1,693 results match your criteria Toxicity Methamphetamine


Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants.

Neurochem Int 2019 Mar 14;124:162-170. Epub 2019 Jan 14.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Republic of Korea. Electronic address:

The abuse of methamphetamine (MA), an amphetamine (AMPH)-type stimulant, has been demonstrated to be associated with various neuropsychotoxicity, including memory impairment, psychiatric morbidity, and dopaminergic toxicity. Compelling evidence from preclinical studies has indicated that protein kinase C (PKC), a large family of serine/threonine protein kinases, plays an important role in MA-induced neuropsychotoxicity. PKC-mediated N-terminal phosphorylation of dopamine transporter has been identified as one of the prerequisites for MA-induced synaptic dopamine release. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183054
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.014DOI Listing
March 2019
4 Reads

mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems.

Oxid Med Cell Longev 2018 29;2018:6124745. Epub 2018 Oct 29.

Department of Translational Research and New Technologies in Medicine and Surgery, Human Anatomy, University of Pisa, Via Roma 55, Pisa 56126, Italy.

Methamphetamine (METH) is abused worldwide, and it represents a threat for public health. METH exposure induces a variety of detrimental effects. In fact, METH produces a number of oxidative species, which lead to lipid peroxidation, protein misfolding, and nuclear damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/6124745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311854PMC
February 2019
1 Read

Methamphetamine presentations to an emergency department: Management and complications.

Emerg Med Australas 2018 Dec 28. Epub 2018 Dec 28.

Clinical Toxicology Unit and Emergency Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Objective: There is little recent published data characterising methamphetamine intoxication. The present study aims to describe the clinical effects, management, complications and disposition of patients with methamphetamine exposure.

Methods: This is a retrospective review of patients presenting with methamphetamine intoxication to an ED in 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1742-6723.13219DOI Listing
December 2018
3 Reads

Sympathomimetic amine compounds and hepatotoxicity: Not all are alike-Key distinctions noted in a short review.

Authors:
Cyril Willson

Toxicol Rep 2019 1;6:26-33. Epub 2018 Dec 1.

EuSci LLC, Gretna, NE, USA.

Sympathomimetic amine compounds are often pooled together and incorrectly assumed to be interchangeable with respect to potential adverse effects. A brief and specific review of sympathomimetic compounds and one instance (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxrep.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288410PMC
December 2018
2 Reads

Methamphetamine neurotoxicity, microglia, and neuroinflammation.

J Neuroinflammation 2018 Dec 12;15(1):341. Epub 2018 Dec 12.

Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, JHM Health Science Center, PO Box 100244, Gainesville, FL, 32610, USA.

Methamphetamine (METH) is an illicit psychostimulant that is subject to abuse worldwide. While the modulatory effects of METH on dopamine neurotransmission and its neurotoxicity in the central nervous system are well studied, METH's effects on modulating microglial neuroimmune functions and on eliciting neuroinflammation to affect dopaminergic neurotoxicity has attracted considerable attention in recent years. The current review illuminates METH-induced neurotoxicity from a neuropathological perspective by summarizing studies reporting microglial activation after METH administration in rodents. Read More

View Article

Download full-text PDF

Source
https://jneuroinflammation.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s12974-018-1385-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292109PMC
December 2018
6 Reads

Detection of Cutting Agents in Drug-Positive Seized Exhibits within the United States.

J Forensic Sci 2018 Nov 28. Epub 2018 Nov 28.

The Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, 19090.

The following report summarizes a study performed on seized drug exhibits collected in two U.S. states to evaluate the presence and identification of cutting agents. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/1556-4029.13968
Publisher Site
http://dx.doi.org/10.1111/1556-4029.13968DOI Listing
November 2018
8 Reads

Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol.

J Mol Neurosci 2019 Jan 23;67(1):1-15. Epub 2018 Nov 23.

College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, University of Toledo, Health Science Campus, 3000 Arlington Avenue, HEB 282G, Toledo, OH, 43614, USA.

Evidence demonstrated that the glutamatergic system is implicated in mediating relapse to several drugs of abuse, including methamphetamine (METH). Glutamate homeostasis is maintained by a number of glutamate transporters, such as glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). In addition, group II metabotropic glutamate receptors (mGluR2/3) were found to be implicated in relapse-seeking behavior. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-018-1194-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344243PMC
January 2019
10 Reads

Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.

Toxicol Lett 2019 Feb 19;301:79-89. Epub 2018 Nov 19.

Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany. Electronic address:

New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify cytotoxic potential of NPS based on a high content screening assay (HCSA) using HepG2 cell line and four fluorescent dyes, namely Hoechst33342, TMRM, CAL-520, and TOTO-3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.11.007DOI Listing
February 2019
9 Reads

Hydrogen Sulfide Protects Hippocampal Neurons Against Methamphetamine Neurotoxicity Via Inhibition of Apoptosis and Neuroinflammation.

J Mol Neurosci 2019 Jan 19;67(1):133-141. Epub 2018 Nov 19.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Methamphetamine (METH) known as a highly neurotoxic compound associated with irreversible brain cell damage that results in neurological and psychiatric abnormalities. The mechanisms of METH intoxication mainly involve intraneuronal events including oxidative stress, excitotoxicity, and dopamine oxidation. Based on recent studies, HS can protect neurons through anti-inflammatory, antioxidant, and antiapoptotic mechanisms. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12031-018-1218-8
Publisher Site
http://dx.doi.org/10.1007/s12031-018-1218-8DOI Listing
January 2019
11 Reads

Metabolomics predicts the pharmacological profile of new psychoactive substances.

J Psychopharmacol 2018 Nov 19:269881118812103. Epub 2018 Nov 19.

1 Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Background:: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited and, given the large number of new compounds released on the market each year, their timely evaluation by current standards is certainly challenging.

Aims:: We present here a metabolomics-targeted approach to predict the pharmacological profile of NPS. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0269881118812103
Publisher Site
http://dx.doi.org/10.1177/0269881118812103DOI Listing
November 2018
23 Reads
3.593 Impact Factor

Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters.

Psychopharmacology (Berl) 2018 Nov 5. Epub 2018 Nov 5.

Research Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Rd., Portland, OR, 97239, USA.

Rationale: New psychoactive substances (NPSs), including substituted cathinones and other stimulants, are synthesized, sold on the Internet, and ingested without knowledge of their pharmacological activity and/or toxicity. In vitro pharmacology plays a role in therapeutic drug development, drug-protein in silico interaction modeling, and drug scheduling.

Objectives: The goal of this research was to determine mechanisms of action that may indicate NPS abuse liability. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00213-018-5059-5
Publisher Site
http://dx.doi.org/10.1007/s00213-018-5059-5DOI Listing
November 2018
6 Reads

Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.

Toxicol Lett 2019 Feb 28;301:53-63. Epub 2018 Oct 28.

Department of Pharmacology, School of Medicine, Southeast University, Nanjing, Jiangsu, China; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, Jiangsu, China. Electronic address:

Nod-like Receptor Protein 3 (NLRP3) inflammasome activation is known to lead to microglia-mediated neuroinflammation. Methamphetamine is known to induce microglial activation. However, whether NLRP3 inflammasome activation contributes to the microglial activation induced by methamphetamine remains elusive. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03784274183202
Publisher Site
http://dx.doi.org/10.1016/j.toxlet.2018.10.020DOI Listing
February 2019
13 Reads
3.262 Impact Factor

Methamphetamine exposure induces neuropathic protein β-Amyloid expression.

Toxicol In Vitro 2019 Feb 24;54:304-309. Epub 2018 Oct 24.

Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 211166, China; China International Cooperation Center for Environment and Human Health, China. Electronic address:

Methamphetamine (METH) abusing contributes to dopaminergic neurons degeneration, resulting inParkinson's disease (PD)-like changes. More recently, the association between METH exposure and the Alzheimer's disease (AD)-like changes gained more attention, however, the underlying mechanisms remain poorly understood. In the present study, we aimed to investigate whether METH exposure promotes the formation of Aβ, one of the key AD-like pathological proteins. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08872333183044
Publisher Site
http://dx.doi.org/10.1016/j.tiv.2018.10.012DOI Listing
February 2019
6 Reads

An early warning system for emerging drugs of concern in the emergency department: Protocol for the Western Australian Illicit Substance Evaluation (WISE) study.

Emerg Med Australas 2018 Oct 14. Epub 2018 Oct 14.

Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia.

Objective: An ever-increasing number of novel psychoactive substances are being detected worldwide. These emerging drugs have been demonstrated to cause toxicity in clusters, and deaths have been reported. We urgently need to learn more about their effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1742-6723.13185DOI Listing
October 2018
7 Reads

Impacts of methamphetamine and ketamine on C.elegans's physiological functions at environmentally relevant concentrations and eco-risk assessment in surface waters.

J Hazard Mater 2019 Feb 22;363:268-276. Epub 2018 Sep 22.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

In this work, C. elegans as a model organism was treated with methamphetamine (METH) and ketamine (KET) to assess its eco-toxicity at a range (0.05-250 μg L) that covers environmentally relevant concentrations (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2018.09.020DOI Listing
February 2019
1 Read

Potential pro-oxidative effects of single dose of mephedrone in vital organs of mice.

Pharmacol Rep 2018 Dec 29;70(6):1097-1104. Epub 2018 May 29.

Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland. Electronic address:

Background: Mephedrone is a recreationally used synthetic cathinone, relatively new abusive substances with molecular structure similar to amphetamine. As there is still lack of scientific data regarding mechanisms of action as well as metabolism of mephedrone, especially in aspects other than neurotoxicity, addiction or behavioral changes, therefore we aimed, for the first time, to investigate potential pro-oxidative actions of a single dose of mephedrone in organs other than brain and its structures, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2018.05.010DOI Listing
December 2018
11 Reads

GABAergic Alterations in the Rat Testis after Methamphetamine Exposure.

Int J Med Sci 2018 10;15(12):1349-1354. Epub 2018 Aug 10.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

Gamma-aminobutyric acid (GABA), GABA-A receptors and GABA transporter 1 (GAT1) were reported to be involved in the proliferation of Leydig cells, testosterone production and spermatogenesis. Since methamphetamine (METH) has been reported to have adverse effects on testis and its functions, the aim of this study was therefore to determine the changes of GABAergic activity in testis after METH exposure. Male Sprague-Dawley rats were divided into control, acute binge (AB-METH), escalating dose (ED METH) and escalating dose-binge (ED-binge METH) groups. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v15p1349.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.27609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158670PMC
January 2019
12 Reads

HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling.

Toxicol Lett 2018 Dec 24;299:159-171. Epub 2018 Sep 24.

CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address:

Methamphetamine (Meth) is an addictive psychostimulant whose abuse is intimately linked to increased risks for HIV-1 infection. Converging lines of evidence indicate that Meth also aggravates the symptoms of HIV-associated neurocognitive disorders (HAND), though the underlying mechanisms remain poorly understood. By using the lipophilic antioxidant N-acetylcysteine amide (NACA) as an interventional agent, we examined the roles of oxidative stress in autophagy and apoptosis induced by HIV-Tat (the transactivator of transcription), Meth or their combined treatment in human SH-SY5Y neuroblastoma cells and in the rat striatum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.09.009DOI Listing
December 2018
20 Reads
3.260 Impact Factor

Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT receptors.

Biochem Pharmacol 2018 Dec 25;158:27-34. Epub 2018 Sep 25.

Research Service, VA Portland Health Care System, Portland, OR 97239, United States; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States; Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, United States; The Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR 97239, United States.

The use of new psychoactive substituted 2,5-dimethoxy-N-benzylphenethylamines is associated with abuse and toxicity in the United States and elsewhere and their pharmacology is not well known. This study compares the mechanisms of action of 2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe), 2-(4-ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25E-NBOMe), 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25H-NBOMe), 2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol (25I-NBOH); and 2-(2,5-dimethoxy-4-nitrophenyl)-N-(2-methoxybenzyl)ethanamine) (25N-NBOMe) with hallucinogens and stimulants. Mammalian cells heterologously expressing 5-HT, 5-HT, 5-HT or 5-HT receptors, or dopamine, serotonin or norepinephrine transporters (DAT, SERT and NET, respectively) were used to assess drug affinities at radioligand binding sites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2018.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298744PMC
December 2018
9 Reads

Severe neurologic and hepatic toxicity in a newborn prenatally exposed to methamphetamine. A case report.

Brain Dev 2019 Feb 10;41(2):191-194. Epub 2018 Sep 10.

Neonatology and Neonatal Intensive Care Unit, San Salvatore Hospital, L'Aquila, Italy.

Objective: In the recent years the increase of methamphetamines (MTA) abusers women has become an emerging problem. Very little data has been published regarding the effects of prenatal MTA exposure. We describe a case of MTA related toxicity in a term newborn which have early onset of neonatal encephalopathy and liver failure. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604183043
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2018.08.010DOI Listing
February 2019
16 Reads

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors.

Front Mol Neurosci 2018 29;11:307. Epub 2018 Aug 29.

Department of Applied Life Sciences, Graduate School, Konkuk University, Chungju, South Korea.

Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Although many studies on NDDs have been conducted, their exact pathophysiological characteristics are still not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123546PMC
August 2018
2 Reads

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress.

Oxid Med Cell Longev 2018 22;2018:4982453. Epub 2018 Jul 22.

Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Pisa, Italy.

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field of drug abuse since it allows getting an insight into the molecular mechanisms which operate in a variety of neuropsychiatric disorders. In fact, key alterations produced by methamphetamine involve dopamine neurotransmission in a way, which is reminiscent of spontaneous neurodegeneration and psychiatric schizophrenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/4982453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081569PMC
October 2018
8 Reads

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Nat Biotechnol 2018 Oct 20;36(9):865-874. Epub 2018 Aug 20.

Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes and conversions over the NVU rely on interactions between brain microvascular endothelium, perivascular pericytes, astrocytes and neurons, making it difficult to identify the contributions of each cell type. Here we model the human NVU using microfluidic organ chips, allowing analysis of the roles of individual cell types in NVU functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.4226DOI Listing
October 2018
19 Reads

Dissociation between hypothermia and neurotoxicity caused by mephedrone and methcathinone in TPH2 knockout mice.

Psychopharmacology (Berl) 2018 Aug 3. Epub 2018 Aug 3.

Research & Development Service, John D. Dingell VA Medical Center, R&D Service (11R), 4646 John R, Detroit, MI, 48201, USA.

Rationale: Mephedrone is a commonly abused constituent of "bath salts" and has many pharmacological effects in common with methamphetamine. Despite their structural similarity, mephedrone differs significantly from methamphetamine in its effects on core body temperature and dopamine nerve endings. The reasons for these differences remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-018-4991-8DOI Listing
August 2018
3 Reads

Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011-2014).

Vet Med (Auckl) 2017 30;8:77-85. Epub 2017 Oct 30.

Emergency and Critical Care, Animal Specialty Group, Los Angeles, CA, USA,

The objective of this retrospective study was to describe the responses to treatment with intravenous lipid emulsion (ILE) and the outcomes for a variety of severe intoxications. This case series includes 10 client-owned animals, 9 dogs and 1 cat, that underwent treatment with ILE for a variety of severe intoxications over a 4-year period. History, physical examination findings, clinical signs, clinicopathological test results, treatment, response to treatment, and outcome were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/VMRR.S129576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042488PMC
October 2017
4 Reads

Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.

Cell Prolif 2018 Oct 28;51(5):e12476. Epub 2018 Jun 28.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Objectives: Methamphetamine (MA) abuse evokes pulmonary toxicity. The aim of our study is to investigate if autophagy is induced by MA and if autophagy-initiated apoptosis in alveolar epithelial cells is involved in MA-induced chronic pulmonary toxicity.

Materials And Methods: The rats in Control group and MA group were tested by Doppler and HE staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cpr.12476DOI Listing
October 2018
11 Reads

Methamphetamine toxicity-induced calcineurin activation, nuclear translocation of nuclear factor of activated T-cells and elevation of cyclooxygenase 2 levels are averted by calpastatin overexpression in neuroblastoma SH-SY5Y cells.

Neurotoxicology 2018 07 23;67:287-295. Epub 2018 Jun 23.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, 73170, Thailand. Electronic address:

Methamphetamine (METH) is an addictive stimulant drug that has many negative consequences, including toxic effects to the brain. Recently, the induction of inflammatory processes has been identified as a potential contributing factor to induce neuronal cell degeneration. It has been demonstrated that the expression of inflammatory agents, such as cyclooxygenase 2 (COX-2), depends on the activation of calcineurin (CaN) and nuclear factor of activated T-cells (NFAT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2018.06.011DOI Listing
July 2018
15 Reads

The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment.

Front Mol Neurosci 2018 4;11:186. Epub 2018 Jun 4.

Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, China.

Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the accurate mechanism of toxic effect of the drug on central nervous system (CNS) has not yet been completely deciphered. Besides, effective treatment strategies toward METH neurotoxicity remain scarce and more efficacious drugs are to be developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994595PMC
June 2018
7 Reads

Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of -Hydroxymethamphetamine.

Drug Metab Dispos 2018 09 18;46(9):1277-1284. Epub 2018 Jun 18.

Departments of Pharmaceutics (D.J.W., L.M.S., D.D.S., J.W.) and Pharmacy (S.A.), University of Washington, Seattle, Washington

Methamphetamine is one of the most widely abused illicit drugs. Although human intoxication and multiple tissue toxicities frequently occur in abusers, little is known about the distribution of methamphetamine or its primary metabolites, amphetamine and -hydroxymethamphetamine (-OHMA), to their sites of toxicity. This study determined the pharmacokinetics, tissue exposure, and partition ratios of methamphetamine and major metabolites in various mouse tissues and investigated the impact of organic cation transporter 3 (Oct3) following i. Read More

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0821
Publisher Site
http://dx.doi.org/10.1124/dmd.118.082131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081671PMC
September 2018
16 Reads

Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats.

Int J Pharm 2018 Sep 7;548(1):1-14. Epub 2018 Jun 7.

Department of Morphology, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil; Post-Graduation Programme in Structural and Functional Biology, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil; Post-Graduation Programme in Health Science, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil. Electronic address:

This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.06.008DOI Listing
September 2018
2 Reads

Does Repeated Methamphetamine Exposure at Different Regimens Cause Parkinsonian-Like Behavior in Rats?

Iran J Pharm Res 2018 ;17(2):543-552

Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Methamphetamine (MA), a highly addictive psychostimulant, produces long-lasting neurotoxic effects well proven in nigrostriatal dopaminergic neurons. Considering the similarities between pathological profile of MA neurotoxicity and Parkinson's disease (PD), some reports show that previous MA abusers will be at greater risk of PD-like motor deficits. To answer the question if repeated MA exposure causes parkinsonian-like behavior in rats, we used three regimens of MA administration and assessed the motor performance parameters immediately and over a long period after MA discontinuation. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985172PMC
January 2018
6 Reads

Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.

ACS Chem Neurosci 2018 Nov 1;9(11):2701-2712. Epub 2018 Jun 1.

Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase catalytic subunits are much more promiscuous in their ability to dephosphorylate substrates. To obtain substrate specificity, serine/threonine phosphatases utilize targeting proteins to regulate phosphatase subcellular localization and catalytic activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.8b00144DOI Listing
November 2018
2 Reads

Autophagy plays a pro-survival role against methamphetamine-induced apoptosis in H9C2 cells.

Toxicol Lett 2018 Sep 12;294:156-165. Epub 2018 May 12.

Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tian Yuan East Road, Nanjing, Jiangsu, 211166, China. Electronic address:

Methamphetamine (METH) is a commonly abused psychostimulant that can induce severe neurotoxicity. Cardiovascular injury caused by METH has recently gained increasing attention; however, the underlying mechanisms remain unclear. As autophagy has been shown to be associated with cell injury, the association between autophagy and METH-mediated cell apoptosis was investigated in the present study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03784274183020
Publisher Site
http://dx.doi.org/10.1016/j.toxlet.2018.05.017DOI Listing
September 2018
10 Reads

The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats.

Neurotox Res 2018 Oct 30;34(3):525-537. Epub 2018 Apr 30.

Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna, 31-343, Kraków, Poland.

According to the European Drug Report (2016), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last years. Studies in humans indicate that psychostimulant drug use in adolescence increases risk of drug abuse in adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release to the synaptic cleft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-018-9908-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154178PMC
October 2018
5 Reads

Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

Behav Brain Res 2018 09 27;349:73-79. Epub 2018 Apr 27.

Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbr.2018.04.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320247PMC
September 2018
3 Reads

CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway.

Toxicol Lett 2018 Aug 26;292:97-107. Epub 2018 Apr 26.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

Overexposure to methamphetamine (METH) causes apoptosis in a number of cell types, particularly neuronal cells. However, the underlying mechanisms of METH-induced neuronal apoptosis remain to be elucidated. Accumulation of microtubule-associated protein Tau can lead to activation of multiple neurotoxic pathways, which is closely correlated with neuronal apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.04.027DOI Listing
August 2018
40 Reads

Quantification of Methamphetamine «Shabu» in Biological Matrices to Detect Prenatal Exposure: A Case Report and a Literature Review.

Curr Pharm Biotechnol 2018 ;19(2):163-174

Drug Testing Consultants, #801 265 Russell Hill Road, Toronto, ON, M4V2T3, Canada.

Background: Methamphetamine misuse represents an increasing global public health problem. Its consumption during pregnancy becomes a relevant issue, since it has clinical consequences for the child's health and the pregnant woman. Despite this, there are only few data in the literature that include analytical results in the matrices used to detect prenatal exposure. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/161634/article
Publisher Site
http://dx.doi.org/10.2174/1389201019666180427111735DOI Listing
October 2018
13 Reads

Protective Effects of Ginsenoside Rb1 against Blood-Brain Barrier Damage Induced by Human Immunodeficiency Virus-1 Tat Protein and Methamphetamine in Sprague-Dawley Rats.

Am J Chin Med 2018 ;46(3):551-566

† School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, P. R. China.

Although antiretroviral therapy has helped to improve the lives of individuals infected with human immunodeficiency virus 1 (HIV-1), these patients are often still afflicted with HIV-1-associated neurocognitive disorders, which can lead to neurocognitive impairment and even dementia, and continue to hamper their quality of life. Methamphetamine abuse in HIV-1 patients poses a potential risk for HIV-associated neurocognitive disorders, because methamphetamine and HIV-1 proteins such as transactivator of transcription can synergistically damage the blood-brain barrier (BBB). In this study, we aimed to examine the effects of methamphetamine and HIV-1 Tat protein on the blood-brain barrier function and to determine whether ginsenoside Rb1 (GsRb1) plays a role in protecting the BBB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X18500283DOI Listing
July 2018
23 Reads

Exposure to Far Infrared Ray Protects Methamphetamine-Induced Behavioral Sensitization in Glutathione Peroxidase-1 Knockout Mice via Attenuating Mitochondrial Burdens and Dopamine D1 Receptor Activation.

Neurochem Res 2018 May 23;43(5):1118-1135. Epub 2018 Apr 23.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Evidence indicates that stress conditions might lead to drug dependence. Recently, we have demonstrated that exposure to far infrared ray (FIR) attenuates acute restraint stress via induction of glutathione peroxidase-1 (GPx-1) gene. We investigated whether FIR affects methamphetamine (MA)-induced behavioral sensitization and whether FIR-mediated pharmacological activity requires interaction between dopamine receptor and GPx-1 gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11064-018-2528-5DOI Listing
May 2018
6 Reads

Effect of methamphetamine exposure on the plasma levels of endothelial-derived microparticles.

Drug Alcohol Depend 2018 05 27;186:219-225. Epub 2018 Mar 27.

Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background: Methamphetamine (Meth), a neurotoxin, induces inflammation, oxidative stress, and triggers endothelial dysfunction and cardiovascular disease which is the second cause of death among individuals with Meth-use disorder. Oxidative stress and inflammation trigger the microparticle (MP) release. These are extracellular vesicles extracted from cell surface and identified in biological fluids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2018.02.015DOI Listing
May 2018
5 Reads

Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates.

Prog Neuropsychopharmacol Biol Psychiatry 2018 07 28;85:46-53. Epub 2018 Mar 28.

Department of Neuroscience, The Scripps Research Institute,USA; VA San Diego Healthcare System, USA; Department of Anesthesiology, University of California San Diego, San Diego, CA, USA. Electronic address:

The detrimental effects of amphetamines on developmental stages of NPCs are limited to rodent brain and it is not known if these effects occur in nonhuman primates which are the focus of the current investigation. Young adult rhesus macaques either experienced MDMA only, a combination of amphetamines (MDMA, MDA and methamphetamine) or no amphetamines (controls) and hippocampal tissue was processed for immunohistochemical analysis.Quantitative stereological analysis showed that intermittent exposure to MDMA or the three amphetamines over 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pnpbp.2018.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962428PMC
July 2018
2 Reads

The care of patients using methamphetamine in the emergency department: Perception of nurses, residents, and faculty.

Subst Abus 2018 Mar 29:1-7. Epub 2018 Mar 29.

a Department of Emergency Medicine , University of California Davis Medical Center , Sacramento , California , USA.

Background: To determine differences in perception between nurses, residents, and faculty regarding characteristics and treatment of patients who use methamphetamine (meth).

Methods: Survey study performed at an urban, university Level I trauma medical center.

Results: A total of 80 nurses, 39 residents, and 45 faculty completed the survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08897077.2018.1449170DOI Listing
March 2018
2 Reads

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice.

Int J Dev Neurosci 2018 Jun 20;67:37-45. Epub 2018 Mar 20.

Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy. However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance. Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijdevneu.2018.03.005DOI Listing
June 2018
19 Reads

Drug- and/or trauma-induced hyperthermia? Characterization of HSP70 and myoglobin expression.

PLoS One 2018 22;13(3):e0194442. Epub 2018 Mar 22.

Rudolf Boehm Institute of Pharmacology and Toxicology, Medical Faculty, University of Leipzig, Leipzig, Germany.

Introduction: Heat shock protein 70 (HSP70) expression could be discussed as an adaption that promotes repair and counteracts cell damage. Myoglobin is released upon muscle damage of several pathways. The purpose of the present study was to determine whether the expression of HSP70 in kidney, heart and brain and of myoglobin in the kidney were associated with the cause of death and the survival times after lethal intoxications with three of the drugs most widely used in our local area (Saxony, Germany) as well as after fatal traumatic brain injury (TBI). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194442PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864017PMC
July 2018
9 Reads

Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum.

Toxicol Lett 2018 Jun 14;289:107-113. Epub 2018 Mar 14.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515 Guangzhou, China. Electronic address:

Methamphetamine (METH) is a widely abused psychostimulant. Lactulose is a non-absorbable sugar, which effectively decreases METH-induced neurotoxicity in rat. However, the exact mechanisms need further investigation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.03.015DOI Listing
June 2018
9 Reads

Overdoses and Substance Toxicity in Patients Admitted to Intensive Care Units in a Midwestern U.S. City.

J Trauma Nurs 2018 Mar/Apr;25(2):87-91

Internal Medicine Residency Program, University of Iowa-Des Moines (Drs Schuring, Dodge, Whitcomb, Wall, and Smith); College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa (Dr Wall); and Pulmonary and Critical Care Medicine, The Iowa Clinic, Des Moines, Iowa (Dr Hicklin).

Toxic exposures with serious outcomes have increased over the last decade. Limited data exists on the pattern and outcomes of overdose-exposure patients requiring intensive care unit (ICU) admission. The primary objective of this study was to characterize the causes, treatments, and outcomes of toxic exposures in a mid-sized Midwestern health system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JTN.0000000000000349DOI Listing
September 2018
8 Reads

Cross-sectional cause of death comparisons for stimulant and opioid mortality in San Francisco, 2005-2015.

Drug Alcohol Depend 2018 04 21;185:305-312. Epub 2018 Feb 21.

San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA, United States; Department of Medicine, Division of HIV, Infectious Disease and Global Health, University of California, San Francisco, CA, United States.

Background: Opioids and stimulants (e.g., cocaine or methamphetamine/amphetamine [MAMP]) are major contributors to acute substance toxicity deaths. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2017.12.030DOI Listing
April 2018
10 Reads

Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity.

BMC Complement Altern Med 2018 Feb 23;18(1):76. Epub 2018 Feb 23.

Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekouwai Street, Haidian district, Beijing, China.

Background: Methamphetamine (METH) is a psychostimulant with high abuse liability that affects the monoamine neurotransmitter systems, particularly the dopamine system. Currently there are no effective medications for the treatment of METH abuse to restore METH-induced dopaminergic dysfunction. The Jitai tablet (JTT), a commercial traditional Chinese medicinal preparation, has been shown to modulate the dopaminergic function both in heroin addicts and in morphine-dependent rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12906-018-2094-zDOI Listing
February 2018
6 Reads

Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor.

J Neuroinflammation 2018 Feb 21;15(1):52. Epub 2018 Feb 21.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.

Background: We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, and that balance between dynorphin and substance P is important for dopaminergic neuroprotection. Thus, we examined whether GRe positively affects interactive modulation between dynorphin and substance P against MA neurotoxicity in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-018-1087-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822489PMC
February 2018
9 Reads
5.410 Impact Factor