1,898 results match your criteria Toxicity Methamphetamine

Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.

J Neurochem 2021 May 15. Epub 2021 May 15.

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.

In Parkinson's disease, dopamine-containing nigrostriatal neurons undergo profound degeneration. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. TH increases in vitro formation of reactive oxygen species, and previous animal studies have reported links between cytosolic dopamine buildup and oxidative stress. Read More

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Neuroprotective Effects of Curcumin in Methamphetamine-Induced Toxicity.

Molecules 2021 Apr 24;26(9). Epub 2021 Apr 24.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy.

Curcumin (CUR), a natural polyphenol extracted from rhizome of the , has received great attention for its multiple potential health benefits as well as disease prevention. For instance, CUR protects against toxic agents acting on the human body, including the nervous system. In detail, CUR possesses, among others, strong effects as an autophagy activator. Read More

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Comment on "Diluted concentrations of methamphetamine in surface water induce behavior disorder, transgenerational toxicity, and ecosystem-level consequences of fish" by Wang et al. [Water Research 184 (2020) 116-164].

Water Res 2021 Jun 25;197:117007. Epub 2021 Mar 25.

University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.

The article presented by Wang et al. (2020) intends to elucidate the possible ecological effects of low (0.05-25 μg L) and higher (100 μg L) concentrations of methamphetamine on adult Oryzias latipes through a battery of assays, including histopathology. Read More

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Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca channels as sensors.

Toxicol Appl Pharmacol 2021 05 27;419:115513. Epub 2021 Mar 27.

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, United States of America. Electronic address:

The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug whose overdose can be fatal. It is a potent substrate at DAT and SERT where its simplest secondary amine (N-methyl 4-MA) retains substrate activity at them. Read More

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Assessment on the adverse effects on different kinds of fish induced by methamphetamine during the natural attenuation process based on adverse outcome pathway.

Sci Total Environ 2021 Mar 19;780:146587. Epub 2021 Mar 19.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, PR China.

The adverse effects on model fish induced by methamphetamine (METH) have been revealed. However, the toxicity of METH on different kinds of non-model fish during the natural attenuation remained unclear. Hence, in this study, we for the first time established a static lab-scale aquatic ecosystem spiked with METH (initial levels at 25 μg/L) for 40 days to estimate its metabolism and toxicity in Chinese medaka, rosy bitterling, loach, and mosquito fish. Read More

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[Organ-Specific Accumulation and Toxicokinetics of Ephedrine in Adult Zebrafish ()].

Huan Jing Ke Xue 2021 Mar;42(3):1496-1502

Center for Environmental Health Risk Assessment and Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

Ephedrine (EPH) is an alkaloid commonly used to relieve nasal congestion caused by colds, allergic rhinitis, rhinitis, and sinusitis, and to control bronchial asthma. It is also be used as a raw material in the manufacture of methamphetamine. Although the distribution of EPH in surface waters has been widely studied, its uptake, internal distribution, and toxicokinetic processing in exposed organisms have not been well investigated. Read More

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Trends in MDMA-related mortality across four countries.

Addiction 2021 Mar 19. Epub 2021 Mar 19.

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal.

Aims: To determine trends in 3,4 methylenedioxymethamphetamine (MDMA)-related death rates across Australia, Finland, Portugal and Turkey and to analyse the toxicology and causes of death across countries.

Design: Analysis of MDMA-related deaths extracted from a national coronial database in Australia (2001-19) and national forensic toxicology databases in Finland (2001-17), Portugal (2008-19) and Turkey (2007-17). Presentation of MDMA use and seizure data (market indicators). Read More

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A miniaturized giant magnetic resistance system for quantitative detection of methamphetamine.

Analyst 2021 Apr;146(8):2718-2725

School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China.

Point-of-care testing (POCT) systems have been greatly developed in recent years. Among them, lateral flow immunoassay (LFIA) based on magnetic nanoparticles (MNPs) is widely used in various fields due to the advantages of small background noise and good biocompatibility. This paper designed an ultra-sensitive giant magnetic resistance (GMR) system for the quantitative detection of methamphetamine (MET). Read More

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Methamphetamine-related postmortem cases in Jeddah, Saudi Arabia.

Forensic Sci Int 2021 Apr 26;321:110746. Epub 2021 Feb 26.

King Abdul-Aziz Hospital, Laboratory Department, Jeddah, Saudi Arabia. Electronic address:

A more than 500% increase in the number of deaths involving methamphetamine occurred between 2016 and 2018 in Jeddah, Saudi Arabia. As such, this report employed a validated liquid chromatography tandem mass spectrometry method to quantify methamphetamine and its metabolites in bodily fluids from 47 postmortem cases in which methamphetamine was involved. The mean age of the deceased was 33 years old (median: 30, range: 16-63), and 94% were male. Read More

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Aromadendrin Protects Neuronal Cells from Methamphetamine-Induced Neurotoxicity by Regulating Endoplasmic Reticulum Stress and PI3K/Akt/mTOR Signaling Pathway.

Int J Mol Sci 2021 Feb 25;22(5). Epub 2021 Feb 25.

College of Pharmacy, Keimyung University, Daegu 42601, Korea.

Methamphetamine (METH) is a highly addictive drug that induces irreversible damage to neuronal cells and pathological malfunction in the brain. Aromadendrin, isolated from the flowers of , has been shown to have anti-inflammatory or anti-tumor activity. Nevertheless, it has been reported that METH exacerbates neurotoxicity by inducing endoplasmic reticulum (ER) stress via the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway in neuronal cells. Read More

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February 2021

Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology.

Ageing Res Rev 2021 05 18;67:101304. Epub 2021 Feb 18.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; The State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China. Electronic address:

Melatonin (MLT) is a neurohormone that is regulated by the circadian clock and plays multifunctional roles in numerous neurodegenerative disorders, such as Alzheimer's disease (AD). AD is the most common form of dementia and is associated with the degradation of axons and synapses resulting in memory loss and cognitive impairment. Despite extensive research, there is still no effective cure or specific treatment to prevent the progression of AD. Read More

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S-(+)-Pentedrone and R-(+)-methylone as the most oxidative and cytotoxic enantiomers to dopaminergic SH-SY5Y cells: Role of MRP1 and P-gp in cathinones enantioselectivity.

Toxicol Appl Pharmacol 2021 04 18;416:115442. Epub 2021 Feb 18.

UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Cathinone derivatives are the most representative group within new drugs market, which have been described as neurotoxic. Since cathinones, as pentedrone and methylone, are available as racemates, it is our aim to study the neuronal cytotoxicity induced by each enantiomer. Therefore, a dopaminergic SH-SY5Y cell line was used to evaluate the hypothesis of enantioselectivity of pentedrone and methylone enantiomers on cytotoxicity, oxidative stress, and membrane efflux transport (confirmed by in silico studies). Read More

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Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?

Front Pharmacol 2020 20;11:609811. Epub 2021 Jan 20.

Institute of Clinical Pharmacology, University Medical Center Göttingen, Göttingen, Germany.

Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some might also be substrates of polyspecific organic cation transporters (OCTs) that mediate uptake in liver and kidneys for metabolism and excretion. Read More

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January 2021

Ovarian hormones prevent methamphetamine-induced anxiety-related behaviors and neuronal damage in ovariectomized rats.

Neurosci Lett 2021 02 19;746:135652. Epub 2021 Jan 19.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Methamphetamine (METH) may cause long‒lasting neurotoxic effects and cognitive impairment. On the other hand, the ovarian hormones estrogen and progesterone have neuroprotective effects. In the current study, we aimed to examine the effects of estrogen and progesterone on anxiety‒like behavior and neuronal damage in METH‒exposed ovariectomized (OVX) rats. Read More

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February 2021

Potential Contribution of the Intestinal Microbiome to Phenethylamine-Induced Hyperthermia.

Brain Behav Evol 2021 Jan 20:1-16. Epub 2021 Jan 20.

The Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green State University, Bowling Green, Ohio, USA,

Phenethylamines (e.g., methamphetamine) are a common source of drug toxicity. Read More

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January 2021

Public health challenges facing Environmental Health Officers during COVID-19: methamphetamine contamination of properties.

Aust N Z J Public Health 2021 02 18;45(1):9-12. Epub 2021 Jan 18.

College of Science and Engineering, Flinders University, South Australia.

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February 2021

Pediatric Methamphetamine Toxicity: Clinical Manifestations and Therapeutic Use of Antipsychotics-One Institution's Experience.

J Med Toxicol 2021 Apr 13;17(2):168-175. Epub 2021 Jan 13.

Department of Medical Toxicology, Banner - University Medical Center Phoenix, 1012 E Willetta St., 2nd floor, Phoenix, AZ, 85006, USA.

Introduction: Methamphetamine toxicity is common in the Southwest region of the United States and presents diagnostic and treatment challenges in the pediatric population. The aim of our study was to characterize signs and symptoms of methamphetamine toxicity in pediatric patients, highlighting manifestations unique to this population. Additionally, our study sought to evaluate treatment modalities, specifically antipsychotics, in this population with the intent to characterize their adverse effects. Read More

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Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters.

Chem Res Toxicol 2020 Dec 30. Epub 2020 Dec 30.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.

Impairments in the vesicular packaging of dopamine result in an accumulation of dopamine in the cytosol. Cytosolic dopamine is vulnerable to two metabolic processes-enzymatic catabolism and enzymatic- or auto-oxidation-that form toxic metabolites and generate reactive oxygen species. Alterations in the expression or activity of the vesicular monoamine transporter 2 (VMAT2), which transports monoamines such as dopamine from the cytosol into the synaptic vesicle, result in dysregulated dopamine packaging. Read More

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December 2020

TBHQ-Overview of Multiple Mechanisms against Oxidative Stress for Attenuating Methamphetamine-Induced Neurotoxicity.

Oxid Med Cell Longev 2020 27;2020:8874304. Epub 2020 Nov 27.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, China.

Methamphetamine is a derivative of amphetamines, a highly addictive central stimulant with multiple systemic toxicity including the brain, heart, liver, lung, and spleen. It has adverse effects such as apoptosis and breakdown of the blood-brain barrier. Methamphetamine is a fatal and toxic chemical substance, and its lethal mechanism has been widely studied in recent years. Read More

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November 2020

Characterization and treatment challenges of pulmonary hypertension in methamphetamine users.

Respir Med Case Rep 2020 6;31:101275. Epub 2020 Nov 6.

The Oregon Clinic, Division of Pulmonary, Sleep and Critical Care Medicine, 1111 NE 99th Avenue, Suite 200, Portland, OR, 97220, USA.

The World Health Organization pulmonary hypertension classification scheme provides a framework for evaluation and management of patients with pulmonary vascular disease. Methamphetamine is a recreational stimulant which causes cardiac and pulmonary vascular toxicity. We discuss three cases of methamphetamine users who presented with left ventricular systolic failure but on heart failure therapy developed features more consistent with pulmonary arterial hypertension (PAH) or combined pre-capillary and post-capillary pulmonary hypertension. Read More

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November 2020

Melatonin reverts methamphetamine-induced learning and memory impairments and hippocampal alterations in mice.

Life Sci 2021 Jan 2;265:118844. Epub 2020 Dec 2.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, Thailand. Electronic address:

Aims: Methamphetamine (METH) has become a major public health problem because of its abuse and profound neurotoxic effects, causing alterations in brain structure and function, and impairing cognitive functions, including attention, decision making, emotional memory, and working memory. This study aimed to determine whether melatonin (MEL), the circadian-control hormone, which has roles beyond circadian rhythm regulation, could restore METH-induced cognitive and neuronal impairment.

Main Methods: Mice were treated with either METH (1 mg/kg) or saline for 7 days, followed by MEL (10 mg/kg) or saline for another 14 days. Read More

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January 2021

Oral clonazepam versus lorazepam in the treatment of methamphetamine-poisoned children: a pilot clinical trial.

BMC Pediatr 2020 12 3;20(1):543. Epub 2020 Dec 3.

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: To evaluate the efficacy of oral clonazepam versus oral lorazepam following initial parenteral benzodiazepine administration to control methamphetamine-induced agitation in children.

Methods: In a single-center clinical trial, intravenous diazepam (0.2 mg/Kg) was initially administered to all methamphetamine-poisoned pediatric patients to control their agitation, followed by a single dose of oral clonazepam (0. Read More

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December 2020

Long-term outcomes of psychoactive drug use in trauma patients: A multicenter patient-reported outcomes study.

J Trauma Acute Care Surg 2021 02;90(2):319-324

From the Division of Trauma, Emergency Surgery, and Surgical Critical Care (M.E.M., K.B., G.V., H.M.A.K.), Massachusetts General Hospital; Department of Surgery (J.P.H.-E., A.S.), Division of Trauma, Burn and Surgical Critical Care, Brigham and Women's Hospital, Harvard Medical School; Center for Surgery and Public Health (J.P.H.-E., C.O., A.N.H., A.S.), Brigham and Women's Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health; Department of Psychiatry (N.C.L.-C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Division of Trauma, Burn and Critical Care Surgery (D.N.), Harborview Medical Center, University of Washington, Seattle, Washington; Division of Trauma, Acute Care Surgery and Surgical Critical Care (S.E.S.), Boston University School of Medicine, Boston, Massachusetts.

Introduction: Psychoactive drug use (PDU) is reported in up to 40% of trauma patients and is associated with a higher rate of in-hospital complications. However, little is known about its long-term impact on trauma patients. We aimed to assess the long-term functional, mental, and psychosocial outcomes of PDU in trauma patients 6 to 12 months after injury. Read More

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February 2021

An alarming rise in the prevalence of deaths with methamphetamine involved in Tehran, Iran 2011-2018.

Forensic Sci Med Pathol 2021 Jun 25;17(2):208-215. Epub 2020 Nov 25.

Forensic Toxicology Department, Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.

Methamphetamine is one of the most commonly abused illicit drugs in Iran. Despite this fact, there has been relatively little research on methamphetamine-associated deaths in Iran. The present study aimed to investigate the cause of death in methamphetamine positive cases based on forensic toxicology findings In this data base descriptive study, individuals with methamphetamine-associated deaths that were referred to the Legal Medicine Organization, Tehran, Iran (2011-2018) were assessed. Read More

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Methamphetamine pre-exposure induces steeper escalation of methamphetamine self-administration with consequent alterations in hippocampal glutamate AMPA receptor mRNAs.

Eur J Pharmacol 2020 Dec 18;889:173732. Epub 2020 Nov 18.

Molecular Neuropsychiatry Research Branch, DHHS/NIH/NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD, 21224, USA. Electronic address:

Methamphetamine use disorder (MUD) is often modeled using rodent self-administration (SA) experiments. Noncontingent injections of a drug given to rodents before self-administration training can increase drug SA. In the present study, we injected methamphetamine before putting rats through methamphetamine SA to investigate SA escalation. Read More

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December 2020

URB597 abrogates anxiogenic and depressive behaviors in the methamphetamine-withdrawal mice: Role of the cannabinoid receptor type 1, cannabinoid receptor type 2, and transient receptor potential vanilloid 1 channels.

J Psychopharmacol 2020 Nov 6:269881120965934. Epub 2020 Nov 6.

Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.

Background: Methamphetamine is an addictive stimulant that possesses toxicity in the brain when taken repeatedly or at higher doses. Methamphetamine neurotoxicity is associated with numerous forms of mental impairment, including depression and anxiety. Evidence has also demonstrated that the endocannabinoid system is involved in the regulation of anxiety and depression. Read More

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November 2020

Methamphetamine-Induced Open Field Behavior and LD50 in Periplaneta americana Cockroaches (Blattodea: Blattidae).

J Econ Entomol 2021 02;114(1):476-480

Department of Pharmaceutical Science and Research, Marshall University School of Pharmacy, Huntington, WV.

Invertebrate animal studies of methamphetamine (METH) could allow for high throughput, inexpensive, and high-animal number pharmacology and toxicology studies. We hypothesized that in Periplaneta americana cockroaches, METH would increase locomotion compared to saline and produce lethality. Lethal dose, 50% (LD50) was determined with 0-1,780 µg/g (mg/kg) METH (n = 15-16/group) using logit analysis. Read More

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February 2021

Methamphetamine exposure and its cessation alter gut microbiota and induce depressive-like behavioral effects on rats.

Psychopharmacology (Berl) 2021 Jan 23;238(1):281-292. Epub 2020 Oct 23.

Department of Psychology, Texas Institute for Measurement, Evaluation and Statistics (TIMES), University of Houston, Health and Biomedical Sciences Building 1, 4849 Calhoun Road, Houston, TX, 77204-6022, USA.

Rationale: Methamphetamine is a highly abused psychostimulant drug and its use remains a major public health concern worldwide with limited effective treatment options. Accumulative evidence reveals the influence of gut microbiota on the brain, behavior, and health as a part of the gut-brain axis but its involvement in modulating this substance use disorder remains poorly understood.

Objective: We sought to determine whether methamphetamine exposure and cessation or withdrawal alter the intestinal gut microbiota as well as characterize cessation-induced behavioral changes. Read More

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January 2021

Current state of drug analysis in Japanese emergency departments: a nationwide survey.

Acute Med Surg 2020 Jan-Dec;7(1):e566. Epub 2020 Oct 15.

Yonemori Hospital Kagoshima Japan.

Aim: In 1999, the Japanese Society for Clinical Toxicology proposed 15 toxicants that would be useful for analysis: methanol, barbiturates, benzodiazepines, bromovalerylurea, tricyclic acid, acetaminophen, salicylic acid, theophylline, organic phosphorus pesticides, carbamate pesticides, glufosinate, paraquat, arsenic, cyanide, and methamphetamine. We aimed to reveal the current state of drug analysis for acute poisoning in the emergency department of Japanese hospitals.

Methods: From 1 April, 2017, we undertook a questionnaire survey in the emergency departments of 546 hospitals designated as educational institutions for emergency physicians. Read More

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October 2020