1,713 results match your criteria Toxicity Methamphetamine


Host-parasite interaction as a toxicity test endpoint using asymmetrical exposures.

Aquat Toxicol 2019 Apr 8;211:173-180. Epub 2019 Apr 8.

University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.

Interspecific relationships frequently determine the effect a pollutant can have on an organism, and this is especially true in closely interacting species such as hosts and parasites. The high spatial and temporal variability of contaminant concentrations combined with the movement of aquatic biota can further influence the consequences that are associated with contamination. We used a full factorial design for the exposed and unexposed partners of the relationship between the parasitic larvae (glochidia) of the European freshwater mussel (Anodonta anatina) and its host fish (Squalius cephalus) to identify the sources of variation in the sublethal endpoints of species interaction (the intensity of parasite attachment, the spatial position of glochidia on the host body, and encapsulation success). Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.04.006DOI Listing
April 2019
2 Reads

Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling.

Brain Behav Immun 2019 Mar 15. Epub 2019 Mar 15.

Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice 40-065, Poland; Department of Biochemistry and Molecular Biology, University of Miami, School of Medicine, 1011 NW 15th Street, Miami, FL 33136, USA. Electronic address:

Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokines are among the key mediators between systemic inflammatory status and tissue responses. One of these, interleukin 1 (IL-1), has been hypothesized to be involved in cognitive functions and also appears to play a pivotal role among inflammatory molecules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183073
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http://dx.doi.org/10.1016/j.bbi.2019.03.016DOI Listing
March 2019
4 Reads

25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In Vitro.

Neurotox Res 2019 May 26;35(4):993-998. Epub 2019 Feb 26.

Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.

25C-NBOMe is a designer substituted phenethylamine and a high-potency psychedelic that acts on the 5-HT receptor. Although 25C-NBOMe overdoses have been related to several deaths in the USA and Europe, very limited data exists on the in vitro neurotoxicity of 25C-NBOMe. In this study, we found that 25C-NBOMe potently reduced cell viability of SH-SY5Y, PC12, and SN4741 cells, with IC values of 89, 78, and 62 μM, respectively. Read More

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http://link.springer.com/10.1007/s12640-019-0012-x
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http://dx.doi.org/10.1007/s12640-019-0012-xDOI Listing
May 2019
22 Reads

Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR.

Neurotoxicology 2019 Feb 15;72:95-100. Epub 2019 Feb 15.

Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address:

4,4'-Dimethylaminorex (4,4'-DMAR) is a novel psychoactive substance (NPS) that appeared on the illicit drug market in addition to the psychostimulant 4-methylaminorex (4-MAR). Both substances are methylated derivatives of aminorex, an amphetamine-like anorectic used in the 1960ies and withdrawn from the marked due to severe cardiovascular toxicity. The aim of the present study was to characterize the in vitro pharmacological profiles of 4-MAR, 4,4'-DMAR, and 3,4-dimethylaminorex (3,4-DMAR, direx). Read More

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http://dx.doi.org/10.1016/j.neuro.2019.02.011DOI Listing
February 2019
6 Reads

Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants.

Neurochem Int 2019 Mar 14;124:162-170. Epub 2019 Jan 14.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Republic of Korea. Electronic address:

The abuse of methamphetamine (MA), an amphetamine (AMPH)-type stimulant, has been demonstrated to be associated with various neuropsychotoxicity, including memory impairment, psychiatric morbidity, and dopaminergic toxicity. Compelling evidence from preclinical studies has indicated that protein kinase C (PKC), a large family of serine/threonine protein kinases, plays an important role in MA-induced neuropsychotoxicity. PKC-mediated N-terminal phosphorylation of dopamine transporter has been identified as one of the prerequisites for MA-induced synaptic dopamine release. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186183054
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http://dx.doi.org/10.1016/j.neuint.2019.01.014DOI Listing
March 2019
16 Reads

mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems.

Oxid Med Cell Longev 2018 29;2018:6124745. Epub 2018 Oct 29.

Department of Translational Research and New Technologies in Medicine and Surgery, Human Anatomy, University of Pisa, Via Roma 55, Pisa 56126, Italy.

Methamphetamine (METH) is abused worldwide, and it represents a threat for public health. METH exposure induces a variety of detrimental effects. In fact, METH produces a number of oxidative species, which lead to lipid peroxidation, protein misfolding, and nuclear damage. Read More

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http://dx.doi.org/10.1155/2018/6124745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311854PMC
February 2019
2 Reads

Methamphetamine presentations to an emergency department: Management and complications.

Emerg Med Australas 2018 Dec 28. Epub 2018 Dec 28.

Clinical Toxicology Unit and Emergency Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Objective: There is little recent published data characterising methamphetamine intoxication. The present study aims to describe the clinical effects, management, complications and disposition of patients with methamphetamine exposure.

Methods: This is a retrospective review of patients presenting with methamphetamine intoxication to an ED in 2016. Read More

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http://dx.doi.org/10.1111/1742-6723.13219DOI Listing
December 2018
4 Reads

Sympathomimetic amine compounds and hepatotoxicity: Not all are alike-Key distinctions noted in a short review.

Authors:
Cyril Willson

Toxicol Rep 2019 1;6:26-33. Epub 2018 Dec 1.

EuSci LLC, Gretna, NE, USA.

Sympathomimetic amine compounds are often pooled together and incorrectly assumed to be interchangeable with respect to potential adverse effects. A brief and specific review of sympathomimetic compounds and one instance (i.e. Read More

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http://dx.doi.org/10.1016/j.toxrep.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288410PMC
December 2018
3 Reads

The novel psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone): A review.

Forensic Sci Int 2019 Feb 3;295:54-63. Epub 2018 Dec 3.

UCIBIO/REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

3-Methylmethcathinone (3-MMC or metaphedrone) is a synthetic cathinone, recently introduced in the market of the new psychoactive substances (NPS), initially to replace mephedrone (4-methylmethcathinone or 4-MMC), and rapidly widespread among drug users. 3-Methylmethcathinone is legally controlled in many countries, but is still easily available for purchase from websites, and frequently found in recreational settings. Most toxicological data on this drug come from human case reports of intoxications. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.11.024DOI Listing
February 2019
2 Reads

Methamphetamine neurotoxicity, microglia, and neuroinflammation.

J Neuroinflammation 2018 Dec 12;15(1):341. Epub 2018 Dec 12.

Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, JHM Health Science Center, PO Box 100244, Gainesville, FL, 32610, USA.

Methamphetamine (METH) is an illicit psychostimulant that is subject to abuse worldwide. While the modulatory effects of METH on dopamine neurotransmission and its neurotoxicity in the central nervous system are well studied, METH's effects on modulating microglial neuroimmune functions and on eliciting neuroinflammation to affect dopaminergic neurotoxicity has attracted considerable attention in recent years. The current review illuminates METH-induced neurotoxicity from a neuropathological perspective by summarizing studies reporting microglial activation after METH administration in rodents. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1385-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292109PMC
December 2018
7 Reads

Detection of Cutting Agents in Drug-Positive Seized Exhibits within the United States.

J Forensic Sci 2018 Nov 28. Epub 2018 Nov 28.

The Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, 19090.

The following report summarizes a study performed on seized drug exhibits collected in two U.S. states to evaluate the presence and identification of cutting agents. Read More

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http://doi.wiley.com/10.1111/1556-4029.13968
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http://dx.doi.org/10.1111/1556-4029.13968DOI Listing
November 2018
9 Reads

Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol.

J Mol Neurosci 2019 Jan 23;67(1):1-15. Epub 2018 Nov 23.

College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, University of Toledo, Health Science Campus, 3000 Arlington Avenue, HEB 282G, Toledo, OH, 43614, USA.

Evidence demonstrated that the glutamatergic system is implicated in mediating relapse to several drugs of abuse, including methamphetamine (METH). Glutamate homeostasis is maintained by a number of glutamate transporters, such as glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). In addition, group II metabotropic glutamate receptors (mGluR2/3) were found to be implicated in relapse-seeking behavior. Read More

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http://dx.doi.org/10.1007/s12031-018-1194-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344243PMC
January 2019
17 Reads

Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.

Toxicol Lett 2019 Feb 19;301:79-89. Epub 2018 Nov 19.

Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany. Electronic address:

New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify cytotoxic potential of NPS based on a high content screening assay (HCSA) using HepG2 cell line and four fluorescent dyes, namely Hoechst33342, TMRM, CAL-520, and TOTO-3. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.11.007DOI Listing
February 2019
22 Reads

Hydrogen Sulfide Protects Hippocampal Neurons Against Methamphetamine Neurotoxicity Via Inhibition of Apoptosis and Neuroinflammation.

J Mol Neurosci 2019 Jan 19;67(1):133-141. Epub 2018 Nov 19.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Methamphetamine (METH) known as a highly neurotoxic compound associated with irreversible brain cell damage that results in neurological and psychiatric abnormalities. The mechanisms of METH intoxication mainly involve intraneuronal events including oxidative stress, excitotoxicity, and dopamine oxidation. Based on recent studies, HS can protect neurons through anti-inflammatory, antioxidant, and antiapoptotic mechanisms. Read More

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http://link.springer.com/10.1007/s12031-018-1218-8
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http://dx.doi.org/10.1007/s12031-018-1218-8DOI Listing
January 2019
21 Reads

Metabolomics predicts the pharmacological profile of new psychoactive substances.

J Psychopharmacol 2019 Mar 19;33(3):347-354. Epub 2018 Nov 19.

1 Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Background:: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited and, given the large number of new compounds released on the market each year, their timely evaluation by current standards is certainly challenging.

Aims:: We present here a metabolomics-targeted approach to predict the pharmacological profile of NPS. Read More

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http://journals.sagepub.com/doi/10.1177/0269881118812103
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http://dx.doi.org/10.1177/0269881118812103DOI Listing
March 2019
36 Reads
3.593 Impact Factor

Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters.

Psychopharmacology (Berl) 2018 Nov 5. Epub 2018 Nov 5.

Research Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Rd., Portland, OR, 97239, USA.

Rationale: New psychoactive substances (NPSs), including substituted cathinones and other stimulants, are synthesized, sold on the Internet, and ingested without knowledge of their pharmacological activity and/or toxicity. In vitro pharmacology plays a role in therapeutic drug development, drug-protein in silico interaction modeling, and drug scheduling.

Objectives: The goal of this research was to determine mechanisms of action that may indicate NPS abuse liability. Read More

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http://link.springer.com/10.1007/s00213-018-5059-5
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http://dx.doi.org/10.1007/s00213-018-5059-5DOI Listing
November 2018
8 Reads

Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.

Toxicol Lett 2019 Feb 28;301:53-63. Epub 2018 Oct 28.

Department of Pharmacology, School of Medicine, Southeast University, Nanjing, Jiangsu, China; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, Jiangsu, China. Electronic address:

Nod-like Receptor Protein 3 (NLRP3) inflammasome activation is known to lead to microglia-mediated neuroinflammation. Methamphetamine is known to induce microglial activation. However, whether NLRP3 inflammasome activation contributes to the microglial activation induced by methamphetamine remains elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183202
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http://dx.doi.org/10.1016/j.toxlet.2018.10.020DOI Listing
February 2019
20 Reads
3.262 Impact Factor

Methamphetamine exposure induces neuropathic protein β-Amyloid expression.

Toxicol In Vitro 2019 Feb 24;54:304-309. Epub 2018 Oct 24.

Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 211166, China; China International Cooperation Center for Environment and Human Health, China. Electronic address:

Methamphetamine (METH) abusing contributes to dopaminergic neurons degeneration, resulting inParkinson's disease (PD)-like changes. More recently, the association between METH exposure and the Alzheimer's disease (AD)-like changes gained more attention, however, the underlying mechanisms remain poorly understood. In the present study, we aimed to investigate whether METH exposure promotes the formation of Aβ, one of the key AD-like pathological proteins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183044
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http://dx.doi.org/10.1016/j.tiv.2018.10.012DOI Listing
February 2019
8 Reads

An early warning system for emerging drugs of concern in the emergency department: Protocol for the Western Australian Illicit Substance Evaluation (WISE) study.

Emerg Med Australas 2018 Oct 14. Epub 2018 Oct 14.

Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia.

Objective: An ever-increasing number of novel psychoactive substances are being detected worldwide. These emerging drugs have been demonstrated to cause toxicity in clusters, and deaths have been reported. We urgently need to learn more about their effects. Read More

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http://dx.doi.org/10.1111/1742-6723.13185DOI Listing
October 2018
8 Reads

Impacts of methamphetamine and ketamine on C.elegans's physiological functions at environmentally relevant concentrations and eco-risk assessment in surface waters.

J Hazard Mater 2019 Feb 22;363:268-276. Epub 2018 Sep 22.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

In this work, C. elegans as a model organism was treated with methamphetamine (METH) and ketamine (KET) to assess its eco-toxicity at a range (0.05-250 μg L) that covers environmentally relevant concentrations (0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2018.09.020DOI Listing
February 2019
1 Read

Potential pro-oxidative effects of single dose of mephedrone in vital organs of mice.

Pharmacol Rep 2018 Dec 29;70(6):1097-1104. Epub 2018 May 29.

Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland. Electronic address:

Background: Mephedrone is a recreationally used synthetic cathinone, relatively new abusive substances with molecular structure similar to amphetamine. As there is still lack of scientific data regarding mechanisms of action as well as metabolism of mephedrone, especially in aspects other than neurotoxicity, addiction or behavioral changes, therefore we aimed, for the first time, to investigate potential pro-oxidative actions of a single dose of mephedrone in organs other than brain and its structures, i.e. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.05.010DOI Listing
December 2018
14 Reads

The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures.

Neurotoxicology 2018 12 30;69:130-140. Epub 2018 Sep 30.

Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, 72079, AR, USA.

The initial goals of these experiments were to determine: 1) if blood-brain barrier (BBB) breakdown was a cause or an effect of METH-induced seizures; 2) all the brain regions where BBB is disrupted as seizures progress; and 3) the correlations between body temperature and vascular leakage and neurodegeneration. A fourth objective was added after initial experimentation to determine if sub-strain differences existed in adult male C57 B6 J (Jackson laboratories, JAX) versus C57 B6N (Charles River, CR) mice involving their susceptibility to BBB breakdown and seizure severity. With the 1st "maximal" intensity myoclonic-tonic seizure (MCT) varying degrees of IgG infiltration across the BBB (≤1 mm) were prominent in olfactory system (OS) associated regions and in thalamus, hypothalamus and neocortex. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183011
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http://dx.doi.org/10.1016/j.neuro.2018.09.008DOI Listing
December 2018
19 Reads
3.380 Impact Factor

GABAergic Alterations in the Rat Testis after Methamphetamine Exposure.

Int J Med Sci 2018 10;15(12):1349-1354. Epub 2018 Aug 10.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

Gamma-aminobutyric acid (GABA), GABA-A receptors and GABA transporter 1 (GAT1) were reported to be involved in the proliferation of Leydig cells, testosterone production and spermatogenesis. Since methamphetamine (METH) has been reported to have adverse effects on testis and its functions, the aim of this study was therefore to determine the changes of GABAergic activity in testis after METH exposure. Male Sprague-Dawley rats were divided into control, acute binge (AB-METH), escalating dose (ED METH) and escalating dose-binge (ED-binge METH) groups. Read More

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http://www.medsci.org/v15p1349.htm
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http://dx.doi.org/10.7150/ijms.27609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158670PMC
January 2019
13 Reads

HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling.

Toxicol Lett 2018 Dec 24;299:159-171. Epub 2018 Sep 24.

CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address:

Methamphetamine (Meth) is an addictive psychostimulant whose abuse is intimately linked to increased risks for HIV-1 infection. Converging lines of evidence indicate that Meth also aggravates the symptoms of HIV-associated neurocognitive disorders (HAND), though the underlying mechanisms remain poorly understood. By using the lipophilic antioxidant N-acetylcysteine amide (NACA) as an interventional agent, we examined the roles of oxidative stress in autophagy and apoptosis induced by HIV-Tat (the transactivator of transcription), Meth or their combined treatment in human SH-SY5Y neuroblastoma cells and in the rat striatum. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.09.009DOI Listing
December 2018
21 Reads
3.260 Impact Factor

Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT receptors.

Biochem Pharmacol 2018 Dec 25;158:27-34. Epub 2018 Sep 25.

Research Service, VA Portland Health Care System, Portland, OR 97239, United States; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States; Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, United States; The Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR 97239, United States.

The use of new psychoactive substituted 2,5-dimethoxy-N-benzylphenethylamines is associated with abuse and toxicity in the United States and elsewhere and their pharmacology is not well known. This study compares the mechanisms of action of 2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe), 2-(4-ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25E-NBOMe), 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25H-NBOMe), 2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol (25I-NBOH); and 2-(2,5-dimethoxy-4-nitrophenyl)-N-(2-methoxybenzyl)ethanamine) (25N-NBOMe) with hallucinogens and stimulants. Mammalian cells heterologously expressing 5-HT, 5-HT, 5-HT or 5-HT receptors, or dopamine, serotonin or norepinephrine transporters (DAT, SERT and NET, respectively) were used to assess drug affinities at radioligand binding sites. Read More

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http://dx.doi.org/10.1016/j.bcp.2018.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298744PMC
December 2018
13 Reads

Severe neurologic and hepatic toxicity in a newborn prenatally exposed to methamphetamine. A case report.

Brain Dev 2019 Feb 10;41(2):191-194. Epub 2018 Sep 10.

Neonatology and Neonatal Intensive Care Unit, San Salvatore Hospital, L'Aquila, Italy.

Objective: In the recent years the increase of methamphetamines (MTA) abusers women has become an emerging problem. Very little data has been published regarding the effects of prenatal MTA exposure. We describe a case of MTA related toxicity in a term newborn which have early onset of neonatal encephalopathy and liver failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183043
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http://dx.doi.org/10.1016/j.braindev.2018.08.010DOI Listing
February 2019
23 Reads

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors.

Front Mol Neurosci 2018 29;11:307. Epub 2018 Aug 29.

Department of Applied Life Sciences, Graduate School, Konkuk University, Chungju, South Korea.

Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Although many studies on NDDs have been conducted, their exact pathophysiological characteristics are still not fully understood. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123546PMC
August 2018
3 Reads

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress.

Oxid Med Cell Longev 2018 22;2018:4982453. Epub 2018 Jul 22.

Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Pisa, Italy.

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field of drug abuse since it allows getting an insight into the molecular mechanisms which operate in a variety of neuropsychiatric disorders. In fact, key alterations produced by methamphetamine involve dopamine neurotransmission in a way, which is reminiscent of spontaneous neurodegeneration and psychiatric schizophrenia. Read More

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http://dx.doi.org/10.1155/2018/4982453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081569PMC
October 2018
10 Reads

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Nat Biotechnol 2018 10 20;36(9):865-874. Epub 2018 Aug 20.

Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes and conversions over the NVU rely on interactions between brain microvascular endothelium, perivascular pericytes, astrocytes and neurons, making it difficult to identify the contributions of each cell type. Here we model the human NVU using microfluidic organ chips, allowing analysis of the roles of individual cell types in NVU functions. Read More

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http://dx.doi.org/10.1038/nbt.4226DOI Listing
October 2018
29 Reads

Dissociation between hypothermia and neurotoxicity caused by mephedrone and methcathinone in TPH2 knockout mice.

Psychopharmacology (Berl) 2018 Aug 3. Epub 2018 Aug 3.

Research & Development Service, John D. Dingell VA Medical Center, R&D Service (11R), 4646 John R, Detroit, MI, 48201, USA.

Rationale: Mephedrone is a commonly abused constituent of "bath salts" and has many pharmacological effects in common with methamphetamine. Despite their structural similarity, mephedrone differs significantly from methamphetamine in its effects on core body temperature and dopamine nerve endings. The reasons for these differences remain unclear. Read More

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http://dx.doi.org/10.1007/s00213-018-4991-8DOI Listing
August 2018
3 Reads

Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011-2014).

Vet Med (Auckl) 2017 30;8:77-85. Epub 2017 Oct 30.

Emergency and Critical Care, Animal Specialty Group, Los Angeles, CA, USA,

The objective of this retrospective study was to describe the responses to treatment with intravenous lipid emulsion (ILE) and the outcomes for a variety of severe intoxications. This case series includes 10 client-owned animals, 9 dogs and 1 cat, that underwent treatment with ILE for a variety of severe intoxications over a 4-year period. History, physical examination findings, clinical signs, clinicopathological test results, treatment, response to treatment, and outcome were recorded. Read More

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http://dx.doi.org/10.2147/VMRR.S129576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042488PMC
October 2017
8 Reads

Involvement of insulin signalling pathway in methamphetamine-induced hyperphosphorylation of Tau.

Toxicology 2018 09 4;408:88-94. Epub 2018 Jul 4.

Department of Toxicology, The Key Lab of Modern Toxicology (NJMU), Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Methamphetamine (METH), an amphetamine-like drug, is one of the most commonly used central nervous system psychostimulants worldwide. METH abuse frequently leads to cognitive decline and dementia-like changes, but the mechanisms remain poorly understood. In the present study, the mechanisms of METH-induced changes in Alzheimer's disease-like pathological protein in Neuro2A cells were explored. Read More

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http://dx.doi.org/10.1016/j.tox.2018.07.002DOI Listing
September 2018
23 Reads

Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.

Cell Prolif 2018 Oct 28;51(5):e12476. Epub 2018 Jun 28.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Objectives: Methamphetamine (MA) abuse evokes pulmonary toxicity. The aim of our study is to investigate if autophagy is induced by MA and if autophagy-initiated apoptosis in alveolar epithelial cells is involved in MA-induced chronic pulmonary toxicity.

Materials And Methods: The rats in Control group and MA group were tested by Doppler and HE staining. Read More

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http://dx.doi.org/10.1111/cpr.12476DOI Listing
October 2018
12 Reads

Methamphetamine toxicity-induced calcineurin activation, nuclear translocation of nuclear factor of activated T-cells and elevation of cyclooxygenase 2 levels are averted by calpastatin overexpression in neuroblastoma SH-SY5Y cells.

Neurotoxicology 2018 07 23;67:287-295. Epub 2018 Jun 23.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, 73170, Thailand. Electronic address:

Methamphetamine (METH) is an addictive stimulant drug that has many negative consequences, including toxic effects to the brain. Recently, the induction of inflammatory processes has been identified as a potential contributing factor to induce neuronal cell degeneration. It has been demonstrated that the expression of inflammatory agents, such as cyclooxygenase 2 (COX-2), depends on the activation of calcineurin (CaN) and nuclear factor of activated T-cells (NFAT). Read More

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http://dx.doi.org/10.1016/j.neuro.2018.06.011DOI Listing
July 2018
20 Reads

Striatal Reinnervation Process after Acute Methamphetamine-Induced Dopaminergic Degeneration in Mice.

Neurotox Res 2018 Oct 22;34(3):627-639. Epub 2018 Jun 22.

Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC, Avda Dr Arce 37, 28002, Madrid, Spain.

Methamphetamine (METH), an amphetamine derivate, may increase the risk of developing Parkinson's disease (PD). Human and animal studies have shown that METH produces persistent dopaminergic neurotoxicity in the nigrostriatal pathway, despite initial partial recovery. To determine the processes leading to early compensation, we studied the detailed morphology and distribution of tyrosine hydroxylase immunoreactive fibers (TH-ir) classified by their thickness (types I-IV) before and after METH. Read More

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http://dx.doi.org/10.1007/s12640-018-9925-zDOI Listing
October 2018
8 Reads

The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment.

Front Mol Neurosci 2018 4;11:186. Epub 2018 Jun 4.

Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, China.

Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the accurate mechanism of toxic effect of the drug on central nervous system (CNS) has not yet been completely deciphered. Besides, effective treatment strategies toward METH neurotoxicity remain scarce and more efficacious drugs are to be developed. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994595PMC
June 2018
7 Reads

Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of -Hydroxymethamphetamine.

Drug Metab Dispos 2018 09 18;46(9):1277-1284. Epub 2018 Jun 18.

Departments of Pharmaceutics (D.J.W., L.M.S., D.D.S., J.W.) and Pharmacy (S.A.), University of Washington, Seattle, Washington

Methamphetamine is one of the most widely abused illicit drugs. Although human intoxication and multiple tissue toxicities frequently occur in abusers, little is known about the distribution of methamphetamine or its primary metabolites, amphetamine and -hydroxymethamphetamine (-OHMA), to their sites of toxicity. This study determined the pharmacokinetics, tissue exposure, and partition ratios of methamphetamine and major metabolites in various mouse tissues and investigated the impact of organic cation transporter 3 (Oct3) following i. Read More

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0821
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http://dx.doi.org/10.1124/dmd.118.082131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081671PMC
September 2018
20 Reads

Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats.

Int J Pharm 2018 Sep 7;548(1):1-14. Epub 2018 Jun 7.

Department of Morphology, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil; Post-Graduation Programme in Structural and Functional Biology, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil; Post-Graduation Programme in Health Science, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil. Electronic address:

This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.06.008DOI Listing
September 2018
3 Reads

Does Repeated Methamphetamine Exposure at Different Regimens Cause Parkinsonian-Like Behavior in Rats?

Iran J Pharm Res 2018 ;17(2):543-552

Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Methamphetamine (MA), a highly addictive psychostimulant, produces long-lasting neurotoxic effects well proven in nigrostriatal dopaminergic neurons. Considering the similarities between pathological profile of MA neurotoxicity and Parkinson's disease (PD), some reports show that previous MA abusers will be at greater risk of PD-like motor deficits. To answer the question if repeated MA exposure causes parkinsonian-like behavior in rats, we used three regimens of MA administration and assessed the motor performance parameters immediately and over a long period after MA discontinuation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985172PMC
January 2018
7 Reads

Effects of acute and chronic methamphetamine administration on cynomolgus monkey hippocampus structure and cellular transcriptome.

Toxicol Appl Pharmacol 2018 09 23;355:68-79. Epub 2018 May 23.

Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea. Electronic address:

Methamphetamine (MA), a psychostimulant abused worldwide, gives rise to neurotoxicity in the hippocampus, resulting in cognitive impairments and hippocampal volume reduction. The cellular and molecular mechanisms associated with hippocampal impairments due to MA remain unknown. The aim of this study was to investigate the effects of MA on structural alterations and gene expressions in the hippocampus. Read More

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http://dx.doi.org/10.1016/j.taap.2018.05.031DOI Listing
September 2018
2 Reads

17 β-Estradiol exacerbates methamphetamine-induced anxiety-like behavior in female mice.

Neurosci Lett 2018 08 20;681:44-49. Epub 2018 May 20.

Neuroscience Program, Dickinson College, Carlisle, PA, 17013, USA. Electronic address:

The present experiment investigated the effect of 17 β-estradiol (E) on anxiety-like behavior following methamphetamine administration in female, Swiss-Webster mice. Mice underwent bilateral ovariectomy (OVX) followed by a subcutaneous implantation of a Silastic capsule containing either sesame oil (OVX + Oil) or E (36 μg/ml; OVX + E). One week later, mice were placed in an open-field chamber for an 8-h session. Read More

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http://dx.doi.org/10.1016/j.neulet.2018.05.025DOI Listing
August 2018
7 Reads

Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.

ACS Chem Neurosci 2018 Nov 1;9(11):2701-2712. Epub 2018 Jun 1.

Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase catalytic subunits are much more promiscuous in their ability to dephosphorylate substrates. To obtain substrate specificity, serine/threonine phosphatases utilize targeting proteins to regulate phosphatase subcellular localization and catalytic activity. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00144DOI Listing
November 2018
3 Reads

Autophagy plays a pro-survival role against methamphetamine-induced apoptosis in H9C2 cells.

Toxicol Lett 2018 Sep 12;294:156-165. Epub 2018 May 12.

Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tian Yuan East Road, Nanjing, Jiangsu, 211166, China. Electronic address:

Methamphetamine (METH) is a commonly abused psychostimulant that can induce severe neurotoxicity. Cardiovascular injury caused by METH has recently gained increasing attention; however, the underlying mechanisms remain unclear. As autophagy has been shown to be associated with cell injury, the association between autophagy and METH-mediated cell apoptosis was investigated in the present study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183020
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http://dx.doi.org/10.1016/j.toxlet.2018.05.017DOI Listing
September 2018
12 Reads

The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats.

Neurotox Res 2018 Oct 30;34(3):525-537. Epub 2018 Apr 30.

Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna, 31-343, Kraków, Poland.

According to the European Drug Report (2016), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last years. Studies in humans indicate that psychostimulant drug use in adolescence increases risk of drug abuse in adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release to the synaptic cleft. Read More

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http://dx.doi.org/10.1007/s12640-018-9908-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154178PMC
October 2018
6 Reads

Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

Behav Brain Res 2018 09 27;349:73-79. Epub 2018 Apr 27.

Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.04.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320247PMC
September 2018
3 Reads

CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway.

Toxicol Lett 2018 Aug 26;292:97-107. Epub 2018 Apr 26.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

Overexposure to methamphetamine (METH) causes apoptosis in a number of cell types, particularly neuronal cells. However, the underlying mechanisms of METH-induced neuronal apoptosis remain to be elucidated. Accumulation of microtubule-associated protein Tau can lead to activation of multiple neurotoxic pathways, which is closely correlated with neuronal apoptosis. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.04.027DOI Listing
August 2018
52 Reads

Quantification of Methamphetamine «Shabu» in Biological Matrices to Detect Prenatal Exposure: A Case Report and a Literature Review.

Curr Pharm Biotechnol 2018 ;19(2):163-174

Drug Testing Consultants, #801 265 Russell Hill Road, Toronto, ON, M4V2T3, Canada.

Background: Methamphetamine misuse represents an increasing global public health problem. Its consumption during pregnancy becomes a relevant issue, since it has clinical consequences for the child's health and the pregnant woman. Despite this, there are only few data in the literature that include analytical results in the matrices used to detect prenatal exposure. Read More

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http://www.eurekaselect.com/161634/article
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http://dx.doi.org/10.2174/1389201019666180427111735DOI Listing
October 2018
14 Reads

Protective Effects of Ginsenoside Rb1 against Blood-Brain Barrier Damage Induced by Human Immunodeficiency Virus-1 Tat Protein and Methamphetamine in Sprague-Dawley Rats.

Am J Chin Med 2018 ;46(3):551-566

† School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, P. R. China.

Although antiretroviral therapy has helped to improve the lives of individuals infected with human immunodeficiency virus 1 (HIV-1), these patients are often still afflicted with HIV-1-associated neurocognitive disorders, which can lead to neurocognitive impairment and even dementia, and continue to hamper their quality of life. Methamphetamine abuse in HIV-1 patients poses a potential risk for HIV-associated neurocognitive disorders, because methamphetamine and HIV-1 proteins such as transactivator of transcription can synergistically damage the blood-brain barrier (BBB). In this study, we aimed to examine the effects of methamphetamine and HIV-1 Tat protein on the blood-brain barrier function and to determine whether ginsenoside Rb1 (GsRb1) plays a role in protecting the BBB. Read More

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http://dx.doi.org/10.1142/S0192415X18500283DOI Listing
July 2018
29 Reads