiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12809/hkmj198154DOI Listing
December 2019

The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitro.

Toxicol Lett 2020 Feb 26;319:213-224. Epub 2019 Nov 26.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

The upregulated α-synuclein (α-syn) and Tau co-occur in methamphetamine (METH) abusers' brains. Here, we designed experiments mainly to investigate whether α-syn and Tau interact in METH exposure. We detected the expression of α-syn, total Tau, and phosphorylation of Tau at Serine 396 (pSer396 Tau) under in vitro and in vivo conditions after METH exposure to determine the co-occurrence of α-syn and Tau. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.11.028DOI Listing
February 2020

Household Contamination with Methamphetamine: Knowledge and Uncertainties.

Int J Environ Res Public Health 2019 11 23;16(23). Epub 2019 Nov 23.

College of Science and Engineering, Flinders University, Adelaide, SA 5001, Australia.

Contamination of residential homes with methamphetamine is an emerging issue of significant concern to public health. Cooking or smoking methamphetamine in a residential property contaminates the house, furnishings and personal possessions within it, with subsequent exposure through ingestion, dermal absorption and/or inhalation causing adverse health effects. Current guidelines identifying levels of methamphetamine contamination that require remediation vary between countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16234676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926576PMC
November 2019

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.

Neural Regen Res 2020 May;15(5):802-816

Department of Biomedical Sciences; National Institute of Neuroscience (INN), University of Cagliari, Cagliari, Italy.

Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the rise among young and adult people. The present review summarizes recent findings on the peripheral and central toxicity elicited by "old" and "new" synthetic psychoactive substances in humans and experimental animals, focusing on amphetamine derivatives, hallucinogen and dissociative drugs and synthetic cannabinoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.268895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990793PMC

Methamphetamine use association with pulmonary diseases: a retrospective investigation of hospital discharges in California from 2005 to 2011.

ERJ Open Res 2019 Oct 15;5(4). Epub 2019 Oct 15.

Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA.

Background: Methamphetamine can have acute and long-term adverse health consequences. Our objective was to determine whether methamphetamine use is associated with more hospitalisation codes for asthma exacerbation, chronic obstructive pulmonary disease (COPD) exacerbation, pneumonia and acute respiratory failure (ARF).

Methods: The Health Care Utilization Project (HCUP) database includes retrospective inpatient discharge abstracts from 2005 through 2011 from the California state inpatient databases (SIDs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/23120541.00017-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791966PMC
October 2019
2 Reads

Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.

Toxicol In Vitro 2020 Feb 16;62:104668. Epub 2019 Oct 16.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, PR China. Electronic address:

Methamphetamine (MA) has a high uptake in lung, but the precise mechanism of MA-induced lung toxicity remains unclear. The aim of this study is to investigate the role of MA abuse in remodeling of pulmonary arteries and to explore the possible correlation of the association of the remodeling with the redox imbalance in pulmonary arterial smooth muscle cells (PASMCs). Wistar rats were randomly divided into control group and MA group for the experimental study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2019.104668DOI Listing
February 2020
1 Read

Poor outcomes in methamphetamine-associated cardiomyopathy-a growing health issue in New Zealand.

N Z Med J 2019 09 20;132(1502):55-66. Epub 2019 Sep 20.

Department of Cardiology, Middlemore Hospital, Auckland.

Background: Methamphetamine-associated cardiomyopathy (MAC) is increasingly recognised as a serious consequence of chronic metamphetamine use. Evidence to guide management and prognostication of patients with MAC compared to other cardiomyopathies remain limited.

Methods: Clinical characteristics, in-hospital and post-discharge outcomes were collected in consecutive MAC patients at Middlemore Hospital from 2006-2018, and compared with a 1:1 age-range matched cohort with non-ischaemic cardiomyopathy (NCM). Read More

View Article

Download full-text PDF

Source
September 2019
2 Reads

Current Understanding of Methamphetamine-Associated Metabolic Changes Revealed by the Metabolomics Approach.

Metabolites 2019 Sep 20;9(10). Epub 2019 Sep 20.

College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea.

Metabolomics is a powerful tool used in the description of metabolic system perturbations caused by diseases or abnormal conditions, and it usually involves qualitative and/or quantitative metabolome determination, accompanied by bioinformatics assessment. Methamphetamine is a psychostimulant with serious abuse potential and due to the absence of effective pharmacotherapy and a high recurrence potential, methamphetamine addiction is a grave issue. Moreover, its addiction mechanisms remain unclear, probably due to the lack of experimental models that reflect personal genetic variances and environmental factors determining drug addiction occurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/metabo9100195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835349PMC
September 2019
1 Read

[The Cognitive, Language and Motor Development of Prenatal Methamphetamine- and Opioid-exposed Children].

Klin Padiatr 2019 Sep 10;231(5):262-268. Epub 2019 Sep 10.

Department of Neuropediatrics, Universitätsklinikum Leipzig, Leipzig.

Objective: The consumption of illegal substances during pregnancy is an increasing social and medical issue. Main substances of prenatal drug exposure are beside tehtrahydrocannabinol (THC), opioids and methamphetamine. The effect of these substances on the long-term development of children remains uncertain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0981-6322DOI Listing
September 2019
6 Reads

Aquatic Phytotoxicity to Lemna minor of Three Commonly Used Drugs of Addiction in Australia.

Bull Environ Contam Toxicol 2019 Nov 3;103(5):710-716. Epub 2019 Sep 3.

Natural and Built Environments Research Centre, School of Natural and Built Environments, University of South Australia, Mawson Lakes, SA, 5095, Australia.

The manufacturing and consumption of drugs of addiction has increased globally and their widespread occurrence in the environment is an emerging concern. This study evaluated the phytotoxicity of three compounds: methamphetamine, codeine and morphine; commonly reported in Australian urban water, to the aquatic plant Lemna minor under controlled conditions. L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00128-019-02708-9DOI Listing
November 2019
1.255 Impact Factor

Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells.

Neurotoxicology 2019 12 29;75:158-173. Epub 2019 Aug 29.

UCIBIO, REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Portugal; FP-ENAS (Unidade de Investigação UFP em Energia, Ambiente e Saúde), CEBIMED (Centro de Estudos em Biomedicina), Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Portugal. Electronic address:

Synthetic cathinones also known as β-keto amphetamines are a new group of recreational designer drugs. We aimed to evaluate the cytotoxic potential of thirteen cathinones lacking the methylenedioxy ring and establish a putative structure-toxicity profile using differentiated SH-SY5Y cells, as well as to compare their toxicity to that of amphetamine (AMPH) and methamphetamine (METH). Cytotoxicity assays [mitochondrial 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) reduction and lysosomal neutral red (NR) uptake] performed after a 24-h or a 48-h exposure revealed for all tested drugs a concentration-dependent toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2019.08.009DOI Listing
December 2019
9 Reads

A complicated case of bowel obstruction with sepsis and methamphetamine toxicity in a child with pica.

Forensic Sci Med Pathol 2019 Dec 23;15(4):598-602. Epub 2019 Aug 23.

Western Michigan University Homer Stryker M.D. School of Medicine, 276 Portage Street #200, Kalamazoo, MI, 49007, USA.

In this report, a pediatric case of bowel obstruction with sepsis complicated by methamphetamine toxicity is described. The decedent, an eleven-year-old female with a clinical history of pica, was found unresponsive in her home and pronounced dead following unsuccessful resuscitative efforts. Radiologic imaging showed multiple radio-opaque foreign objects in the stomach and bowel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12024-019-00143-0DOI Listing
December 2019
5 Reads

Methamphetamine-associated psychosis: Clinical presentation, biological basis, and treatment options.

Hum Psychopharmacol 2019 09 22;34(5):e2710. Epub 2019 Aug 22.

UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, Massachusetts.

Introduction: Methamphetamine associated psychosis (MAP) represents a mental disorder induced by chronic methamphetamine use in a subset of users. The prevalence of the disorder has increased in several countries in Europe and Asia where methamphetamine use has increased. MAP remains difficult to distinguish from primary psychiatric disorders, especially schizophrenia, creating complications in prescribing treatment plans to patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hup.2710DOI Listing
September 2019
5 Reads

Methamphetamine Use and Cardiovascular Disease.

Arterioscler Thromb Vasc Biol 2019 09 21;39(9):1739-1746. Epub 2019 Aug 21.

From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.

While the opioid epidemic has garnered significant attention, the use of methamphetamines is growing worldwide independent of wealth or region. Following overdose and accidents, the leading cause of death in methamphetamine users is cardiovascular disease, because of significant effects of methamphetamine on vasoconstriction, pulmonary hypertension, atherosclerotic plaque formation, cardiac arrhythmias, and cardiomyopathy. In this review, we examine the current literature on methamphetamine-induced changes in cardiovascular health, discuss the potential mechanisms regulating these varied effects, and highlight our deficiencies in understanding how to treat methamphetamine-associated cardiovascular dysfunction. Read More

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312461
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.119.312461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709697PMC
September 2019
2 Reads

4-Fluoromethylphenidate: Fatal Intoxication Involving a Previously Unreported Novel Psychoactive Substance in the USA.

J Anal Toxicol 2019 Sep;43(8):666-672

Miami-Dade Medical Examiner Department, Toxicology Laboratory, 1851 NW 10th Ave., Miami, USA.

The (±)-threo-4-fluoromethylphenidate (4F-MPH) is a fluorinated analog of the prescription central nervous system stimulant medication, methylphenidate. This novel psychoactive substance was first detected in drug paraphernalia at the Miami-Dade County Medical Examiner Department Toxicology Laboratory in 2016 but was not detected in a biological specimen until 2018. Limited literature is available on 4F-MPH, with predominate literature being published out of Europe, and no known toxicities reported in the USA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jat/bkz061DOI Listing
September 2019

Protein kinase Cδ mediates methamphetamine-induced dopaminergic neurotoxicity in mice via activation of microsomal epoxide hydrolase.

Food Chem Toxicol 2019 Nov 15;133:110761. Epub 2019 Aug 15.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. Electronic address:

We previously demonstrated that activation of protein kinase Cδ (PKCδ) is critical for methamphetamine (MA)-induced dopaminergic toxicity. It was recognized that microsomal epoxide hydrolase (mEH) also induces dopaminergic neurotoxicity. It was demonstrated that inhibition of PKC modulates the expression of mEH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2019.110761DOI Listing
November 2019
4 Reads
2.895 Impact Factor

Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2.

Mol Pharmacol 2019 10 13;96(4):493-504. Epub 2019 Aug 13.

Research Service, Veterans Affairs Portland Health Care System, Portland, Oregon (X.S., T.L.S., N.B.M., A.J.E., A.J.); and The Methamphetamine Abuse Research Center (X.S., A.J.) and Departments of Psychiatry (X.S., T.L.S., A.J.E., A.J.) and Behavioral Neuroscience (N.B.M., A.J.E., A.J.), Oregon Health and Science University, Portland, Oregon

Methamphetamine (MA) is highly addictive and neurotoxic, causing cell death in humans and in rodent models. MA, along with many of its analogs, is an agonist at the G protein-coupled trace amine-associated receptor 1 (TAAR1). TAAR1 activation protects against MA-induced degeneration of dopaminergic neurons, suggesting that TAAR1 plays a role in regulating MA-induced neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.119.116798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744391PMC
October 2019
4 Reads

False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology.

J Anal Toxicol 2020 Mar;44(2):200-205

Service de Toxicologie, Hôpital Lariboisière, AP-HP, 2 Rue Ambroise Paré, Paris 75010, France.

Amphetamines, frequently used recreational drugs with high risk of toxicity, are commonly included in urine drug screens. This screening is based on enzyme immunoassay, which is a quick and easy-to-perform technique, but may lack specificity resulting from cross-reactivity with other compounds, causing false positive results. We present two cases of presumed false positive MULTIGENT® amphetamine/methamphetamine and MULTIGENT® ecstasy (Abbott®) immunoassays with the beta-blocker metoprolol. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jat/advance-article/doi/10.1093/jat
Publisher Site
http://dx.doi.org/10.1093/jat/bkz051DOI Listing
March 2020
3 Reads

The Impact of Substance Abuse on Heart Failure Hospitalizations.

Am J Med 2020 02 29;133(2):207-213.e1. Epub 2019 Jul 29.

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego. Electronic address:

Background: The burden of substance abuse among patients with heart failure and its association with subsequent emergency department visits and hospital admissions are poorly characterized.

Methods: We evaluated the medical records of patients with a diagnosis of heart failure treated at the University of California-San Diego from 2005 to 2016. We identified substance abuse via diagnosis codes or urine drug screens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2019.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980459PMC
February 2020
2 Reads

[Development of High-resolution Methods for the Analysis of Drug Distribution in Biological Tissue Samples and Their Applications].

Authors:
Kenji Kuwayama

Yakugaku Zasshi 2019 ;139(8):1063-1070

National Research Institute of Police Science.

The abuse of drugs has become a serious social problem worldwide. Amphetamine-type stimulants such as methamphetamine are recreationally abused and can cause toxic effects in the body. Unfortunately, death from drug poisoning can occur due to careless intake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/yakushi.19-00112DOI Listing
December 2019
7 Reads

Leakage of the blood-brain barrier followed by vasogenic edema as the ultimate cause of death induced by acute methamphetamine overdose.

Int Rev Neurobiol 2019 9;146:189-207. Epub 2019 Jul 9.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Methamphetamine (METH) is a potent CNS stimulant that is widely used as a recreational drug. Due to its ability to increase bodily heat production and diminish heat loss due to peripheral vasoconstriction, METH is able to increase brain and body temperature. The hyperthermic effects of METH are potentiated when the drug is used under conditions of psycho-physiological activation and in warm ambient temperatures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.irn.2019.06.010DOI Listing
February 2020
2 Reads

Mephedrone and chemsex: when it stops being a party and becomes a fatal problem.

Int J STD AIDS 2019 09 23;30(10):1028-1030. Epub 2019 Jul 23.

1 Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0956462419857004DOI Listing
September 2019

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats.

J Pharm Pharm Sci 2019 ;22(1):301-312

Department of Pharmaceutical Science and Research, Marshall University School of Pharmacy, Huntington, WV, USA. Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Purpose: Methamphetamine (METH) abuse is associated with hepatic dysfunction related comorbidities such as HIV, hepatitis C, and polysubstance abuse with acetaminophen-containing opioid formulations. We aimed to develop a bile duct ligation (BDL)-induced hepatic dysfunction model for studying both METH and experimental treatments for METH abuse in this comorbidity.

Methods: Sham or BDL surgery was performed in male Wistar rats on day 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18433/jpps30471DOI Listing
January 2019
8 Reads

The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity.

J Pharmacol Exp Ther 2019 10 18;371(1):36-44. Epub 2019 Jul 18.

Research Service, VA Portland Health Care System, Portland, Oregon (N.B.M., T.J.P., A.J.); and Departments of Behavioral Neuroscience (N.B.M., T.J.P., A.J.) and Psychiatry (A.J.), and The Methamphetamine Abuse Research Center (T.J.P., A.J.), Oregon Health & Science University, Portland, Oregon

Methamphetamine (MA) impairs vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function and expression, increasing intracellular DA levels that lead to neurotoxicity. The trace amine-associated receptor 1 (TAAR1) is activated by MA, but when the receptor is not activated, MA-induced neurotoxicity is increased. To investigate interactions among TAAR1, VMAT2, and DAT, transporter function and expression were measured in transgenic knockout (KO) and wild-type (WT) mice 24 hours following a binge-like regimen (four intraperitoneal injections, 2 hours apart) of MA (5 mg/kg) or the same schedule of saline treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.119.258970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750185PMC
October 2019

Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms.

Molecules 2019 Jul 16;24(14). Epub 2019 Jul 16.

Unit of Research "Neurobehavioural mechanisms and endophenotypes of addictive behavior", Department of Psychobiology, University of Valencia, Avda. Blasco Ibañez 21, 46010 Valencia, Spain.

Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs, mainly cocaine and methamphetamine (METH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24142583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680550PMC
July 2019
2 Reads

The role of chaperone-mediated autophagy in neurotoxicity induced by alpha-synuclein after methamphetamine exposure.

Brain Behav 2019 08 9;9(8):e01352. Epub 2019 Jul 9.

School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Introduction: Chaperone-mediated autophagy (CMA) is an autophagy-lysosome pathway (ALP) that is different from the other two lysosomal pathways, namely, macroautophagy and microautophagy, and can selectively degrade cytosolic proteins in lysosomes without vesicle formation. CMA activity declines in neurodegenerative diseases such as Parkinson's disease, and similar neurotoxicity can occur after methamphetamine (METH) treatment. The relationship between CMA and METH-induced neurotoxicity is not clear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/brb3.1352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710200PMC
August 2019
5 Reads

Effects of combined toxicity of methamphetamine and ketamine on apoptosis, oxidative stress and genotoxicity in HepG2 cells.

Food Chem Toxicol 2019 Oct 29;132:110653. Epub 2019 Jun 29.

School of Environment, Jinan University, Guangzhou, 510632, People's Republic of China. Electronic address:

Methamphetamine (MA) and ketamine (KET) are widely abused drugs individually. Previous surveys have revealed that the combined consumption of MA and KET were prevalent in illicit drugs abusers. However, few studies on the toxic effects induced by the combination of MA and KET have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2019.110653DOI Listing
October 2019
6 Reads

Identification of cytotoxic markers in methamphetamine treated rat C6 astroglia-like cells.

Sci Rep 2019 06 28;9(1):9412. Epub 2019 Jun 28.

College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, 32307, USA.

Methamphetamine (METH) is a powerfully addictive psychostimulant that has a pronounced effect on the central nervous system (CNS). The present study aimed to assess METH toxicity in differentiated C6 astroglia-like cells through biochemical and toxicity markers with acute (1 h) and chronic (48 h) treatments. In the absence of external stimulants, cellular differentiation of neuronal morphology was achieved through reduced serum (2. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-45845-1
Publisher Site
http://dx.doi.org/10.1038/s41598-019-45845-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599005PMC
June 2019
6 Reads

The Elephant in the Room: Outbreak of Carfentanil Deaths in Minnesota and the Importance of Multiagency Collaboration.

Acad Forensic Pathol 2018 Sep 31;8(3):729-737. Epub 2018 Aug 31.

Over a three-month period in early 2017, the Hennepin County Medical Examiner's Office investigated nine apparent opioid toxicity deaths that occurred in three separate urban, suburban, and rural counties in our jurisdiction. All decedents were known substance abusers and had reportedly recently used heroin; most were found with drug paraphernalia. Complete autopsies variably showed classic stigmata of opioid overdose with no significant injury or natural disease to explain death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1925362118797746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490590PMC
September 2018
9 Reads

Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects.

Dev Neurosci 2019 18;41(1-2):44-55. Epub 2019 Jun 18.

Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA,

Methamphetamine (MA) abuse is a worldwide issue that produces health and cognitive effects in the user. MA is abused by some women who then become pregnant and expose their developing child to the drug. Preclinical rodent models demonstrate cognitive deficits following developmental MA exposure, an effect observed in children exposed to MA in utero. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786264PMC
March 2020
2 Reads

Environmentally relevant concentrations of methamphetamine and sertraline modify the behavior and life history traits of an aquatic invertebrate.

Aquat Toxicol 2019 Aug 11;213:105222. Epub 2019 Jun 11.

University of South Bohemia in České Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.

Pharmaceutically active compounds are major contaminants of aquatic environments that show direct and indirect effects on aquatic organisms even at low concentrations. The aim of this study was to assess the effects of the illicit drug methamphetamine and the antidepressant sertraline on clonal marbled crayfish Procambarus virginalis. Crayfish exposed to the environmentally relevant concentrations of methamphetamine of ∼1 μg L did not exhibit significant differences from unexposed controls in distance moved, velocity, and activity level with or without available shelter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.105222DOI Listing
August 2019
5 Reads

Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease.

Neurotox Res 2019 Nov 18;36(4):724-735. Epub 2019 Jun 18.

Applied Neuroscience Research Group, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Methamphetamine (METH) abuse is known to increase the risk of Parkinson's disease (PD) due to its dopaminergic neurotoxicity. This is the rationale for the METH model of PD developed by toxic METH dosing (10 mg/kg four times every 2 h) which features robust neurodegeneration and typical motor impairment in mice. In this study, we used diffusion kurtosis imaging to reveal microstructural brain changes caused by METH-induced neurodegeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-019-00068-0DOI Listing
November 2019
1 Read

The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice.

Neurotox Res 2019 Aug 14;36(2):376-386. Epub 2019 Jun 14.

Wuhan Institutes of Biomedical Sciences, Jianghan University, Triangle Lake Road No.8, Wuhan, 430056, China.

Repeated methamphetamine (METH) exposure can cause severe neurotoxicity to the central nervous system, and lead to memory deficits. L-Stepholidine (L-SPD) is a structurally identified alkaloid extract of the Chinese herb Stephania intermedia, which elicits dopamine (DA) D1-type receptors partial agonistic activity and D2-type receptors antagonistic activity. In this study, we investigated the effect of L-SPD on METH-induced memory deficits in mice and its underlying mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-019-00069-zDOI Listing
August 2019
1 Read